Noah A Zaitlen

Title(s)Professor, Neurology
SchoolMedicine
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    Other Positions
    Title(s)Professor, Human Genetics


    Collapse Research 
    Collapse Research Activities and Funding
    Leveraging genetic variation to dissect gene regulatory networks of reprogramming to pluripotency
    NIH U01HG012079Sep 1, 2021 - May 31, 2026
    Role: Co-Principal Investigator
    Epigenomics of asthma risk factors and clinical subtypes in minority children
    NIH R01HL155024Jan 1, 2021 - Nov 30, 2024
    Role: Co-Principal Investigator
    Genomic Approaches to Population Health in Multi-Ethnic Hospital Systems
    NIH R01HG011345Sep 16, 2020 - Jul 31, 2024
    Role: Co-Principal Investigator
    Improved methods for inference of genotype-specific response to environmental toxins
    NIH R01ES029929Feb 1, 2019 - Jan 31, 2024
    Role: Co-Principal Investigator
    Epigenetics of Socio-Environmental Effects on Asthma in Minorities
    NIH R56MD013312Sep 25, 2018 - Sep 24, 2020
    Role: Principal Investigator
    (PQ3) A functional genomic approach to identification and interpretation of germline-tumor genetic interactions
    NIH R01CA227237Jun 8, 2018 - May 31, 2023
    Role: Co-Principal Investigator
    Leveraging Novel Multivariate Methods of Subphenotypes in Genetic Association Studies of Sjogren?s Syndrome
    NIH R03DE025665Sep 2, 2016 - Aug 31, 2018
    Role: Co-Principal Investigator
    Richer Models of Asthma Risk: Bridging the Environment-Genetics Divide
    NIH K25HL121295Aug 1, 2014 - Oct 31, 2019
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Strong effect of demographic changes on Tuberculosis susceptibility in South Africa. PLOS Glob Public Health. 2024; 4(7):e0002643. Oyageshio OP, Myrick JW, Saayman J, van der Westhuizen L, Al-Hindi DR, Reynolds AW, Zaitlen N, Hoal EG, Uren C, Möller M, Henn BM. PMID: 39042651; PMCID: PMC11265723.
      View in: PubMed   Mentions: 1  
    2. Author Correction: Multi-ancestry polygenic mechanisms of type 2 diabetes. Nat Med. 2024 Jul; 30(7):2091. Smith K, Deutsch AJ, McGrail C, Kim H, Hsu S, Huerta-Chagoya A, Mandla R, Schroeder PH, Westerman KE, Szczerbinski L, Majarian TD, Kaur V, Williamson A, Zaitlen N, Claussnitzer M, Florez JC, Manning AK, Mercader JM, Gaulton KJ, Udler MS. PMID: 38760590.
      View in: PubMed   Mentions:    Fields:    
    3. Single-stranded pre-methylated 5mC adapters uncover the methylation profile of plasma ultrashort Single-stranded cell-free DNA. Nucleic Acids Res. 2024 Jun 24; 52(11):e50. Cheng JC, Swarup N, Morselli M, Huang WL, Aziz M, Caggiano C, Kordi M, Patel AA, Chia D, Kim Y, Li F, Wei F, Zaitlen N, Krysan K, Dubinett S, Pellegrini M, Wong DTW. PMID: 38797520; PMCID: PMC11194076.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    4. A scalable and robust variance components method reveals insights into the architecture of gene-environment interactions underlying complex traits. Am J Hum Genet. 2024 07 11; 111(7):1462-1480. Pazokitoroudi A, Liu Z, Dahl A, Zaitlen N, Rosset S, Sankararaman S. PMID: 38866020; PMCID: PMC11267529.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Brain cell-type shifts in Alzheimer's disease, autism, and schizophrenia interrogated using methylomics and genetics. Sci Adv. 2024 May 24; 10(21):eadn7655. Yap CX, Vo DD, Heffel MG, Bhattacharya A, Wen C, Yang Y, Kemper KE, Zeng J, Zheng Z, Zhu Z, Hannon E, Vellame DS, Franklin A, Caggiano C, Wamsley B, Geschwind DH, Zaitlen N, Gusev A, Pasaniuc B, Mill J, Luo C, Gandal MJ. PMID: 38781333; PMCID: PMC11114225.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    6. MANOCCA: a robust and computationally efficient test of covariance in high-dimension multivariate omics data. Brief Bioinform. 2024 May 23; 25(4). Boetto C, Frouin A, Henches L, Auvergne A, Suzuki Y, Patin E, Bredon M, Chiu A, Consortium MI, Sankararaman S, Zaitlen N, Kennedy SP, Quintana-Murci L, Duffy D, Sokol H, Aschard H. PMID: 38856173; PMCID: PMC11163461.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Electronic health record signatures identify undiagnosed patients with common variable immunodeficiency disease. Sci Transl Med. 2024 May; 16(745):eade4510. Johnson R, Stephens AV, Mester R, Knyazev S, Kohn LA, Freund MK, Bondhus L, Hill BL, Schwarz T, Zaitlen N, Arboleda VA, A Bastarache L, Pasaniuc B, Butte MJ. PMID: 38691621; PMCID: PMC11402387.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    8. Investigating the sources of variable impact of pathogenic variants in monogenic metabolic conditions. medRxiv. 2024 May 01. Wei A, Border R, Fu B, Cullina S, Brandes N, Jang SK, Sankararaman S, Kenny E, Udler MS, Ntranos V, Zaitlen N, Arboleda V. PMID: 37745486; PMCID: PMC10516069.
      View in: PubMed   Mentions:
    9. Tissue informative cell-free DNA methylation sites in amyotrophic lateral sclerosis. medRxiv. 2024 Apr 10. Caggiano C, Morselli M, Qian X, Celona B, Thompson M, Wani S, Tosevska A, Taraszka K, Heuer G, Ngo S, Steyn F, Nestor P, Wallace L, McCombe P, Heggie S, Thorpe K, McElligott C, English G, Henders A, Henderson R, Lomen-Hoerth C, Wray N, McRae A, Pellegrini M, Garton F, Zaitlen N. PMID: 38645132; PMCID: PMC11030489.
      View in: PubMed   Mentions: 1  
    10. Multi-ancestry polygenic mechanisms of type 2 diabetes. Nat Med. 2024 Apr; 30(4):1065-1074. Smith K, Deutsch AJ, McGrail C, Kim H, Hsu S, Huerta-Chagoya A, Mandla R, Schroeder PH, Westerman KE, Szczerbinski L, Majarian TD, Kaur V, Williamson A, Zaitlen N, Claussnitzer M, Florez JC, Manning AK, Mercader JM, Gaulton KJ, Udler MS. PMID: 38443691; PMCID: PMC11175990.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    11. Cell-type deconvolution of bulk-blood RNA-seq reveals biological insights into neuropsychiatric disorders. Am J Hum Genet. 2024 02 01; 111(2):323-337. Boltz T, Schwarz T, Bot M, Hou K, Caggiano C, Lapinska S, Duan C, Boks MP, Kahn RS, Zaitlen N, Pasaniuc B, Ophoff R. PMID: 38306997; PMCID: PMC10870131.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. A comprehensive analysis of clinical and polygenic germline influences on somatic mutational burden. Am J Hum Genet. 2024 02 01; 111(2):242-258. Taraszka K, Groha S, King D, Tell R, White K, Ziv E, Zaitlen N, Gusev A. PMID: 38211585; PMCID: PMC10870141.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    13. A scalable and robust variance components method reveals insights into the architecture of gene-environment interactions underlying complex traits. bioRxiv. 2023 Dec 13. Pazokitoroudi A, Dahl A, Zaitlen N, Rosset S, Sankararaman S. PMID: 38168200; PMCID: PMC10760005.
      View in: PubMed   Mentions:
    14. GCLiPP: global crosslinking and protein purification method for constructing high-resolution occupancy maps for RNA binding proteins. Genome Biol. 2023 12 07; 24(1):281. Zhu WS, Litterman AJ, Sekhon HS, Kageyama R, Arce MM, Taylor KE, Zhao W, Criswell LA, Zaitlen N, Erle DJ, Ansel KM. PMID: 38062486; PMCID: PMC10701951.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    15. Polygenic profiles define aspects of clinical heterogeneity in attention deficit hyperactivity disorder. Nat Genet. 2024 Feb; 56(2):234-244. LaBianca S, Brikell I, Helenius D, Loughnan R, Mefford J, Palmer CE, Walker R, Gådin JR, Krebs M, Appadurai V, Vaez M, Agerbo E, Pedersen MG, Børglum AD, Hougaard DM, Mors O, Nordentoft M, Mortensen PB, Kendler KS, Jernigan TL, Geschwind DH, Ingason A, Dahl AW, Zaitlen N, Dalsgaard S, Werge TM, Schork AJ. PMID: 38036780; PMCID: PMC11439085.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    16. SLIViT: a general AI framework for clinical-feature diagnosis from limited 3D biomedical-imaging data. Res Sq. 2023 Nov 21. Avram O, Durmus B, Rakocz N, Corradetti G, An U, Nitalla MG, Rudas A, Wakatsuki Y, Hirabayashi K, Velaga S, Tiosano L, Corvi F, Verma A, Karamat A, Lindenberg S, Oncel D, Almidani L, Hull V, Fasih-Ahmad S, Esmaeilkhanian H, Wykoff CC, Rahmani E, Arnold CW, Zhou B, Zaitlen N, Gronau I, Sankararaman S, Chiang JN, Sadda SR, Halperin E. PMID: 38045283; PMCID: PMC10690310.
      View in: PubMed   Mentions:
    17. Deep learning-based phenotype imputation on population-scale biobank data increases genetic discoveries. Nat Genet. 2023 Dec; 55(12):2269-2276. An U, Pazokitoroudi A, Alvarez M, Huang L, Bacanu S, Schork AJ, Kendler K, Pajukanta P, Flint J, Zaitlen N, Cai N, Dahl A, Sankararaman S. PMID: 37985819; PMCID: PMC10703681.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    18. Strong Effect of Demographic Changes on Tuberculosis Susceptibility in South Africa. medRxiv. 2023 Nov 03. Oyageshio OP, Myrick JW, Saayman J, van der Westhuizen L, Al-Hindi D, Reynolds AW, Zaitlen N, Uren C, Möller M, Henn BM. PMID: 37961495; PMCID: PMC10635255.
      View in: PubMed   Mentions:
    19. A biobank-scale test of marginal epistasis reveals genome-wide signals of polygenic epistasis. bioRxiv. 2023 Sep 12. Fu B, Pazokitoroudi A, Xue A, Anand A, Anand P, Zaitlen N, Sankararaman S. PMID: 37745394; PMCID: PMC10515811.
      View in: PubMed   Mentions:
    20. Genotype error due to low-coverage sequencing induces uncertainty in polygenic scoring. Am J Hum Genet. 2023 08 03; 110(8):1319-1329. Petter E, Ding Y, Hou K, Bhattacharya A, Gusev A, Zaitlen N, Pasaniuc B. PMID: 37490908; PMCID: PMC10432141.
      View in: PubMed   Mentions: 1     Fields:    
    21. Disease risk and healthcare utilization among ancestrally diverse groups in the Los Angeles region. Nat Med. 2023 07; 29(7):1845-1856. Caggiano C, Boudaie A, Shemirani R, Mefford J, Petter E, Chiu A, Ercelen D, He R, Tward D, Paul KC, Chang TS, Pasaniuc B, Kenny EE, Shortt JA, Gignoux CR, Balliu B, Arboleda VA, Belbin G, Zaitlen N. PMID: 37464048; PMCID: PMC11121511.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    22. Gene expression in African Americans, Puerto Ricans and Mexican Americans reveals ancestry-specific patterns of genetic architecture. Nat Genet. 2023 06; 55(6):952-963. Kachuri L, Mak ACY, Hu D, Eng C, Huntsman S, Elhawary JR, Gupta N, Gabriel S, Xiao S, Keys KL, Oni-Orisan A, Rodríguez-Santana JR, LeNoir MA, Borrell LN, Zaitlen NA, Williams LK, Gignoux CR, Burchard EG, Ziv E. PMID: 37231098; PMCID: PMC10260401.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    23. Cell type deconvolution of bulk blood RNA-Seq to reveal biological insights of neuropsychiatric disorders. bioRxiv. 2023 May 25. Boltz T, Schwarz T, Bot M, Hou K, Caggiano C, Lapinska S, Duan C, Boks MP, Kahn RS, Zaitlen N, Pasaniuc B, Ophoff R. PMID: 37293101; PMCID: PMC10245943.
      View in: PubMed   Mentions:
    24. Effect of statins on the age of onset of age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol. 2023 Aug; 261(8):2245-2255. Ganesh D, Chiang JN, Corradetti G, Zaitlen N, Halperin E, Sadda SR. PMID: 36917316.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. Multi-omic approach associates blood methylome with bronchodilator drug response in pediatric asthma. J Allergy Clin Immunol. 2023 06; 151(6):1503-1512. Perez-Garcia J, Herrera-Luis E, Li A, Mak ACY, Huntsman S, Oh SS, Elhawary JR, Eng C, Beckman KB, Hu D, Lorenzo-Diaz F, Lenoir MA, Rodriguez-Santana J, Zaitlen N, Villar J, Borrell LN, Burchard EG, Pino-Yanes M. PMID: 36796456.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    26. Phenotypic subtyping via contrastive learning. bioRxiv. 2023 Jan 06. Gorla A, Sankararaman S, Burchard E, Flint J, Zaitlen N, Rahmani E. PMID: 36711575; PMCID: PMC9881932.
      View in: PubMed   Mentions:
    27. Cross-trait assortative mating is widespread and inflates genetic correlation estimates. Science. 2022 11 18; 378(6621):754-761. Border R, Athanasiadis G, Buil A, Schork AJ, Cai N, Young AI, Werge T, Flint J, Kendler KS, Sankararaman S, Dahl AW, Zaitlen NA. PMID: 36395242; PMCID: PMC9901291.
      View in: PubMed   Mentions: 59     Fields:    Translation:Humans
    28. Author Correction: Leveraging genomic diversity for discovery in an electronic health record linked biobank: the UCLA ATLAS Community Health Initiative. Genome Med. 2022 Nov 16; 14(1):128. Johnson R, Ding Y, Venkateswaran V, Bhattacharya A, Boulier K, Chiu A, Knyazev S, Schwarz T, Freund M, Zhan L, Burch KS, Caggiano C, Hill B, Rakocz N, Balliu B, Denny CT, Sul JH, Zaitlen N, Arboleda VA, Halperin E, Sankararaman S, Butte MJ, UCLA Precision Health Data Discovery Repository Working Group, UCLA Precision Health ATLAS Working G, Lajonchere C, Geschwind DH, Pasaniuc B. PMID: 36384576; PMCID: PMC9670414.
      View in: PubMed   Mentions:    Fields:    
    29. Leveraging pleiotropy for joint analysis of genome-wide association studies with per trait interpretations. PLoS Genet. 2022 11; 18(11):e1010447. Taraszka K, Zaitlen N, Eskin E. PMID: 36342933; PMCID: PMC9671458.
      View in: PubMed   Mentions: 3     Fields:    
    30. Author Correction: Nasal airway transcriptome-wide association study of asthma reveals genetically driven mucus pathobiology. Nat Commun. 2022 Oct 03; 13(1):5806. Sajuthi SP, Everman JL, Jackson ND, Saef B, Rios CL, Moore CM, Mak ACY, Eng C, Fairbanks-Mahnke A, Salazar S, Elhawary J, Huntsman S, Medina V, Nickerson DA, Germer S, Zody MC, Abecasis G, Kang HM, Rice KM, Kumar R, Zaitlen NA, Oh S, NHLBI Trans–Omics for Precision Medicine (TOPMed) Consortium, Rodríguez-Santana J, Burchard EG, Seibold MA. PMID: 36192399; PMCID: PMC9530212.
      View in: PubMed   Mentions:    Fields:    
    31. Ancestry-driven recalibration of tumor mutational burden and disparate clinical outcomes in response to immune checkpoint inhibitors. Cancer Cell. 2022 10 10; 40(10):1161-1172.e5. Nassar AH, Adib E, Abou Alaiwi S, El Zarif T, Groha S, Akl EW, Nuzzo PV, Mouhieddine TH, Perea-Chamblee T, Taraszka K, El-Khoury H, Labban M, Fong C, Arora KS, Labaki C, Xu W, Sonpavde G, Haddad RI, Mouw KW, Giannakis M, Hodi FS, Zaitlen N, Schoenfeld AJ, Schultz N, Berger MF, MacConaill LE, Ananda G, Kwiatkowski DJ, Choueiri TK, Schrag D, Carrot-Zhang J, Gusev A. PMID: 36179682; PMCID: PMC9559771.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    32. Multi-context genetic modeling of transcriptional regulation resolves novel disease loci. Nat Commun. 2022 09 28; 13(1):5704. Thompson M, Gordon MG, Lu A, Tandon A, Halperin E, Gusev A, Ye CJ, Balliu B, Zaitlen N. PMID: 36171194; PMCID: PMC9519579.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    33. Leveraging genomic diversity for discovery in an electronic health record linked biobank: the UCLA ATLAS Community Health Initiative. Genome Med. 2022 Sep 09; 14(1):104. Johnson R, Ding Y, Venkateswaran V, Bhattacharya A, Boulier K, Chiu A, Knyazev S, Schwarz T, Freund M, Zhan L, Burch KS, Caggiano C, Hill B, Rakocz N, Balliu B, Denny CT, Sul JH, Zaitlen N, Arboleda VA, Halperin E, Sankararaman S, Butte MJ, UCLA Precision Health Data Discovery Repository Working Group, UCLA Precision Health ATLAS Working G, Lajonchere C, Geschwind DH, Pasaniuc B. PMID: 36085083; PMCID: PMC9461263.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansPHPublic Health
    34. Methylation risk scores are associated with a collection of phenotypes within electronic health record systems. NPJ Genom Med. 2022 Aug 25; 7(1):50. Thompson M, Hill BL, Rakocz N, Chiang JN, Geschwind D, Sankararaman S, Hofer I, Cannesson M, Zaitlen N, Halperin E. PMID: 36008412; PMCID: PMC9411568.
      View in: PubMed   Mentions: 26  
    35. Single-cell RNA-seq reveals cell type-specific molecular and genetic associations to lupus. Science. 2022 04 08; 376(6589):eabf1970. Perez RK, Gordon MG, Subramaniam M, Kim MC, Hartoularos GC, Targ S, Sun Y, Ogorodnikov A, Bueno R, Lu A, Thompson M, Rappoport N, Dahl A, Lanata CM, Matloubian M, Maliskova L, Kwek SS, Li T, Slyper M, Waldman J, Dionne D, Rozenblatt-Rosen O, Fong L, Dall'Era M, Balliu B, Regev A, Yazdany J, Criswell LA, Zaitlen N, Ye CJ. PMID: 35389781; PMCID: PMC9297655.
      View in: PubMed   Mentions: 129     Fields:    Translation:HumansCells
    36. Nasal airway transcriptome-wide association study of asthma reveals genetically driven mucus pathobiology. Nat Commun. 2022 03 28; 13(1):1632. Sajuthi SP, Everman JL, Jackson ND, Saef B, Rios CL, Moore CM, Mak ACY, Eng C, Fairbanks-Mahnke A, Salazar S, Elhawary J, Huntsman S, Medina V, Nickerson DA, Germer S, Zody MC, Abecasis G, Kang HM, Rice KM, Kumar R, Zaitlen NA, Oh S, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Rodríguez-Santana J, Burchard EG, Seibold MA. PMID: 35347136; PMCID: PMC8960819.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    37. Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1. Genome Med. 2022 01 19; 14(1):7. Restuadi R, Steyn FJ, Kabashi E, Ngo ST, Cheng FF, Nabais MF, Thompson MJ, Qi T, Wu Y, Henders AK, Wallace L, Bye CR, Turner BJ, Ziser L, Mathers S, McCombe PA, Needham M, Schultz D, Kiernan MC, van Rheenen W, van den Berg LH, Veldink JH, Ophoff R, Gusev A, Zaitlen N, McRae AF, Henderson RD, Wray NR, Giacomotto J, Garton FC. PMID: 35042540; PMCID: PMC8767698.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    38. Massively parallel analysis of human 3' UTRs reveals that AU-rich element length and registration predict mRNA destabilization. G3 (Bethesda). 2022 01 04; 12(1). Siegel DA, Le Tonqueze O, Biton A, Zaitlen N, Erle DJ. PMID: 34849835; PMCID: PMC8728028.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    39. Constructing germline research cohorts from the discarded reads of clinical tumor sequences. Genome Med. 2021 11 08; 13(1):179. Gusev A, Groha S, Taraszka K, Semenov YR, Zaitlen N. PMID: 34749793; PMCID: PMC8576948.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    40. Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes. Nat Commun. 2021 06 09; 12(1):3505. Goodrich JK, Singer-Berk M, Son R, Sveden A, Wood J, England E, Cole JB, Weisburd B, Watts N, Caulkins L, Dornbos P, Koesterer R, Zappala Z, Zhang H, Maloney KA, Dahl A, Aguilar-Salinas CA, Atzmon G, Barajas-Olmos F, Barzilai N, Blangero J, Boerwinkle E, Bonnycastle LL, Bottinger E, Bowden DW, Centeno-Cruz F, Chambers JC, Chami N, Chan E, Chan J, Cheng CY, Cho YS, Contreras-Cubas C, Córdova E, Correa A, DeFronzo RA, Duggirala R, Dupuis J, Garay-Sevilla ME, García-Ortiz H, Gieger C, Glaser B, González-Villalpando C, Gonzalez ME, Grarup N, Groop L, Gross M, Haiman C, Han S, Hanis CL, Hansen T, Heard-Costa NL, Henderson BE, Hernandez JMM, Hwang MY, Islas-Andrade S, Jørgensen ME, Kang HM, Kim BJ, Kim YJ, Koistinen HA, Kooner JS, Kuusisto J, Kwak SH, Laakso M, Lange L, Lee JY, Lee J, Lehman DM, Linneberg A, Liu J, Loos RJF, Lyssenko V, Ma RCW, Martínez-Hernández A, Meigs JB, Meitinger T, Mendoza-Caamal E, Mohlke KL, Morris AD, Morrison AC, Ng MCY, Nilsson PM, O'Donnell CJ, Orozco L, Palmer CNA, Park KS, Post WS, Pedersen O, Preuss M, Psaty BM, Reiner AP, Revilla-Monsalve C, Rich SS, Rotter JI, Saleheen D, Schurmann C, Sim X, Sladek R, Small KS, So WY, Spector TD, Strauch K, Strom TM, Tai ES, Tam CHT, Teo YY, Thameem F, Tomlinson B, Tracy RP, Tuomi T, Tuomilehto J, Tusié-Luna T, van Dam RM, Vasan RS, Wilson JG, Witte DR, Wong TY, AMP-T2D-GENES Consortia, Burtt NP, Zaitlen N, McCarthy MI, Boehnke M, Pollin TI, Flannick J, Mercader JM, O'Donnell-Luria A, Baxter S, Florez JC, MacArthur DG, Udler MS. PMID: 34108472; PMCID: PMC8190084.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    41. Admixed Populations Improve Power for Variant Discovery and Portability in Genome-Wide Association Studies. Front Genet. 2021; 12:673167. Lin M, Park DS, Zaitlen NA, Henn BM, Gignoux CR. PMID: 34108994; PMCID: PMC8181458.
      View in: PubMed   Mentions: 15  
    42. Comprehensive cell type decomposition of circulating cell-free DNA with CelFiE. Nat Commun. 2021 05 11; 12(1):2717. Caggiano C, Celona B, Garton F, Mefford J, Black BL, Henderson R, Lomen-Hoerth C, Dahl A, Zaitlen N. PMID: 33976150; PMCID: PMC8113516.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    43. Toward a fine-scale population health monitoring system. Cell. 2021 04 15; 184(8):2068-2083.e11. Belbin GM, Cullina S, Wenric S, Soper ER, Glicksberg BS, Torre D, Moscati A, Wojcik GL, Shemirani R, Beckmann ND, Cohain A, Sorokin EP, Park DS, Ambite JL, Ellis S, Auton A, CBIPM Genomics Team, Regeneron Genetics Center, Bottinger EP, Cho JH, Loos RJF, Abul-Husn NS, Zaitlen NA, Gignoux CR, Kenny EE. PMID: 33861964.
      View in: PubMed   Mentions: 60     Fields:    Translation:Humans
    44. A model and test for coordinated polygenic epistasis in complex traits. Proc Natl Acad Sci U S A. 2021 04 13; 118(15). Sheppard B, Rappoport N, Loh PR, Sanders SJ, Zaitlen N, Dahl A. PMID: 33833052; PMCID: PMC8053945.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    45. Disentangling selection on genetically correlated polygenic traits via whole-genome genealogies. Am J Hum Genet. 2021 02 04; 108(2):219-239. Stern AJ, Speidel L, Zaitlen NA, Nielsen R. PMID: 33440170; PMCID: PMC7895848.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    46. Race and Genetic Ancestry in Medicine - A Time for Reckoning with Racism. N Engl J Med. 2021 Feb 04; 384(5):474-480. Borrell LN, Elhawary JR, Fuentes-Afflick E, Witonsky J, Bhakta N, Wu AHB, Bibbins-Domingo K, Rodríguez-Santana JR, Lenoir MA, Gavin JR, Kittles RA, Zaitlen NA, Wilkes DS, Powe NR, Ziv E, Burchard EG. PMID: 33406325; PMCID: PMC8979367.
      View in: PubMed   Mentions: 245     Fields:    Translation:Humans
    47. Author Correction: Multiplexed droplet single-cell RNA-sequencing using natural genetic variation. Nat Biotechnol. 2020 Nov; 38(11):1356. Kang HM, Subramaniam M, Targ S, Nguyen M, Maliskova L, McCarthy E, Wan E, Wong S, Byrnes L, Lanata CM, Gate RE, Mostafavi S, Marson A, Zaitlen N, Criswell LA, Ye CJ. PMID: 33057163.
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    105. Leveraging population admixture to characterize the heritability of complex traits. Nat Genet. 2014 Dec; 46(12):1356-62. Zaitlen N, Pasaniuc B, Sankararaman S, Bhatia G, Zhang J, Gusev A, Young T, Tandon A, Pollack S, Vilhjálmsson BJ, Assimes TL, Berndt SI, Blot WJ, Chanock S, Franceschini N, Goodman PG, He J, Hennis AJ, Hsing A, Ingles SA, Isaacs W, Kittles RA, Klein EA, Lange LA, Nemesure B, Patterson N, Reich D, Rybicki BA, Stanford JL, Stevens VL, Strom SS, Whitsel EA, Witte JS, Xu J, Haiman C, Wilson JG, Kooperberg C, Stram D, Reiner AP, Tang H, Price AL. PMID: 25383972; PMCID: PMC4244251.
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    106. Intersection of population variation and autoimmunity genetics in human T cell activation. Science. 2014 Sep 12; 345(6202):1254665. Ye CJ, Feng T, Kwon HK, Raj T, Wilson MT, Asinovski N, McCabe C, Lee MH, Frohlich I, Paik HI, Zaitlen N, Hacohen N, Stranger B, De Jager P, Mathis D, Regev A, Benoist C. PMID: 25214635; PMCID: PMC4751028.
      View in: PubMed   Mentions: 140     Fields:    Translation:HumansCells
    107. Fast and accurate imputation of summary statistics enhances evidence of functional enrichment. Bioinformatics. 2014 Oct 15; 30(20):2906-14. Pasaniuc B, Zaitlen N, Shi H, Bhatia G, Gusev A, Pickrell J, Hirschhorn J, Strachan DP, Patterson N, Price AL. PMID: 24990607; PMCID: PMC4184260.
      View in: PubMed   Mentions: 103     Fields:    Translation:Humans
    108. Massively parallel functional annotation of 3' untranslated regions. Nat Biotechnol. 2014 Apr; 32(4):387-91. Zhao W, Pollack JL, Blagev DP, Zaitlen N, McManus MT, Erle DJ. PMID: 24633241; PMCID: PMC3981918.
      View in: PubMed   Mentions: 69     Fields:    Translation:Humans
    109. Advantages and pitfalls in the application of mixed-model association methods. Nat Genet. 2014 Feb; 46(2):100-6. Yang J, Zaitlen NA, Goddard ME, Visscher PM, Price AL. PMID: 24473328; PMCID: PMC3989144.
      View in: PubMed   Mentions: 456     Fields:    Translation:Humans
    110. Quantifying missing heritability at known GWAS loci. PLoS Genet. 2013; 9(12):e1003993. Gusev A, Bhatia G, Zaitlen N, Vilhjalmsson BJ, Diogo D, Stahl EA, Gregersen PK, Worthington J, Klareskog L, Raychaudhuri S, Plenge RM, Pasaniuc B, Price AL. PMID: 24385918; PMCID: PMC3873246.
      View in: PubMed   Mentions: 66     Fields:    Translation:Humans
    111. Genome-wide association study of ancestry-specific TB risk in the South African Coloured population. Hum Mol Genet. 2014 Feb 01; 23(3):796-809. Chimusa ER, Zaitlen N, Daya M, Möller M, van Helden PD, Mulder NJ, Price AL, Hoal EG. PMID: 24057671; PMCID: PMC3888262.
      View in: PubMed   Mentions: 96     Fields:    Translation:Humans
    112. Using extended genealogy to estimate components of heritability for 23 quantitative and dichotomous traits. PLoS Genet. 2013 May; 9(5):e1003520. Zaitlen N, Kraft P, Patterson N, Pasaniuc B, Bhatia G, Pollack S, Price AL. PMID: 23737753; PMCID: PMC3667752.
      View in: PubMed   Mentions: 203     Fields:    Translation:Humans
    113. Analysis of Latino populations from GALA and MEC studies reveals genomic loci with biased local ancestry estimation. Bioinformatics. 2013 Jun 01; 29(11):1407-15. Pasaniuc B, Sankararaman S, Torgerson DG, Gignoux C, Zaitlen N, Eng C, Rodriguez-Cintron W, Chapela R, Ford JG, Avila PC, Rodriguez-Santana J, Chen GK, Le Marchand L, Henderson B, Reich D, Haiman CA, Gonzàlez Burchard E, Halperin E. PMID: 23572411; PMCID: PMC3661056.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    114. A nonparametric test to detect quantitative trait loci where the phenotypic distribution differs by genotypes. Genet Epidemiol. 2013 May; 37(4):323-33. Aschard H, Zaitlen N, Tamimi RM, Lindström S, Kraft P. PMID: 23512279; PMCID: PMC4088942.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    115. Response to Sul and Eskin. Nat Rev Genet. 2013 Apr; 14(4):300. Price AL, Zaitlen NA, Reich D, Patterson N. PMID: 23438870; PMCID: PMC5586503.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    116. Informed conditioning on clinical covariates increases power in case-control association studies. PLoS Genet. 2012; 8(11):e1003032. Zaitlen N, Lindström S, Pasaniuc B, Cornelis M, Genovese G, Pollack S, Barton A, Bickeböller H, Bowden DW, Eyre S, Freedman BI, Friedman DJ, Field JK, Groop L, Haugen A, Heinrich J, Henderson BE, Hicks PJ, Hocking LJ, Kolonel LN, Landi MT, Langefeld CD, Le Marchand L, Meister M, Morgan AW, Raji OY, Risch A, Rosenberger A, Scherf D, Steer S, Walshaw M, Waters KM, Wilson AG, Wordsworth P, Zienolddiny S, Tchetgen ET, Haiman C, Hunter DJ, Plenge RM, Worthington J, Christiani DC, Schaumberg DA, Chasman DI, Altshuler D, Voight B, Kraft P, Patterson N, Price AL. PMID: 23144628; PMCID: PMC3493452.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    117. Heritability in the genome-wide association era. Hum Genet. 2012 Oct; 131(10):1655-64. Zaitlen N, Kraft P. PMID: 22821350; PMCID: PMC3432754.
      View in: PubMed   Mentions: 92     Fields:    Translation:Humans
    118. Extremely low-coverage sequencing and imputation increases power for genome-wide association studies. Nat Genet. 2012 May 20; 44(6):631-5. Pasaniuc B, Rohland N, McLaren PJ, Garimella K, Zaitlen N, Li H, Gupta N, Neale BM, Daly MJ, Sklar P, Sullivan PF, Bergen S, Moran JL, Hultman CM, Lichtenstein P, Magnusson P, Purcell SM, Haas DW, Liang L, Sunyaev S, Patterson N, de Bakker PI, Reich D, Price AL. PMID: 22610117; PMCID: PMC3400344.
      View in: PubMed   Mentions: 144     Fields:    Translation:Humans
    119. Analysis of case-control association studies with known risk variants. Bioinformatics. 2012 Jul 01; 28(13):1729-37. Zaitlen N, Pasaniuc B, Patterson N, Pollack S, Voight B, Groop L, Altshuler D, Henderson BE, Kolonel LN, Le Marchand L, Waters K, Haiman CA, Stranger BE, Dermitzakis ET, Kraft P, Price AL. PMID: 22556366; PMCID: PMC3381970.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    120. Combining effects from rare and common genetic variants in an exome-wide association study of sequence data. BMC Proc. 2011 Nov 29; 5 Suppl 9:S44. Aschard H, Qiu W, Pasaniuc B, Zaitlen N, Cho MH, Carey V. PMID: 22373328; PMCID: PMC3287881.
      View in: PubMed   Mentions: 2  
    121. Genome-wide comparison of African-ancestry populations from CARe and other cohorts reveals signals of natural selection. Am J Hum Genet. 2011 Sep 09; 89(3):368-81. Bhatia G, Patterson N, Pasaniuc B, Zaitlen N, Genovese G, Pollack S, Mallick S, Myers S, Tandon A, Spencer C, Palmer CD, Adeyemo AA, Akylbekova EL, Cupples LA, Divers J, Fornage M, Kao WH, Lange L, Li M, Musani S, Mychaleckyj JC, Ogunniyi A, Papanicolaou G, Rotimi CN, Rotter JI, Ruczinski I, Salako B, Siscovick DS, Tayo BO, Yang Q, McCarroll S, Sabeti P, Lettre G, De Jager P, Hirschhorn J, Zhu X, Cooper R, Reich D, Wilson JG, Price AL. PMID: 21907010; PMCID: PMC3169818.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    122. Genotyping common and rare variation using overlapping pool sequencing. BMC Bioinformatics. 2011; 12 Suppl 6:S2. He D, Zaitlen N, Pasaniuc B, Eskin E, Halperin E. PMID: 21989232; PMCID: PMC3194190.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    123. Enhanced statistical tests for GWAS in admixed populations: assessment using African Americans from CARe and a Breast Cancer Consortium. PLoS Genet. 2011 Apr; 7(4):e1001371. Pasaniuc B, Zaitlen N, Lettre G, Chen GK, Tandon A, Kao WH, Ruczinski I, Fornage M, Siscovick DS, Zhu X, Larkin E, Lange LA, Cupples LA, Yang Q, Akylbekova EL, Musani SK, Divers J, Mychaleckyj J, Li M, Papanicolaou GJ, Millikan RC, Ambrosone CB, John EM, Bernstein L, Zheng W, Hu JJ, Ziegler RG, Nyante SJ, Bandera EV, Ingles SA, Press MF, Chanock SJ, Deming SL, Rodriguez-Gil JL, Palmer CD, Buxbaum S, Ekunwe L, Hirschhorn JN, Henderson BE, Myers S, Haiman CA, Reich D, Patterson N, Wilson JG, Price AL. PMID: 21541012; PMCID: PMC3080860.
      View in: PubMed   Mentions: 82     Fields:    Translation:Humans
    124. Accurate estimation of expression levels of homologous genes in RNA-seq experiments. J Comput Biol. 2011 Mar; 18(3):459-68. Pasaniuc B, Zaitlen N, Halperin E. PMID: 21385047.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    125. Imputation aware meta-analysis of genome-wide association studies. Genet Epidemiol. 2010 Sep; 34(6):537-42. Zaitlen N, Eskin E. PMID: 20717975; PMCID: PMC3102182.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    126. Multi-marker tagging single nucleotide polymorphism selection using estimation of distribution algorithms. Artif Intell Med. 2010 Nov; 50(3):193-201. Santana R, Mendiburu A, Zaitlen N, Eskin E, Lozano JA. PMID: 20650616.
      View in: PubMed   Mentions: 2     Fields:    
    127. New approaches to population stratification in genome-wide association studies. Nat Rev Genet. 2010 Jul; 11(7):459-63. Price AL, Zaitlen NA, Reich D, Patterson N. PMID: 20548291; PMCID: PMC2975875.
      View in: PubMed   Mentions: 584     Fields:    Translation:Humans
    128. Variance component model to account for sample structure in genome-wide association studies. Nat Genet. 2010 Apr; 42(4):348-54. Kang HM, Sul JH, Service SK, Zaitlen NA, Kong SY, Freimer NB, Sabatti C, Eskin E. PMID: 20208533; PMCID: PMC3092069.
      View in: PubMed   Mentions: 1406     Fields:    Translation:Humans
    129. EMINIM: an adaptive and memory-efficient algorithm for genotype imputation. J Comput Biol. 2010 Mar; 17(3):547-60. Kang HM, Zaitlen NA, Eskin E. PMID: 20377463; PMCID: PMC3198882.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    130. Leveraging genetic variability across populations for the identification of causal variants. Am J Hum Genet. 2010 Jan; 86(1):23-33. Zaitlen N, Pasaniuc B, Gur T, Ziv E, Halperin E. PMID: 20085711; PMCID: PMC2801753.
      View in: PubMed   Mentions: 96     Fields:    Translation:Humans
    131. Genome-wide association study of bipolar disorder in European American and African American individuals. Mol Psychiatry. 2009 Aug; 14(8):755-63. Smith EN, Bloss CS, Badner JA, Barrett T, Belmonte PL, Berrettini W, Byerley W, Coryell W, Craig D, Edenberg HJ, Eskin E, Foroud T, Gershon E, Greenwood TA, Hipolito M, Koller DL, Lawson WB, Liu C, Lohoff F, McInnis MG, McMahon FJ, Mirel DB, Murray SS, Nievergelt C, Nurnberger J, Nwulia EA, Paschall J, Potash JB, Rice J, Schulze TG, Scheftner W, Panganiban C, Zaitlen N, Zandi PP, Zöllner S, Schork NJ, Kelsoe JR. PMID: 19488044; PMCID: PMC3035981.
      View in: PubMed   Mentions: 198     Fields:    Translation:Humans
    132. Linkage effects and analysis of finite sample errors in the HapMap. Hum Hered. 2009; 68(2):73-86. Zaitlen N, Kang HM, Eskin E. PMID: 19365134; PMCID: PMC2874737.
      View in: PubMed   Mentions: 4     Fields:    
    133. Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet. 2009 Jan; 41(1):35-46. Sabatti C, Service SK, Hartikainen AL, Pouta A, Ripatti S, Brodsky J, Jones CG, Zaitlen NA, Varilo T, Kaakinen M, Sovio U, Ruokonen A, Laitinen J, Jakkula E, Coin L, Hoggart C, Collins A, Turunen H, Gabriel S, Elliot P, McCarthy MI, Daly MJ, Järvelin MR, Freimer NB, Peltonen L. PMID: 19060910; PMCID: PMC2687077.
      View in: PubMed   Mentions: 410     Fields:    Translation:Humans
    134. Shift-invariant adaptive double threading: learning MHC II-peptide binding. J Comput Biol. 2008 Sep; 15(7):927-42. Zaitlen N, Reyes-Gomez M, Heckerman D, Jojic N. PMID: 18771399.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    135. Efficient association study design via power-optimized tag SNP selection. Ann Hum Genet. 2008 Nov; 72(Pt 6):834-47. Han B, Kang HM, Seo MS, Zaitlen N, Eskin E. PMID: 18702637; PMCID: PMC2574965.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    136. Efficient control of population structure in model organism association mapping. Genetics. 2008 Mar; 178(3):1709-23. Kang HM, Zaitlen NA, Wade CM, Kirby A, Heckerman D, Daly MJ, Eskin E. PMID: 18385116; PMCID: PMC2278096.
      View in: PubMed   Mentions: 841     Fields:    Translation:Animals
    137. Leveraging the HapMap correlation structure in association studies. Am J Hum Genet. 2007 Apr; 80(4):683-91. Zaitlen N, Kang HM, Eskin E, Halperin E. PMID: 17357074; PMCID: PMC1852710.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    138. Inference and analysis of haplotypes from combined genotyping studies deposited in dbSNP. Genome Res. 2005 Nov; 15(11):1594-600. Zaitlen NA, Kang HM, Feolo ML, Sherry ST, Halperin E, Eskin E. PMID: 16251470; PMCID: PMC1310648.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
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