David T Wong

Title(s)Professor, Dentistry Dept.
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    Other Positions
    Title(s)Professor, Head and Neck Surgery

    Collapse Research 
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    UCLA Dentist-Scientist and Oral Health-Researcher Training Program
    NIH R90DE031531Jul 1, 2021 - Jun 30, 2026
    Role: Co-Principal Investigator
    UCLA Dentist-Scientist and Oral Health-Researcher Training Program
    NIH T90DE030860Jul 1, 2021 - Jun 30, 2026
    Role: Co-Principal Investigator
    Bruins in Genomics: Dental, Oral & Craniofacial Research Training Program (BIG DOC)
    NIH R25DE030117Jan 15, 2021 - Dec 31, 2025
    Role: Principal Investigator
    AFS/SERS Saliva-based SARS-CoV-2 Earliest Infection and Antibodies Detection
    NIH U18TR003778Dec 21, 2020 - Nov 30, 2022
    Role: Principal Investigator
    Acoustofluidic Separation (AFS), Purification and Raman Spectral Fingerprinting of Single EVs: From Cell of Origin to Target Cell and Biofluids
    NIH UH3TR002978Sep 5, 2019 - Jul 31, 2023
    Role: Principal Investigator
    Acoustofluidic Separation (AFS), Purification and Raman Spectral Fingerprinting of Single EVs: From Cell of Origin to Target Cell and Biofluids
    NIH UG3TR002978Sep 5, 2019 - Jul 31, 2021
    Role: Principal Investigator
    Ultra-short circulating tumor DNA (uctDNA) for liquid biopsy of non-small cell lung cancer
    NIH R21CA239052Apr 16, 2019 - Mar 31, 2021
    Role: Principal Investigator
    EFIRM-Liquid Biopsy (eLB): Ultrasensitive ctDNA and miRNA Detection for Early Assessment of Lung Cancer
    NIH U01CA233370Sep 13, 2018 - Jul 31, 2023
    Role: Principal Investigator
    Advancing EFIRM-Liquid Biopsy (eLB) to a CLIA-Certified Laboratory Developed Test (eLB-LDT) for Detection of Actionable EGFR Mutations in NSCLC Patients
    NIH UH3CA206126Mar 6, 2017 - Feb 28, 2022
    Role: Principal Investigator
    Advancing EFIRM-Liquid Biopsy (eLB) to a CLIA-Certified Laboratory Developed Test (eLB-LDT) for Detection of Actionable EGFR Mutations in NSCLC Patients
    NIH UH2CA206126Mar 6, 2017 - Feb 28, 2019
    Role: Principal Investigator
    Clinical Utility of Salivary ExRNA Biomarkers for Gastric Cancer Detection
    NIH UH3TR000923Aug 1, 2013 - Jul 31, 2020
    Role: Principal Investigator
    Clinical Utility of Salivary ExRNA Biomarkers for Gastric Cancer Detection
    NIH UH2TR000923Aug 1, 2013 - Jul 31, 2015
    Role: Principal Investigator
    Molecular Characterization of Parotid Gland Tumors
    NIH R56DE023241Sep 7, 2012 - Aug 31, 2014
    Role: Principal Investigator
    UCLA Dentist-Scientist and Oral Health-Researcher Training Program
    NIH T90DE022734Jul 1, 2012 - Jun 30, 2019
    Role: Principal Investigator
    UCLA Dentist-Scientist and Oral Health-Researcher Training Program
    NIH R90DE023057Jul 1, 2012 - Jun 30, 2018
    Role: Principal Investigator
    Systems Approach to Sjogren's Syndrome Pathogenesis (SASSP)
    NIH R01DE019255May 1, 2009 - Apr 30, 2012
    Role: Principal Investigator
    Molecular Determinants of Oral Tongue Cancer Metastasis
    NIH R01CA139596Sep 8, 2008 - Jul 31, 2014
    Role: Principal Investigator
    Salivary Biomarkers for Early Oral Cancer Detection
    NIH R01DE017170Apr 1, 2008 - Mar 31, 2013
    Role: Principal Investigator
    Collection, Stabilization and Storage of Saliva Samples for Cancer Research
    NIH R21CA126733Apr 1, 2008 - Mar 31, 2011
    Role: Principal Investigator
    Oral Fluid NanoSensor Test (OFNASET)
    NIH U01DE017790Sep 1, 2006 - Feb 28, 2012
    Role: Principal Investigator
    Salivary Biomarkers for Sjogren's Syndrome Detection-Definitive Validation
    NIH U01DE017593Aug 1, 2006 - Feb 28, 2018
    Role: Principal Investigator
    Salivary Proteomic &Genomic Biomarkers for Primary Sjogren's Syndrome
    NIH R01DE017593Aug 1, 2006 - Sep 14, 2011
    Role: Principal Investigator
    Human Salivary Proteome
    NIH U01DE016275Sep 24, 2004 - May 31, 2010
    Role: Principal Investigator
    Genomics and Proteomics of Oral Precancer Progression
    NIH R01DE015970May 1, 2004 - Mar 31, 2011
    Role: Principal Investigator
    Research Infrastructure Improvement for The UCLA SOD
    NIH R24DE015483Aug 1, 2003 - Jan 31, 2005
    Role: Principal Investigator
    p12CDK2-AP1 in Cell Cycle Control &Oral Carcinogenesis
    NIH R01DE014857Jul 1, 2003 - Apr 30, 2008
    Role: Principal Investigator
    UCLA Collaborative Oral Fluid Diagnostic Research Center
    NIH U01DE015018Sep 30, 2002 - Aug 31, 2006
    Role: Principal Investigator
    Molecular Predictors of Oral Premalignancy Progression
    NIH R21CA097771Feb 11, 2002 - Jan 31, 2004
    Role: Principal Investigator
    NIH P01DE012467Apr 1, 1998 - Mar 31, 2005
    Role: Co-Principal Investigator
    UCLA Dentist-Scientist &Oral Health-Scientist Training Program
    NIH T32DE007296Sep 1, 1996 - May 31, 2013
    Role: Principal Investigator
    NIH U09DE011773Jul 15, 1995 - Jun 30, 2006
    Role: Principal Investigator
    NIH S15CA062317Sep 1, 1993 - Aug 31, 1994
    Role: Principal Investigator
    NIH R01DE010335Apr 1, 1993 - Mar 31, 1998
    Role: Principal Investigator
    NIH R03CA056325Feb 5, 1992 - Jan 31, 1994
    Role: Principal Investigator
    NIH S15EY009450Aug 1, 1991 - Jul 31, 1992
    Role: Principal Investigator
    NIH K04DE000318Apr 1, 1991 - Mar 31, 1996
    Role: Principal Investigator
    NIH K16DE000275Jul 1, 1990 - Jun 30, 2005
    Role: Co-Principal Investigator
    NIH S15AR040205Jun 1, 1989 - May 31, 1990
    Role: Principal Investigator
    NIH R01DE008680Aug 1, 1988 - Apr 30, 1999
    Role: Principal Investigator
    NIH R29DE008680Aug 1, 1988 - Mar 31, 1995
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Salivary Exosomes as Nanocarriers for Cancer Biomarker Delivery. Materials (Basel). 2019 Feb 21; 12(4). Cheng J, Nonaka T, Wong DTW. PMID: 30795593; PMCID: PMC6416587.
      View in: PubMed   Mentions: 22  
    2. Salivary exRNA biomarkers to detect gingivitis and monitor disease regression. J Clin Periodontol. 2018 07; 45(7):806-817. Kaczor-Urbanowicz KE, Trivedi HM, Lima PO, Camargo PM, Giannobile WV, Grogan TR, Gleber-Netto FO, Whiteman Y, Li F, Lee HJ, Dharia K, Aro K, Martin Carreras-Presas C, Amuthan S, Vartak M, Akin D, Al-Adbullah H, Bembey K, Klokkevold PR, Elashoff D, Barnes VM, Richter R, DeVizio W, Masters JG, Wong DTW. PMID: 29779262; PMCID: PMC6023773.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansPHPublic Health
    3. The Proteomics of Saliva in Sjögren's Syndrome. Rheum Dis Clin North Am. 2016 08; 42(3):449-56. Katsiougiannis S, Wong DT. PMID: 27431347; PMCID: PMC4955829.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    4. RNAPro•SAL: a device for rapid and standardized collection of saliva RNA and proteins. Biotechniques. 2015 Feb; 58(2):69-76. Chiang SH, Thomas GA, Liao W, Grogan T, Buck RL, Fuentes L, Yakob M, Laughlin MJ, Schafer C, Nazmul-Hossain A, Wei F, Elashoff D, Slowey PD, Wong DT. PMID: 25652029; PMCID: PMC4377224.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    5. Salivary biomarkers for detection of oral squamous cell carcinoma - current state and recent advances. Curr Oral Health Rep. 2014 Jun 01; 1(2):133-141. Yakob M, Fuentes L, Wang MB, Abemayor E, Wong DT. PMID: 24883261; PMCID: PMC4037864.
      View in: PubMed   Mentions: 42  
    6. Detection of exosomal biomarker by electric field-induced release and measurement (EFIRM). Biosens Bioelectron. 2013 Jun 15; 44:115-21. Wei F, Yang J, Wong DT. PMID: 23402739; PMCID: PMC3809103.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    7. Salivary microRNAs and oral cancer detection. Methods Mol Biol. 2013; 936:313-24. Yoshizawa JM, Wong DT. PMID: 23007518; PMCID: PMC3630337.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    8. Salivary biomarker development using genomic, proteomic and metabolomic approaches. Genome Med. 2012; 4(10):82. Bonne NJ, Wong DT. PMID: 23114182; PMCID: PMC3580451.
      View in: PubMed   Mentions: 56     Fields:    
    9. The human salivary RNA transcriptome revealed by massively parallel sequencing. Clin Chem. 2012 Sep; 58(9):1314-21. Spielmann N, Ilsley D, Gu J, Lea K, Brockman J, Heater S, Setterquist R, Wong DT. PMID: 22773539.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    10. Development of transcriptomic biomarker signature in human saliva to detect lung cancer. Cell Mol Life Sci. 2012 Oct; 69(19):3341-3350. Zhang L, Xiao H, Zhou H, Santiago S, Lee JM, Garon EB, Yang J, Brinkmann O, Yan X, Akin D, Chia D, Elashoff D, Park NH, Wong DTW. PMID: 22689099; PMCID: PMC4121486.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
    11. Prevalidation of salivary biomarkers for oral cancer detection. Cancer Epidemiol Biomarkers Prev. 2012 Apr; 21(4):664-72. Elashoff D, Zhou H, Reiss J, Wang J, Xiao H, Henson B, Hu S, Arellano M, Sinha U, Le A, Messadi D, Wang M, Nabili V, Lingen M, Morris D, Randolph T, Feng Z, Akin D, Kastratovic DA, Chia D, Abemayor E, Wong DT. PMID: 22301830; PMCID: PMC3319329.
      View in: PubMed   Mentions: 58     Fields:    Translation:Humans
    12. Salivary biomarkers for periodontal disease diagnostics. Expert Opin Med Diagn. 2011 Jan; 5(1):25-35. Brinkmann O, Zhang L, Giannobile WV, Wong DT. PMID: 23484474.
      View in: PubMed   Mentions: 5     Fields:    
    13. Oral squamous cell carcinoma detection by salivary biomarkers in a Serbian population. Oral Oncol. 2011 Jan; 47(1):51-5. Brinkmann O, Kastratovic DA, Dimitrijevic MV, Konstantinovic VS, Jelovac DB, Antic J, Nesic VS, Markovic SZ, Martinovic ZR, Akin D, Spielmann N, Zhou H, Wong DT. PMID: 21109482; PMCID: PMC3032819.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    14. Saliva Ontology: an ontology-based framework for a Salivaomics Knowledge Base. BMC Bioinformatics. 2010 Jun 03; 11:302. Ai J, Smith B, Wong DT. PMID: 20525291; PMCID: PMC2898059.
      View in: PubMed   Mentions: 21     Fields:    
    15. Cyclin-dependent kinase 2-associating protein 1 commits murine embryonic stem cell differentiation through retinoblastoma protein regulation. J Biol Chem. 2009 Aug 28; 284(35):23405-14. Kim Y, Deshpande A, Dai Y, Kim JJ, Lindgren A, Conway A, Clark AT, Wong DT. PMID: 19564334; PMCID: PMC2749114.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    16. Lectin microarray. Proteomics Clin Appl. 2009 Feb; 3(2):148-54. Hu S, Wong DT. PMID: 21132067; PMCID: PMC2995448.
      View in: PubMed   Mentions: 19     Fields:    
    17. Systems biology analysis of Sjögren's syndrome and mucosa-associated lymphoid tissue lymphoma in parotid glands. Arthritis Rheum. 2009 Jan; 60(1):81-92. Hu S, Zhou M, Jiang J, Wang J, Elashoff D, Gorr S, Michie SA, Spijkervet FK, Bootsma H, Kallenberg CG, Vissink A, Horvath S, Wong DT. PMID: 19116902; PMCID: PMC2718690.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    18. A universal pre-analytic solution for concurrent stabilization of salivary proteins, RNA and DNA at ambient temperature. Arch Oral Biol. 2009 Mar; 54(3):268-73. Jiang J, Park NJ, Hu S, Wong DT. PMID: 19047016; PMCID: PMC2674508.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    19. Salivary proteomics for oral cancer biomarker discovery. Clin Cancer Res. 2008 Oct 01; 14(19):6246-52. Hu S, Arellano M, Boontheung P, Wang J, Zhou H, Jiang J, Elashoff D, Wei R, Loo JA, Wong DT. PMID: 18829504; PMCID: PMC2877125.
      View in: PubMed   Mentions: 156     Fields:    Translation:Humans
    20. Exon-level expression profiling: a comprehensive transcriptome analysis of oral fluids. Clin Chem. 2008 May; 54(5):824-32. Hu Z, Zimmermann BG, Zhou H, Wang J, Henson BS, Yu W, Elashoff D, Krupp G, Wong DT. PMID: 18356245; PMCID: PMC2799536.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    21. Salivary Diagnostics: Amazing as it might seem, doctors can detect and monitor diseases using molecules found in a sample of spit. Am Sci. 2008 Jan 01; 96(1):37-43. Wong DT. PMID: 19750202; PMCID: PMC2741028.
      View in: PubMed   Mentions: 13     Fields:    
    22. Salivary mRNA targets for cancer diagnostics. Oral Oncol. 2008 May; 44(5):425-9. Zimmermann BG, Wong DT. PMID: 18061522; PMCID: PMC2408659.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    23. Implications of salivary proteomics in drug discovery and development: a focus on cancer drug discovery. Drug Discov Today. 2007 Nov; 12(21-22):911-6. Hu S, Yen Y, Ann D, Wong DT. PMID: 17993408.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    24. Oral cancer proteomics. Curr Opin Mol Ther. 2007 Oct; 9(5):467-76. Hu S, Wong DT. PMID: 17932810.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    25. Human saliva proteome analysis. Ann N Y Acad Sci. 2007 Mar; 1098:323-9. Hu S, Loo JA, Wong DT. PMID: 17435138.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    26. Global expression-based classification of lymph node metastasis and extracapsular spread of oral tongue squamous cell carcinoma. Neoplasia. 2006 Nov; 8(11):925-32. Zhou X, Temam S, Oh M, Pungpravat N, Huang BL, Mao L, Wong DT. PMID: 17132224; PMCID: PMC1716013.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    27. Characterization of RNA in saliva. Clin Chem. 2006 Jun; 52(6):988-94. Park NJ, Li Y, Yu T, Brinkman BM, Wong DT. PMID: 16601067; PMCID: PMC7108156.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
    28. In situ and non-invasive detection of specific bacterial species in oral biofilms using fluorescently labeled monoclonal antibodies. J Microbiol Methods. 2005 Aug; 62(2):145-60. Gu F, Lux R, Du-Thumm L, Stokes I, Kreth J, Anderson MH, Wong DT, Wolinsky L, Sullivan R, Shi W. PMID: 15935497.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    29. Progress in concurrent analysis of loss of heterozygosity and comparative genomic hybridization utilizing high density single nucleotide polymorphism arrays. Cancer Genet Cytogenet. 2005 May; 159(1):53-7. Zhou X, Rao NP, Cole SW, Mok SC, Chen Z, Wong DT. PMID: 15860358.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    30. Differentially expressed protein markers in human submandibular and sublingual secretions. Int J Oncol. 2004 Nov; 25(5):1423-30. Hu S, Denny P, Denny P, Xie Y, Loo JA, Wolinsky LE, Li Y, McBride J, Ogorzalek Loo RR, Navazesh M, Wong DT. PMID: 15492834.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCTClinical Trials
    31. Concurrent analysis of loss of heterozygosity (LOH) and copy number abnormality (CNA) for oral premalignancy progression using the Affymetrix 10K SNP mapping array. Hum Genet. 2004 Sep; 115(4):327-30. Zhou X, Mok SC, Chen Z, Li Y, Wong DT. PMID: 15290239.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    32. Detection of DNA copy number abnormality by microarray expression analysis. Hum Genet. 2004 Apr; 114(5):464-7. Zhou X, Cole SW, Hu S, Wong DT. PMID: 14872338.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
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