Daniel S Shin

Title(s)Assistant Professor-in-Residence, Medicine
SchoolMedicine
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    1. Targeting EZH2 to overcome the resistance to immunotherapy in lung cancer. Semin Oncol. 2022 Jul 02. Shin DS, Park K, Garon E, Dubinett S. PMID: 35851153.
      View in: PubMed   Mentions:    Fields:    
    2. Key Players of the Immunosuppressive Tumor Microenvironment and Emerging Therapeutic Strategies. Front Cell Dev Biol. 2022; 10:830208. Park K, Veena MS, Shin DS. PMID: 35345849; PMCID: PMC8957227.
      View in: PubMed   Mentions:
    3. Acute kidney injury in patients treated with immune checkpoint inhibitors. J Immunother Cancer. 2021 10; 9(10). Gupta S, Short SAP, Sise ME, Prosek JM, Madhavan SM, Soler MJ, Ostermann M, Herrmann SM, Abudayyeh A, Anand S, Glezerman I, Motwani SS, Murakami N, Wanchoo R, Ortiz-Melo DI, Rashidi A, Sprangers B, Aggarwal V, Malik AB, Loew S, Carlos CA, Chang WT, Beckerman P, Mithani Z, Shah CV, Renaghan AD, Seigneux S, Campedel L, Kitchlu A, Shin DS, Rangarajan S, Deshpande P, Coppock G, Eijgelsheim M, Seethapathy H, Lee MD, Strohbehn IA, Owen DH, Husain M, Garcia-Carro C, Bermejo S, Lumlertgul N, Seylanova N, Flanders L, Isik B, Mamlouk O, Lin JS, Garcia P, Kaghazchi A, Khanin Y, Kansal SK, Wauters E, Chandra S, Schmidt-Ott KM, Hsu RK, Tio MC, Sarvode Mothi S, Singh H, Schrag D, Jhaveri KD, Reynolds KL, Cortazar FB, Leaf DE, ICPi-AKI Consortium Investigators. PMID: 34625513; PMCID: PMC8496384.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    4. Osimertinib as neoadjuvant therapy in a patient with stage IIIA non-small cell lung cancer: a case report. J Med Case Rep. 2021 Apr 24; 15(1):216. Chen CY, Fares CM, Shin DS. PMID: 33892800; PMCID: PMC8066434.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Conserved Interferon-γ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma. Cancer Cell. 2021 Jan 11; 39(1):122. Grasso CS, Tsoi J, Onyshchenko M, Abril-Rodriguez G, Ross-Macdonald P, Wind-Rotolo M, Champhekar A, Medina E, Torrejon DY, Shin DS, Tran P, Kim YJ, Puig-Saus C, Campbell K, Vega-Crespo A, Quist M, Martignier C, Luke JJ, Wolchok JD, Johnson DB, Chmielowski B, Hodi FS, Bhatia S, Sharfman W, Urba WJ, Slingluff CL, Diab A, Haanen JBAG, Algarra SM, Pardoll DM, Anagnostou V, Topalian SL, Velculescu VE, Speiser DE, Kalbasi A, Ribas A. PMID: 33306984; PMCID: PMC7885306.
      View in: PubMed   Mentions: 8     Fields:    
    6. Dysregulation of hsa-miR-34a and hsa-miR-449a leads to overexpression of PACS-1 and loss of DNA damage response (DDR) in cervical cancer. J Biol Chem. 2020 12 11; 295(50):17169-17186. Veena MS, Raychaudhuri S, Basak SK, Venkatesan N, Kumar P, Biswas R, Chakrabarti R, Lu J, Su T, Gallagher-Jones M, Morselli M, Fu H, Pellegrini M, Goldstein T, Aladjem MI, Rettig MB, Wilczynski SP, Shin DS, Srivatsan ES. PMID: 33028635; PMCID: PMC7863911.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    7. Conserved Interferon-γ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma. Cancer Cell. 2020 10 12; 38(4):500-515.e3. Grasso CS, Tsoi J, Onyshchenko M, Abril-Rodriguez G, Ross-Macdonald P, Wind-Rotolo M, Champhekar A, Medina E, Torrejon DY, Shin DS, Tran P, Kim YJ, Puig-Saus C, Campbell K, Vega-Crespo A, Quist M, Martignier C, Luke JJ, Wolchok JD, Johnson DB, Chmielowski B, Hodi FS, Bhatia S, Sharfman W, Urba WJ, Slingluff CL, Diab A, Haanen JBAG, Algarra SM, Pardoll DM, Anagnostou V, Topalian SL, Velculescu VE, Speiser DE, Kalbasi A, Ribas A. PMID: 32916126; PMCID: PMC7872287.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
    8. A randomized, phase 1, placebo-controlled trial of APG-157 in oral cancer demonstrates systemic absorption and an inhibitory effect on cytokines and tumor-associated microbes. Cancer. 2020 04 15; 126(8):1668-1682. Basak SK, Bera A, Yoon AJ, Morselli M, Jeong C, Tosevska A, Dong TS, Eklund M, Russ E, Nasser H, Lagishetty V, Guo R, Sajed D, Mudgal S, Mehta P, Avila L, Srivastava M, Faull K, Jacobs J, Pellegrini M, Shin DS, Srivatsan ES, Wang MB. PMID: 32022261.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCTClinical Trials
    9. Clinical Features and Outcomes of Immune Checkpoint Inhibitor-Associated AKI: A Multicenter Study. J Am Soc Nephrol. 2020 02; 31(2):435-446. Cortazar FB, Kibbelaar ZA, Glezerman IG, Abudayyeh A, Mamlouk O, Motwani SS, Murakami N, Herrmann SM, Manohar S, Shirali AC, Kitchlu A, Shirazian S, Assal A, Vijayan A, Renaghan AD, Ortiz-Melo DI, Rangarajan S, Malik AB, Hogan JJ, Dinh AR, Shin DS, Marrone KA, Mithani Z, Johnson DB, Hosseini A, Uprety D, Sharma S, Gupta S, Reynolds KL, Sise ME, Leaf DE. PMID: 31896554; PMCID: PMC7003302.
      View in: PubMed   Mentions: 69     Fields:    Translation:Humans
    10. Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression. Cell Rep. 2019 Dec 10; 29(11):3766. Garcia-Diaz A, Shin DS, Moreno BH, Saco J, Escuin-Ordinas H, Rodriguez GA, Zaretsky JM, Sun L, Hugo W, Wang X, Parisi G, Saus CP, Torrejon DY, Graeber TG, Comin-Anduix B, Hu-Lieskovan S, Damoiseaux R, Lo RS, Ribas A. PMID: 31825850.
      View in: PubMed   Mentions: 24     Fields:    
    11. Global alteration of T-lymphocyte metabolism by PD-L1 checkpoint involves a block of de novo nucleoside phosphate synthesis. Cell Discov. 2019; 5:62. Palaskas NJ, Garcia JD, Shirazi R, Shin DS, Puig-Saus C, Braas D, Ribas A, Graeber TG. PMID: 31798961; PMCID: PMC6877514.
      View in: PubMed   Mentions: 8  
    12. Substitutions that lock and unlock the proton-coupled folate transporter (PCFT-SLC46A1) in an inward-open conformation. J Biol Chem. 2019 05 03; 294(18):7245-7258. Aluri S, Zhao R, Lin K, Shin DS, Fiser A, Goldman ID. PMID: 30858177; PMCID: PMC6509503.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    13. Genetic Mechanisms of Immune Evasion in Colorectal Cancer. Cancer Discov. 2018 06; 8(6):730-749. Grasso CS, Giannakis M, Wells DK, Hamada T, Mu XJ, Quist M, Nowak JA, Nishihara R, Qian ZR, Inamura K, Morikawa T, Nosho K, Abril-Rodriguez G, Connolly C, Escuin-Ordinas H, Geybels MS, Grady WM, Hsu L, Hu-Lieskovan S, Huyghe JR, Kim YJ, Krystofinski P, Leiserson MDM, Montoya DJ, Nadel BB, Pellegrini M, Pritchard CC, Puig-Saus C, Quist EH, Raphael BJ, Salipante SJ, Shin DS, Shinbrot E, Shirts B, Shukla S, Stanford JL, Sun W, Tsoi J, Upfill-Brown A, Wheeler DA, Wu CJ, Yu M, Zaidi SH, Zaretsky JM, Gabriel SB, Lander ES, Garraway LA, Hudson TJ, Fuchs CS, Ribas A, Ogino S, Peters U. PMID: 29510987; PMCID: PMC5984687.
      View in: PubMed   Mentions: 167     Fields:    Translation:HumansCells
    14. Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression. Cell Rep. 2017 05 09; 19(6):1189-1201. Garcia-Diaz A, Shin DS, Moreno BH, Saco J, Escuin-Ordinas H, Rodriguez GA, Zaretsky JM, Sun L, Hugo W, Wang X, Parisi G, Saus CP, Torrejon DY, Graeber TG, Comin-Anduix B, Hu-Lieskovan S, Damoiseaux R, Lo RS, Ribas A. PMID: 28494868; PMCID: PMC6420824.
      View in: PubMed   Mentions: 551     Fields:    Translation:HumansCells
    15. Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations. Cancer Discov. 2017 02; 7(2):188-201. Shin DS, Zaretsky JM, Escuin-Ordinas H, Garcia-Diaz A, Hu-Lieskovan S, Kalbasi A, Grasso CS, Hugo W, Sandoval S, Torrejon DY, Palaskas N, Rodriguez GA, Parisi G, Azhdam A, Chmielowski B, Cherry G, Seja E, Berent-Maoz B, Shintaku IP, Le DT, Pardoll DM, Diaz LA, Tumeh PC, Graeber TG, Lo RS, Comin-Anduix B, Ribas A. PMID: 27903500; PMCID: PMC5296316.
      View in: PubMed   Mentions: 463     Fields:    Translation:HumansCells
    16. Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma. N Engl J Med. 2016 Sep 01; 375(9):819-29. Zaretsky JM, Garcia-Diaz A, Shin DS, Escuin-Ordinas H, Hugo W, Hu-Lieskovan S, Torrejon DY, Abril-Rodriguez G, Sandoval S, Barthly L, Saco J, Homet Moreno B, Mezzadra R, Chmielowski B, Ruchalski K, Shintaku IP, Sanchez PJ, Puig-Saus C, Cherry G, Seja E, Kong X, Pang J, Berent-Maoz B, Comin-Anduix B, Graeber TG, Tumeh PC, Schumacher TN, Lo RS, Ribas A. PMID: 27433843; PMCID: PMC5007206.
      View in: PubMed   Mentions: 1124     Fields:    Translation:HumansCells
    17. Repurposing metformin for cancer treatment: current clinical studies. Oncotarget. 2016 Jun 28; 7(26):40767-40780. Chae YK, Arya A, Malecek MK, Shin DS, Carneiro B, Chandra S, Kaplan J, Kalyan A, Altman JK, Platanias L, Giles F. PMID: 27004404; PMCID: PMC5130043.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansAnimals
    18. Human Epidermal Growth Factor Receptor 2 (HER-2/neu)-Directed Therapy for Rare Metastatic Epithelial Tumors with HER-2 Amplification. Case Rep Oncol. 2016 May-Aug; 9(2):298-304. Shin DS, Sherry T, Kallen ME, Wong S, Drakaki A. PMID: 27403128; PMCID: PMC4924467.
      View in: PubMed   Mentions: 4  
    19. PD-1 Blockade Expands Intratumoral Memory T Cells. Cancer Immunol Res. 2016 Mar; 4(3):194-203. Ribas A, Shin DS, Zaretsky J, Frederiksen J, Cornish A, Avramis E, Seja E, Kivork C, Siebert J, Kaplan-Lefko P, Wang X, Chmielowski B, Glaspy JA, Tumeh PC, Chodon T, Pe'er D, Comin-Anduix B. PMID: 26787823; PMCID: PMC4775381.
      View in: PubMed   Mentions: 147     Fields:    Translation:HumansCellsCTClinical Trials
    20. Romiplostim mitigates dose-limiting thrombocytopenia of erucic acid for adrenomyeloneuropathy. Br J Haematol. 2015 Dec; 171(5):879-81. Shin DS, Perlman S, Rosove MH. PMID: 25854532.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    21. The evolution of checkpoint blockade as a cancer therapy: what's here, what's next? Curr Opin Immunol. 2015 Apr; 33:23-35. Shin DS, Ribas A. PMID: 25621841.
      View in: PubMed   Mentions: 145     Fields:    Translation:HumansAnimalsCells
    22. Metastatic human epidermal growth factor 2 (HER2/neu) amplified breast cancer with acute fulminant hepatitis responding to trastuzumab, pertuzumab and carboplatin. BMJ Case Rep. 2014 Jun 04; 2014. Macias MN, Shin DS, Ledezma B, Sadeghi S. PMID: 24899001; PMCID: PMC4054489.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    23. Role of the fourth transmembrane domain in proton-coupled folate transporter function as assessed by the substituted cysteine accessibility method. Am J Physiol Cell Physiol. 2013 Jun 15; 304(12):C1159-67. Shin DS, Zhao R, Fiser A, Goldman ID. PMID: 23552283; PMCID: PMC3680650.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    24. Functional roles of the A335 and G338 residues of the proton-coupled folate transporter (PCFT-SLC46A1) mutated in hereditary folate malabsorption. Am J Physiol Cell Physiol. 2012 Oct 15; 303(8):C834-42. Shin DS, Zhao R, Fiser A, Goldman DI. PMID: 22843796; PMCID: PMC3469714.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    25. Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1). Am J Physiol Cell Physiol. 2012 Sep 15; 303(6):C673-81. Zhao R, Shin DS, Fiser A, Goldman ID. PMID: 22785121; PMCID: PMC3468349.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    26. A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding. Am J Physiol Cell Physiol. 2012 May 01; 302(9):C1405-12. Shin DS, Zhao R, Yap EH, Fiser A, Goldman ID. PMID: 22345511; PMCID: PMC3361945.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    27. Random mutagenesis of the proton-coupled folate transporter (SLC46A1), clustering of mutations, and the bases for associated losses of function. J Biol Chem. 2011 Jul 08; 286(27):24150-8. Zhao R, Shin DS, Diop-Bove N, Ovits CG, Goldman ID. PMID: 21602279; PMCID: PMC3129196.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    28. Identification of novel mutations in the proton-coupled folate transporter (PCFT-SLC46A1) associated with hereditary folate malabsorption. Mol Genet Metab. 2011 May; 103(1):33-7. Shin DS, Mahadeo K, Min SH, Diop-Bove N, Clayton P, Zhao R, Goldman ID. PMID: 21333572; PMCID: PMC3081934.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    29. Vulnerability of the cysteine-less proton-coupled folate transporter (PCFT-SLC46A1) to mutational stress associated with the substituted cysteine accessibility method. Biochim Biophys Acta. 2011 Apr; 1808(4):1140-5. Zhao R, Shin DS, Goldman ID. PMID: 21256110; PMCID: PMC3062655.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    30. Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption. Blood. 2010 Dec 09; 116(24):5162-9. Shin DS, Min SH, Russell L, Zhao R, Fiser A, Goldman ID. PMID: 20805364; PMCID: PMC3012536.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    31. Membrane topological analysis of the proton-coupled folate transporter (PCFT-SLC46A1) by the substituted cysteine accessibility method. Biochemistry. 2010 Apr 06; 49(13):2925-31. Zhao R, Unal ES, Shin DS, Goldman ID. PMID: 20225891; PMCID: PMC2866095.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
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