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Mittelman, Steven David

Title(s)Professor, Pediatrics
Phone56496
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    Collapse Research 
    Collapse Research Activities and Funding
    Sequestration and deactivation of anthracycline by adipocytes in the leukemia microenvironment
    NIH/NCI R01CA213129Aug 15, 2017 - Jul 31, 2022
    Role: Principal Investigator
    Adipocytes are Important Players in the Acute Lymphoblastic Leukemia Microenvironment
    NIH/NCI R01CA201444Jul 15, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Investigating the Role of Adipocytes on Leukemia Relapse
    NIH/NCI R01CA139060Jul 10, 2009 - May 31, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Gang EJ, Kim HN, Hsieh YT, Ruan Y, Ogana H, Pham J, Lee S, Geng H, Park E, Klemm L, Willman CL, Carroll WL, Mittelman SD, Orgel E, Oberley MJ, Parekh C, Abdel-Azim H, Bhojwani D, Wayne AS, De Arcangelis A, Georges-Labouesse E, Wayner E, Bönig HB, Minasyan A, Ten Hoeve J, Graeber T, Müschen M, Heisterkamp N, Kim YM. Integrin a6 mediates drug resistance of acute lymphoblastic B-cell leukemia. Blood. 2020 Mar 27. PMID: 32219444.
      View in: PubMed
    2. Sea JL, Orgel E, Chen T, Paszkiewicz RL, Krall AS, Oberley MJ, Stiles L, Mittelman SD. Levocarnitine does not impair chemotherapy cytotoxicity against acute lymphoblastic leukemia. Leuk Lymphoma. 2020 Feb; 61(2):420-428. PMID: 31526067.
      View in: PubMed
    3. Orgel E, Sea JL, Mittelman SD. Mechanisms by Which Obesity Impacts Survival from Acute Lymphoblastic Leukemia. J Natl Cancer Inst Monogr. 2019 Sep 01; 2019(54):152-156. PMID: 31532535.
      View in: PubMed
    4. Mueske NM, Mittelman SD, Wren TAL, Gilsanz V, Orgel E. Myosteatosis in adolescents and young adults treated for acute lymphoblastic leukemia. Leuk Lymphoma. 2019 Dec; 60(13):3146-3153. PMID: 31264493.
      View in: PubMed
    5. Rosen EL, Thambundit A, Mehler PS, Mittelman SD. Central diabetes insipidus associated with refeeding in anorexia nervosa: A case report. Int J Eat Disord. 2019 06; 52(6):752-756. PMID: 31038775.
      View in: PubMed
    6. Singer K, Katz ML, Mittelman SD. Proposed endocrine funding priorities for the NICHD strategic plan: expert opinion from the Pediatric Endocrine Society. Pediatr Res. 2019 08; 86(2):141-143. PMID: 30995675.
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    7. Fallah R, Du L, Braverman LE, He X, Segura-Harrison M, Yeh MW, Pearce EN, Chiu HK, Mittelman SD, Leung AM. Iodine Nutrition in Weaning Infants in the United States. Thyroid. 2019 04; 29(4):573-576. PMID: 30827204.
      View in: PubMed
    8. Vidmar AP, Salvy SJ, Pretlow R, Mittelman SD, Wee CP, Fink C, Steven Fox D, Raymond JK. An addiction-based mobile health weight loss intervention: protocol of a randomized controlled trial. Contemp Clin Trials. 2019 03; 78:11-19. PMID: 30654026.
      View in: PubMed
    9. Oliveira FMS, Tran WH, Lesser DJ, Bhatia R, Keens TG, Mittelman SD, Davidson Ward SL, Khoo MCK. Abnormalities in autonomic function in obese boys at-risk for insulin resistance and obstructive sleep apnea. Pediatr Res. 2019 05; 85(6):790-798. PMID: 30420708.
      View in: PubMed
    10. Tucci J, Alhushki W, Chen T, Sheng X, Kim YM, Mittelman SD. Switch to low-fat diet improves outcome of acute lymphoblastic leukemia in obese mice. Cancer Metab. 2018; 6:15. PMID: 30410754.
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    11. Vidmar AP, Pretlow R, Borzutzky C, Wee CP, Fox DS, Fink C, Mittelman SD. An addiction model-based mobile health weight loss intervention in adolescents with obesity. Pediatr Obes. 2019 02; 14(2):e12464. PMID: 30117309.
      View in: PubMed
    12. Mittelman SD, Orgel E. Adipocyte metabolism of the chemotherapy daunorubicin. Oncoscience. 2018 May; 5(5-6):146-147. PMID: 30035170.
      View in: PubMed
    13. Prasca S, Carmona R, Ji L, Ko RH, Bhojwani D, Rawlins YA, Mittelman SD, Young G, Orgel E. Obesity and risk for venous thromboembolism from contemporary therapy for pediatric acute lymphoblastic leukemia. Thromb Res. 2018 05; 165:44-50. PMID: 29567586.
      View in: PubMed
    14. Dieli-Conwright CM, Parmentier JH, Sami N, Lee K, Spicer D, Mack WJ, Sattler F, Mittelman SD. Adipose tissue inflammation in breast cancer survivors: effects of a 16-week combined aerobic and resistance exercise training intervention. Breast Cancer Res Treat. 2018 Feb; 168(1):147-157. PMID: 29168064.
      View in: PubMed
    15. Sheng X, Parmentier JH, Tucci J, Pei H, Cortez-Toledo O, Dieli-Conwright CM, Oberley MJ, Neely M, Orgel E, Louie SG, Mittelman SD. Adipocytes Sequester and Metabolize the Chemotherapeutic Daunorubicin. Mol Cancer Res. 2017 12; 15(12):1704-1713. PMID: 29117945.
      View in: PubMed
    16. Maggi M, Mittelman SD, Parmentier JH, Colombo G, Meli M, Whitmire JM, Merrell DS, Whitelegge J, Scotti C. A protease-resistant Escherichia coli asparaginase with outstanding stability and enhanced anti-leukaemic activity in vitro. Sci Rep. 2017 11 03; 7(1):14479. PMID: 29101342.
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    17. Orgel E, Mueske NM, Sposto R, Gilsanz V, Wren TAL, Freyer DR, Butturini AM, Mittelman SD. A randomized controlled trial testing an adherence-optimized Vitamin D regimen to mitigate bone change in adolescents being treated for acute lymphoblastic leukemia. Leuk Lymphoma. 2017 Oct; 58(10):2370-2378. PMID: 28278717.
      View in: PubMed
    18. Sheng X, Tucci J, Parmentier JH, Ji L, Behan JW, Heisterkamp N, Mittelman SD. Adipocytes cause leukemia cell resistance to daunorubicin via oxidative stress response. Oncotarget. 2016 Nov 08; 7(45):73147-73159. PMID: 27705905.
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    19. Salehi P, Hsu I, Azen CG, Mittelman SD, Geffner ME, Jeandron D. Effects of exenatide on weight and appetite in overweight adolescents and young adults with Prader-Willi syndrome. Pediatr Obes. 2017 06; 12(3):221-228. PMID: 27071367.
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    20. Orgel E, Mueske NM, Wren TA, Gilsanz V, Butturini AM, Freyer DR, Mittelman SD. Early injury to cortical and cancellous bone from induction chemotherapy for adolescents and young adults treated for acute lymphoblastic leukemia. Bone. 2016 Apr; 85:131-7. PMID: 26851412.
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    21. Orgel E, Mueske NM, Sposto R, Gilsanz V, Freyer DR, Mittelman SD. Limitations of body mass index to assess body composition due to sarcopenic obesity during leukemia therapy. Leuk Lymphoma. 2018 01; 59(1):138-145. PMID: 26818609.
      View in: PubMed
    22. Van Speybroeck A, Mueske NM, Mittelman SD, Kremer RK, Ryan DD, Wren TA. Fasting serum blood measures of bone and lipid metabolism in children with myelomeningocele for early detection of cardiovascular and bone fragility risk factors. J Spinal Cord Med. 2017 03; 40(2):193-200. PMID: 26666357.
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    23. Kim MS, Ryabets-Lienhard A, Dao-Tran A, Mittelman SD, Gilsanz V, Schrager SM, Geffner ME. Increased Abdominal Adiposity in Adolescents and Young Adults With Classical Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency. J Clin Endocrinol Metab. 2015 Aug; 100(8):E1153-9. PMID: 26062016.
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    24. Lin MH, Wood JR, Mittelman SD, Freyer DR. Institutional adherence to cardiovascular risk factor screening guidelines for young survivors of acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 2015 May; 37(4):e253-7. PMID: 25757021.
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    25. Parmentier JH, Maggi M, Tarasco E, Scotti C, Avramis VI, Mittelman SD. Glutaminase activity determines cytotoxicity of L-asparaginases on most leukemia cell lines. Leuk Res. 2015 Jul; 39(7):757-62. PMID: 25941002.
      View in: PubMed
    26. McConnell R, Gilliland FD, Goran M, Allayee H, Hricko A, Mittelman S. Does near-roadway air pollution contribute to childhood obesity? Pediatr Obes. 2016 Feb; 11(1):1-3. PMID: 25820202.
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    27. Alderete TL, Sattler FR, Richey JM, Allayee H, Mittelman SD, Sheng X, Tucci J, Gyllenhammer LE, Grant EG, Goran MI. Salsalate treatment improves glycemia without altering adipose tissue in nondiabetic obese hispanics. Obesity (Silver Spring). 2015 Mar; 23(3):543-51. PMID: 25644856.
      View in: PubMed
    28. Huang KE, Mittelman SD, Coates TD, Geffner ME, Wood JC. A significant proportion of thalassemia major patients have adrenal insufficiency detectable on provocative testing. J Pediatr Hematol Oncol. 2015 Jan; 37(1):54-9. PMID: 24942024.
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    29. Shih EM, Mittelman S, Pitukcheewanont P, Azen CG, Monzavi R. Effects of vitamin D repletion on glycemic control and inflammatory cytokines in adolescents with type 1 diabetes. Pediatr Diabetes. 2016 Feb; 17(1):36-43. PMID: 25524404.
      View in: PubMed
    30. Orgel E, Tucci J, Alhushki W, Malvar J, Sposto R, Fu CH, Freyer DR, Abdel-Azim H, Mittelman SD. Obesity is associated with residual leukemia following induction therapy for childhood B-precursor acute lymphoblastic leukemia. Blood. 2014 Dec 18; 124(26):3932-8. PMID: 25349177.
      View in: PubMed
    31. Sheng X, Mittelman SD. The role of adipose tissue and obesity in causing treatment resistance of acute lymphoblastic leukemia. Front Pediatr. 2014; 2:53. PMID: 24926474.
      View in: PubMed
    32. Alderete TL, Sattler FR, Sheng X, Tucci J, Mittelman SD, Grant EG, Goran MI. A novel biopsy method to increase yield of subcutaneous abdominal adipose tissue. Int J Obes (Lond). 2015 Jan; 39(1):183-6. PMID: 24849392.
      View in: PubMed
    33. Behan JW, Ehsanipour EA, Sheng X, Pramanik R, Wang X, Hsieh YT, Kim YM, Mittelman SD. Activation of adipose tissue macrophages in obese mice does not require lymphocytes. Obesity (Silver Spring). 2013 Jul; 21(7):1380-8. PMID: 23754826.
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    34. Sheng X, Tucci J, Malvar J, Mittelman SD. Adipocyte differentiation is affected by media height above the cell layer. Int J Obes (Lond). 2014 Feb; 38(2):315-20. PMID: 23743593.
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    35. Ehsanipour EA, Sheng X, Behan JW, Wang X, Butturini A, Avramis VI, Mittelman SD. Adipocytes cause leukemia cell resistance to L-asparaginase via release of glutamine. Cancer Res. 2013 May 15; 73(10):2998-3006. PMID: 23585457.
      View in: PubMed
    36. Orgel E, Mittelman SD. The links between insulin resistance, diabetes, and cancer. Curr Diab Rep. 2013 Apr; 13(2):213-22. PMID: 23271574.
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    37. Pramanik R, Sheng X, Ichihara B, Heisterkamp N, Mittelman SD. Adipose tissue attracts and protects acute lymphoblastic leukemia cells from chemotherapy. Leuk Res. 2013 May; 37(5):503-9. PMID: 23332453.
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    38. Lesser DJ, Bhatia R, Tran WH, Oliveira F, Ortega R, Keens TG, Mittelman SD, Khoo MC, Davidson Ward SL. Sleep fragmentation and intermittent hypoxemia are associated with decreased insulin sensitivity in obese adolescent Latino males. Pediatr Res. 2012 Sep; 72(3):293-8. PMID: 22669298.
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    39. Antony R, Sheng X, Ehsanipour EA, Ng E, Pramanik R, Klemm L, Ichihara B, Mittelman SD. Vitamin D protects acute lymphoblastic leukemia cells from dexamethasone. Leuk Res. 2012 May; 36(5):591-3. PMID: 22341429.
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    40. Noetzli LJ, Panigrahy A, Mittelman SD, Hyderi A, Dongelyan A, Coates TD, Wood JC. Pituitary iron and volume predict hypogonadism in transfusional iron overload. Am J Hematol. 2012 Feb; 87(2):167-71. PMID: 22213195.
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    41. Noetzli LJ, Mittelman SD, Watanabe RM, Coates TD, Wood JC. Pancreatic iron and glucose dysregulation in thalassemia major. Am J Hematol. 2012 Feb; 87(2):155-60. PMID: 22120775.
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    42. Reh CM, Mittelman SD, Wee CP, Shah AC, Kaufman FR, Wood JR. A longitudinal assessment of lipids in youth with type 1 diabetes. Pediatr Diabetes. 2011 Jun; 12(4 Pt 2):365-71. PMID: 21392191.
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    43. Chung SA, Dorey F, Mittelman S, Gilsanz V. Effect of gender on intra-abdominal fat in teenagers and young adults. Pediatr Radiol. 2011 Apr; 41(4):469-75. PMID: 21038077.
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    44. Yun JP, Behan JW, Heisterkamp N, Butturini A, Klemm L, Ji L, Groffen J, Müschen M, Mittelman SD. Diet-induced obesity accelerates acute lymphoblastic leukemia progression in two murine models. Cancer Prev Res (Phila). 2010 Oct; 3(10):1259-64. PMID: 20823291.
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    45. Wood JC, Noetzl L, Hyderi A, Joukar M, Coates T, Mittelman S. Predicting pituitary iron and endocrine dysfunction. Ann N Y Acad Sci. 2010 Aug; 1202:123-8. PMID: 20712782.
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    46. Mittelman SD, Klier K, Braun S, Azen C, Geffner ME, Buchanan TA. Obese adolescents show impaired meal responses of the appetite-regulating hormones ghrelin and PYY. Obesity (Silver Spring). 2010 May; 18(5):918-25. PMID: 20094039.
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    47. Behan JW, Avramis VI, Yun JP, Louie SG, Mittelman SD. Diet-induced obesity alters vincristine pharmacokinetics in blood and tissues of mice. Pharmacol Res. 2010 May; 61(5):385-90. PMID: 20083201.
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    48. Oliveira FM, Tran WH, Lesser D, Bhatia R, Ortega R, Mittelman SD, Keens TG, Davidson Ward SL, Khoo MC. Autonomic and metabolic effects of OSA in childhood obesity. Conf Proc IEEE Eng Med Biol Soc. 2010; 2010:6134-7. PMID: 21097142.
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    49. Mittelman SD, Gilsanz P, Mo AO, Wood J, Dorey F, Gilsanz V. Adiposity predicts carotid intima-media thickness in healthy children and adolescents. J Pediatr. 2010 Apr; 156(4):592-7.e2. PMID: 20004913.
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    50. Behan JW, Yun JP, Proektor MP, Ehsanipour EA, Arutyunyan A, Moses AS, Avramis VI, Louie SG, Butturini A, Heisterkamp N, Mittelman SD. Adipocytes impair leukemia treatment in mice. Cancer Res. 2009 Oct 01; 69(19):7867-74. PMID: 19773440.
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    51. Gilsanz V, Chalfant J, Mo AO, Lee DC, Dorey FJ, Mittelman SD. Reciprocal relations of subcutaneous and visceral fat to bone structure and strength. J Clin Endocrinol Metab. 2009 Sep; 94(9):3387-93. PMID: 19531595.
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    52. Di Iorgi N, Mittelman SD, Gilsanz V. Differential effect of marrow adiposity and visceral and subcutaneous fat on cardiovascular risk in young, healthy adults. Int J Obes (Lond). 2008 Dec; 32(12):1854-60. PMID: 18838978.
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    53. Di Iorgi N, Rosol M, Mittelman SD, Gilsanz V. Reciprocal relation between marrow adiposity and the amount of bone in the axial and appendicular skeleton of young adults. J Clin Endocrinol Metab. 2008 Jun; 93(6):2281-6. PMID: 18381577.
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    54. Karantza MV, Mittelman SD, Dorey F, Samie S, Kaiserman K, Halvorson M, Kaufman FR. Relationship of highly sensitive C-reactive protein and lipid levels in adolescents with type 1 diabetes mellitus. Pediatr Diabetes. 2008 Apr; 9(2):122-6. PMID: 18036131.
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    55. Janicka A, Wren TA, Sanchez MM, Dorey F, Kim PS, Mittelman SD, Gilsanz V. Fat mass is not beneficial to bone in adolescents and young adults. J Clin Endocrinol Metab. 2007 Jan; 92(1):143-7. PMID: 17047019.
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    56. Mittelman SD, Hendy GN, Fefferman RA, Canaff L, Mosesova I, Cole DE, Burkett L, Geffner ME. A hypocalcemic child with a novel activating mutation of the calcium-sensing receptor gene: successful treatment with recombinant human parathyroid hormone. J Clin Endocrinol Metab. 2006 Jul; 91(7):2474-9. PMID: 16608894.
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    57. Kovanlikaya A, Mittelman SD, Ward A, Geffner ME, Dorey F, Gilsanz V. Obesity and fat quantification in lean tissues using three-point Dixon MR imaging. Pediatr Radiol. 2005 Jun; 35(6):601-7. PMID: 15785930.
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    58. van Citters GW, Kabir M, Kim SP, Mittelman SD, Dea MK, Brubaker PL, Bergman RN. Elevated glucagon-like peptide-1-(7-36)-amide, but not glucose, associated with hyperinsulinemic compensation for fat feeding. J Clin Endocrinol Metab. 2002 Nov; 87(11):5191-8. PMID: 12414891.
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    59. Mittelman SD, Van Citters GW, Kirkman EL, Bergman RN. Extreme insulin resistance of the central adipose depot in vivo. Diabetes. 2002 Mar; 51(3):755-61. PMID: 11872676.
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    60. Fosgerau K, Mittelman SD, Sunehag A, Dea MK, Lundgren K, Bergman RN. Lack of hepatic "interregulation" during inhibition of glycogenolysis in a canine model. Am J Physiol Endocrinol Metab. 2001 Aug; 281(2):E375-83. PMID: 11440915.
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    61. Bergman RN, Van Citters GW, Mittelman SD, Dea MK, Hamilton-Wessler M, Kim SP, Ellmerer M. Central role of the adipocyte in the metabolic syndrome. J Investig Med. 2001 Jan; 49(1):119-26. PMID: 11217141.
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    62. Dea MK, Van Citters GW, Ader M, Mittelman SD, Sunehag AL, Bergman RN. Paradoxical effect of troglitazone in normal animals: enhancement of adipocyte but reduction of liver insulin sensitivity. Diabetes. 2000 Dec; 49(12):2087-93. PMID: 11118011.
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    63. Mittelman SD, Van Citters GW, Kim SP, Davis DA, Dea MK, Hamilton-Wessler M, Bergman RN. Longitudinal compensation for fat-induced insulin resistance includes reduced insulin clearance and enhanced beta-cell response. Diabetes. 2000 Dec; 49(12):2116-25. PMID: 11118015.
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    64. Mittelman SD, Bergman RN. Inhibition of lipolysis causes suppression of endogenous glucose production independent of changes in insulin. Am J Physiol Endocrinol Metab. 2000 Sep; 279(3):E630-7. PMID: 10950832.
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    65. Getty L, Panteleon AE, Mittelman SD, Dea MK, Bergman RN. Rapid oscillations in omental lipolysis are independent of changing insulin levels in vivo. J Clin Invest. 2000 Aug; 106(3):421-30. PMID: 10930445.
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    66. Carpentier A, Mittelman SD, Bergman RN, Giacca A, Lewis GF. Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes. Diabetes. 2000 Mar; 49(3):399-408. PMID: 10868961.
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    67. Carpentier A, Mittelman SD, Lamarche B, Bergman RN, Giacca A, Lewis GF. Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation. Am J Physiol. 1999 06; 276(6):E1055-66. PMID: 10362618.
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    68. Steil GM, Rebrin K, Mittelman SD, Bergman RN. Role of portal insulin delivery in the disappearance of intravenous glucose and assessment of insulin sensitivity. Diabetes. 1998 May; 47(5):714-20. PMID: 9588441.
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    69. Bergman RN, Mittelman SD. Central role of the adipocyte in insulin resistance. J Basic Clin Physiol Pharmacol. 1998; 9(2-4):205-21. PMID: 10212835.
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    70. Mittelman SD, Fu YY, Rebrin K, Steil G, Bergman RN. Indirect effect of insulin to suppress endogenous glucose production is dominant, even with hyperglucagonemia. J Clin Invest. 1997 Dec 15; 100(12):3121-30. PMID: 9399959.
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    71. Rebrin K, Steil GM, Mittelman SD, Bergman RN. Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs. J Clin Invest. 1996 Aug 01; 98(3):741-9. PMID: 8698866.
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