Gregory A Brent

Title(s)Professor, Medicine
SchoolMedicine
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    Other Positions
    Title(s)Professor, Physiology


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    Thyroid Hormone Receptor Isoform-Specific Actions
    NIH R01DK098576May 1, 2014 - Feb 28, 2019
    Role: Principal Investigator
    Thyroid Hormone and Neuronal Protection
    NIH I01BX001966Jan 1, 2014 - Mar 31, 2023
    Role: Principal Investigator
    Thyroid Hormone Receptor Isoform-Specific Actions
    NIH R01DK067233Mar 1, 2004 - Feb 28, 2010
    Role: Principal Investigator
    Regulation of the Sodium/Iodide Symporter in Breast
    NIH R01CA089364Jan 12, 2001 - Apr 30, 2013
    Role: Principal Investigator
    ANIMAL AND CELLULAR MODELS OF THYROID HORMONE RESISTANCE
    NIH R01DK043714Feb 1, 1992 - Apr 30, 2001
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Serum Thyrotropin Elevation and Coronary Artery Calcification in Hemodialysis Patients. Cardiorenal Med. 2022; 12(3):106-116. Rhee CM, Budoff M, Brent G, You AS, Stenvinkel P, Novoa A, Flores F, Hamal S, Dailing C, Kinninger A, Nakata T, Kovesdy CP, Nguyen DV, Kalantar-Zadeh K. PMID: 35551382; PMCID: PMC9452456.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Serum Thyroglobulin Measurement Following Surgery Without Radioactive Iodine for Differentiated Thyroid Cancer: A Systematic Review. Thyroid. 2022 06; 32(6):613-639. Chou R, Dana T, Brent GA, Goldner W, Haymart M, Leung AM, Ringel MD, Sosa JA. PMID: 35412871.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    3. Thyroid hormone receptor alpha sumoylation modulates white adipose tissue stores. Sci Rep. 2021 12 16; 11(1):24105. Liu YY, Jiang J, Ke S, Milanesi A, Abe K, Gastelum G, Li J, Brent GA. PMID: 34916557; PMCID: PMC8677787.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. Thyroid hormone receptor � sumoylation is required for thyrotropin regulation and thyroid hormone production. JCI Insight. 2021 08 23; 6(16). Ke S, Liu YY, Karthikraj R, Kannan K, Jiang J, Abe K, Milanesi A, Brent GA. PMID: 34237030; PMCID: PMC8410017.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    5. Elevated serum thyrotropin levels and endothelial dysfunction in a prospective hemodialysis cohort. Hemodial Int. 2022 01; 26(1):57-65. You AS, Budoff M, Zeb I, Ahmadi N, Novoa A, Flores F, Hamal S, Kinninger A, Dailing C, Nakata T, Kovesdy CP, Nguyen DV, Brent GA, Kalantar-Zadeh K, Rhee CM. PMID: 34231302.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. The Role of Thyroid Hormone in Neuronal Protection. Compr Physiol. 2021 06 01; 11(3):2075-2095. Liu YY, Brent GA. PMID: 34061976.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    7. Persistent COUP-TFII expression underlies the myopathy and impaired muscle regeneration observed in resistance to thyroid hormone-alpha. Sci Rep. 2021 02 25; 11(1):4601. Aguiari P, Liu YY, Petrosyan A, Cheng SY, Brent GA, Perin L, Milanesi A. PMID: 33633251; PMCID: PMC7907286.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    8. Association of Subclinical Hypothyroidism and Cardiovascular Disease With Mortality. JAMA Netw Open. 2020 02 05; 3(2):e1920745. Inoue K, Ritz B, Brent GA, Ebrahimi R, Rhee CM, Leung AM. PMID: 32031647.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    9. Association of thyroid status prior to transition to end-stage renal disease with early dialysis mortality. Nephrol Dial Transplant. 2019 12 01; 34(12):2095-2104. You AS, Sim JJ, Kovesdy CP, Streja E, Nguyen DV, Brent GA, Kalantar-Zadeh K, Rhee CM. PMID: 30299498; PMCID: PMC6887739.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    10. Thyroid Hormone Protects Primary Cortical Neurons Exposed to Hypoxia by Reducing DNA Methylation and Apoptosis. Endocrinology. 2019 10 01; 160(10):2243-2256. Li J, Abe K, Milanesi A, Liu YY, Brent GA. PMID: 31095291.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    11. Older Adults with Cognitive Impairment Have Sex: More Evidence Against the Medical Myth of Sexless Aging. J Am Geriatr Soc. 2018 10; 66(10):1870-1871. Granville L, Brent GA, Pregler J. PMID: 30207596.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    12. Thyroid Status and Death Risk in US Veterans With Chronic Kidney Disease. Mayo Clin Proc. 2018 05; 93(5):573-585. Rhee CM, Kalantar-Zadeh K, Ravel V, Streja E, You AS, Brunelli SM, Nguyen DV, Brent GA, Kovesdy CP. PMID: 29728200; PMCID: PMC6049829.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    13. Thyroid hormone and the brain: Mechanisms of action in development and role in protection and promotion of recovery after brain injury. Pharmacol Ther. 2018 06; 186:176-185. Liu YY, Brent GA. PMID: 29378220; PMCID: PMC5962384.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    14. COUP-TF1 Modulates Thyroid Hormone Action in an Embryonic Stem-Cell Model of Cortical Pyramidal Neuronal Differentiation. Thyroid. 2018 05; 28(5):667-678. Teng X, Liu YY, Teng W, Brent GA. PMID: 29205104; PMCID: PMC5952340.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    15. Posttranslational Modification of Thyroid Hormone Nuclear Receptor by Phosphorylation. Methods Mol Biol. 2018; 1801:39-46. Liu YY, Brent GA. PMID: 29892815.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    16. Posttranslational Modification of Thyroid Hormone Nuclear Receptor by Sumoylation. Methods Mol Biol. 2018; 1801:47-59. Liu YY, Brent GA. PMID: 29892816.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    17. Thyroid Hormone Receptor Alpha is Essential to Maintain the Satellite Cell Niche During Skeletal Muscle Injury and Sarcopenia of Aging. Thyroid. 2017 10; 27(10):1316-1322. Milanesi A, Lee JW, Yang A, Liu YY, Sedrakyan S, Cheng SY, Perin L, Brent GA. PMID: 28847239; PMCID: PMC5649408.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    18. Thyroid Status, Quality of Life, and Mental Health in Patients on Hemodialysis. Clin J Am Soc Nephrol. 2017 Aug 07; 12(8):1274-1283. Rhee CM, Chen Y, You AS, Brunelli SM, Kovesdy CP, Budoff MJ, Brent GA, Kalantar-Zadeh K, Nguyen DV. PMID: 28705886; PMCID: PMC5544520.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    19. Association of Glycemic Status During Progression of Chronic Kidney Disease With Early Dialysis Mortality in Patients With Diabetes. Diabetes Care. 2017 08; 40(8):1050-1057. Rhee CM, Kovesdy CP, Ravel VA, Streja E, Brunelli SM, Soohoo M, Sumida K, Molnar MZ, Brent GA, Nguyen DV, Kalantar-Zadeh K. PMID: 28592525; PMCID: PMC5521972.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    20. Thyroid hormone treatment activates protective pathways in both in vivo and in vitro models of neuronal injury. Mol Cell Endocrinol. 2017 09 05; 452:120-130. Li J, Donangelo I, Abe K, Scremin O, Ke S, Li F, Milanesi A, Liu YY, Brent GA. PMID: 28549992.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    21. Thyroid Status and Mortality in a Prospective Hemodialysis Cohort. J Clin Endocrinol Metab. 2017 05 01; 102(5):1568-1577. Rhee CM, You AS, Nguyen DV, Brunelli SM, Budoff MJ, Streja E, Nakata T, Kovesdy CP, Brent GA, Kalantar-Zadeh K. PMID: 28324018; PMCID: PMC5443328.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    22. Beam Me In: Thyroid Hormone Analog Targets Alternative Transporter in Mouse Model of X-Linked Adrenoleukodystrophy Endocrinology. 2017 04 29; 158(5):1116-1119. Milanesi A, Brent GA. PMID: 28609836; PMCID: PMC5460838.
      View in: PubMed   Mentions: 1     Fields:    
    23. 2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum. Thyroid. 2017 03; 27(3):315-389. Alexander EK, Pearce EN, Brent GA, Brown RS, Chen H, Dosiou C, Grobman WA, Laurberg P, Lazarus JH, Mandel SJ, Peeters RP, Sullivan S. PMID: 28056690.
      View in: PubMed   Mentions: 559     Fields:    Translation:Humans
    24. Thyroid Functional Disease and Mortality in a National Peritoneal Dialysis Cohort. J Clin Endocrinol Metab. 2016 11; 101(11):4054-4061. Rhee CM, Ravel VA, Streja E, Mehrotra R, Kim S, Wang J, Nguyen DV, Kovesdy CP, Brent GA, Kalantar-Zadeh K. PMID: 27525529; PMCID: PMC5095247.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    25. Exposure to Thyroid-Disrupting Chemicals: A Transatlantic Call for Action. Thyroid. 2016 Apr; 26(4):479-80. Leung AM, Korevaar TI, Peeters RP, Zoeller RT, K?hrle J, Duntas LH, Brent GA, Demeneix BA. PMID: 26906244; PMCID: PMC4827314.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansPHPublic Health
    26. Thyroid Hormone Receptor a Plays an Essential Role in Male Skeletal Muscle Myoblast Proliferation, Differentiation, and Response to Injury. Endocrinology. 2016 Jan; 157(1):4-15. Milanesi A, Lee JW, Kim NH, Liu YY, Yang A, Sedrakyan S, Kahng A, Cervantes V, Tripuraneni N, Cheng SY, Perin L, Brent GA. PMID: 26451739; PMCID: PMC4701883.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    27. A Patient With a Thyrotropin-Secreting Microadenoma and Resistance to Thyroid Hormone (P453T). J Clin Endocrinol Metab. 2015 Jul; 100(7):2511-4. Teng X, Jin T, Brent GA, Wu A, Teng W, Shan Z. PMID: 25867808; PMCID: PMC5393528.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    28. Association of Adiponectin With Body Composition and Mortality in Hemodialysis Patients. Am J Kidney Dis. 2015 Aug; 66(2):313-21. Rhee CM, Nguyen DV, Moradi H, Brunelli SM, Dukkipati R, Jing J, Nakata T, Kovesdy CP, Brent GA, Kalantar-Zadeh K. PMID: 25824125; PMCID: PMC4516594.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    29. Association of thyroid functional disease with mortality in a national cohort of incident hemodialysis patients. J Clin Endocrinol Metab. 2015 Apr; 100(4):1386-95. Rhee CM, Kim S, Gillen DL, Oztan T, Wang J, Mehrotra R, Kuttykrishnan S, Nguyen DV, Brunelli SM, Kovesdy CP, Brent GA, Kalantar-Zadeh K. PMID: 25632971; PMCID: PMC4399303.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    30. Thyroid hormone receptor sumoylation is required for preadipocyte differentiation and proliferation. J Biol Chem. 2015 Mar 20; 290(12):7402-15. Liu YY, Ayers S, Milanesi A, Teng X, Rabi S, Akiba Y, Brent GA. PMID: 25572392; PMCID: PMC4367250.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    31. Thyrotoxicosis of Pregnancy. J Clin Transl Endocrinol. 2014 Dec 01; 1(4):140-144. Labadzhyan A, Brent GA, Hershman JM, Leung AM. PMID: 25243108; PMCID: PMC4166486.
      View in: PubMed   Mentions: 9  
    32. A review: Radiographic iodinated contrast media-induced thyroid dysfunction. J Clin Endocrinol Metab. 2015 Feb; 100(2):376-83. Lee SY, Rhee CM, Leung AM, Braverman LE, Brent GA, Pearce EN. PMID: 25375985; PMCID: PMC4318903.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    33. Perchlorate exposure in pregnancy and cognitive outcomes in children: it's not your mother's thyroid. J Clin Endocrinol Metab. 2014 Nov; 99(11):4066-8. Brent GA. PMID: 25372124; PMCID: PMC4223440.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    34. Thyroid hormone regulation of metabolism. Physiol Rev. 2014 Apr; 94(2):355-82. Mullur R, Liu YY, Brent GA. PMID: 24692351; PMCID: PMC4044302.
      View in: PubMed   Mentions: 522     Fields:    Translation:HumansAnimalsCells
    35. Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism. Eur Thyroid J. 2014 Mar; 3(1):7-9. Refetoff S, Bassett JH, Beck-Peccoz P, Bernal J, Brent G, Chatterjee K, De Groot LJ, Dumitrescu AM, Jameson JL, Kopp PA, Murata Y, Persani L, Samarut J, Weiss RE, Williams GR, Yen PM. PMID: 24847459; PMCID: PMC4005262.
      View in: PubMed   Mentions: 11  
    36. Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism. Thyroid. 2014 Mar; 24(3):407-9. Refetoff S, Bassett JH, Beck-Peccoz P, Bernal J, Brent G, Chatterjee K, De Groot LJ, Dumitrescu AM, Jameson JL, Kopp PA, Murata Y, Persani L, Samarut J, Weiss RE, Williams GR, Yen PM. PMID: 24588711; PMCID: PMC3950730.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    37. Updates on the management of diabetes in dialysis patients. Semin Dial. 2014 Mar; 27(2):135-45. Rhee CM, Leung AM, Kovesdy CP, Lynch KE, Brent GA, Kalantar-Zadeh K. PMID: 24588802; PMCID: PMC3960718.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    38. Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism. J Clin Endocrinol Metab. 2014 Mar; 99(3):768-70. Refetoff S, Bassett JH, Beck-Peccoz P, Bernal J, Brent G, Chatterjee K, De Groot LJ, Dumitrescu AM, Jameson JL, Kopp PA, Murata Y, Persani L, Samarut J, Weiss RE, Williams GR, Yen PM. PMID: 24823702; PMCID: PMC3942236.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    39. Thyroid functional disease: an under-recognized cardiovascular risk factor in kidney disease patients. Nephrol Dial Transplant. 2015 May; 30(5):724-37. Rhee CM, Brent GA, Kovesdy CP, Soldin OP, Nguyen D, Budoff MJ, Brunelli SM, Kalantar-Zadeh K. PMID: 24574542; PMCID: PMC4425477.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    40. Commentary on: "American Thyroid Association Guide to investigating thyroid hormone economy and action in rodent and cell models," Bianco et al. Thyroid. 2014 Jan; 24(1):1-2. Brent GA. PMID: 24303889; PMCID: PMC3887401.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    41. Children of mothers with iodine deficiency during pregnancy are more likely to have lower verbal IQ and reading scores at 8-9 years of age. Evid Based Nurs. 2014 Jul; 17(3):86. Leung AM, Brent GA. PMID: 24336752; PMCID: PMC4055540.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    42. Cancer: Novel target to enhance radioiodine uptake in thyroid cancer. Nat Rev Endocrinol. 2013 Sep; 9(9):508-9. Brent GA, Kogai T. PMID: 23817292.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    43. Mechanisms of thyroid hormone action. J Clin Invest. 2012 Sep; 122(9):3035-43. Brent GA. PMID: 22945636; PMCID: PMC3433956.
      View in: PubMed   Mentions: 306     Fields:    Translation:HumansAnimalsCells
    44. Thyroid hormone receptor isoform-specific modification by small ubiquitin-like modifier (SUMO) modulates thyroid hormone-dependent gene regulation. J Biol Chem. 2012 Oct 19; 287(43):36499-508. Liu YY, Kogai T, Schultz JJ, Mody K, Brent GA. PMID: 22930759; PMCID: PMC3476315.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    45. The sodium iodide symporter (NIS): regulation and approaches to targeting for cancer therapeutics. Pharmacol Ther. 2012 Sep; 135(3):355-70. Kogai T, Brent GA. PMID: 22750642; PMCID: PMC3408573.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    46. The debate over thyroid-function screening in pregnancy. N Engl J Med. 2012 Feb 09; 366(6):562-3. Brent GA. PMID: 22316450.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    47. Regulation of sodium iodide symporter gene expression by Rac1/p38� mitogen-activated protein kinase signaling pathway in MCF-7 breast cancer cells. J Biol Chem. 2012 Jan 27; 287(5):3292-300. Kogai T, Liu YY, Mody K, Shamsian DV, Brent GA. PMID: 22157753; PMCID: PMC3270984.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    48. Management of hypothyroidism in pregnancy. Curr Opin Endocrinol Diabetes Obes. 2011 Oct; 18(5):304-9. Milanesi A, Brent GA. PMID: 21841481.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    49. Publication of industry-sponsored medical research: guidelines from the Consortium of Laboratory Medicine Journal Editors. Thyroid. 2011 Jul; 21(7):693. Soldin OP, Brent GA, Kloos RT. PMID: 21707435.
      View in: PubMed   Mentions:    Fields:    
    50. Thyroid hormone and COUP-TF1 regulate kallikrein-binding protein (KBP) gene expression. Endocrinology. 2011 Mar; 152(3):1143-53. Liu YY, Nakatani T, Kogai T, Mody K, Brent GA. PMID: 21266512; PMCID: PMC3040047.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    51. Environmental exposures and autoimmune thyroid disease. Thyroid. 2010 Jul; 20(7):755-61. Brent GA. PMID: 20578899; PMCID: PMC2935336.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsPHPublic Health
    52. The impact of perchlorate exposure in early pregnancy: is it safe to drink the water? J Clin Endocrinol Metab. 2010 Jul; 95(7):3154-7. Brent GA. PMID: 20610607; PMCID: PMC2928898.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansPHPublic Health
    53. Retinoic acid induces expression of the thyroid hormone transporter, monocarboxylate transporter 8 (Mct8). J Biol Chem. 2010 Aug 27; 285(35):27279-27288. Kogai T, Liu YY, Richter LL, Mody K, Kagechika H, Brent GA. PMID: 20573951; PMCID: PMC2930727.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    54. Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation. Trends Endocrinol Metab. 2010 Mar; 21(3):166-73. Liu YY, Brent GA. PMID: 20015660; PMCID: PMC2831161.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    55. Expression of uncoupling protein 1 in mouse brown adipose tissue is thyroid hormone receptor-beta isoform specific and required for adaptive thermogenesis. Endocrinology. 2010 Jan; 151(1):432-40. Ribeiro MO, Bianco SD, Kaneshige M, Schultz JJ, Cheng SY, Bianco AC, Brent GA. PMID: 19906816; PMCID: PMC2817565.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    56. Activation of the PI3 kinase pathway by retinoic acid mediates sodium/iodide symporter induction and iodide transport in MCF-7 breast cancer cells. Cancer Res. 2009 Apr 15; 69(8):3443-50. Ohashi E, Kogai T, Kagechika H, Brent GA. PMID: 19351850; PMCID: PMC2852426.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    57. Phosphoinositide-3-kinase inhibition induces sodium/iodide symporter expression in rat thyroid cells and human papillary thyroid cancer cells. J Endocrinol. 2008 Nov; 199(2):243-52. Kogai T, Sajid-Crockett S, Newmarch LS, Liu YY, Brent GA. PMID: 18762555.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    58. Clinical practice. Graves' disease. N Engl J Med. 2008 Jun 12; 358(24):2594-605. Brent GA. PMID: 18550875.
      View in: PubMed   Mentions: 153     Fields:    Translation:Humans
    59. Stealth sequences in reporter gene vectors confound studies of T3-regulated negative gene expression. Thyroid. 2008 Jun; 18(6):593-5. Liu YY, Brent GA. PMID: 18578606.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    60. Retinoic acid stimulation of the sodium/iodide symporter in MCF-7 breast cancer cells is mediated by the insulin growth factor-I/phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase signaling pathways. J Clin Endocrinol Metab. 2008 May; 93(5):1884-92. Kogai T, Ohashi E, Jacobs MS, Sajid-Crockett S, Fisher ML, Kanamoto Y, Brent GA. PMID: 18319322; PMCID: PMC2386284.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    61. Thyroid health and the environment. Thyroid. 2007 Sep; 17(9):807-9. Brent GA, Braverman LE, Zoeller RT. PMID: 17956154.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansPHPublic Health
    62. Diagnosing thyroid dysfunction in pregnant women: Is case finding enough? J Clin Endocrinol Metab. 2007 Jan; 92(1):39-41. Brent GA. PMID: 17209222.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    63. Thyroid hormone regulates endogenous amyloid-beta precursor protein gene expression and processing in both in vitro and in vivo models. Thyroid. 2006 Dec; 16(12):1207-13. O'Barr SA, Oh JS, Ma C, Brent GA, Schultz JJ. PMID: 17199430.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    64. A mutant thyroid hormone receptor alpha antagonizes peroxisome proliferator-activated receptor alpha signaling in vivo and impairs fatty acid oxidation. Endocrinology. 2007 Mar; 148(3):1206-17. Liu YY, Heymann RS, Moatamed F, Schultz JJ, Sobel D, Brent GA. PMID: 17122078.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    65. Anaplastic thyroid carcinoma with thyrotoxicosis and hypoparathyroidism. Endocr Pract. 2005 Jul-Aug; 11(4):281-4. Heymann RS, Brent GA, Hershman JM. PMID: 16006301.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    66. Differential regulation of sodium/iodide symporter gene expression by nuclear receptor ligands in MCF-7 breast cancer cells. Endocrinology. 2005 Jul; 146(7):3059-69. Kogai T, Kanamoto Y, Li AI, Che LH, Ohashi E, Taki K, Chandraratna RA, Saito T, Brent GA. PMID: 15817668.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    67. Rapid progression from subclinical to symptomatic overt hypothyroidism. Endocr Pract. 2005 Mar-Apr; 11(2):115-9. Heymann R, Brent GA. PMID: 15901527.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    68. Resistance to thyroid hormone in Hashimoto's thyroiditis. N Engl J Med. 2005 Feb 03; 352(5):517-8. Fukata S, Brent GA, Sugawara M. PMID: 15689599.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    69. Introduction. The impact of maternal thyroid diseases on the developing fetus: implications for diagnosis, treatment, and screening. Summary of proceedings, workshop organization, program, and participants. Thyroid. 2005 Jan; 15(1):36-40. Brent G, Boyle CA. PMID: 15687821.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    70. Regulation of regional expression in rat brain PC2 by thyroid hormone/characterization of novel negative thyroid hormone response elements in the PC2 promoter. Am J Physiol Endocrinol Metab. 2005 Jan; 288(1):E236-45. Shen X, Li QL, Brent GA, Friedman TC. PMID: 15585599.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    71. Thyroid function inside and outside of pregnancy: what do we know and what don't we know? Thyroid. 2005 Jan; 15(1):54-9. Smallridge RC, Glinoer D, Hollowell JG, Brent G. PMID: 15687824.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    72. Thyroid hormone-dependent gene expression in differentiated embryonic stem cells and embryonal carcinoma cells: identification of novel thyroid hormone target genes by deoxyribonucleic acid microarray analysis. Endocrinology. 2005 Feb; 146(2):776-83. Liu YY, Brent GA. PMID: 15550503.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    73. Systemic retinoic acid treatment induces sodium/iodide symporter expression and radioiodide uptake in mouse breast cancer models. Cancer Res. 2004 Jan 01; 64(1):415-22. Kogai T, Kanamoto Y, Che LH, Taki K, Moatamed F, Schultz JJ, Brent GA. PMID: 14729653.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    74. Enhanced expression of nicotinamide N-methyltransferase in human papillary thyroid carcinoma cells. J Clin Endocrinol Metab. 2003 Oct; 88(10):4990-6. Xu J, Moatamed F, Caldwell JS, Walker JR, Kraiem Z, Taki K, Brent GA, Hershman JM. PMID: 14557485.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    75. Spared bone mass in rats treated with thyroid hormone receptor TR beta-selective compound GC-1. Am J Physiol Endocrinol Metab. 2003 Nov; 285(5):E1135-41. Freitas FR, Moriscot AS, Jorgetti V, Soares AG, Passarelli M, Scanlan TS, Brent GA, Bianco AC, Gouveia CH. PMID: 12965872.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    76. Follow-up of newborns with elevated screening T4 concentrations. J Pediatr. 2003 Sep; 143(3):296-301. Lafranchi SH, Snyder DB, Sesser DE, Skeels MR, Singh N, Brent GA, Nelson JC. PMID: 14517508.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansPHPublic Health
    77. Nonradioactive iodide effectively induces apoptosis in genetically modified lung cancer cells. Cancer Res. 2003 Aug 15; 63(16):5065-72. Zhang L, Sharma S, Zhu LX, Kogai T, Hershman JM, Brent GA, Dubinett SM, Huang M. PMID: 12941836.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    78. A thyroid hormone receptor alpha gene mutation (P398H) is associated with visceral adiposity and impaired catecholamine-stimulated lipolysis in mice. J Biol Chem. 2003 Oct 03; 278(40):38913-20. Liu YY, Schultz JJ, Brent GA. PMID: 12869545.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    79. The modified firefly luciferase reporter gene (luc+) but not Renilla luciferase is induced by all-trans retinoic acid in MCF-7 breast cancer cells. Breast Cancer Res Treat. 2003 Mar; 78(1):119-26. Kogai T, Kanamoto Y, Brent GA. PMID: 12611464.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    80. A complex deoxyribonucleic acid response element in the rat Ca(2+)/calmodulin-dependent protein kinase IV gene 5'-flanking region mediates thyroid hormone induction and chicken ovalbumin upstream promoter transcription factor 1 repression. Mol Endocrinol. 2002 Nov; 16(11):2439-51. Liu YY, Brent GA. PMID: 12403833.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    81. A thyroid-specific far-upstream enhancer in the human sodium/iodide symporter gene requires Pax-8 binding and cyclic adenosine 3',5'-monophosphate response element-like sequence binding proteins for full activity and is differentially regulated in normal and thyroid cancer cells. Mol Endocrinol. 2002 Oct; 16(10):2266-82. Taki K, Kogai T, Kanamoto Y, Hershman JM, Brent GA. PMID: 12351692.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    82. Thyroid hormone gene targets in ROS 17/2.8 osteoblast-like cells identified by differential display analysis. Thyroid. 2002 Aug; 12(8):663-71. Gouveia CH, Schultz JJ, Jackson DJ, Williams GR, Brent GA. PMID: 12225634.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    83. A targeted thyroid hormone receptor alpha gene dominant-negative mutation (P398H) selectively impairs gene expression in differentiated embryonic stem cells. Endocrinology. 2002 Jul; 143(7):2664-72. Liu YY, Tachiki KH, Brent GA. PMID: 12072400.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    84. Nonthyroidal illness syndrome: evaluation of thyroid function in sick patients. Endocrinol Metab Clin North Am. 2002 Mar; 31(1):159-72. Langton JE, Brent GA. PMID: 12055987.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    85. A GC box in the human sodium iodide symporter gene promoter is essential for full activity. Thyroid. 2002 Feb; 12(2):107-14. Xu J, Kogai T, Brent GA, Hershman JM. PMID: 11916279.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    86. The Kaposi sarcoma-associated herpesvirus (KSHV) induces cellular interleukin 6 expression: role of the KSHV latency-associated nuclear antigen and the AP1 response element. Blood. 2002 Jan 15; 99(2):649-54. An J, Lichtenstein AK, Brent G, Rettig MB. PMID: 11781250.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
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