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Christopher Denny

Title(s)Professor, Pediatrics
SchoolMedicine
Address760 Westwood Plaza 12-311
Los Angeles CA 90024
Phone50704
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    Collapse Research 
    Collapse Research Activities and Funding
    Defining Mechanisms of Tumorigenesis by EWS/ETS Fusions
    NIH/NCI R01CA087771Jul 1, 2000 - Nov 30, 2010
    Role: Principal Investigator
    ASSESSING GENE EXPRESSION IN PEDIATRIC TUMORS
    NIH/NCI U10CA078969Aug 5, 1998 - Jul 31, 2000
    Role: Principal Investigator
    MOLECULAR STUDY OF EWING SARCOMA T 11-22 TRANSLOCATION
    NIH/NCI R01CA050443Jul 1, 1989 - Apr 30, 1994
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Describing the dynamic translational science landscape through Core Voucher utilization. J Clin Transl Sci. 2019 Jun; 3(2-3):105-112. Liclican EL, Filler SG, Kaye J, Denny CT. PMID: 31660233.
      View in: PubMed   Mentions:
    2. Infiltration of CD8 T Cells and Expression of PD-1 and PD-L1 in Synovial Sarcoma. Cancer Immunol Res. 2017 02; 5(2):118-126. Nowicki TS, Akiyama R, Huang RR, Shintaku IP, Wang X, Tumeh PC, Singh A, Chmielowski B, Denny C, Federman N, Ribas A. PMID: 28039162.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    3. ChIP-ping away at EWS/ETS transcription networks. Cancer Cell. 2014 Nov 10; 26(5):595-6. Denny CT. PMID: 25517742.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    4. Phosphoproteomic profiling reveals IL6-mediated paracrine signaling within the Ewing sarcoma family of tumors. Mol Cancer Res. 2014 Dec; 12(12):1740-54. Anderson JL, Titz B, Akiyama R, Komisopoulou E, Park A, Tap WD, Graeber TG, Denny CT. PMID: 25092916.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    5. Pediatric sarcomas: translating molecular pathogenesis of disease to novel therapeutic possibilities. Pediatr Res. 2012 Aug; 72(2):112-21. Anderson JL, Denny CT, Tap WD, Federman N. PMID: 22546864.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    6. Oncogenic fusion protein EWS/FLI1 down-regulates gene expression by both transcriptional and posttranscriptional mechanisms. J Biol Chem. 2011 Jul 01; 286(26):22750-7. France KA, Anderson JL, Park A, Denny CT. PMID: 21531709.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    7. ABT-869 inhibits the proliferation of Ewing Sarcoma cells and suppresses platelet-derived growth factor receptor beta and c-KIT signaling pathways. Mol Cancer Ther. 2010 Mar; 9(3):653-60. Ikeda AK, Judelson DR, Federman N, Glaser KB, Landaw EM, Denny CT, Sakamoto KM. PMID: 20197394.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    8. Genetically defined EWS/FLI1 model system suggests mesenchymal origin of Ewing's family tumors. Lab Invest. 2008 Dec; 88(12):1291-302. Potikyan G, France KA, Carlson MR, Dong J, Nelson SF, Denny CT. PMID: 18838963.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    9. EWS/FLI1 regulates tumor angiogenesis in Ewing's sarcoma via suppression of thrombospondins. Cancer Res. 2007 Jul 15; 67(14):6675-84. Potikyan G, Savene RO, Gaulden JM, France KA, Zhou Z, Kleinerman ES, Lessnick SL, Denny CT. PMID: 17638877.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    10. Multiple aromatic side chains within a disordered structure are critical for transcription and transforming activity of EWS family oncoproteins. Proc Natl Acad Sci U S A. 2007 Jan 09; 104(2):479-84. Ng KP, Potikyan G, Savene RO, Denny CT, Uversky VN, Lee KA. PMID: 17202261.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    11. Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers. Cancer Cell. 2006 Jun; 9(6):473-84. Davis IJ, Kim JJ, Ozsolak F, Widlund HR, Rozenblatt-Rosen O, Granter SR, Du J, Fletcher JA, Denny CT, Lessnick SL, Linehan WM, Kung AL, Fisher DE. PMID: 16766266.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    12. Cooperative DNA binding with AP-1 proteins is required for transformation by EWS-Ets fusion proteins. Mol Cell Biol. 2006 Apr; 26(7):2467-78. Kim S, Denny CT, Wisdom R. PMID: 16537893.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    13. Functional analysis of the EWS/ETS target gene uridine phosphorylase. Cancer Res. 2003 Jul 15; 63(14):4268-74. Deneen B, Hamidi H, Denny CT. PMID: 12874036.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    14. PIM3 proto-oncogene kinase is a common transcriptional target of divergent EWS/ETS oncoproteins. Mol Cell Biol. 2003 Jun; 23(11):3897-908. Deneen B, Welford SM, Ho T, Hernandez F, Kurland I, Denny CT. PMID: 12748291.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    15. Focus on embryonal malignancies. Cancer Cell. 2002 Dec; 2(6):447-50. Maris JM, Denny CT. PMID: 12498713.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
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