Andrew Goldstein

Title(s)Associate Professor, Molecular, Cell and Developmental Biology
SchoolCollege of Letters and Science
ORCID ORCID Icon0000-0003-0434-9149 Additional info
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    Title(s)Associate Professor, Urology

    Collapse Biography 
    Collapse Education and Training
    Dartmouth College, Hanover, NHBA06/05Biochemistry and Molecular Biology
    University of California, Los Angeles, Los Angeles, CAPhD06/11Molecular Biology
    Collapse Awards and Honors
    UCLA Division of Life Sciences2024Excellence in Research Award
    Department of Defense2023  - 2026Prostate Cancer Research Program Idea Development Award
    University of California Cancer Research Coordinating Committee2022  - 2023Faculty Seed Grant
    UCLA Broad Stem Cell Research Center2022  - 2023Innovation Award
    Metabolism in Health and Disease Conference2022Rheos Medicine Short Talk Award
    Department of Defense2021  - 2022Kidney Cancer Research Program Concept Award
    UCLA Jonsson Comprehensive Cancer Center and Broad Stem Cell Research Center2021  - 2024Ablon Scholars Award
    NIH/NCI2019  - 2024R01
    Society for Basic Urologic Research2019Young Investigator Award
    Rose Hills Foundation 2019  - 2020Innovator Award
    American Cancer Society2018Giants of Science Hope Award
    American Cancer Society2017  - 2021Research Scholar Grant
    Margaret E Early Medical Research Trust2017  - 2019Research Award
    STOP CANCER2017  - 2019Research Career Development Award
    Department of Defense2013  - 2016Prostate Cancer Research Program Idea Development Award
    Prostate Cancer Foundation2011  - 2014Young Investigator Award

    Collapse Overview 
    Collapse Overview
    The research in the Goldstein laboratory is focused on understanding the role of prostate epithelial cells in development, reproduction, aging and tumorigenesis. Dr. Goldstein described the isolation of epithelial progenitor cells from mouse and human prostate tissue and demonstrated the capacity of progenitor cells to initiate prostate cancer in response to oncogenic transformation. Following up on this work, Dr. Goldstein and colleagues determined that prostate cancer can evolve from a basal cell of origin to a luminal-like tumor-propagating cell population. The Goldstein lab has demonstrated that chronic inflammation in the human prostate is associated with an expansion of rare progenitor-like luminal cells marked by low CD38 expression that can initiate aggressive prostate cancer. These findings help to explain why chronic inflammation increases prostate cancer risk. The lab has determined that luminal progenitor cells are increased in the aging mouse and human prostate and that aging signatures indicate age-related metabolic reprogramming of prostate epithelial cells. Most recently, the lab has defined a role for MYC in treatment-induced metabolic reprogramming in prostate cancer and found that prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment. The lab continues to interrogate the mechanisms responsible for prostate development, aging, and cancer initiation.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A metabolic-epigenetic mechanism directs cell fate and therapeutic sensitivity in breast cancer. Cancer Res. 2024 Feb 08. Bernard MJ, Goldstein AS. PMID: 38330100.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    2. Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment. Nat Cell Biol. 2023 Dec; 25(12):1821-1832. Giafaglione JM, Crowell PD, Delcourt AML, Hashimoto T, Ha SM, Atmakuri A, Nunley NM, Dang RMA, Tian M, Diaz JA, Tika E, Payne MC, Burkhart DL, Li D, Navone NM, Corey E, Nelson PS, Lin NYC, Blanpain C, Ellis L, Boutros PC, Goldstein AS. PMID: 38049604; PMCID: PMC10709144.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    3. A conserved mechanism for JNK-mediated loss of Notch function in advanced prostate cancer. Sci Signal. 2023 11 07; 16(810):eabo5213. Wang CW, Clémot M, Hashimoto T, Diaz JA, Goins LM, Goldstein AS, Nagaraj R, Banerjee U. PMID: 37934809; PMCID: PMC10802904.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. MYC is a regulator of androgen receptor inhibition-induced metabolic requirements in prostate cancer. Cell Rep. 2023 10 31; 42(10):113221. Crowell PD, Giafaglione JM, Jones AE, Nunley NM, Hashimoto T, Delcourt AML, Petcherski A, Agrawal R, Bernard MJ, Diaz JA, Heering KY, Huang RR, Low JY, Matulionis N, Navone NM, Ye H, Zoubeidi A, Christofk HR, Rettig MB, Reiter RE, Haffner MC, Boutros PC, Shirihai OS, Divakaruni AS, Goldstein AS. PMID: 37815914.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    5. Prostatic proliferative inflammatory atrophy: welcome to the club†. J Pathol. 2023 12; 261(4):375-377. Bernard MJ, Smith CM, Goldstein AS. PMID: 37775958; PMCID: PMC10840725.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Highly multiplexed immune profiling throughout adulthood reveals kinetics of lymphocyte infiltration in the aging mouse prostate. Aging (Albany NY). 2023 05 13; 15(9):3356-3380. Fox JJ, Hashimoto T, Navarro HI, Garcia AJ, Shou BL, Goldstein AS. PMID: 37179121; PMCID: PMC10449296.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    7. Microwell-based flow culture increases viability and restores drug response in prostate cancer spheroids. Biotechnol J. 2023 Jun; 18(6):e2200434. Payne MC, Ho S, Hashimoto T, Imboden S, Diaz JA, Lee BS, Rupert MJ, Cai NY, Goldstein AS, Lin NYC. PMID: 36905340.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    8. Aging of the progenitor cells that initiate prostate cancer. Cancer Lett. 2021 09 01; 515:28-35. Freeland J, Crowell PD, Giafaglione JM, Boutros PC, Goldstein AS. PMID: 34052326; PMCID: PMC8494000.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    9. Distinct cell-types in the prostate share an aging signature suggestive of metabolic reprogramming. Am J Clin Exp Urol. 2020; 8(4):140-151. Crowell PD, Giafaglione JM, Hashimoto T, Goldstein AS. PMID: 32929410; PMCID: PMC7486537.
      View in: PubMed   Mentions: 6  
    10. Targeting cellular heterogeneity with CXCR2 blockade for the treatment of therapy-resistant prostate cancer. Sci Transl Med. 2019 12 04; 11(521). Li Y, He Y, Butler W, Xu L, Chang Y, Lei K, Zhang H, Zhou Y, Gao AC, Zhang Q, Taylor DG, Cheng D, Farber-Katz S, Karam R, Landrith T, Li B, Wu S, Hsuan V, Yang Q, Hu H, Chen X, Flowers M, McCall SJ, Lee JK, Smith BA, Park JW, Goldstein AS, Witte ON, Wang Q, Rettig MB, Armstrong AJ, Cheng Q, Huang J. PMID: 31801883; PMCID: PMC7238624.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    11. Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture. J Vis Exp. 2019 11 22; (153). Crowell PD, Giafaglione JM, Hashimoto T, Diaz JA, Goldstein AS. PMID: 31814611; PMCID: PMC7423135.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    12. Mass cytometry reveals species-specific differences and a new level of complexity for immune cells in the prostate. Am J Clin Exp Urol. 2019; 7(4):281-296. Fox JJ, Navarro HI, Hashimoto T, Garcia AJ, Goldstein AS. PMID: 31511834; PMCID: PMC6734036.
      View in: PubMed   Mentions: 7  
    13. Expansion of Luminal Progenitor Cells in the Aging Mouse and Human Prostate. Cell Rep. 2019 08 06; 28(6):1499-1510.e6. Crowell PD, Fox JJ, Hashimoto T, Diaz JA, Navarro HI, Henry GH, Feldmar BA, Lowe MG, Garcia AJ, Wu YE, Sajed DP, Strand DW, Goldstein AS. PMID: 31390564; PMCID: PMC6710009.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    14. CD38 is methylated in prostate cancer and regulates extracellular NAD. Cancer Metab. 2018; 6:13. Mottahedeh J, Haffner MC, Grogan TR, Hashimoto T, Crowell PD, Beltran H, Sboner A, Bareja R, Esopi D, Isaacs WB, Yegnasubramanian S, Rettig MB, Elashoff DA, Platz EA, De Marzo AM, Teitell MA, Goldstein AS. PMID: 30258629; PMCID: PMC6150989.
      View in: PubMed   Mentions: 26  
    15. HoxB13 mediates AR-V7 activity in prostate cancer. Proc Natl Acad Sci U S A. 2018 06 26; 115(26):6528-6529. Navarro HI, Goldstein AS. PMID: 29891672; PMCID: PMC6042116.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    16. Functional evidence that progenitor cells near sites of inflammation are precursors for aggressive prostate cancer. Mol Cell Oncol. 2017; 4(2):e1279723. Crowell PD, Goldstein AS. PMID: 28401184; PMCID: PMC5383352.
      View in: PubMed   Mentions: 8  
    17. Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells that Can Initiate Human Prostate Cancer and Predict Poor Outcome. Cell Rep. 2016 12 06; 17(10):2596-2606. Liu X, Grogan TR, Hieronymus H, Hashimoto T, Mottahedeh J, Cheng D, Zhang L, Huang K, Stoyanova T, Park JW, Shkhyan RO, Nowroozizadeh B, Rettig MB, Sawyers CL, Elashoff D, Horvath S, Huang J, Witte ON, Goldstein AS. PMID: 27926864; PMCID: PMC5367888.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    18. Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2016 10 18; 113(42):E6457-E6466. Stoyanova T, Riedinger M, Lin S, Faltermeier CM, Smith BA, Zhang KX, Going CC, Goldstein AS, Lee JK, Drake JM, Rice MA, Hsu EC, Nowroozizadeh B, Castor B, Orellana SY, Blum SM, Cheng D, Pienta KJ, Reiter RE, Pitteri SJ, Huang J, Witte ON. PMID: 27694579; PMCID: PMC5081658.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    19. Tissue Recombination Models for the Study of Epithelial Cancer. Cold Spring Harb Protoc. 2015 Dec 02; 2015(12):pdb.top069880. Zong Y, Goldstein AS, Witte ON. PMID: 26631129.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    20. Dissociated Prostate Regeneration under the Renal Capsule. Cold Spring Harb Protoc. 2015 Nov 02; 2015(11):991-4. Zong Y, Goldstein AS, Witte ON. PMID: 26527760.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    21. Preparation of Urogenital Sinus Mesenchymal Cells for Prostate Tissue Recombination Models. Cold Spring Harb Protoc. 2015 Nov 02; 2015(11):988-90. Zong Y, Goldstein AS, Witte ON. PMID: 26527759.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    22. The many ways to make a luminal cell and a prostate cancer cell. Endocr Relat Cancer. 2015 Dec; 22(6):T187-97. Strand DW, Goldstein AS. PMID: 26307022; PMCID: PMC4893788.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    23. Inflammation promotes prostate differentiation. Proc Natl Acad Sci U S A. 2014 Feb 04; 111(5):1666-7. Liu X, Goldstein AS. PMID: 24459187; PMCID: PMC3918806.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    24. Distinct phases of human prostate cancer initiation and progression can be driven by different cell-types. Cancer Cell Microenviron. 2014; 1(3). Stoyanova T, Goldstein AS. PMID: 26005704; PMCID: PMC4441270.
      View in: PubMed   Mentions: 2  
    25. A symbiotic relationship between epithelial and stromal stem cells. Proc Natl Acad Sci U S A. 2013 Dec 17; 110(51):20356-7. Goldstein AS. PMID: 24284171; PMCID: PMC3870754.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    26. Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):20111-6. Stoyanova T, Cooper AR, Drake JM, Liu X, Armstrong AJ, Pienta KJ, Zhang H, Kohn DB, Huang J, Witte ON, Goldstein AS. PMID: 24282295; PMCID: PMC3864278.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    27. Does the microenvironment influence the cell types of origin for prostate cancer? Genes Dev. 2013 Jul 15; 27(14):1539-44. Goldstein AS, Witte ON. PMID: 23873937; PMCID: PMC3731542.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    28. The molecular basis for ethnic variation and histological subtype differences in prostate cancer. Sci China Life Sci. 2013 Sep; 56(9):780-7. Zong Y, Goldstein AS, Huang J. PMID: 23852643; PMCID: PMC4078990.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    29. Estrogen and progesterone together expand murine endometrial epithelial progenitor cells. Stem Cells. 2013 Apr; 31(4):808-22. Janzen DM, Cheng D, Schafenacker AM, Paik DY, Goldstein AS, Witte ON, Jaroszewicz A, Pellegrini M, Memarzadeh S. PMID: 23341289; PMCID: PMC3774116.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    30. Adaptation or selection--mechanisms of castration-resistant prostate cancer. Nat Rev Urol. 2013 Feb; 10(2):90-8. Zong Y, Goldstein AS. PMID: 23247694.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimals
    31. Identification, characterization and targeting of Docetaxel-resistant prostate cancer cells. Asian J Androl. 2013 Jan; 15(1):83-4. Stoyanova TI, Goldstein AS. PMID: 23202701; PMCID: PMC3739119.
      View in: PubMed   Mentions:    Fields:    
    32. A plethora of progenitors in the post-natal prostate. EMBO Rep. 2012 Dec; 13(12):1036-7. Goldstein AS, Witte ON. PMID: 23138032; PMCID: PMC3512412.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    33. Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via β-catenin signaling. Genes Dev. 2012 Oct 15; 26(20):2271-85. Stoyanova T, Goldstein AS, Cai H, Drake JM, Huang J, Witte ON. PMID: 23070813; PMCID: PMC3475800.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    34. Identification of CD166 as a surface marker for enriching prostate stem/progenitor and cancer initiating cells. PLoS One. 2012; 7(8):e42564. Jiao J, Hindoyan A, Wang S, Tran LM, Goldstein AS, Lawson D, Chen D, Li Y, Guo C, Zhang B, Fazli L, Gleave M, Witte ON, Garraway IP, Wu H. PMID: 22880034; PMCID: PMC3411798.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    35. Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression. Proc Natl Acad Sci U S A. 2012 Jan 31; 109(5):1643-8. Drake JM, Graham NA, Stoyanova T, Sedghi A, Goldstein AS, Cai H, Smith DA, Zhang H, Komisopoulou E, Huang J, Graeber TG, Witte ON. PMID: 22307624; PMCID: PMC3277127.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    36. Purification and direct transformation of epithelial progenitor cells from primary human prostate. Nat Protoc. 2011 May; 6(5):656-67. Goldstein AS, Drake JM, Burnes DL, Finley DS, Zhang H, Reiter RE, Huang J, Witte ON. PMID: 21527922; PMCID: PMC3092477.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    37. A two-step toward personalized therapies for prostate cancer. Sci Transl Med. 2011 Mar 02; 3(72):72ps7. Goldstein AS, Zong Y, Witte ON. PMID: 21368221; PMCID: PMC3089975.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    38. Cell-autonomous activation of the PI3-kinase pathway initiates endometrial cancer from adult uterine epithelium. Proc Natl Acad Sci U S A. 2010 Oct 05; 107(40):17298-303. Memarzadeh S, Zong Y, Janzen DM, Goldstein AS, Cheng D, Kurita T, Schafenacker AM, Huang J, Witte ON. PMID: 20855612; PMCID: PMC2951427.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    39. Identification of a cell of origin for human prostate cancer. Science. 2010 Jul 30; 329(5991):568-71. Goldstein AS, Huang J, Guo C, Garraway IP, Witte ON. PMID: 20671189; PMCID: PMC2917982.
      View in: PubMed   Mentions: 321     Fields:    Translation:HumansAnimalsCells
    40. Primitive origins of prostate cancer: in vivo evidence for prostate-regenerating cells and prostate cancer-initiating cells. Mol Oncol. 2010 Oct; 4(5):385-96. Goldstein AS, Stoyanova T, Witte ON. PMID: 20688584; PMCID: PMC2939195.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    41. Responses to the proposed DSM-V changes. J Sex Med. 2010 Jun; 7(6):1998-2014. Derogatis LR, Laan E, Brauer M, Van Lunsen RHW, Jannini EA, Davis SR, Fabre L, Smith LC, Basson R, Guay AT, Rubio-Aurioles E, Goldstein A, Pukall C, Kellogg S, Burrows L, Morrison P, Krychman M, Goldstein SW, Goldstein I. PMID: 20929516.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    42. Human prostate sphere-forming cells represent a subset of basal epithelial cells capable of glandular regeneration in vivo. Prostate. 2010 Apr 01; 70(5):491-501. Garraway IP, Sun W, Tran CP, Perner S, Zhang B, Goldstein AS, Hahm SA, Haider M, Head CS, Reiter RE, Rubin MA, Witte ON. PMID: 19938015; PMCID: PMC2885946.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansCells
    43. Isolation, cultivation and characterization of adult murine prostate stem cells. Nat Protoc. 2010 Apr; 5(4):702-13. Lukacs RU, Goldstein AS, Lawson DA, Cheng D, Witte ON. PMID: 20360765; PMCID: PMC2943378.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    44. ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate cells. Proc Natl Acad Sci U S A. 2009 Jul 28; 106(30):12465-70. Zong Y, Xin L, Goldstein AS, Lawson DA, Teitell MA, Witte ON. PMID: 19592505; PMCID: PMC2708977.
      View in: PubMed   Mentions: 112     Fields:    Translation:AnimalsCells
    45. Trop2 identifies a subpopulation of murine and human prostate basal cells with stem cell characteristics. Proc Natl Acad Sci U S A. 2008 Dec 30; 105(52):20882-7. Goldstein AS, Lawson DA, Cheng D, Sun W, Garraway IP, Witte ON. PMID: 19088204; PMCID: PMC2603432.
      View in: PubMed   Mentions: 197     Fields:    Translation:HumansAnimalsCells
    46. Epithelial stem cells of the prostate and their role in cancer progression. Cold Spring Harb Symp Quant Biol. 2008; 73:491-502. Lukacs RU, Lawson DA, Xin L, Zong Y, Garraway I, Goldstein AS, Memarzadeh S, Witte ON. PMID: 19022743.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
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