Christopher Denny

Title(s)Professor, Pediatrics
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    Collapse Biography 
    Collapse Education and Training
    University of Pennsylvania, Philadelphia, PAB.A.1976Chemistry
    University of Pennsylvania School of Medicine, Philadelphia, PAMD1980
    Collapse Awards and Honors
    University of Pennsylvania1976Phi Beta Kappa, Delta Chapter
    Pennsylvania Institutes of Chemists, Philadelphia Chapter1976American Institute of Chemists’ Medal for Outstanding Scholastic Achievement
    University of Pennsylvania1978Thurman S. Schnabell University Scholarship
    University of Pennsylvania School of Medicine1979Alpha Omega Alpha
    American Cancer Society1989  - 1992Junior Faculty Research Award
    Leukemia Society of America1992  - 1997Leukemia Society Scholar Award
    Western Society for Pediatric Research1993Ross Award for Pediatric Research
    1998American Society for Clinical Research

    Collapse Overview 
    Collapse Overview
    Throughout Dr. Christopher Denny’s 33-year career at UCLA, his greatest creative potential has been in forging links between diverse fields. Most of his academic success has come through applying basic molecular biology tools to seek molecular mechanisms for what he witnesses when treating pediatric hematology/oncology patients. Over the last several years, his focus has shifted towards developing strategies and tools that would have a more direct clinical impact. For example, he helped create the electronic medical record system for UCLA Healthcare and continues to play an active role in its development. In 2014, he became board certified in the new specialty of Clinical Informatics. As a program director within UCLA’s Clinical and Translational Science Institute, he developed a voucher system to support and facilitate use of core services across our four campuses. This program proved to be a paradigm shift away from directly subsidizing cores and towards supporting investigator defined projects. For the last year, he has been leading an effort to create a scalable and flexible genomic repository in service of our Precision Health Institute.

    Collapse Research 
    Collapse Research Activities and Funding
    UCLA Clinical Translational Science Institute
    NIH UL1TR001881Jul 1, 2016 - May 31, 2022
    Role: Co-Investigator, Pilot Program
    Defining Mechanisms of Tumorigenesis by EWS/ETS Fusions
    NIH R01CA087771Jul 1, 2000 - Jun 30, 2012
    Role: Principal Investigator
    NIH U10CA078969Aug 5, 1998 - Jul 31, 2000
    Role: Principal Investigator
    NIH R01CA050443Jul 1, 1989 - Apr 30, 1994
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Author Correction: Leveraging genomic diversity for discovery in an electronic health record linked biobank: the UCLA ATLAS Community Health Initiative. Genome Med. 2022 Nov 16; 14(1):128. Johnson R, Ding Y, Venkateswaran V, Bhattacharya A, Boulier K, Chiu A, Knyazev S, Schwarz T, Freund M, Zhan L, Burch KS, Caggiano C, Hill B, Rakocz N, Balliu B, Denny CT, Sul JH, Zaitlen N, Arboleda VA, Halperin E, Sankararaman S, Butte MJ, UCLA Precision Health Data Discovery Repository Working Group, UCLA Precision Health ATLAS Working G, Lajonchere C, Geschwind DH, Pasaniuc B. PMID: 36384576; PMCID: PMC9670414.
      View in: PubMed   Mentions:    Fields:    
    2. Leveraging genomic diversity for discovery in an electronic health record linked biobank: the UCLA ATLAS Community Health Initiative. Genome Med. 2022 Sep 09; 14(1):104. Johnson R, Ding Y, Venkateswaran V, Bhattacharya A, Boulier K, Chiu A, Knyazev S, Schwarz T, Freund M, Zhan L, Burch KS, Caggiano C, Hill B, Rakocz N, Balliu B, Denny CT, Sul JH, Zaitlen N, Arboleda VA, Halperin E, Sankararaman S, Butte MJ, UCLA Precision Health Data Discovery Repository Working Group, UCLA Precision Health ATLAS Working G, Lajonchere C, Geschwind DH, Pasaniuc B. PMID: 36085083; PMCID: PMC9461263.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansPHPublic Health
    3. SARS-CoV-2 Infection Detection by PCR and Serologic Testing in Clinical Practice. J Clin Microbiol. 2021 06 18; 59(7):e0043121. Murad D, Chandrasekaran S, Pillai A, Garner OB, Denny CT. PMID: 33903168; PMCID: PMC8218740.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    4. Advancing clinical cohort selection with genomics analysis on a distributed platform. PLoS One. 2020; 15(4):e0231826. Smith JM, Lathara M, Wright H, Hill B, Ganapati N, Srinivasa G, Denny CT. PMID: 32324802; PMCID: PMC7179830.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Erratum: Describing the dynamic translational science landscape through core voucher utilization - ERRATUM. J Clin Transl Sci. 2020 Feb; 4(1):73. Liclican EL, Filler SG, Kaye J, Denny CT. PMID: 32257414; PMCID: PMC7103460.
      View in: PubMed   Mentions:
    6. Describing the dynamic translational science landscape through Core Voucher utilization. J Clin Transl Sci. 2019 Jun; 3(2-3):105-112. Liclican EL, Filler SG, Kaye J, Denny CT. PMID: 31660233; PMCID: PMC6802412.
      View in: PubMed   Mentions: 1  
    7. Infiltration of CD8 T Cells and Expression of PD-1 and PD-L1 in Synovial Sarcoma. Cancer Immunol Res. 2017 02; 5(2):118-126. Nowicki TS, Akiyama R, Huang RR, Shintaku IP, Wang X, Tumeh PC, Singh A, Chmielowski B, Denny C, Federman N, Ribas A. PMID: 28039162; PMCID: PMC5290092.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    8. Evaluation of In Vitro Activity of the Class I PI3K Inhibitor Buparlisib (BKM120) in Pediatric Bone and Soft Tissue Sarcomas. PLoS One. 2015; 10(9):e0133610. Anderson JL, Park A, Akiyama R, Tap WD, Denny CT, Federman N. PMID: 26402468; PMCID: PMC4581723.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    9. ChIP-ping away at EWS/ETS transcription networks. Cancer Cell. 2014 Nov 10; 26(5):595-6. Denny CT. PMID: 25517742.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    10. Phosphoproteomic profiling reveals IL6-mediated paracrine signaling within the Ewing sarcoma family of tumors. Mol Cancer Res. 2014 Dec; 12(12):1740-54. Anderson JL, Titz B, Akiyama R, Komisopoulou E, Park A, Tap WD, Graeber TG, Denny CT. PMID: 25092916.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    11. An engineered anti-CA19-9 cys-diabody for positron emission tomography imaging of pancreatic cancer and targeting of polymerized liposomal nanoparticles. J Surg Res. 2013 Nov; 185(1):45-55. Girgis MD, Federman N, Rochefort MM, McCabe KE, Wu AM, Nagy JO, Denny C, Tomlinson JS. PMID: 23827791.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    12. Enhanced growth inhibition of osteosarcoma by cytotoxic polymerized liposomal nanoparticles targeting the alcam cell surface receptor. Sarcoma. 2012; 2012:126906. Federman N, Chan J, Nagy JO, Landaw EM, McCabe K, Wu AM, Triche T, Kang H, Liu B, Marks JD, Denny CT. PMID: 23024593; PMCID: PMC3447386.
      View in: PubMed   Mentions: 19  
    13. Pediatric sarcomas: translating molecular pathogenesis of disease to novel therapeutic possibilities. Pediatr Res. 2012 Aug; 72(2):112-21. Anderson JL, Denny CT, Tap WD, Federman N. PMID: 22546864; PMCID: PMC4283808.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    14. Oncogenic fusion protein EWS/FLI1 down-regulates gene expression by both transcriptional and posttranscriptional mechanisms. J Biol Chem. 2011 Jul 01; 286(26):22750-7. France KA, Anderson JL, Park A, Denny CT. PMID: 21531709; PMCID: PMC3123042.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    15. Targeting liposomes toward novel pediatric anticancer therapeutics. Pediatr Res. 2010 May; 67(5):514-9. Federman N, Denny CT. PMID: 20118828.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    16. ABT-869 inhibits the proliferation of Ewing Sarcoma cells and suppresses platelet-derived growth factor receptor beta and c-KIT signaling pathways. Mol Cancer Ther. 2010 Mar; 9(3):653-60. Ikeda AK, Judelson DR, Federman N, Glaser KB, Landaw EM, Denny CT, Sakamoto KM. PMID: 20197394; PMCID: PMC2837519.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    17. Genetically defined EWS/FLI1 model system suggests mesenchymal origin of Ewing's family tumors. Lab Invest. 2008 Dec; 88(12):1291-302. Potikyan G, France KA, Carlson MR, Dong J, Nelson SF, Denny CT. PMID: 18838963.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    18. EWS/FLI1 regulates tumor angiogenesis in Ewing's sarcoma via suppression of thrombospondins. Cancer Res. 2007 Jul 15; 67(14):6675-84. Potikyan G, Savene RO, Gaulden JM, France KA, Zhou Z, Kleinerman ES, Lessnick SL, Denny CT. PMID: 17638877.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    19. Multiple aromatic side chains within a disordered structure are critical for transcription and transforming activity of EWS family oncoproteins. Proc Natl Acad Sci U S A. 2007 Jan 09; 104(2):479-84. Ng KP, Potikyan G, Savene RO, Denny CT, Uversky VN, Lee KA. PMID: 17202261; PMCID: PMC1766410.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    20. Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers. Cancer Cell. 2006 Jun; 9(6):473-84. Davis IJ, Kim JJ, Ozsolak F, Widlund HR, Rozenblatt-Rosen O, Granter SR, Du J, Fletcher JA, Denny CT, Lessnick SL, Linehan WM, Kung AL, Fisher DE. PMID: 16766266.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    21. Cooperative DNA binding with AP-1 proteins is required for transformation by EWS-Ets fusion proteins. Mol Cell Biol. 2006 Apr; 26(7):2467-78. Kim S, Denny CT, Wisdom R. PMID: 16537893; PMCID: PMC1430316.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    22. Functional analysis of the EWS/ETS target gene uridine phosphorylase. Cancer Res. 2003 Jul 15; 63(14):4268-74. Deneen B, Hamidi H, Denny CT. PMID: 12874036.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    23. PIM3 proto-oncogene kinase is a common transcriptional target of divergent EWS/ETS oncoproteins. Mol Cell Biol. 2003 Jun; 23(11):3897-908. Deneen B, Welford SM, Ho T, Hernandez F, Kurland I, Denny CT. PMID: 12748291; PMCID: PMC155223.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    24. Focus on embryonal malignancies. Cancer Cell. 2002 Dec; 2(6):447-50. Maris JM, Denny CT. PMID: 12498713.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
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