David T Wong

Title(s)Professor, Dentistry Dept.
SchoolDentistry
ORCID ORCID Icon0000-0002-0290-2206 Additional info
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    Other Positions
    Title(s)Professor, Head and Neck Surgery


    Collapse Biography 
    Collapse Education and Training
    Simon Fraser University , Burnaby, British Columbia, CanadaBSc06/1977Biochemistry
    University of British Columbia, Vancouver, British ColumbiaDMD06/1981Dental Medicine
    Harvard Medical School, Boston, Massachusetts, USADMSc06/1985Molecular Biology
    Harvard School of Dental Medicine, Boston, Massachusetts, USACertificate06/1985Oral Pathology

    Collapse Overview 
    Collapse Overview
    1. My laboratory spearheads the use of genome-wide and proteome-wide high-throughput technologies to harness the diagnostic and biological determinants pertaining to the pathogenesis of oral/head and neck cancer. In particular we are focusing on the genomic and proteomic determinants of oral cancer progression. Using a patient-based genome/proteome-wide approach; we are harnessing the genomic and proteomic determinants that distinguish progressing from non-progression oral precancers. For genomic defects, a concurrent approach to identify gene copy number abnormalities (CNA) by cDNA microarray comparative genomic hybridization (CGH) as well as SNP-based loss of heterozygosity (LOH) using the Affymetrix 100K SNP-based Mapping Arrays. For expression analysis, the Affymetrix 133+ 2 and all exon high-density oligonucleotide arrays are used. For proteomic analysis, LC-MS/MS as well as single cell proteomics are creatively being integrated. A key component to a systems approach (Weighted-Gene Co-Expression Network Analysis, WGCNA) is to seek out molecular concordance of detectable molecular defects.

    a. Das S, Ansel KM, Bitzer M, Breakefield XO, Charest A, Galas DJ, Gerstein MB, Gupta M, Milosavljevic A, McManus MT, Patel T, Raffai RL, Rozowsky J, Roth ME, Saugstad JA, Van Keuren-Jensen K, Weaver AM, Laurent LC. The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research. Cell. 2019 Apr 4;177(2):231-242. PubMed Central PMCID: PMC6601620.
    b. Yu T, Ye H, Sun W, Li KC, Chen Z, Jacobs S, Bailey DK, Wong DT, Zhou X. A forward-backward fragment assembling algorithm for the identification of genomic amplification and deletion breakpoints using high-density single nucleotide polymorphism (SNP) array. BMC Bioinformatics. 2007 May 3;8:145. PubMed Central PMCID: PMC1868765.
    c. Zhou X, Temam S, Chen Z, Ye H, Mao L, Wong DT. Allelic imbalance analysis of oral tongue squamous cell carcinoma by high-density single nucleotide polymorphism arrays using whole-genome amplified DNA. Hum Genet. 2005 Dec;118(3-4):504-7. PubMed PMID: 16193324.
    d. Zhou X, Mok SC, Chen Z, Li Y, Wong DT. Concurrent analysis of loss of heterozygosity (LOH) and copy number abnormality (CNA) for oral premalignancy progression using the Affymetrix 10K SNP mapping array. Hum Genet. 2004 Sep;115(4):327-30. PubMed PMID: 15290239.

    2. We subscribe to the belief that a central defect in human cancer lies in the dysregulation of cell cycle control. Establishing a molecular database of cell cycle regulatory genes dysregulated in head and neck cancer and understanding the molecular and biochemical pathways of these genes are areas of prime interest. Using differential expression screening assays we have identified a number of cellular genes that are differentially expressed in squamous cell carcinoma. CDK2-AP1 is a differentially expressed cellular gene that is currently being studied. CDK2-AP1 is a novel gene exhibiting growth suppressor properties. CDK2-AP1 exerts its growth suppressor function by negatively regulating the activities of DNA polymerase- /primase and cyclin-dependent kinase 2 (CDK2). CDK2-AP1 associates with DNA polymerase-/primase suppressing DNA replication, affecting predominantly the initiation step. CDK2-AP1 has been found to associates with the monomeric non-phosphorylated form of CDK2, suppressing CDK2-associated kinase activities and cell cycle progression. CDK2-AP1 also targets CDK2 for proteolysis. We are investigating the detailed biochemical and genetic mechanisms of CDK2-AP1 in cell cycle regulation, normal development and carcinogenesis. The recent excitement of this research includes finding that CDK2-AP1 -nulled mice are embryonically lethal and that CDK2-AP1 is an epigenetic regulator for differentiation competency for mouse embryonic stem cells, placing this gene at a pivotal juncture of stem cell differentiation and development.

    a. Kim JJ, Khalid O, Vo S, Sun HH, Wong DT, Kim Y. A novel regulatory factor recruits the nucleosome remodeling complex to wingless integrated (Wnt) signaling gene promoters in mouse embryonic stem cells. J Biol Chem. 2012 Nov 30;287(49):41103-17. PubMed Central PMCID: PMC3510811.
    b. Kim Y, Deshpande A, Dai Y, Kim JJ, Lindgren A, Conway A, Clark AT, Wong DT. Cyclin-dependent kinase 2-associating protein 1 commits murine embryonic stem cell differentiation through retinoblastoma protein regulation. J Biol Chem. 2009 Aug 28;284(35):23405-14. PubMed Central PMCID: PMC2749114.
    c. Deshpande AM, Dai YS, Kim Y, Kim J, Kimlin L, Gao K, Wong DT. Cdk2ap1 is required for epigenetic silencing of Oct4 during murine embryonic stem cell differentiation. J Biol Chem. 2009 Mar 6;284(10):6043-7. PubMed Central PMCID: PMC2649091.
    d. Shintani S, Ohyama H, Zhang X, McBride J, Matsuo K, Tsuji T, Hu MG, Hu G, Kohno Y, Lerman M, Todd R, Wong DT. p12(DOC-1) is a novel cyclin-dependent kinase 2-associated protein. Mol Cell Biol. 2000 Sep;20(17):6300-7. PubMed Central PMCID: PMC86104.

    3. The early detection of cancer by non-invasive means has been the holy grail for cancer researchers. My research group has been spearheading a series of concerted efforts to spearhead the scientific and translational frontiers of salivary diagnostics. The use of saliva, a non-invasive biofluid, for oral and systemic disease detection, for disease progression, and for therapeutic monitoring are highly desirable goals. We have harnessed and defined five diagnostic alphabets from human saliva: salivary proteome, transcriptome, micro-RNA, metabolome and microbiome. The availability of these diagnostic alphabets greatly enhanced the translational utilities of saliva. In parallel to the biomarker efforts, point-of-care technologies are being developed for clinical applications. The “Oral Fluid NanoSensor Test (OFNASET)” is a prototype nanotechnology-based point-of-care sensor that will have the ability to detect multiplex analytes in saliva for disease detection. Two additional highly impactful outcomes emerged from these initiatives. One is the discovery of salivary extracellular RNA in saliva, including a previously unnoticed landscape of non-coding RNA. This project by the NIH Common Fund on “Extracellular RNA Communication Consortium” opened a new horizon of saliva biology. A second facet of excitement is the finding that saliva is an optimal biofluid for liquid biopsy (saliva liquid biopsy, sLB) for detection of actionable mutations in human cancers. Using an electrochemical technology called electric field-induced release and measurement (EFIRM), circulating tumor DNA (ctDNA) was detectable in lung cancer patients with near perfect concordance with tissue based biopsy genotyping.

    a. Murillo OD, Thistlethwaite W, Rozowsky J, Subramanian SL, Lucero R, Shah N, Jackson AR, Srinivasan S, Chung A, Laurent CD, Kitchen RR, Galeev T, Warrell J, Diao JA, Welsh JA, Hanspers K, Riutta A, Burgstaller-Muehlbacher S, Shah RV, Yeri A, Jenkins LM, Ahsen ME, Cordon-Cardo C, Dogra N, Gifford SM, Smith JT, Stolovitzky G, Tewari AK, Wunsch BH, Yadav KK, Danielson KM, Filant J, Moeller C, Nejad P, Paul A, Simonson B, Wong DK, Zhang X, Balaj L, Gandhi R, Sood AK, Alexander RP, Wang L, Wu C, Wong DTW, Galas DJ, Van Keuren-Jensen K, Patel T, Jones JC, Das S, Cheung KH, Pico AR, Su AI, Raffai RL, Laurent LC, Roth ME, Gerstein MB, Milosavljevic A. exRNA Atlas Analysis Reveals Distinct Extracellular RNA Cargo Types and Their Carriers Present across Human Biofluids. Cell. 2019 Apr 4;177(2):463-477.e15. PubMed Central PMCID: PMC6616370.
    b. Wei F, Lin CC, Joon A, Feng Z, Troche G, Lira ME, Chia D, Mao M, Ho CL, Su WC, Wong DT. Noninvasive saliva-based EGFR gene mutation detection in patients with lung cancer. Am J Respir Crit Care Med. 2014 Nov 15;190(10):1117-26. PubMed Central PMCID: PMC5447327.
    c. Li Y, Elashoff D, Oh M, Sinha U, St John MA, Zhou X, Abemayor E, Wong DT. Serum circulating human mRNA profiling and its utility for oral cancer detection. J Clin Oncol. 2006 Apr 10;24(11):1754-60. PubMed PMID: 16505414.
    d. Li Y, St John MA, Zhou X, Kim Y, Sinha U, Jordan RC, Eisele D, Abemayor E, Elashoff D, Park NH, Wong DT. Salivary transcriptome diagnostics for oral cancer detection. Clin Cancer Res. 2004 Dec 15;10(24):8442-50. PubMed PMID: 15623624.
    Collapse Websites

    Collapse Research 
    Collapse Research Activities and Funding
    UCLA Dentist-Scientist and Oral Health-Researcher Training Program
    NIH R90DE031531Jul 1, 2021 - Jun 30, 2026
    Role: Co-Principal Investigator
    UCLA Dentist-Scientist and Oral Health-Researcher Training Program
    NIH T90DE030860Jul 1, 2021 - Jun 30, 2026
    Role: Co-Principal Investigator
    Bruins in Genomics: Dental, Oral & Craniofacial Research Training Program (BIG DOC)
    NIH R25DE030117Jan 15, 2021 - Dec 31, 2025
    Role: Principal Investigator
    AFS/SERS Saliva-based SARS-CoV-2 Earliest Infection and Antibodies Detection
    NIH U18TR003778Dec 21, 2020 - Nov 30, 2022
    Role: Principal Investigator
    Acoustofluidic Separation (AFS), Purification and Raman Spectral Fingerprinting of Single EVs: From Cell of Origin to Target Cell and Biofluids
    NIH UH3TR002978Sep 5, 2019 - Jul 31, 2023
    Role: Principal Investigator
    Acoustofluidic Separation (AFS), Purification and Raman Spectral Fingerprinting of Single EVs: From Cell of Origin to Target Cell and Biofluids
    NIH UG3TR002978Sep 5, 2019 - Jul 31, 2021
    Role: Principal Investigator
    Ultra-short circulating tumor DNA (uctDNA) for liquid biopsy of non-small cell lung cancer
    NIH R21CA239052Apr 16, 2019 - Mar 31, 2021
    Role: Principal Investigator
    EFIRM-Liquid Biopsy (eLB): Ultrasensitive ctDNA and miRNA Detection for Early Assessment of Lung Cancer
    NIH U01CA233370Sep 13, 2018 - Jul 31, 2023
    Role: Principal Investigator
    Advancing EFIRM-Liquid Biopsy (eLB) to a CLIA-Certified Laboratory Developed Test (eLB-LDT) for Detection of Actionable EGFR Mutations in NSCLC Patients
    NIH UH3CA206126Mar 6, 2017 - Feb 28, 2022
    Role: Principal Investigator
    Advancing EFIRM-Liquid Biopsy (eLB) to a CLIA-Certified Laboratory Developed Test (eLB-LDT) for Detection of Actionable EGFR Mutations in NSCLC Patients
    NIH UH2CA206126Mar 6, 2017 - Feb 28, 2019
    Role: Principal Investigator
    Clinical Utility of Salivary ExRNA Biomarkers for Gastric Cancer Detection
    NIH UH3TR000923Aug 1, 2013 - Jul 31, 2020
    Role: Principal Investigator
    Clinical Utility of Salivary ExRNA Biomarkers for Gastric Cancer Detection
    NIH UH2TR000923Aug 1, 2013 - Jul 31, 2015
    Role: Principal Investigator
    Molecular Characterization of Parotid Gland Tumors
    NIH R56DE023241Sep 7, 2012 - Aug 31, 2014
    Role: Principal Investigator
    UCLA Dentist-Scientist and Oral Health-Researcher Training Program
    NIH T90DE022734Jul 1, 2012 - Jun 30, 2019
    Role: Principal Investigator
    UCLA Dentist-Scientist and Oral Health-Researcher Training Program
    NIH R90DE023057Jul 1, 2012 - Jun 30, 2018
    Role: Principal Investigator
    Systems Approach to Sjogren's Syndrome Pathogenesis (SASSP)
    NIH R01DE019255May 1, 2009 - Apr 30, 2012
    Role: Principal Investigator
    Molecular Determinants of Oral Tongue Cancer Metastasis
    NIH R01CA139596Sep 8, 2008 - Jul 31, 2014
    Role: Principal Investigator
    Salivary Biomarkers for Early Oral Cancer Detection
    NIH R01DE017170Apr 1, 2008 - Mar 31, 2013
    Role: Principal Investigator
    Collection, Stabilization and Storage of Saliva Samples for Cancer Research
    NIH R21CA126733Apr 1, 2008 - Mar 31, 2011
    Role: Principal Investigator
    Oral Fluid NanoSensor Test (OFNASET)
    NIH U01DE017790Sep 1, 2006 - Feb 28, 2012
    Role: Principal Investigator
    Salivary Biomarkers for Sjogren's Syndrome Detection-Definitive Validation
    NIH U01DE017593Aug 1, 2006 - Feb 28, 2018
    Role: Principal Investigator
    Salivary Proteomic &Genomic Biomarkers for Primary Sjogren's Syndrome
    NIH R01DE017593Aug 1, 2006 - Sep 14, 2011
    Role: Principal Investigator
    Human Salivary Proteome
    NIH U01DE016275Sep 24, 2004 - May 31, 2010
    Role: Principal Investigator
    Genomics and Proteomics of Oral Precancer Progression
    NIH R01DE015970May 1, 2004 - Mar 31, 2011
    Role: Principal Investigator
    Research Infrastructure Improvement for The UCLA SOD
    NIH R24DE015483Aug 1, 2003 - Jan 31, 2005
    Role: Principal Investigator
    p12CDK2-AP1 in Cell Cycle Control &Oral Carcinogenesis
    NIH R01DE014857Jul 1, 2003 - Apr 30, 2008
    Role: Principal Investigator
    UCLA Collaborative Oral Fluid Diagnostic Research Center
    NIH U01DE015018Sep 30, 2002 - Aug 31, 2006
    Role: Principal Investigator
    Molecular Predictors of Oral Premalignancy Progression
    NIH R21CA097771Feb 11, 2002 - Jan 31, 2004
    Role: Principal Investigator
    CELL CYCLE REGULATORS OF ORAL CANCER
    NIH P01DE012467Apr 1, 1998 - Mar 31, 2005
    Role: Co-Principal Investigator
    UCLA Dentist-Scientist &Oral Health-Scientist Training Program
    NIH T32DE007296Sep 1, 1996 - May 31, 2013
    Role: Principal Investigator
    SCIENTIFIC REVIEW &EVALUATION AWARD--NIDCR SPECIAL GRANT
    NIH U09DE011773Jul 15, 1995 - Jun 30, 2006
    Role: Principal Investigator
    SMALL INSTRUMENTATION GRANT
    NIH S15CA062317Sep 1, 1993 - Aug 31, 1994
    Role: Principal Investigator
    EOSINOPHIL AND EOSINOPHIL-DERIVED TGFS IN WOUND HEALING
    NIH R01DE010335Apr 1, 1993 - Mar 31, 1998
    Role: Principal Investigator
    RADIATION RESPONSIVENESS AND H3 MRNA IN HUMAN CANCER
    NIH R03CA056325Feb 5, 1992 - Jan 31, 1994
    Role: Principal Investigator
    SMALL INSTRUMENTATION GRANT
    NIH S15EY009450Aug 1, 1991 - Jul 31, 1992
    Role: Principal Investigator
    MOLECULAR DETERMINANTS OF ORAL CARCINOGENESIS
    NIH K04DE000318Apr 1, 1991 - Mar 31, 1996
    Role: Principal Investigator
    INSTITUTIONAL DENTIST SCIENTIST AWARD PROGRAM
    NIH K16DE000275Jul 1, 1990 - Jun 30, 2005
    Role: Co-Principal Investigator
    SMALL INSTRUMENTATION PROGRAM
    NIH S15AR040205Jun 1, 1989 - May 31, 1990
    Role: Principal Investigator
    CELLULAR/MOLECULAR DETERMINANTS IN ORAL CARCINOGENESIS
    NIH R01DE008680Aug 1, 1988 - Apr 30, 1999
    Role: Principal Investigator
    MOLECULAR DETERMINANTS OF ORAL CARCINOGENESIS
    NIH R29DE008680Aug 1, 1988 - Mar 31, 1995
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Corrigendum to paper entitled "Seronegative patients with primary Sjogren's syndrome and non-pSS sicca test positive for anti-SSA/Ro52 and -Ro60 in saliva" [Published in: BBA - Mol. Basis Dis. Volume 1870, Issue 5, June 2024, 167168]. Biochim Biophys Acta Mol Basis Dis. 2024 Dec; 1870(8):167474. Kamounah S, Wei F, Park JK, Song YW, Chia D, Wong DTW, Pedersen AML. PMID: 39168793.
      View in: PubMed   Mentions:    Fields:    
    2. Seronegative patients with primary Sjögren's syndrome and non-pSS sicca test positive for anti-SSA/Ro52 and -Ro60 in saliva. Biochim Biophys Acta Mol Basis Dis. 2024 06; 1870(5):167168. Kamounah S, Wei F, Park JK, Song YW, Chia D, Wong DTW, Pedersen AML. PMID: 38641012.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Evaluating Pre-Analytical Variables for Saliva Cell-Free DNA Liquid Biopsy. Diagnostics (Basel). 2023 May 09; 13(10). Salfer B, Havo D, Kuppinger S, Wong DTW, Li F, Zhang L. PMID: 37238150; PMCID: PMC10217087.
      View in: PubMed   Mentions: 2  
    4. RNA Sequencing Analysis of Saliva exRNA. Methods Mol Biol. 2023; 2588:3-11. Kaczor-Urbanowicz KE, Wong DTW. PMID: 36418678.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Molecular consequences of fetal alcohol exposure on amniotic exosomal miRNAs with functional implications for stem cell potency and differentiation. PLoS One. 2020; 15(11):e0242276. Tavanasefat H, Li F, Koyano K, Gourtani BK, Marty V, Mulpuri Y, Lee SH, Shin KH, Wong DTW, Xiao X, Spigelman I, Kim Y. PMID: 33196678; PMCID: PMC7668603.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    6. Electric Field-Induced Release and Measurement (EFIRM): Characterization and Technical Validation of a Novel Liquid Biopsy Platform in Plasma and Saliva. J Mol Diagn. 2020 08; 22(8):1050-1062. Tu M, Cheng J, Chen YL, Jea WC, Chen WL, Chen CJ, Ho CL, Huang WL, Lin CC, Su WC, Ye Q, Deignan J, Grody W, Li F, Chia D, Wei F, Liao W, Wong DTW, Strom CM. PMID: 32497715; PMCID: PMC7416077.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    7. Clinical validity of saliva and novel technology for cancer detection. Biochim Biophys Acta Rev Cancer. 2019 08; 1872(1):49-59. Kaczor-Urbanowicz KE, Wei F, Rao SL, Kim J, Shin H, Cheng J, Tu M, Wong DTW, Kim Y. PMID: 31152821; PMCID: PMC6692231.
      View in: PubMed   Mentions: 63     Fields:    Translation:Humans
    8. Salivary Exosomes as Nanocarriers for Cancer Biomarker Delivery. Materials (Basel). 2019 Feb 21; 12(4). Cheng J, Nonaka T, Wong DTW. PMID: 30795593; PMCID: PMC6416587.
      View in: PubMed   Mentions: 34  
    9. Salivary exRNA biomarkers to detect gingivitis and monitor disease regression. J Clin Periodontol. 2018 07; 45(7):806-817. Kaczor-Urbanowicz KE, Trivedi HM, Lima PO, Camargo PM, Giannobile WV, Grogan TR, Gleber-Netto FO, Whiteman Y, Li F, Lee HJ, Dharia K, Aro K, Martin Carreras-Presas C, Amuthan S, Vartak M, Akin D, Al-Adbullah H, Bembey K, Klokkevold PR, Elashoff D, Barnes VM, Richter R, DeVizio W, Masters JG, Wong DTW. PMID: 29779262; PMCID: PMC6023773.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansPHPublic Health
    10. The Proteomics of Saliva in Sjögren's Syndrome. Rheum Dis Clin North Am. 2016 08; 42(3):449-56. Katsiougiannis S, Wong DT. PMID: 27431347; PMCID: PMC4955829.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    11. RNAPro•SAL: a device for rapid and standardized collection of saliva RNA and proteins. Biotechniques. 2015 Feb; 58(2):69-76. Chiang SH, Thomas GA, Liao W, Grogan T, Buck RL, Fuentes L, Yakob M, Laughlin MJ, Schafer C, Nazmul-Hossain A, Wei F, Elashoff D, Slowey PD, Wong DT. PMID: 25652029; PMCID: PMC4377224.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    12. Salivary biomarkers for detection of oral squamous cell carcinoma - current state and recent advances. Curr Oral Health Rep. 2014 Jun 01; 1(2):133-141. Yakob M, Fuentes L, Wang MB, Abemayor E, Wong DT. PMID: 24883261; PMCID: PMC4037864.
      View in: PubMed   Mentions: 52  
    13. Saliva diagnostics: utilizing oral fluids to determine health status. Monogr Oral Sci. 2014; 24:88-98. Schafer CA, Schafer JJ, Yakob M, Lima P, Camargo P, Wong DT. PMID: 24862597.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    14. Salivary biomarkers: toward future clinical and diagnostic utilities. Clin Microbiol Rev. 2013 Oct; 26(4):781-91. Yoshizawa JM, Schafer CA, Schafer JJ, Farrell JJ, Paster BJ, Wong DT. PMID: 24092855; PMCID: PMC3811231.
      View in: PubMed   Mentions: 229     Fields:    Translation:HumansCells
    15. Role of pancreatic cancer-derived exosomes in salivary biomarker development. J Biol Chem. 2013 Sep 13; 288(37):26888-97. Lau C, Kim Y, Chia D, Spielmann N, Eibl G, Elashoff D, Wei F, Lin YL, Moro A, Grogan T, Chiang S, Feinstein E, Schafer C, Farrell J, Wong DT. PMID: 23880764; PMCID: PMC3772238.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansAnimalsCells
    16. Detection of exosomal biomarker by electric field-induced release and measurement (EFIRM). Biosens Bioelectron. 2013 Jun 15; 44:115-21. Wei F, Yang J, Wong DT. PMID: 23402739; PMCID: PMC3809103.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    17. Salivary microRNAs and oral cancer detection. Methods Mol Biol. 2013; 936:313-24. Yoshizawa JM, Wong DT. PMID: 23007518; PMCID: PMC3630337.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    18. Salivary biomarker development using genomic, proteomic and metabolomic approaches. Genome Med. 2012; 4(10):82. Bonne NJ, Wong DT. PMID: 23114182; PMCID: PMC3580451.
      View in: PubMed   Mentions: 66     Fields:    
    19. Salivaomics. J Am Dent Assoc. 2012 Oct; 143(10 Suppl):19S-24S. Wong DT. PMID: 23034834.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    20. The human salivary RNA transcriptome revealed by massively parallel sequencing. Clin Chem. 2012 Sep; 58(9):1314-21. Spielmann N, Ilsley D, Gu J, Lea K, Brockman J, Heater S, Setterquist R, Wong DT. PMID: 22773539.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    21. Cdk2ap2 is a novel regulator for self-renewal of murine embryonic stem cells. Stem Cells Dev. 2012 Nov 01; 21(16):3010-8. Deshpande AM, Khalid O, Kim JJ, Kim Y, Lindgren A, Clark AT, Wong DT. PMID: 22548356; PMCID: PMC3475145.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    22. Development of transcriptomic biomarker signature in human saliva to detect lung cancer. Cell Mol Life Sci. 2012 Oct; 69(19):3341-3350. Zhang L, Xiao H, Zhou H, Santiago S, Lee JM, Garon EB, Yang J, Brinkmann O, Yan X, Akin D, Chia D, Elashoff D, Park NH, Wong DTW. PMID: 22689099; PMCID: PMC4121486.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCells
    23. Prevalidation of salivary biomarkers for oral cancer detection. Cancer Epidemiol Biomarkers Prev. 2012 Apr; 21(4):664-72. Elashoff D, Zhou H, Reiss J, Wang J, Xiao H, Henson B, Hu S, Arellano M, Sinha U, Le A, Messadi D, Wang M, Nabili V, Lingen M, Morris D, Randolph T, Feng Z, Akin D, Kastratovic DA, Chia D, Abemayor E, Wong DT. PMID: 22301830; PMCID: PMC3319329.
      View in: PubMed   Mentions: 72     Fields:    Translation:Humans
    24. Variations of oral microbiota are associated with pancreatic diseases including pancreatic cancer. Gut. 2012 Apr; 61(4):582-8. Farrell JJ, Zhang L, Zhou H, Chia D, Elashoff D, Akin D, Paster BJ, Joshipura K, Wong DT. PMID: 21994333; PMCID: PMC3705763.
      View in: PubMed   Mentions: 307     Fields:    Translation:HumansCells
    25. Salivary biomarkers for periodontal disease diagnostics. Expert Opin Med Diagn. 2011 Jan; 5(1):25-35. Brinkmann O, Zhang L, Giannobile WV, Wong DT. PMID: 23484474.
      View in: PubMed   Mentions: 6     Fields:    
    26. Oral squamous cell carcinoma detection by salivary biomarkers in a Serbian population. Oral Oncol. 2011 Jan; 47(1):51-5. Brinkmann O, Kastratovic DA, Dimitrijevic MV, Konstantinovic VS, Jelovac DB, Antic J, Nesic VS, Markovic SZ, Martinovic ZR, Akin D, Spielmann N, Zhou H, Wong DT. PMID: 21109482; PMCID: PMC3032819.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    27. Saliva Ontology: an ontology-based framework for a Salivaomics Knowledge Base. BMC Bioinformatics. 2010 Jun 03; 11:302. Ai J, Smith B, Wong DT. PMID: 20525291; PMCID: PMC2898059.
      View in: PubMed   Mentions: 24     Fields:    
    28. Bio/abiotic interface constructed from nanoscale DNA dendrimer and conducting polymer for ultrasensitive biomolecular diagnosis. Small. 2009 Aug 03; 5(15):1784-90. Wei F, Liao W, Xu Z, Yang Y, Wong DT, Ho CM. PMID: 19384878; PMCID: PMC2800851.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    29. Cyclin-dependent kinase 2-associating protein 1 commits murine embryonic stem cell differentiation through retinoblastoma protein regulation. J Biol Chem. 2009 Aug 28; 284(35):23405-14. Kim Y, Deshpande A, Dai Y, Kim JJ, Lindgren A, Conway A, Clark AT, Wong DT. PMID: 19564334; PMCID: PMC2749114.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    30. Lectin microarray. Proteomics Clin Appl. 2009 Feb; 3(2):148-54. Hu S, Wong DT. PMID: 21132067; PMCID: PMC2995448.
      View in: PubMed   Mentions: 21     Fields:    
    31. Systems biology analysis of Sjögren's syndrome and mucosa-associated lymphoid tissue lymphoma in parotid glands. Arthritis Rheum. 2009 Jan; 60(1):81-92. Hu S, Zhou M, Jiang J, Wang J, Elashoff D, Gorr S, Michie SA, Spijkervet FK, Bootsma H, Kallenberg CG, Vissink A, Horvath S, Wong DT. PMID: 19116902; PMCID: PMC2718690.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    32. Cdk2ap1 is required for epigenetic silencing of Oct4 during murine embryonic stem cell differentiation. J Biol Chem. 2009 Mar 06; 284(10):6043-7. Deshpande AM, Dai YS, Kim Y, Kim J, Kimlin L, Gao K, Wong DT. PMID: 19117947; PMCID: PMC2649091.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    33. A universal pre-analytic solution for concurrent stabilization of salivary proteins, RNA and DNA at ambient temperature. Arch Oral Biol. 2009 Mar; 54(3):268-73. Jiang J, Park NJ, Hu S, Wong DT. PMID: 19047016; PMCID: PMC2674508.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    34. Salivary proteomics for oral cancer biomarker discovery. Clin Cancer Res. 2008 Oct 01; 14(19):6246-52. Hu S, Arellano M, Boontheung P, Wang J, Zhou H, Jiang J, Elashoff D, Wei R, Loo JA, Wong DT. PMID: 18829504; PMCID: PMC2877125.
      View in: PubMed   Mentions: 184     Fields:    Translation:Humans
    35. Salivary protein factors are elevated in breast cancer patients. Mol Med Rep. 2008 May-Jun; 1(3):375-8. Brooks MN, Wang J, Li Y, Zhang R, Elashoff D, Wong DT. PMID: 19844594; PMCID: PMC2763326.
      View in: PubMed   Mentions: 32     Fields:    
    36. Exon-level expression profiling: a comprehensive transcriptome analysis of oral fluids. Clin Chem. 2008 May; 54(5):824-32. Hu Z, Zimmermann BG, Zhou H, Wang J, Henson BS, Yu W, Elashoff D, Krupp G, Wong DT. PMID: 18356245; PMCID: PMC2799536.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    37. Salivary Diagnostics: Amazing as it might seem, doctors can detect and monitor diseases using molecules found in a sample of spit. Am Sci. 2008 Jan 01; 96(1):37-43. Wong DT. PMID: 19750202; PMCID: PMC2741028.
      View in: PubMed   Mentions: 15     Fields:    
    38. Salivary mRNA targets for cancer diagnostics. Oral Oncol. 2008 May; 44(5):425-9. Zimmermann BG, Wong DT. PMID: 18061522; PMCID: PMC2408659.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    39. Implications of salivary proteomics in drug discovery and development: a focus on cancer drug discovery. Drug Discov Today. 2007 Nov; 12(21-22):911-6. Hu S, Yen Y, Ann D, Wong DT. PMID: 17993408.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    40. Oral cancer proteomics. Curr Opin Mol Ther. 2007 Oct; 9(5):467-76. Hu S, Wong DT. PMID: 17932810.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    41. Genomic targets in saliva. Ann N Y Acad Sci. 2007 Mar; 1098:184-91. Zimmermann BG, Park NJ, Wong DT. PMID: 17435127; PMCID: PMC2910758.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    42. Human saliva proteome analysis. Ann N Y Acad Sci. 2007 Mar; 1098:323-9. Hu S, Loo JA, Wong DT. PMID: 17435138.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    43. Global expression-based classification of lymph node metastasis and extracapsular spread of oral tongue squamous cell carcinoma. Neoplasia. 2006 Nov; 8(11):925-32. Zhou X, Temam S, Oh M, Pungpravat N, Huang BL, Mao L, Wong DT. PMID: 17132224; PMCID: PMC1716013.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    44. Characterization of RNA in saliva. Clin Chem. 2006 Jun; 52(6):988-94. Park NJ, Li Y, Yu T, Brinkman BM, Wong DT. PMID: 16601067; PMCID: PMC7108156.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
    45. In situ and non-invasive detection of specific bacterial species in oral biofilms using fluorescently labeled monoclonal antibodies. J Microbiol Methods. 2005 Aug; 62(2):145-60. Gu F, Lux R, Du-Thumm L, Stokes I, Kreth J, Anderson MH, Wong DT, Wolinsky L, Sullivan R, Shi W. PMID: 15935497.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    46. Progress in concurrent analysis of loss of heterozygosity and comparative genomic hybridization utilizing high density single nucleotide polymorphism arrays. Cancer Genet Cytogenet. 2005 May; 159(1):53-7. Zhou X, Rao NP, Cole SW, Mok SC, Chen Z, Wong DT. PMID: 15860358.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    47. Mutation of Cys105 inhibits dimerization of p12CDK2-AP1 and its growth suppressor effect. J Biol Chem. 2005 Jun 17; 280(24):23273-9. Kim Y, Ohyama H, Patel V, Figueiredo M, Wong DT. PMID: 15840587.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    48. Differentially expressed protein markers in human submandibular and sublingual secretions. Int J Oncol. 2004 Nov; 25(5):1423-30. Hu S, Denny P, Denny P, Xie Y, Loo JA, Wolinsky LE, Li Y, McBride J, Ogorzalek Loo RR, Navazesh M, Wong DT. PMID: 15492834.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCTClinical Trials
    49. Concurrent analysis of loss of heterozygosity (LOH) and copy number abnormality (CNA) for oral premalignancy progression using the Affymetrix 10K SNP mapping array. Hum Genet. 2004 Sep; 115(4):327-30. Zhou X, Mok SC, Chen Z, Li Y, Wong DT. PMID: 15290239.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    50. Interleukin 6 and interleukin 8 as potential biomarkers for oral cavity and oropharyngeal squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2004 Aug; 130(8):929-35. St John MA, Li Y, Zhou X, Denny P, Ho CM, Montemagno C, Shi W, Qi F, Wu B, Sinha U, Jordan R, Wolinsky L, Park NH, Liu H, Abemayor E, Wong DT. PMID: 15313862.
      View in: PubMed   Mentions: 156     Fields:    Translation:Humans
    51. Detection of DNA copy number abnormality by microarray expression analysis. Hum Genet. 2004 Apr; 114(5):464-7. Zhou X, Cole SW, Hu S, Wong DT. PMID: 14872338.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
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