Hung Ton-That

Title(s)Professor, Dentistry Dept.
SchoolDentistry
Emailhtonthat@dentistry.ucla.edu
ORCID ORCID Icon0000-0003-1611-0469 Additional info
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    Other Positions
    Title(s)Professor, MIMG


    Collapse Biography 
    Collapse Education and Training
    UCLA, Los AngelesB.S.1996Chemistry
    UCLA, Los AngelesPh.D.2000Microbiology
    UCLA, Los AngelesPostdoc2001Microbiology
    University of Chicago, ChicagoPostdoc2004Microbiology

    Collapse Overview 
    Collapse Overview
    The laboratory primarily focuses on three major areas of NIH-funded research (pilus assembly, protein folding, and fusobacterial pathogenesis), aiming to elucidate the molecular mechanisms of pathogenicity by Gram-negative and Gram-positive pathogens. We employ a multidisciplinary approach combining classical and modern techniques that include bacterial genetics, various biochemical methods, electron microscopy, electron cryo-tomography, X-ray crystallography, biophysics, mass spectrometry, cell-based assays, and rodent models of infection, hence providing a rich training environment to the lab trainees.

    Collapse Research 
    Collapse Research Activities and Funding
    Molecular Assembly on the Cell Surface of Actinomyces
    NIH R01DE017382-16Sep 12, 2024 - Aug 31, 2029
    Role: Principal Investigator
    Assembly and function of outer membrane tubules in Fusobacterium nucleatum
    NIH R01DE033900May 1, 2024 - Mar 31, 2029
    Role: Principal Investigator
    Metabolic modulation of Fusobacterium nucleatum virulence
    NIH R21DE032906Mar 1, 2023 - Feb 28, 2025
    Role: Principal Investigator
    UCLA Dentist-Scientist and Oral Health-Researcher Training Program
    NIH R90DE031531Jul 1, 2021 - Jun 30, 2026
    Role: Principal Investigator
    UCLA Dentist-Scientist and Oral Health-Researcher Training Program
    NIH T90DE030860Jul 1, 2021 - Jun 30, 2026
    Role: Principal Investigator
    Molecular basis of heme scavenging by Gram-positive bacteria
    NIH R01AI161828Jan 19, 2021 - Dec 31, 2026
    Role: Co-Investigator
    Virulence determinants of Fusobacterium nucleatum
    NIH R01DE026758Sep 13, 2017 - Aug 31, 2022
    Role: Principal Investigator
    Post-translocational protein folding in Gram-positive bacteria
    NIH R01DE025015Mar 1, 2015 - Aug 31, 2025
    Role: Principal Investigator
    Pilus assembly in Gram-positive bacteria
    NIH R56AI061381Aug 1, 2012 - Jul 31, 2014
    Role: Principal Investigator
    Molecular Assembly on the Cell Surface of Actinomyces
    NIH R01DE017382Feb 19, 2008 - Aug 31, 2023
    Role: Principal Investigator
    Pilus Assembly in Gram-Positive Bacteria
    NIH R01AI061381Dec 15, 2005 - Nov 30, 2011
    Role: Principal Investigator
    Cell surface polymer display in Gram-positive bacteria
    NIH R01AI052217Jun 1, 2002 - Apr 30, 2022
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Biogenesis and Functionality of Sortase-Assembled Pili in Gram-Positive Bacteria. Annu Rev Microbiol. 2024 Aug 14. Chang C, Ramirez NA, Bhat AH, Nguyen MT, Kumari P, Ton-That H, Das A, Ton-That H. PMID: 39141696.
      View in: PubMed   Mentions:    Fields:    
    2. Molecular basis for sortase-catalyzed pilus tip assembly. mBio. 2024 Sep 11; 15(9):e0148424. Bhat AH, Chang C, Das A, Ton-That H. PMID: 39092925; PMCID: PMC11389406.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    3. hTERT Peptide Fragment GV1001 Prevents the Development of Porphyromonas gingivalis-Induced Periodontal Disease and Systemic Disorders in ApoE-Deficient Mice. Int J Mol Sci. 2024 Jun 01; 25(11). Chen W, Kim SY, Lee A, Kim YJ, Chang C, Ton-That H, Kim R, Kim S, Park NH. PMID: 38892314; PMCID: PMC11172542.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Molecular basis for dual functions in pilus assembly modulated by the lid of a pilus-specific sortase. J Biol Chem. 2024 Jun; 300(6):107329. Chang C, Ton-That H, Osipiuk J, Joachimiak A, Das A, Ton-That H. PMID: 38679328; PMCID: PMC11131087.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    5. Visualization of a Cell Wall Hydrolase Inhibitor in Fusobacterium nucleatum by Immunofluorescence Microscopy. Methods Mol Biol. 2024; 2727:27-33. To K, Britton T, Ton-That H. PMID: 37815706.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    6. Single-Copy Gene Editing of a Cell Wall-Anchored Pilin in Actinomyces oris. Methods Mol Biol. 2024; 2727:125-134. Bhat AH, Das A, Ton-That H. PMID: 37815713.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    7. Detection of Cell Wall-Anchoring Machinery by Immunogold-Labeling Thin-Section Electron Microscopy. Methods Mol Biol. 2024; 2727:145-152. Chang C, Ton-That H. PMID: 37815715.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    8. Biological biomarkers of oral cancer. Periodontol 2000. 2023 Dec 10. Radaic A, Kamarajan P, Cho A, Wang S, Hung GC, Najarzadegan F, Wong DT, Ton-That H, Wang CY, Kapila YL. PMID: 38073011; PMCID: PMC11163022.
      View in: PubMed   Mentions: 8     Fields:    
    9. The respiratory enzyme complex Rnf is vital for metabolic adaptation and virulence in Fusobacterium nucleatum. mBio. 2024 Jan 16; 15(1):e0175123. Britton TA, Wu C, Chen Y-W, Franklin D, Chen Y, Camacho MI, Luong TT, Das A, Ton-That H. PMID: 38059640; PMCID: PMC10790702.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    10. The basal and major pilins in the Corynebacterium diphtheriae SpaA pilus adopt similar structures that competitively react with the pilin polymerase. Biopolymers. 2024 Jan; 115(1):e23539. Sue CK, Cheung NA, Mahoney BJ, McConnell SA, Scully JM, Fu JY, Chang C, Ton-That H, Loo JA, Clubb RT. PMID: 37227047; PMCID: PMC11164409.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    11. A cryptic oxidoreductase safeguards oxidative protein folding in Corynebacterium diphtheriae. Proc Natl Acad Sci U S A. 2023 02 21; 120(8):e2208675120. Reardon-Robinson ME, Nguyen MT, Sanchez BC, Osipiuk J, Rückert C, Chang C, Chen B, Nagvekar R, Joachimiak A, Tauch A, Das A, Ton-That H. PMID: 36787356; PMCID: PMC9974433.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    12. Genetic Determinants of Hydrogen Sulfide Biosynthesis in Fusobacterium nucleatum Are Required for Bacterial Fitness, Antibiotic Sensitivity, and Virulence. mBio. 2022 10 26; 13(5):e0193622. Chen YW, Camacho MI, Chen Y, Bhat AH, Chang C, Peluso EA, Wu C, Das A, Ton-That H. PMID: 36073813; PMCID: PMC9600241.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    13. A conserved signal-peptidase antagonist modulates membrane homeostasis of actinobacterial sortase critical for surface morphogenesis. Proc Natl Acad Sci U S A. 2022 07 12; 119(28):e2203114119. Ramirez NA, Wu C, Chang C, Siegel SD, Das A, Ton-That H. PMID: 35787040; PMCID: PMC9282373.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    14. Topical application of Porphyromonas gingivalis into the gingival pocket in mice leads to chronic‑active infection, periodontitis and systemic inflammation. Int J Mol Med. 2022 08; 50(2). Kim S, Bando Y, Chang C, Kwon J, Tarverti B, Kim D, Lee SH, Ton-That H, Kim R, Nara PL, Park NH. PMID: 35703359; PMCID: PMC9242655.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    15. The Fused Methionine Sulfoxide Reductase MsrAB Promotes Oxidative Stress Defense and Bacterial Virulence in Fusobacterium nucleatum. mBio. 2022 06 28; 13(3):e0302221. Scheible M, Nguyen CT, Luong TT, Lee JH, Chen YW, Chang C, Wittchen M, Camacho MI, Tiner BL, Wu C, Tauch A, Das A, Ton-That H. PMID: 35420473; PMCID: PMC9239216.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    16. A cell wall-anchored glycoprotein confers resistance to cation stress in Actinomyces oris biofilms. Mol Oral Microbiol. 2022 10; 37(5):206-217. Al Mamun AAM, Wu C, Chang C, Sanchez BC, Das A, Ton-That H. PMID: 35289506; PMCID: PMC9474737.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    17. Genetic and molecular determinants of polymicrobial interactions in Fusobacterium nucleatum. Proc Natl Acad Sci U S A. 2021 06 08; 118(23). Wu C, Chen YW, Scheible M, Chang C, Wittchen M, Lee JH, Luong TT, Tiner BL, Tauch A, Das A, Ton-That H. PMID: 34074747; PMCID: PMC8201914.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    18. Sortase-assembled pili in Corynebacterium diphtheriae are built using a latch mechanism. Proc Natl Acad Sci U S A. 2021 03 23; 118(12). McConnell SA, McAllister RA, Amer BR, Mahoney BJ, Sue CK, Chang C, Ton-That H, Clubb RT. PMID: 33723052; PMCID: PMC7999877.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    19. Anchoring surface proteins to the bacterial cell wall by sortase enzymes: how it started and what we know now. Curr Opin Microbiol. 2021 04; 60:73-79. Bhat AH, Nguyen MT, Das A, Ton-That H. PMID: 33611145; PMCID: PMC7990056.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    20. Ribonuclease J-Mediated mRNA Turnover Modulates Cell Shape, Metabolism and Virulence in Corynebacterium diphtheriae. Microorganisms. 2021 Feb 14; 9(2). Luong TT, Nguyen MT, Chen YW, Chang C, Lee JH, Wittchen M, Ton-That H, Cruz M, Garsin DA, Das A, Tauch A, Ton-That H. PMID: 33672886; PMCID: PMC7917786.
      View in: PubMed   Mentions: 3  
    21. Genetic Manipulation of Corynebacterium diphtheriae and Other Corynebacterium Species. Curr Protoc Microbiol. 2020 09; 58(1):e111. Chang C, Nguyen MT, Ton-That H. PMID: 32865881; PMCID: PMC8325488.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    22. Corynebacterium diphtheriae Virulence Analyses Using a Caenorhabditis elegans Model. Curr Protoc Microbiol. 2020 09; 58(1):e109. Chen YW, Ton-That H. PMID: 32658384; PMCID: PMC7939059.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    23. Novel structure of the N-terminal helical domain of BibA, a group B streptococcus immunogenic bacterial adhesin. Acta Crystallogr D Struct Biol. 2020 Aug 01; 76(Pt 8):759-770. Manne K, Chattopadhyay D, Agarwal V, Blom AM, Khare B, Chakravarthy S, Chang C, Ton-That H, Narayana SVL. PMID: 32744258; PMCID: PMC7397492.
      View in: PubMed   Mentions: 5  Translation:Cells
    24. Genetic Manipulation and Virulence Assessment of Fusobacterium nucleatum. Curr Protoc Microbiol. 2020 06; 57(1):e104. Peluso EA, Scheible M, Ton-That H, Wu C. PMID: 32539234; PMCID: PMC7398570.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    25. New Paradigms of Pilus Assembly Mechanisms in Gram-Positive Actinobacteria. Trends Microbiol. 2020 12; 28(12):999-1009. Ramirez NA, Das A, Ton-That H. PMID: 32499101; PMCID: PMC7657965.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    26. Kinetics and Optimization of the Lysine-Isopeptide Bond Forming Sortase Enzyme from Corynebacterium diphtheriae. Bioconjug Chem. 2020 06 17; 31(6):1624-1634. Sue CK, McConnell SA, Ellis-Guardiola K, Muroski JM, McAllister RA, Yu J, Alvarez AI, Chang C, Ogorzalek Loo RR, Loo JA, Ton-That H, Clubb RT. PMID: 32396336; PMCID: PMC8153732.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    27. A Cell-based Screen in Actinomyces oris to Identify Sortase Inhibitors. Sci Rep. 2020 05 22; 10(1):8520. Gosschalk JE, Chang C, Sue CK, Siegel SD, Wu C, Kattke MD, Yi SW, Damoiseaux R, Jung ME, Ton-That H, Clubb RT. PMID: 32444661; PMCID: PMC7244523.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    28. Antimicrobial sensing coupled with cell membrane remodeling mediates antibiotic resistance and virulence in Enterococcus faecalis. Proc Natl Acad Sci U S A. 2019 Dec 26; 116(52):26925-26932. Khan A, Davlieva M, Panesso D, Rincon S, Miller WR, Diaz L, Reyes J, Cruz MR, Pemberton O, Nguyen AH, Siegel SD, Planet PJ, Narechania A, Latorre M, Rios R, Singh KV, Ton-That H, Garsin DA, Tran TT, Shamoo Y, Arias CA. PMID: 31818937; PMCID: PMC6936494.
      View in: PubMed   Mentions: 30     Fields:    
    29. Cell-to-cell interaction requires optimal positioning of a pilus tip adhesin modulated by gram-positive transpeptidase enzymes. Proc Natl Acad Sci U S A. 2019 09 03; 116(36):18041-18049. Chang C, Wu C, Osipiuk J, Siegel SD, Zhu S, Liu X, Joachimiak A, Clubb RT, Das A, Ton-That H. PMID: 31427528; PMCID: PMC6731673.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    30. Erratum for Siegel et al., "Structure and Mechanism of LcpA, a Phosphotransferase That Mediates Glycosylation of a Gram-Positive Bacterial Cell Wall-Anchored Protein". mBio. 2019 04 16; 10(2). Siegel SD, Amer BR, Wu C, Sawaya MR, Gosschalk JE, Clubb RT, Ton-That H. PMID: 30992357; PMCID: PMC6469975.
      View in: PubMed   Mentions:    Fields:    
    31. Structure and Mechanism of LcpA, a Phosphotransferase That Mediates Glycosylation of a Gram-Positive Bacterial Cell Wall-Anchored Protein. mBio. 2019 02 19; 10(1). Siegel SD, Amer BR, Wu C, Sawaya MR, Gosschalk JE, Clubb RT, Ton-That H. PMID: 30782654; PMCID: PMC6381275.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    32. Protein Labeling via a Specific Lysine-Isopeptide Bond Using the Pilin Polymerizing Sortase from Corynebacterium diphtheriae. J Am Chem Soc. 2018 07 11; 140(27):8420-8423. McConnell SA, Amer BR, Muroski J, Fu J, Chang C, Ogorzalek Loo RR, Loo JA, Osipiuk J, Ton-That H, Clubb RT. PMID: 29927249; PMCID: PMC6230430.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    33. In vitro reconstitution of sortase-catalyzed pilus polymerization reveals structural elements involved in pilin cross-linking. Proc Natl Acad Sci U S A. 2018 06 12; 115(24):E5477-E5486. Chang C, Amer BR, Osipiuk J, McConnell SA, Huang IH, Hsieh V, Fu J, Nguyen HH, Muroski J, Flores E, Ogorzalek Loo RR, Loo JA, Putkey JA, Joachimiak A, Das A, Clubb RT, Ton-That H. PMID: 29844180; PMCID: PMC6004493.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    34. Forward Genetic Dissection of Biofilm Development by Fusobacterium nucleatum: Novel Functions of Cell Division Proteins FtsX and EnvC. mBio. 2018 04 24; 9(2). Wu C, Al Mamun AAM, Luong TT, Hu B, Gu J, Lee JH, D'Amore M, Das A, Ton-That H. PMID: 29691334; PMCID: PMC5915739.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    35. Structural Basis of a Thiol-Disulfide Oxidoreductase in the Hedgehog-Forming Actinobacterium Corynebacterium matruchotii. J Bacteriol. 2018 05 01; 200(9). Luong TT, Tirgar R, Reardon-Robinson ME, Joachimiak A, Osipiuk J, Ton-That H. PMID: 29440253; PMCID: PMC5892113.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    36. Transcriptome sequencing of the human pathogen Corynebacterium diphtheriae NCTC 13129 provides detailed insights into its transcriptional landscape and into DtxR-mediated transcriptional regulation. BMC Genomics. 2018 01 25; 19(1):82. Wittchen M, Busche T, Gaspar AH, Lee JH, Ton-That H, Kalinowski J, Tauch A. PMID: 29370758; PMCID: PMC5784534.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    37. Electron Transport Chain Is Biochemically Linked to Pilus Assembly Required for Polymicrobial Interactions and Biofilm Formation in the Gram-Positive Actinobacterium Actinomyces oris. mBio. 2017 06 20; 8(3). Sanchez BC, Chang C, Wu C, Tran B, Ton-That H. PMID: 28634238; PMCID: PMC5478893.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    38. Reoxidation of the Thiol-Disulfide Oxidoreductase MdbA by a Bacterial Vitamin K Epoxide Reductase in the Biofilm-Forming Actinobacterium Actinomyces oris. J Bacteriol. 2017 05 15; 199(10). Luong TT, Reardon-Robinson ME, Siegel SD, Ton-That H. PMID: 28289087; PMCID: PMC5405209.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    39. Evolution of substrate specificity in a retained enzyme driven by gene loss. Elife. 2017 03 31; 6. Juárez-Vázquez AL, Edirisinghe JN, Verduzco-Castro EA, Michalska K, Wu C, Noda-García L, Babnigg G, Endres M, Medina-Ruíz S, Santoyo-Flores J, Carrillo-Tripp M, Ton-That H, Joachimiak A, Henry CS, Barona-Gómez F. PMID: 28362260; PMCID: PMC5404923.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    40. Anchoring of LPXTG-Like Proteins to the Gram-Positive Cell Wall Envelope. Curr Top Microbiol Immunol. 2017; 404:159-175. Siegel SD, Reardon ME, Ton-That H. PMID: 27097813.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    41. Biogenesis of the Gram-positive bacterial cell envelope. Curr Opin Microbiol. 2016 12; 34:31-37. Siegel SD, Liu J, Ton-That H. PMID: 27497053; PMCID: PMC5164837.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
    42. A Type I Signal Peptidase Is Required for Pilus Assembly in the Gram-Positive, Biofilm-Forming Bacterium Actinomyces oris. J Bacteriol. 2016 08 01; 198(15):2064-73. Siegel SD, Wu C, Ton-That H. PMID: 27215787; PMCID: PMC4944219.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    43. Role of the Emp Pilus Subunits of Enterococcus faecium in Biofilm Formation, Adherence to Host Extracellular Matrix Components, and Experimental Infection. Infect Immun. 2016 05; 84(5):1491-1500. Montealegre MC, Singh KV, Somarajan SR, Yadav P, Chang C, Spencer R, Sillanpää J, Ton-That H, Murray BE. PMID: 26930703; PMCID: PMC4862714.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    44. CnaA domains in bacterial pili are efficient dissipaters of large mechanical shocks. Proc Natl Acad Sci U S A. 2016 Mar 01; 113(9):2490-5. Echelman DJ, Alegre-Cebollada J, Badilla CL, Chang C, Ton-That H, Fernández JM. PMID: 26884173; PMCID: PMC4780631.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    45. Genetics and Cell Morphology Analyses of the Actinomyces oris srtA Mutant. Methods Mol Biol. 2016; 1440:109-22. Wu C, Reardon-Robinson ME, Ton-That H. PMID: 27311668.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    46. Disulfide-Bond-Forming Pathways in Gram-Positive Bacteria. J Bacteriol. 2015 Dec 07; 198(5):746-54. Reardon-Robinson ME, Ton-That H. PMID: 26644434; PMCID: PMC4810614.
      View in: PubMed   Mentions: 35     Fields:    Translation:Cells
    47. A thiol-disulfide oxidoreductase of the Gram-positive pathogen Corynebacterium diphtheriae is essential for viability, pilus assembly, toxin production and virulence. Mol Microbiol. 2015 Dec; 98(6):1037-50. Reardon-Robinson ME, Osipiuk J, Jooya N, Chang C, Joachimiak A, Das A, Ton-That H. PMID: 26294390; PMCID: PMC4981772.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    48. A Disulfide Bond-forming Machine Is Linked to the Sortase-mediated Pilus Assembly Pathway in the Gram-positive Bacterium Actinomyces oris. J Biol Chem. 2015 Aug 28; 290(35):21393-405. Reardon-Robinson ME, Osipiuk J, Chang C, Wu C, Jooya N, Joachimiak A, Das A, Ton-That H. PMID: 26170452; PMCID: PMC4571867.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    49. The identification and functional characterization of WxL proteins from Enterococcus faecium reveal surface proteins involved in extracellular matrix interactions. J Bacteriol. 2015 Mar; 197(5):882-92. Galloway-Peña JR, Liang X, Singh KV, Yadav P, Chang C, La Rosa SL, Shelburne S, Ton-That H, Höök M, Murray BE. PMID: 25512313; PMCID: PMC4325096.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    50. Lethality of sortase depletion in Actinomyces oris caused by excessive membrane accumulation of a surface glycoprotein. Mol Microbiol. 2014 Dec; 94(6):1227-41. Wu C, Huang IH, Chang C, Reardon-Robinson ME, Das A, Ton-That H. PMID: 25230351; PMCID: PMC4262642.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    51. A slow-forming isopeptide bond in the structure of the major pilin SpaD from Corynebacterium diphtheriae has implications for pilus assembly. Acta Crystallogr D Biol Crystallogr. 2014 May; 70(Pt 5):1190-201. Kang HJ, Paterson NG, Kim CU, Middleditch M, Chang C, Ton-That H, Baker EN. PMID: 24816089; PMCID: PMC4014117.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    52. Pilus hijacking by a bacterial coaggregation factor critical for oral biofilm development. Proc Natl Acad Sci U S A. 2014 Mar 11; 111(10):3835-40. Reardon-Robinson ME, Wu C, Mishra A, Chang C, Bier N, Das A, Ton-That H. PMID: 24567409; PMCID: PMC3956193.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    53. Contribution of individual Ebp Pilus subunits of Enterococcus faecalis OG1RF to pilus biogenesis, biofilm formation and urinary tract infection. PLoS One. 2013; 8(7):e68813. Sillanpää J, Chang C, Singh KV, Montealegre MC, Nallapareddy SR, Harvey BR, Ton-That H, Murray BE. PMID: 23874774; PMCID: PMC3708956.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    54. Pilus gene pool variation and the virulence of Corynebacterium diphtheriae clinical isolates during infection of a nematode. J Bacteriol. 2013 Aug; 195(16):3774-83. Broadway MM, Rogers EA, Chang C, Huang IH, Dwivedi P, Yildirim S, Schmitt MP, Das A, Ton-That H. PMID: 23772071; PMCID: PMC3754579.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    55. Structure of Streptococcus agalactiae tip pilin GBS104: a model for GBS pili assembly and host interactions. Acta Crystallogr D Biol Crystallogr. 2013 Jun; 69(Pt 6):1073-89. Krishnan V, Dwivedi P, Kim BJ, Samal A, Macon K, Ma X, Mishra A, Doran KS, Ton-That H, Narayana SV. PMID: 23695252; PMCID: PMC3663123.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    56. Visualization of Gram-positive bacterial pili. Methods Mol Biol. 2013; 966:77-95. Chang C, Huang IH, Hendrickx AP, Ton-That H. PMID: 23299729.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    57. Pangenomic study of Corynebacterium diphtheriae that provides insights into the genomic diversity of pathogenic isolates from cases of classical diphtheria, endocarditis, and pneumonia. J Bacteriol. 2012 Jun; 194(12):3199-215. Trost E, Blom J, Soares Sde C, Huang IH, Al-Dilaimi A, Schröder J, Jaenicke S, Dorella FA, Rocha FS, Miyoshi A, Azevedo V, Schneider MP, Silva A, Camello TC, Sabbadini PS, Santos CS, Santos LS, Hirata R, Mattos-Guaraldi AL, Efstratiou A, Schmitt MP, Ton-That H, Tauch A. PMID: 22505676; PMCID: PMC3370855.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
    58. Structural determinants of Actinomyces sortase SrtC2 required for membrane localization and assembly of type 2 fimbriae for interbacterial coaggregation and oral biofilm formation. J Bacteriol. 2012 May; 194(10):2531-9. Wu C, Mishra A, Reardon ME, Huang IH, Counts SC, Das A, Ton-That H. PMID: 22447896; PMCID: PMC3347213.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    59. The crystal structure analysis of group B Streptococcus sortase C1: a model for the "lid" movement upon substrate binding. J Mol Biol. 2011 Dec 09; 414(4):563-77. Khare B, Fu ZQ, Huang IH, Ton-That H, Narayana SV. PMID: 22033482; PMCID: PMC3230703.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    60. Structural differences between the Streptococcus agalactiae housekeeping and pilus-specific sortases: SrtA and SrtC1. PLoS One. 2011; 6(8):e22995. Khare B, Krishnan V, Rajashankar KR, I-Hsiu H, Xin M, Ton-That H, Narayana SV. PMID: 21912586; PMCID: PMC3166054.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    61. Two autonomous structural modules in the fimbrial shaft adhesin FimA mediate Actinomyces interactions with streptococci and host cells during oral biofilm development. Mol Microbiol. 2011 Sep; 81(5):1205-20. Mishra A, Devarajan B, Reardon ME, Dwivedi P, Krishnan V, Cisar JO, Das A, Narayana SV, Ton-That H. PMID: 21696465; PMCID: PMC3177855.
      View in: PubMed   Mentions: 35     Fields:    Translation:Cells
    62. Dual function of a tip fimbrillin of Actinomyces in fimbrial assembly and receptor binding. J Bacteriol. 2011 Jul; 193(13):3197-206. Wu C, Mishra A, Yang J, Cisar JO, Das A, Ton-That H. PMID: 21531799; PMCID: PMC3133261.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    63. A model for group B Streptococcus pilus type 1: the structure of a 35-kDa C-terminal fragment of the major pilin GBS80. J Mol Biol. 2011 Apr 15; 407(5):731-43. Vengadesan K, Ma X, Dwivedi P, Ton-That H, Narayana SV. PMID: 21333654; PMCID: PMC3102248.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    64. Cell surface display of minor pilin adhesins in the form of a simple heterodimeric assembly in Corynebacterium diphtheriae. Mol Microbiol. 2011 Mar; 79(5):1236-47. Chang C, Mandlik A, Das A, Ton-That H. PMID: 21205008; PMCID: PMC3043122.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    65. Adhesion by pathogenic corynebacteria. Adv Exp Med Biol. 2011; 715:91-103. Rogers EA, Das A, Ton-That H. PMID: 21557059.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    66. Purification, crystallization and halide phasing of a Streptococcus agalactiae backbone pilin GBS80 fragment. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Dec 01; 66(Pt 12):1666-9. Vengadesan K, Ma X, Dwivedi P, Ton-That H, Narayana SV. PMID: 21139220; PMCID: PMC2998379.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    67. Preliminary crystallographic study of the Streptococcus agalactiae sortases, sortase A and sortase C1. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Sep 01; 66(Pt 9):1096-100. Khare B, Samal A, Vengadesan K, Rajashankar KR, Ma X, Huang IH, Ton-That H, Narayana SV. PMID: 20823536; PMCID: PMC2935237.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    68. Allelic exchange in Actinomyces oris with mCherry fluorescence counterselection. Appl Environ Microbiol. 2010 Sep; 76(17):5987-9. Wu C, Ton-That H. PMID: 20601506; PMCID: PMC2935053.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    69. Characterization of the ebp(fm) pilus-encoding operon of Enterococcus faecium and its role in biofilm formation and virulence in a murine model of urinary tract infection. Virulence. 2010 Jul-Aug; 1(4):236-46. Sillanpää J, Nallapareddy SR, Singh KV, Prakash VP, Fothergill T, Ton-That H, Murray BE. PMID: 20676385; PMCID: PMC2910428.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    70. The Actinomyces oris type 2 fimbrial shaft FimA mediates co-aggregation with oral streptococci, adherence to red blood cells and biofilm development. Mol Microbiol. 2010 Aug; 77(4):841-54. Mishra A, Wu C, Yang J, Cisar JO, Das A, Ton-That H. PMID: 20545853; PMCID: PMC2946971.
      View in: PubMed   Mentions: 50     Fields:    Translation:Cells
    71. The Corynebacterium diphtheriae shaft pilin SpaA is built of tandem Ig-like modules with stabilizing isopeptide and disulfide bonds. Proc Natl Acad Sci U S A. 2009 Oct 06; 106(40):16967-71. Kang HJ, Paterson NG, Gaspar AH, Ton-That H, Baker EN. PMID: 19805181; PMCID: PMC2761350.
      View in: PubMed   Mentions: 67     Fields:    Translation:Cells
    72. Acyl enzyme intermediates in sortase-catalyzed pilus morphogenesis in gram-positive bacteria. J Bacteriol. 2009 Sep; 191(18):5603-12. Guttilla IK, Gaspar AH, Swierczynski A, Swaminathan A, Dwivedi P, Das A, Ton-That H. PMID: 19592583; PMCID: PMC2737948.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    73. The molecular switch that activates the cell wall anchoring step of pilus assembly in gram-positive bacteria. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):14147-52. Mandlik A, Das A, Ton-That H. PMID: 18779588; PMCID: PMC2734112.
      View in: PubMed   Mentions: 68     Fields:    Translation:Cells
    74. Pili in Gram-positive bacteria: assembly, involvement in colonization and biofilm development. Trends Microbiol. 2008 Jan; 16(1):33-40. Mandlik A, Swierczynski A, Das A, Ton-That H. PMID: 18083568; PMCID: PMC2841691.
      View in: PubMed   Mentions: 184     Fields:    Translation:Cells
    75. Housekeeping sortase facilitates the cell wall anchoring of pilus polymers in Corynebacterium diphtheriae. Mol Microbiol. 2007 Nov; 66(4):961-74. Swaminathan A, Mandlik A, Swierczynski A, Gaspar A, Das A, Ton-That H. PMID: 17919283; PMCID: PMC2841690.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    76. An IgG-like domain in the minor pilin GBS52 of Streptococcus agalactiae mediates lung epithelial cell adhesion. Structure. 2007 Aug; 15(8):893-903. Krishnan V, Gaspar AH, Ye N, Mandlik A, Ton-That H, Narayana SV. PMID: 17697995; PMCID: PMC2844079.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    77. Corynebacterium diphtheriae employs specific minor pilins to target human pharyngeal epithelial cells. Mol Microbiol. 2007 Apr; 64(1):111-24. Mandlik A, Swierczynski A, Das A, Ton-That H. PMID: 17376076; PMCID: PMC2844904.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansCells
    78. Sortase-catalyzed assembly of distinct heteromeric fimbriae in Actinomyces naeslundii. J Bacteriol. 2007 Apr; 189(8):3156-65. Mishra A, Das A, Cisar JO, Ton-That H. PMID: 17277070; PMCID: PMC1855841.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    79. Type III pilus of corynebacteria: Pilus length is determined by the level of its major pilin subunit. J Bacteriol. 2006 Sep; 188(17):6318-25. Swierczynski A, Ton-That H. PMID: 16923899; PMCID: PMC1595371.
      View in: PubMed   Mentions: 55     Fields:    Translation:Cells
    80. Assembly of distinct pilus structures on the surface of Corynebacterium diphtheriae. J Bacteriol. 2006 Feb; 188(4):1526-33. Gaspar AH, Ton-That H. PMID: 16452436; PMCID: PMC1367254.
      View in: PubMed   Mentions: 70     Fields:    Translation:Cells
    81. Bacillus anthracis sortase A (SrtA) anchors LPXTG motif-containing surface proteins to the cell wall envelope. J Bacteriol. 2005 Jul; 187(13):4646-55. Gaspar AH, Marraffini LA, Glass EM, Debord KL, Ton-That H, Schneewind O. PMID: 15968076; PMCID: PMC1151759.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    82. Protein sorting to the cell wall envelope of Gram-positive bacteria. Biochim Biophys Acta. 2004 Nov 11; 1694(1-3):269-78. Ton-That H, Marraffini LA, Schneewind O. PMID: 15546671.
      View in: PubMed   Mentions: 106     Fields:    Translation:Cells
    83. The secretion signal of YopN, a regulatory protein of the Yersinia enterocolitica type III secretion pathway. J Bacteriol. 2004 Sep; 186(18):6320-4. Goss JW, Sorg JA, Ramamurthi KS, Ton-That H, Schneewind O. PMID: 15342604; PMCID: PMC515147.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    84. Anchoring of surface proteins to the cell wall of Staphylococcus aureus. A conserved arginine residue is required for efficient catalysis of sortase A. J Biol Chem. 2004 Sep 03; 279(36):37763-70. Marraffini LA, Ton-That H, Zong Y, Narayana SV, Schneewind O. PMID: 15247224.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    85. Sortases and pilin elements involved in pilus assembly of Corynebacterium diphtheriae. Mol Microbiol. 2004 Jul; 53(1):251-61. Ton-That H, Marraffini LA, Schneewind O. PMID: 15225319.
      View in: PubMed   Mentions: 92     Fields:    Translation:Cells
    86. Assembly of pili in Gram-positive bacteria. Trends Microbiol. 2004 May; 12(5):228-34. Ton-That H, Schneewind O. PMID: 15120142.
      View in: PubMed   Mentions: 108     Fields:    Translation:Cells
    87. Crystal structures of Staphylococcus aureus sortase A and its substrate complex. J Biol Chem. 2004 Jul 23; 279(30):31383-9. Zong Y, Bice TW, Ton-That H, Schneewind O, Narayana SV. PMID: 15117963.
      View in: PubMed   Mentions: 90     Fields:    Translation:Cells
    88. Assembly of pili on the surface of Corynebacterium diphtheriae. Mol Microbiol. 2003 Nov; 50(4):1429-38. Ton-That H, Schneewind O. PMID: 14622427.
      View in: PubMed   Mentions: 173     Fields:    Translation:Cells
    89. Anchoring of surface proteins to the cell wall of Staphylococcus aureus. III. Lipid II is an in vivo peptidoglycan substrate for sortase-catalyzed surface protein anchoring. J Biol Chem. 2002 May 03; 277(18):16241-8. Perry AM, Ton-That H, Mazmanian SK, Schneewind O. PMID: 11856734.
      View in: PubMed   Mentions: 96     Fields:    Translation:Cells
    90. An iron-regulated sortase anchors a class of surface protein during Staphylococcus aureus pathogenesis. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):2293-8. Mazmanian SK, Ton-That H, Su K, Schneewind O. PMID: 11830639; PMCID: PMC122358.
      View in: PubMed   Mentions: 160     Fields:    Translation:Cells
    91. Anchoring of surface proteins to the cell wall of Staphylococcus aureus. Cysteine 184 and histidine 120 of sortase form a thiolate-imidazolium ion pair for catalysis. J Biol Chem. 2002 Mar 01; 277(9):7447-52. Ton-That H, Mazmanian SK, Alksne L, Schneewind O. PMID: 11714722.
      View in: PubMed   Mentions: 49     Fields:    Translation:Cells
    92. Sortase-catalysed anchoring of surface proteins to the cell wall of Staphylococcus aureus. Mol Microbiol. 2001 Jun; 40(5):1049-57. Mazmanian SK, Ton-That H, Schneewind O. PMID: 11401711.
      View in: PubMed   Mentions: 154     Fields:    Translation:Cells
    93. Structure of sortase, the transpeptidase that anchors proteins to the cell wall of Staphylococcus aureus. Proc Natl Acad Sci U S A. 2001 May 22; 98(11):6056-61. Ilangovan U, Ton-That H, Iwahara J, Schneewind O, Clubb RT. PMID: 11371637; PMCID: PMC33421.
      View in: PubMed   Mentions: 107     Fields:    Translation:Cells
    94. Assignment of the 1H, 13C and 15N signals of Sortase. J Biomol NMR. 2001 Apr; 19(4):379-80. Ilangovan U, Iwahara J, Ton-That H, Schneewind O, Clubb RT. PMID: 11370786.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    95. Anchoring of surface proteins to the cell wall of Staphylococcus aureus. Sortase catalyzed in vitro transpeptidation reaction using LPXTG peptide and NH(2)-Gly(3) substrates. J Biol Chem. 2000 Mar 31; 275(13):9876-81. Ton-That H, Mazmanian SK, Faull KF, Schneewind O. PMID: 10734144.
      View in: PubMed   Mentions: 107     Fields:    Translation:Cells
    96. Purification and characterization of sortase, the transpeptidase that cleaves surface proteins of Staphylococcus aureus at the LPXTG motif. Proc Natl Acad Sci U S A. 1999 Oct 26; 96(22):12424-9. Ton-That H, Liu G, Mazmanian SK, Faull KF, Schneewind O. PMID: 10535938; PMCID: PMC22937.
      View in: PubMed   Mentions: 218     Fields:    Translation:Cells
    97. Anchor structure of staphylococcal surface proteins. IV. Inhibitors of the cell wall sorting reaction. J Biol Chem. 1999 Aug 20; 274(34):24316-20. Ton-That H, Schneewind O. PMID: 10446208.
      View in: PubMed   Mentions: 64     Fields:    Translation:Cells
    98. Staphylococcus aureus sortase, an enzyme that anchors surface proteins to the cell wall. Science. 1999 Jul 30; 285(5428):760-3. Mazmanian SK, Liu G, Ton-That H, Schneewind O. PMID: 10427003.
      View in: PubMed   Mentions: 403     Fields:    Translation:Cells
    99. Multiple enzymatic activities of the murein hydrolase from staphylococcal phage phi11. Identification of a D-alanyl-glycine endopeptidase activity. J Biol Chem. 1999 May 28; 274(22):15847-56. Navarre WW, Ton-That H, Faull KF, Schneewind O. PMID: 10336488.
      View in: PubMed   Mentions: 67     Fields:    Translation:Cells
    100. Anchor structure of staphylococcal surface proteins. III. Role of the FemA, FemB, and FemX factors in anchoring surface proteins to the bacterial cell wall. J Biol Chem. 1998 Oct 30; 273(44):29143-9. Ton-That H, Labischinski H, Berger-Bächi B, Schneewind O. PMID: 9786923.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    101. Anchor structure of staphylococcal surface proteins. II. Cooh-terminal structure of muramidase and amidase-solubilized surface protein. J Biol Chem. 1998 Oct 30; 273(44):29135-42. Navarre WW, Ton-That H, Faull KF, Schneewind O. PMID: 9786922.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    102. Anchor structure of staphylococcal surface proteins. A branched peptide that links the carboxyl terminus of proteins to the cell wall. J Biol Chem. 1997 Aug 29; 272(35):22285-92. Ton-That H, Faull KF, Schneewind O. PMID: 9268378.
      View in: PubMed   Mentions: 49     Fields:    Translation:Cells
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