Christopher Denny
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Title(s) | Professor, Pediatrics |
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School | Medicine |
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Address | 760 Westwood Plaza 12-311 Los Angeles CA 90024
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Phone | 50704 |
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vCard | Download vCard |
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Biography University of Pennsylvania, Philadelphia, PA | B.A. | 1976 | Chemistry | University of Pennsylvania School of Medicine, Philadelphia, PA | MD | 1980 | |
University of Pennsylvania | 1976 | | Phi Beta Kappa, Delta Chapter | Pennsylvania Institutes of Chemists, Philadelphia Chapter | 1976 | | American Institute of Chemists’ Medal for Outstanding Scholastic Achievement | University of Pennsylvania | 1978 | | Thurman S. Schnabell University Scholarship | University of Pennsylvania School of Medicine | 1979 | | Alpha Omega Alpha | American Cancer Society | 1989
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| 1992 | Junior Faculty Research Award | Leukemia Society of America | 1992
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| 1997 | Leukemia Society Scholar Award | Western Society for Pediatric Research | 1993 | | Ross Award for Pediatric Research | | 1998 | | American Society for Clinical Research |
Overview Throughout Dr. Christopher Denny’s 33-year career at UCLA, his greatest creative potential has been in forging links between diverse fields. Most of his academic success has come through applying basic molecular biology tools to seek molecular mechanisms for what he witnesses when treating pediatric hematology/oncology patients. Over the last several years, his focus has shifted towards developing strategies and tools that would have a more direct clinical impact. For example, he helped create the electronic medical record system for UCLA Healthcare and continues to play an active role in its development. In 2014, he became board certified in the new specialty of Clinical Informatics. As a program director within UCLA’s Clinical and Translational Science Institute, he developed a voucher system to support and facilitate use of core services across our four campuses. This program proved to be a paradigm shift away from directly subsidizing cores and towards supporting investigator defined projects. For the last year, he has been leading an effort to create a scalable and flexible genomic repository in service of our Precision Health Institute.
Research ORNG Applications Bibliographic
Altmetrics Details
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Advancing clinical cohort selection with genomics analysis on a distributed platform. PLoS One. 2020; 15(4):e0231826.
Smith JM, Lathara M, Wright H, Hill B, Ganapati N, Srinivasa G, Denny CT. PMID: 32324802.
View in: PubMed Mentions: Fields: Translation: Humans
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Erratum: Describing the dynamic translational science landscape through core voucher utilization - ERRATUM. J Clin Transl Sci. 2020 Feb; 4(1):73.
Liclican EL, Filler SG, Kaye J, Denny CT. PMID: 32257414.
View in: PubMed Mentions:
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Describing the dynamic translational science landscape through Core Voucher utilization. J Clin Transl Sci. 2019 Jun; 3(2-3):105-112.
Liclican EL, Filler SG, Kaye J, Denny CT. PMID: 31660233.
View in: PubMed Mentions:
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Infiltration of CD8 T Cells and Expression of PD-1 and PD-L1 in Synovial Sarcoma. Cancer Immunol Res. 2017 02; 5(2):118-126.
Nowicki TS, Akiyama R, Huang RR, Shintaku IP, Wang X, Tumeh PC, Singh A, Chmielowski B, Denny C, Federman N, Ribas A. PMID: 28039162.
View in: PubMed Mentions: 14 Fields: Translation: HumansCells
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Evaluation of In Vitro Activity of the Class I PI3K Inhibitor Buparlisib (BKM120) in Pediatric Bone and Soft Tissue Sarcomas. PLoS One. 2015; 10(9):e0133610.
Anderson JL, Park A, Akiyama R, Tap WD, Denny CT, Federman N. PMID: 26402468.
View in: PubMed Mentions: 8 Fields: Translation: HumansCells
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ChIP-ping away at EWS/ETS transcription networks. Cancer Cell. 2014 Nov 10; 26(5):595-6.
Denny CT. PMID: 25517742.
View in: PubMed Mentions: Fields: Translation: HumansAnimals
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Phosphoproteomic profiling reveals IL6-mediated paracrine signaling within the Ewing sarcoma family of tumors. Mol Cancer Res. 2014 Dec; 12(12):1740-54.
Anderson JL, Titz B, Akiyama R, Komisopoulou E, Park A, Tap WD, Graeber TG, Denny CT. PMID: 25092916.
View in: PubMed Mentions: 6 Fields: Translation: HumansCells
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An engineered anti-CA19-9 cys-diabody for positron emission tomography imaging of pancreatic cancer and targeting of polymerized liposomal nanoparticles. J Surg Res. 2013 Nov; 185(1):45-55.
Girgis MD, Federman N, Rochefort MM, McCabe KE, Wu AM, Nagy JO, Denny C, Tomlinson JS. PMID: 23827791.
View in: PubMed Mentions: 10 Fields: Translation: HumansAnimalsCells
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Enhanced growth inhibition of osteosarcoma by cytotoxic polymerized liposomal nanoparticles targeting the alcam cell surface receptor. Sarcoma. 2012; 2012:126906.
Federman N, Chan J, Nagy JO, Landaw EM, McCabe K, Wu AM, Triche T, Kang H, Liu B, Marks JD, Denny CT. PMID: 23024593.
View in: PubMed Mentions:
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Pediatric sarcomas: translating molecular pathogenesis of disease to novel therapeutic possibilities. Pediatr Res. 2012 Aug; 72(2):112-21.
Anderson JL, Denny CT, Tap WD, Federman N. PMID: 22546864.
View in: PubMed Mentions: 13 Fields: Translation: HumansCells
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Oncogenic fusion protein EWS/FLI1 down-regulates gene expression by both transcriptional and posttranscriptional mechanisms. J Biol Chem. 2011 Jul 01; 286(26):22750-7.
France KA, Anderson JL, Park A, Denny CT. PMID: 21531709.
View in: PubMed Mentions: 13 Fields: Translation: HumansAnimalsCells
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Targeting liposomes toward novel pediatric anticancer therapeutics. Pediatr Res. 2010 May; 67(5):514-9.
Federman N, Denny CT. PMID: 20118828.
View in: PubMed Mentions: 5 Fields: Translation: Humans
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ABT-869 inhibits the proliferation of Ewing Sarcoma cells and suppresses platelet-derived growth factor receptor beta and c-KIT signaling pathways. . 2010 Mar; 9(3):653-60.
Ikeda AK, Judelson DR, Federman N, Glaser KB, Landaw EM, Denny CT, Sakamoto KM. PMID: 20197394.
View in: PubMed Mentions:
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Genetically defined EWS/FLI1 model system suggests mesenchymal origin of Ewing's family tumors. Lab Invest. 2008 Dec; 88(12):1291-302.
Potikyan G, France KA, Carlson MR, Dong J, Nelson SF, Denny CT. PMID: 18838963.
View in: PubMed Mentions: 16 Fields: Translation: HumansCells
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EWS/FLI1 regulates tumor angiogenesis in Ewing's sarcoma via suppression of thrombospondins. Cancer Res. 2007 Jul 15; 67(14):6675-84.
Potikyan G, Savene RO, Gaulden JM, France KA, Zhou Z, Kleinerman ES, Lessnick SL, Denny CT. PMID: 17638877.
View in: PubMed Mentions: 14 Fields: Translation: HumansAnimalsCells
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Multiple aromatic side chains within a disordered structure are critical for transcription and transforming activity of EWS family oncoproteins. Proc Natl Acad Sci U S A. 2007 Jan 09; 104(2):479-84.
Ng KP, Potikyan G, Savene RO, Denny CT, Uversky VN, Lee KA. PMID: 17202261.
View in: PubMed Mentions: 39 Fields: Translation: HumansAnimalsCells
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Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers. Cancer Cell. 2006 Jun; 9(6):473-84.
Davis IJ, Kim JJ, Ozsolak F, Widlund HR, Rozenblatt-Rosen O, Granter SR, Du J, Fletcher JA, Denny CT, Lessnick SL, Linehan WM, Kung AL, Fisher DE. PMID: 16766266.
View in: PubMed Mentions: 48 Fields: Translation: HumansAnimalsCells
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Cooperative DNA binding with AP-1 proteins is required for transformation by EWS-Ets fusion proteins. Mol Cell Biol. 2006 Apr; 26(7):2467-78.
Kim S, Denny CT, Wisdom R. PMID: 16537893.
View in: PubMed Mentions: 26 Fields: Translation: AnimalsCells
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Functional analysis of the EWS/ETS target gene uridine phosphorylase. Cancer Res. 2003 Jul 15; 63(14):4268-74.
Deneen B, Hamidi H, Denny CT. PMID: 12874036.
View in: PubMed Mentions: 15 Fields: Translation: HumansAnimalsCells
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PIM3 proto-oncogene kinase is a common transcriptional target of divergent EWS/ETS oncoproteins. Mol Cell Biol. 2003 Jun; 23(11):3897-908.
Deneen B, Welford SM, Ho T, Hernandez F, Kurland I, Denny CT. PMID: 12748291.
View in: PubMed Mentions: 18 Fields: Translation: HumansAnimalsCells
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Focus on embryonal malignancies. Cancer Cell. 2002 Dec; 2(6):447-50.
Maris JM, Denny CT. PMID: 12498713.
View in: PubMed Mentions: 10 Fields: Translation: Humans
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Year | Publications |
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2002 | 1 | 2003 | 2 | 2006 | 2 | 2007 | 2 | 2008 | 1 | 2010 | 2 | 2011 | 1 | 2012 | 2 | 2013 | 1 | 2014 | 2 | 2015 | 1 | 2016 | 1 | 2019 | 2 | 2020 | 1 |
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Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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