David B Shackelford

Title(s)Associate Professor-in-Residence, Medicine
SchoolMedicine
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    (PQ5) Imaging mitochondrial heterogeneity in LKB1 mutant lung cancer
    NIH R01CA208642Sep 1, 2016 - Aug 31, 2021
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Modular polymer platform as a novel approach to head and neck cancer therapy. Sci Rep. 2022 03 04; 12(1):3592. Alhiyari Y, Shao J, Han AY, Miller A, Krane JF, Luff M, Momcilovic M, Shackelford D, Gu Z, John MAS. PMID: 35246558; PMCID: PMC8897426.
      View in: PubMed   Mentions:
    2. LKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer. Nat Commun. 2022 02 28; 13(1):1090. Murray CW, Brady JJ, Han M, Cai H, Tsai MK, Pierce SE, Cheng R, Demeter J, Feldser DM, Jackson PK, Shackelford DB, Winslow MM. PMID: 35228570; PMCID: PMC8885825.
      View in: PubMed   Mentions:
    3. What is the current role of immunotherapy in EGFR mutant advanced NSCLC? Lung Cancer. 2021 Dec 24. Velez MA, Tsai HHC, Shackelford DB, Garon EB, Lisberg A. PMID: 35031176.
      View in: PubMed   Mentions:
    4. Metabolic Phenotypes, Dependencies, and Adaptation in Lung Cancer. Cold Spring Harb Perspect Med. 2021 11 01; 11(11). DeNicola GM, Shackelford DB. PMID: 34127512; PMCID: PMC8559540.
      View in: PubMed   Mentions:
    5. Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors. Cell Chem Biol. 2022 Mar 17; 29(3):423-435.e10. Olszewski K, Barsotti A, Feng XJ, Momcilovic M, Liu KG, Kim JI, Morris K, Lamarque C, Gaffney J, Yu X, Patel JP, Rabinowitz JD, Shackelford DB, Poyurovsky MV. PMID: 34715056.
      View in: PubMed   Mentions:
    6. Inhibition of Granulocytic Myeloid-Derived Suppressor Cells Overcomes Resistance to Immune Checkpoint Inhibition in LKB1-Deficient Non-Small Cell Lung Cancer. Cancer Res. 2021 06 15; 81(12):3295-3308. Li R, Salehi-Rad R, Crosson W, Momcilovic M, Lim RJ, Ong SL, Huang ZL, Zhang T, Abascal J, Dumitras C, Jing Z, Park SJ, Krysan K, Shackelford DB, Tran LM, Liu B, Dubinett SM. PMID: 33853830; PMCID: PMC8776246.
      View in: PubMed   Mentions:    Fields:    
    7. SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition. Nat Commun. 2021 03 25; 12(1):1876. Mullen PJ, Garcia G, Purkayastha A, Matulionis N, Schmid EW, Momcilovic M, Sen C, Langerman J, Ramaiah A, Shackelford DB, Damoiseaux R, French SW, Plath K, Gomperts BN, Arumugaswami V, Christofk HR. PMID: 33767183; PMCID: PMC7994801.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    8. Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth. Cell Metab. 2021 05 04; 33(5):1013-1026.e6. Krall AS, Mullen PJ, Surjono F, Momcilovic M, Schmid EW, Halbrook CJ, Thambundit A, Mittelman SD, Lyssiotis CA, Shackelford DB, Knott SRV, Christofk HR. PMID: 33609439; PMCID: PMC8102379.
      View in: PubMed   Mentions: 8     Fields:    
    9. Novel Kras-mutant murine models of non-small cell lung cancer possessing co-occurring oncogenic mutations and increased tumor mutational burden. Cancer Immunol Immunother. 2021 Aug; 70(8):2389-2400. Salehi-Rad R, Li R, Tran LM, Lim RJ, Abascal J, Momcilovic M, Park SJ, Ong SL, Shabihkhani M, Huang ZL, Paul M, Shackelford DB, Krysan K, Liu B, Dubinett SM. PMID: 33507343; PMCID: PMC8289771.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    10. Durable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Antitumor T-cell Immunity. Cancer Discov. 2021 03; 11(3):714-735. Hong A, Piva M, Liu S, Hugo W, Lomeli SH, Zoete V, Randolph CE, Yang Z, Wang Y, Lee JJ, Lo SJ, Sun L, Vega-Crespo A, Garcia AJ, Shackelford DB, Dubinett SM, Scumpia PO, Byrum SD, Tackett AJ, Donahue TR, Michielin O, Holmen SL, Ribas A, Moriceau G, Lo RS. PMID: 33318037; PMCID: PMC7933113.
      View in: PubMed   Mentions: 2     Fields:    
    11. Phase 1 Trial of MLN0128 (Sapanisertib) and CB-839 HCl (Telaglenastat) in Patients With Advanced NSCLC (NCI 10327): Rationale and Study Design. Clin Lung Cancer. 2021 01; 22(1):67-70. Riess JW, Frankel P, Shackelford D, Dunphy M, Badawi RD, Nardo L, Cherry SR, Lanza I, Reid J, Gonsalves WI, Kunos C, Gandara DR, Lara PN, Newman E, Paik PK. PMID: 33229301; PMCID: PMC7834952.
      View in: PubMed   Mentions: 5     Fields:    
    12. Reply to: In vivo quantification of mitochondrial membrane potential. Nature. 2020 07; 583(7815):E19-E20. Momcilovic M, Shirihai O, Murphy MP, Koehler CM, Sadeghi S, Shackelford DB. PMID: 32641810.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    13. Quantification of cristae architecture reveals time-dependent characteristics of individual mitochondria. Life Sci Alliance. 2020 07; 3(7). Segawa M, Wolf DM, Hultgren NW, Williams DS, van der Bliek AM, Shackelford DB, Liesa M, Shirihai OS. PMID: 32499316; PMCID: PMC7283135.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    14. Publisher Correction: In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer. Nature. 2020 01; 577(7791):E7. Momcilovic M, Jones A, Bailey ST, Waldmann CM, Li R, Lee JT, Abdelhady G, Gomez A, Holloway T, Schmid E, Stout D, Fishbein MC, Stiles L, Dabir DV, Dubinett SM, Christofk H, Shirihai O, Koehler CM, Sadeghi S, Shackelford DB. PMID: 31896820.
      View in: PubMed   Mentions:    Fields:    
    15. In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer. Nature. 2019 11; 575(7782):380-384. Momcilovic M, Jones A, Bailey ST, Waldmann CM, Li R, Lee JT, Abdelhady G, Gomez A, Holloway T, Schmid E, Stout D, Fishbein MC, Stiles L, Dabir DV, Dubinett SM, Christofk H, Shirihai O, Koehler CM, Sadeghi S, Shackelford DB. PMID: 31666695; PMCID: PMC7328016.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    16. Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent. EMBO J. 2019 11 15; 38(22):e101056. Wolf DM, Segawa M, Kondadi AK, Anand R, Bailey ST, Reichert AS, van der Bliek AM, Shackelford DB, Liesa M, Shirihai OS. PMID: 31609012; PMCID: PMC6856616.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    17. p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas. Cell Rep. 2019 08 13; 28(7):1860-1878.e9. Hsieh MH, Choe JH, Gadhvi J, Kim YJ, Arguez MA, Palmer M, Gerold H, Nowak C, Do H, Mazambani S, Knighton JK, Cha M, Goodwin J, Kang MK, Jeong JY, Lee SY, Faubert B, Xuan Z, Abel ED, Scafoglio C, Shackelford DB, Minna JD, Singh PK, Shulaev V, Bleris L, Hoyt K, Kim J, Inoue M, DeBerardinis RJ, Kim TH, Kim JW. PMID: 31412252; PMCID: PMC7048935.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    18. Teaching an Old Drug New Tricks. Cancer Cell. 2019 05 13; 35(5):709-711. Momcilovic M, Shackelford DB. PMID: 31085172.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. Bioluminescent-based imaging and quantification of glucose uptake in vivo. Nat Methods. 2019 06; 16(6):526-532. Maric T, Mikhaylov G, Khodakivskyi P, Bazhin A, Sinisi R, Bonhoure N, Yevtodiyenko A, Jones A, Muhunthan V, Abdelhady G, Shackelford D, Goun E. PMID: 31086341; PMCID: PMC6546603.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    20. Sodium-glucose transporter 2 is a diagnostic and therapeutic target for early-stage lung adenocarcinoma. Sci Transl Med. 2018 11 14; 10(467). Scafoglio CR, Villegas B, Abdelhady G, Bailey ST, Liu J, Shirali AS, Wallace WD, Magyar CE, Grogan TR, Elashoff D, Walser T, Yanagawa J, Aberle DR, Barrio JR, Dubinett SM, Shackelford DB. PMID: 30429355; PMCID: PMC6428683.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimals
    21. Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models. Cell Metab. 2019 02 05; 29(2):285-302.e7. Eichner LJ, Brun SN, Herzig S, Young NP, Curtis SD, Shackelford DB, Shokhirev MN, Leblanc M, Vera LI, Hutchins A, Ross DS, Shaw RJ, Svensson RU. PMID: 30415923; PMCID: PMC6365213.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    22. Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization. Cell. 2018 09 20; 175(1):117-132.e21. Sullivan WJ, Mullen PJ, Schmid EW, Flores A, Momcilovic M, Sharpley MS, Jelinek D, Whiteley AE, Maxwell MB, Wilde BR, Banerjee U, Coller HA, Shackelford DB, Braas D, Ayer DE, de Aguiar Vallim TQ, Lowry WE, Christofk HR. PMID: 30197082; PMCID: PMC6151140.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    23. Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer. J Vis Exp. 2018 07 21; (137). Momcilovic M, Bailey ST, Lee JT, Zamilpa C, Jones A, Abdelhady G, Mansfield J, Francis KP, Shackelford DB. PMID: 30080208; PMCID: PMC6126521.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    24. The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma. Cancer Cell. 2018 05 14; 33(5):905-921.e5. Momcilovic M, Bailey ST, Lee JT, Fishbein MC, Braas D, Go J, Graeber TG, Parlati F, Demo S, Li R, Walser TC, Gricowski M, Shuman R, Ibarra J, Fridman D, Phelps ME, Badran K, St John M, Bernthal NM, Federman N, Yanagawa J, Dubinett SM, Sadeghi S, Christofk HR, Shackelford DB. PMID: 29763624; PMCID: PMC6451645.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    25. An Automated Multidose Synthesis of the Potentiometric PET Probe 4-[18F]Fluorobenzyl-Triphenylphosphonium ([18F]FBnTP). Mol Imaging Biol. 2018 04; 20(2):205-212. Waldmann CM, Gomez A, Marchis P, Bailey ST, Momcilovic M, Jones AE, Shackelford DB, Sadeghi S. PMID: 28905308; PMCID: PMC6054454.
      View in: PubMed   Mentions: 5     Fields:    
    26. Targeting Hypoxia-Inducible Factor-1α/Pyruvate Dehydrogenase Kinase 1 Axis by Dichloroacetate Suppresses Bleomycin-induced Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2018 02; 58(2):216-231. Goodwin J, Choi H, Hsieh MH, Neugent ML, Ahn JM, Hayenga HN, Singh PK, Shackelford DB, Lee IK, Shulaev V, Dhar S, Takeda N, Kim JW. PMID: 28915065; PMCID: PMC5805994.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    27. Imaging Cancer Metabolism. Biomol Ther (Seoul). 2018 Jan 01; 26(1):81-92. Momcilovic M, Shackelford DB. PMID: 29212309; PMCID: PMC5746040.
      View in: PubMed   Mentions: 9  
    28. The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition. Nat Commun. 2017 05 26; 8:15503. Goodwin J, Neugent ML, Lee SY, Choe JH, Choi H, Jenkins DMR, Ruthenborg RJ, Robinson MW, Jeong JY, Wake M, Abe H, Takeda N, Endo H, Inoue M, Xuan Z, Yoo H, Chen M, Ahn JM, Minna JD, Helke KL, Singh PK, Shackelford DB, Kim JW. PMID: 28548087; PMCID: PMC5458561.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    29. Dual targeting of EGFR and glutaminase in lung cancer. Mol Cell Oncol. 2018; 5(3):e1297883. Momcilovic M, Shackelford DB. PMID: 30250881; PMCID: PMC6150022.
      View in: PubMed   Mentions:
    30. Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer. Cell Rep. 2017 01 17; 18(3):601-610. Momcilovic M, Bailey ST, Lee JT, Fishbein MC, Magyar C, Braas D, Graeber T, Jackson NJ, Czernin J, Emberley E, Gross M, Janes J, Mackinnon A, Pan A, Rodriguez M, Works M, Zhang W, Parlati F, Demo S, Garon E, Krysan K, Walser TC, Dubinett SM, Sadeghi S, Christofk HR, Shackelford DB. PMID: 28099841; PMCID: PMC5260616.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    31. Repurposing phenformin for the targeting of glioma stem cells and the treatment of glioblastoma. Oncotarget. 2016 Aug 30; 7(35):56456-56470. Jiang W, Finniss S, Cazacu S, Xiang C, Brodie Z, Mikkelsen T, Poisson L, Shackelford DB, Brodie C. PMID: 27486821; PMCID: PMC5302927.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    32. Heightening Energetic Stress Selectively Targets LKB1-Deficient Non-Small Cell Lung Cancers. Cancer Res. 2015 Nov 15; 75(22):4910-22. Momcilovic M, McMickle R, Abt E, Seki A, Simko SA, Magyar C, Stout DB, Fishbein MC, Walser TC, Dubinett SM, Shackelford DB. PMID: 26574479; PMCID: PMC4654699.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    33. Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α. Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7):2554-9. Faubert B, Vincent EE, Griss T, Samborska B, Izreig S, Svensson RU, Mamer OA, Avizonis D, Shackelford DB, Shaw RJ, Jones RG. PMID: 24550282; PMCID: PMC3932920.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    34. The mTOR kinase inhibitors, CC214-1 and CC214-2, preferentially block the growth of EGFRvIII-activated glioblastomas. Clin Cancer Res. 2013 Oct 15; 19(20):5722-32. Gini B, Zanca C, Guo D, Matsutani T, Masui K, Ikegami S, Yang H, Nathanson D, Villa GR, Shackelford D, Zhu S, Tanaka K, Babic I, Akhavan D, Lin K, Assuncao A, Gu Y, Bonetti B, Mortensen DS, Xu S, Raymon HK, Cavenee WK, Furnari FB, James CD, Kroemer G, Heath JR, Hege K, Chopra R, Cloughesy TF, Mischel PS. PMID: 24030701; PMCID: PMC3815450.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    35. Unravelling the connection between metabolism and tumorigenesis through studies of the liver kinase B1 tumour suppressor. J Carcinog. 2013 Aug 08; 12:16. Shackelford DB. PMID: 24082825; PMCID: PMC3779404.
      View in: PubMed   Mentions: 13  
    36. Hypoxia induces a phase transition within a kinase signaling network in cancer cells. Proc Natl Acad Sci U S A. 2013 Apr 09; 110(15):E1352-60. Wei W, Shi Q, Remacle F, Qin L, Shackelford DB, Shin YS, Mischel PS, Levine RD, Heath JR. PMID: 23530221; PMCID: PMC3625329.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    37. LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin. Cancer Cell. 2013 Feb 11; 23(2):143-58. Shackelford DB, Abt E, Gerken L, Vasquez DS, Seki A, Leblanc M, Wei L, Fishbein MC, Czernin J, Mischel PS, Shaw RJ. PMID: 23352126; PMCID: PMC3579627.
      View in: PubMed   Mentions: 244     Fields:    Translation:HumansAnimalsCells
    38. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science. 2011 Jan 28; 331(6016):456-61. Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W, Vasquez DS, Joshi A, Gwinn DM, Taylor R, Asara JM, Fitzpatrick J, Dillin A, Viollet B, Kundu M, Hansen M, Shaw RJ. PMID: 21205641; PMCID: PMC3030664.
      View in: PubMed   Mentions: 975     Fields:    Translation:HumansAnimalsCells
    39. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat Rev Cancer. 2009 08; 9(8):563-75. Shackelford DB, Shaw RJ. PMID: 19629071; PMCID: PMC2756045.
      View in: PubMed   Mentions: 689     Fields:    Translation:HumansAnimalsCells
    40. mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome. Proc Natl Acad Sci U S A. 2009 Jul 07; 106(27):11137-42. Shackelford DB, Vasquez DS, Corbeil J, Wu S, Leblanc M, Wu CL, Vera DR, Shaw RJ. PMID: 19541609; PMCID: PMC2708689.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimalsCells
    41. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell. 2008 Apr 25; 30(2):214-26. Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE, Shaw RJ. PMID: 18439900; PMCID: PMC2674027.
      View in: PubMed   Mentions: 1460     Fields:    Translation:HumansAnimalsCells
    42. Targeted degradation of the AML1/MDS1/EVI1 oncoprotein by arsenic trioxide. Cancer Res. 2006 Dec 01; 66(23):11360-9. Shackelford D, Kenific C, Blusztajn A, Waxman S, Ren R. PMID: 17145882.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
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