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Evan Dale Abel

Title(s)Department Chair, Medicine Dept.
SchoolMedicine
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    Other Positions
    Title(s)Professor, Medicine


    Collapse Research 
    Collapse research activities and funding
    Molecular Determinants of MG53 in Heart Structure and Function
    NIH R01HL157781Sep 10, 2021 - Aug 31, 2025
    Role: Principal Investigator
    Modulating ROS by Electromagnetic Fields to Treat Type 2 Diabetes
    NIH R01DK125079Apr 15, 2021 - Feb 28, 2026
    Role: Principal Investigator
    OPA1 an Estrogen-Mediated Modulator of Platelet Hyperactivation
    NIH R33HL141783Apr 10, 2018 - Mar 31, 2023
    Role: Principal Investigator
    OPA1 an Estrogen-Mediated Modulator of Platelet Hyperactivation
    NIH R61HL141783Apr 10, 2018 - Mar 31, 2020
    Role: Principal Investigator
    Diabetes Research Training Program
    NIH T32DK112751Jul 1, 2017 - Jun 30, 2022
    Role: Principal Investigator
    Cardiac Dysfunction in the Met Syndrome: Cross-talk between IR and bAR Signaling
    NIH R01HL112413Jun 1, 2015 - May 31, 2020
    Role: Principal Investigator
    Insulin Inhibition of beta-AR Signaling in the Myocardium
    NIH R01HL127764Apr 1, 2015 - Jan 31, 2020
    Role: Principal Investigator
    Future Leaders Advancing Research in Endocrinology (FLARE): Professional Development for Underrepresented Trainees and Junior Faculty
    NIH R25DK096937Aug 1, 2012 - Apr 30, 2023
    Role: Principal Investigator
    Functional Genomics of the Mitochondrial Proteome
    NIH R24DK092784Sep 30, 2011 - Sep 29, 2012
    Role: Principal Investigator
    Interdisciplinary Training Program in Metabolism
    NIH T32DK091317Jul 1, 2011 - Jun 30, 2026
    Role: Co-Principal Investigator
    Insulin Resistance and Myocardial Autophagy
    NIH R01HL108379Apr 1, 2011 - Mar 31, 2017
    Role: Principal Investigator
    University of Utah Biomedical Research Core Center (P30) in Metabolism and CVD
    NIH P30HL101310Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Modeling Diabetic Cardiomyopathy and Microangiopathy
    NIH U01HL087947Sep 4, 2006 - Aug 31, 2011
    Role: Principal Investigator
    Targeting Antioxidant Therapy to Cardiac Mitochondria
    NIH R21DK073590Sep 30, 2005 - Aug 31, 2007
    Role: Principal Investigator
    Insulin Signaling and the Heart in Diabetes
    NIH R01HL070070Feb 1, 2004 - Dec 31, 2008
    Role: Principal Investigator
    Insulin resistance and cardiac dysfunction in obesity
    NIH R01HL073167May 1, 2003 - Apr 30, 2009
    Role: Principal Investigator
    Insulin Signaling and the Heart in Diabetes
    NIH R01DK092065Apr 1, 2002 - Jun 30, 2013
    Role: Principal Investigator
    PHYSIOLOGICAL CONSEQUENCES OF ENHANCED GLUT4 EXPRESSION
    NIH R03DK058073Sep 1, 2000 - Aug 31, 2003
    Role: Principal Investigator
    THE ROLE OF GLUT4 IN THE PATHO OF DIABETIC CARDIOMYOPA
    NIH R21HL062886Sep 30, 1998 - Dec 31, 2000
    Role: Principal Investigator
    IN VIVO ANALYSIS OF THYROID HORMONE ACTION
    NIH K08DK002495May 1, 1997 - Apr 30, 2003
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Platelet mTOR Is a Regulator of Sterile Immunothrombosis. Arterioscler Thromb Vasc Biol. 2026 Mar 05. Denorme F, Portier I, Castro H, Ajanel A, Kosaka Y, Benzon H, De Araujo CV, Souvenir R, Abel ED, Weyrich AS, Rondina MT, Campbell RA. PMID: 41783929.
      View in: PubMed   Mentions:
    2. A Road Map to Understanding Cardiovascular Disease in Diabetes: From the AHA Strategically Focused Research Network in Cardiometabolic Health and Type 2 Diabetes. Circ Res. 2026 Jan 16; 138(2):e325798. Abel ED, Ahima RS, Anderson EJ, Berg DD, Berger JS, Das S, Feinberg MW, Fisher EA, Garshick MS, Giannarelli C, Goldberg IJ, Hamburg NM, Kim SF, Moura FA, Ndumele CE, Newman JD, Sabatine MS, Selvin E, Shah R. PMID: 41538415.
      View in: PubMed   Mentions:
    3. Mitochondrial oxidants promote platelet activation and thrombotic susceptibility in prediabetes. J Clin Invest. 2026 Feb 16; 136(4). Ahmed A, Yadav P, Jensen M, Geasland K, Swamy J, Spitz DR, Abel ED, Jalal D, Dayal S. PMID: 41433113; PMCID: PMC12904718.
      View in: PubMed   Mentions:
    4. Lysosomal LRRC8 complex impacts lysosomal pH, morphology, and systemic glucose metabolism. Sci Adv. 2025 Sep 26; 11(39):eadt6366. Kumar A, Zhao Y, Xie L, Chadda R, Tranter JD, Mikami RT, Abraham N, Hong J, Feng E, Rawnsley DR, Liu H, Henry KM, Meyer G, Hu M, Xu H, Hinton A, Grueter CE, Abel ED, Norris AW, Diwan A, Sah R. PMID: 41004571; PMCID: PMC12466849.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Cardiac sodium-glucose co-transporter 1 (SGLT1) contributes to heart failure in a mouse model of diabetic cardiomyopathy. Basic Res Cardiol. 2025 12; 120(6):1193-1207. Li Z, Freiberg S, Music ML, Gu L, Nacos S, Phillips JP, Hassan A, Shibbani K, Munir SS, Kumar VK, Halligan L, Michel ME, London BF, Bui N, Cicha M, Buffard V, Abel ED, Ahmad F. PMID: 40932483; PMCID: PMC12680731.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. Sex Differences in Ketogenic Diet Response Reveal Gonadal Hormone Interaction With FGF21 in Mice. J Endocr Soc. 2025 Oct; 9(10):bvaf131. Zhang Y, Cochran JD, Souvenir RA, Tai W, Xia R, Gladwin BS, Barton NB, Pereira RO, Abel ED. PMID: 40917105; PMCID: PMC12411846.
      View in: PubMed   Mentions: 1  
    7. Deletion of PTP1B in cardiomyocytes alters cardiac metabolic signaling to protect against cardiomyopathy induced by a high-fat diet. Sci Signal. 2025 07 22; 18(896):eadp6006. Sun Y, Mishra AK, Chanrasekhar V, Door M, Kessinger CW, Xu B, Tang P, Gao Y, Kamli-Salino S, Nelson K, Delibegovic M, Abel ED, Kirk JA, Kontaridis MI. PMID: 40694612; PMCID: PMC12445919.
      View in: PubMed   Mentions:
    8. Corrigendum to "Activation of IGF-1 receptors and Akt signaling by systemic hyperinsulinemia contributes to cardiac hypertrophy but does not regulate cardiac autophagy in obese diabetic mice" [Journal of Molecular and Cellular Cardiology 113 (2017) 39-50]. J Mol Cell Cardiol. 2025 Apr; 201:94. Pires KM, Buffolo M, Schaaf C, Symons JD, Cox J, Abel ED, Selzman CH, Boudina S. PMID: 40023116.
      View in: PubMed   Mentions:
    9. Author Correction: Oligodendroglial fatty acid metabolism as a central nervous system energy reserve. Nat Neurosci. 2024 Oct; 27(10):2046. Asadollahi E, Trevisiol A, Saab AS, Looser ZJ, Dibaj P, Ebrahimi R, Kusch K, Ruhwedel T, Möbius W, Jahn O, Lee JY, Don AS, Khalil MA, Hiller K, Baes M, Weber B, Abel ED, Ballabio A, Popko B, Kassmann CM, Ehrenreich H, Hirrlinger J, Nave KA. PMID: 39289565; PMCID: PMC11452335.
      View in: PubMed   Mentions:    Fields:    
    10. BATokines in metabolic liver disease: good cops or bad cops? EMBO J. 2024 Nov; 43(21):4807-4809. Pereira RO, Abel ED. PMID: 39322755; PMCID: PMC11535238.
      View in: PubMed   Mentions:    Fields:    
    11. IRS2 Signaling Protects Against Stress-Induced Arrhythmia by Maintaining Ca2+ Homeostasis. Circulation. 2024 Dec 10; 150(24):1966-1983. Shi Q, Wang J, Malik H, Li X, Streeter J, Sharafuddin J, Weatherford E, Stein D, Itan Y, Chen B, Hall D, Song LS, Abel ED. PMID: 39253856; PMCID: PMC11631690.
      View in: PubMed   Mentions:
    12. Oligodendroglial fatty acid metabolism as a central nervous system energy reserve. Nat Neurosci. 2024 Oct; 27(10):1934-1944. Asadollahi E, Trevisiol A, Saab AS, Looser ZJ, Dibaj P, Ebrahimi R, Kusch K, Ruhwedel T, Möbius W, Jahn O, Lee JY, Don AS, Khalil MA, Hiller K, Baes M, Weber B, Abel ED, Ballabio A, Popko B, Kassmann CM, Ehrenreich H, Hirrlinger J, Nave KA. PMID: 39251890; PMCID: PMC11452346.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    13. Diabetes mellitus-Progress and opportunities in the evolving epidemic. Cell. 2024 Jul 25; 187(15):3789-3820. Abel ED, Gloyn AL, Evans-Molina C, Joseph JJ, Misra S, Pajvani UB, Simcox J, Susztak K, Drucker DJ. PMID: 39059357; PMCID: PMC11299851.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    14. Comparative analysis of two independent Myh6-Cre transgenic mouse lines. J Mol Cell Cardiol Plus. 2024 Sep; 9. Davenport A, Kessinger CW, Pfeiffer RD, Shah N, Xu R, Abel ED, Tucker NR, Lin Z. PMID: 39323506; PMCID: PMC11423776.
      View in: PubMed   Mentions: 1  
    15. Myocardial infarction causes sex-dependent dysfunction in vagal sensory glutamatergic neurotransmission that is mitigated by 17β-estradiol. JCI Insight. 2024 Jun 17; 9(14). Devarajan A, Wang K, Lokhandwala ZA, Emamimeybodi M, Shannon K, Tompkins JD, Hevener AL, Lusis AJ, Abel ED, Vaseghi M. PMID: 38885308; PMCID: PMC11383359.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    16. Cardiac monoamine oxidase-A inhibition protects against catecholamine-induced ventricular arrhythmias via enhanced diastolic calcium control. Cardiovasc Res. 2024 05 07; 120(6):596-611. Shi Q, Malik H, Crawford RM, Streeter J, Wang J, Huo R, Shih JC, Chen B, Hall D, Abel ED, Song LS, Anderson EJ. PMID: 38198753; PMCID: PMC11074799.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    17. New Insights into IGF-1 Signaling in the Heart. Physiology (Bethesda). 2024 09 01; 39(5):0. Lee WS, Abel ED, Kim J. PMID: 38713091.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    18. Metabolic liability for weight gain in early adulthood. Cell Rep Med. 2024 May 21; 5(5):101548. Murthy VL, Mosley JD, Perry AS, Jacobs DR, Tanriverdi K, Zhao S, Sawicki KT, Carnethon M, Wilkins JT, Nayor M, Das S, Abel ED, Freedman JE, Clish CB, Shah RV. PMID: 38703763; PMCID: PMC11148768.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    19. ATF4-dependent increase in mitochondrial-endoplasmic reticulum tethering following OPA1 deletion in skeletal muscle. J Cell Physiol. 2024 04; 239(4):e31204. Hinton A, Katti P, Mungai M, Hall DD, Koval O, Shao J, Vue Z, Lopez EG, Rostami R, Neikirk K, Ponce J, Streeter J, Schickling B, Bacevac S, Grueter C, Marshall A, Beasley HK, Do Koo Y, Bodine SC, Nava NGR, Quintana AM, Song LS, Grumbach IM, Pereira RO, Glancy B, Abel ED. PMID: 38419397; PMCID: PMC11144302.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    20. Mitochondrial Dynamics, Diabetes, and Cardiovascular Disease. Diabetes. 2024 Feb 01; 73(2):151-161. García-Peña LM, Abel ED, Pereira RO. PMID: 38241507; PMCID: PMC10796300.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    21. Hypoxia Attenuates Pressure Overload-Induced Heart Failure. J Am Heart Assoc. 2024 Feb 06; 13(3):e033553. Froese N, Szaroszyk M, Galuppo P, Visker JR, Werlein C, Korf-Klingebiel M, Berliner D, Reboll MR, Hamouche R, Gegel S, Wang Y, Hofmann W, Tang M, Geffers R, Wende AR, Kühnel MP, Jonigk DD, Hansmann G, Wollert KC, Abel ED, Drakos SG, Bauersachs J, Riehle C. PMID: 38293923; PMCID: PMC11056135.
      View in: PubMed   Mentions:
    22. Control of NAD+ homeostasis by autophagic flux modulates mitochondrial and cardiac function. EMBO J. 2024 Feb; 43(3):362-390. Zhang Q, Li Z, Li Q, Trammell SA, Schmidt MS, Pires KM, Cai J, Zhang Y, Kenny H, Boudina S, Brenner C, Abel ED. PMID: 38212381; PMCID: PMC10897141.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    23. Diabetes Suppresses Glucose Uptake and Glycolysis in Macrophages. Circ Res. 2022 03 04; 130(5):779-781. Matsuura Y, Shimizu-Albergine M, Barnhart S, Kramer F, Hsu CC, Kothari V, Tang J, Gharib SA, Kanter JE, Abel ED, Tian R, Shao B, Bornfeldt KE. PMID: 35170337; PMCID: PMC8897241.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    24. Perinatal versus adult loss of ULK1 and ULK2 distinctly influences cardiac autophagy and function. Autophagy. 2022 09; 18(9):2161-2177. Harris MP, Zhang QJ, Cochran CT, Ponce J, Alexander S, Kronemberger A, Fuqua JD, Zhang Y, Fattal R, Harper T, Murry ML, Grueter CE, Abel ED, Lira VA. PMID: 35104184; PMCID: PMC9466614.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    25. Protocols for Generating Surfaces and Measuring 3D Organelle Morphology Using Amira. Cells. 2021 12 27; 11(1). Garza-Lopez E, Vue Z, Katti P, Neikirk K, Biete M, Lam J, Beasley HK, Marshall AG, Rodman TA, Christensen TA, Salisbury JL, Vang L, Mungai M, AshShareef S, Murray SA, Shao J, Streeter J, Glancy B, Pereira RO, Abel ED, Hinton A. PMID: 35011629; PMCID: PMC8750564.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    26. Calpain-2 specifically cleaves Junctophilin-2 at the same site as Calpain-1 but with less efficacy. Biochem J. 2021 10 15; 478(19):3539-3553. Wang J, Ciampa G, Zheng D, Shi Q, Chen B, Abel ED, Peng T, Hall DD, Song LS. PMID: 34524407; PMCID: PMC8589432.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    27. Skeletal muscle type-specific mitochondrial adaptation to high-fat diet relies on differential autophagy modulation. FASEB J. 2021 10; 35(10):e21933. Morales PE, Monsalves-Álvarez M, Tadinada SM, Harris MP, Ramírez-Sagredo A, Ortiz-Quintero J, Troncoso MF, De Gregorio N, Calle X, Pereira RO, Lira VA, Espinosa A, Abel ED, Lavandero S. PMID: 34555201.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    28. Insulin and IGF-1 receptors regulate complex I-dependent mitochondrial bioenergetics and supercomplexes via FoxOs in muscle. J Clin Invest. 2021 09 15; 131(18). Bhardwaj G, Penniman CM, Jena J, Suarez Beltran PA, Foster C, Poro K, Junck TL, Hinton AO, Souvenir R, Fuqua JD, Morales PE, Bravo-Sagua R, Sivitz WI, Lira VA, Abel ED, O'Neill BT. PMID: 34343133; PMCID: PMC8439595.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    29. Functional resilience of C57BL/6J mouse heart to dietary fat overload. Am J Physiol Heart Circ Physiol. 2021 11 01; 321(5):H850-H864. Tadinada SM, Weatherford ET, Collins GV, Bhardwaj G, Cochran J, Kutschke W, Zimmerman K, Bosko A, O'Neill BT, Weiss RM, Abel ED. PMID: 34477461; PMCID: PMC8616610.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    30. A Universal Approach to Analyzing Transmission Electron Microscopy with ImageJ. Cells. 2021 08 24; 10(9). Lam J, Katti P, Biete M, Mungai M, AshShareef S, Neikirk K, Garza Lopez E, Vue Z, Christensen TA, Beasley HK, Rodman TA, Murray SA, Salisbury JL, Glancy B, Shao J, Pereira RO, Abel ED, Hinton A. PMID: 34571826; PMCID: PMC8465115.
      View in: PubMed   Mentions: 156     Fields:    Translation:AnimalsCells
    31. Insulin signaling in the heart. Am J Physiol Endocrinol Metab. 2021 07 01; 321(1):E130-E145. Abel ED. PMID: 34056923; PMCID: PMC8321827.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    32. Cardiac Energy Metabolism in Heart Failure. Circ Res. 2021 05 14; 128(10):1487-1513. Lopaschuk GD, Karwi QG, Tian R, Wende AR, Abel ED. PMID: 33983836; PMCID: PMC8136750.
      View in: PubMed   Mentions: 625     Fields:    Translation:HumansCells
    33. OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21. Elife. 2021 05 04; 10. Pereira RO, Marti A, Olvera AC, Tadinada SM, Bjorkman SH, Weatherford ET, Morgan DA, Westphal M, Patel PH, Kirby AK, Hewezi R, Bùi Trân W, García-Peña LM, Souvenir RA, Mittal M, Adams CM, Rahmouni K, Potthoff MJ, Abel ED. PMID: 33944779; PMCID: PMC8128440.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    34. Therapeutic potential of targeting oxidative stress in diabetic cardiomyopathy. Free Radic Biol Med. 2021 06; 169:317-342. Byrne NJ, Rajasekaran NS, Abel ED, Bugger H. PMID: 33910093; PMCID: PMC8285002.
      View in: PubMed   Mentions: 79     Fields:    Translation:Humans
    35. Reply to Petersen et al.: An alternative hypothesis for why exposure to static magnetic and electric fields treats type 2 diabetes. Am J Physiol Endocrinol Metab. 2021 05 01; 320(5):E1004-E1005. Carter CS, Huang SC, Searby CC, Cassaidy B, Miller MJ, Grzesik WJ, Piorczynski TB, Pak TK, Walsh SA, Acevedo M, Zhang Q, Mapuskar KA, Milne GL, Hinton AO, Guo DF, Weiss R, Bradberry K, Taylor EB, Rauckhorst AJ, Dick DW, Akurathi V, Falls-Hubert KC, Wagner BA, Carter WA, Wang K, Norris AW, Rahmouni K, Buettner GR, Hansen JM, Spitz DR, Abel ED, Sheffield VC. PMID: 33843283; PMCID: PMC8238129.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    36. Counterpoint: An alternative hypothesis for why exposure to static magnetic and electric fields treats type 2 diabetes. Am J Physiol Endocrinol Metab. 2021 05 01; 320(5):E1001-E1002. Carter CS, Huang SC, Searby CC, Cassaidy B, Miller MJ, Grzesik WJ, Piorczynski TB, Pak TK, Walsh SA, Acevedo M, Zhang Q, Mapuskar KA, Milne GL, Hinton AO, Guo DF, Weiss R, Bradberry K, Taylor EB, Rauckhorst AJ, Dick DW, Akurathi V, Falls-Hubert KC, Wagner BA, Carter WA, Wang K, Norris AW, Rahmouni K, Buettner GR, Hansen JM, Spitz DR, Abel ED, Sheffield VC. PMID: 33843282; PMCID: PMC8238130.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    37. GLUT1 Expression in Tumor-Associated Neutrophils Promotes Lung Cancer Growth and Resistance to Radiotherapy. Cancer Res. 2021 05 01; 81(9):2345-2357. Ancey PB, Contat C, Boivin G, Sabatino S, Pascual J, Zangger N, Perentes JY, Peters S, Abel ED, Kirsch DG, Rathmell JC, Vozenin MC, Meylan E. PMID: 33753374; PMCID: PMC8137580.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansAnimalsCells
    38. mTOR Mediated Metabolic Rewiring and Ischemic Preconditioning, its Complicated. Circ Res. 2021 03 05; 128(5):652-654. Abel ED. PMID: 34219792; PMCID: PMC8244748.
      View in: PubMed   Mentions: 3     Fields:    
    39. FoxO1 is required for physiological cardiac hypertrophy induced by exercise but not by constitutively active PI3K. Am J Physiol Heart Circ Physiol. 2021 04 01; 320(4):H1470-H1485. Weeks KL, Tham YK, Yildiz SG, Alexander Y, Donner DG, Kiriazis H, Harmawan CA, Hsu A, Bernardo BC, Matsumoto A, DePinho RA, Abel ED, Woodcock EA, McMullen JR. PMID: 33577435.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    40. An early endothelial cell-specific requirement for Glut1 is revealed in Glut1 deficiency syndrome model mice. JCI Insight. 2021 02 08; 6(3). Tang M, Park SH, Petri S, Yu H, Rueda CB, Abel ED, Kim CY, Hillman EM, Li F, Lee Y, Ding L, Jagadish S, Frankel WN, De Vivo DC, Monani UR. PMID: 33351789; PMCID: PMC7934852.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    41. It takes a village: lessons from collaborative science. J Clin Invest. 2021 01 19; 131(2). Abel ED. PMID: 33463544; PMCID: PMC7810490.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    42. Publisher Correction: Mitochondrial pyruvate carriers are required for myocardial stress adaptation. Nat Metab. 2020 Dec; 2(12):1498. Zhang Y, Taufalele PV, Cochran JD, Robillard-Frayne I, Marx JM, Soto J, Rauckhorst AJ, Tayyari F, Pewa AD, Gray LR, Teesch LM, Puchalska P, Funari TR, McGlauflin R, Zimmerman K, Kutschke WJ, Cassier T, Hitchcock S, Lin K, Kato KM, Stueve JL, Haff L, Weiss RM, Cox JE, Rutter J, Taylor EB, Crawford PA, Lewandowski ED, Des Rosiers C, Abel ED. PMID: 33208925.
      View in: PubMed   Mentions: 1     Fields:    
    43. Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes. Cell Metab. 2020 Dec 01; 32(6):1076. Carter CS, Huang SC, Searby CC, Cassaidy B, Miller MJ, Grzesik WJ, Piorczynski TB, Pak TK, Walsh SA, Acevedo M, Zhang Q, Mapuskar KA, Milne GL, Hinton AO, Guo DF, Weiss R, Bradberry K, Taylor EB, Rauckhorst AJ, Dick DW, Akurathi V, Falls-Hubert KC, Wagner BA, Carter WA, Wang K, Norris AW, Rahmouni K, Buettner GR, Hansen JM, Spitz DR, Abel ED, Sheffield VC. PMID: 33264599.
      View in: PubMed   Mentions: 5     Fields:    
    44. Mitochondrial pyruvate carriers are required for myocardial stress adaptation. Nat Metab. 2020 11; 2(11):1248-1264. Zhang Y, Taufalele PV, Cochran JD, Robillard-Frayne I, Marx JM, Soto J, Rauckhorst AJ, Tayyari F, Pewa AD, Gray LR, Teesch LM, Puchalska P, Funari TR, McGlauflin R, Zimmerman K, Kutschke WJ, Cassier T, Hitchcock S, Lin K, Kato KM, Stueve JL, Haff L, Weiss RM, Cox JE, Rutter J, Taylor EB, Crawford PA, Lewandowski ED, Des Rosiers C, Abel ED. PMID: 33106689; PMCID: PMC8015649.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    45. Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes. Cell Metab. 2020 10 06; 32(4):561-574.e7. Carter CS, Huang SC, Searby CC, Cassaidy B, Miller MJ, Grzesik WJ, Piorczynski TB, Pak TK, Walsh SA, Acevedo M, Zhang Q, Mapuskar KA, Milne GL, Hinton AO, Guo DF, Weiss R, Bradberry K, Taylor EB, Rauckhorst AJ, Dick DW, Akurathi V, Falls-Hubert KC, Wagner BA, Carter WA, Wang K, Norris AW, Rahmouni K, Buettner GR, Hansen JM, Spitz DR, Abel ED, Sheffield VC. PMID: 33027675; PMCID: PMC7819711.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    46. SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism. Elife. 2020 09 15; 9. Kumar A, Xie L, Ta CM, Hinton AO, Gunasekar SK, Minerath RA, Shen K, Maurer JM, Grueter CE, Abel ED, Meyer G, Sah R. PMID: 32930093; PMCID: PMC7541086.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    47. Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization. J Am Heart Assoc. 2020 08 04; 9(15):e013039. Brahma MK, Ha CM, Pepin ME, Mia S, Sun Z, Chatham JC, Habegger KM, Abel ED, Paterson AJ, Young ME, Wende AR. PMID: 32750298; PMCID: PMC7792234.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    48. Both aerobic glycolysis and mitochondrial respiration are required for osteoclast differentiation. FASEB J. 2020 08; 34(8):11058-11067. Li B, Lee WC, Song C, Ye L, Abel ED, Long F. PMID: 32627870.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    49. Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth. Elife. 2020 06 23; 9. Contat C, Ancey PB, Zangger N, Sabatino S, Pascual J, Escrig S, Jensen L, Goepfert C, Lanz B, Lepore M, Gruetter R, Rossier A, Berezowska S, Neppl C, Zlobec I, Clerc-Rosset S, Knott GW, Rathmell JC, Abel ED, Meibom A, Meylan E. PMID: 32571479; PMCID: PMC7311173.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    50. Reductive Stress Causes Pathological Cardiac Remodeling and Diastolic Dysfunction. Antioxid Redox Signal. 2020 06; 32(18):1293-1312. Shanmugam G, Wang D, Gounder SS, Fernandes J, Litovsky SH, Whitehead K, Radhakrishnan RK, Franklin S, Hoidal JR, Kensler TW, Dell'Italia L, Darley-Usmar V, Abel ED, Jones DP, Ping P, Rajasekaran NS. PMID: 32064894; PMCID: PMC7247052.
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    51. Basic Mechanisms of Diabetic Heart Disease. Circ Res. 2020 05 22; 126(11):1501-1525. Ritchie RH, Abel ED. PMID: 32437308; PMCID: PMC7251974.
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    52. Role of the GLUT1 Glucose Transporter in Postnatal CNS Angiogenesis and Blood-Brain Barrier Integrity. Circ Res. 2020 07 31; 127(4):466-482. Veys K, Fan Z, Ghobrial M, Bouché A, García-Caballero M, Vriens K, Conchinha NV, Seuwen A, Schlegel F, Gorski T, Crabbé M, Gilardoni P, Ardicoglu R, Schaffenrath J, Casteels C, De Smet G, Smolders I, Van Laere K, Abel ED, Fendt SM, Schroeter A, Kalucka J, Cantelmo AR, Wälchli T, Keller A, Carmeliet P, De Bock K. PMID: 32404031; PMCID: PMC7386868.
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    53. Maintaining Myocardial Glucose Utilization in Diabetic Cardiomyopathy Accelerates Mitochondrial Dysfunction. Diabetes. 2020 10; 69(10):2094-2111. Wende AR, Schell JC, Ha CM, Pepin ME, Khalimonchuk O, Schwertz H, Pereira RO, Brahma MK, Tuinei J, Contreras-Ferrat A, Wang L, Andrizzi CA, Olsen CD, Bradley WE, Dell'Italia LJ, Dillmann WH, Litwin SE, Abel ED. PMID: 32366681; PMCID: PMC7506832.
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    54. The Role of Nonglycolytic Glucose Metabolism in Myocardial Recovery Upon Mechanical Unloading and Circulatory Support in Chronic Heart Failure. Circulation. 2020 07 21; 142(3):259-274. Badolia R, Ramadurai DKA, Abel ED, Ferrin P, Taleb I, Shankar TS, Krokidi AT, Navankasattusas S, McKellar SH, Yin M, Kfoury AG, Wever-Pinzon O, Fang JC, Selzman CH, Chaudhuri D, Rutter J, Drakos SG. PMID: 32351122; PMCID: PMC7380956.
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    55. Stress-Induced Cyclin C Translocation Regulates Cardiac Mitochondrial Dynamics. J Am Heart Assoc. 2020 04 07; 9(7):e014366. Ponce JM, Coen G, Spitler KM, Dragisic N, Martins I, Hinton A, Mungai M, Tadinada SM, Zhang H, Oudit GY, Song LS, Li N, Sicinski P, Strack S, Abel ED, Mitchell C, Hall DD, Grueter CE. PMID: 32248761; PMCID: PMC7428645.
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    56. Insulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodeling. JCI Insight. 2020 03 26; 5(6). Riehle C, Weatherford ET, Wende AR, Jaishy BP, Seei AW, McCarty NS, Rech M, Shi Q, Reddy GR, Kutschke WJ, Oliveira K, Pires KM, Anderson JC, Diakos NA, Weiss RM, White MF, Drakos SG, Xiang YK, Xiang YK, Abel ED. PMID: 32213702; PMCID: PMC7213803.
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    57. Autophagy Reprograms Alveolar Progenitor Cell Metabolism in Response to Lung Injury. Stem Cell Reports. 2020 03 10; 14(3):420-432. Li X, Wu J, Sun X, Wu Q, Li Y, Li K, Zhang Q, Li Y, Abel ED, Chen H. PMID: 32059792; PMCID: PMC7066233.
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    58. Airway epithelial regeneration requires autophagy and glucose metabolism. Cell Death Dis. 2019 11 20; 10(12):875. Li K, Li M, Li W, Yu H, Sun X, Zhang Q, Li Y, Li X, Li Y, Abel ED, Wu Q, Chen H. PMID: 31748541; PMCID: PMC6868131.
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    59. p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas. Cell Rep. 2019 08 13; 28(7):1860-1878.e9. Hsieh MH, Choe JH, Gadhvi J, Kim YJ, Arguez MA, Palmer M, Gerold H, Nowak C, Do H, Mazambani S, Knighton JK, Cha M, Goodwin J, Kang MK, Jeong JY, Lee SY, Faubert B, Xuan Z, Abel ED, Scafoglio C, Shackelford DB, Minna JD, Singh PK, Shulaev V, Bleris L, Hoyt K, Kim J, Inoue M, DeBerardinis RJ, Kim TH, Kim JW. PMID: 31412252; PMCID: PMC7048935.
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    60. Loss of MCU prevents mitochondrial fusion in G1-S phase and blocks cell cycle progression and proliferation. Sci Signal. 2019 04 30; 12(579). Koval OM, Nguyen EK, Santhana V, Fidler TP, Sebag SC, Rasmussen TP, Mittauer DJ, Strack S, Goswami PC, Abel ED, Grumbach IM. PMID: 31040260; PMCID: PMC6768401.
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    61. Comparison of the Effects of High-Fat Diet on Energy Flux in Mice Using Two Multiplexed Metabolic Phenotyping Systems. Obesity (Silver Spring). 2019 05; 27(5):793-802. Soto JE, Burnett CML, Ten Eyck P, Abel ED, Grobe JL. PMID: 30938081; PMCID: PMC6478533.
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    62. Increased glycolysis mediates Wnt7b-induced bone formation. FASEB J. 2019 07; 33(7):7810-7821. Chen H, Ji X, Lee WC, Shi Y, Li B, Abel ED, Jiang D, Huang W, Long F. PMID: 30913395; PMCID: PMC6593878.
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    63. Glucose Metabolism Is Required for Platelet Hyperactivation in a Murine Model of Type 1 Diabetes. Diabetes. 2019 05; 68(5):932-938. Fidler TP, Marti A, Gerth K, Middleton EA, Campbell RA, Rondina MT, Weyrich AS, Abel ED. PMID: 30765335; PMCID: PMC6477909.
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    64. Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1. J Immunol. 2019 02 15; 202(4):1265-1286. Freemerman AJ, Zhao L, Pingili AK, Teng B, Cozzo AJ, Fuller AM, Johnson AR, Milner JJ, Lim MF, Galanko JA, Beck MA, Bear JE, Rotty JD, Bezavada L, Smallwood HS, Puchowicz MA, Liu J, Locasale JW, Lee DP, Bennett BJ, Abel ED, Rathmell JC, Makowski L. PMID: 30659108; PMCID: PMC6360258.
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    65. Heart Failure in Type 2 Diabetes Mellitus. Circ Res. 2019 01 04; 124(1):121-141. Kenny HC, Abel ED. PMID: 30605420; PMCID: PMC6447311.
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    66. Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure. Circ Res. 2019 01 04; 124(1):161-169. Berry JL, Zhu W, Tang YL, Krishnamurthy P, Ge Y, Cooke JP, Chen Y, Garry DJ, Yang HT, Rajasekaran NS, Koch WJ, Li S, Domae K, Qin G, Cheng K, Kamp TJ, Ye L, Hu S, Ogle BM, Rogers JM, Abel ED, Davis ME, Prabhu SD, Liao R, Pu WT, Wang Y, Ping P, Bursac N, Vunjak-Novakovic G, Wu JC, Bolli R, Menasché P, Zhang J. PMID: 30605412; PMCID: PMC6350935.
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    67. Modulating GLUT1 expression in retinal pigment epithelium decreases glucose levels in the retina: impact on photoreceptors and Müller glial cells. Am J Physiol Cell Physiol. 2019 01 01; 316(1):C121-C133. Swarup A, Samuels IS, Bell BA, Han JYS, Du J, Massenzio E, Abel ED, Boesze-Battaglia K, Peachey NS, Philp NJ. PMID: 30462537; PMCID: PMC6383144.
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    68. Glucose metabolism induced by Bmp signaling is essential for murine skeletal development. Nat Commun. 2018 11 16; 9(1):4831. Lee SY, Abel ED, Long F. PMID: 30446646; PMCID: PMC6240091.
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    69. Thyrocyte-specific deletion of insulin and IGF-1 receptors induces papillary thyroid carcinoma-like lesions through EGFR pathway activation. Int J Cancer. 2018 11 15; 143(10):2458-2469. Ock S, Ahn J, Lee SH, Kim HM, Kang H, Kim YK, Kook H, Park WJ, Kim S, Kimura S, Jung CK, Shong M, Holzenberger M, Abel ED, Lee TJ, Cho BY, Kim HS, Kim J. PMID: 30070361; PMCID: PMC6698377.
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    70. Effective Metabolic Approaches for the Energy Starved Failing Heart: Bioenergetic Resiliency via Redundancy or Something Else? Circ Res. 2018 07 20; 123(3):329-331. Zhang J, Abel ED. PMID: 30026379; PMCID: PMC6055933.
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    71. Prorenin independently causes hypertension and renal and cardiac fibrosis in cyp1a1-prorenin transgenic rats. Clin Sci (Lond). 2018 06 29; 132(12):1345-1363. Zhou G, Wu J, Gu C, Wang B, Abel ED, Cheung AK, Huang Y. PMID: 29848510; PMCID: PMC6024026.
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    72. Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis. Nat Med. 2018 05; 24(5):617-627. Zhang Z, Zi Z, Lee EE, Zhao J, Contreras DC, South AP, Abel ED, Chong BF, Vandergriff T, Hosler GA, Scherer PE, Mettlen M, Rathmell JC, DeBerardinis RJ, Wang RC. PMID: 29662201; PMCID: PMC6095711.
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    73. Deletion of GLUT1 in mouse lens epithelium leads to cataract formation. Exp Eye Res. 2018 07; 172:45-53. Swarup A, Bell BA, Du J, Han JYS, Soto J, Abel ED, Bravo-Nuevo A, FitzGerald PG, Peachey NS, Philp NJ. PMID: 29604281; PMCID: PMC6716165.
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    74. Connexin43 and zonula occludens-1 are targets of Akt in cardiomyocytes that correlate with cardiac contractile dysfunction in Akt deficient hearts. Biochim Biophys Acta Mol Basis Dis. 2018 Apr; 1864(4 Pt A):1183-1191. Ock S, Lee WS, Kim HM, Park KS, Kim YK, Kook H, Park WJ, Lee TJ, Abel ED, Kim J. PMID: 29378301; PMCID: PMC6342503.
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    75. MITOCHONDRIAL DYNAMICS AND METABOLIC REGULATION IN CARDIAC AND SKELETAL MUSCLE. Trans Am Clin Climatol Assoc. 2018; 129:266-278. Abel ED. PMID: 30166722; PMCID: PMC6116613.
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    76. Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation. JCI Insight. 2017 12 21; 2(24). Nabeebaccus AA, Zoccarato A, Hafstad AD, Santos CX, Aasum E, Brewer AC, Zhang M, Beretta M, Yin X, West JA, Schröder K, Griffin JL, Eykyn TR, Abel ED, Mayr M, Shah AM. PMID: 29263294; PMCID: PMC5752273.
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    77. Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function. Cell Rep. 2017 11 07; 21(6):1705. Fidler TP, Campbell RA, Funari T, Dunne N, Balderas Angeles E, Middleton EA, Chaudhuri D, Weyrich AS, Abel ED. PMID: 29117572; PMCID: PMC5700809.
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    78. Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induce Post-Translational Modifications of AKAP121, DRP1, and OPA1 That Promote Mitochondrial Fission. Circ Res. 2018 01 05; 122(1):58-73. Tsushima K, Bugger H, Wende AR, Soto J, Jenson GA, Tor AR, McGlauflin R, Kenny HC, Zhang Y, Souvenir R, Hu XX, Sloan CL, Pereira RO, Lira VA, Spitzer KW, Sharp TL, Shoghi KI, Sparagna GC, Rog-Zielinska EA, Kohl P, Khalimonchuk O, Schaffer JE, Abel ED. PMID: 29092894; PMCID: PMC5756120.
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    79. Activation of IGF-1 receptors and Akt signaling by systemic hyperinsulinemia contributes to cardiac hypertrophy but does not regulate cardiac autophagy in obese diabetic mice. J Mol Cell Cardiol. 2017 12; 113:39-50. Pires KM, Buffolo M, Schaaf C, David Symons J, Cox J, Abel ED, Selzman CH, Boudina S. PMID: 28987875; PMCID: PMC5689477.
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    80. Insulin-dependent metabolic and inotropic responses in the heart are modulated by hydrogen peroxide from NADPH-oxidase isoforms NOX2 and NOX4. Free Radic Biol Med. 2017 12; 113:16-25. Steinhorn B, Sartoretto JL, Sorrentino A, Romero N, Kalwa H, Abel ED, Michel T. PMID: 28917508; PMCID: PMC5699944.
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    81. Corrigendum: Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling. Nat Commun. 2017 08 30; 8:16155. Rines AK, Chang HC, Wu R, Sato T, Khechaduri A, Kouzu H, Shapiro J, Shang M, Burke MA, Abdelwahid E, Jiang X, Chen C, Rawlings TA, Lopaschuk GD, Schumacker PT, Abel ED, Ardehali H. PMID: 28853433; PMCID: PMC5582347.
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    82. Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function. Cell Rep. 2017 08 29; 20(9):2277. Fidler TP, Campbell RA, Funari T, Dunne N, Balderas Angeles E, Middleton EA, Chaudhuri D, Weyrch AS, Abel ED. PMID: 28854375.
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    83. Glucose transporter 4-deficient hearts develop maladaptive hypertrophy in response to physiological or pathological stresses. Am J Physiol Heart Circ Physiol. 2017 Dec 01; 313(6):H1098-H1108. Wende AR, Kim J, Holland WL, Wayment BE, O'Neill BT, Tuinei J, Brahma MK, Pepin ME, McCrory MA, Luptak I, Halade GV, Litwin SE, Abel ED. PMID: 28822962; PMCID: PMC5814656.
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    84. Superoxide Dismutase 2 is dispensable for platelet function. Thromb Haemost. 2017 10 05; 117(10):1859-1867. Fidler TP, Rowley JW, Araujo C, Boudreau LH, Marti A, Souvenir R, Dale K, Boilard E, Weyrich AS, Abel ED. PMID: 28771279; PMCID: PMC5894334.
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    85. DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging. Cell Metab. 2017 08 01; 26(2):447. Park SJ, Gavrilova O, Brown AL, Soto JE, Bremner S, Kim J, Xu X, Yang S, Um JH, Koch LG, Britton SL, Lieber RL, Philp A, Baar K, Kohama SG, Abel ED, Kim MK, Chung JH. PMID: 28768182.
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    87. Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heart. J Mol Cell Cardiol. 2017 09; 110:80-95. McGinnis GR, Tang Y, Brewer RA, Brahma MK, Stanley HL, Shanmugam G, Rajasekaran NS, Rowe GC, Frank SJ, Wende AR, Abel ED, Taegtmeyer H, Litovsky S, Darley-Usmar V, Zhang J, Chatham JC, Young ME. PMID: 28736261; PMCID: PMC5586500.
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    88. Glucose Transporter 3 Potentiates Degranulation and Is Required for Platelet Activation. Arterioscler Thromb Vasc Biol. 2017 09; 37(9):1628-1639. Fidler TP, Middleton EA, Rowley JW, Boudreau LH, Campbell RA, Souvenir R, Funari T, Tessandier N, Boilard E, Weyrich AS, Abel ED. PMID: 28663252; PMCID: PMC5570649.
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    89. Erratum: SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis. Nat Cell Biol. 2017 Jun 29; 19(7):873. Zhang Y, Xie L, Gunasekar SK, Tong D, Mishra A, Gibson WJ, Wang C, Fidler T, Marthaler B, Klingelhutz A, Abel ED, Samuel I, Smith JK, Cao L, Sah R. PMID: 28659636.
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    90. OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance. EMBO J. 2017 07 14; 36(14):2126-2145. Pereira RO, Tadinada SM, Zasadny FM, Oliveira KJ, Pires KMP, Olvera A, Jeffers J, Souvenir R, Mcglauflin R, Seei A, Funari T, Sesaki H, Potthoff MJ, Adams CM, Anderson EJ, Abel ED. PMID: 28607005; PMCID: PMC5510002.
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    91. Erratum: SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis. Nat Cell Biol. 2017 May 31; 19(6):740. Zhang Y, Xie L, Gunasekar SK, Tong D, Mishra A, Gibson WJ, Wang C, Fidler T, Marthaler B, Klingelhutz A, Abel ED, Samuel I, Smith JK, Cao L, Sah R. PMID: 28561048.
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    92. DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging. Cell Metab. 2017 May 02; 25(5):1135-1146.e7. Park SJ, Gavrilova O, Brown AL, Soto JE, Bremner S, Kim J, Xu X, Yang S, Um JH, Koch LG, Britton SL, Lieber RL, Philp A, Baar K, Kohama SG, Abel ED, Kim MK, Chung JH. PMID: 28467930; PMCID: PMC5485859.
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    93. SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis. Nat Cell Biol. 2017 05; 19(5):504-517. Zhang Y, Xie L, Gunasekar SK, Tong D, Mishra A, Gibson WJ, Wang C, Fidler T, Marthaler B, Klingelhutz A, Abel ED, Samuel I, Smith JK, Cao L, Sah R. PMID: 28436964; PMCID: PMC5415409.
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    94. Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling. Nat Commun. 2017 01 24; 8:14095. Rines AK, Chang HC, Wu R, Sato T, Khechaduri A, Kouzu H, Shapiro J, Shang M, Burke MA, Abdelwahid E, Jiang X, Chen C, Rawlings TA, Lopaschuk GD, Schumacker PT, Abel ED, Ardehali H. PMID: 28117339; PMCID: PMC5286102.
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    95. The glucose transporter GLUT1 is required for ErbB2-induced mammary tumorigenesis. Breast Cancer Res. 2016 12 20; 18(1):131. Wellberg EA, Johnson S, Finlay-Schultz J, Lewis AS, Terrell KL, Sartorius CA, Abel ED, Muller WJ, Anderson SM. PMID: 27998284; PMCID: PMC5168867.
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    96. Inhibiting Insulin-Mediated β2-Adrenergic Receptor Activation Prevents Diabetes-Associated Cardiac Dysfunction. Circulation. 2017 Jan 03; 135(1):73-88. Wang Q, Liu Y, Fu Q, Xu B, Zhang Y, Kim S, Tan R, Barbagallo F, West T, Anderson E, Wei W, Abel ED, Xiang YK, Xiang YK. PMID: 27815373; PMCID: PMC5302024.
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    97. Evidence of Glycolysis Up-Regulation and Pyruvate Mitochondrial Oxidation Mismatch During Mechanical Unloading of the Failing Human Heart: Implications for Cardiac Reloading and Conditioning. JACC Basic Transl Sci. 2016 Oct; 1(6):432-444. Diakos NA, Navankasattusas S, Abel ED, Rutter J, McCreath L, Ferrin P, McKellar SH, Miller DV, Park SY, Richardson RS, Deberardinis R, Cox JE, Kfoury AG, Selzman CH, Stehlik J, Fang JC, Li DY, Drakos SG. PMID: 28497127; PMCID: PMC5422992.
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    98. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat Commun. 2016 10 10; 7:12948. Trammell SA, Schmidt MS, Weidemann BJ, Redpath P, Jaksch F, Dellinger RW, Li Z, Abel ED, Migaud ME, Brenner C. PMID: 27721479; PMCID: PMC5062546.
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    99. Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis. J Clin Invest. 2016 09 01; 126(9):3433-46. O'Neill BT, Lee KY, Klaus K, Softic S, Krumpoch MT, Fentz J, Stanford KI, Robinson MM, Cai W, Kleinridders A, Pereira RO, Hirshman MF, Abel ED, Accili D, Goodyear LJ, Nair KS, Kahn CR. PMID: 27525440; PMCID: PMC5004956.
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    100. Lipids, lysosomes, and autophagy. J Lipid Res. 2016 09; 57(9):1619-35. Jaishy B, Abel ED. PMID: 27330054; PMCID: PMC5003162.
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    101. AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival. Cell Metab. 2016 Apr 12; 23(4):649-62. Kishton RJ, Barnes CE, Nichols AG, Cohen S, Gerriets VA, Siska PJ, Macintyre AN, Goraksha-Hicks P, de Cubas AA, Liu T, Warmoes MO, Abel ED, Yeoh AE, Gershon TR, Rathmell WK, Richards KL, Locasale JW, Rathmell JC. PMID: 27076078; PMCID: PMC4832577.
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    102. Insulin Signaling and Heart Failure. Circ Res. 2016 Apr 01; 118(7):1151-69. Riehle C, Abel ED. PMID: 27034277; PMCID: PMC4833475.
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    103. Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association. Circ Res. 2016 May 13; 118(10):1659-701. Taegtmeyer H, Young ME, Lopaschuk GD, Abel ED, Brunengraber H, Darley-Usmar V, Des Rosiers C, Gerszten R, Glatz JF, Griffin JL, Gropler RJ, Holzhuetter HG, Kizer JR, Lewandowski ED, Malloy CR, Neubauer S, Peterson LR, Portman MA, Recchia FA, Van Eyk JE, Wang TJ, American Heart Association Council on Basic Cardiovascular Sciences. PMID: 27012580; PMCID: PMC5130157.
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    104. Exercise training improves vascular mitochondrial function. Am J Physiol Heart Circ Physiol. 2016 Apr 01; 310(7):H821-9. Park SY, Rossman MJ, Gifford JR, Bharath LP, Bauersachs J, Richardson RS, Abel ED, Symons JD, Riehle C. PMID: 26825520; PMCID: PMC4867356.
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    105. Phosphoinositide dependent protein kinase 1 is required for exercise-induced cardiac hypertrophy but not the associated mitochondrial adaptations. J Mol Cell Cardiol. 2015 Dec; 89(Pt B):297-305. Noh J, Wende AR, Olsen CD, Kim B, Bevins J, Zhu Y, Zhang QJ, Riehle C, Abel ED. PMID: 26476238; PMCID: PMC4689617.
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    115. Enhanced cardiac Akt/protein kinase B signaling contributes to pathological cardiac hypertrophy in part by impairing mitochondrial function via transcriptional repression of mitochondrion-targeted nuclear genes. Mol Cell Biol. 2015 Mar; 35(5):831-46. Wende AR, O'Neill BT, Bugger H, Riehle C, Tuinei J, Buchanan J, Tsushima K, Wang L, Caro P, Guo A, Sloan C, Kim BJ, Wang X, Pereira RO, McCrory MA, Nye BG, Benavides GA, Darley-Usmar VM, Shioi T, Weimer BC, Abel ED. PMID: 25535334; PMCID: PMC4323486.
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    120. The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. Cell Metab. 2014 Jul 01; 20(1):61-72. Macintyre AN, Gerriets VA, Nichols AG, Michalek RD, Rudolph MC, Deoliveira D, Anderson SM, Abel ED, Chen BJ, Hale LP, Rathmell JC. PMID: 24930970; PMCID: PMC4079750.
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    121. Maintaining PGC-1α expression following pressure overload-induced cardiac hypertrophy preserves angiogenesis but not contractile or mitochondrial function. FASEB J. 2014 Aug; 28(8):3691-702. Pereira RO, Wende AR, Crum A, Hunter D, Olsen CD, Rawlings T, Riehle C, Ward WF, Abel ED. PMID: 24776744; PMCID: PMC4101649.
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    122. Time to look back and to look forward. Diabetes. 2014 Apr; 63(4):1169-70. Nair KS, Abel ED, Adler SG, Dyck PJ, Gardner TW, Haskins KM, Hotamisligil G, Jensen MD, Krook A, Mandarino LJ, Mitchell BD, Pessin JE, Sowers JR, Sussel L, Wareham N, Vella A. PMID: 24651796.
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    123. Insulin inhibits cardiac contractility by inducing a Gi-biased β2-adrenergic signaling in hearts. Diabetes. 2014 Aug; 63(8):2676-89. Fu Q, Xu B, Liu Y, Parikh D, Li J, Li Y, Zhang Y, Riehle C, Zhu Y, Rawlings T, Shi Q, Clark RB, Chen X, Abel ED, Xiang YK, Xiang YK. PMID: 24677713; PMCID: PMC4113065.
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    124. Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells. J Immunol. 2014 Apr 15; 192(8):3626-36. Caro-Maldonado A, Wang R, Nichols AG, Kuraoka M, Milasta S, Sun LD, Gavin AL, Abel ED, Kelsoe G, Green DR, Rathmell JC. PMID: 24616478; PMCID: PMC3984038.
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    127. The absence of insulin signaling in the heart induces changes in potassium channel expression and ventricular repolarization. Am J Physiol Heart Circ Physiol. 2014 Mar 01; 306(5):H747-54. Lopez-Izquierdo A, Pereira RO, Wende AR, Punske BB, Abel ED, Tristani-Firouzi M. PMID: 24375641; PMCID: PMC3949065.
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    128. Insulin receptor substrate signaling suppresses neonatal autophagy in the heart. J Clin Invest. 2013 Dec; 123(12):5319-33. Riehle C, Wende AR, Sena S, Pires KM, Pereira RO, Zhu Y, Bugger H, Frank D, Bevins J, Chen D, Perry CN, Dong XC, Valdez S, Rech M, Sheng X, Weimer BC, Gottlieb RA, White MF, Abel ED. PMID: 24177427; PMCID: PMC3859408.
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    129. Podocyte-specific GLUT4-deficient mice have fewer and larger podocytes and are protected from diabetic nephropathy. Diabetes. 2014 Feb; 63(2):701-14. Guzman J, Jauregui AN, Merscher-Gomez S, Maiguel D, Muresan C, Mitrofanova A, Diez-Sampedro A, Szust J, Yoo TH, Villarreal R, Pedigo C, Molano RD, Johnson K, Kahn B, Hartleben B, Huber TB, Saha J, Burke GW, Abel ED, Brosius FC, Fornoni A. PMID: 24101677; PMCID: PMC3900538.
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    130. Inducible overexpression of GLUT1 prevents mitochondrial dysfunction and attenuates structural remodeling in pressure overload but does not prevent left ventricular dysfunction. J Am Heart Assoc. 2013 Sep 19; 2(5):e000301. Pereira RO, Wende AR, Olsen C, Soto J, Rawlings T, Zhu Y, Anderson SM, Abel ED. PMID: 24052497; PMCID: PMC3835233.
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    131. Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the Akt-mTOR-NFκB-Opa-1 signaling pathway. Diabetes. 2014 Jan; 63(1):75-88. Parra V, Verdejo HE, Iglewski M, Del Campo A, Troncoso R, Jones D, Zhu Y, Kuzmicic J, Pennanen C, Lopez-Crisosto C, Jaña F, Ferreira J, Noguera E, Chiong M, Bernlohr DA, Klip A, Hill JA, Rothermel BA, Abel ED, Zorzano A, Lavandero S. PMID: 24009260; PMCID: PMC3868041.
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    132. Insulin suppresses ischemic preconditioning-mediated cardioprotection through Akt-dependent mechanisms. J Mol Cell Cardiol. 2013 Nov; 64:20-9. Fullmer TM, Pei S, Zhu Y, Sloan C, Manzanares R, Henrie B, Pires KM, Cox JE, Abel ED, Boudina S. PMID: 23994159; PMCID: PMC3835741.
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    133. Cardiac metabolism in heart failure: implications beyond ATP production. Circ Res. 2013 Aug 30; 113(6):709-24. Doenst T, Nguyen TD, Abel ED. PMID: 23989714; PMCID: PMC3896379.
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    134. IGF-1 receptor deficiency in thyrocytes impairs thyroid hormone secretion and completely inhibits TSH-stimulated goiter. FASEB J. 2013 Dec; 27(12):4899-908. Ock S, Ahn J, Lee SH, Kang H, Offermanns S, Ahn HY, Jo YS, Shong M, Cho BY, Jo D, Abel ED, Lee TJ, Park WJ, Lee IK, Kim J. PMID: 23982142.
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    135. Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy. Cardiovasc Res. 2013 Oct 01; 100(1):63-73. Kannan S, Muthusamy VR, Whitehead KJ, Wang L, Gomes AV, Litwin SE, Kensler TW, Abel ED, Hoidal JR, Rajasekaran NS. PMID: 23761402; PMCID: PMC3778956.
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    136. Regulation of fatty acid metabolism by mTOR in adult murine hearts occurs independently of changes in PGC-1α. Am J Physiol Heart Circ Physiol. 2013 Jul 01; 305(1):H41-51. Zhu Y, Soto J, Anderson B, Riehle C, Zhang YC, Wende AR, Jones D, McClain DA, Abel ED. PMID: 23624629; PMCID: PMC3727103.
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    137. A low-carbohydrate/high-fat diet reduces blood pressure in spontaneously hypertensive rats without deleterious changes in insulin resistance. Am J Physiol Heart Circ Physiol. 2013 Jun 15; 304(12):H1733-42. Bosse JD, Lin HY, Sloan C, Zhang QJ, Abel ED, Pereira TJ, Dolinsky VW, Symons JD, Jalili T. PMID: 23604708; PMCID: PMC3680768.
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    138. Lipotoxicity contributes to endothelial dysfunction: a focus on the contribution from ceramide. Rev Endocr Metab Disord. 2013 Mar; 14(1):59-68. Symons JD, Abel ED. PMID: 23292334; PMCID: PMC4180664.
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    139. Solid phase synthesis of mitochondrial triphenylphosphonium-vitamin E metabolite using a lysine linker for reversal of oxidative stress. PLoS One. 2013; 8(1):e53272. Mossalam M, Soto J, Lim CS, Abel ED. PMID: 23341934; PMCID: PMC3544826.
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    140. Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth. PLoS One. 2013; 8(1):e54221. Zhu Y, Pires KM, Whitehead KJ, Olsen CD, Wayment B, Zhang YC, Bugger H, Ilkun O, Litwin SE, Thomas G, Kozma SC, Abel ED. PMID: 23342106; PMCID: PMC3544830.
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    141. Cardiomyocyte specific deletion of Crif1 causes mitochondrial cardiomyopathy in mice. PLoS One. 2013; 8(1):e53577. Shin J, Lee SH, Kwon MC, Yang DK, Seo HR, Kim J, Kim YY, Im SK, Abel ED, Kim KT, Park WJ, Kong YY. PMID: 23308255; PMCID: PMC3537664.
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    142. Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload. J Biol Chem. 2013 Feb 08; 288(6):4252-64. Manso AM, Li R, Monkley SJ, Cruz NM, Ong S, Lao DH, Koshman YE, Gu Y, Peterson KL, Chen J, Abel ED, Samarel AM, Critchley DR, Ross RS. PMID: 23266827; PMCID: PMC3567677.
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    143. Mechanisms of lipotoxicity in the cardiovascular system. Curr Hypertens Rep. 2012 Dec; 14(6):517-31. Wende AR, Symons JD, Abel ED. PMID: 23054891; PMCID: PMC3491122.
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    144. Cardiac PI3K-Akt impairs insulin-stimulated glucose uptake independent of mTORC1 and GLUT4 translocation. Mol Endocrinol. 2013 Jan; 27(1):172-84. Zhu Y, Pereira RO, O'Neill BT, Riehle C, Ilkun O, Wende AR, Rawlings TA, Zhang YC, Zhang Q, Klip A, Shiojima I, Walsh K, Abel ED. PMID: 23204326; PMCID: PMC3545208.
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    145. Absence of glucose transporter 4 diminishes electrical activity of mouse hearts during hypoxia. Exp Physiol. 2013 Mar; 98(3):746-57. Sohn K, Wende AR, Abel ED, Moreno AP, Sachse FB, Punske BB. PMID: 23180812; PMCID: PMC6599691.
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    146. Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise training. PLoS One. 2012; 7(9):e45697. Gounder SS, Kannan S, Devadoss D, Miller CJ, Whitehead KJ, Whitehead KS, Odelberg SJ, Firpo MA, Paine R, Hoidal JR, Abel ED, Rajasekaran NS. PMID: 23029187; PMCID: PMC3454427.
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    147. Insulin resistance: metabolic mechanisms and consequences in the heart. Arterioscler Thromb Vasc Biol. 2012 Sep; 32(9):2068-76. Abel ED, O'Shea KM, Ramasamy R. PMID: 22895668; PMCID: PMC3646067.
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    148. PGC-1 proteins and heart failure. Trends Cardiovasc Med. 2012 May; 22(4):98-105. Riehle C, Abel ED. PMID: 22939990; PMCID: PMC3466400.
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    149. UCP3 regulates cardiac efficiency and mitochondrial coupling in high fat-fed mice but not in leptin-deficient mice. Diabetes. 2012 Dec; 61(12):3260-9. Boudina S, Han YH, Pei S, Tidwell TJ, Henrie B, Tuinei J, Olsen C, Sena S, Abel ED. PMID: 22912419; PMCID: PMC3501860.
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    150. HSPB2 is dispensable for the cardiac hypertrophic response but reduces mitochondrial energetics following pressure overload in mice. PLoS One. 2012; 7(8):e42118. Ishiwata T, Orosz A, Wang X, Mustafi SB, Pratt GW, Christians ES, Boudina S, Abel ED, Benjamin IJ. PMID: 22870288; PMCID: PMC3411653.
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    151. Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complex. Diabetes. 2012 Jul; 61(7):1848-59. Zhang QJ, Holland WL, Wilson L, Tanner JM, Kearns D, Cahoon JM, Pettey D, Losee J, Duncan B, Gale D, Kowalski CA, Deeter N, Nichols A, Deesing M, Arrant C, Ruan T, Boehme C, McCamey DR, Rou J, Ambal K, Narra KK, Summers SA, Abel ED, Symons JD. PMID: 22586587; PMCID: PMC3379648.
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    152. Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5. Circ Res. 2012 Jun 22; 111(1):50-5. Chen JX, Krane M, Deutsch MA, Wang L, Rav-Acha M, Gregoire S, Engels MC, Rajarajan K, Karra R, Abel ED, Wu JC, Milan D, Wu SM. PMID: 22581928; PMCID: PMC3390172.
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    153. Early mitochondrial adaptations in skeletal muscle to diet-induced obesity are strain dependent and determine oxidative stress and energy expenditure but not insulin sensitivity. Endocrinology. 2012 Jun; 153(6):2677-88. Boudina S, Sena S, Sloan C, Tebbi A, Han YH, O'Neill BT, Cooksey RC, Jones D, Holland WL, McClain DA, Abel ED. PMID: 22510273; PMCID: PMC3359615.
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    154. Modulation of the cardiovascular system by leptin. Biochimie. 2012 Oct; 94(10):2097-103. Abel ED, Sweeney G. PMID: 22490727.
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    155. Genetic loss of insulin receptors worsens cardiac efficiency in diabetes. J Mol Cell Cardiol. 2012 May; 52(5):1019-26. Bugger H, Riehle C, Jaishy B, Wende AR, Tuinei J, Chen D, Soto J, Pires KM, Boudina S, Theobald HA, Luptak I, Wayment B, Wang X, Litwin SE, Weimer BC, Abel ED. PMID: 22342406; PMCID: PMC3327790.
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    156. Endonuclease G: the link between mitochondria and cardiac hypertrophy? Circ Res. 2012 Feb 03; 110(3):378-80. Bugger H, Abel ED. PMID: 22302752.
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    158. Targeting myocardial substrate metabolism in heart failure: potential for new therapies. Eur J Heart Fail. 2012 Feb; 14(2):120-9. Ardehali H, Sabbah HN, Burke MA, Sarma S, Liu PP, Cleland JG, Maggioni A, Fonarow GC, Abel ED, Campia U, Gheorghiade M. PMID: 22253453; PMCID: PMC3260022.
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    159. NADPH oxidase-derived reactive oxygen species increases expression of monocyte chemotactic factor genes in cultured adipocytes. J Biol Chem. 2012 Mar 23; 287(13):10379-10393. Han CY, Umemoto T, Omer M, Den Hartigh LJ, Chiba T, LeBoeuf R, Buller CL, Sweet IR, Pennathur S, Abel ED, Chait A. PMID: 22287546; PMCID: PMC3322984.
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    160. Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy. Cardiovasc Res. 2012 Feb 01; 93(2):320-9. Troncoso R, Vicencio JM, Parra V, Nemchenko A, Kawashima Y, Del Campo A, Toro B, Battiprolu PK, Aranguiz P, Chiong M, Yakar S, Gillette TG, Hill JA, Abel ED, Leroith D, Lavandero S. PMID: 22135164; PMCID: PMC3286200.
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    161. Targeted inhibition of calpain reduces myocardial hypertrophy and fibrosis in mouse models of type 1 diabetes. Diabetes. 2011 Nov; 60(11):2985-94. Li Y, Ma J, Zhu H, Singh M, Hill D, Greer PA, Arnold JM, Abel ED, Peng T. PMID: 21911754; PMCID: PMC3198063.
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    162. Conditional deletion of insulin receptor in thyrocytes does not affect thyroid structure and function. Endocr J. 2011; 58(11):1013-9. Ock S, Lee SH, Ahn J, Lee TJ, Cho CH, Abel ED, Kimura S, Kim J. PMID: 21908931; PMCID: PMC3471790.
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    163. A new twist in the function of the cardiac lipid droplet. Nat Med. 2011 Sep 07; 17(9):1045-6. Abel ED. PMID: 21900917.
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    165. PGC-1β deficiency accelerates the transition to heart failure in pressure overload hypertrophy. Circ Res. 2011 Sep 16; 109(7):783-93. Riehle C, Wende AR, Zaha VG, Pires KM, Wayment B, Olsen C, Bugger H, Buchanan J, Wang X, Moreira AB, Doenst T, Medina-Gomez G, Litwin SE, Lelliott CJ, Vidal-Puig A, Abel ED. PMID: 21799152; PMCID: PMC3175248.
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    166. Expression of slow skeletal TnI in adult mouse hearts confers metabolic protection to ischemia. J Mol Cell Cardiol. 2011 Aug; 51(2):236-43. Pound KM, Arteaga GM, Fasano M, Wilder T, Fischer SK, Warren CM, Wende AR, Farjah M, Abel ED, Solaro RJ, Lewandowski ED. PMID: 21640727; PMCID: PMC3124599.
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    167. Central leptin signaling is required to normalize myocardial fatty acid oxidation rates in caloric-restricted ob/ob mice. Diabetes. 2011 May; 60(5):1424-34. Sloan C, Tuinei J, Nemetz K, Frandsen J, Soto J, Wride N, Sempokuya T, Alegria L, Bugger H, Abel ED. PMID: 21441440; PMCID: PMC3292315.
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    169. Obesity stresses cardiac mitochondria even when you are young. J Am Coll Cardiol. 2011 Feb 01; 57(5):586-9. Abel ED. PMID: 21272750.
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    170. Mitochondrial adaptations to physiological vs. pathological cardiac hypertrophy. Cardiovasc Res. 2011 May 01; 90(2):234-42. Abel ED, Doenst T. PMID: 21257612; PMCID: PMC3115280.
      View in: PubMed   Mentions: 148     Fields:    Translation:HumansAnimalsCells
    171. Fasting-induced reductions in cardiovascular and metabolic variables occur sooner in obese versus lean mice. Exp Biol Med (Maywood). 2010 Dec; 235(12):1489-97. Tanner JM, Kearns DT, Kim BJ, Sloan C, Jia Z, Yang T, Abel ED, Symons JD. PMID: 21127345; PMCID: PMC3367312.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    172. Knockout of insulin receptors in cardiomyocytes attenuates coronary arterial dysfunction induced by pressure overload. Am J Physiol Heart Circ Physiol. 2011 Jan; 300(1):H374-81. Symons JD, Hu P, Yang Y, Wang X, Zhang QJ, Wende AR, Sloan CL, Sena S, Abel ED, Litwin SE. PMID: 20971769; PMCID: PMC3023253.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    173. PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation. J Clin Invest. 2010 Oct; 120(10):3443-54. Son NH, Yu S, Tuinei J, Arai K, Hamai H, Homma S, Shulman GI, Abel ED, Goldberg IJ. PMID: 20852389; PMCID: PMC2947216.
      View in: PubMed   Mentions: 104     Fields:    Translation:AnimalsCells
    174. Free fatty acid oxidation in insulin resistance and obesity. Heart Metab. 2010 Sep 01; 48:5-10. Abel ED. PMID: 23646039; PMCID: PMC3643515.
      View in: PubMed   Mentions: 14  
    175. An APPL1-AMPK signaling axis mediates beneficial metabolic effects of adiponectin in the heart. Am J Physiol Endocrinol Metab. 2010 Nov; 299(5):E721-9. Fang X, Palanivel R, Cresser J, Schram K, Ganguly R, Thong FS, Tuinei J, Xu A, Abel ED, Sweeney G. PMID: 20739511; PMCID: PMC2980363.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    176. Mitochondria in the diabetic heart. Cardiovasc Res. 2010 Nov 01; 88(2):229-40. Bugger H, Abel ED. PMID: 20639213; PMCID: PMC2952534.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansAnimalsCells
    177. Preferential oxidation of triacylglyceride-derived fatty acids in heart is augmented by the nuclear receptor PPARalpha. Circ Res. 2010 Jul 23; 107(2):233-41. Banke NH, Wende AR, Leone TC, O'Donnell JM, Abel ED, Kelly DP, Lewandowski ED. PMID: 20522803; PMCID: PMC2921193.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    178. Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents. J Clin Invest. 2010 May; 120(5):1506-14. Shimizu I, Minamino T, Toko H, Okada S, Ikeda H, Yasuda N, Tateno K, Moriya J, Yokoyama M, Nojima A, Koh GY, Akazawa H, Shiojima I, Kahn CR, Abel ED, Komuro I. PMID: 20407209; PMCID: PMC2860916.
      View in: PubMed   Mentions: 122     Fields:    Translation:AnimalsCells
    179. Diabetic cardiomyopathy, causes and effects. Rev Endocr Metab Disord. 2010 Mar; 11(1):31-9. Boudina S, Abel ED. PMID: 20180026; PMCID: PMC2914514.
      View in: PubMed   Mentions: 370     Fields:    Translation:HumansCells
    180. Nuclear receptor SHP, a death receptor that targets mitochondria, induces apoptosis and inhibits tumor growth. Mol Cell Biol. 2010 Mar; 30(6):1341-56. Zhang Y, Soto J, Park K, Viswanath G, Kuwada S, Abel ED, Wang L. PMID: 20065042; PMCID: PMC2832505.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    181. Insulin signaling regulates mitochondrial function in pancreatic beta-cells. PLoS One. 2009 Nov 24; 4(11):e7983. Liu S, Okada T, Assmann A, Soto J, Liew CW, Bugger H, Shirihai OS, Abel ED, Kulkarni RN. PMID: 19956695; PMCID: PMC2776992.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    182. Mammalian target of rapamycin is a critical regulator of cardiac hypertrophy in spontaneously hypertensive rats. Hypertension. 2009 Dec; 54(6):1321-7. Soesanto W, Lin HY, Hu E, Lefler S, Litwin SE, Sena S, Abel ED, Symons JD, Jalili T. PMID: 19884565; PMCID: PMC2803027.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    183. Lipotoxicity in the heart. Biochim Biophys Acta. 2010 Mar; 1801(3):311-9. Wende AR, Abel ED. PMID: 19818871; PMCID: PMC2823976.
      View in: PubMed   Mentions: 161     Fields:    Translation:HumansAnimals
    184. Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy. J Mol Cell Cardiol. 2009 Nov; 47(5):664-75. Ikeda H, Shiojima I, Ozasa Y, Yoshida M, Holzenberger M, Kahn CR, Walsh K, Igarashi T, Abel ED, Komuro I. PMID: 19744489; PMCID: PMC4886750.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    185. Rodent models of diabetic cardiomyopathy. Dis Model Mech. 2009 Sep-Oct; 2(9-10):454-66. Bugger H, Abel ED. PMID: 19726805.
      View in: PubMed   Mentions: 145     Fields:    Translation:HumansAnimals
    186. Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice. Diabetes. 2009 Sep; 58(9):1986-97. Bugger H, Chen D, Riehle C, Soto J, Theobald HA, Hu XX, Ganesan B, Weimer BC, Abel ED. PMID: 19542201; PMCID: PMC2731527.
      View in: PubMed   Mentions: 97     Fields:    Translation:AnimalsCells
    187. Endothelial nitric oxide synthase phosphorylation in treadmill-running mice: role of vascular signalling kinases. J Physiol. 2009 Aug 01; 587(Pt 15):3911-20. Zhang QJ, McMillin SL, Tanner JM, Palionyte M, Abel ED, Symons JD. PMID: 19505983; PMCID: PMC2746618.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    188. Cerebellar neurons possess a vesicular compartment structurally and functionally similar to Glut4-storage vesicles from peripheral insulin-sensitive tissues. J Neurosci. 2009 Apr 22; 29(16):5193-201. Bakirtzi K, Belfort G, Lopez-Coviella I, Kuruppu D, Cao L, Abel ED, Brownell AL, Kandror KV. PMID: 19386915; PMCID: PMC2692175.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    189. Impaired insulin signaling accelerates cardiac mitochondrial dysfunction after myocardial infarction. J Mol Cell Cardiol. 2009 Jun; 46(6):910-8. Sena S, Hu P, Zhang D, Wang X, Wayment B, Olsen C, Avelar E, Abel ED, Litwin SE. PMID: 19249310; PMCID: PMC2683200.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    190. Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart. Circulation. 2009 Mar 10; 119(9):1272-83. Boudina S, Bugger H, Sena S, O'Neill BT, Zaha VG, Ilkun O, Wright JJ, Mazumder PK, Palfreyman E, Tidwell TJ, Theobald H, Khalimonchuk O, Wayment B, Sheng X, Rodnick KJ, Centini R, Chen D, Litwin SE, Weimer BE, Abel ED. PMID: 19237663; PMCID: PMC2739097.
      View in: PubMed   Mentions: 155     Fields:    Translation:AnimalsCells
    191. The role of mPer2 clock gene in glucocorticoid and feeding rhythms. Endocrinology. 2009 May; 150(5):2153-60. Yang S, Liu A, Weidenhammer A, Cooksey RC, McClain D, Kim MK, Aguilera G, Abel ED, Chung JH. PMID: 19179447; PMCID: PMC2671901.
      View in: PubMed   Mentions: 114     Fields:    Translation:Animals
    192. Mechanisms for increased myocardial fatty acid utilization following short-term high-fat feeding. Cardiovasc Res. 2009 May 01; 82(2):351-60. Wright JJ, Kim J, Buchanan J, Boudina S, Sena S, Bakirtzi K, Ilkun O, Theobald HA, Cooksey RC, Kandror KV, Abel ED. PMID: 19147655; PMCID: PMC2675931.
      View in: PubMed   Mentions: 97     Fields:    Translation:AnimalsCells
    193. Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy. Mol Endocrinol. 2008 Nov; 22(11):2531-43. Kim J, Wende AR, Sena S, Theobald HA, Soto J, Sloan C, Wayment BE, Litwin SE, Holzenberger M, LeRoith D, Abel ED. PMID: 18801929; PMCID: PMC2582541.
      View in: PubMed   Mentions: 102     Fields:    Translation:AnimalsCells
    194. Hearts lacking caveolin-1 develop hypertrophy with normal cardiac substrate metabolism. Cell Cycle. 2008 Aug 15; 7(16):2509-18. Augustus AS, Buchanan J, Gutman E, Rengo G, Pestell RG, Fortina P, Koch WJ, Bensadoun A, Abel ED, Lisanti MP. PMID: 18719368.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    195. Reversal of oxidative stress in endothelial cells by controlled release of adiponectin. J Control Release. 2008 Sep 24; 130(3):234-7. Mossalam M, Jeong JH, Abel ED, Kim SW, Kim YH. PMID: 18619503.
      View in: PubMed   Mentions: 6     Fields:    
    196. Substrate uptake and metabolism are preserved in hypertrophic caveolin-3 knockout hearts. Am J Physiol Heart Circ Physiol. 2008 Aug; 295(2):H657-66. Augustus AS, Buchanan J, Addya S, Rengo G, Pestell RG, Fortina P, Koch WJ, Bensadoun A, Abel ED, Lisanti MP. PMID: 18552160; PMCID: PMC2519224.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    197. Ceramide is a cardiotoxin in lipotoxic cardiomyopathy. J Lipid Res. 2008 Oct; 49(10):2101-12. Park TS, Hu Y, Noh HL, Drosatos K, Okajima K, Buchanan J, Tuinei J, Homma S, Jiang XC, Abel ED, Goldberg IJ. PMID: 18515784; PMCID: PMC2533410.
      View in: PubMed   Mentions: 225     Fields:    Translation:HumansAnimalsCells
    198. Captopril normalizes insulin signaling and insulin-regulated substrate metabolism in obese (ob/ob) mouse hearts. Endocrinology. 2008 Aug; 149(8):4043-50. Tabbi-Anneni I, Buchanan J, Cooksey RC, Abel ED. PMID: 18450963; PMCID: PMC2488224.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    199. Cardiac remodeling in obesity. Physiol Rev. 2008 Apr; 88(2):389-419. Abel ED, Litwin SE, Sweeney G. PMID: 18391168; PMCID: PMC2915933.
      View in: PubMed   Mentions: 329     Fields:    Translation:HumansAnimals
    200. Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis. Circulation. 2008 Mar 18; 117(11):1414-22. Yin Z, Jones GN, Towns WH, Zhang X, Abel ED, Binkley PF, Jarjoura D, Kirschner LS. PMID: 18316483.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    201. Iron-mediated inhibition of mitochondrial manganese uptake mediates mitochondrial dysfunction in a mouse model of hemochromatosis. Mol Med. 2008 Mar-Apr; 14(3-4):98-108. Jouihan HA, Cobine PA, Cooksey RC, Hoagland EA, Boudina S, Abel ED, Winge DR, McClain DA. PMID: 18317567; PMCID: PMC2258172.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    202. Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome. Clin Sci (Lond). 2008 Feb; 114(3):195-210. Bugger H, Abel ED. PMID: 18184113.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    203. Mitochondrial fusion and function in Charcot-Marie-Tooth type 2A patient fibroblasts with mitofusin 2 mutations. Exp Neurol. 2008 May; 211(1):115-27. Amiott EA, Lott P, Soto J, Kang PB, McCaffery JM, DiMauro S, Abel ED, Flanigan KM, Lawson VH, Shaw JM. PMID: 18316077; PMCID: PMC2409111.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    204. A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy. Cell Metab. 2007 Oct; 6(4):294-306. O'Neill BT, Kim J, Wende AR, Theobald HA, Tuinei J, Buchanan J, Guo A, Zaha VG, Davis DK, Schell JC, Boudina S, Wayment B, Litwin SE, Shioi T, Izumo S, Birnbaum MJ, Abel ED. PMID: 17908558; PMCID: PMC2084219.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    205. PAS kinase is required for normal cellular energy balance. Proc Natl Acad Sci U S A. 2007 Sep 25; 104(39):15466-71. Hao HX, Cardon CM, Swiatek W, Cooksey RC, Smith TL, Wilde J, Boudina S, Abel ED, McClain DA, Rutter J. PMID: 17878307; PMCID: PMC2000499.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    206. Cardiac hypertrophy caused by peroxisome proliferator- activated receptor-gamma agonist treatment occurs independently of changes in myocardial insulin signaling. Endocrinology. 2007 Dec; 148(12):6047-53. Sena S, Rasmussen IR, Wende AR, McQueen AP, Theobald HA, Wilde N, Pereira RO, Litwin SE, Berger JP, Abel ED. PMID: 17823261.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    207. Glucose for the aging heart? Circulation. 2007 Aug 21; 116(8):884-7. Abel ED. PMID: 17709649.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    208. Diabetic cardiomyopathy revisited. Circulation. 2007 Jun 26; 115(25):3213-23. Boudina S, Abel ED. PMID: 17592090.
      View in: PubMed   Mentions: 694     Fields:    Translation:HumansAnimalsCells
    209. Recipes for creating animal models of diabetic cardiovascular disease. Circ Res. 2007 May 25; 100(10):1415-27. Hsueh W, Abel ED, Breslow JL, Maeda N, Davis RC, Fisher EA, Dansky H, McClain DA, McIndoe R, Wassef MK, Rabadán-Diehl C, Goldberg IJ. PMID: 17525381.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansAnimals
    210. Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1. Cell Metab. 2007 Feb; 5(2):129-42. Sano M, Izumi Y, Helenius K, Asakura M, Rossi DJ, Xie M, Taffet G, Hu L, Pautler RG, Wilson CR, Boudina S, Abel ED, Taegtmeyer H, Scaglia F, Graham BH, Kralli A, Shimizu N, Tanaka H, Mäkelä TP, Schneider MD. PMID: 17276355.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    211. Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance. PLoS Biol. 2006 Nov; 4(11):e369. Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Strömstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A. PMID: 17090215; PMCID: PMC1634886.
      View in: PubMed   Mentions: 148     Fields:    Translation:AnimalsCells
    212. Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes. Physiology (Bethesda). 2006 Aug; 21:250-8. Boudina S, Abel ED. PMID: 16868314.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    213. Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase. J Card Fail. 2006 Jun; 12(5):392-8. Buerger A, Rozhitskaya O, Sherwood MC, Dorfman AL, Bisping E, Abel ED, Pu WT, Izumo S, Jay PY. PMID: 16762803.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    214. Loss of lipoprotein lipase-derived fatty acids leads to increased cardiac glucose metabolism and heart dysfunction. J Biol Chem. 2006 Mar 31; 281(13):8716-23. Augustus AS, Buchanan J, Park TS, Hirata K, Noh HL, Sun J, Homma S, D'armiento J, Abel ED, Goldberg IJ. PMID: 16410253.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    215. Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity. Circulation. 2005 Oct 25; 112(17):2686-95. Boudina S, Sena S, O'Neill BT, Tathireddy P, Young ME, Abel ED. PMID: 16246967.
      View in: PubMed   Mentions: 252     Fields:    Translation:AnimalsCells
    216. Contractile dysfunction in hypertrophied hearts with deficient insulin receptor signaling: possible role of reduced capillary density. J Mol Cell Cardiol. 2005 Dec; 39(6):882-92. McQueen AP, Zhang D, Hu P, Swenson L, Yang Y, Zaha VG, Hoffman JL, Yun UJ, Chakrabarti G, Wang Z, Albertine KH, Abel ED, Litwin SE. PMID: 16216265.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    217. Akt1 in the cardiovascular system: friend or foe? J Clin Invest. 2005 Aug; 115(8):2059-64. O'Neill BT, Abel ED. PMID: 16075047; PMCID: PMC1180557.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    218. The intrinsic circadian clock within the cardiomyocyte. Am J Physiol Heart Circ Physiol. 2005 Oct; 289(4):H1530-41. Durgan DJ, Hotze MA, Tomlin TM, Egbejimi O, Graveleau C, Abel ED, Shaw CA, Bray MS, Hardin PE, Young ME. PMID: 15937094.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    219. Myocardial insulin resistance and cardiac complications of diabetes. Curr Drug Targets Immune Endocr Metabol Disord. 2005 Jun; 5(2):219-26. Abel ED. PMID: 16089356.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimals
    220. Insulin signaling in heart muscle: lessons from genetically engineered mouse models. Curr Hypertens Rep. 2004 Dec; 6(6):416-23. Abel ED. PMID: 15527684.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    221. Glucose transport in the heart. Front Biosci. 2004 Jan 01; 9:201-15. Abel ED. PMID: 14766360.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimals
    222. An unliganded thyroid hormone receptor causes severe neurological dysfunction. Proc Natl Acad Sci U S A. 2001 Mar 27; 98(7):3998-4003. Hashimoto K, Curty FH, Borges PP, Lee CE, Abel ED, Elmquist JK, Cohen RN, Wondisford FE. PMID: 11274423; PMCID: PMC31168.
      View in: PubMed   Mentions: 75     Fields:    Translation:Animals
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