-
Diabetes mellitus-Progress and opportunities in the evolving epidemic. Cell. 2024 Jul 25; 187(15):3789-3820.
Abel ED, Gloyn AL, Evans-Molina C, Joseph JJ, Misra S, Pajvani UB, Simcox J, Susztak K, Drucker DJ. PMID: 39059357; PMCID: PMC11299851.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCellsPHPublic Health
-
Diabetes Suppresses Glucose Uptake and Glycolysis in Macrophages. Circ Res. 2022 03 04; 130(5):779-781.
Matsuura Y, Shimizu-Albergine M, Barnhart S, Kramer F, Hsu CC, Kothari V, Tang J, Gharib SA, Kanter JE, Abel ED, Tian R, Shao B, Bornfeldt KE. PMID: 35170337; PMCID: PMC8897241.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansCells
-
Perinatal versus adult loss of ULK1 and ULK2 distinctly influences cardiac autophagy and function. Autophagy. 2022 09; 18(9):2161-2177.
Harris MP, Zhang QJ, Cochran CT, Ponce J, Alexander S, Kronemberger A, Fuqua JD, Zhang Y, Fattal R, Harper T, Murry ML, Grueter CE, Abel ED, Lira VA. PMID: 35104184; PMCID: PMC9466614.
View in:
PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
-
Protocols for Generating Surfaces and Measuring 3D Organelle Morphology Using Amira. Cells. 2021 12 27; 11(1).
Garza-Lopez E, Vue Z, Katti P, Neikirk K, Biete M, Lam J, Beasley HK, Marshall AG, Rodman TA, Christensen TA, Salisbury JL, Vang L, Mungai M, AshShareef S, Murray SA, Shao J, Streeter J, Glancy B, Pereira RO, Abel ED, Hinton A. PMID: 35011629; PMCID: PMC8750564.
View in:
PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
-
Calpain-2 specifically cleaves Junctophilin-2 at the same site as Calpain-1 but with less efficacy. Biochem J. 2021 10 15; 478(19):3539-3553.
Wang J, Ciampa G, Zheng D, Shi Q, Chen B, Abel ED, Peng T, Hall DD, Song LS. PMID: 34524407; PMCID: PMC8589432.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
-
Skeletal muscle type-specific mitochondrial adaptation to high-fat diet relies on differential autophagy modulation. FASEB J. 2021 10; 35(10):e21933.
Morales PE, Monsalves-Álvarez M, Tadinada SM, Harris MP, Ramírez-Sagredo A, Ortiz-Quintero J, Troncoso MF, De Gregorio N, Calle X, Pereira RO, Lira VA, Espinosa A, Abel ED, Lavandero S. PMID: 34555201.
View in:
PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
-
Insulin and IGF-1 receptors regulate complex I-dependent mitochondrial bioenergetics and supercomplexes via FoxOs in muscle. J Clin Invest. 2021 09 15; 131(18).
Bhardwaj G, Penniman CM, Jena J, Suarez Beltran PA, Foster C, Poro K, Junck TL, Hinton AO, Souvenir R, Fuqua JD, Morales PE, Bravo-Sagua R, Sivitz WI, Lira VA, Abel ED, O'Neill BT. PMID: 34343133; PMCID: PMC8439595.
View in:
PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
-
Functional resilience of C57BL/6J mouse heart to dietary fat overload. Am J Physiol Heart Circ Physiol. 2021 11 01; 321(5):H850-H864.
Tadinada SM, Weatherford ET, Collins GV, Bhardwaj G, Cochran J, Kutschke W, Zimmerman K, Bosko A, O'Neill BT, Weiss RM, Abel ED. PMID: 34477461; PMCID: PMC8616610.
View in:
PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
-
A Universal Approach to Analyzing Transmission Electron Microscopy with ImageJ. Cells. 2021 08 24; 10(9).
Lam J, Katti P, Biete M, Mungai M, AshShareef S, Neikirk K, Garza Lopez E, Vue Z, Christensen TA, Beasley HK, Rodman TA, Murray SA, Salisbury JL, Glancy B, Shao J, Pereira RO, Abel ED, Hinton A. PMID: 34571826; PMCID: PMC8465115.
View in:
PubMed Mentions:
86 Fields:
Translation:
AnimalsCells
-
Insulin signaling in the heart. Am J Physiol Endocrinol Metab. 2021 07 01; 321(1):E130-E145.
Abel ED. PMID: 34056923; PMCID: PMC8321827.
View in:
PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
-
Cardiac Energy Metabolism in Heart Failure. Circ Res. 2021 05 14; 128(10):1487-1513.
Lopaschuk GD, Karwi QG, Tian R, Wende AR, Abel ED. PMID: 33983836; PMCID: PMC8136750.
View in:
PubMed Mentions:
348 Fields:
Translation:
HumansCells
-
OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21. Elife. 2021 05 04; 10.
Pereira RO, Marti A, Olvera AC, Tadinada SM, Bjorkman SH, Weatherford ET, Morgan DA, Westphal M, Patel PH, Kirby AK, Hewezi R, Bùi Trân W, García-Peña LM, Souvenir RA, Mittal M, Adams CM, Rahmouni K, Potthoff MJ, Abel ED. PMID: 33944779; PMCID: PMC8128440.
View in:
PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
-
Therapeutic potential of targeting oxidative stress in diabetic cardiomyopathy. Free Radic Biol Med. 2021 06; 169:317-342.
Byrne NJ, Rajasekaran NS, Abel ED, Bugger H. PMID: 33910093; PMCID: PMC8285002.
View in:
PubMed Mentions:
56 Fields:
Translation:
Humans
-
Reply to Petersen et al.: An alternative hypothesis for why exposure to static magnetic and electric fields treats type 2 diabetes. Am J Physiol Endocrinol Metab. 2021 05 01; 320(5):E1004-E1005.
Carter CS, Huang SC, Searby CC, Cassaidy B, Miller MJ, Grzesik WJ, Piorczynski TB, Pak TK, Walsh SA, Acevedo M, Zhang Q, Mapuskar KA, Milne GL, Hinton AO, Guo DF, Weiss R, Bradberry K, Taylor EB, Rauckhorst AJ, Dick DW, Akurathi V, Falls-Hubert KC, Wagner BA, Carter WA, Wang K, Norris AW, Rahmouni K, Buettner GR, Hansen JM, Spitz DR, Abel ED, Sheffield VC. PMID: 33843283; PMCID: PMC8238129.
View in:
PubMed Mentions: Fields:
Translation:
Humans
-
Counterpoint: An alternative hypothesis for why exposure to static magnetic and electric fields treats type 2 diabetes. Am J Physiol Endocrinol Metab. 2021 05 01; 320(5):E1001-E1002.
Carter CS, Huang SC, Searby CC, Cassaidy B, Miller MJ, Grzesik WJ, Piorczynski TB, Pak TK, Walsh SA, Acevedo M, Zhang Q, Mapuskar KA, Milne GL, Hinton AO, Guo DF, Weiss R, Bradberry K, Taylor EB, Rauckhorst AJ, Dick DW, Akurathi V, Falls-Hubert KC, Wagner BA, Carter WA, Wang K, Norris AW, Rahmouni K, Buettner GR, Hansen JM, Spitz DR, Abel ED, Sheffield VC. PMID: 33843282; PMCID: PMC8238130.
View in:
PubMed Mentions:
1 Fields:
Translation:
Humans
-
GLUT1 Expression in Tumor-Associated Neutrophils Promotes Lung Cancer Growth and Resistance to Radiotherapy. Cancer Res. 2021 05 01; 81(9):2345-2357.
Ancey PB, Contat C, Boivin G, Sabatino S, Pascual J, Zangger N, Perentes JY, Peters S, Abel ED, Kirsch DG, Rathmell JC, Vozenin MC, Meylan E. PMID: 33753374; PMCID: PMC8137580.
View in:
PubMed Mentions:
58 Fields:
Translation:
HumansAnimalsCells
-
mTOR Mediated Metabolic Rewiring and Ischemic Preconditioning, its Complicated. Circ Res. 2021 03 05; 128(5):652-654.
Abel ED. PMID: 34219792; PMCID: PMC8244748.
View in:
PubMed Mentions:
1 Fields:
-
FoxO1 is required for physiological cardiac hypertrophy induced by exercise but not by constitutively active PI3K. Am J Physiol Heart Circ Physiol. 2021 04 01; 320(4):H1470-H1485.
Weeks KL, Tham YK, Yildiz SG, Alexander Y, Donner DG, Kiriazis H, Harmawan CA, Hsu A, Bernardo BC, Matsumoto A, DePinho RA, Abel ED, Woodcock EA, McMullen JR. PMID: 33577435.
View in:
PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
-
An early endothelial cell-specific requirement for Glut1 is revealed in Glut1 deficiency syndrome model mice. JCI Insight. 2021 02 08; 6(3).
Tang M, Park SH, Petri S, Yu H, Rueda CB, Abel ED, Kim CY, Hillman EM, Li F, Lee Y, Ding L, Jagadish S, Frankel WN, De Vivo DC, Monani UR. PMID: 33351789; PMCID: PMC7934852.
View in:
PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
-
It takes a village: lessons from collaborative science. J Clin Invest. 2021 01 19; 131(2).
Abel ED. PMID: 33463544; PMCID: PMC7810490.
View in:
PubMed Mentions:
1 Fields:
Translation:
Humans
-
Publisher Correction: Mitochondrial pyruvate carriers are required for myocardial stress adaptation. Nat Metab. 2020 Dec; 2(12):1498.
Zhang Y, Taufalele PV, Cochran JD, Robillard-Frayne I, Marx JM, Soto J, Rauckhorst AJ, Tayyari F, Pewa AD, Gray LR, Teesch LM, Puchalska P, Funari TR, McGlauflin R, Zimmerman K, Kutschke WJ, Cassier T, Hitchcock S, Lin K, Kato KM, Stueve JL, Haff L, Weiss RM, Cox JE, Rutter J, Taylor EB, Crawford PA, Lewandowski ED, Des Rosiers C, Abel ED. PMID: 33208925.
View in:
PubMed Mentions:
1 Fields:
-
Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes. Cell Metab. 2020 Dec 01; 32(6):1076.
Carter CS, Huang SC, Searby CC, Cassaidy B, Miller MJ, Grzesik WJ, Piorczynski TB, Pak TK, Walsh SA, Acevedo M, Zhang Q, Mapuskar KA, Milne GL, Hinton AO, Guo DF, Weiss R, Bradberry K, Taylor EB, Rauckhorst AJ, Dick DW, Akurathi V, Falls-Hubert KC, Wagner BA, Carter WA, Wang K, Norris AW, Rahmouni K, Buettner GR, Hansen JM, Spitz DR, Abel ED, Sheffield VC. PMID: 33264599.
View in:
PubMed Mentions:
5 Fields:
-
Mitochondrial pyruvate carriers are required for myocardial stress adaptation. Nat Metab. 2020 11; 2(11):1248-1264.
Zhang Y, Taufalele PV, Cochran JD, Robillard-Frayne I, Marx JM, Soto J, Rauckhorst AJ, Tayyari F, Pewa AD, Gray LR, Teesch LM, Puchalska P, Funari TR, McGlauflin R, Zimmerman K, Kutschke WJ, Cassier T, Hitchcock S, Lin K, Kato KM, Stueve JL, Haff L, Weiss RM, Cox JE, Rutter J, Taylor EB, Crawford PA, Lewandowski ED, Des Rosiers C, Abel ED. PMID: 33106689; PMCID: PMC8015649.
View in:
PubMed Mentions:
70 Fields:
Translation:
AnimalsCells
-
Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes. Cell Metab. 2020 10 06; 32(4):561-574.e7.
Carter CS, Huang SC, Searby CC, Cassaidy B, Miller MJ, Grzesik WJ, Piorczynski TB, Pak TK, Walsh SA, Acevedo M, Zhang Q, Mapuskar KA, Milne GL, Hinton AO, Guo DF, Weiss R, Bradberry K, Taylor EB, Rauckhorst AJ, Dick DW, Akurathi V, Falls-Hubert KC, Wagner BA, Carter WA, Wang K, Norris AW, Rahmouni K, Buettner GR, Hansen JM, Spitz DR, Abel ED, Sheffield VC. PMID: 33027675; PMCID: PMC7819711.
View in:
PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
-
SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism. Elife. 2020 09 15; 9.
Kumar A, Xie L, Ta CM, Hinton AO, Gunasekar SK, Minerath RA, Shen K, Maurer JM, Grueter CE, Abel ED, Meyer G, Sah R. PMID: 32930093; PMCID: PMC7541086.
View in:
PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
-
Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization. J Am Heart Assoc. 2020 08 04; 9(15):e013039.
Brahma MK, Ha CM, Pepin ME, Mia S, Sun Z, Chatham JC, Habegger KM, Abel ED, Paterson AJ, Young ME, Wende AR. PMID: 32750298; PMCID: PMC7792234.
View in:
PubMed Mentions:
36 Fields:
Translation:
AnimalsCells
-
Both aerobic glycolysis and mitochondrial respiration are required for osteoclast differentiation. FASEB J. 2020 08; 34(8):11058-11067.
Li B, Lee WC, Song C, Ye L, Abel ED, Long F. PMID: 32627870.
View in:
PubMed Mentions:
41 Fields:
Translation:
AnimalsCells
-
Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth. Elife. 2020 06 23; 9.
Contat C, Ancey PB, Zangger N, Sabatino S, Pascual J, Escrig S, Jensen L, Goepfert C, Lanz B, Lepore M, Gruetter R, Rossier A, Berezowska S, Neppl C, Zlobec I, Clerc-Rosset S, Knott GW, Rathmell JC, Abel ED, Meibom A, Meylan E. PMID: 32571479; PMCID: PMC7311173.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
-
Reductive Stress Causes Pathological Cardiac Remodeling and Diastolic Dysfunction. Antioxid Redox Signal. 2020 06; 32(18):1293-1312.
Shanmugam G, Wang D, Gounder SS, Fernandes J, Litovsky SH, Whitehead K, Radhakrishnan RK, Franklin S, Hoidal JR, Kensler TW, Dell'Italia L, Darley-Usmar V, Abel ED, Jones DP, Ping P, Rajasekaran NS. PMID: 32064894; PMCID: PMC7247052.
View in:
PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
-
Basic Mechanisms of Diabetic Heart Disease. Circ Res. 2020 05 22; 126(11):1501-1525.
Ritchie RH, Abel ED. PMID: 32437308; PMCID: PMC7251974.
View in:
PubMed Mentions:
214 Fields:
Translation:
HumansAnimals
-
Role of the GLUT1 Glucose Transporter in Postnatal CNS Angiogenesis and Blood-Brain Barrier Integrity. Circ Res. 2020 07 31; 127(4):466-482.
Veys K, Fan Z, Ghobrial M, Bouché A, García-Caballero M, Vriens K, Conchinha NV, Seuwen A, Schlegel F, Gorski T, Crabbé M, Gilardoni P, Ardicoglu R, Schaffenrath J, Casteels C, De Smet G, Smolders I, Van Laere K, Abel ED, Fendt SM, Schroeter A, Kalucka J, Cantelmo AR, Wälchli T, Keller A, Carmeliet P, De Bock K. PMID: 32404031; PMCID: PMC7386868.
View in:
PubMed Mentions:
73 Fields:
Translation:
HumansAnimalsCells
-
Maintaining Myocardial Glucose Utilization in Diabetic Cardiomyopathy Accelerates Mitochondrial Dysfunction. Diabetes. 2020 10; 69(10):2094-2111.
Wende AR, Schell JC, Ha CM, Pepin ME, Khalimonchuk O, Schwertz H, Pereira RO, Brahma MK, Tuinei J, Contreras-Ferrat A, Wang L, Andrizzi CA, Olsen CD, Bradley WE, Dell'Italia LJ, Dillmann WH, Litwin SE, Abel ED. PMID: 32366681; PMCID: PMC7506832.
View in:
PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
-
The Role of Nonglycolytic Glucose Metabolism in Myocardial Recovery Upon Mechanical Unloading and Circulatory Support in Chronic Heart Failure. Circulation. 2020 07 21; 142(3):259-274.
Badolia R, Ramadurai DKA, Abel ED, Ferrin P, Taleb I, Shankar TS, Krokidi AT, Navankasattusas S, McKellar SH, Yin M, Kfoury AG, Wever-Pinzon O, Fang JC, Selzman CH, Chaudhuri D, Rutter J, Drakos SG. PMID: 32351122; PMCID: PMC7380956.
View in:
PubMed Mentions:
35 Fields:
Translation:
HumansCells
-
Stress-Induced Cyclin C Translocation Regulates Cardiac Mitochondrial Dynamics. J Am Heart Assoc. 2020 04 07; 9(7):e014366.
Ponce JM, Coen G, Spitler KM, Dragisic N, Martins I, Hinton A, Mungai M, Tadinada SM, Zhang H, Oudit GY, Song LS, Li N, Sicinski P, Strack S, Abel ED, Mitchell C, Hall DD, Grueter CE. PMID: 32248761; PMCID: PMC7428645.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
-
Insulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodeling. JCI Insight. 2020 03 26; 5(6).
Riehle C, Weatherford ET, Wende AR, Jaishy BP, Seei AW, McCarty NS, Rech M, Shi Q, Reddy GR, Kutschke WJ, Oliveira K, Pires KM, Anderson JC, Diakos NA, Weiss RM, White MF, Drakos SG, Xiang YK, Abel ED. PMID: 32213702; PMCID: PMC7213803.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansAnimals
-
Autophagy Reprograms Alveolar Progenitor Cell Metabolism in Response to Lung Injury. Stem Cell Reports. 2020 03 10; 14(3):420-432.
Li X, Wu J, Sun X, Wu Q, Li Y, Li K, Zhang Q, Li Y, Abel ED, Chen H. PMID: 32059792; PMCID: PMC7066233.
View in:
PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
-
Airway epithelial regeneration requires autophagy and glucose metabolism. Cell Death Dis. 2019 11 20; 10(12):875.
Li K, Li M, Li W, Yu H, Sun X, Zhang Q, Li Y, Li X, Li Y, Abel ED, Wu Q, Chen H. PMID: 31748541; PMCID: PMC6868131.
View in:
PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
-
p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas. Cell Rep. 2019 08 13; 28(7):1860-1878.e9.
Hsieh MH, Choe JH, Gadhvi J, Kim YJ, Arguez MA, Palmer M, Gerold H, Nowak C, Do H, Mazambani S, Knighton JK, Cha M, Goodwin J, Kang MK, Jeong JY, Lee SY, Faubert B, Xuan Z, Abel ED, Scafoglio C, Shackelford DB, Minna JD, Singh PK, Shulaev V, Bleris L, Hoyt K, Kim J, Inoue M, DeBerardinis RJ, Kim TH, Kim JW. PMID: 31412252; PMCID: PMC7048935.
View in:
PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
-
Loss of MCU prevents mitochondrial fusion in G1-S phase and blocks cell cycle progression and proliferation. Sci Signal. 2019 04 30; 12(579).
Koval OM, Nguyen EK, Santhana V, Fidler TP, Sebag SC, Rasmussen TP, Mittauer DJ, Strack S, Goswami PC, Abel ED, Grumbach IM. PMID: 31040260; PMCID: PMC6768401.
View in:
PubMed Mentions:
37 Fields:
Translation:
AnimalsCells
-
Comparison of the Effects of High-Fat Diet on Energy Flux in Mice Using Two Multiplexed Metabolic Phenotyping Systems. Obesity (Silver Spring). 2019 05; 27(5):793-802.
Soto JE, Burnett CML, Ten Eyck P, Abel ED, Grobe JL. PMID: 30938081; PMCID: PMC6478533.
View in:
PubMed Mentions:
19 Fields:
Translation:
Animals
-
Increased glycolysis mediates Wnt7b-induced bone formation. FASEB J. 2019 07; 33(7):7810-7821.
Chen H, Ji X, Lee WC, Shi Y, Li B, Abel ED, Jiang D, Huang W, Long F. PMID: 30913395; PMCID: PMC6593878.
View in:
PubMed Mentions:
35 Fields:
Translation:
AnimalsCells
-
Glucose Metabolism Is Required for Platelet Hyperactivation in a Murine Model of Type 1 Diabetes. Diabetes. 2019 05; 68(5):932-938.
Fidler TP, Marti A, Gerth K, Middleton EA, Campbell RA, Rondina MT, Weyrich AS, Abel ED. PMID: 30765335; PMCID: PMC6477909.
View in:
PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
-
Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1. J Immunol. 2019 02 15; 202(4):1265-1286.
Freemerman AJ, Zhao L, Pingili AK, Teng B, Cozzo AJ, Fuller AM, Johnson AR, Milner JJ, Lim MF, Galanko JA, Beck MA, Bear JE, Rotty JD, Bezavada L, Smallwood HS, Puchowicz MA, Liu J, Locasale JW, Lee DP, Bennett BJ, Abel ED, Rathmell JC, Makowski L. PMID: 30659108; PMCID: PMC6360258.
View in:
PubMed Mentions:
67 Fields:
Translation:
AnimalsCells
-
Heart Failure in Type 2 Diabetes Mellitus. Circ Res. 2019 01 04; 124(1):121-141.
Kenny HC, Abel ED. PMID: 30605420; PMCID: PMC6447311.
View in:
PubMed Mentions:
248 Fields:
Translation:
HumansAnimalsCells
-
Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure. Circ Res. 2019 01 04; 124(1):161-169.
Berry JL, Zhu W, Tang YL, Krishnamurthy P, Ge Y, Cooke JP, Chen Y, Garry DJ, Yang HT, Rajasekaran NS, Koch WJ, Li S, Domae K, Qin G, Cheng K, Kamp TJ, Ye L, Hu S, Ogle BM, Rogers JM, Abel ED, Davis ME, Prabhu SD, Liao R, Pu WT, Wang Y, Ping P, Bursac N, Vunjak-Novakovic G, Wu JC, Bolli R, Menasché P, Zhang J. PMID: 30605412; PMCID: PMC6350935.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansAnimals
-
Modulating GLUT1 expression in retinal pigment epithelium decreases glucose levels in the retina: impact on photoreceptors and Müller glial cells. Am J Physiol Cell Physiol. 2019 01 01; 316(1):C121-C133.
Swarup A, Samuels IS, Bell BA, Han JYS, Du J, Massenzio E, Abel ED, Boesze-Battaglia K, Peachey NS, Philp NJ. PMID: 30462537; PMCID: PMC6383144.
View in:
PubMed Mentions:
60 Fields:
Translation:
AnimalsCells
-
Glucose metabolism induced by Bmp signaling is essential for murine skeletal development. Nat Commun. 2018 11 16; 9(1):4831.
Lee SY, Abel ED, Long F. PMID: 30446646; PMCID: PMC6240091.
View in:
PubMed Mentions:
61 Fields:
Translation:
AnimalsCells
-
Thyrocyte-specific deletion of insulin and IGF-1 receptors induces papillary thyroid carcinoma-like lesions through EGFR pathway activation. Int J Cancer. 2018 11 15; 143(10):2458-2469.
Ock S, Ahn J, Lee SH, Kim HM, Kang H, Kim YK, Kook H, Park WJ, Kim S, Kimura S, Jung CK, Shong M, Holzenberger M, Abel ED, Lee TJ, Cho BY, Kim HS, Kim J. PMID: 30070361; PMCID: PMC6698377.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
-
Effective Metabolic Approaches for the Energy Starved Failing Heart: Bioenergetic Resiliency via Redundancy or Something Else? Circ Res. 2018 07 20; 123(3):329-331.
Zhang J, Abel ED. PMID: 30026379; PMCID: PMC6055933.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
-
Prorenin independently causes hypertension and renal and cardiac fibrosis in cyp1a1-prorenin transgenic rats. Clin Sci (Lond). 2018 06 29; 132(12):1345-1363.
Zhou G, Wu J, Gu C, Wang B, Abel ED, Cheung AK, Huang Y. PMID: 29848510; PMCID: PMC6024026.
View in:
PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
-
Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis. Nat Med. 2018 05; 24(5):617-627.
Zhang Z, Zi Z, Lee EE, Zhao J, Contreras DC, South AP, Abel ED, Chong BF, Vandergriff T, Hosler GA, Scherer PE, Mettlen M, Rathmell JC, DeBerardinis RJ, Wang RC. PMID: 29662201; PMCID: PMC6095711.
View in:
PubMed Mentions:
65 Fields:
Translation:
HumansAnimalsCells
-
Deletion of GLUT1 in mouse lens epithelium leads to cataract formation. Exp Eye Res. 2018 07; 172:45-53.
Swarup A, Bell BA, Du J, Han JYS, Soto J, Abel ED, Bravo-Nuevo A, FitzGerald PG, Peachey NS, Philp NJ. PMID: 29604281; PMCID: PMC6716165.
View in:
PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
-
Connexin43 and zonula occludens-1 are targets of Akt in cardiomyocytes that correlate with cardiac contractile dysfunction in Akt deficient hearts. Biochim Biophys Acta Mol Basis Dis. 2018 Apr; 1864(4 Pt A):1183-1191.
Ock S, Lee WS, Kim HM, Park KS, Kim YK, Kook H, Park WJ, Lee TJ, Abel ED, Kim J. PMID: 29378301; PMCID: PMC6342503.
View in:
PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
-
MITOCHONDRIAL DYNAMICS AND METABOLIC REGULATION IN CARDIAC AND SKELETAL MUSCLE. Trans Am Clin Climatol Assoc. 2018; 129:266-278.
Abel ED. PMID: 30166722; PMCID: PMC6116613.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
-
Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation. JCI Insight. 2017 12 21; 2(24).
Nabeebaccus AA, Zoccarato A, Hafstad AD, Santos CX, Aasum E, Brewer AC, Zhang M, Beretta M, Yin X, West JA, Schröder K, Griffin JL, Eykyn TR, Abel ED, Mayr M, Shah AM. PMID: 29263294; PMCID: PMC5752273.
View in:
PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
-
Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function. Cell Rep. 2017 11 07; 21(6):1705.
Fidler TP, Campbell RA, Funari T, Dunne N, Balderas Angeles E, Middleton EA, Chaudhuri D, Weyrich AS, Abel ED. PMID: 29117572; PMCID: PMC5700809.
View in:
PubMed Mentions:
9 Fields:
-
Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induce Post-Translational Modifications of AKAP121, DRP1, and OPA1 That Promote Mitochondrial Fission. Circ Res. 2018 01 05; 122(1):58-73.
Tsushima K, Bugger H, Wende AR, Soto J, Jenson GA, Tor AR, McGlauflin R, Kenny HC, Zhang Y, Souvenir R, Hu XX, Sloan CL, Pereira RO, Lira VA, Spitzer KW, Sharp TL, Shoghi KI, Sparagna GC, Rog-Zielinska EA, Kohl P, Khalimonchuk O, Schaffer JE, Abel ED. PMID: 29092894; PMCID: PMC5756120.
View in:
PubMed Mentions:
152 Fields:
Translation:
AnimalsCells
-
Activation of IGF-1 receptors and Akt signaling by systemic hyperinsulinemia contributes to cardiac hypertrophy but does not regulate cardiac autophagy in obese diabetic mice. J Mol Cell Cardiol. 2017 12; 113:39-50.
Pires KM, Buffolo M, Schaaf C, David Symons J, Cox J, Abel ED, Selzman CH, Boudina S. PMID: 28987875; PMCID: PMC5689477.
View in:
PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
-
Insulin-dependent metabolic and inotropic responses in the heart are modulated by hydrogen peroxide from NADPH-oxidase isoforms NOX2 and NOX4. Free Radic Biol Med. 2017 12; 113:16-25.
Steinhorn B, Sartoretto JL, Sorrentino A, Romero N, Kalwa H, Abel ED, Michel T. PMID: 28917508; PMCID: PMC5699944.
View in:
PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
-
Corrigendum: Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling. Nat Commun. 2017 08 30; 8:16155.
Rines AK, Chang HC, Wu R, Sato T, Khechaduri A, Kouzu H, Shapiro J, Shang M, Burke MA, Abdelwahid E, Jiang X, Chen C, Rawlings TA, Lopaschuk GD, Schumacker PT, Abel ED, Ardehali H. PMID: 28853433; PMCID: PMC5582347.
View in:
PubMed Mentions:
2 Fields:
-
Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function. Cell Rep. 2017 08 29; 20(9):2277.
Fidler TP, Campbell RA, Funari T, Dunne N, Balderas Angeles E, Middleton EA, Chaudhuri D, Weyrch AS, Abel ED. PMID: 28854375.
View in:
PubMed Mentions:
2 Fields:
-
Glucose transporter 4-deficient hearts develop maladaptive hypertrophy in response to physiological or pathological stresses. Am J Physiol Heart Circ Physiol. 2017 Dec 01; 313(6):H1098-H1108.
Wende AR, Kim J, Holland WL, Wayment BE, O'Neill BT, Tuinei J, Brahma MK, Pepin ME, McCrory MA, Luptak I, Halade GV, Litwin SE, Abel ED. PMID: 28822962; PMCID: PMC5814656.
View in:
PubMed Mentions:
32 Fields:
Translation:
Animals
-
Superoxide Dismutase 2 is dispensable for platelet function. Thromb Haemost. 2017 10 05; 117(10):1859-1867.
Fidler TP, Rowley JW, Araujo C, Boudreau LH, Marti A, Souvenir R, Dale K, Boilard E, Weyrich AS, Abel ED. PMID: 28771279; PMCID: PMC5894334.
View in:
PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
-
DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging. Cell Metab. 2017 08 01; 26(2):447.
Park SJ, Gavrilova O, Brown AL, Soto JE, Bremner S, Kim J, Xu X, Yang S, Um JH, Koch LG, Britton SL, Lieber RL, Philp A, Baar K, Kohama SG, Abel ED, Kim MK, Chung JH. PMID: 28768182.
View in:
PubMed Mentions:
12 Fields:
-
Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function. Cell Rep. 2017 07 25; 20(4):881-894.
Fidler TP, Campbell RA, Funari T, Dunne N, Balderas Angeles E, Middleton EA, Chaudhuri D, Weyrich AS, Abel ED. PMID: 28746873; PMCID: PMC5600478.
View in:
PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
-
Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heart. J Mol Cell Cardiol. 2017 09; 110:80-95.
McGinnis GR, Tang Y, Brewer RA, Brahma MK, Stanley HL, Shanmugam G, Rajasekaran NS, Rowe GC, Frank SJ, Wende AR, Abel ED, Taegtmeyer H, Litovsky S, Darley-Usmar V, Zhang J, Chatham JC, Young ME. PMID: 28736261; PMCID: PMC5586500.
View in:
PubMed Mentions:
45 Fields:
Translation:
AnimalsCells
-
Glucose Transporter 3 Potentiates Degranulation and Is Required for Platelet Activation. Arterioscler Thromb Vasc Biol. 2017 09; 37(9):1628-1639.
Fidler TP, Middleton EA, Rowley JW, Boudreau LH, Campbell RA, Souvenir R, Funari T, Tessandier N, Boilard E, Weyrich AS, Abel ED. PMID: 28663252; PMCID: PMC5570649.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
-
Erratum: SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis. Nat Cell Biol. 2017 Jun 29; 19(7):873.
Zhang Y, Xie L, Gunasekar SK, Tong D, Mishra A, Gibson WJ, Wang C, Fidler T, Marthaler B, Klingelhutz A, Abel ED, Samuel I, Smith JK, Cao L, Sah R. PMID: 28659636.
View in:
PubMed Mentions:
1 Fields:
-
OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance. EMBO J. 2017 07 14; 36(14):2126-2145.
Pereira RO, Tadinada SM, Zasadny FM, Oliveira KJ, Pires KMP, Olvera A, Jeffers J, Souvenir R, Mcglauflin R, Seei A, Funari T, Sesaki H, Potthoff MJ, Adams CM, Anderson EJ, Abel ED. PMID: 28607005; PMCID: PMC5510002.
View in:
PubMed Mentions:
110 Fields:
Translation:
Animals
-
Erratum: SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis. Nat Cell Biol. 2017 May 31; 19(6):740.
Zhang Y, Xie L, Gunasekar SK, Tong D, Mishra A, Gibson WJ, Wang C, Fidler T, Marthaler B, Klingelhutz A, Abel ED, Samuel I, Smith JK, Cao L, Sah R. PMID: 28561048.
View in:
PubMed Mentions: Fields:
-
DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging. Cell Metab. 2017 May 02; 25(5):1135-1146.e7.
Park SJ, Gavrilova O, Brown AL, Soto JE, Bremner S, Kim J, Xu X, Yang S, Um JH, Koch LG, Britton SL, Lieber RL, Philp A, Baar K, Kohama SG, Abel ED, Kim MK, Chung JH. PMID: 28467930; PMCID: PMC5485859.
View in:
PubMed Mentions:
52 Fields:
Translation:
AnimalsCells
-
SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis. Nat Cell Biol. 2017 05; 19(5):504-517.
Zhang Y, Xie L, Gunasekar SK, Tong D, Mishra A, Gibson WJ, Wang C, Fidler T, Marthaler B, Klingelhutz A, Abel ED, Samuel I, Smith JK, Cao L, Sah R. PMID: 28436964; PMCID: PMC5415409.
View in:
PubMed Mentions:
79 Fields:
Translation:
HumansAnimalsCells
-
Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling. Nat Commun. 2017 01 24; 8:14095.
Rines AK, Chang HC, Wu R, Sato T, Khechaduri A, Kouzu H, Shapiro J, Shang M, Burke MA, Abdelwahid E, Jiang X, Chen C, Rawlings TA, Lopaschuk GD, Schumacker PT, Abel ED, Ardehali H. PMID: 28117339; PMCID: PMC5286102.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
-
The glucose transporter GLUT1 is required for ErbB2-induced mammary tumorigenesis. Breast Cancer Res. 2016 12 20; 18(1):131.
Wellberg EA, Johnson S, Finlay-Schultz J, Lewis AS, Terrell KL, Sartorius CA, Abel ED, Muller WJ, Anderson SM. PMID: 27998284; PMCID: PMC5168867.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
-
Inhibiting Insulin-Mediated β2-Adrenergic Receptor Activation Prevents Diabetes-Associated Cardiac Dysfunction. Circulation. 2017 Jan 03; 135(1):73-88.
Wang Q, Liu Y, Fu Q, Xu B, Zhang Y, Kim S, Tan R, Barbagallo F, West T, Anderson E, Wei W, Abel ED, Xiang YK. PMID: 27815373; PMCID: PMC5302024.
View in:
PubMed Mentions:
63 Fields:
Translation:
HumansAnimalsCells
-
Evidence of Glycolysis Up-Regulation and Pyruvate Mitochondrial Oxidation Mismatch During Mechanical Unloading of the Failing Human Heart: Implications for Cardiac Reloading and Conditioning. JACC Basic Transl Sci. 2016 Oct; 1(6):432-444.
Diakos NA, Navankasattusas S, Abel ED, Rutter J, McCreath L, Ferrin P, McKellar SH, Miller DV, Park SY, Richardson RS, Deberardinis R, Cox JE, Kfoury AG, Selzman CH, Stehlik J, Fang JC, Li DY, Drakos SG. PMID: 28497127; PMCID: PMC5422992.
View in:
PubMed Mentions:
76
-
Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat Commun. 2016 10 10; 7:12948.
Trammell SA, Schmidt MS, Weidemann BJ, Redpath P, Jaksch F, Dellinger RW, Li Z, Abel ED, Migaud ME, Brenner C. PMID: 27721479; PMCID: PMC5062546.
View in:
PubMed Mentions:
321 Fields:
Translation:
HumansAnimalsCells
-
Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis. J Clin Invest. 2016 09 01; 126(9):3433-46.
O'Neill BT, Lee KY, Klaus K, Softic S, Krumpoch MT, Fentz J, Stanford KI, Robinson MM, Cai W, Kleinridders A, Pereira RO, Hirshman MF, Abel ED, Accili D, Goodyear LJ, Nair KS, Kahn CR. PMID: 27525440; PMCID: PMC5004956.
View in:
PubMed Mentions:
87 Fields:
Translation:
AnimalsCells
-
Lipids, lysosomes, and autophagy. J Lipid Res. 2016 09; 57(9):1619-35.
Jaishy B, Abel ED. PMID: 27330054; PMCID: PMC5003162.
View in:
PubMed Mentions:
103 Fields:
Translation:
HumansCells
-
AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival. Cell Metab. 2016 Apr 12; 23(4):649-62.
Kishton RJ, Barnes CE, Nichols AG, Cohen S, Gerriets VA, Siska PJ, Macintyre AN, Goraksha-Hicks P, de Cubas AA, Liu T, Warmoes MO, Abel ED, Yeoh AE, Gershon TR, Rathmell WK, Richards KL, Locasale JW, Rathmell JC. PMID: 27076078; PMCID: PMC4832577.
View in:
PubMed Mentions:
123 Fields:
Translation:
HumansAnimalsCells
-
Insulin Signaling and Heart Failure. Circ Res. 2016 Apr 01; 118(7):1151-69.
Riehle C, Abel ED. PMID: 27034277; PMCID: PMC4833475.
View in:
PubMed Mentions:
188 Fields:
Translation:
HumansAnimalsCells
-
Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association. Circ Res. 2016 May 13; 118(10):1659-701.
Taegtmeyer H, Young ME, Lopaschuk GD, Abel ED, Brunengraber H, Darley-Usmar V, Des Rosiers C, Gerszten R, Glatz JF, Griffin JL, Gropler RJ, Holzhuetter HG, Kizer JR, Lewandowski ED, Malloy CR, Neubauer S, Peterson LR, Portman MA, Recchia FA, Van Eyk JE, Wang TJ, American Heart Association Council on Basic Cardiovascular Sciences. PMID: 27012580; PMCID: PMC5130157.
View in:
PubMed Mentions:
132 Fields:
Translation:
HumansAnimals
-
Exercise training improves vascular mitochondrial function. Am J Physiol Heart Circ Physiol. 2016 Apr 01; 310(7):H821-9.
Park SY, Rossman MJ, Gifford JR, Bharath LP, Bauersachs J, Richardson RS, Abel ED, Symons JD, Riehle C. PMID: 26825520; PMCID: PMC4867356.
View in:
PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
-
Phosphoinositide dependent protein kinase 1 is required for exercise-induced cardiac hypertrophy but not the associated mitochondrial adaptations. J Mol Cell Cardiol. 2015 Dec; 89(Pt B):297-305.
Noh J, Wende AR, Olsen CD, Kim B, Bevins J, Zhu Y, Zhang QJ, Riehle C, Abel ED. PMID: 26476238; PMCID: PMC4689617.
View in:
PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
-
Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy. Diabetes. 2016 Jan; 65(1):255-68.
Ni R, Zheng D, Xiong S, Hill DJ, Sun T, Gardiner RB, Fan GC, Lu Y, Abel ED, Greer PA, Peng T. PMID: 26470784; PMCID: PMC4686953.
View in:
PubMed Mentions:
81 Fields:
Translation:
AnimalsCells
-
Deletion of IGF-1 Receptors in Cardiomyocytes Attenuates Cardiac Aging in Male Mice. Endocrinology. 2016 Jan; 157(1):336-45.
Ock S, Lee WS, Ahn J, Kim HM, Kang H, Kim HS, Jo D, Abel ED, Lee TJ, Kim J. PMID: 26469138; PMCID: PMC4701888.
View in:
PubMed Mentions:
46 Fields:
Translation:
AnimalsCells
-
Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses. Cell. 2015 Sep 10; 162(6):1217-28.
Ho PC, Bihuniak JD, Macintyre AN, Staron M, Liu X, Amezquita R, Tsui YC, Cui G, Micevic G, Perales JC, Kleinstein SH, Abel ED, Insogna KL, Feske S, Locasale JW, Bosenberg MW, Rathmell JC, Kaech SM. PMID: 26321681; PMCID: PMC4567953.
View in:
PubMed Mentions:
715 Fields:
Translation:
AnimalsCells
-
Ceramide-Initiated Protein Phosphatase 2A Activation Contributes to Arterial Dysfunction In Vivo. Diabetes. 2015 Nov; 64(11):3914-26.
Bharath LP, Ruan T, Li Y, Ravindran A, Wan X, Nhan JK, Walker ML, Deeter L, Goodrich R, Johnson E, Munday D, Mueller R, Kunz D, Jones D, Reese V, Summers SA, Babu PV, Holland WL, Zhang QJ, Abel ED, Symons JD. PMID: 26253611; PMCID: PMC4613970.
View in:
PubMed Mentions:
63 Fields:
Translation:
AnimalsCells
-
Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis. J Clin Invest. 2015 Sep; 125(9):3461-76.
Liao X, Zhang R, Lu Y, Prosdocimo DA, Sangwung P, Zhang L, Zhou G, Anand P, Lai L, Leone TC, Fujioka H, Ye F, Rosca MG, Hoppel CL, Schulze PC, Abel ED, Stamler JS, Kelly DP, Jain MK. PMID: 26241060; PMCID: PMC4588311.
View in:
PubMed Mentions:
64 Fields:
Translation:
HumansAnimalsCells
-
Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):9129-34.
Rasmussen TP, Wu Y, Joiner ML, Koval OM, Wilson NR, Luczak ED, Wang Q, Chen B, Gao Z, Zhu Z, Wagner BA, Soto J, McCormick ML, Kutschke W, Weiss RM, Yu L, Boudreau RL, Abel ED, Zhan F, Spitz DR, Buettner GR, Song LS, Zingman LV, Anderson ME. PMID: 26153425; PMCID: PMC4517214.
View in:
PubMed Mentions:
99 Fields:
Translation:
AnimalsCells
-
Antioxidant treatment normalizes mitochondrial energetics and myocardial insulin sensitivity independently of changes in systemic metabolic homeostasis in a mouse model of the metabolic syndrome. J Mol Cell Cardiol. 2015 Aug; 85:104-16.
Ilkun O, Wilde N, Tuinei J, Pires KM, Zhu Y, Bugger H, Soto J, Wayment B, Olsen C, Litwin SE, Abel ED. PMID: 26004364; PMCID: PMC4530070.
View in:
PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
-
Myocardial mitochondrial dysfunction in mice lacking adiponectin receptor 1. Basic Res Cardiol. 2015; 110(4):37.
Koentges C, König A, Pfeil K, Hölscher ME, Schnick T, Wende AR, Schrepper A, Cimolai MC, Kersting S, Hoffmann MM, Asal J, Osterholt M, Odening KE, Doenst T, Hein L, Abel ED, Bode C, Bugger H. PMID: 25982881.
View in:
PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
-
GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration. Nat Neurosci. 2015 Apr; 18(4):521-530.
Winkler EA, Nishida Y, Sagare AP, Rege SV, Bell RD, Perlmutter D, Sengillo JD, Hillman S, Kong P, Nelson AR, Sullivan JS, Zhao Z, Meiselman HJ, Wendy RB, Soto J, Abel ED, Makshanoff J, Zuniga E, De Vivo DC, Zlokovic BV. PMID: 25730668; PMCID: PMC4734893.
View in:
PubMed Mentions:
308 Fields:
Translation:
Animals
-
Enhanced cardiac Akt/protein kinase B signaling contributes to pathological cardiac hypertrophy in part by impairing mitochondrial function via transcriptional repression of mitochondrion-targeted nuclear genes. Mol Cell Biol. 2015 Mar; 35(5):831-46.
Wende AR, O'Neill BT, Bugger H, Riehle C, Tuinei J, Buchanan J, Tsushima K, Wang L, Caro P, Guo A, Sloan C, Kim BJ, Wang X, Pereira RO, McCrory MA, Nye BG, Benavides GA, Darley-Usmar VM, Shioi T, Weimer BC, Abel ED. PMID: 25535334; PMCID: PMC4323486.
View in:
PubMed Mentions:
49 Fields:
Translation:
AnimalsCells
-
Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity. J Lipid Res. 2015 Mar; 56(3):546-561.
Jaishy B, Zhang Q, Chung HS, Riehle C, Soto J, Jenkins S, Abel P, Cowart LA, Van Eyk JE, Abel ED. PMID: 25529920; PMCID: PMC4340303.
View in:
PubMed Mentions:
64 Fields:
Translation:
AnimalsCells
-
Insulin regulation of myocardial autophagy. Circ J. 2014; 78(11):2569-76.
Riehle C, Abel ED. PMID: 25327953; PMCID: PMC5609463.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
-
Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis. Cell Death Dis. 2014 Oct 16; 5:e1470.
Liu T, Kishton RJ, Macintyre AN, Gerriets VA, Xiang H, Liu X, Abel ED, Rizzieri D, Locasale JW, Rathmell JC. PMID: 25321477; PMCID: PMC4237255.
View in:
PubMed Mentions:
45 Fields:
Translation:
HumansCells
-
Insulin receptor substrates are essential for the bioenergetic and hypertrophic response of the heart to exercise training. Mol Cell Biol. 2014 Sep 15; 34(18):3450-60.
Riehle C, Wende AR, Zhu Y, Oliveira KJ, Pereira RO, Jaishy BP, Bevins J, Valdez S, Noh J, Kim BJ, Moreira AB, Weatherford ET, Manivel R, Rawlings TA, Rech M, White MF, Abel ED. PMID: 25002528; PMCID: PMC4135616.
View in:
PubMed Mentions:
62 Fields:
Translation:
AnimalsCells
-
The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. Cell Metab. 2014 Jul 01; 20(1):61-72.
Macintyre AN, Gerriets VA, Nichols AG, Michalek RD, Rudolph MC, Deoliveira D, Anderson SM, Abel ED, Chen BJ, Hale LP, Rathmell JC. PMID: 24930970; PMCID: PMC4079750.
View in:
PubMed Mentions:
575 Fields:
Translation:
HumansAnimalsCells
-
Maintaining PGC-1α expression following pressure overload-induced cardiac hypertrophy preserves angiogenesis but not contractile or mitochondrial function. FASEB J. 2014 Aug; 28(8):3691-702.
Pereira RO, Wende AR, Crum A, Hunter D, Olsen CD, Rawlings T, Riehle C, Ward WF, Abel ED. PMID: 24776744; PMCID: PMC4101649.
View in:
PubMed Mentions:
37 Fields:
Translation:
HumansAnimalsCells
-
Time to look back and to look forward. Diabetes. 2014 Apr; 63(4):1169-70.
Nair KS, Abel ED, Adler SG, Dyck PJ, Gardner TW, Haskins KM, Hotamisligil G, Jensen MD, Krook A, Mandarino LJ, Mitchell BD, Pessin JE, Sowers JR, Sussel L, Wareham N, Vella A. PMID: 24651796.
View in:
PubMed Mentions: Fields:
Translation:
Humans
-
Insulin inhibits cardiac contractility by inducing a Gi-biased β2-adrenergic signaling in hearts. Diabetes. 2014 Aug; 63(8):2676-89.
Fu Q, Xu B, Liu Y, Parikh D, Li J, Li Y, Zhang Y, Riehle C, Zhu Y, Rawlings T, Shi Q, Clark RB, Chen X, Abel ED, Xiang YK. PMID: 24677713; PMCID: PMC4113065.
View in:
PubMed Mentions:
46 Fields:
Translation:
AnimalsCells
-
Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells. J Immunol. 2014 Apr 15; 192(8):3626-36.
Caro-Maldonado A, Wang R, Nichols AG, Kuraoka M, Milasta S, Sun LD, Gavin AL, Abel ED, Kelsoe G, Green DR, Rathmell JC. PMID: 24616478; PMCID: PMC3984038.
View in:
PubMed Mentions:
268 Fields:
Translation:
HumansAnimalsCells
-
GLUT1 deficiency in cardiomyocytes does not accelerate the transition from compensated hypertrophy to heart failure. J Mol Cell Cardiol. 2014 Jul; 72:95-103.
Pereira RO, Wende AR, Olsen C, Soto J, Rawlings T, Zhu Y, Riehle C, Abel ED. PMID: 24583251; PMCID: PMC4037364.
View in:
PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
-
Molecular mechanisms of diabetic cardiomyopathy. Diabetologia. 2014 Apr; 57(4):660-71.
Bugger H, Abel ED. PMID: 24477973; PMCID: PMC3969857.
View in:
PubMed Mentions:
406 Fields:
Translation:
HumansAnimals
-
The absence of insulin signaling in the heart induces changes in potassium channel expression and ventricular repolarization. Am J Physiol Heart Circ Physiol. 2014 Mar 01; 306(5):H747-54.
Lopez-Izquierdo A, Pereira RO, Wende AR, Punske BB, Abel ED, Tristani-Firouzi M. PMID: 24375641; PMCID: PMC3949065.
View in:
PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
-
Insulin receptor substrate signaling suppresses neonatal autophagy in the heart. J Clin Invest. 2013 Dec; 123(12):5319-33.
Riehle C, Wende AR, Sena S, Pires KM, Pereira RO, Zhu Y, Bugger H, Frank D, Bevins J, Chen D, Perry CN, Dong XC, Valdez S, Rech M, Sheng X, Weimer BC, Gottlieb RA, White MF, Abel ED. PMID: 24177427; PMCID: PMC3859408.
View in:
PubMed Mentions:
68 Fields:
Translation:
AnimalsCells
-
Podocyte-specific GLUT4-deficient mice have fewer and larger podocytes and are protected from diabetic nephropathy. Diabetes. 2014 Feb; 63(2):701-14.
Guzman J, Jauregui AN, Merscher-Gomez S, Maiguel D, Muresan C, Mitrofanova A, Diez-Sampedro A, Szust J, Yoo TH, Villarreal R, Pedigo C, Molano RD, Johnson K, Kahn B, Hartleben B, Huber TB, Saha J, Burke GW, Abel ED, Brosius FC, Fornoni A. PMID: 24101677; PMCID: PMC3900538.
View in:
PubMed Mentions:
28 Fields:
Translation:
AnimalsCells
-
Inducible overexpression of GLUT1 prevents mitochondrial dysfunction and attenuates structural remodeling in pressure overload but does not prevent left ventricular dysfunction. J Am Heart Assoc. 2013 Sep 19; 2(5):e000301.
Pereira RO, Wende AR, Olsen C, Soto J, Rawlings T, Zhu Y, Anderson SM, Abel ED. PMID: 24052497; PMCID: PMC3835233.
View in:
PubMed Mentions:
57 Fields:
Translation:
AnimalsCells
-
Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the Akt-mTOR-NFκB-Opa-1 signaling pathway. Diabetes. 2014 Jan; 63(1):75-88.
Parra V, Verdejo HE, Iglewski M, Del Campo A, Troncoso R, Jones D, Zhu Y, Kuzmicic J, Pennanen C, Lopez-Crisosto C, Jaña F, Ferreira J, Noguera E, Chiong M, Bernlohr DA, Klip A, Hill JA, Rothermel BA, Abel ED, Zorzano A, Lavandero S. PMID: 24009260; PMCID: PMC3868041.
View in:
PubMed Mentions:
104 Fields:
Translation:
AnimalsCells
-
Insulin suppresses ischemic preconditioning-mediated cardioprotection through Akt-dependent mechanisms. J Mol Cell Cardiol. 2013 Nov; 64:20-9.
Fullmer TM, Pei S, Zhu Y, Sloan C, Manzanares R, Henrie B, Pires KM, Cox JE, Abel ED, Boudina S. PMID: 23994159; PMCID: PMC3835741.
View in:
PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
-
Cardiac metabolism in heart failure: implications beyond ATP production. Circ Res. 2013 Aug 30; 113(6):709-24.
Doenst T, Nguyen TD, Abel ED. PMID: 23989714; PMCID: PMC3896379.
View in:
PubMed Mentions:
512 Fields:
Translation:
HumansAnimalsCells
-
IGF-1 receptor deficiency in thyrocytes impairs thyroid hormone secretion and completely inhibits TSH-stimulated goiter. FASEB J. 2013 Dec; 27(12):4899-908.
Ock S, Ahn J, Lee SH, Kang H, Offermanns S, Ahn HY, Jo YS, Shong M, Cho BY, Jo D, Abel ED, Lee TJ, Park WJ, Lee IK, Kim J. PMID: 23982142.
View in:
PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
-
Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy. Cardiovasc Res. 2013 Oct 01; 100(1):63-73.
Kannan S, Muthusamy VR, Whitehead KJ, Wang L, Gomes AV, Litwin SE, Kensler TW, Abel ED, Hoidal JR, Rajasekaran NS. PMID: 23761402; PMCID: PMC3778956.
View in:
PubMed Mentions:
51 Fields:
Translation:
AnimalsCells
-
Regulation of fatty acid metabolism by mTOR in adult murine hearts occurs independently of changes in PGC-1α. Am J Physiol Heart Circ Physiol. 2013 Jul 01; 305(1):H41-51.
Zhu Y, Soto J, Anderson B, Riehle C, Zhang YC, Wende AR, Jones D, McClain DA, Abel ED. PMID: 23624629; PMCID: PMC3727103.
View in:
PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
-
A low-carbohydrate/high-fat diet reduces blood pressure in spontaneously hypertensive rats without deleterious changes in insulin resistance. Am J Physiol Heart Circ Physiol. 2013 Jun 15; 304(12):H1733-42.
Bosse JD, Lin HY, Sloan C, Zhang QJ, Abel ED, Pereira TJ, Dolinsky VW, Symons JD, Jalili T. PMID: 23604708; PMCID: PMC3680768.
View in:
PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
-
Lipotoxicity contributes to endothelial dysfunction: a focus on the contribution from ceramide. Rev Endocr Metab Disord. 2013 Mar; 14(1):59-68.
Symons JD, Abel ED. PMID: 23292334; PMCID: PMC4180664.
View in:
PubMed Mentions:
58 Fields:
Translation:
HumansAnimals
-
Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth. PLoS One. 2013; 8(1):e54221.
Zhu Y, Pires KM, Whitehead KJ, Olsen CD, Wayment B, Zhang YC, Bugger H, Ilkun O, Litwin SE, Thomas G, Kozma SC, Abel ED. PMID: 23342106; PMCID: PMC3544830.
View in:
PubMed Mentions:
51 Fields:
Translation:
Animals
-
Solid phase synthesis of mitochondrial triphenylphosphonium-vitamin E metabolite using a lysine linker for reversal of oxidative stress. PLoS One. 2013; 8(1):e53272.
Mossalam M, Soto J, Lim CS, Abel ED. PMID: 23341934; PMCID: PMC3544826.
View in:
PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
-
Cardiomyocyte specific deletion of Crif1 causes mitochondrial cardiomyopathy in mice. PLoS One. 2013; 8(1):e53577.
Shin J, Lee SH, Kwon MC, Yang DK, Seo HR, Kim J, Kim YY, Im SK, Abel ED, Kim KT, Park WJ, Kong YY. PMID: 23308255; PMCID: PMC3537664.
View in:
PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
-
Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload. J Biol Chem. 2013 Feb 08; 288(6):4252-64.
Manso AM, Li R, Monkley SJ, Cruz NM, Ong S, Lao DH, Koshman YE, Gu Y, Peterson KL, Chen J, Abel ED, Samarel AM, Critchley DR, Ross RS. PMID: 23266827; PMCID: PMC3567677.
View in:
PubMed Mentions:
52 Fields:
Translation:
HumansAnimalsCells
-
Mechanisms of lipotoxicity in the cardiovascular system. Curr Hypertens Rep. 2012 Dec; 14(6):517-31.
Wende AR, Symons JD, Abel ED. PMID: 23054891; PMCID: PMC3491122.
View in:
PubMed Mentions:
58 Fields:
Translation:
HumansCells
-
Cardiac PI3K-Akt impairs insulin-stimulated glucose uptake independent of mTORC1 and GLUT4 translocation. Mol Endocrinol. 2013 Jan; 27(1):172-84.
Zhu Y, Pereira RO, O'Neill BT, Riehle C, Ilkun O, Wende AR, Rawlings TA, Zhang YC, Zhang Q, Klip A, Shiojima I, Walsh K, Abel ED. PMID: 23204326; PMCID: PMC3545208.
View in:
PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
-
Absence of glucose transporter 4 diminishes electrical activity of mouse hearts during hypoxia. Exp Physiol. 2013 Mar; 98(3):746-57.
Sohn K, Wende AR, Abel ED, Moreno AP, Sachse FB, Punske BB. PMID: 23180812; PMCID: PMC6599691.
View in:
PubMed Mentions:
5 Fields:
Translation:
Animals
-
Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise training. PLoS One. 2012; 7(9):e45697.
Gounder SS, Kannan S, Devadoss D, Miller CJ, Whitehead KJ, Whitehead KS, Odelberg SJ, Firpo MA, Paine R, Hoidal JR, Abel ED, Rajasekaran NS. PMID: 23029187; PMCID: PMC3454427.
View in:
PubMed Mentions:
81 Fields:
Translation:
AnimalsCells
-
Insulin resistance: metabolic mechanisms and consequences in the heart. Arterioscler Thromb Vasc Biol. 2012 Sep; 32(9):2068-76.
Abel ED, O'Shea KM, Ramasamy R. PMID: 22895668; PMCID: PMC3646067.
View in:
PubMed Mentions:
97 Fields:
Translation:
HumansAnimalsCells
-
PGC-1 proteins and heart failure. Trends Cardiovasc Med. 2012 May; 22(4):98-105.
Riehle C, Abel ED. PMID: 22939990; PMCID: PMC3466400.
View in:
PubMed Mentions:
56 Fields:
Translation:
HumansAnimals
-
UCP3 regulates cardiac efficiency and mitochondrial coupling in high fat-fed mice but not in leptin-deficient mice. Diabetes. 2012 Dec; 61(12):3260-9.
Boudina S, Han YH, Pei S, Tidwell TJ, Henrie B, Tuinei J, Olsen C, Sena S, Abel ED. PMID: 22912419; PMCID: PMC3501860.
View in:
PubMed Mentions:
37 Fields:
Translation:
AnimalsCells
-
HSPB2 is dispensable for the cardiac hypertrophic response but reduces mitochondrial energetics following pressure overload in mice. PLoS One. 2012; 7(8):e42118.
Ishiwata T, Orosz A, Wang X, Mustafi SB, Pratt GW, Christians ES, Boudina S, Abel ED, Benjamin IJ. PMID: 22870288; PMCID: PMC3411653.
View in:
PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
-
Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complex. Diabetes. 2012 Jul; 61(7):1848-59.
Zhang QJ, Holland WL, Wilson L, Tanner JM, Kearns D, Cahoon JM, Pettey D, Losee J, Duncan B, Gale D, Kowalski CA, Deeter N, Nichols A, Deesing M, Arrant C, Ruan T, Boehme C, McCamey DR, Rou J, Ambal K, Narra KK, Summers SA, Abel ED, Symons JD. PMID: 22586587; PMCID: PMC3379648.
View in:
PubMed Mentions:
129 Fields:
Translation:
AnimalsCells
-
Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5. Circ Res. 2012 Jun 22; 111(1):50-5.
Chen JX, Krane M, Deutsch MA, Wang L, Rav-Acha M, Gregoire S, Engels MC, Rajarajan K, Karra R, Abel ED, Wu JC, Milan D, Wu SM. PMID: 22581928; PMCID: PMC3390172.
View in:
PubMed Mentions:
126 Fields:
Translation:
HumansAnimalsCells
-
Early mitochondrial adaptations in skeletal muscle to diet-induced obesity are strain dependent and determine oxidative stress and energy expenditure but not insulin sensitivity. Endocrinology. 2012 Jun; 153(6):2677-88.
Boudina S, Sena S, Sloan C, Tebbi A, Han YH, O'Neill BT, Cooksey RC, Jones D, Holland WL, McClain DA, Abel ED. PMID: 22510273; PMCID: PMC3359615.
View in:
PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
-
Modulation of the cardiovascular system by leptin. Biochimie. 2012 Oct; 94(10):2097-103.
Abel ED, Sweeney G. PMID: 22490727.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimals
-
Genetic loss of insulin receptors worsens cardiac efficiency in diabetes. J Mol Cell Cardiol. 2012 May; 52(5):1019-26.
Bugger H, Riehle C, Jaishy B, Wende AR, Tuinei J, Chen D, Soto J, Pires KM, Boudina S, Theobald HA, Luptak I, Wayment B, Wang X, Litwin SE, Weimer BC, Abel ED. PMID: 22342406; PMCID: PMC3327790.
View in:
PubMed Mentions:
40 Fields:
Translation:
AnimalsCells
-
Endonuclease G: the link between mitochondria and cardiac hypertrophy? Circ Res. 2012 Feb 03; 110(3):378-80.
Bugger H, Abel ED. PMID: 22302752.
View in:
PubMed Mentions:
1 Fields:
-
Receptor activator of nuclear factor-κB ligand is a novel inducer of myocardial inflammation. Cardiovasc Res. 2012 Apr 01; 94(1):105-14.
Ock S, Ahn J, Lee SH, Park H, Son JW, Oh JG, Yang DK, Lee WS, Kim HS, Rho J, Oh GT, Abel ED, Park WJ, Min JK, Kim J. PMID: 22298642.
View in:
PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
-
Targeting myocardial substrate metabolism in heart failure: potential for new therapies. Eur J Heart Fail. 2012 Feb; 14(2):120-9.
Ardehali H, Sabbah HN, Burke MA, Sarma S, Liu PP, Cleland JG, Maggioni A, Fonarow GC, Abel ED, Campia U, Gheorghiade M. PMID: 22253453; PMCID: PMC3260022.
View in:
PubMed Mentions:
83 Fields:
Translation:
HumansAnimalsCells
-
NADPH oxidase-derived reactive oxygen species increases expression of monocyte chemotactic factor genes in cultured adipocytes. J Biol Chem. 2012 Mar 23; 287(13):10379-10393.
Han CY, Umemoto T, Omer M, Den Hartigh LJ, Chiba T, LeBoeuf R, Buller CL, Sweet IR, Pennathur S, Abel ED, Chait A. PMID: 22287546; PMCID: PMC3322984.
View in:
PubMed Mentions:
81 Fields:
Translation:
AnimalsCells
-
Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy. Cardiovasc Res. 2012 Feb 01; 93(2):320-9.
Troncoso R, Vicencio JM, Parra V, Nemchenko A, Kawashima Y, Del Campo A, Toro B, Battiprolu PK, Aranguiz P, Chiong M, Yakar S, Gillette TG, Hill JA, Abel ED, Leroith D, Lavandero S. PMID: 22135164; PMCID: PMC3286200.
View in:
PubMed Mentions:
62 Fields:
Translation:
AnimalsCells
-
Targeted inhibition of calpain reduces myocardial hypertrophy and fibrosis in mouse models of type 1 diabetes. Diabetes. 2011 Nov; 60(11):2985-94.
Li Y, Ma J, Zhu H, Singh M, Hill D, Greer PA, Arnold JM, Abel ED, Peng T. PMID: 21911754; PMCID: PMC3198063.
View in:
PubMed Mentions:
69 Fields:
Translation:
AnimalsCells
-
Conditional deletion of insulin receptor in thyrocytes does not affect thyroid structure and function. Endocr J. 2011; 58(11):1013-9.
Ock S, Lee SH, Ahn J, Lee TJ, Cho CH, Abel ED, Kimura S, Kim J. PMID: 21908931; PMCID: PMC3471790.
View in:
PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
-
A new twist in the function of the cardiac lipid droplet. Nat Med. 2011 Sep 07; 17(9):1045-6.
Abel ED. PMID: 21900917.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
-
The maximal downstroke of epicardial potentials as an index of electrical activity in mouse hearts. IEEE Trans Biomed Eng. 2011 Nov; 58(11):3175-83.
Sohn K, Sachse FB, Moreno AP, Ershler PR, Wende AR, Abel ED, Punske BB. PMID: 21859611.
View in:
PubMed Mentions:
1 Fields:
Translation:
Animals
-
PGC-1β deficiency accelerates the transition to heart failure in pressure overload hypertrophy. Circ Res. 2011 Sep 16; 109(7):783-93.
Riehle C, Wende AR, Zaha VG, Pires KM, Wayment B, Olsen C, Bugger H, Buchanan J, Wang X, Moreira AB, Doenst T, Medina-Gomez G, Litwin SE, Lelliott CJ, Vidal-Puig A, Abel ED. PMID: 21799152; PMCID: PMC3175248.
View in:
PubMed Mentions:
84 Fields:
Translation:
AnimalsCells
-
Expression of slow skeletal TnI in adult mouse hearts confers metabolic protection to ischemia. J Mol Cell Cardiol. 2011 Aug; 51(2):236-43.
Pound KM, Arteaga GM, Fasano M, Wilder T, Fischer SK, Warren CM, Wende AR, Farjah M, Abel ED, Solaro RJ, Lewandowski ED. PMID: 21640727; PMCID: PMC3124599.
View in:
PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
-
Central leptin signaling is required to normalize myocardial fatty acid oxidation rates in caloric-restricted ob/ob mice. Diabetes. 2011 May; 60(5):1424-34.
Sloan C, Tuinei J, Nemetz K, Frandsen J, Soto J, Wride N, Sempokuya T, Alegria L, Bugger H, Abel ED. PMID: 21441440; PMCID: PMC3292315.
View in:
PubMed Mentions:
47 Fields:
Translation:
AnimalsCells
-
Spotlight on metabolic remodelling in heart failure. Cardiovasc Res. 2011 May 01; 90(2):191-3.
Doenst T, Abel ED. PMID: 21429943.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimals
-
Obesity stresses cardiac mitochondria even when you are young. J Am Coll Cardiol. 2011 Feb 01; 57(5):586-9.
Abel ED. PMID: 21272750.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
-
Mitochondrial adaptations to physiological vs. pathological cardiac hypertrophy. Cardiovasc Res. 2011 May 01; 90(2):234-42.
Abel ED, Doenst T. PMID: 21257612; PMCID: PMC3115280.
View in:
PubMed Mentions:
142 Fields:
Translation:
HumansAnimalsCells
-
Fasting-induced reductions in cardiovascular and metabolic variables occur sooner in obese versus lean mice. Exp Biol Med (Maywood). 2010 Dec; 235(12):1489-97.
Tanner JM, Kearns DT, Kim BJ, Sloan C, Jia Z, Yang T, Abel ED, Symons JD. PMID: 21127345; PMCID: PMC3367312.
View in:
PubMed Mentions:
7 Fields:
Translation:
Animals
-
Knockout of insulin receptors in cardiomyocytes attenuates coronary arterial dysfunction induced by pressure overload. Am J Physiol Heart Circ Physiol. 2011 Jan; 300(1):H374-81.
Symons JD, Hu P, Yang Y, Wang X, Zhang QJ, Wende AR, Sloan CL, Sena S, Abel ED, Litwin SE. PMID: 20971769; PMCID: PMC3023253.
View in:
PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
-
PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation. J Clin Invest. 2010 Oct; 120(10):3443-54.
Son NH, Yu S, Tuinei J, Arai K, Hamai H, Homma S, Shulman GI, Abel ED, Goldberg IJ. PMID: 20852389; PMCID: PMC2947216.
View in:
PubMed Mentions:
98 Fields:
Translation:
AnimalsCells
-
Free fatty acid oxidation in insulin resistance and obesity. Heart Metab. 2010 Sep 01; 48:5-10.
Abel ED. PMID: 23646039; PMCID: PMC3643515.
View in:
PubMed Mentions:
13
-
An APPL1-AMPK signaling axis mediates beneficial metabolic effects of adiponectin in the heart. Am J Physiol Endocrinol Metab. 2010 Nov; 299(5):E721-9.
Fang X, Palanivel R, Cresser J, Schram K, Ganguly R, Thong FS, Tuinei J, Xu A, Abel ED, Sweeney G. PMID: 20739511; PMCID: PMC2980363.
View in:
PubMed Mentions:
52 Fields:
Translation:
AnimalsCells
-
Mitochondria in the diabetic heart. Cardiovasc Res. 2010 Nov 01; 88(2):229-40.
Bugger H, Abel ED. PMID: 20639213; PMCID: PMC2952534.
View in:
PubMed Mentions:
121 Fields:
Translation:
HumansAnimalsCells
-
Preferential oxidation of triacylglyceride-derived fatty acids in heart is augmented by the nuclear receptor PPARalpha. Circ Res. 2010 Jul 23; 107(2):233-41.
Banke NH, Wende AR, Leone TC, O'Donnell JM, Abel ED, Kelly DP, Lewandowski ED. PMID: 20522803; PMCID: PMC2921193.
View in:
PubMed Mentions:
84 Fields:
Translation:
AnimalsCells
-
Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents. J Clin Invest. 2010 May; 120(5):1506-14.
Shimizu I, Minamino T, Toko H, Okada S, Ikeda H, Yasuda N, Tateno K, Moriya J, Yokoyama M, Nojima A, Koh GY, Akazawa H, Shiojima I, Kahn CR, Abel ED, Komuro I. PMID: 20407209; PMCID: PMC2860916.
View in:
PubMed Mentions:
115 Fields:
Translation:
AnimalsCells
-
Diabetic cardiomyopathy, causes and effects. Rev Endocr Metab Disord. 2010 Mar; 11(1):31-9.
Boudina S, Abel ED. PMID: 20180026; PMCID: PMC2914514.
View in:
PubMed Mentions:
332 Fields:
Translation:
HumansCells
-
Nuclear receptor SHP, a death receptor that targets mitochondria, induces apoptosis and inhibits tumor growth. Mol Cell Biol. 2010 Mar; 30(6):1341-56.
Zhang Y, Soto J, Park K, Viswanath G, Kuwada S, Abel ED, Wang L. PMID: 20065042; PMCID: PMC2832505.
View in:
PubMed Mentions:
66 Fields:
Translation:
AnimalsCells
-
Insulin signaling regulates mitochondrial function in pancreatic beta-cells. PLoS One. 2009 Nov 24; 4(11):e7983.
Liu S, Okada T, Assmann A, Soto J, Liew CW, Bugger H, Shirihai OS, Abel ED, Kulkarni RN. PMID: 19956695; PMCID: PMC2776992.
View in:
PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
-
Mammalian target of rapamycin is a critical regulator of cardiac hypertrophy in spontaneously hypertensive rats. Hypertension. 2009 Dec; 54(6):1321-7.
Soesanto W, Lin HY, Hu E, Lefler S, Litwin SE, Sena S, Abel ED, Symons JD, Jalili T. PMID: 19884565; PMCID: PMC2803027.
View in:
PubMed Mentions:
55 Fields:
Translation:
AnimalsCells
-
Lipotoxicity in the heart. Biochim Biophys Acta. 2010 Mar; 1801(3):311-9.
Wende AR, Abel ED. PMID: 19818871; PMCID: PMC2823976.
View in:
PubMed Mentions:
141 Fields:
Translation:
HumansAnimals
-
Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy. J Mol Cell Cardiol. 2009 Nov; 47(5):664-75.
Ikeda H, Shiojima I, Ozasa Y, Yoshida M, Holzenberger M, Kahn CR, Walsh K, Igarashi T, Abel ED, Komuro I. PMID: 19744489; PMCID: PMC4886750.
View in:
PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
-
Rodent models of diabetic cardiomyopathy. Dis Model Mech. 2009 Sep-Oct; 2(9-10):454-66.
Bugger H, Abel ED. PMID: 19726805.
View in:
PubMed Mentions:
140 Fields:
Translation:
HumansAnimals
-
Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice. Diabetes. 2009 Sep; 58(9):1986-97.
Bugger H, Chen D, Riehle C, Soto J, Theobald HA, Hu XX, Ganesan B, Weimer BC, Abel ED. PMID: 19542201; PMCID: PMC2731527.
View in:
PubMed Mentions:
94 Fields:
Translation:
AnimalsCells
-
Endothelial nitric oxide synthase phosphorylation in treadmill-running mice: role of vascular signalling kinases. J Physiol. 2009 Aug 01; 587(Pt 15):3911-20.
Zhang QJ, McMillin SL, Tanner JM, Palionyte M, Abel ED, Symons JD. PMID: 19505983; PMCID: PMC2746618.
View in:
PubMed Mentions:
67 Fields:
Translation:
AnimalsCells
-
Cerebellar neurons possess a vesicular compartment structurally and functionally similar to Glut4-storage vesicles from peripheral insulin-sensitive tissues. J Neurosci. 2009 Apr 22; 29(16):5193-201.
Bakirtzi K, Belfort G, Lopez-Coviella I, Kuruppu D, Cao L, Abel ED, Brownell AL, Kandror KV. PMID: 19386915; PMCID: PMC2692175.
View in:
PubMed Mentions:
28 Fields:
Translation:
AnimalsCells
-
Impaired insulin signaling accelerates cardiac mitochondrial dysfunction after myocardial infarction. J Mol Cell Cardiol. 2009 Jun; 46(6):910-8.
Sena S, Hu P, Zhang D, Wang X, Wayment B, Olsen C, Avelar E, Abel ED, Litwin SE. PMID: 19249310; PMCID: PMC2683200.
View in:
PubMed Mentions:
35 Fields:
Translation:
AnimalsCells
-
Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart. Circulation. 2009 Mar 10; 119(9):1272-83.
Boudina S, Bugger H, Sena S, O'Neill BT, Zaha VG, Ilkun O, Wright JJ, Mazumder PK, Palfreyman E, Tidwell TJ, Theobald H, Khalimonchuk O, Wayment B, Sheng X, Rodnick KJ, Centini R, Chen D, Litwin SE, Weimer BE, Abel ED. PMID: 19237663; PMCID: PMC2739097.
View in:
PubMed Mentions:
148 Fields:
Translation:
AnimalsCells
-
The role of mPer2 clock gene in glucocorticoid and feeding rhythms. Endocrinology. 2009 May; 150(5):2153-60.
Yang S, Liu A, Weidenhammer A, Cooksey RC, McClain D, Kim MK, Aguilera G, Abel ED, Chung JH. PMID: 19179447; PMCID: PMC2671901.
View in:
PubMed Mentions:
107 Fields:
Translation:
Animals
-
Mechanisms for increased myocardial fatty acid utilization following short-term high-fat feeding. Cardiovasc Res. 2009 May 01; 82(2):351-60.
Wright JJ, Kim J, Buchanan J, Boudina S, Sena S, Bakirtzi K, Ilkun O, Theobald HA, Cooksey RC, Kandror KV, Abel ED. PMID: 19147655; PMCID: PMC2675931.
View in:
PubMed Mentions:
92 Fields:
Translation:
AnimalsCells
-
Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy. Mol Endocrinol. 2008 Nov; 22(11):2531-43.
Kim J, Wende AR, Sena S, Theobald HA, Soto J, Sloan C, Wayment BE, Litwin SE, Holzenberger M, LeRoith D, Abel ED. PMID: 18801929; PMCID: PMC2582541.
View in:
PubMed Mentions:
100 Fields:
Translation:
AnimalsCells
-
Hearts lacking caveolin-1 develop hypertrophy with normal cardiac substrate metabolism. Cell Cycle. 2008 Aug 15; 7(16):2509-18.
Augustus AS, Buchanan J, Gutman E, Rengo G, Pestell RG, Fortina P, Koch WJ, Bensadoun A, Abel ED, Lisanti MP. PMID: 18719368.
View in:
PubMed Mentions:
7 Fields:
Translation:
Animals
-
Reversal of oxidative stress in endothelial cells by controlled release of adiponectin. J Control Release. 2008 Sep 24; 130(3):234-7.
Mossalam M, Jeong JH, Abel ED, Kim SW, Kim YH. PMID: 18619503.
View in:
PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
-
Substrate uptake and metabolism are preserved in hypertrophic caveolin-3 knockout hearts. Am J Physiol Heart Circ Physiol. 2008 Aug; 295(2):H657-66.
Augustus AS, Buchanan J, Addya S, Rengo G, Pestell RG, Fortina P, Koch WJ, Bensadoun A, Abel ED, Lisanti MP. PMID: 18552160; PMCID: PMC2519224.
View in:
PubMed Mentions:
12 Fields:
Translation:
Animals
-
Ceramide is a cardiotoxin in lipotoxic cardiomyopathy. J Lipid Res. 2008 Oct; 49(10):2101-12.
Park TS, Hu Y, Noh HL, Drosatos K, Okajima K, Buchanan J, Tuinei J, Homma S, Jiang XC, Abel ED, Goldberg IJ. PMID: 18515784; PMCID: PMC2533410.
View in:
PubMed Mentions:
203 Fields:
Translation:
HumansAnimalsCells
-
Captopril normalizes insulin signaling and insulin-regulated substrate metabolism in obese (ob/ob) mouse hearts. Endocrinology. 2008 Aug; 149(8):4043-50.
Tabbi-Anneni I, Buchanan J, Cooksey RC, Abel ED. PMID: 18450963; PMCID: PMC2488224.
View in:
PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
-
Cardiac remodeling in obesity. Physiol Rev. 2008 Apr; 88(2):389-419.
Abel ED, Litwin SE, Sweeney G. PMID: 18391168; PMCID: PMC2915933.
View in:
PubMed Mentions:
303 Fields:
Translation:
HumansAnimals
-
Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis. Circulation. 2008 Mar 18; 117(11):1414-22.
Yin Z, Jones GN, Towns WH, Zhang X, Abel ED, Binkley PF, Jarjoura D, Kirschner LS. PMID: 18316483.
View in:
PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
-
Iron-mediated inhibition of mitochondrial manganese uptake mediates mitochondrial dysfunction in a mouse model of hemochromatosis. Mol Med. 2008 Mar-Apr; 14(3-4):98-108.
Jouihan HA, Cobine PA, Cooksey RC, Hoagland EA, Boudina S, Abel ED, Winge DR, McClain DA. PMID: 18317567; PMCID: PMC2258172.
View in:
PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
-
Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome. Clin Sci (Lond). 2008 Feb; 114(3):195-210.
Bugger H, Abel ED. PMID: 18184113.
View in:
PubMed Mentions:
100 Fields:
Translation:
HumansAnimalsCells
-
Mitochondrial fusion and function in Charcot-Marie-Tooth type 2A patient fibroblasts with mitofusin 2 mutations. Exp Neurol. 2008 May; 211(1):115-27.
Amiott EA, Lott P, Soto J, Kang PB, McCaffery JM, DiMauro S, Abel ED, Flanigan KM, Lawson VH, Shaw JM. PMID: 18316077; PMCID: PMC2409111.
View in:
PubMed Mentions:
42 Fields:
Translation:
HumansCells
-
A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy. Cell Metab. 2007 Oct; 6(4):294-306.
O'Neill BT, Kim J, Wende AR, Theobald HA, Tuinei J, Buchanan J, Guo A, Zaha VG, Davis DK, Schell JC, Boudina S, Wayment B, Litwin SE, Shioi T, Izumo S, Birnbaum MJ, Abel ED. PMID: 17908558; PMCID: PMC2084219.
View in:
PubMed Mentions:
68 Fields:
Translation:
AnimalsCells
-
PAS kinase is required for normal cellular energy balance. Proc Natl Acad Sci U S A. 2007 Sep 25; 104(39):15466-71.
Hao HX, Cardon CM, Swiatek W, Cooksey RC, Smith TL, Wilde J, Boudina S, Abel ED, McClain DA, Rutter J. PMID: 17878307; PMCID: PMC2000499.
View in:
PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
-
Cardiac hypertrophy caused by peroxisome proliferator- activated receptor-gamma agonist treatment occurs independently of changes in myocardial insulin signaling. Endocrinology. 2007 Dec; 148(12):6047-53.
Sena S, Rasmussen IR, Wende AR, McQueen AP, Theobald HA, Wilde N, Pereira RO, Litwin SE, Berger JP, Abel ED. PMID: 17823261.
View in:
PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
-
Glucose for the aging heart? Circulation. 2007 Aug 21; 116(8):884-7.
Abel ED. PMID: 17709649.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
-
Diabetic cardiomyopathy revisited. Circulation. 2007 Jun 26; 115(25):3213-23.
Boudina S, Abel ED. PMID: 17592090.
View in:
PubMed Mentions:
650 Fields:
Translation:
HumansAnimalsCells
-
Recipes for creating animal models of diabetic cardiovascular disease. Circ Res. 2007 May 25; 100(10):1415-27.
Hsueh W, Abel ED, Breslow JL, Maeda N, Davis RC, Fisher EA, Dansky H, McClain DA, McIndoe R, Wassef MK, Rabadán-Diehl C, Goldberg IJ. PMID: 17525381.
View in:
PubMed Mentions:
106 Fields:
Translation:
HumansAnimals
-
Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1. Cell Metab. 2007 Feb; 5(2):129-42.
Sano M, Izumi Y, Helenius K, Asakura M, Rossi DJ, Xie M, Taffet G, Hu L, Pautler RG, Wilson CR, Boudina S, Abel ED, Taegtmeyer H, Scaglia F, Graham BH, Kralli A, Shimizu N, Tanaka H, Mäkelä TP, Schneider MD. PMID: 17276355.
View in:
PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
-
Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance. PLoS Biol. 2006 Nov; 4(11):e369.
Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Strömstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A. PMID: 17090215; PMCID: PMC1634886.
View in:
PubMed Mentions:
145 Fields:
Translation:
AnimalsCells
-
Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes. Physiology (Bethesda). 2006 Aug; 21:250-8.
Boudina S, Abel ED. PMID: 16868314.
View in:
PubMed Mentions:
75 Fields:
Translation:
HumansAnimalsCells
-
Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase. J Card Fail. 2006 Jun; 12(5):392-8.
Buerger A, Rozhitskaya O, Sherwood MC, Dorfman AL, Bisping E, Abel ED, Pu WT, Izumo S, Jay PY. PMID: 16762803.
View in:
PubMed Mentions:
73 Fields:
Translation:
AnimalsCells
-
Loss of lipoprotein lipase-derived fatty acids leads to increased cardiac glucose metabolism and heart dysfunction. J Biol Chem. 2006 Mar 31; 281(13):8716-23.
Augustus AS, Buchanan J, Park TS, Hirata K, Noh HL, Sun J, Homma S, D'armiento J, Abel ED, Goldberg IJ. PMID: 16410253.
View in:
PubMed Mentions:
57 Fields:
Translation:
AnimalsCells
-
Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity. Circulation. 2005 Oct 25; 112(17):2686-95.
Boudina S, Sena S, O'Neill BT, Tathireddy P, Young ME, Abel ED. PMID: 16246967.
View in:
PubMed Mentions:
245 Fields:
Translation:
AnimalsCells
-
Contractile dysfunction in hypertrophied hearts with deficient insulin receptor signaling: possible role of reduced capillary density. J Mol Cell Cardiol. 2005 Dec; 39(6):882-92.
McQueen AP, Zhang D, Hu P, Swenson L, Yang Y, Zaha VG, Hoffman JL, Yun UJ, Chakrabarti G, Wang Z, Albertine KH, Abel ED, Litwin SE. PMID: 16216265.
View in:
PubMed Mentions:
35 Fields:
Translation:
HumansAnimalsCells
-
Akt1 in the cardiovascular system: friend or foe? J Clin Invest. 2005 Aug; 115(8):2059-64.
O'Neill BT, Abel ED. PMID: 16075047; PMCID: PMC1180557.
View in:
PubMed Mentions:
53 Fields:
Translation:
HumansAnimalsCells
-
The intrinsic circadian clock within the cardiomyocyte. Am J Physiol Heart Circ Physiol. 2005 Oct; 289(4):H1530-41.
Durgan DJ, Hotze MA, Tomlin TM, Egbejimi O, Graveleau C, Abel ED, Shaw CA, Bray MS, Hardin PE, Young ME. PMID: 15937094.
View in:
PubMed Mentions:
80 Fields:
Translation:
AnimalsCells
-
Myocardial insulin resistance and cardiac complications of diabetes. Curr Drug Targets Immune Endocr Metabol Disord. 2005 Jun; 5(2):219-26.
Abel ED. PMID: 16089356.
View in:
PubMed Mentions:
29 Fields:
Translation:
HumansAnimals
-
Insulin signaling in heart muscle: lessons from genetically engineered mouse models. Curr Hypertens Rep. 2004 Dec; 6(6):416-23.
Abel ED. PMID: 15527684.
View in:
PubMed Mentions:
19 Fields:
Translation:
Animals
-
Glucose transport in the heart. Front Biosci. 2004 Jan 01; 9:201-15.
Abel ED. PMID: 14766360.
View in:
PubMed Mentions:
90 Fields:
Translation:
HumansAnimals
-
An unliganded thyroid hormone receptor causes severe neurological dysfunction. Proc Natl Acad Sci U S A. 2001 Mar 27; 98(7):3998-4003.
Hashimoto K, Curty FH, Borges PP, Lee CE, Abel ED, Elmquist JK, Cohen RN, Wondisford FE. PMID: 11274423; PMCID: PMC31168.
View in:
PubMed Mentions:
69 Fields:
Translation:
Animals