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Matthew B Rettig

Title(s)Professor-in-Residence, Medicine
SchoolMedicine
Address555 Westwood Plaza MAILROOM
Los Angeles CA 90024
Phone43565
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    Other Positions
    Title(s)Professor-in-Residence, Urology


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    A Phase 2 study of a Checkpoint Inhibitor in Men with Progressive Metastatic Castrate Resistant Prostate Cancer Characterized by a Mismatch Repair Deficiency or Biallelic CDK12 Inactivation
    VA I01CX002006Apr 1, 2020 - Mar 31, 2023
    Role: Principal Investigator
    HIF-alpha-independent Druggable Targets in Renal Cell Carcinoma
    VA I01BX002778Oct 1, 2015 - Sep 30, 2019
    Role: Principal Investigator
    Identification of Inhibitors of the N-Terminal Region of the Androgen Receptor
    NIH/NCI R01CA164331Sep 26, 2012 - Jul 31, 2017
    Role: Principal Investigator
    Targeting HPV E6-Dependent Hypoxia-Induced NF-kappa B in Cervical Cancer
    VA I01CX000324Oct 1, 2011 - Sep 30, 2015
    Role: Principal Investigator
    Targeting Androgen Receptor Activity in Prostate Cancer
    NIH/NCI R21CA113351Feb 1, 2006 - Jan 31, 2009
    Role: Principal Investigator
    Increased IL6 Transcription by HHV8
    NIH/NCI R01CA080004Mar 15, 2002 - Feb 28, 2008
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. False positive PSMA PET for tumor remnants in the irradiated prostate and other interpretation pitfalls in a prospective multi-center trial. Eur J Nucl Med Mol Imaging. 2020 Aug 17. Fendler WP, Calais J, Eiber M, Simko JP, Kurhanewicz J, Santos RD, Feng FY, Reiter RE, Rettig MB, Nickols NG, Kishan AU, Slavik R, Carroll PR, Lawhn-Heath C, Herrmann K, Czernin J, Hope TA. PMID: 32808077.
      View in: PubMed   Mentions:    Fields:    
    2. The intraprostatic immune environment after stereotactic body radiotherapy is dominated by myeloid cells. Prostate Cancer Prostatic Dis. 2020 Jul 09. Nickols NG, Ganapathy E, Nguyen C, Kane N, Lin L, Diaz-Perez S, Nazarian R, Mathis C, Felix C, Basehart V, Zomorodian N, Kwak J, Kishan AU, King CR, Kupelian PA, Rettig MB, Steinberg ML, Cao M, Knudsen BS, Chu FI, Romero T, Elashoff D, Reiter RE, Schaue D. PMID: 32647353.
      View in: PubMed   Mentions:    Fields:    
    3. Transcriptomic Heterogeneity of Gleason Grade Group 5 Prostate Cancer. Eur Urol. 2020 Sep; 78(3):327-332. Kishan AU, Romero T, Alshalalfa M, Liu Y, Tran PT, Nickols NG, Ye H, Sajed D, Rettig MB, Reiter RE, Garraway IP, Spratt DE, Freedland SJ, Zhao X, Li Z, Deek M, Livingstone J, Mahal BA, Nguyen PL, Feng FY, Den RB, Schaeffer EM, Lotan TL, Karnes RJ, Klein EA, Ross AE, Grogan T, Davicioni E, Elashoff D, Boutros PC, Weidhaas JB. PMID: 32461072.
      View in: PubMed   Mentions:    Fields:    
    4. Arctigenin inhibits prostate tumor growth in high-fat diet fed mice through dual actions on adipose tissue and tumor. Sci Rep. 2020 Jan 29; 10(1):1403. Hao Q, Diaz T, Verduzco ADR, Magyar CE, Zhong J, Elshimali Y, Rettig MB, Henning SM, Vadgama JV, Wang P. PMID: 31996731.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    5. Impact of 68Ga-PSMA-11 PET/CT on Staging and Management of Prostate Cancer Patients in Various Clinical Settings: A Prospective Single-Center Study. J Nucl Med. 2020 Aug; 61(8):1153-1160. Sonni I, Eiber M, Fendler WP, Alano RM, Vangala SS, Kishan AU, Nickols N, Rettig MB, Reiter RE, Czernin J, Calais J. PMID: 31924715.
      View in: PubMed   Mentions: 1     Fields:    
    6. Local Failure and Survival After Definitive Radiotherapy for Aggressive Prostate Cancer: An Individual Patient-level Meta-analysis of Six Randomized Trials. Eur Urol. 2020 02; 77(2):201-208. Kishan AU, Chu FI, King CR, Seiferheld W, Spratt DE, Tran P, Wang X, Pugh SE, Sandler KA, Bolla M, Maingon P, De Reijke T, Nickols NG, Rettig M, Drakaki A, Liu ST, Reiter RE, Chang AJ, Feng FY, Sajed D, Nguyen PL, Kupelian PA, Steinberg ML, Boutros PC, Elashoff D, Collette L, Sandler HM. PMID: 31718822.
      View in: PubMed   Mentions: 3     Fields:    
    7. The size of cell-free mitochondrial DNA in blood is inversely correlated with tumor burden in cancer patients. Precis Clin Med. 2019 Sep; 2(3):131-139. An Q, Hu Y, Li Q, Chen X, Huang J, Pellegrini M, Zhou XJ, Rettig M, Fan G. PMID: 31598384.
      View in: PubMed   Mentions:
    8. 18F-fluciclovine PET-CT and 68Ga-PSMA-11 PET-CT in patients with early biochemical recurrence after prostatectomy: a prospective, single-centre, single-arm, comparative imaging trial. Lancet Oncol. 2019 09; 20(9):1286-1294. Calais J, Ceci F, Eiber M, Hope TA, Hofman MS, Rischpler C, Bach-Gansmo T, Nanni C, Savir-Baruch B, Elashoff D, Grogan T, Dahlbom M, Slavik R, Gartmann J, Nguyen K, Lok V, Jadvar H, Kishan AU, Rettig MB, Reiter RE, Fendler WP, Czernin J. PMID: 31375469.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    9. Activation of MAPK Signaling by CXCR7 Leads to Enzalutamide Resistance in Prostate Cancer. Cancer Res. 2019 05 15; 79(10):2580-2592. Li S, Fong KW, Gritsina G, Zhang A, Zhao JC, Kim J, Sharp A, Yuan W, Aversa C, Yang XJ, Nelson PS, Feng FY, Chinnaiyan AM, de Bono JS, Morrissey C, Rettig MB, Yu J. PMID: 30952632.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    10. Systemic and tumor-directed therapy for oligometastatic prostate cancer: study protocol for a phase II trial for veterans with de novo oligometastatic disease. BMC Cancer. 2019 Apr 01; 19(1):291. Parikh NR, Huiza C, Patel JS, Tsai S, Kalpage N, Thein M, Pitcher S, Lee SP, Inouye WS, Jordan ML, Sanati H, Jafari L, Bennett CJ, Gin GE, Kishan AU, Reiter RE, Lewis M, Sadeghi A, Aronson WJ, Garraway IP, Rettig MB, Nickols NG. PMID: 30935383.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    11. MEK-ERK signaling is a therapeutic target in metastatic castration resistant prostate cancer. Prostate Cancer Prostatic Dis. 2019 12; 22(4):531-538. Nickols NG, Nazarian R, Zhao SG, Tan V, Uzunangelov V, Xia Z, Baertsch R, Neeman E, Gao AC, Thomas GV, Howard L, De Hoedt AM, Stuart J, Goldstein T, Chi K, Gleave ME, Graff JN, Beer TM, Drake JM, Evans CP, Aggarwal R, Foye A, Feng FY, Small EJ, Aronson WJ, Freedland SJ, Witte ON, Huang J, Alumkal JJ, Reiter RE, Rettig MB. PMID: 30804427.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    12. Underutilization of Androgen Deprivation Therapy with External Beam Radiotherapy in Men with High-grade Prostate Cancer. Eur Urol Oncol. 2019 Feb 01. Wang C, Raldow AC, Nickols NG, Nguyen PL, Spratt DE, Dess RT, Yu JB, King CR, Chu FI, Chamie K, Litwin MS, Saigal CS, Reiter RE, Liu ST, Rettig MB, Chang AJ, Steinberg ML, Kupelian PA, Kishan AU. PMID: 31411981.
      View in: PubMed   Mentions:    Fields:    
    13. Preclinical evaluation of PSMA expression in response to androgen receptor blockade for theranostics in prostate cancer. EJNMMI Res. 2018 Oct 29; 8(1):96. Lückerath K, Wei L, Fendler WP, Evans-Axelsson S, Stuparu AD, Slavik R, Mona CE, Calais J, Rettig M, Reiter RE, Herrmann K, Radu CG, Czernin J, Eiber M. PMID: 30374743.
      View in: PubMed   Mentions:
    14. Functional profiling of circulating tumor cells with an integrated vortex capture and single-cell protease activity assay. Proc Natl Acad Sci U S A. 2018 10 02; 115(40):9986-9991. Dhar M, Lam JN, Walser T, Dubinett SM, Rettig MB, Di Carlo D. PMID: 30224472.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    15. Detection Threshold and Reproducibility of 68Ga-PSMA11 PET/CT in a Mouse Model of Prostate Cancer. J Nucl Med. 2018 09; 59(9):1392-1397. Lückerath K, Stuparu AD, Wei L, Kim W, Radu CG, Mona CE, Calais J, Rettig M, Reiter RE, Czernin J, Slavik R, Herrmann K, Eiber M, Fendler WP. PMID: 29602819.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    16. Keratin 13 Is Enriched in Prostate Tubule-Initiating Cells and May Identify Primary Prostate Tumors that Metastasize to the Bone. PLoS One. 2016; 11(10):e0163232. Liu S, Cadaneanu RM, Zhang B, Huo L, Lai K, Li X, Galet C, Grogan TR, Elashoff D, Freedland SJ, Rettig M, Aronson WJ, Knudsen BS, Lewis MS, Garraway IP. PMID: 27711225.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    17. Quantitative Magnetic Separation of Particles and Cells Using Gradient Magnetic Ratcheting. Small. 2016 Apr 13; 12(14):1891-9. Murray C, Pao E, Tseng P, Aftab S, Kulkarni R, Rettig M, Di Carlo D. PMID: 26890496.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    18. The Crossroads of Geriatric Cardiology and Cardio-Oncology. Curr Geriatr Rep. 2015; 4(4):327-337. Nguyen KL, Alrezk R, Mansourian PG, Naeim A, Rettig MB, Lee CC. PMID: 26543801.
      View in: PubMed   Mentions:
    19. Pomegranate extract inhibits EMT in clear cell renal cell carcinoma in a NF-?B and JNK dependent manner. Asian J Urol. 2015 Jan; 2(1):38-45. An J, Guo Y, Wang T, Pantuck AJ, Rettig MB. PMID: 29264118.
      View in: PubMed   Mentions:
    20. Association between tumor-associated macrophage infiltration, high grade prostate cancer, and biochemical recurrence after radical prostatectomy. Am J Cancer Res. 2013; 3(5):523-9. Gollapudi K, Galet C, Grogan T, Zhang H, Said JW, Huang J, Elashoff D, Freedland SJ, Rettig M, Aronson WJ. PMID: 24224130.
      View in: PubMed   Mentions:
    21. Size-selective collection of circulating tumor cells using Vortex technology. Lab Chip. 2014 Jan 07; 14(1):63-77. Sollier E, Go DE, Che J, Gossett DR, O'Byrne S, Weaver WM, Kummer N, Rettig M, Goldman J, Nickols N, McCloskey S, Kulkarni RP, Di Carlo D. PMID: 24061411.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansCells
    22. NanoVelcro Chip for CTC enumeration in prostate cancer patients. Methods. 2013 Dec 01; 64(2):144-52. Lu YT, Zhao L, Shen Q, Garcia MA, Wu D, Hou S, Song M, Xu X, Ouyang WH, Ouyang WW, Lichterman J, Luo Z, Xuan X, Huang J, Chung LW, Rettig M, Tseng HR, Shao C, Posadas EM. PMID: 23816790.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    23. High-purity prostate circulating tumor cell isolation by a polymer nanofiber-embedded microchip for whole exome sequencing. Adv Mater. 2013 Jun 04; 25(21):2897-902. Zhao L, Lu YT, Li F, Wu K, Hou S, Yu J, Shen Q, Wu D, Song M, OuYang WH, Luo Z, Lee T, Fang X, Shao C, Xu X, Garcia MA, Chung LW, Rettig M, Tseng HR, Posadas EM. PMID: 23529932.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    24. Hyperactivated JNK is a therapeutic target in pVHL-deficient renal cell carcinoma. Cancer Res. 2013 Feb 15; 73(4):1374-85. An J, Liu H, Magyar CE, Guo Y, Veena MS, Srivatsan ES, Huang J, Rettig MB. PMID: 23393199.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    25. c-Crk proto-oncogene contributes to transcriptional repression of p120-catenin in non-small cell lung cancer cells. Clin Exp Metastasis. 2011 Apr; 28(4):391-404. Mortazavi F, Dubinett S, Rettig M. PMID: 21336985.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    26. Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance. Nat Med. 2010 Dec; 16(12):1414-20. Tanaka H, Kono E, Tran CP, Miyazaki H, Yamashiro J, Shimomura T, Fazli L, Wada R, Huang J, Vessella RL, An J, Horvath S, Gleave M, Rettig MB, Wainberg ZA, Reiter RE. PMID: 21057494.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansAnimalsCells
    27. p120-catenin is transcriptionally downregulated by FOXC2 in non-small cell lung cancer cells. Mol Cancer Res. 2010 May; 8(5):762-74. Mortazavi F, An J, Dubinett S, Rettig M. PMID: 20460685.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    28. NF-kappaB-dependent plasticity of the epithelial to mesenchymal transition induced by Von Hippel-Lindau inactivation in renal cell carcinomas. Cancer Res. 2010 Jan 15; 70(2):752-61. Pantuck AJ, An J, Liu H, Rettig MB. PMID: 20068166.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    29. Inactivation of the CYLD deubiquitinase by HPV E6 mediates hypoxia-induced NF-kappaB activation. Cancer Cell. 2008 Nov 04; 14(5):394-407. An J, Mo D, Liu H, Veena MS, Srivatsan ES, Massoumi R, Rettig MB. PMID: 18977328.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    30. Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-kappaB-dependent mechanism. Mol Cancer Ther. 2008 Sep; 7(9):2662-71. Rettig MB, Heber D, An J, Seeram NP, Rao JY, Liu H, Klatte T, Belldegrun A, Moro A, Henning SM, Mo D, Aronson WJ, Pantuck A. PMID: 18790748.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    31. Ellagitannin-rich pomegranate extract inhibits angiogenesis in prostate cancer in vitro and in vivo. Int J Oncol. 2008 Feb; 32(2):475-80. Sartippour MR, Seeram NP, Rao JY, Moro A, Harris DM, Henning SM, Firouzi A, Rettig MB, Aronson WJ, Pantuck AJ, Heber D. PMID: 18202771.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    32. Pomegranate ellagitannin-derived metabolites inhibit prostate cancer growth and localize to the mouse prostate gland. J Agric Food Chem. 2007 Sep 19; 55(19):7732-7. Seeram NP, Aronson WJ, Zhang Y, Henning SM, Moro A, Lee RP, Sartippour M, Harris DM, Rettig M, Suchard MA, Pantuck AJ, Belldegrun A, Heber D. PMID: 17722872.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimals
    33. Epidermal growth factor receptor inhibition sensitizes renal cell carcinoma cells to the cytotoxic effects of bortezomib. Mol Cancer Ther. 2007 Jan; 6(1):61-9. An J, Rettig MB. PMID: 17237266.
      View in: PubMed   Mentions: 16     Fields:    
    34. Mechanism of von Hippel-Lindau protein-mediated suppression of nuclear factor kappa B activity. Mol Cell Biol. 2005 Sep; 25(17):7546-56. An J, Rettig MB. PMID: 16107702.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    35. VHL expression in renal cell carcinoma sensitizes to bortezomib (PS-341) through an NF-kappaB-dependent mechanism. Oncogene. 2005 Feb 24; 24(9):1563-70. An J, Fisher M, Rettig MB. PMID: 15608669.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    36. Age, body mass index, and serum prostate-specific antigen correlate with bone loss in men with prostate cancer not receiving androgen deprivation therapy. Urology. 2004 Aug; 64(2):335-40. Conde FA, Sarna L, Oka RK, Vredevoe DL, Rettig MB, Aronson WJ. PMID: 15302490.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    37. Maximal apoptosis of renal cell carcinoma by the proteasome inhibitor bortezomib is nuclear factor-kappaB dependent. Mol Cancer Ther. 2004 Jun; 3(6):727-36. An J, Sun Y, Fisher M, Rettig MB. PMID: 15210859.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    38. AKT activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression. J Biol Chem. 2004 Jan 23; 279(4):2737-46. Gera JF, Mellinghoff IK, Shi Y, Rettig MB, Tran C, Hsu JH, Sawyers CL, Lichtenstein AK. PMID: 14576155.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansCells
    39. Drug interactions between the proteasome inhibitor bortezomib and cytotoxic chemotherapy, tumor necrosis factor (TNF) alpha, and TNF-related apoptosis-inducing ligand in prostate cancer. Clin Cancer Res. 2003 Oct 01; 9(12):4537-45. An J, Sun YP, Adams J, Fisher M, Belldegrun A, Rettig MB. PMID: 14555528.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    40. Transcriptional coactivation of c-Jun by the KSHV-encoded LANA. Blood. 2004 Jan 01; 103(1):222-8. An J, Sun Y, Rettig MB. PMID: 12969971.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    41. Kaposi's sarcoma-associated herpesvirus encoded vFLIP induces cellular IL-6 expression: the role of the NF-kappaB and JNK/AP1 pathways. Oncogene. 2003 May 29; 22(22):3371-85. An J, Sun Y, Sun R, Rettig MB. PMID: 12776188.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    42. Rta of the human herpesvirus 8/Kaposi sarcoma-associated herpesvirus up-regulates human interleukin-6 gene expression. Blood. 2002 Sep 01; 100(5):1919-21. Deng H, Chu JT, Rettig MB, Martinez-Maza O, Sun R. PMID: 12176919.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    43. The Kaposi sarcoma-associated herpesvirus (KSHV) induces cellular interleukin 6 expression: role of the KSHV latency-associated nuclear antigen and the AP1 response element. Blood. 2002 Jan 15; 99(2):649-54. An J, Lichtenstein AK, Brent G, Rettig MB. PMID: 11781250.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
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