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Denny, Christopher

Title(s)Professor, Pediatrics
SchoolPed - Hematology And Oncology
Phone50704
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    Defining Mechanisms of Tumorigenesis by EWS/ETS Fusions
    NIH/NCI R01CA087771Jul 1, 2000 - Nov 30, 2010
    Role: Principal Investigator
    ASSESSING GENE EXPRESSION IN PEDIATRIC TUMORS
    NIH/NCI U10CA078969Aug 5, 1998 - Jul 31, 2000
    Role: Principal Investigator
    MOLECULAR STUDY OF EWING SARCOMA T 11-22 TRANSLOCATION
    NIH/NCI R01CA050443Jul 1, 1989 - Apr 30, 1994
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Liclican EL, Filler SG, Kaye J, Denny CT. Describing the dynamic translational science landscape through Core Voucher utilization. J Clin Transl Sci. 2019 Jun; 3(2-3):105-112. PMID: 31660233.
      View in: PubMed
    2. Nowicki TS, Akiyama R, Huang RR, Shintaku IP, Wang X, Tumeh PC, Singh A, Chmielowski B, Denny C, Federman N, Ribas A. Infiltration of CD8 T Cells and Expression of PD-1 and PD-L1 in Synovial Sarcoma. Cancer Immunol Res. 2017 02; 5(2):118-126. PMID: 28039162.
      View in: PubMed
    3. Denny CT. ChIP-ping away at EWS/ETS transcription networks. Cancer Cell. 2014 Nov 10; 26(5):595-6. PMID: 25517742.
      View in: PubMed
    4. Anderson JL, Titz B, Akiyama R, Komisopoulou E, Park A, Tap WD, Graeber TG, Denny CT. Phosphoproteomic profiling reveals IL6-mediated paracrine signaling within the Ewing sarcoma family of tumors. Mol Cancer Res. 2014 Dec; 12(12):1740-54. PMID: 25092916.
      View in: PubMed
    5. Anderson JL, Denny CT, Tap WD, Federman N. Pediatric sarcomas: translating molecular pathogenesis of disease to novel therapeutic possibilities. Pediatr Res. 2012 Aug; 72(2):112-21. PMID: 22546864.
      View in: PubMed
    6. France KA, Anderson JL, Park A, Denny CT. Oncogenic fusion protein EWS/FLI1 down-regulates gene expression by both transcriptional and posttranscriptional mechanisms. J Biol Chem. 2011 Jul 01; 286(26):22750-7. PMID: 21531709.
      View in: PubMed
    7. Ikeda AK, Judelson DR, Federman N, Glaser KB, Landaw EM, Denny CT, Sakamoto KM. ABT-869 inhibits the proliferation of Ewing Sarcoma cells and suppresses platelet-derived growth factor receptor beta and c-KIT signaling pathways. Mol Cancer Ther. 2010 Mar; 9(3):653-60. PMID: 20197394.
      View in: PubMed
    8. Potikyan G, France KA, Carlson MR, Dong J, Nelson SF, Denny CT. Genetically defined EWS/FLI1 model system suggests mesenchymal origin of Ewing's family tumors. Lab Invest. 2008 Dec; 88(12):1291-302. PMID: 18838963.
      View in: PubMed
    9. Potikyan G, Savene RO, Gaulden JM, France KA, Zhou Z, Kleinerman ES, Lessnick SL, Denny CT. EWS/FLI1 regulates tumor angiogenesis in Ewing's sarcoma via suppression of thrombospondins. Cancer Res. 2007 Jul 15; 67(14):6675-84. PMID: 17638877.
      View in: PubMed
    10. Ng KP, Potikyan G, Savene RO, Denny CT, Uversky VN, Lee KA. Multiple aromatic side chains within a disordered structure are critical for transcription and transforming activity of EWS family oncoproteins. Proc Natl Acad Sci U S A. 2007 Jan 09; 104(2):479-84. PMID: 17202261.
      View in: PubMed
    11. Davis IJ, Kim JJ, Ozsolak F, Widlund HR, Rozenblatt-Rosen O, Granter SR, Du J, Fletcher JA, Denny CT, Lessnick SL, Linehan WM, Kung AL, Fisher DE. Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers. Cancer Cell. 2006 Jun; 9(6):473-84. PMID: 16766266.
      View in: PubMed
    12. Kim S, Denny CT, Wisdom R. Cooperative DNA binding with AP-1 proteins is required for transformation by EWS-Ets fusion proteins. Mol Cell Biol. 2006 Apr; 26(7):2467-78. PMID: 16537893.
      View in: PubMed
    13. Deneen B, Hamidi H, Denny CT. Functional analysis of the EWS/ETS target gene uridine phosphorylase. Cancer Res. 2003 Jul 15; 63(14):4268-74. PMID: 12874036.
      View in: PubMed
    14. Deneen B, Welford SM, Ho T, Hernandez F, Kurland I, Denny CT. PIM3 proto-oncogene kinase is a common transcriptional target of divergent EWS/ETS oncoproteins. Mol Cell Biol. 2003 Jun; 23(11):3897-908. PMID: 12748291.
      View in: PubMed
    15. Maris JM, Denny CT. Focus on embryonal malignancies. Cancer Cell. 2002 Dec; 2(6):447-50. PMID: 12498713.
      View in: PubMed
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