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David T Wong

Photo of David T Wong
Title(s)Professor, Dentistry Dept.
SchoolDentistry
ORCID ORCID Icon0000-0002-0290-2206 Additional info
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    Other Positions
    Title(s)Professor, Head and Neck Surgery


    Collapse Biography 
    Collapse education and training
    Simon Fraser University , Burnaby, British Columbia, CanadaBSc06/1977Biochemistry
    University of British Columbia, Vancouver, British ColumbiaDMD06/1981Dental Medicine
    Harvard Medical School, Boston, Massachusetts, USADMSc06/1985Molecular Biology
    Harvard School of Dental Medicine, Boston, Massachusetts, USACertificate06/1985Oral Pathology

    Collapse Overview 
    Collapse overview
    1. My laboratory spearheads the use of genome-wide and proteome-wide high-throughput technologies to harness the diagnostic and biological determinants pertaining to the pathogenesis of oral/head and neck cancer. In particular we are focusing on the genomic and proteomic determinants of oral cancer progression. Using a patient-based genome/proteome-wide approach; we are harnessing the genomic and proteomic determinants that distinguish progressing from non-progression oral precancers. For genomic defects, a concurrent approach to identify gene copy number abnormalities (CNA) by cDNA microarray comparative genomic hybridization (CGH) as well as SNP-based loss of heterozygosity (LOH) using the Affymetrix 100K SNP-based Mapping Arrays. For expression analysis, the Affymetrix 133+ 2 and all exon high-density oligonucleotide arrays are used. For proteomic analysis, LC-MS/MS as well as single cell proteomics are creatively being integrated. A key component to a systems approach (Weighted-Gene Co-Expression Network Analysis, WGCNA) is to seek out molecular concordance of detectable molecular defects.

    a. Das S, Ansel KM, Bitzer M, Breakefield XO, Charest A, Galas DJ, Gerstein MB, Gupta M, Milosavljevic A, McManus MT, Patel T, Raffai RL, Rozowsky J, Roth ME, Saugstad JA, Van Keuren-Jensen K, Weaver AM, Laurent LC. The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research. Cell. 2019 Apr 4;177(2):231-242. PubMed Central PMCID: PMC6601620.
    b. Yu T, Ye H, Sun W, Li KC, Chen Z, Jacobs S, Bailey DK, Wong DT, Zhou X. A forward-backward fragment assembling algorithm for the identification of genomic amplification and deletion breakpoints using high-density single nucleotide polymorphism (SNP) array. BMC Bioinformatics. 2007 May 3;8:145. PubMed Central PMCID: PMC1868765.
    c. Zhou X, Temam S, Chen Z, Ye H, Mao L, Wong DT. Allelic imbalance analysis of oral tongue squamous cell carcinoma by high-density single nucleotide polymorphism arrays using whole-genome amplified DNA. Hum Genet. 2005 Dec;118(3-4):504-7. PubMed PMID: 16193324.
    d. Zhou X, Mok SC, Chen Z, Li Y, Wong DT. Concurrent analysis of loss of heterozygosity (LOH) and copy number abnormality (CNA) for oral premalignancy progression using the Affymetrix 10K SNP mapping array. Hum Genet. 2004 Sep;115(4):327-30. PubMed PMID: 15290239.

    2. We subscribe to the belief that a central defect in human cancer lies in the dysregulation of cell cycle control. Establishing a molecular database of cell cycle regulatory genes dysregulated in head and neck cancer and understanding the molecular and biochemical pathways of these genes are areas of prime interest. Using differential expression screening assays we have identified a number of cellular genes that are differentially expressed in squamous cell carcinoma. CDK2-AP1 is a differentially expressed cellular gene that is currently being studied. CDK2-AP1 is a novel gene exhibiting growth suppressor properties. CDK2-AP1 exerts its growth suppressor function by negatively regulating the activities of DNA polymerase- /primase and cyclin-dependent kinase 2 (CDK2). CDK2-AP1 associates with DNA polymerase-/primase suppressing DNA replication, affecting predominantly the initiation step. CDK2-AP1 has been found to associates with the monomeric non-phosphorylated form of CDK2, suppressing CDK2-associated kinase activities and cell cycle progression. CDK2-AP1 also targets CDK2 for proteolysis. We are investigating the detailed biochemical and genetic mechanisms of CDK2-AP1 in cell cycle regulation, normal development and carcinogenesis. The recent excitement of this research includes finding that CDK2-AP1 -nulled mice are embryonically lethal and that CDK2-AP1 is an epigenetic regulator for differentiation competency for mouse embryonic stem cells, placing this gene at a pivotal juncture of stem cell differentiation and development.

    a. Kim JJ, Khalid O, Vo S, Sun HH, Wong DT, Kim Y. A novel regulatory factor recruits the nucleosome remodeling complex to wingless integrated (Wnt) signaling gene promoters in mouse embryonic stem cells. J Biol Chem. 2012 Nov 30;287(49):41103-17. PubMed Central PMCID: PMC3510811.
    b. Kim Y, Deshpande A, Dai Y, Kim JJ, Lindgren A, Conway A, Clark AT, Wong DT. Cyclin-dependent kinase 2-associating protein 1 commits murine embryonic stem cell differentiation through retinoblastoma protein regulation. J Biol Chem. 2009 Aug 28;284(35):23405-14. PubMed Central PMCID: PMC2749114.
    c. Deshpande AM, Dai YS, Kim Y, Kim J, Kimlin L, Gao K, Wong DT. Cdk2ap1 is required for epigenetic silencing of Oct4 during murine embryonic stem cell differentiation. J Biol Chem. 2009 Mar 6;284(10):6043-7. PubMed Central PMCID: PMC2649091.
    d. Shintani S, Ohyama H, Zhang X, McBride J, Matsuo K, Tsuji T, Hu MG, Hu G, Kohno Y, Lerman M, Todd R, Wong DT. p12(DOC-1) is a novel cyclin-dependent kinase 2-associated protein. Mol Cell Biol. 2000 Sep;20(17):6300-7. PubMed Central PMCID: PMC86104.

    3. The early detection of cancer by non-invasive means has been the holy grail for cancer researchers. My research group has been spearheading a series of concerted efforts to spearhead the scientific and translational frontiers of salivary diagnostics. The use of saliva, a non-invasive biofluid, for oral and systemic disease detection, for disease progression, and for therapeutic monitoring are highly desirable goals. We have harnessed and defined five diagnostic alphabets from human saliva: salivary proteome, transcriptome, micro-RNA, metabolome and microbiome. The availability of these diagnostic alphabets greatly enhanced the translational utilities of saliva. In parallel to the biomarker efforts, point-of-care technologies are being developed for clinical applications. The “Oral Fluid NanoSensor Test (OFNASET)” is a prototype nanotechnology-based point-of-care sensor that will have the ability to detect multiplex analytes in saliva for disease detection. Two additional highly impactful outcomes emerged from these initiatives. One is the discovery of salivary extracellular RNA in saliva, including a previously unnoticed landscape of non-coding RNA. This project by the NIH Common Fund on “Extracellular RNA Communication Consortium” opened a new horizon of saliva biology. A second facet of excitement is the finding that saliva is an optimal biofluid for liquid biopsy (saliva liquid biopsy, sLB) for detection of actionable mutations in human cancers. Using an electrochemical technology called electric field-induced release and measurement (EFIRM), circulating tumor DNA (ctDNA) was detectable in lung cancer patients with near perfect concordance with tissue based biopsy genotyping.

    a. Murillo OD, Thistlethwaite W, Rozowsky J, Subramanian SL, Lucero R, Shah N, Jackson AR, Srinivasan S, Chung A, Laurent CD, Kitchen RR, Galeev T, Warrell J, Diao JA, Welsh JA, Hanspers K, Riutta A, Burgstaller-Muehlbacher S, Shah RV, Yeri A, Jenkins LM, Ahsen ME, Cordon-Cardo C, Dogra N, Gifford SM, Smith JT, Stolovitzky G, Tewari AK, Wunsch BH, Yadav KK, Danielson KM, Filant J, Moeller C, Nejad P, Paul A, Simonson B, Wong DK, Zhang X, Balaj L, Gandhi R, Sood AK, Alexander RP, Wang L, Wu C, Wong DTW, Galas DJ, Van Keuren-Jensen K, Patel T, Jones JC, Das S, Cheung KH, Pico AR, Su AI, Raffai RL, Laurent LC, Roth ME, Gerstein MB, Milosavljevic A. exRNA Atlas Analysis Reveals Distinct Extracellular RNA Cargo Types and Their Carriers Present across Human Biofluids. Cell. 2019 Apr 4;177(2):463-477.e15. PubMed Central PMCID: PMC6616370.
    b. Wei F, Lin CC, Joon A, Feng Z, Troche G, Lira ME, Chia D, Mao M, Ho CL, Su WC, Wong DT. Noninvasive saliva-based EGFR gene mutation detection in patients with lung cancer. Am J Respir Crit Care Med. 2014 Nov 15;190(10):1117-26. PubMed Central PMCID: PMC5447327.
    c. Li Y, Elashoff D, Oh M, Sinha U, St John MA, Zhou X, Abemayor E, Wong DT. Serum circulating human mRNA profiling and its utility for oral cancer detection. J Clin Oncol. 2006 Apr 10;24(11):1754-60. PubMed PMID: 16505414.
    d. Li Y, St John MA, Zhou X, Kim Y, Sinha U, Jordan RC, Eisele D, Abemayor E, Elashoff D, Park NH, Wong DT. Salivary transcriptome diagnostics for oral cancer detection. Clin Cancer Res. 2004 Dec 15;10(24):8442-50. PubMed PMID: 15623624.
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    Collapse Research 
    Collapse research activities and funding
    UCLA Dentist-Scientist and Oral Health-Researcher Training Program
    NIH R90DE031531Jul 1, 2021 - Jun 30, 2026
    Role: Co-Principal Investigator
    UCLA Dentist-Scientist and Oral Health-Researcher Training Program
    NIH T90DE030860Jul 1, 2021 - Jun 30, 2026
    Role: Co-Principal Investigator
    Bruins in Genomics: Dental, Oral & Craniofacial Research Training Program (BIG DOC)
    NIH R25DE030117Jan 15, 2021 - Dec 31, 2025
    Role: Principal Investigator
    AFS/SERS Saliva-based SARS-CoV-2 Earliest Infection and Antibodies Detection
    NIH U18TR003778Dec 21, 2020 - Nov 30, 2022
    Role: Principal Investigator
    Acoustofluidic Separation (AFS), Purification and Raman Spectral Fingerprinting of Single EVs: From Cell of Origin to Target Cell and Biofluids
    NIH UH3TR002978Sep 5, 2019 - Jul 31, 2023
    Role: Principal Investigator
    Acoustofluidic Separation (AFS), Purification and Raman Spectral Fingerprinting of Single EVs: From Cell of Origin to Target Cell and Biofluids
    NIH UG3TR002978Sep 5, 2019 - Jul 31, 2021
    Role: Principal Investigator
    Ultra-short circulating tumor DNA (uctDNA) for liquid biopsy of non-small cell lung cancer
    NIH R21CA239052Apr 16, 2019 - Mar 31, 2021
    Role: Principal Investigator
    EFIRM-Liquid Biopsy (eLB): Ultrasensitive ctDNA and miRNA Detection for Early Assessment of Lung Cancer
    NIH U01CA233370Sep 13, 2018 - Jul 31, 2023
    Role: Principal Investigator
    Advancing EFIRM-Liquid Biopsy (eLB) to a CLIA-Certified Laboratory Developed Test (eLB-LDT) for Detection of Actionable EGFR Mutations in NSCLC Patients
    NIH UH3CA206126Mar 6, 2017 - Feb 28, 2022
    Role: Principal Investigator
    Advancing EFIRM-Liquid Biopsy (eLB) to a CLIA-Certified Laboratory Developed Test (eLB-LDT) for Detection of Actionable EGFR Mutations in NSCLC Patients
    NIH UH2CA206126Mar 6, 2017 - Feb 28, 2019
    Role: Principal Investigator
    Clinical Utility of Salivary ExRNA Biomarkers for Gastric Cancer Detection
    NIH UH3TR000923Aug 1, 2013 - Jul 31, 2020
    Role: Principal Investigator
    Clinical Utility of Salivary ExRNA Biomarkers for Gastric Cancer Detection
    NIH UH2TR000923Aug 1, 2013 - Jul 31, 2015
    Role: Principal Investigator
    Molecular Characterization of Parotid Gland Tumors
    NIH R56DE023241Sep 7, 2012 - Aug 31, 2014
    Role: Principal Investigator
    UCLA Dentist-Scientist and Oral Health-Researcher Training Program
    NIH T90DE022734Jul 1, 2012 - Jun 30, 2019
    Role: Principal Investigator
    UCLA Dentist-Scientist and Oral Health-Researcher Training Program
    NIH R90DE023057Jul 1, 2012 - Jun 30, 2018
    Role: Principal Investigator
    Systems Approach to Sjogren's Syndrome Pathogenesis (SASSP)
    NIH R01DE019255May 1, 2009 - Apr 30, 2012
    Role: Principal Investigator
    Molecular Determinants of Oral Tongue Cancer Metastasis
    NIH R01CA139596Sep 8, 2008 - Jul 31, 2014
    Role: Principal Investigator
    Salivary Biomarkers for Early Oral Cancer Detection
    NIH R01DE017170Apr 1, 2008 - Mar 31, 2013
    Role: Principal Investigator
    Collection, Stabilization and Storage of Saliva Samples for Cancer Research
    NIH R21CA126733Apr 1, 2008 - Mar 31, 2011
    Role: Principal Investigator
    Oral Fluid NanoSensor Test (OFNASET)
    NIH U01DE017790Sep 1, 2006 - Feb 28, 2012
    Role: Principal Investigator
    Salivary Biomarkers for Sjogren's Syndrome Detection-Definitive Validation
    NIH U01DE017593Aug 1, 2006 - Feb 28, 2018
    Role: Principal Investigator
    Salivary Proteomic &Genomic Biomarkers for Primary Sjogren's Syndrome
    NIH R01DE017593Aug 1, 2006 - Sep 14, 2011
    Role: Principal Investigator
    Human Salivary Proteome
    NIH U01DE016275Sep 24, 2004 - May 31, 2010
    Role: Principal Investigator
    Genomics and Proteomics of Oral Precancer Progression
    NIH R01DE015970May 1, 2004 - Mar 31, 2011
    Role: Principal Investigator
    Research Infrastructure Improvement for The UCLA SOD
    NIH R24DE015483Aug 1, 2003 - Jan 31, 2005
    Role: Principal Investigator
    p12CDK2-AP1 in Cell Cycle Control &Oral Carcinogenesis
    NIH R01DE014857Jul 1, 2003 - Apr 30, 2008
    Role: Principal Investigator
    UCLA Collaborative Oral Fluid Diagnostic Research Center
    NIH U01DE015018Sep 30, 2002 - Aug 31, 2006
    Role: Principal Investigator
    Molecular Predictors of Oral Premalignancy Progression
    NIH R21CA097771Feb 11, 2002 - Jan 31, 2004
    Role: Principal Investigator
    CELL CYCLE REGULATORS OF ORAL CANCER
    NIH P01DE012467Apr 1, 1998 - Mar 31, 2005
    Role: Co-Principal Investigator
    UCLA Dentist-Scientist &Oral Health-Scientist Training Program
    NIH T32DE007296Sep 1, 1996 - May 31, 2013
    Role: Principal Investigator
    SCIENTIFIC REVIEW &EVALUATION AWARD--NIDCR SPECIAL GRANT
    NIH U09DE011773Jul 15, 1995 - Jun 30, 2006
    Role: Principal Investigator
    SMALL INSTRUMENTATION GRANT
    NIH S15CA062317Sep 1, 1993 - Aug 31, 1994
    Role: Principal Investigator
    EOSINOPHIL AND EOSINOPHIL-DERIVED TGFS IN WOUND HEALING
    NIH R01DE010335Apr 1, 1993 - Mar 31, 1998
    Role: Principal Investigator
    RADIATION RESPONSIVENESS AND H3 MRNA IN HUMAN CANCER
    NIH R03CA056325Feb 5, 1992 - Jan 31, 1994
    Role: Principal Investigator
    SMALL INSTRUMENTATION GRANT
    NIH S15EY009450Aug 1, 1991 - Jul 31, 1992
    Role: Principal Investigator
    MOLECULAR DETERMINANTS OF ORAL CARCINOGENESIS
    NIH K04DE000318Apr 1, 1991 - Mar 31, 1996
    Role: Principal Investigator
    INSTITUTIONAL DENTIST SCIENTIST AWARD PROGRAM
    NIH K16DE000275Jul 1, 1990 - Jun 30, 2005
    Role: Co-Principal Investigator
    SMALL INSTRUMENTATION PROGRAM
    NIH S15AR040205Jun 1, 1989 - May 31, 1990
    Role: Principal Investigator
    CELLULAR/MOLECULAR DETERMINANTS IN ORAL CARCINOGENESIS
    NIH R01DE008680Aug 1, 1988 - Apr 30, 1999
    Role: Principal Investigator
    MOLECULAR DETERMINANTS OF ORAL CARCINOGENESIS
    NIH R29DE008680Aug 1, 1988 - Mar 31, 1995
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Extracellular Vesicles for Clinical Diagnostics: From Bulk Measurements to Single-Vesicle Analysis. ACS Nano. 2025 Aug 12; 19(31):28021-28109. Tran HL, Zheng W, Issadore DA, Im H, Cho YK, Zhang Y, Liu D, Liu Y, Li B, Liu F, Wong DTW, Sun J, Qian K, He M, Wan M, Zeng Y, Cheng K, Huang TJ, Chiu DT, Lee LP, Zheng L, Godwin AK, Kalluri R, Soper SA, Hu TY. PMID: 40720603; PMCID: PMC12356129.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    2. Rapid and comprehensive detection of viral antibodies and nucleic acids via an acoustofluidic integrated molecular diagnostics chip: AIMDx. Sci Adv. 2025 Jan 17; 11(3):eadt5464. Qian J, Xia J, Chiang S, Liu JF, Li K, Li F, Wei F, Aziz M, Kim Y, Go V, Morizio J, Zhong R, He Y, Yang K, Yang OO, Wong DTW, Lee LP, Huang TJ. PMID: 39813350; PMCID: PMC11734728.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    3. Direct detection of 4-dimensions of SARS-CoV-2: infection (vRNA), infectivity (antigen), binding antibody, and functional neutralizing antibody in saliva. Sci Rep. 2024 12 28; 14(1):30792. Mohammadi A, Chiang S, Li F, Wei F, Lau CS, Aziz M, Ibarrondo FJ, Fulcher JA, Yang OO, Chia D, Kim Y, Wong DTW. PMID: 39730575; PMCID: PMC11681011.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Impact of catastrophic brain injury guidelines on organ donation rates: Results of an EAST multicenter trial. J Trauma Acute Care Surg. 2025 Jan 01; 98(1):117-126. Nordham KD, Tatum D, Attia AS, Patel MB, Paramesh A, Duchesne JC, Nahmias J, Maiga AW, Peetz AB, Udekwu PO, Stiles A, Shell C, Stodghill JD, Maghsoudi T, Iacullo E, McLafferty B, Coonan E, Boudreau RM, Zimmerman SA, Shammassian B, Egodage T, Aramento I, Morris P, Metheny J, Farrell MS, Painter MD, McCabe OT, Spadafore P, Wong DT, Serrano J, Sciarretta JD, Kim P, Hayton R, Gonzales D, Murry J, Meadows K, Jacobson LE, Williams JM, Bernard AC, Smith B, Morrissey SL, Patel N, Tabello D, Teicher E, Chowdhury SM, Ahmad F, Marcos BS, West MA, Jacome TH, Davis G, Marks JA, Rattigan D, Haan JM, Lightwine K, Matsushima K, Park S, Santos A, Shrestha K, Sawyer R, VandenBerg S, Jean RJ, Hicks RC, Lueckel S, Bugaev N, Abosena W, Alvarez C, Lieser MJ, McDonald H, Dumas RP, Fitzgerald CA, Terzian WTH, Tian Y, Mousafeiris V, Mulita F, Berne JD, Mederos DR, Smith AA, Taghavi S. PMID: 39327646.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Correction: Discovery and validation of plasma, saliva and multi-fluid plasma-saliva metabolomic scores predicting insulin resistance and diabetes progression or regression among Puerto Rican adults. Diabetologia. 2024 Sep; 67(9):2016. Haslam DE, Liang L, Guo K, Martínez-Lozano M, Pérez CM, Lee CH, Morou-Bermudez E, Clish C, Wong DTW, Manson JE, Hu FB, Stampfer MJ, Joshipura K, Bhupathiraju SN. PMID: 38940920.
      View in: PubMed   Mentions:    Fields:    
    6. Corrigendum to paper entitled "Seronegative patients with primary Sjogren's syndrome and non-pSS sicca test positive for anti-SSA/Ro52 and -Ro60 in saliva" [Published in: BBA - Mol. Basis Dis. Volume 1870, Issue 5, June 2024, 167168]. Biochim Biophys Acta Mol Basis Dis. 2024 Dec; 1870(8):167474. Kamounah S, Wei F, Park JK, Song YW, Chia D, Wong DTW, Pedersen AML. PMID: 39168793.
      View in: PubMed   Mentions:    Fields:    
    7. Effect of Brolucizumab and Aflibercept on the Maximum Thickness of Pigment Epithelial Detachments and Sub-Retinal Pigment Epithelium Fluid in HAWK and HARRIER. Ophthalmol Retina. 2025 Jan; 9(1):13-21. Khanani AM, Sadda SR, Sarraf D, Tadayoni R, Wong DT, Kempf AS, Saffar I, Gedif K, Chang A. PMID: 39033924.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. Single-stranded pre-methylated 5mC adapters uncover the methylation profile of plasma ultrashort Single-stranded cell-free DNA. Nucleic Acids Res. 2024 Jun 24; 52(11):e50. Cheng JC, Swarup N, Morselli M, Huang WL, Aziz M, Caggiano C, Kordi M, Patel AA, Chia D, Kim Y, Li F, Wei F, Zaitlen N, Krysan K, Dubinett S, Pellegrini M, Wong DTW. PMID: 38797520; PMCID: PMC11194076.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    9. Discovery and validation of plasma, saliva and multi-fluid plasma-saliva metabolomic scores predicting insulin resistance and diabetes progression or regression among Puerto Rican adults. Diabetologia. 2024 Sep; 67(9):1838-1852. Haslam DE, Liang L, Guo K, Martínez-Lozano M, Pérez CM, Lee CH, Morou-Bermudez E, Clish C, Wong DTW, Manson JE, Hu FB, Stampfer MJ, Joshipura K, Bhupathiraju SN. PMID: 38772919; PMCID: PMC12190488.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Seronegative patients with primary Sjögren's syndrome and non-pSS sicca test positive for anti-SSA/Ro52 and -Ro60 in saliva. Biochim Biophys Acta Mol Basis Dis. 2024 06; 1870(5):167168. Kamounah S, Wei F, Park JK, Song YW, Chia D, Wong DTW, Pedersen AML. PMID: 38641012.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    11. Distinctive profile of monomeric and polymeric anti-SSA/Ro52 immunoglobulin A1 isoforms in saliva of patients with primary Sjögren's syndrome and Sicca. RMD Open. 2024 04 10; 10(2). Chiang S, Grogan T, Kamounah S, Wei F, Tayob N, Kim JY, Kyun Park J, Akin D, Elashoff DA, Pedersen AML, Song YW, Wong DTW, Chia D. PMID: 38599651; PMCID: PMC11015269.
      View in: PubMed   Mentions: Translation:Humans
    12. A review on the impact of single-stranded library preparation on plasma cell-free diversity for cancer detection. Front Oncol. 2024; 14:1332004. Cheng JC, Swarup N, Wong DTW, Chia D. PMID: 38511142; PMCID: PMC10951391.
      View in: PubMed   Mentions: 2  
    13. Direct Detection of 4-Dimensions of SARS-CoV-2: Infection (vRNA), Infectivity (Antigen), Binding Antibody, and Functional Neutralizing Antibody in Saliva. Res Sq. 2023 Dec 28. Mohammadi A, Chiang S, Li F, Wei F, Lau CS, Aziz M, Ibarrondo FJ, Fulcher JA, Yang OO, Chia D, Kim Y, Wong DTW. PMID: 38234820; PMCID: PMC10793499.
      View in: PubMed   Mentions: 4  
    14. Biological biomarkers of oral cancer. Periodontol 2000. 2024 Oct; 96(1):250-280. Radaic A, Kamarajan P, Cho A, Wang S, Hung GC, Najarzadegan F, Wong DT, Ton-That H, Wang CY, Kapila YL. PMID: 38073011; PMCID: PMC11163022.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    15. Correction: Multi-faceted attributes of salivary cell-free DNA as liquid biopsy biomarkers for gastric cancer detection. Biomark Res. 2023 Nov 09; 11(1):96. Swarup N, Cheng J, Choi I, Heo YJ, Kordi M, Aziz M, Arora A, Li F, Chia D, Wei F, Elashoff D, Zhang L, Kim S, Kim Y, Wong DTW. PMID: 37946258; PMCID: PMC10636843.
      View in: PubMed   Mentions:
    16. Distinct Features of Plasma Ultrashort Single-Stranded Cell-Free DNA as Biomarkers for Lung Cancer Detection. Clin Chem. 2023 11 02; 69(11):1270-1282. Cheng J, Swarup N, Li F, Kordi M, Lin CC, Yang SC, Huang WL, Aziz M, Kim Y, Chia D, Yeh YM, Wei F, Zheng D, Zhang L, Pellegrini M, Su WC, Wong DTW. PMID: 37725931; PMCID: PMC10644908.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    17. Multi-faceted attributes of salivary cell-free DNA as liquid biopsy biomarkers for gastric cancer detection. Biomark Res. 2023 Oct 10; 11(1):90. Swarup N, Cheng J, Choi I, Heo YJ, Kordi M, Aziz M, Arora A, Li F, Chia D, Wei F, Elashoff D, Zhang L, Kim S, Kim Y, Wong DTW. PMID: 37817261; PMCID: PMC10566128.
      View in: PubMed   Mentions: 10  
    18. The Liquid Biopsy Consortium: Challenges and opportunities for early cancer detection and monitoring. Cell Rep Med. 2023 10 17; 4(10):101198. Batool SM, Yekula A, Khanna P, Hsia T, Gamblin AS, Ekanayake E, Escobedo AK, You DG, Castro CM, Im H, Kilic T, Garlin MA, Skog J, Dinulescu DM, Dudley J, Agrawal N, Cheng J, Abtin F, Aberle DR, Chia D, Elashoff D, Grognan T, Krysan K, Oh SS, Strom C, Tu M, Wei F, Xian RR, Skates SJ, Zhang DY, Trinh T, Watson M, Aft R, Rawal S, Agarwal A, Kesmodel SB, Yang C, Shen C, Hochberg FH, Wong DTW, Patel AA, Papadopoulos N, Bettegowda C, Cote RJ, Srivastava S, Lee H, Carter BS, Balaj L. PMID: 37716353; PMCID: PMC10591039.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCells
    19. Multi-Faceted Attributes of Salivary Cell-free DNA as Liquid Biopsy Biomarkers for Gastric Cancer Detection. Res Sq. 2023 Jul 14. Swarup N, Cheng J, Choi I, Heo YJ, Kordi M, Li F, Aziz M, Chia D, Wei F, Elashoff D, Zhang L, Kim S, Kim Y, Wong DTW. PMID: 37503289; PMCID: PMC10371094.
      View in: PubMed   Mentions:
    20. Immunoassay Detects Salivary Anti-SSA/Ro-52 Autoantibodies in Seronegative Patients with Primary Sjögren's Syndrome. Immunohorizons. 2023 07 01; 7(7):554-561. Kamounah S, Tayob N, Chiang S, Wei F, Park JK, Kwon HM, Feng Z, Chia D, Pedersen AML, Song YW, Wong DTW. PMID: 37466644; PMCID: PMC10587502.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    21. Single-Droplet Microsensor for Ultra-Short Circulating EFGR Mutation Detection in Lung Cancer Based on Multiplex EFIRM Liquid Biopsy. Int J Mol Sci. 2023 Jun 20; 24(12). Wei F, Yu P, Cheng J, Li F, Chia D, Wong DTW. PMID: 37373532; PMCID: PMC10299723.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Evaluating Pre-Analytical Variables for Saliva Cell-Free DNA Liquid Biopsy. Diagnostics (Basel). 2023 May 09; 13(10). Salfer B, Havo D, Kuppinger S, Wong DTW, Li F, Zhang L. PMID: 37238150; PMCID: PMC10217087.
      View in: PubMed   Mentions: 5  
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    24. RNA Sequencing Analysis of Saliva exRNA. Methods Mol Biol. 2023; 2588:3-11. Kaczor-Urbanowicz KE, Wong DTW. PMID: 36418678.
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    25. A solution to the biophysical fractionation of extracellular vesicles: Acoustic Nanoscale Separation via Wave-pillar Excitation Resonance (ANSWER). Sci Adv. 2022 Nov 25; 8(47):eade0640. Zhang J, Chen C, Becker R, Rufo J, Yang S, Mai J, Zhang P, Gu Y, Wang Z, Ma Z, Xia J, Hao N, Tian Z, Wong DTW, Sadovsky Y, Lee LP, Huang TJ. PMID: 36417505; PMCID: PMC9683722.
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    29. Performance of Salivary Extracellular RNA Biomarker Panels for Gastric Cancer Differs between Distinct Populations. Cancers (Basel). 2022 Jul 26; 14(15). Kaczor-Urbanowicz KE, Saad M, Grogan TR, Li F, Heo YJ, Elashoff D, Bresalier RS, Wong DTW, Kim Y. PMID: 35892889; PMCID: PMC9331389.
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    33. Recommendations for OCT Angiography Reporting in Retinal Vascular Disease: A Delphi Approach by International Experts. Ophthalmol Retina. 2022 09; 6(9):753-761. Munk MR, Kashani AH, Tadayoni R, Korobelnik JF, Wolf S, Pichi F, Koh A, Ishibazawa A, Gaudric A, Loewenstein A, Lumbroso B, Ferrara D, Sarraf D, Wong DT, Skondra D, Rodriguez FJ, Staurenghi G, Pearce I, Kim JE, Freund KB, Parodi MB, Waheed NK, Rosen R, Spaide RF, Nakao S, Sadda S, Vujosevic S, Wong TY, Murata T, Chakravarthy U, Ogura Y, Huf W, Tian M. PMID: 35202889; PMCID: PMC9393205.
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    34. Oral Microbiome: Streptococcus mutans/Caries Concordant-Discordant Children. Front Microbiol. 2022; 13:782825. Dinis M, Agnello M, Cen L, Shokeen B, He X, Shi W, Wong DTW, Lux R, Tran NC. PMID: 35250921; PMCID: PMC8891984.
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    36. Outer Retinal Folds after Pars Plana Vitrectomy vs. Pneumatic Retinopexy for Retinal Detachment Repair: Post hoc analysis from PIVOT. Ophthalmol Retina. 2022 03; 6(3):234-242. Lee WW, Bansal A, Sadda SR, Sarraf D, Berger AR, Wong DT, Kertes PJ, Kohly RP, Hillier RJ, Muni RH. PMID: 34520841.
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    37. Associations of network-derived metabolite clusters with prevalent type 2 diabetes among adults of Puerto Rican descent. BMJ Open Diabetes Res Care. 2021 08; 9(1). Haslam DE, Liang L, Wang DD, Kelly RS, Wittenbecher C, Pérez CM, Martínez M, Lee CH, Clish CB, Wong DTW, Parnell LD, Lai CQ, Ordovás JM, Manson JE, Hu FB, Stampfer MJ, Tucker KL, Joshipura KJ, Bhupathiraju SN. PMID: 34413117; PMCID: PMC8378385.
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    38. Longitudinal Circulating Tumor DNA Analysis in Blood and Saliva for Prediction of Response to Osimertinib and Disease Progression in EGFR-Mutant Lung Adenocarcinoma. Cancers (Basel). 2021 Jul 03; 13(13). Kim C, Xi L, Cultraro CM, Wei F, Jones G, Cheng J, Shafiei A, Pham TH, Roper N, Akoth E, Ghafoor A, Misra V, Monkash N, Strom C, Tu M, Liao W, Chia D, Morris C, Steinberg SM, Bagheri H, Wong DTW, Raffeld M, Guha U. PMID: 34283064; PMCID: PMC8268167.
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    40. Postoperative Photoreceptor Integrity Following Pneumatic Retinopexy vs Pars Plana Vitrectomy for Retinal Detachment Repair: A Post Hoc Optical Coherence Tomography Analysis From the Pneumatic Retinopexy Versus Vitrectomy for the Management of Primary Rhegmatogenous Retinal Detachment Outcomes Randomized Trial. JAMA Ophthalmol. 2021 Jun 01; 139(6):620-627. Muni RH, Felfeli T, Sadda SR, Juncal VR, Francisconi CLM, Nittala MG, Lindenberg S, Gunnemann F, Berger AR, Wong DT, Altomare F, Giavedoni LR, Kohly RP, Kertes PJ, Sarraf D, Hillier RJ. PMID: 33885738; PMCID: PMC8209566.
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    41. Acoustofluidic centrifuge for nanoparticle enrichment and separation. Sci Adv. 2021 01; 7(1). Gu Y, Chen C, Mao Z, Bachman H, Becker R, Rufo J, Wang Z, Zhang P, Mai J, Yang S, Zhang J, Zhao S, Ouyang Y, Wong DTW, Sadovsky Y, Huang TJ. PMID: 33523836; PMCID: PMC7775782.
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    44. Reviews on Current Liquid Biopsy for Detection and Management of Pancreatic Cancers. Pancreas. 2020 10; 49(9):1141-1152. Kaczor-Urbanowicz KE, Cheng J, King JC, Sedarat A, Pandol SJ, Farrell JJ, Wong DTW, Kim Y. PMID: 33003085.
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    50. exRNA Atlas Analysis Reveals Distinct Extracellular RNA Cargo Types and Their Carriers Present across Human Biofluids. Cell. 2019 04 04; 177(2):463-477.e15. Murillo OD, Thistlethwaite W, Rozowsky J, Subramanian SL, Lucero R, Shah N, Jackson AR, Srinivasan S, Chung A, Laurent CD, Kitchen RR, Galeev T, Warrell J, Diao JA, Welsh JA, Hanspers K, Riutta A, Burgstaller-Muehlbacher S, Shah RV, Yeri A, Jenkins LM, Ahsen ME, Cordon-Cardo C, Dogra N, Gifford SM, Smith JT, Stolovitzky G, Tewari AK, Wunsch BH, Yadav KK, Danielson KM, Filant J, Moeller C, Nejad P, Paul A, Simonson B, Wong DK, Zhang X, Balaj L, Gandhi R, Sood AK, Alexander RP, Wang L, Wu C, Wong DTW, Galas DJ, Van Keuren-Jensen K, Patel T, Jones JC, Das S, Cheung KH, Pico AR, Su AI, Raffai RL, Laurent LC, Roth ME, Gerstein MB, Milosavljevic A. PMID: 30951672; PMCID: PMC6616370.
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    53. Electric Field-Induced Release and Measurement Liquid Biopsy for Noninvasive Early Lung Cancer Assessment. J Mol Diagn. 2018 11; 20(6):738-742. Wei F, Strom CM, Cheng J, Lin CC, Hsu CY, Soo Hoo GW, Chia D, Kim Y, Li F, Elashoff D, Grognan T, Tu M, Liao W, Xian R, Grody WW, Su WC, Wong DTW. PMID: 30309763; PMCID: PMC6198245.
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    58. Saliva-Exosomics in Cancer: Molecular Characterization of Cancer-Derived Exosomes in Saliva. Enzymes. 2017; 42:125-151. Nonaka T, Wong DTW. PMID: 29054268; PMCID: PMC6167313.
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    59. Salivary extracellular RNA biomarkers for insulin resistance detection in hispanics. Diabetes Res Clin Pract. 2017 Oct; 132:85-94. Zhang Y, Sun J, Li F, Grogan TR, Vergara JL, Luan Q, Park MS, Chia D, Elashoff D, Joshipura KJ, Wong DTW. PMID: 28802700; PMCID: PMC5741087.
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    62. Saliva exosomes from pancreatic tumor-bearing mice modulate NK cell phenotype and antitumor cytotoxicity. FASEB J. 2017 03; 31(3):998-1010. Katsiougiannis S, Chia D, Kim Y, Singh RP, Wong DT. PMID: 27895106; PMCID: PMC5295729.
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    65. Evaluation of a novel saliva-based epidermal growth factor receptor mutation detection for lung cancer: A pilot study. Thorac Cancer. 2016 Jul; 7(4):428-36. Pu D, Liang H, Wei F, Akin D, Feng Z, Yan Q, Li Y, Zhen Y, Xu L, Dong G, Wan H, Dong J, Qiu X, Qin C, Zhu D, Wang X, Sun T, Zhang W, Li C, Tang X, Qiao Y, Wong DT, Zhou Q. PMID: 27385985; PMCID: PMC4930962.
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    68. Human Salivary Micro-RNA in Patients with Parotid Salivary Gland Neoplasms. PLoS One. 2015; 10(11):e0142264. Matse JH, Yoshizawa J, Wang X, Elashoff D, Bolscher JG, Veerman EC, Leemans CR, Pegtel DM, Pegtel MD, Wong DT, Bloemena E. PMID: 26544193; PMCID: PMC4636154.
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    82. Saliva diagnostics: utilizing oral fluids to determine health status. Monogr Oral Sci. 2014; 24:88-98. Schafer CA, Schafer JJ, Yakob M, Lima P, Camargo P, Wong DT. PMID: 24862597.
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    83. Salivary biomarkers: toward future clinical and diagnostic utilities. Clin Microbiol Rev. 2013 Oct; 26(4):781-91. Yoshizawa JM, Schafer CA, Schafer JJ, Farrell JJ, Paster BJ, Wong DT. PMID: 24092855; PMCID: PMC3811231.
      View in: PubMed   Mentions: 263     Fields:    Translation:HumansCells
    84. Role of pancreatic cancer-derived exosomes in salivary biomarker development. J Biol Chem. 2013 Sep 13; 288(37):26888-97. Lau C, Kim Y, Chia D, Spielmann N, Eibl G, Elashoff D, Wei F, Lin YL, Moro A, Grogan T, Chiang S, Feinstein E, Schafer C, Farrell J, Wong DT. PMID: 23880764; PMCID: PMC3772238.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansAnimalsCells
    85. Detection of exosomal biomarker by electric field-induced release and measurement (EFIRM). Biosens Bioelectron. 2013 Jun 15; 44:115-21. Wei F, Yang J, Wong DT. PMID: 23402739; PMCID: PMC3809103.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    86. Salivary microRNAs and oral cancer detection. Methods Mol Biol. 2013; 936:313-24. Yoshizawa JM, Wong DT. PMID: 23007518; PMCID: PMC3630337.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    87. Salivary biomarker development using genomic, proteomic and metabolomic approaches. Genome Med. 2012; 4(10):82. Bonne NJ, Wong DT. PMID: 23114182; PMCID: PMC3580451.
      View in: PubMed   Mentions: 77     Fields:    
    88. A novel regulatory factor recruits the nucleosome remodeling complex to wingless integrated (Wnt) signaling gene promoters in mouse embryonic stem cells. J Biol Chem. 2012 Nov 30; 287(49):41103-17. Kim JJ, Khalid O, Vo S, Sun HH, Wong DT, Kim Y. PMID: 23074223; PMCID: PMC3510811.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    89. Salivaomics. J Am Dent Assoc. 2012 Oct; 143(10 Suppl):19S-24S. Wong DT. PMID: 23034834.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
    90. The human salivary RNA transcriptome revealed by massively parallel sequencing. Clin Chem. 2012 Sep; 58(9):1314-21. Spielmann N, Ilsley D, Gu J, Lea K, Brockman J, Heater S, Setterquist R, Wong DT. PMID: 22773539.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    91. Cdk2ap2 is a novel regulator for self-renewal of murine embryonic stem cells. Stem Cells Dev. 2012 Nov 01; 21(16):3010-8. Deshpande AM, Khalid O, Kim JJ, Kim Y, Lindgren A, Clark AT, Wong DT. PMID: 22548356; PMCID: PMC3475145.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    92. Development of transcriptomic biomarker signature in human saliva to detect lung cancer. Cell Mol Life Sci. 2012 Oct; 69(19):3341-3350. Zhang L, Xiao H, Zhou H, Santiago S, Lee JM, Garon EB, Yang J, Brinkmann O, Yan X, Akin D, Chia D, Elashoff D, Park NH, Wong DTW. PMID: 22689099; PMCID: PMC4121486.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansCells
    93. Prevalidation of salivary biomarkers for oral cancer detection. Cancer Epidemiol Biomarkers Prev. 2012 Apr; 21(4):664-72. Elashoff D, Zhou H, Reiss J, Wang J, Xiao H, Henson B, Hu S, Arellano M, Sinha U, Le A, Messadi D, Wang M, Nabili V, Lingen M, Morris D, Randolph T, Feng Z, Akin D, Kastratovic DA, Chia D, Abemayor E, Wong DT. PMID: 22301830; PMCID: PMC3319329.
      View in: PubMed   Mentions: 75     Fields:    Translation:Humans
    94. Variations of oral microbiota are associated with pancreatic diseases including pancreatic cancer. Gut. 2012 Apr; 61(4):582-8. Farrell JJ, Zhang L, Zhou H, Chia D, Elashoff D, Akin D, Paster BJ, Joshipura K, Wong DT. PMID: 21994333; PMCID: PMC3705763.
      View in: PubMed   Mentions: 356     Fields:    Translation:HumansCells
    95. Direct saliva transcriptome analysis. Clin Chem. 2011 Sep; 57(9):1295-302. Lee YH, Zhou H, Reiss JK, Yan X, Zhang L, Chia D, Wong DT. PMID: 21791578.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    96. Identification of autoantibody biomarkers for primary Sjögren's syndrome using protein microarrays. Proteomics. 2011 Apr; 11(8):1499-507. Hu S, Vissink A, Arellano M, Roozendaal C, Zhou H, Kallenberg CG, Wong DT. PMID: 21413148; PMCID: PMC3209962.
      View in: PubMed   Mentions: 56     Fields:    Translation:Humans
    97. Salivary biomarkers for periodontal disease diagnostics. Expert Opin Med Diagn. 2011 Jan; 5(1):25-35. Brinkmann O, Zhang L, Giannobile WV, Wong DT. PMID: 23484474.
      View in: PubMed   Mentions: 6     Fields:    
    98. Discovery and preclinical validation of salivary transcriptomic and proteomic biomarkers for the non-invasive detection of breast cancer. PLoS One. 2010 Dec 31; 5(12):e15573. Zhang L, Xiao H, Karlan S, Zhou H, Gross J, Elashoff D, Akin D, Yan X, Chia D, Karlan B, Wong DT. PMID: 21217834; PMCID: PMC3013113.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansCells
    99. Oral squamous cell carcinoma detection by salivary biomarkers in a Serbian population. Oral Oncol. 2011 Jan; 47(1):51-5. Brinkmann O, Kastratovic DA, Dimitrijevic MV, Konstantinovic VS, Jelovac DB, Antic J, Nesic VS, Markovic SZ, Martinovic ZR, Akin D, Spielmann N, Zhou H, Wong DT. PMID: 21109482; PMCID: PMC3032819.
      View in: PubMed   Mentions: 59     Fields:    Translation:Humans
    100. Saliva Ontology: an ontology-based framework for a Salivaomics Knowledge Base. BMC Bioinformatics. 2010 Jun 03; 11:302. Ai J, Smith B, Wong DT. PMID: 20525291; PMCID: PMC2898059.
      View in: PubMed   Mentions: 25     Fields:    
    101. Micro-heterogeneity of human saliva Peptide P-C characterized by high-resolution top-down Fourier-transform mass spectrometry. J Am Soc Mass Spectrom. 2010 May; 21(5):868-77. Halgand F, Zabrouskov V, Bassilian S, Souda P, Wong DT, Loo JA, Faull KF, Whitelegge JP. PMID: 20185333.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    102. Confident assignment of intact mass tags to human salivary cystatins using top-down Fourier-transform ion cyclotron resonance mass spectrometry. J Am Soc Mass Spectrom. 2010 Jun; 21(6):908-17. Ryan CM, Souda P, Halgand F, Wong DT, Loo JA, Faull KF, Whitelegge JP. PMID: 20189825; PMCID: PMC2873128.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    103. Salivary transcriptomic biomarkers for detection of resectable pancreatic cancer. Gastroenterology. 2010 Mar; 138(3):949-57.e1-7. Zhang L, Farrell JJ, Zhou H, Elashoff D, Akin D, Park NH, Chia D, Wong DT. PMID: 19931263; PMCID: PMC2831159.
      View in: PubMed   Mentions: 150     Fields:    Translation:Humans
    104. Bio/abiotic interface constructed from nanoscale DNA dendrimer and conducting polymer for ultrasensitive biomolecular diagnosis. Small. 2009 Aug 03; 5(15):1784-90. Wei F, Liao W, Xu Z, Yang Y, Wong DT, Ho CM. PMID: 19384878; PMCID: PMC2800851.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    105. Saliva: an emerging biofluid for early detection of diseases. Am J Dent. 2009 Aug; 22(4):241-8. Lee YH, Wong DT. PMID: 19824562; PMCID: PMC2860957.
      View in: PubMed   Mentions: 198     Fields:    Translation:Humans
    106. Cyclin-dependent kinase 2-associating protein 1 commits murine embryonic stem cell differentiation through retinoblastoma protein regulation. J Biol Chem. 2009 Aug 28; 284(35):23405-14. Kim Y, Deshpande A, Dai Y, Kim JJ, Lindgren A, Conway A, Clark AT, Wong DT. PMID: 19564334; PMCID: PMC2749114.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    107. Systemic disease-induced salivary biomarker profiles in mouse models of melanoma and non-small cell lung cancer. PLoS One. 2009 Jun 11; 4(6):e5875. Gao K, Zhou H, Zhang L, Lee JW, Zhou Q, Hu S, Wolinsky LE, Farrell J, Eibl G, Wong DT. PMID: 19517020; PMCID: PMC2691577.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    108. Targeted inactivation of p12, CDK2 associating protein 1, leads to early embryonic lethality. PLoS One. 2009; 4(2):e4518. Kim Y, McBride J, Kimlin L, Pae EK, Deshpande A, Wong DT. PMID: 19229340; PMCID: PMC2641017.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    109. Lectin microarray. Proteomics Clin Appl. 2009 Feb; 3(2):148-54. Hu S, Wong DT. PMID: 21132067; PMCID: PMC2995448.
      View in: PubMed   Mentions: 25     Fields:    
    110. Systems biology analysis of Sjögren's syndrome and mucosa-associated lymphoid tissue lymphoma in parotid glands. Arthritis Rheum. 2009 Jan; 60(1):81-92. Hu S, Zhou M, Jiang J, Wang J, Elashoff D, Gorr S, Michie SA, Spijkervet FK, Bootsma H, Kallenberg CG, Vissink A, Horvath S, Wong DT. PMID: 19116902; PMCID: PMC2718690.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    111. Cdk2ap1 is required for epigenetic silencing of Oct4 during murine embryonic stem cell differentiation. J Biol Chem. 2009 Mar 06; 284(10):6043-7. Deshpande AM, Dai YS, Kim Y, Kim J, Kimlin L, Gao K, Wong DT. PMID: 19117947; PMCID: PMC2649091.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    112. A universal pre-analytic solution for concurrent stabilization of salivary proteins, RNA and DNA at ambient temperature. Arch Oral Biol. 2009 Mar; 54(3):268-73. Jiang J, Park NJ, Hu S, Wong DT. PMID: 19047016; PMCID: PMC2674508.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    113. Salivary proteomics for oral cancer biomarker discovery. Clin Cancer Res. 2008 Oct 01; 14(19):6246-52. Hu S, Arellano M, Boontheung P, Wang J, Zhou H, Jiang J, Elashoff D, Wei R, Loo JA, Wong DT. PMID: 18829504; PMCID: PMC2877125.
      View in: PubMed   Mentions: 192     Fields:    Translation:Humans
    114. Salivary protein factors are elevated in breast cancer patients. Mol Med Rep. 2008 May-Jun; 1(3):375-8. Brooks MN, Wang J, Li Y, Zhang R, Elashoff D, Wong DT. PMID: 19844594; PMCID: PMC2763326.
      View in: PubMed   Mentions: 32     Fields:    
    115. Exon-level expression profiling: a comprehensive transcriptome analysis of oral fluids. Clin Chem. 2008 May; 54(5):824-32. Hu Z, Zimmermann BG, Zhou H, Wang J, Henson BS, Yu W, Elashoff D, Krupp G, Wong DT. PMID: 18356245; PMCID: PMC2799536.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    116. Salivary Diagnostics: Amazing as it might seem, doctors can detect and monitor diseases using molecules found in a sample of spit. Am Sci. 2008 Jan 01; 96(1):37-43. Wong DT. PMID: 19750202; PMCID: PMC2741028.
      View in: PubMed   Mentions: 15     Fields:    
    117. Salivary mRNA targets for cancer diagnostics. Oral Oncol. 2008 May; 44(5):425-9. Zimmermann BG, Wong DT. PMID: 18061522; PMCID: PMC2408659.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    118. Protein-Sequence Polymorphisms and Post-translational Modifications in Proteins from Human Saliva using Top-Down Fourier-transform Ion Cyclotron Resonance Mass Spectrometry. Int J Mass Spectrom. 2007 Dec 01; 268(2-3):190-197. Whitelegge JP, Zabrouskov V, Halgand F, Souda P, Bassilian S, Yan W, Wolinsky L, Loo JA, Wong DT, Faull KF. PMID: 19050733; PMCID: PMC2131703.
      View in: PubMed   Mentions: 24  
    119. Implications of salivary proteomics in drug discovery and development: a focus on cancer drug discovery. Drug Discov Today. 2007 Nov; 12(21-22):911-6. Hu S, Yen Y, Ann D, Wong DT. PMID: 17993408.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    120. Oral cancer proteomics. Curr Opin Mol Ther. 2007 Oct; 9(5):467-76. Hu S, Wong DT. PMID: 17932810.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    121. Genomic targets in saliva. Ann N Y Acad Sci. 2007 Mar; 1098:184-91. Zimmermann BG, Park NJ, Wong DT. PMID: 17435127; PMCID: PMC2910758.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    122. Human saliva proteome analysis. Ann N Y Acad Sci. 2007 Mar; 1098:323-9. Hu S, Loo JA, Wong DT. PMID: 17435138.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    123. Loss of p12CDK2-AP1 expression in human oral squamous cell carcinoma with disrupted transforming growth factor-beta-Smad signaling pathway. Neoplasia. 2006 Dec; 8(12):1028-36. Peng H, Shintani S, Kim Y, Wong DT. PMID: 17217620; PMCID: PMC1783720.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    124. Global expression-based classification of lymph node metastasis and extracapsular spread of oral tongue squamous cell carcinoma. Neoplasia. 2006 Nov; 8(11):925-32. Zhou X, Temam S, Oh M, Pungpravat N, Huang BL, Mao L, Wong DT. PMID: 17132224; PMCID: PMC1716013.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    125. Characterization of RNA in saliva. Clin Chem. 2006 Jun; 52(6):988-94. Park NJ, Li Y, Yu T, Brinkman BM, Wong DT. PMID: 16601067; PMCID: PMC7108156.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansCells
    126. Salivary diagnostics powered by nanotechnologies, proteomics and genomics. J Am Dent Assoc. 2006 Mar; 137(3):313-21. Wong DT. PMID: 16570464.
      View in: PubMed   Mentions: 105     Fields:    Translation:Humans
    127. Serum circulating human mRNA profiling and its utility for oral cancer detection. J Clin Oncol. 2006 Apr 10; 24(11):1754-60. Li Y, Elashoff D, Oh M, Sinha U, St John MA, Zhou X, Abemayor E, Wong DT. PMID: 16505414.
      View in: PubMed   Mentions: 56     Fields:    Translation:Humans
    128. Advancement in characterization of genomic alterations for improved diagnosis, treatment and prognostics in cancer. Expert Rev Mol Diagn. 2006 Jan; 6(1):39-50. Zhou X, Yu T, Cole SW, Wong DT. PMID: 16359266.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    129. In situ and non-invasive detection of specific bacterial species in oral biofilms using fluorescently labeled monoclonal antibodies. J Microbiol Methods. 2005 Aug; 62(2):145-60. Gu F, Lux R, Du-Thumm L, Stokes I, Kreth J, Anderson MH, Wong DT, Wolinsky L, Sullivan R, Shi W. PMID: 15935497.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    130. p12CDK2-AP1 gene therapy strategy inhibits tumor growth in an in vivo mouse model of head and neck cancer. Clin Cancer Res. 2005 May 15; 11(10):3939-48. Figueiredo ML, Kim Y, St John MA, Wong DT. PMID: 15897596.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    131. Progress in concurrent analysis of loss of heterozygosity and comparative genomic hybridization utilizing high density single nucleotide polymorphism arrays. Cancer Genet Cytogenet. 2005 May; 159(1):53-7. Zhou X, Rao NP, Cole SW, Mok SC, Chen Z, Wong DT. PMID: 15860358.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    132. Mutation of Cys105 inhibits dimerization of p12CDK2-AP1 and its growth suppressor effect. J Biol Chem. 2005 Jun 17; 280(24):23273-9. Kim Y, Ohyama H, Patel V, Figueiredo M, Wong DT. PMID: 15840587.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    133. p12(CDK2-AP1) mediates DNA damage responses induced by cisplatin. Oncogene. 2005 Jan 13; 24(3):407-18. Kim Y, McBride J, Zhang R, Zhou X, Wong DT. PMID: 15543230.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    134. Cyclin G2 dysregulation in human oral cancer. Cancer Res. 2004 Dec 15; 64(24):8980-6. Kim Y, Shintani S, Kohno Y, Zhang R, Wong DT. PMID: 15604262.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    135. Salivary transcriptome diagnostics for oral cancer detection. Clin Cancer Res. 2004 Dec 15; 10(24):8442-50. Li Y, St John MA, Zhou X, Kim Y, Sinha U, Jordan RC, Eisele D, Abemayor E, Elashoff D, Park NH, Wong DT. PMID: 15623624.
      View in: PubMed   Mentions: 222     Fields:    Translation:HumansCells
    136. Differentially expressed protein markers in human submandibular and sublingual secretions. Int J Oncol. 2004 Nov; 25(5):1423-30. Hu S, Denny P, Denny P, Xie Y, Loo JA, Wolinsky LE, Li Y, McBride J, Ogorzalek Loo RR, Navazesh M, Wong DT. PMID: 15492834.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCTClinical Trials
    137. Concurrent analysis of loss of heterozygosity (LOH) and copy number abnormality (CNA) for oral premalignancy progression using the Affymetrix 10K SNP mapping array. Hum Genet. 2004 Sep; 115(4):327-30. Zhou X, Mok SC, Chen Z, Li Y, Wong DT. PMID: 15290239.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    138. Interleukin 6 and interleukin 8 as potential biomarkers for oral cavity and oropharyngeal squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2004 Aug; 130(8):929-35. St John MA, Li Y, Zhou X, Denny P, Ho CM, Montemagno C, Shi W, Qi F, Wu B, Sinha U, Jordan R, Wolinsky L, Park NH, Liu H, Abemayor E, Wong DT. PMID: 15313862.
      View in: PubMed   Mentions: 172     Fields:    Translation:Humans
    139. Interaction of the CDK2-associated protein-1, p12(DOC-1/CDK2AP1), with its homolog, p14(DOC-1R). Biochem Biophys Res Commun. 2004 Mar 19; 315(4):998-1003. Buajeeb W, Zhang X, Ohyama H, Han D, Surarit R, Kim Y, Wong DT. PMID: 14985111.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    140. Detection of DNA copy number abnormality by microarray expression analysis. Hum Genet. 2004 Apr; 114(5):464-7. Zhou X, Cole SW, Hu S, Wong DT. PMID: 14872338.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    141. Role of p12(CDK2-AP1) in transforming growth factor-beta1-mediated growth suppression. Cancer Res. 2004 Jan 15; 64(2):490-9. Hu MG, Hu GF, Kim Y, Tsuji T, McBride J, Hinds P, Wong DT. PMID: 14744761.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    142. The nucleotide: DNA sequencing and its clinical application. J Oral Maxillofac Surg. 2002 Aug; 60(8):924-30. Kim Y, Donoff RB, Wong DT, Todd R. PMID: 12149740.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    143. The gene: the polymerase chain reaction and its clinical application. J Oral Maxillofac Surg. 2002 Jul; 60(7):808-15. Kim Y, Flynn TR, Donoff RB, Wong DT, Todd R. PMID: 12089698.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
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