Noah Carvajal Federman

Title(s)HS Clinical Professor, Pediatrics
SchoolMedicine
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    Other Positions
    Title(s)HS Clinical Professor, Orthopaedic Surgery


    Collapse Biography 
    Collapse Education and Training
    Williams College, Williamstown, MAB.A.1997English and Neuroscience
    Mount Sinai School of Medicine, New York, NYM.D.2002
    UCLA Mattel Children's Hospital, Los Angeles, CAResidency2005Pediatrics
    UCLA Mattel Children's Hospital, Los Angeles, CAFellowship2008Pediatric Hematology/Oncology
    Collapse Awards and Honors
    American Society of Hematology2000Medical Student Research Award
    UCLA Science Day2008Fellow Research Award
    UCLA2009STAR Award for excellence and compassion in patient care
    2011Reardon Endowed Chair in Pediatric Hematology/Oncology
    2013Leonard Tow Humanism in Medicine Award for compassion and sensitivity in the delivery of care
    UCLA Division of Pediatric Hematology/Oncology2014Fellowship Teaching Award for excellence in teaching
    BestDoctors.com2014Voted Best Doctors
    SuperDoctors.com2015Voted Southern California Rising Star
    David Geffen School of Medicine at UCLA 2016Sherman Mellinkoff Faculty Award for the finest in doctor-patient relationships & medical education

    Collapse Overview 
    Collapse Overview
    Dr. Noah Federman is the Director of the Pediatric Bone and Soft Tissue Sarcoma Program at UCLA, part of the UCLA Sarcoma Program and UCLA's Jonsson Comprehensive Cancer Center. Dr. Federman specializes in treating children, adolescents and young adults with these aggressive cancers. He runs an incredibly comprehensive and & multidisciplinary program involving pediatric and medical oncologists, radiation oncologists, orthopedic oncology surgeons, musculoskeletal radiologists and pathologists, nuclear medicine specialists, physical therapists and prosthetic specialists. Dr. Federman also specializes in conducting clinical trials and leads an experienced clinical research team devoted to providing access to clinical trials for children with refractory, recurrent and metastatic bone and soft tissue cancers.

    Dr. Federman is currently the Medical Director of the UCLA Clinical and Translational Research Center overseeing close to three hundred clinical trials. In addition, he serves as Vice-Chair of the Clinical and Translational Science Institute’s (CTSI) Scientific Rationale Committee and is Chair of the CTSI Data Safety Monitoring Board. In these roles, he ensures that clinical research is of the highest quality and being performed with utmost safety at UCLA. He is also the Medical Director of the UCLA CTSI’s Research Associates Program (RAP) which provides undergraduate UCLA students with the opportunity to gain exposure to hospital-based medicine as well as clinical research in an academic setting.

    Collapse Research 
    Collapse Research Activities and Funding
    A Phase 1, Dose Escalation Study of Intravenous TK216 in Patients with Relapsed or Refractory Ewing Sarcoma
    Oncternal Therapeutics, Inc. TK 216-01Jul 16, 2019 - Jul 15, 2023
    Role: Principal Investigator
    A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial of Nirogacestat Versus Placebo in Adult Patients with Progressing Desmoid Tumors/Aggressive Fibromatosis (DT/AF)
    Springworks Therapeutics, LLC NIR-DT-301Mar 25, 2019 - Mar 25, 2023
    Role: Principal Investigator
    An Open-Label Phase 1B Study of the Safety, Tolerability, and Preliminary Antitumor Activity of INCB059872 and INCB057643 in Participants With Relapsed or Refractory Ewing SarcomaexpiresN
    Incyte Corporation INCB 59872-103Nov 8, 2018 - Nov 8, 2021
    Role: Principal Investigator
    A Phase 1/2 Study of the TRK Inhibitor LOXO-195 in Adult and Pediatric Subjects with Previously Treated NTRK Fusion Cancers
    Loxo Oncology, Inc. LOXO EXT-1005Jun 1, 2018 - May 31, 2023
    Role: Principal Investigator
    UCLA Clinical Translational Science Institute
    NIH UL1TR001881Jul 1, 2016 - May 31, 2022
    Role: Medical Director, Clinical and Translational Research Center

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Featured Content 
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Orbital indeterminate cell histiocytosis. Orbit. 2024 Feb 19; 1-5. Oh AJ, Sears CM, Vadivelan AA, Gomperts BN, Federman N, Said J, Roelofs KA. PMID: 38374584.
      View in: PubMed   Mentions:
    2. Sarcoma in patients with Lynch syndrome and response to immunotherapy. J Surg Oncol. 2023 Dec 27. Shehata MS, Lofftus SY, Park JY, Singh AS, Federman NC, Eilber FC, Crompton JG, McCaw TR. PMID: 38151827.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. From Mendel to Gene Therapy. Anticancer Res. 2023 10; 43(10):4257-4261. Jeffrey SL, Brigham DA, Chawla SP, Federman N, Hall FL, Gordon EM. PMID: 37772566.
      View in: PubMed   Mentions:    Fields:    
    4. Exploring Barriers to Pediatric Cancer Clinical Trials: The Role of a Networked, Just-in-Time Study Program. Clin Ther. 2023 Nov; 45(11):1148-1150. Rivers Z, Hyde B, Ronski K, Stearns D, Toll S, Ritt K, Cooney M, Nimeiri H, Federman N, Kaneva K. PMID: 37783645.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. A review of the therapeutic potential of histone deacetylase inhibitors in rhabdomyosarcoma. Front Oncol. 2023; 13:1244035. Selim O, Song C, Kumar A, Phelan R, Singh A, Federman N. PMID: 37664028; PMCID: PMC10471891.
      View in: PubMed   Mentions: 1  
    6. The landscape of drug sensitivity and resistance in sarcoma. bioRxiv. 2023 Aug 08. Al Shihabi A, Tebon PJ, Nguyen HTL, Chantharasamee J, Sartini S, Davarifar A, Jensen AY, Diaz-Infante M, Cox H, Gonzalez AE, Swearingen S, Tavanaie N, Dry S, Singh A, Chmielowski B, Crompton JG, Kalbasi A, Eilber FC, Hornicek F, Bernthal N, Nelson SD, Boutros PC, Federman N, Yanagawa J, Soragni A. PMID: 37292676; PMCID: PMC10245988.
      View in: PubMed   Mentions:
    7. Adolescent and Young Adult (AYA) Oncology, Version 2.2024, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2023 08; 21(8):851-880. Bhatia S, Pappo AS, Acquazzino M, Allen-Rhoades WA, Barnett M, Borinstein SC, Casey R, Choo S, Chugh R, Dinner S, Ermoian R, Fair D, Federman N, Folbrecht J, Gandhi S, Germann J, Goldsby R, Hayashi R, Huang AY, Huang MS, Jacobs LA, Lee-Miller C, Link MP, Livingston JA, Lustberg M, Malogolowkin M, Oeffinger KC, Pratilas CA, Reed D, Skiles J, von Mehren M, Yeager N, Montgomery S, Hang L. PMID: 37549914.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    8. Fibroblast Activation Protein Expression in Sarcomas. Sarcoma. 2023; 2023:2480493. Crane JN, Graham DS, Mona CE, Nelson SD, Samiei A, Dawson DW, Dry SM, Masri MG, Crompton JG, Benz MR, Czernin J, Eilber FC, Graeber TG, Calais J, Federman NC. PMID: 37333052; PMCID: PMC10275689.
      View in: PubMed   Mentions:
    9. A pilot study evaluating the use of sirolimus in children and young adults with desmoid-type fibromatosis. Pediatr Blood Cancer. 2023 Jun 07; e30466. Weiss AR, Dry S, Maygar C, Cutler A, Lary CW, Khoo C, Fergione JE, Hounchell MM, Glick K, Browning M, Choo SH, Hawkins DS, Lagmay J, Manalang M, Skapek SX, Weigel B, Verwys S, Federman N. PMID: 37283290.
      View in: PubMed   Mentions: 1     Fields:    
    10. Successful treatment of severe immune checkpoint inhibitor associated autoimmune hepatitis with basiliximab: a case report. Front Immunol. 2023; 14:1156746. Zarrabi M, Hamilton C, French SW, Federman N, Nowicki TS. PMID: 37325672; PMCID: PMC10262312.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Maternal migraine and risk of pediatric cancers. Pediatr Blood Cancer. 2023 07; 70(7):e30385. Orimoloye HT, Heck JE, Charles A, Saechao C, He D, Federman N, Olsen J, Ritz B, Hansen J. PMID: 37101365; PMCID: PMC10278537.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    12. Pediatric Rectal Adenocarcinoma With Mismatch Repair Deficiency Responds to Immunotherapy. JCO Precis Oncol. 2023 04; 7:e2200378. Qureshi N, Hoffman TL, Kaneva K, Zomorrodian S, Scapa JV, Hitchins MP, Federman N. PMID: 37053536; PMCID: PMC10309547.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Nirogacestat, a γ-Secretase Inhibitor for Desmoid Tumors. N Engl J Med. 2023 Mar 09; 388(10):898-912. Gounder M, Ratan R, Alcindor T, Schöffski P, van der Graaf WT, Wilky BA, Riedel RF, Lim A, Smith LM, Moody S, Attia S, Chawla S, D'Amato G, Federman N, Merriam P, Van Tine BA, Vincenzi B, Benson C, Bui NQ, Chugh R, Tinoco G, Charlson J, Dileo P, Hartner L, Lapeire L, Mazzeo F, Palmerini E, Reichardt P, Stacchiotti S, Bailey HH, Burgess MA, Cote GM, Davis LE, Deshpande H, Gelderblom H, Grignani G, Loggers E, Philip T, Pressey JG, Kummar S, Kasper B. PMID: 36884323.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCTClinical Trials
    14. SAINT: A Phase I/Expanded Phase II Study Using Safe Amounts of Ipilimumab, Nivolumab and Trabectedin as First-Line Treatment of Advanced Soft Tissue Sarcoma. Cancers (Basel). 2023 Jan 31; 15(3). Gordon EM, Chawla SP, Tellez WA, Younesi E, Thomas S, Chua-Alcala VS, Chomoyan H, Valencia C, Brigham DA, Moradkhani A, Quon D, Srikureja A, Wong SG, Tseng W, Federman N. PMID: 36765863; PMCID: PMC9913367.
      View in: PubMed   Mentions: 6  
    15. Maternal anemia and the risk of childhood cancer: A population-based cohort study in Taiwan. Pediatr Blood Cancer. 2023 03; 70(3):e30188. Orimoloye HT, Qureshi N, Lee PC, Wu CK, Saechao C, Federman N, Li CY, Ritz B, Arah OA, Heck JE. PMID: 36600459; PMCID: PMC10773261.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Maternal anemia and childhood cancer: a population-based case-control study in Denmark. Cancer Epidemiol. 2023 02; 82:102308. Qureshi N, Orimoloye H, Hansen J, Saechao C, Olsen J, Federman N, Huang X, He D, Ritz B, Heck JE. PMID: 36434977; PMCID: PMC9904448.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    17. REsCue trial: Randomized controlled clinical trial with extended-release calcifediol in symptomatic COVID-19 outpatients. Nutrition. 2023 03; 107:111899. Bishop CW, Ashfaq A, Melnick JZ, Vazquez-Escarpanter E, Fialkow JA, Strugnell SA, Choe J, Kalantar-Zadeh K, Federman NC, Ng D, Adams JS. PMID: 36529089; PMCID: PMC9639413.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    18. Maternal diabetes and childhood cancer risks in offspring: two population-based studies. Br J Cancer. 2022 11; 127(10):1837-1842. Huang X, Hansen J, Lee PC, Wu CK, Federman N, Arah OA, Li CY, Olsen J, Ritz B, Heck JE. PMID: 36088507; PMCID: PMC9643384.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    19. Molecular pathogenesis of desmoid tumor and the role of γ-secretase inhibition. NPJ Precis Oncol. 2022 Sep 06; 6(1):62. Federman N. PMID: 36068332; PMCID: PMC9448813.
      View in: PubMed   Mentions: 7  
    20. IgM Warm Autoantibodies Causing Autoimmune Hemolytic Anemia in a Pediatric Patient. Lab Med. 2022 Jul 04; 53(4):e83-e86. Fortes P, Baez J, McGonigle AM, Ziman A, Federman N, Ward DC. PMID: 34865065.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    21. Cohort study of familial viral hepatitis and risks of paediatric cancers. Int J Epidemiol. 2022 05 09; 51(2):448-457. Heck JE, Wu CK, Huang X, Chew KW, Tong M, Federman N, Ritz B, Arah OA, Li CY, Yu F, Olsen J, Hansen J, Lee PC. PMID: 34966942; PMCID: PMC9308392.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    22. Polyendocrine Autoimmunity and Diabetic Ketoacidosis Following Anti-PD-1 and Interferon α. Pediatrics. 2022 04 01; 149(4). Dasgupta A, Tsay E, Federman N, Lechner MG, Su MA. PMID: 35274131; PMCID: PMC9804498.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    23. Coupling Lipid Labeling and Click Chemistry Enables Isolation of Extracellular Vesicles for Noninvasive Detection of Oncogenic Gene Alterations. Adv Sci (Weinh). 2022 05; 9(14):e2105853. Sun N, Tran BV, Peng Z, Wang J, Zhang C, Yang P, Zhang TX, Widjaja J, Zhang RY, Xia W, Keir A, She JW, Yu HH, Shyue JJ, Zhu H, Agopian VG, Pei R, Tomlinson JS, Toretsky JA, Jonas SJ, Federman N, Lu S, Tseng HR, Zhu Y. PMID: 35486030; PMCID: PMC9108594.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    24. Personalized chordoma organoids for drug discovery studies. Sci Adv. 2022 02 18; 8(7):eabl3674. Al Shihabi A, Davarifar A, Nguyen HTL, Tavanaie N, Nelson SD, Yanagawa J, Federman N, Bernthal N, Hornicek F, Soragni A. PMID: 35171675; PMCID: PMC8849332.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    25. Diagnosis and management of TRK fusion cancer. Am J Manag Care. 2022 01; 28(2 Suppl):S15-S25. Kummar S, Italiano A, Brose MS, Carlson JJ, Sullivan SD, Lassen U, Federman N. PMID: 35201680.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. Comparative effectiveness of larotrectinib and entrectinib for TRK fusion cancer. Am J Manag Care. 2022 01; 28(2 Suppl):S26-S32. Carlson JJ, Italiano A, Brose MS, Federman N, Lassen U, Kummar S, Sullivan SD. PMID: 35201681.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    27. T-LAK cell-originated protein kinase (TOPK): an emerging prognostic biomarker and therapeutic target in osteosarcoma. Mol Oncol. 2021 12; 15(12):3721-3737. Thanindratarn P, Wei R, Dean DC, Singh A, Federman N, Nelson SD, Hornicek FJ, Duan Z. PMID: 34115928; PMCID: PMC8637563.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    28. The Role of Social Media in Providing Support from Friends for Adolescent and Young Adult (AYA) Patients and Survivors of Sarcoma: Perspectives of AYA, Parents, and Providers. J Adolesc Young Adult Oncol. 2021 12; 10(6):720-725. Donovan E, Martin SR, Seidman LC, Zeltzer LK, Cousineau TM, Payne LA, Knoll M, Weiman M, Federman NC. PMID: 33844938; PMCID: PMC8742252.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    29. What's New in Pediatric Orthopaedic Tumor Surgery. J Pediatr Orthop. 2021 Feb 01; 41(2):e174-e180. Williams AK, Crawford B, Federman NC, Bernthal N, Arkader A. PMID: 33027233.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    30. Primary Renal Ewing Sarcoma in Children and Young Adults. J Pediatr Hematol Oncol. 2020 11; 42(8):474-481. Bradford K, Nobori A, Johnson B, Allen-Rhoades W, Naik-Mathuria B, Panosyan EH, Gotesman M, Lasky J, Cheng J, Ikeda A, Goldstein J, Singh A, Federman N. PMID: 32282650; PMCID: PMC7554078.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    31. [18F]FDG PET/CT for evaluating early response to neoadjuvant chemotherapy in pediatric patients with sarcoma: a prospective single-center trial. EJNMMI Res. 2020 Oct 15; 10(1):122. Polverari G, Ceci F, Passera R, Crane J, Du L, Li G, Fanti S, Bernthal N, Eilber FC, Allen-Auerbach M, Czernin J, Calais J, Federman N. PMID: 33063147; PMCID: PMC7561652.
      View in: PubMed   Mentions: 1  
    32. Coupling Nanostructured Microchips with Covalent Chemistry Enables Purification of Sarcoma-Derived Extracellular Vesicles for Downstream Functional Studies. Adv Funct Mater. 2020 Dec 01; 30(49). Dong J, Zhang RY, Sun N, Hu J, Smalley MD, Zhou A, Yue H, Rothermich W, Chen M, Chen J, Ye J, Teng PC, Qi D, Toretsky JA, Tomlinson JS, Li M, Weiss PS, Jonas SJ, Federman N, Wu L, Zhao M, Tseng HR, Zhu Y. PMID: 34220409; PMCID: PMC8248519.
      View in: PubMed   Mentions: 12  
    33. Spina bifida and pediatric cancers. Pediatr Hematol Oncol. 2020 Oct; 37(7):630-636. Heck JE, Lee PC, Wu CK, Li CY, He D, Federman N, Yu F, Olsen J, Ritz B, Arah OA, Hansen J. PMID: 32364426; PMCID: PMC7577564.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    34. Results of a Randomized, Double-Blinded, Placebo-Controlled, Phase 2.5 Study of Saracatinib (AZD0530), in Patients with Recurrent Osteosarcoma Localized to the Lung. Sarcoma. 2020; 2020:7935475. Baird K, Glod J, Steinberg SM, Reinke D, Pressey JG, Mascarenhas L, Federman N, Marina N, Chawla S, Lagmay JP, Goldberg J, Milhem M, Loeb DM, Butrynski JE, Turpin B, Staddon A, Spunt SL, Jones RL, Rodler ET, Schuetze SM, Okuno SH, Helman L. PMID: 32398945; PMCID: PMC7211262.
      View in: PubMed   Mentions: 15  
    35. Larotrectinib in patients with TRK fusion-positive solid tumours: a pooled analysis of three phase 1/2 clinical trials. Lancet Oncol. 2020 04; 21(4):531-540. Hong DS, DuBois SG, Kummar S, Farago AF, Albert CM, Rohrberg KS, van Tilburg CM, Nagasubramanian R, Berlin JD, Federman N, Mascarenhas L, Geoerger B, Dowlati A, Pappo AS, Bielack S, Doz F, McDermott R, Patel JD, Schilder RJ, Tahara M, Pfister SM, Witt O, Ladanyi M, Rudzinski ER, Nanda S, Childs BH, Laetsch TW, Hyman DM, Drilon A. PMID: 32105622; PMCID: PMC7497841.
      View in: PubMed   Mentions: 292     Fields:    Translation:HumansCTClinical Trials
    36. A Case of a 15-Month-Old With Periorbital Edema and Severe Anemia. Pediatrics. 2020 03; 145(3). Kamzan AD, Newcomer CA, Wozniak LJ, Federman NC, Kim LS. PMID: 32079720.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    37. Clinical and molecular characterization of primary sclerosing epithelioid fibrosarcoma of bone and review of the literature. Genes Chromosomes Cancer. 2020 04; 59(4):217-224. Tsuda Y, Dickson BC, Dry SM, Federman N, Suurmeijer AJH, Swanson D, Sung YS, Zhang L, Healey JH, Antonescu CR. PMID: 31675134; PMCID: PMC7082133.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    38. A Phase 2, International, Multicenter, Open-label Clinical Trial of Subcutaneous Tbo-Filgrastim in Pediatric Patients With Solid Tumors Undergoing Myelosuppressive Chemotherapy. J Pediatr Hematol Oncol. 2019 10; 41(7):525-531. Federman N, Dragomir MD, Kizyma Z, Roganovic J, Bias P, Lammerich A, Ben Arie ZR, Zou L, Hoehn G, Buchner A. PMID: 31274668.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    39. Larotrectinib, a highly selective tropomyosin receptor kinase (TRK) inhibitor for the treatment of TRK fusion cancer. Expert Rev Clin Pharmacol. 2019 Oct; 12(10):931-939. Federman N, McDermott R. PMID: 31469968.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    40. Use of Denosumab in Children With Osteoclast Bone Dysplasias: Report of Three Cases. JBMR Plus. 2019 Oct; 3(10):e10210. Upfill-Brown A, Bukata S, Bernthal NM, Felsenfeld AL, Nelson SD, Singh A, Wesseling-Perry K, Eilber FC, Federman NC. PMID: 31687646; PMCID: PMC6820455.
      View in: PubMed   Mentions: 10  
    41. Is polycystic kidney disease associated with malignancy in children? Mol Genet Genomic Med. 2019 07; 7(7):e00725. Friend BD, Wolfe Schneider K, Garrington T, Truscott L, Martinez-Agosto JA, Venick RS, Tsai Chambers E, Weng P, Farmer DG, Chang VY, Federman N. PMID: 31197971; PMCID: PMC6625336.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    42. Pathologic Response to Neoadjuvant Therapy is Associated With Improved Long-term Survival in High-risk Primary Localized Malignant Peripheral Nerve Sheath Tumors. Am J Clin Oncol. 2019 05; 42(5):426-431. Shurell-Linehan E, DiPardo BJ, Elliott IA, Graham DS, Eckardt MA, Dry SM, Nelson SD, Singh AS, Kalbasi A, Federman N, Bernthal NM, Eilber FC. PMID: 30913092.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    43. A Mobile-Based Mindfulness and Social Support Program for Adolescents and Young Adults With Sarcoma: Development and Pilot Testing. JMIR Mhealth Uhealth. 2019 03 18; 7(3):e10921. Donovan E, Martin SR, Seidman LC, Zeltzer LK, Cousineau TM, Payne LA, Trant M, Weiman M, Knoll M, Federman NC. PMID: 30882352; PMCID: PMC6441858.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    44. TRK Fusion Cancers in Children: A Clinical Review and Recommendations for Screening. J Clin Oncol. 2019 02 20; 37(6):513-524. Albert CM, Davis JL, Federman N, Casanova M, Laetsch TW. PMID: 30592640.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    45. Long-term Outcomes With Ifosfamide-based Hypofractionated Preoperative Chemoradiotherapy for Extremity Soft Tissue Sarcomas. Am J Clin Oncol. 2018 12; 41(12):1154-1161. Pennington JD, Eilber FC, Eilber FR, Singh AS, Reed JP, Chmielowski B, Eckardt JJ, Bukata SV, Bernthal NM, Federman N, Nelson SD, Dry SM, Wang PC, Luu M, Selch MT, Steinberg ML, Kalbasi A, Kamrava M. PMID: 29664796.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    46. Fetal programming and Wilms tumor. Pediatr Blood Cancer. 2019 01; 66(1):e27461. Heck JE, He D, Janzen C, Federman N, Olsen J, Ritz B, Hansen J. PMID: 30255546; PMCID: PMC6530460.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    47. The use of neoadjuvant larotrectinib in the management of children with locally advanced TRK fusion sarcomas. Cancer. 2018 11 01; 124(21):4241-4247. DuBois SG, Laetsch TW, Federman N, Turpin BK, Albert CM, Nagasubramanian R, Anderson ME, Davis JL, Qamoos HE, Reynolds ME, Cruickshank S, Cox MC, Hawkins DS, Mascarenhas L, Pappo AS. PMID: 30204247; PMCID: PMC6263791.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCTClinical Trials
    48. The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma. Cancer Cell. 2018 05 14; 33(5):905-921.e5. Momcilovic M, Bailey ST, Lee JT, Fishbein MC, Braas D, Go J, Graeber TG, Parlati F, Demo S, Li R, Walser TC, Gricowski M, Shuman R, Ibarra J, Fridman D, Phelps ME, Badran K, St John M, Bernthal NM, Federman N, Yanagawa J, Dubinett SM, Sadeghi S, Christofk HR, Shackelford DB. PMID: 29763624; PMCID: PMC6451645.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    49. Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1/2 study. Lancet Oncol. 2018 05; 19(5):705-714. Laetsch TW, DuBois SG, Mascarenhas L, Turpin B, Federman N, Albert CM, Nagasubramanian R, Davis JL, Rudzinski E, Feraco AM, Tuch BB, Ebata KT, Reynolds M, Smith S, Cruickshank S, Cox MC, Pappo AS, Hawkins DS. PMID: 29606586; PMCID: PMC5949072.
      View in: PubMed   Mentions: 193     Fields:    Translation:HumansCTClinical Trials
    50. Is Core Needle Biopsy Reliable in Differentiating Between Aggressive Benign and Malignant Radiolucent Bone Tumors? Clin Orthop Relat Res. 2018 03; 476(3):568-577. Hegde V, Burke ZDC, Park HY, Zoller SD, Johansen D, Kelley BV, Levine B, Motamedi K, Federman NC, Seeger LL, Nelson SD, Bernthal NM. PMID: 29529643; PMCID: PMC6260019.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    51. Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children. N Engl J Med. 2018 02 22; 378(8):731-739. Drilon A, Laetsch TW, Kummar S, DuBois SG, Lassen UN, Demetri GD, Nathenson M, Doebele RC, Farago AF, Pappo AS, Turpin B, Dowlati A, Brose MS, Mascarenhas L, Federman N, Berlin J, El-Deiry WS, Baik C, Deeken J, Boni V, Nagasubramanian R, Taylor M, Rudzinski ER, Meric-Bernstam F, Sohal DPS, Ma PC, Raez LE, Hechtman JF, Benayed R, Ladanyi M, Tuch BB, Ebata K, Cruickshank S, Ku NC, Cox MC, Hawkins DS, Hong DS, Hyman DM. PMID: 29466156; PMCID: PMC5857389.
      View in: PubMed   Mentions: 883     Fields:    Translation:HumansCTClinical Trials
    52. Alveolar soft part sarcoma in children and young adults: A report of 69 cases. Pediatr Blood Cancer. 2018 05; 65(5):e26953. Flores RJ, Harrison DJ, Federman NC, Furman WL, Huh WW, Broaddus EG, Okcu MF, Venkatramani R. PMID: 29350467.
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    53. Clinical Factors That Affect the Establishment of Soft Tissue Sarcoma Patient-Derived Orthotopic Xenografts: A University of California, Los Angeles, Sarcoma Program Prospective Clinical Trial. JCO Precis Oncol. 2017; 2017. Russell TA, Eckardt MA, Murakami T, Elliott IA, Kawaguchi K, Kiyuna T, Igarashi K, Li Y, Crompton JG, Graham DS, Dry SM, Bernthal N, Yanagawa J, Kalbasi A, Federman N, Chmielowski B, Singh AS, Hoffman RM, Eilber FC. PMID: 30613825; PMCID: PMC6319895.
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    54. Fatal orthotopic liver transplant organ rejection induced by a checkpoint inhibitor in two patients with refractory, metastatic hepatocellular carcinoma. Pediatr Blood Cancer. 2017 Dec; 64(12). Friend BD, Venick RS, McDiarmid SV, Zhou X, Naini B, Wang H, Farmer DG, Busuttil RW, Federman N. PMID: 28643391.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    55. Rexin-G®, a tumor-targeted retrovector for malignant peripheral nerve sheath tumor: A case report. Mol Clin Oncol. 2017 Jun; 6(6):861-865. Kim S, Federman N, Gordon EM, Hall FL, Chawla SP. PMID: 28588778; PMCID: PMC5451875.
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    56. Tumor-targeting Salmonella typhimurium A1-R regresses an osteosarcoma in a patient-derived xenograft model resistant to a molecular-targeting drug. Oncotarget. 2017 Jan 31; 8(5):8035-8042. Murakami T, Igarashi K, Kawaguchi K, Kiyuna T, Zhang Y, Zhao M, Hiroshima Y, Nelson SD, Dry SM, Li Y, Yanagawa J, Russell T, Federman N, Singh A, Elliott I, Matsuyama R, Chishima T, Tanaka K, Endo I, Eilber FC, Hoffman RM. PMID: 28030831; PMCID: PMC5352380.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    57. Infiltration of CD8 T Cells and Expression of PD-1 and PD-L1 in Synovial Sarcoma. Cancer Immunol Res. 2017 02; 5(2):118-126. Nowicki TS, Akiyama R, Huang RR, Shintaku IP, Wang X, Tumeh PC, Singh A, Chmielowski B, Denny C, Federman N, Ribas A. PMID: 28039162; PMCID: PMC5290092.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    58. Current management of aneurysmal bone cysts. Curr Rev Musculoskelet Med. 2016 Dec; 9(4):435-444. Park HY, Yang SK, Sheppard WL, Hegde V, Zoller SD, Nelson SD, Federman N, Bernthal NM. PMID: 27778155; PMCID: PMC5127951.
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    59. Characterizing the immune microenvironment of malignant peripheral nerve sheath tumor by PD-L1 expression and presence of CD8+ tumor infiltrating lymphocytes. Oncotarget. 2016 Sep 27; 7(39):64300-64308. Shurell E, Singh AS, Crompton JG, Jensen S, Li Y, Dry S, Nelson S, Chmielowski B, Bernthal N, Federman N, Tumeh P, Eilber FC. PMID: 27588404; PMCID: PMC5325443.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    60. Novel association of familial testicular germ cell tumor and autosomal dominant polycystic kidney disease with PKD1 mutation. Pediatr Blood Cancer. 2017 01; 64(1):100-102. Truscott L, Gell J, Chang VY, Lee H, Strom SP, Pillai R, Sisk A, Martinez-Agosto JA, Anderson M, Federman N. PMID: 27577987; PMCID: PMC5937546.
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    61. Sclerostin expression in skeletal sarcomas. Hum Pathol. 2016 12; 58:24-34. Shen J, Meyers CA, Shrestha S, Singh A, LaChaud G, Nguyen V, Asatrian G, Federman N, Bernthal N, Eilber FC, Dry SM, Ting K, Soo C, James AW. PMID: 27498059; PMCID: PMC6560186.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    62. Effective molecular targeting of CDK4/6 and IGF-1R in a rare FUS-ERG fusion CDKN2A-deletion doxorubicin-resistant Ewing's sarcoma patient-derived orthotopic xenograft (PDOX) nude-mouse model. Oncotarget. 2016 Jul 26; 7(30):47556-47564. Murakami T, Singh AS, Kiyuna T, Dry SM, Li Y, James AW, Igarashi K, Kawaguchi K, DeLong JC, Zhang Y, Hiroshima Y, Russell T, Eckardt MA, Yanagawa J, Federman N, Matsuyama R, Chishima T, Tanaka K, Bouvet M, Endo I, Eilber FC, Hoffman RM. PMID: 27286459; PMCID: PMC5216960.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimals
    63. Labeling the Stroma of a Patient-Derived Orthotopic Xenograft (PDOX) Mouse Model of Undifferentiated Pleomorphic Soft-Tissue Sarcoma With Red Fluorescent Protein for Rapid Non-Invasive Imaging for Drug Screening. J Cell Biochem. 2017 02; 118(2):361-365. Kiyuna T, Murakami T, Tome Y, Igarashi K, Kawaguchi K, Russell T, Eckardt MA, Crompton J, Singh A, Bernthal N, Bukata S, Federman N, Kanaya F, Eilber FC, Hoffman RM. PMID: 27357060.
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    64. Prospective immunotherapies in childhood sarcomas: PD1/PDL1 blockade in combination with tumor vaccines. Pediatr Res. 2016 Mar; 79(3):371-7. Nowicki TS, Anderson JL, Federman N. PMID: 26595537.
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    65. Evaluation of In Vitro Activity of the Class I PI3K Inhibitor Buparlisib (BKM120) in Pediatric Bone and Soft Tissue Sarcomas. PLoS One. 2015; 10(9):e0133610. Anderson JL, Park A, Akiyama R, Tap WD, Denny CT, Federman N. PMID: 26402468; PMCID: PMC4581723.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    66. Gender dimorphism and age of onset in malignant peripheral nerve sheath tumor preclinical models and human patients. BMC Cancer. 2014 Nov 15; 14:827. Shurell E, Tran LM, Nakashima J, Smith KB, Tam BM, Li Y, Dry SM, Federman N, Tap WD, Wu H, Eilber FC. PMID: 25398666; PMCID: PMC4237782.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    67. Risk stratification of patients undergoing pulmonary metastasectomy for soft tissue and bone sarcomas. J Thorac Cardiovasc Surg. 2015 Jan; 149(1):85-92. Lin AY, Kotova S, Yanagawa J, Elbuluk O, Wang G, Kar N, Elashoff D, Grogan T, Cameron RB, Singh A, Chmielowski B, Federman N, Nelson SD, Lee P, Eilber FC, Lee JM. PMID: 25312228.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    68. Image-guided percutaneous core needle biopsy of musculoskeletal tumors in children. J Pediatr Hematol Oncol. 2014 Jul; 36(5):337-41. Mitton B, Seeger LL, Eckardt MA, Motamedi K, Eilber FC, Nelson SD, Eckardt JJ, Federman N. PMID: 23588331.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    69. Giant cell tumor of bone in childhood: clinical aspects and novel therapeutic targets. Paediatr Drugs. 2014 Feb; 16(1):21-8. Federman N, Brien EW, Narasimhan V, Dry SM, Sodhi M, Chawla SP. PMID: 24114694.
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    70. Congenital Extrarenal Extra-Central Nervous System Malignant Rhabdoid Tumor of the Upper Extremity: A Case Report. JBJS Case Connect. 2013 Dec 11; 3(4 Suppl 6):e124. Frank JM, Eckardt JJ, Nelson SD, Seeger L, Federman N. PMID: 29252280.
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    71. Safety and efficacy of stereotactic body radiation therapy in the treatment of pulmonary metastases from high grade sarcoma. Sarcoma. 2013; 2013:360214. Mehta N, Selch M, Wang PC, Federman N, Lee JM, Eilber FC, Chmielowski B, Agazaryan N, Steinberg M, Lee P. PMID: 24198717; PMCID: PMC3807836.
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    72. A single-institution retrospective cases series of childhood undifferentiated embryonal liver sarcoma (UELS): success of combined therapy and the use of orthotopic liver transplant. J Pediatr Hematol Oncol. 2013 Aug; 35(6):451-5. Plant AS, Busuttil RW, Rana A, Nelson SD, Auerbach M, Federman NC. PMID: 23138115.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    73. An engineered anti-CA19-9 cys-diabody for positron emission tomography imaging of pancreatic cancer and targeting of polymerized liposomal nanoparticles. J Surg Res. 2013 Nov; 185(1):45-55. Girgis MD, Federman N, Rochefort MM, McCabe KE, Wu AM, Nagy JO, Denny C, Tomlinson JS. PMID: 23827791.
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    74. A child with gemcitabine-induced severe radiation recall myositis resulting in a compartment syndrome. J Pediatr Hematol Oncol. 2013 Mar; 35(2):156-61. Eckardt MA, Bean A, Selch MT, Federman N. PMID: 23274380.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    75. Whole exome sequencing of pediatric gastric adenocarcinoma reveals an atypical presentation of Li-Fraumeni syndrome. Pediatr Blood Cancer. 2013 Apr; 60(4):570-4. Chang VY, Federman N, Martinez-Agosto J, Tatishchev SF, Nelson SF. PMID: 23015295; PMCID: PMC4170733.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    76. Enhanced growth inhibition of osteosarcoma by cytotoxic polymerized liposomal nanoparticles targeting the alcam cell surface receptor. Sarcoma. 2012; 2012:126906. Federman N, Chan J, Nagy JO, Landaw EM, McCabe K, Wu AM, Triche T, Kang H, Liu B, Marks JD, Denny CT. PMID: 23024593; PMCID: PMC3447386.
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    77. Clinical trial end points for assessing efficacy of novel therapies for soft-tissue sarcomas. Expert Rev Anticancer Ther. 2012 Sep; 12(9):1217-28. Chmielowski B, Federman N, Tap WD. PMID: 23098121.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    78. Pediatric sarcomas: translating molecular pathogenesis of disease to novel therapeutic possibilities. Pediatr Res. 2012 Aug; 72(2):112-21. Anderson JL, Denny CT, Tap WD, Federman N. PMID: 22546864; PMCID: PMC4283808.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    79. Long-term results (>25 years) of a randomized, prospective clinical trial evaluating chemotherapy in patients with high-grade, operable osteosarcoma. Cancer. 2012 Dec 01; 118(23):5888-93. Bernthal NM, Federman N, Eilber FR, Nelson SD, Eckardt JJ, Eilber FC, Tap WD. PMID: 22648705.
      View in: PubMed   Mentions: 70     Fields:    Translation:Humans
    80. Alveolar soft part sarcomas: molecular pathogenesis and implications for novel targeted therapies. Sarcoma. 2012; 2012:428789. Mitton B, Federman N. PMID: 22566752; PMCID: PMC3337503.
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    81. Is there a need for dedicated bone imaging in addition to 18F-FDG PET/CT imaging in pediatric sarcoma patients? J Pediatr Hematol Oncol. 2012 Mar; 34(2):131-6. Walter F, Czernin J, Hall T, Allen-Auerbach M, Walter MA, Dunkelmann S, Federman N. PMID: 22134608.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    82. Coexistence of translocation(1,19) and the Philadelphia chromosome in a child's first presentation of chronic myeloid leukemia in blast crisis treated with dasatinib. Pediatr Hematol Oncol. 2011 Nov; 28(8):669-75. Eckardt MA, Chang VY, Rao NP, Federman N. PMID: 22023462.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    83. 18F-fluorodeoxyglucose uptake of bone and soft tissue sarcomas in pediatric patients. Pediatr Hematol Oncol. 2011 Oct; 28(7):579-87. Walter F, Federman N, Apichairuk W, Nelson S, Phelps ME, Allen-Auerbach M, Walter MA, Czernin J. PMID: 21936620.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    84. Extramedullary acute myelocytic leukemia following liver transplantation for VOD with immunodeficiency. J Pediatr Gastroenterol Nutr. 2011 Sep; 53(3):346-9. Wozniak LJ, Yang HM, Lassman CR, Federman N, Wu SS. PMID: 21865981.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    85. Not all hemangiomas are benign--epithelioid hemangioendothelioma: an aggressive vascular lesion in children. Pediatr Hematol Oncol. 2011 Oct; 28(7):622-4. Eckardt MA, Chang VY, Nelson SD, Federman N. PMID: 21787124.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    86. Targeting liposomes toward novel pediatric anticancer therapeutics. Pediatr Res. 2010 May; 67(5):514-9. Federman N, Denny CT. PMID: 20118828.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    87. ABT-869 inhibits the proliferation of Ewing Sarcoma cells and suppresses platelet-derived growth factor receptor beta and c-KIT signaling pathways. Mol Cancer Ther. 2010 Mar; 9(3):653-60. Ikeda AK, Judelson DR, Federman N, Glaser KB, Landaw EM, Denny CT, Sakamoto KM. PMID: 20197394; PMCID: PMC2837519.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    88. Estimated cumulative radiation dose from PET/CT in children with malignancies: a 5-year retrospective review. Pediatr Radiol. 2010 May; 40(5):681-6. Chawla SC, Federman N, Zhang D, Nagata K, Nuthakki S, McNitt-Gray M, Boechat MI. PMID: 19967534; PMCID: PMC2847163.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansPHPublic Health
    89. Utilization of positron emission tomography in the management of patients with sarcoma. Curr Opin Oncol. 2009 Jul; 21(4):345-51. Benz MR, Tchekmedyian N, Eilber FC, Federman N, Czernin J, Tap WD. PMID: 19412096.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    90. The multidisciplinary management of osteosarcoma. Curr Treat Options Oncol. 2009 Apr; 10(1-2):82-93. Federman N, Bernthal N, Eilber FC, Tap WD. PMID: 19238553.
      View in: PubMed   Mentions: 61     Fields:    Translation:Humans
    91. PET/CT in evaluating pediatric malignancies: a clinician's perspective. J Nucl Med. 2007 Dec; 48(12):1920-2. Federman N, Feig SA. PMID: 18056331.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    92. Targeted therapies for soft-tissue sarcomas. Expert Rev Anticancer Ther. 2007 May; 7(5):725-33. Tap WD, Federman N, Eilber FC. PMID: 17492935.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    93. The genetic basis of bone marrow failure syndromes in children. Mol Genet Metab. 2005 Sep-Oct; 86(1-2):100-9. Federman N, Sakamoto KM. PMID: 16125992.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    94. Topics in pediatric leukemia--Fanconi's anemia: new insights. MedGenMed. 2005 Apr 06; 7(2):23. Federman N, Sakamoto KM. PMID: 16369402; PMCID: PMC1681561.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    95. The role of CREB as a proto-oncogene in hematopoiesis and in acute myeloid leukemia. Cancer Cell. 2005 Apr; 7(4):351-62. Shankar DB, Cheng JC, Kinjo K, Federman N, Moore TB, Gill A, Rao NP, Landaw EM, Sakamoto KM. PMID: 15837624.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansAnimalsCells
    96. Bilateral microtia and cleft palate in cousins with Diamond-Blackfan anemia. Am J Med Genet. 2001 Jul 01; 101(3):268-74. Gripp KW, McDonald-McGinn DM, La Rossa D, McGain D, Federman N, Vlachos A, Glader BE, McKenzie SE, Lipton JM, Zackai EH. PMID: 11424144.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    97. Hematopoietic stem cell transplantation for Diamond Blackfan anemia: a report from the Diamond Blackfan Anemia Registry. Bone Marrow Transplant. 2001 Feb; 27(4):381-6. Vlachos A, Federman N, Reyes-Haley C, Abramson J, Lipton JM. PMID: 11313667.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
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