Thomas G Graeber

Title(s)Professor, Molecular and Medical Pharmacology
SchoolMedicine
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    Collapse Research 
    Collapse Research Activities and Funding
    Metabolic and epigenetic reprogramming of vital organs in SARS-CoV-2 induced systemic toxicity
    NIH R01DK132735Sep 17, 2021 - Aug 31, 2024
    Role: Co-Principal Investigator
    Targeting Genomic Instability in Lethal Neuroendocrine Prostate Cancer
    NIH R01CA222877Jun 6, 2018 - May 31, 2023
    Role: Principal Investigator
    Mammalian models for integrated metabolic and molecular profiling of malignant glioma
    NIH R01CA227089Jun 6, 2018 - May 31, 2023
    Role: Co-Principal Investigator
    Quantitative Mass Spectrometer for Targeted and Global Proteomics, Metabolomics
    NIH S10OD016387Jul 1, 2013 - Jun 30, 2014
    Role: Principal Investigator
    Diagnosing Emergence of Kinase Inhibitor Resistance on a Microchip
    NIH R21CA169993Aug 24, 2012 - Jul 31, 2014
    Role: Principal Investigator
    Profiling of Protein Modifications by Mass Spectrometry
    NIH K22HG002807May 12, 2003 - Mar 31, 2008
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The metabolic cofactor Coenzyme A enhances alternative macrophage activation via MyD88-linked signaling. bioRxiv. 2024 Mar 31. Jones AE, Rios A, Ibrahimovic N, Chavez C, Bayley NA, Ball AB, Hsieh WY, Sammarco A, Bianchi AR, Cortez AA, Graeber TG, Hoffmann A, Bensinger SJ, Divakaruni AS. PMID: 38585887; PMCID: PMC10996702.
      View in: PubMed   Mentions:
    2. Host immunity contributes to the anti-melanoma activity of BRAF inhibitors. J Clin Invest. 2023 Dec 15; 133(24). Knight DA, Ngiow SF, Li M, Parmenter T, Mok S, Cass A, Haynes NM, Kinross K, Yagita H, Koya RC, Graeber TG, Ribas A, McArthur GA, Smyth MJ. PMID: 38099495; PMCID: PMC10721136.
      View in: PubMed   Mentions:    Fields:    
    3. Temporal evolution reveals bifurcated lineages in aggressive neuroendocrine small cell prostate cancer trans-differentiation. Cancer Cell. 2023 12 11; 41(12):2066-2082.e9. Chen CC, Tran W, Song K, Sugimoto T, Obusan MB, Wang L, Sheu KM, Cheng D, Ta L, Varuzhanyan G, Huang A, Xu R, Zeng Y, Borujerdpur A, Bayley NA, Noguchi M, Mao Z, Morrissey C, Corey E, Nelson PS, Zhao Y, Huang J, Park JW, Witte ON, Graeber TG. PMID: 37995683; PMCID: PMC10878415.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    4. Telomerase reverse transcriptase induces targetable alterations in glutathione and nucleotide biosynthesis in glioblastomas. bioRxiv. 2023 Nov 16. Udutha S, Taglang C, Batsios G, Gillespie AM, Tran M, Ronen SM, Ten Hoeve J, Graeber TG, Viswanath P. PMID: 38014170; PMCID: PMC10680720.
      View in: PubMed   Mentions:
    5. MITF regulates IDH1 and NNT and drives a transcriptional program protecting cutaneous melanoma from reactive oxygen species. bioRxiv. 2023 Nov 14. Roider E, Lakatos AIT, McConnell AM, Wang P, Mueller A, Kawakami A, Tsoi J, Szabolcs BL, Ascsillán AA, Suita Y, Igras V, Lo JA, Hsiao JJ, Lapides R, Pál DMP, Lengyel AS, Navarini A, Okazaki A, Iliopoulos O, Németh I, Graeber TG, Zon L, Giese RW, Kemeny LV, Fisher DE. PMID: 38014031; PMCID: PMC10680652.
      View in: PubMed   Mentions:
    6. A ketogenic diet can mitigate SARS-CoV-2 induced systemic reprogramming and inflammation. Commun Biol. 2023 11 03; 6(1):1115. Palermo A, Li S, Ten Hoeve J, Chellappa A, Morris A, Dillon B, Ma F, Wang Y, Cao E, Shabane B, Acín-Perez R, Petcherski A, Lusis AJ, Hazen S, Shirihai OS, Pellegrini M, Arumugaswami V, Graeber TG, Deb A. PMID: 37923961; PMCID: PMC10624922.
      View in: PubMed   Mentions: Translation:AnimalsCells
    7. Fibroblast Activation Protein Expression in Sarcomas. Sarcoma. 2023; 2023:2480493. Crane JN, Graham DS, Mona CE, Nelson SD, Samiei A, Dawson DW, Dry SM, Masri MG, Crompton JG, Benz MR, Czernin J, Eilber FC, Graeber TG, Calais J, Federman NC. PMID: 37333052; PMCID: PMC10275689.
      View in: PubMed   Mentions:
    8. CDKN2A deletion remodels lipid metabolism to prime glioblastoma for ferroptosis. Cancer Cell. 2023 06 12; 41(6):1048-1060.e9. Minami JK, Morrow D, Bayley NA, Fernandez EG, Salinas JJ, Tse C, Zhu H, Su B, Plawat R, Jones A, Sammarco A, Liau LM, Graeber TG, Williams KJ, Cloughesy TF, Dixon SJ, Bensinger SJ, Nathanson DA. PMID: 37236196; PMCID: PMC10330677.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    9. Tumor heterogeneity in VHL drives metastasis in clear cell renal cell carcinoma. Signal Transduct Target Ther. 2023 04 17; 8(1):155. Hu J, Tan P, Ishihara M, Bayley NA, Schokrpur S, Reynoso JG, Zhang Y, Lim RJ, Dumitras C, Yang L, Dubinett SM, Jat PS, Van Snick J, Huang J, Chin AI, Prins RM, Graeber TG, Xu H, Wu L. PMID: 37069149; PMCID: PMC10110583.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    10. Targeting PEA3 transcription factors to mitigate small cell lung cancer progression. Oncogene. 2023 02; 42(6):434-448. Shia DW, Choi W, Vijayaraj P, Vuong V, Sandlin JM, Lu MM, Aziz A, Marin C, Aros CJ, Sen C, Durra A, Lund AJ, Purkayastha A, Rickabaugh TM, Graeber TG, Gomperts BN. PMID: 36509998; PMCID: PMC9898033.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    11. Primary and metastatic tumors exhibit systems-level differences in dependence on mitochondrial respiratory function. PLoS Biol. 2022 09; 20(9):e3001753. Bennett NK, Nakaoka HJ, Laurent D, Okimoto RA, Sei Y, Horvai AE, Bivona TG, Ten Hoeve J, Graeber TG, Nakamura K, Nakamura JL. PMID: 36137002; PMCID: PMC9498964.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    12. Plasticity of Extrachromosomal and Intrachromosomal BRAF Amplifications in Overcoming Targeted Therapy Dosage Challenges. Cancer Discov. 2022 04 01; 12(4):1046-1069. Song K, Minami JK, Huang A, Dehkordi SR, Lomeli SH, Luebeck J, Goodman MH, Moriceau G, Krijgsman O, Dharanipragada P, Ridgley T, Crosson WP, Salazar J, Pazol E, Karin G, Jayaraman R, Balanis NG, Alhani S, Sheu K, Ten Hoeve J, Palermo A, Motika SE, Senaratne TN, Paraiso KH, Hergenrother PJ, Rao PN, Multani AS, Peeper DS, Bafna V, Lo RS, Graeber TG. PMID: 34930786; PMCID: PMC9192483.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    13. Cardiomyocytes disrupt pyrimidine biosynthesis in nonmyocytes to regulate heart repair. J Clin Invest. 2022 01 18; 132(2). Li S, Yokota T, Wang P, Ten Hoeve J, Ma F, Le TM, Abt ER, Zhou Y, Wu R, Nanthavongdouangsy M, Rodriguez A, Wang Y, Lin YJ, Muranaka H, Sharpley M, Braddock DT, MacRae VE, Banerjee U, Chiou PY, Seldin M, Huang D, Teitell M, Gertsman I, Jung M, Bensinger SJ, Damoiseaux R, Faull K, Pellegrini M, Lusis AJ, Graeber TG, Radu CG, Deb A. PMID: 34813507; PMCID: PMC8759793.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    14. Measuring the scientific effectiveness of contact tracing: Evidence from a natural experiment. Proc Natl Acad Sci U S A. 2021 08 17; 118(33). Fetzer T, Graeber T. PMID: 34385318; PMCID: PMC8380024.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCellsPHPublic Health
    15. Melanoma dedifferentiation induced by IFN-γ epigenetic remodeling in response to anti-PD-1 therapy. J Clin Invest. 2021 06 15; 131(12). Kim YJ, Sheu KM, Tsoi J, Abril-Rodriguez G, Medina E, Grasso CS, Torrejon DY, Champhekar AS, Litchfield K, Swanton C, Speiser DE, Scumpia PO, Hoffmann A, Graeber TG, Puig-Saus C, Ribas A. PMID: 33914706; PMCID: PMC8203459.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    16. Confidence and central tendency in perceptual judgment. Atten Percept Psychophys. 2021 Oct; 83(7):3024-3034. Xiang Y, Graeber T, Enke B, Gershman SJ. PMID: 33890239.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    17. Metabolic reprogramming and epigenetic changes of vital organs in SARS-CoV-2-induced systemic toxicity. JCI Insight. 2021 01 25; 6(2). Li S, Ma F, Yokota T, Garcia G, Palermo A, Wang Y, Farrell C, Wang YC, Wu R, Zhou Z, Pan C, Morselli M, Teitell MA, Ryazantsev S, Fishbein GA, Hoeve JT, Arboleda VA, Bloom J, Dillon B, Pellegrini M, Lusis AJ, Graeber TG, Arumugaswami V, Deb A. PMID: 33284134; PMCID: PMC7934846.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    18. Intracellular C4BPA Levels Regulate NF-κB-Dependent Apoptosis. iScience. 2020 Oct 23; 23(10):101594. Olcina MM, Kim RK, Balanis NG, Li CG, von Eyben R, Graeber TG, Ricklin D, Stucki M, Giaccia AJ. PMID: 33205012; PMCID: PMC7648136.
      View in: PubMed   Mentions: 7  
    19. Defining the ATPome reveals cross-optimization of metabolic pathways. Nat Commun. 2020 08 28; 11(1):4319. Bennett NK, Nguyen MK, Darch MA, Nakaoka HJ, Cousineau D, Ten Hoeve J, Graeber TG, Schuelke M, Maltepe E, Kampmann M, Mendelsohn BA, Nakamura JL, Nakamura K. PMID: 32859923; PMCID: PMC7455733.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    20. Thermodynamic energetics underlying genomic instability and whole-genome doubling in cancer. Proc Natl Acad Sci U S A. 2020 08 04; 117(31):18880-18890. Remacle F, Graeber TG, Levine RD. PMID: 32694208; PMCID: PMC7414060.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    21. Integrin α6 mediates the drug resistance of acute lymphoblastic B-cell leukemia. Blood. 2020 07 09; 136(2):210-223. Gang EJ, Kim HN, Hsieh YT, Ruan Y, Ogana HA, Lee S, Pham J, Geng H, Park E, Klemm L, Willman CL, Carroll WL, Mittelman SD, Orgel E, Oberley MJ, Parekh C, Abdel-Azim H, Bhojwani D, Wayne AS, De Arcangelis A, Georges-Labouesse E, Wayner E, Bonig H, Minasyan A, Ten Hoeve J, Graeber TG, Müschen M, Heisterkamp N, Kim YM. PMID: 32219444; PMCID: PMC7357190.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    22. Somatic copy number profiling from hepatocellular carcinoma circulating tumor cells. NPJ Precis Oncol. 2020; 4:16. Court CM, Hou S, Liu L, Winograd P, DiPardo BJ, Liu SX, Chen PJ, Zhu Y, Smalley M, Zhang R, Sadeghi S, Finn RS, Kaldas FM, Busuttil RW, Zhou XJ, Tseng HR, Tomlinson JS, Graeber TG, Agopian VG. PMID: 32637655; PMCID: PMC7331695.
      View in: PubMed   Mentions: 8  
    23. Delayed negative effects of prosocial spending on happiness. Proc Natl Acad Sci U S A. 2020 03 24; 117(12):6463-6468. Falk A, Graeber T. PMID: 32152104; PMCID: PMC7161742.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    24. A genetically defined disease model reveals that urothelial cells can initiate divergent bladder cancer phenotypes. Proc Natl Acad Sci U S A. 2020 01 07; 117(1):563-572. Wang L, Smith BA, Balanis NG, Tsai BL, Nguyen K, Cheng MW, Obusan MB, Esedebe FN, Patel SJ, Zhang H, Clark PM, Sisk AE, Said JW, Huang J, Graeber TG, Witte ON, Chin AI, Park JW. PMID: 31871155; PMCID: PMC6955337.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    25. Modeling Progressive Fibrosis with Pluripotent Stem Cells Identifies an Anti-fibrotic Small Molecule. Cell Rep. 2019 12 10; 29(11):3488-3505.e9. Vijayaraj P, Minasyan A, Durra A, Karumbayaram S, Mehrabi M, Aros CJ, Ahadome SD, Shia DW, Chung K, Sandlin JM, Darmawan KF, Bhatt KV, Manze CC, Paul MK, Wilkinson DC, Yan W, Clark AT, Rickabaugh TM, Wallace WD, Graeber TG, Damoiseaux R, Gomperts BN. PMID: 31825831; PMCID: PMC6927560.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    26. Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression. Cell Rep. 2019 Dec 10; 29(11):3766. Garcia-Diaz A, Shin DS, Moreno BH, Saco J, Escuin-Ordinas H, Rodriguez GA, Zaretsky JM, Sun L, Hugo W, Wang X, Parisi G, Saus CP, Torrejon DY, Graeber TG, Comin-Anduix B, Hu-Lieskovan S, Damoiseaux R, Lo RS, Ribas A. PMID: 31825850.
      View in: PubMed   Mentions: 54     Fields:    
    27. Global alteration of T-lymphocyte metabolism by PD-L1 checkpoint involves a block of de novo nucleoside phosphate synthesis. Cell Discov. 2019; 5:62. Palaskas NJ, Garcia JD, Shirazi R, Shin DS, Puig-Saus C, Braas D, Ribas A, Graeber TG. PMID: 31798961; PMCID: PMC6877514.
      View in: PubMed   Mentions: 12  
    28. Hyperoxia but not AOX expression mitigates pathological cardiac remodeling in a mouse model of inflammatory cardiomyopathy. Sci Rep. 2019 09 04; 9(1):12741. Dhandapani PK, Begines-Moreno IM, Brea-Calvo G, Gärtner U, Graeber TG, Javier Sanchez G, Morty RE, Schönig K, Hoeve JT, Wietelmann A, Braun T, Jacobs HT, Szibor M. PMID: 31484989; PMCID: PMC6726756.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    29. A linear mixed model approach to gene expression-tumor aneuploidy association studies. Sci Rep. 2019 08 16; 9(1):11944. Yao DW, Balanis NG, Eskin E, Graeber TG. PMID: 31420589; PMCID: PMC6697733.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    30. Pan-cancer Convergence to a Small-Cell Neuroendocrine Phenotype that Shares Susceptibilities with Hematological Malignancies. Cancer Cell. 2019 07 08; 36(1):17-34.e7. Balanis NG, Sheu KM, Esedebe FN, Patel SJ, Smith BA, Park JW, Alhani S, Gomperts BN, Huang J, Witte ON, Graeber TG. PMID: 31287989; PMCID: PMC6703903.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
    31. Ampk regulates IgD expression but not energy stress with B cell activation. Sci Rep. 2019 06 03; 9(1):8176. Waters LR, Ahsan FM, Ten Hoeve J, Hong JS, Kim DNH, Minasyan A, Braas D, Graeber TG, Zangle TA, Teitell MA. PMID: 31160601; PMCID: PMC6546716.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    32. Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases. Nature. 2019 05; 569(7758):655-662. Lloyd-Price J, Arze C, Ananthakrishnan AN, Schirmer M, Avila-Pacheco J, Poon TW, Andrews E, Ajami NJ, Bonham KS, Brislawn CJ, Casero D, Courtney H, Gonzalez A, Graeber TG, Hall AB, Lake K, Landers CJ, Mallick H, Plichta DR, Prasad M, Rahnavard G, Sauk J, Shungin D, Vázquez-Baeza Y, White RA, IBDMDB Investigators, Braun J, Denson LA, Jansson JK, Knight R, Kugathasan S, McGovern DPB, Petrosino JF, Stappenbeck TS, Winter HS, Clish CB, Franzosa EA, Vlamakis H, Xavier RJ, Huttenhower C. PMID: 31142855; PMCID: PMC6650278.
      View in: PubMed   Mentions: 927     Fields:    Translation:HumansAnimalsCells
    33. Interleukin 32 expression in human melanoma. J Transl Med. 2019 04 05; 17(1):113. Paz H, Tsoi J, Kalbasi A, Grasso CS, McBride WH, Schaue D, Butterfield LH, Maurer DM, Ribas A, Graeber TG, Economou JS. PMID: 30953519; PMCID: PMC6449995.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    34. Mutations in an Innate Immunity Pathway Are Associated with Poor Overall Survival Outcomes and Hypoxic Signaling in Cancer. Cell Rep. 2018 12 26; 25(13):3721-3732.e6. Olcina MM, Balanis NG, Kim RK, Aksoy BA, Kodysh J, Thompson MJ, Hammerbacher J, Graeber TG, Giaccia AJ. PMID: 30590044; PMCID: PMC6405289.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    35. Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage. Science. 2018 10 05; 362(6410):91-95. Park JW, Lee JK, Sheu KM, Wang L, Balanis NG, Nguyen K, Smith BA, Cheng C, Tsai BL, Cheng D, Huang J, Kurdistani SK, Graeber TG, Witte ON. PMID: 30287662; PMCID: PMC6414229.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansCells
    36. A Human Adult Stem Cell Signature Marks Aggressive Variants across Epithelial Cancers. Cell Rep. 2018 09 18; 24(12):3353-3366.e5. Smith BA, Balanis NG, Nanjundiah A, Sheu KM, Tsai BL, Zhang Q, Park JW, Thompson M, Huang J, Witte ON, Graeber TG. PMID: 30232014; PMCID: PMC6382070.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    37. Phosphopeptide Enrichment Coupled with Label-free Quantitative Mass Spectrometry to Investigate the Phosphoproteome in Prostate Cancer. J Vis Exp. 2018 08 02; (138). Cheng LC, Li Z, Graeber TG, Graham NA, Drake JM. PMID: 30124664; PMCID: PMC6126612.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    38. A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers. Cancer Metab. 2018; 6:7. Xu S, Catapang A, Braas D, Stiles L, Doh HM, Lee JT, Graeber TG, Damoiseaux R, Shirihai O, Herschman HR. PMID: 29988332; PMCID: PMC6022704.
      View in: PubMed   Mentions: 13  
    39. Hexokinase 2 is targetable for HK1 negative, HK2 positive tumors from a wide variety of tissues of origin. J Nucl Med. 2018 Jun 07. Xu S, Catapang A, Doh HM, Bayley NA, Lee JT, Braas D, Graeber TG, Herschman HR. PMID: 29880505; PMCID: PMC8833855.
      View in: PubMed   Mentions: 7     Fields:    
    40. Author Correction: Metabolic gatekeeper function of B-lymphoid transcription factors. Nature. 2018 06; 558(7711):E5. Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M. PMID: 29849140.
      View in: PubMed   Mentions:    Fields:    
    41. Making Mistakes Empowers Cancer Cells. Trends Cancer. 2018 07; 4(7):461-463. Balanis NG, Graeber TG. PMID: 29937042.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    42. The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma. Cancer Cell. 2018 05 14; 33(5):905-921.e5. Momcilovic M, Bailey ST, Lee JT, Fishbein MC, Braas D, Go J, Graeber TG, Parlati F, Demo S, Li R, Walser TC, Gricowski M, Shuman R, Ibarra J, Fridman D, Phelps ME, Badran K, St John M, Bernthal NM, Federman N, Yanagawa J, Dubinett SM, Sadeghi S, Christofk HR, Shackelford DB. PMID: 29763624; PMCID: PMC6451645.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    43. Systemic surfaceome profiling identifies target antigens for immune-based therapy in subtypes of advanced prostate cancer. Proc Natl Acad Sci U S A. 2018 05 08; 115(19):E4473-E4482. Lee JK, Bangayan NJ, Chai T, Smith BA, Pariva TE, Yun S, Vashisht A, Zhang Q, Park JW, Corey E, Huang J, Graeber TG, Wohlschlegel J, Witte ON. PMID: 29686080; PMCID: PMC5949005.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    44. Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities. Cancer Metab. 2018; 6:4. Garrett M, Sperry J, Braas D, Yan W, Le TM, Mottahedeh J, Ludwig K, Eskin A, Qin Y, Levy R, Breunig JJ, Pajonk F, Graeber TG, Radu CG, Christofk H, Prins RM, Lai A, Liau LM, Coppola G, Kornblum HI. PMID: 29692895; PMCID: PMC5905129.
      View in: PubMed   Mentions: 34  
    45. Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress. Cancer Cell. 2018 05 14; 33(5):890-904.e5. Tsoi J, Robert L, Paraiso K, Galvan C, Sheu KM, Lay J, Wong DJL, Atefi M, Shirazi R, Wang X, Braas D, Grasso CS, Palaskas N, Ribas A, Graeber TG. PMID: 29657129; PMCID: PMC5953834.
      View in: PubMed   Mentions: 335     Fields:    Translation:HumansCells
    46. B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies. Cell. 2018 04 05; 173(2):470-484.e18. Xiao G, Chan LN, Klemm L, Braas D, Chen Z, Geng H, Zhang QC, Aghajanirefah A, Cosgun KN, Sadras T, Lee J, Mirzapoiazova T, Salgia R, Ernst T, Hochhaus A, Jumaa H, Jiang X, Weinstock DM, Graeber TG, Müschen M. PMID: 29551267; PMCID: PMC6284818.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    47. Circulating Tumor Cells Predict Occult Metastatic Disease and Prognosis in Pancreatic Cancer. Ann Surg Oncol. 2018 Apr; 25(4):1000-1008. Court CM, Ankeny JS, Sho S, Winograd P, Hou S, Song M, Wainberg ZA, Girgis MD, Graeber TG, Agopian VG, Tseng HR, Tomlinson JS. PMID: 29442211; PMCID: PMC5896564.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    48. Single-cell analysis resolves the cell state transition and signaling dynamics associated with melanoma drug-induced resistance. Proc Natl Acad Sci U S A. 2017 12 26; 114(52):13679-13684. Su Y, Wei W, Robert L, Xue M, Tsoi J, Garcia-Diaz A, Homet Moreno B, Kim J, Ng RH, Lee JW, Koya RC, Comin-Anduix B, Graeber TG, Ribas A, Heath JR. PMID: 29229836; PMCID: PMC5748184.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansCells
    49. Lactate dehydrogenase activity drives hair follicle stem cell activation. Nat Cell Biol. 2017 Sep; 19(9):1017-1026. Flores A, Schell J, Krall AS, Jelinek D, Miranda M, Grigorian M, Braas D, White AC, Zhou JL, Graham NA, Graeber T, Seth P, Evseenko D, Coller HA, Rutter J, Christofk HR, Lowry WE. PMID: 28812580; PMCID: PMC5657543.
      View in: PubMed   Mentions: 110     Fields:    Translation:AnimalsCells
    50. Precision oncology using a limited number of cells: optimization of whole genome amplification products for sequencing applications. BMC Cancer. 2017 Jul 01; 17(1):457. Sho S, Court CM, Winograd P, Lee S, Hou S, Graeber TG, Tseng HR, Tomlinson JS. PMID: 28666423; PMCID: PMC5493892.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    51. Ibrutinib Unmasks Critical Role of Bruton Tyrosine Kinase in Primary CNS Lymphoma. Cancer Discov. 2017 09; 7(9):1018-1029. Grommes C, Pastore A, Palaskas N, Tang SS, Campos C, Schartz D, Codega P, Nichol D, Clark O, Hsieh WY, Rohle D, Rosenblum M, Viale A, Tabar VS, Brennan CW, Gavrilovic IT, Kaley TJ, Nolan CP, Omuro A, Pentsova E, Thomas AA, Tsyvkin E, Noy A, Palomba ML, Hamlin P, Sauter CS, Moskowitz CH, Wolfe J, Dogan A, Won M, Glass J, Peak S, Lallana EC, Hatzoglou V, Reiner AS, Gutin PH, Huse JT, Panageas KS, Graeber TG, Schultz N, DeAngelis LM, Mellinghoff IK. PMID: 28619981; PMCID: PMC5581705.
      View in: PubMed   Mentions: 148     Fields:    Translation:HumansCTClinical Trials
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    103. An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity. Cancer Res. 2013 May 01; 73(9):2850-62. Williams KJ, Argus JP, Zhu Y, Wilks MQ, Marbois BN, York AG, Kidani Y, Pourzia AL, Akhavan D, Lisiero DN, Komisopoulou E, Henkin AH, Soto H, Chamberlain BT, Vergnes L, Jung ME, Torres JZ, Liau LM, Christofk HR, Prins RM, Mischel PS, Reue K, Graeber TG, Bensinger SJ. PMID: 23440422; PMCID: PMC3919498.
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    104. Host immunity contributes to the anti-melanoma activity of BRAF inhibitors. J Clin Invest. 2013 Mar; 123(3):1371-81. Knight DA, Ngiow SF, Li M, Parmenter T, Mok S, Cass A, Haynes NM, Kinross K, Yagita H, Koya RC, Graeber TG, Ribas A, McArthur GA, Smyth MJ. PMID: 23454771; PMCID: PMC3582139.
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    105. Phosphoproteomic analysis of aortic endothelial cells activated by oxidized phospholipids. Methods Mol Biol. 2013; 1000:53-69. Zimman A, Berliner JA, Graeber TG. PMID: 23585084.
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    106. Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death. Mol Syst Biol. 2012 Jun 26; 8:589. Graham NA, Tahmasian M, Kohli B, Komisopoulou E, Zhu M, Vivanco I, Teitell MA, Wu H, Ribas A, Lo RS, Mellinghoff IK, Mischel PS, Graeber TG. PMID: 22735335; PMCID: PMC3397414.
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    107. BRAF inhibitor vemurafenib improves the antitumor activity of adoptive cell immunotherapy. Cancer Res. 2012 Aug 15; 72(16):3928-37. Koya RC, Mok S, Otte N, Blacketor KJ, Comin-Anduix B, Tumeh PC, Minasyan A, Graham NA, Graeber TG, Chodon T, Ribas A. PMID: 22693252; PMCID: PMC3422880.
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    108. NOD2 triggers an interleukin-32-dependent human dendritic cell program in leprosy. Nat Med. 2012 Mar 25; 18(4):555-63. Schenk M, Krutzik SR, Sieling PA, Lee DJ, Teles RM, Ochoa MT, Komisopoulou E, Sarno EN, Rea TH, Graeber TG, Kim S, Cheng G, Modlin RL. PMID: 22447076; PMCID: PMC3348859.
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    109. Determining PTEN functional status by network component deduced transcription factor activities. PLoS One. 2012; 7(2):e31053. Tran LM, Chang CJ, Plaisier S, Wu S, Dang J, Mischel PS, Liao JC, Graeber TG, Wu H. PMID: 22347425; PMCID: PMC3275574.
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    110. MicroRNA-21 targets the vitamin D-dependent antimicrobial pathway in leprosy. Nat Med. 2012 Jan 29; 18(2):267-73. Liu PT, Wheelwright M, Teles R, Komisopoulou E, Edfeldt K, Ferguson B, Mehta MD, Vazirnia A, Rea TH, Sarno EN, Graeber TG, Modlin RL. PMID: 22286305; PMCID: PMC3274599.
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    111. Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression. Proc Natl Acad Sci U S A. 2012 Jan 31; 109(5):1643-8. Drake JM, Graham NA, Stoyanova T, Sedghi A, Goldstein AS, Cai H, Smith DA, Zhang H, Komisopoulou E, Huang J, Graeber TG, Witte ON. PMID: 22307624; PMCID: PMC3277127.
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    112. RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature. 2011 Nov 23; 480(7377):387-90. Poulikakos PI, Persaud Y, Janakiraman M, Kong X, Ng C, Moriceau G, Shi H, Atefi M, Titz B, Gabay MT, Salton M, Dahlman KB, Tadi M, Wargo JA, Flaherty KT, Kelley MC, Misteli T, Chapman PB, Sosman JA, Graeber TG, Ribas A, Lo RS, Rosen N, Solit DB. PMID: 22113612; PMCID: PMC3266695.
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    113. A metaproteomic approach to study human-microbial ecosystems at the mucosal luminal interface. PLoS One. 2011; 6(11):e26542. Li X, LeBlanc J, Truong A, Vuthoori R, Chen SS, Lustgarten JL, Roth B, Allard J, Ippoliti A, Presley LL, Borneman J, Bigbee WL, Gopalakrishnan V, Graeber TG, Elashoff D, Braun J, Goodglick L. PMID: 22132074; PMCID: PMC3221670.
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    114. An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance. Genes Dev. 2011 Aug 01; 25(15):1628-40. Zuber J, Rappaport AR, Luo W, Wang E, Chen C, Vaseva AV, Shi J, Weissmueller S, Fellmann C, Fellman C, Taylor MJ, Weissenboeck M, Graeber TG, Kogan SC, Vakoc CR, Lowe SW. PMID: 21828272; PMCID: PMC3182026.
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    115. 18F-fluorodeoxy-glucose positron emission tomography marks MYC-overexpressing human basal-like breast cancers. Cancer Res. 2011 Aug 01; 71(15):5164-74. Palaskas N, Larson SM, Schultz N, Komisopoulou E, Wong J, Rohle D, Campos C, Yannuzzi N, Osborne JR, Linkov I, Kastenhuber ER, Taschereau R, Plaisier SB, Tran C, Heguy A, Wu H, Sander C, Phelps ME, Brennan C, Port E, Huse JT, Graeber TG, Mellinghoff IK. PMID: 21646475; PMCID: PMC3148325.
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    116. Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth. Cancer Cell. 2011 Jun 14; 19(6):792-804. Mulholland DJ, Tran LM, Li Y, Cai H, Morim A, Wang S, Plaisier S, Garraway IP, Huang J, Graeber TG, Wu H. PMID: 21620777; PMCID: PMC3157296.
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    117. BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition. Nature. 2011 May 19; 473(7347):384-8. Duy C, Hurtz C, Shojaee S, Cerchietti L, Geng H, Swaminathan S, Klemm L, Kweon SM, Nahar R, Braig M, Park E, Kim YM, Hofmann WK, Herzog S, Jumaa H, Koeffler HP, Yu JJ, Heisterkamp N, Graeber TG, Wu H, Ye BH, Melnick A, Müschen M. PMID: 21593872; PMCID: PMC3597744.
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    118. Global phosphoproteomics reveals crosstalk between Bcr-Abl and negative feedback mechanisms controlling Src signaling. Sci Signal. 2011 Mar 29; 4(166):ra18. Rubbi L, Titz B, Brown L, Galvan E, Komisopoulou E, Chen SS, Low T, Tahmasian M, Skaggs B, Müschen M, Pellegrini M, Graeber TG. PMID: 21447799; PMCID: PMC4057100.
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    119. The impact of ex vivo clinical grade activation protocols on human T-cell phenotype and function for the generation of genetically modified cells for adoptive cell transfer therapy. J Immunother. 2010 Oct; 33(8):759-68. Tumeh PC, Koya RC, Chodon T, Graham NA, Graeber TG, Comin-Anduix B, Ribas A. PMID: 20842061; PMCID: PMC3114626.
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    120. Integrated microfluidic and imaging platform for a kinase activity radioassay to analyze minute patient cancer samples. Cancer Res. 2010 Nov 01; 70(21):8299-308. Fang C, Wang Y, Vu NT, Lin WY, Hsieh YT, Rubbi L, Phelps ME, Müschen M, Kim YM, Chatziioannou AF, Tseng HR, Graeber TG. PMID: 20837665; PMCID: PMC3989903.
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    121. Rank-rank hypergeometric overlap: identification of statistically significant overlap between gene-expression signatures. Nucleic Acids Res. 2010 Sep; 38(17):e169. Plaisier SB, Taschereau R, Wong JA, Graeber TG. PMID: 20660011; PMCID: PMC2943622.
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    122. A microfluidic platform for systems pathology: multiparameter single-cell signaling measurements of clinical brain tumor specimens. Cancer Res. 2010 Aug 01; 70(15):6128-38. Sun J, Masterman-Smith MD, Graham NA, Jiao J, Mottahedeh J, Laks DR, Ohashi M, DeJesus J, Kamei K, Lee KB, Wang H, Yu ZT, Lu YT, Hou S, Li K, Liu M, Zhang N, Wang S, Angenieux B, Panosyan E, Samuels ER, Park J, Williams D, Konkankit V, Nathanson D, van Dam RM, Phelps ME, Wu H, Liau LM, Mischel PS, Lazareff JA, Kornblum HI, Yong WH, Graeber TG, Tseng HR. PMID: 20631065; PMCID: PMC3163840.
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    123. Activation of aortic endothelial cells by oxidized phospholipids: a phosphoproteomic analysis. J Proteome Res. 2010 Jun 04; 9(6):2812-24. Zimman A, Chen SS, Komisopoulou E, Titz B, Martínez-Pinna R, Kafi A, Berliner JA, Graeber TG. PMID: 20307106; PMCID: PMC2922471.
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    124. Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients. Cancer Res. 2009 Sep 01; 69(17):6889-98. Lu KV, Zhu S, Cvrljevic A, Huang TT, Sarkaria S, Ahkavan D, Dang J, Dinca EB, Plaisier SB, Oderberg I, Lee Y, Chen Z, Caldwell JS, Xie Y, Loo JA, Seligson D, Chakravari A, Lee FY, Weinmann R, Cloughesy TF, Nelson SF, Bergers G, Graeber T, Furnari FB, James CD, Cavenee WK, Johns TG, Mischel PS. PMID: 19690143; PMCID: PMC2770839.
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    125. Phosphorylation of the ATP-binding loop directs oncogenicity of drug-resistant BCR-ABL mutants. Proc Natl Acad Sci U S A. 2006 Dec 19; 103(51):19466-71. Skaggs BJ, Gorre ME, Ryvkin A, Burgess MR, Xie Y, Han Y, Komisopoulou E, Brown LM, Loo JA, Landaw EM, Sawyers CL, Graeber TG. PMID: 17164333; PMCID: PMC1698443.
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    126. Vascular endothelial growth factor receptor 2 plays a role in the activation of aortic endothelial cells by oxidized phospholipids. Arterioscler Thromb Vasc Biol. 2007 Feb; 27(2):332-8. Zimman A, Mouillesseaux KP, Le T, Gharavi NM, Ryvkin A, Graeber TG, Chen TT, Watson AD, Berliner JA. PMID: 17110601.
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    127. TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells. Nat Med. 2005 Jun; 11(6):653-60. Krutzik SR, Tan B, Li H, Ochoa MT, Liu PT, Sharfstein SE, Graeber TG, Sieling PA, Liu YJ, Rea TH, Bloom BR, Modlin RL. PMID: 15880118; PMCID: PMC1409736.
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    128. Cross-species comparisons of cancer signaling. Nat Genet. 2005 Jan; 37(1):7-8. Graeber TG, Sawyers CL. PMID: 15624012.
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    129. Visualization and interpretation of protein networks in Mycobacterium tuberculosis based on hierarchical clustering of genome-wide functional linkage maps. Nucleic Acids Res. 2003 Dec 15; 31(24):7099-109. Strong M, Graeber TG, Beeby M, Pellegrini M, Thompson MJ, Yeates TO, Eisenberg D. PMID: 14654685; PMCID: PMC291866.
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    130. Use of genetic profiling in leprosy to discriminate clinical forms of the disease. Science. 2003 Sep 12; 301(5639):1527-30. Bleharski JR, Li H, Meinken C, Graeber TG, Ochoa MT, Yamamura M, Burdick A, Sarno EN, Wagner M, Röllinghoff M, Rea TH, Colonna M, Stenger S, Bloom BR, Eisenberg D, Modlin RL. PMID: 12970564.
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    131. Myc-driven murine prostate cancer shares molecular features with human prostate tumors. Cancer Cell. 2003 Sep; 4(3):223-38. Ellwood-Yen K, Graeber TG, Wongvipat J, Iruela-Arispe ML, Zhang J, Matusik R, Thomas GV, Sawyers CL. PMID: 14522256.
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    132. Heterogeneity of molecular targets on clonal cancer lines derived from a novel hormone-refractory prostate cancer tumor system. Prostate. 2003 Jun 01; 55(4):299-307. Freedland SJ, Pantuck AJ, Paik SH, Zisman A, Graeber TG, Eisenberg D, McBride WH, Nguyen D, Tso CL, Belldegrun AS. PMID: 12712409.
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    133. Gene expression in epithelial ovarian carcinoma. Oncogene. 2002 Sep 12; 21(41):6289-98. Matei D, Graeber TG, Baldwin RL, Karlan BY, Rao J, Chang DD. PMID: 12214269.
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