Andrew Goldstein

Title(s)Associate Professor, Molecular, Cell and Developmental Biology
SchoolCollege of Letters and Science
ORCID ORCID Icon0000-0003-0434-9149 Additional info
vCardDownload vCard
    Other Positions
    Title(s)Associate Professor, Urology


    Collapse Biography 
    Collapse Education and Training
    Dartmouth College, Hanover, NHBA06/05Biochemistry and Molecular Biology
    University of California, Los Angeles, Los Angeles, CAPhD06/11Molecular Biology
    Collapse Awards and Honors
    Department of Defense2023  - 2026Prostate Cancer Research Program Idea Development Award
    University of California Cancer Research Coordinating Committee2022  - 2023Faculty Seed Grant
    UCLA Broad Stem Cell Research Center2022  - 2023Innovation Award
    Metabolism in Health and Disease Conference2022Rheos Medicine Short Talk Award
    Department of Defense2021  - 2022Kidney Cancer Research Program Concept Award
    UCLA Jonsson Comprehensive Cancer Center and Broad Stem Cell Research Center2021  - 2024Ablon Scholars Award
    NIH/NCI2019  - 2024R01
    Society for Basic Urologic Research2019Young Investigator Award
    Rose Hills Foundation 2019  - 2020Innovator Award
    American Cancer Society2018Giants of Science Hope Award
    American Cancer Society2017  - 2021Research Scholar Grant
    Margaret E Early Medical Research Trust2017  - 2019Research Award
    STOP CANCER2017  - 2019Research Career Development Award
    Department of Defense2013  - 2016Prostate Cancer Research Program Idea Development Award
    Prostate Cancer Foundation2011  - 2014Young Investigator Award

    Collapse Overview 
    Collapse Overview
    The research in the Goldstein laboratory is focused on the intersection between cancer biology, stem cell biology and metabolism. During his graduate work, Dr. Goldstein described the isolation of epithelial progenitor cells from mouse and human prostate tissue and demonstrated the capacity of progenitor cells to initiate prostate cancer in response to oncogenic transformation. Following up on this work, Dr. Goldstein and colleagues determined that prostate cancer can evolve from a basal cell of origin to a luminal-like tumor-propagating cell population. More recently, the Goldstein laboratory has been investigating the interplay between aging, epithelial progenitor cells, and tumorigenesis, using a combination of mouse and human tissue models. The main goals of the lab are to elucidate the cellular and molecular mechanisms promoting epithelial cancer initiation, progression and resistance to treatment.

    Collapse Featured Content 
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Aging of the progenitor cells that initiate prostate cancer. Cancer Lett. 2021 09 01; 515:28-35. Freeland J, Crowell PD, Giafaglione JM, Boutros PC, Goldstein AS. PMID: 34052326; PMCID: PMC8494000.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    2. Distinct cell-types in the prostate share an aging signature suggestive of metabolic reprogramming. Am J Clin Exp Urol. 2020; 8(4):140-151. Crowell PD, Giafaglione JM, Hashimoto T, Goldstein AS. PMID: 32929410; PMCID: PMC7486537.
      View in: PubMed   Mentions: 5  
    3. Assessing the feasibility of a rapid, high-volume cervical cancer screening programme using HPV self-sampling and digital colposcopy in rural regions of Yunnan, China. BMJ Open. 2020 03 30; 10(3):e035153. Goldstein A, Goldstein LS, Lipson R, Bedell S, Wang J, Stamper SA, Brenner G, Goldstein GR, O'Keefe KD, O'Keefe SC, O'Keefe M, O'Keefe T, Goldstein AR, Zhao A. PMID: 32234744; PMCID: PMC7170644.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    4. Targeting cellular heterogeneity with CXCR2 blockade for the treatment of therapy-resistant prostate cancer. Sci Transl Med. 2019 12 04; 11(521). Li Y, He Y, Butler W, Xu L, Chang Y, Lei K, Zhang H, Zhou Y, Gao AC, Zhang Q, Taylor DG, Cheng D, Farber-Katz S, Karam R, Landrith T, Li B, Wu S, Hsuan V, Yang Q, Hu H, Chen X, Flowers M, McCall SJ, Lee JK, Smith BA, Park JW, Goldstein AS, Witte ON, Wang Q, Rettig MB, Armstrong AJ, Cheng Q, Huang J. PMID: 31801883; PMCID: PMC7238624.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    5. Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture. J Vis Exp. 2019 Nov 22; (153). Crowell PD, Giafaglione JM, Hashimoto T, Diaz JA, Goldstein AS. PMID: 31814611; PMCID: PMC7423135.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    6. Mass cytometry reveals species-specific differences and a new level of complexity for immune cells in the prostate. Am J Clin Exp Urol. 2019; 7(4):281-296. Fox JJ, Navarro HI, Hashimoto T, Garcia AJ, Goldstein AS. PMID: 31511834; PMCID: PMC6734036.
      View in: PubMed   Mentions: 4  
    7. Expansion of Luminal Progenitor Cells in the Aging Mouse and Human Prostate. Cell Rep. 2019 08 06; 28(6):1499-1510.e6. Crowell PD, Fox JJ, Hashimoto T, Diaz JA, Navarro HI, Henry GH, Feldmar BA, Lowe MG, Garcia AJ, Wu YE, Sajed DP, Strand DW, Goldstein AS. PMID: 31390564; PMCID: PMC6710009.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    8. CD38 is methylated in prostate cancer and regulates extracellular NAD. Cancer Metab. 2018; 6:13. Mottahedeh J, Haffner MC, Grogan TR, Hashimoto T, Crowell PD, Beltran H, Sboner A, Bareja R, Esopi D, Isaacs WB, Yegnasubramanian S, Rettig MB, Elashoff DA, Platz EA, De Marzo AM, Teitell MA, Goldstein AS. PMID: 30258629; PMCID: PMC6150989.
      View in: PubMed   Mentions: 23  
    9. HoxB13 mediates AR-V7 activity in prostate cancer. Proc Natl Acad Sci U S A. 2018 06 26; 115(26):6528-6529. Navarro HI, Goldstein AS. PMID: 29891672; PMCID: PMC6042116.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    10. Functional evidence that progenitor cells near sites of inflammation are precursors for aggressive prostate cancer. Mol Cell Oncol. 2017; 4(2):e1279723. Crowell PD, Goldstein AS. PMID: 28401184; PMCID: PMC5383352.
      View in: PubMed   Mentions: 7  
    11. Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells that Can Initiate Human Prostate Cancer and Predict Poor Outcome. Cell Rep. 2016 12 06; 17(10):2596-2606. Liu X, Grogan TR, Hieronymus H, Hashimoto T, Mottahedeh J, Cheng D, Zhang L, Huang K, Stoyanova T, Park JW, Shkhyan RO, Nowroozizadeh B, Rettig MB, Sawyers CL, Elashoff D, Horvath S, Huang J, Witte ON, Goldstein AS. PMID: 27926864; PMCID: PMC5367888.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    12. Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2016 10 18; 113(42):E6457-E6466. Stoyanova T, Riedinger M, Lin S, Faltermeier CM, Smith BA, Zhang KX, Going CC, Goldstein AS, Lee JK, Drake JM, Rice MA, Hsu EC, Nowroozizadeh B, Castor B, Orellana SY, Blum SM, Cheng D, Pienta KJ, Reiter RE, Pitteri SJ, Huang J, Witte ON. PMID: 27694579; PMCID: PMC5081658.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    13. Tissue Recombination Models for the Study of Epithelial Cancer. Cold Spring Harb Protoc. 2015 Dec 02; 2015(12):pdb.top069880. Zong Y, Goldstein AS, Witte ON. PMID: 26631129.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    14. Dissociated Prostate Regeneration under the Renal Capsule. Cold Spring Harb Protoc. 2015 Nov 02; 2015(11):991-4. Zong Y, Goldstein AS, Witte ON. PMID: 26527760.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    15. Preparation of Urogenital Sinus Mesenchymal Cells for Prostate Tissue Recombination Models. Cold Spring Harb Protoc. 2015 Nov 02; 2015(11):988-90. Zong Y, Goldstein AS, Witte ON. PMID: 26527759.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    16. The many ways to make a luminal cell and a prostate cancer cell. Endocr Relat Cancer. 2015 Dec; 22(6):T187-97. Strand DW, Goldstein AS. PMID: 26307022; PMCID: PMC4893788.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    17. Inflammation promotes prostate differentiation. Proc Natl Acad Sci U S A. 2014 Feb 04; 111(5):1666-7. Liu X, Goldstein AS. PMID: 24459187; PMCID: PMC3918806.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    18. Distinct phases of human prostate cancer initiation and progression can be driven by different cell-types. Cancer Cell Microenviron. 2014; 1(3). Stoyanova T, Goldstein AS. PMID: 26005704; PMCID: PMC4441270.
      View in: PubMed   Mentions: 2  
    19. A symbiotic relationship between epithelial and stromal stem cells. Proc Natl Acad Sci U S A. 2013 Dec 17; 110(51):20356-7. Goldstein AS. PMID: 24284171; PMCID: PMC3870754.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    20. Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):20111-6. Stoyanova T, Cooper AR, Drake JM, Liu X, Armstrong AJ, Pienta KJ, Zhang H, Kohn DB, Huang J, Witte ON, Goldstein AS. PMID: 24282295; PMCID: PMC3864278.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansCells
    21. Does the microenvironment influence the cell types of origin for prostate cancer? Genes Dev. 2013 Jul 15; 27(14):1539-44. Goldstein AS, Witte ON. PMID: 23873937; PMCID: PMC3731542.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    22. The molecular basis for ethnic variation and histological subtype differences in prostate cancer. Sci China Life Sci. 2013 Sep; 56(9):780-7. Zong Y, Goldstein AS, Huang J. PMID: 23852643; PMCID: PMC4078990.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    23. Estrogen and progesterone together expand murine endometrial epithelial progenitor cells. Stem Cells. 2013 Apr; 31(4):808-22. Janzen DM, Cheng D, Schafenacker AM, Paik DY, Goldstein AS, Witte ON, Jaroszewicz A, Pellegrini M, Memarzadeh S. PMID: 23341289; PMCID: PMC3774116.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    24. Adaptation or selection--mechanisms of castration-resistant prostate cancer. Nat Rev Urol. 2013 Feb; 10(2):90-8. Zong Y, Goldstein AS. PMID: 23247694.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimals
    25. Identification, characterization and targeting of Docetaxel-resistant prostate cancer cells. Asian J Androl. 2013 Jan; 15(1):83-4. Stoyanova TI, Goldstein AS. PMID: 23202701; PMCID: PMC3739119.
      View in: PubMed   Mentions:    Fields:    
    26. A plethora of progenitors in the post-natal prostate. EMBO Rep. 2012 Dec; 13(12):1036-7. Goldstein AS, Witte ON. PMID: 23138032; PMCID: PMC3512412.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    27. Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via �-catenin signaling. Genes Dev. 2012 Oct 15; 26(20):2271-85. Stoyanova T, Goldstein AS, Cai H, Drake JM, Huang J, Witte ON. PMID: 23070813; PMCID: PMC3475800.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    28. Identification of CD166 as a surface marker for enriching prostate stem/progenitor and cancer initiating cells. PLoS One. 2012; 7(8):e42564. Jiao J, Hindoyan A, Wang S, Tran LM, Goldstein AS, Lawson D, Chen D, Li Y, Guo C, Zhang B, Fazli L, Gleave M, Witte ON, Garraway IP, Wu H. PMID: 22880034; PMCID: PMC3411798.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    29. Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression. Proc Natl Acad Sci U S A. 2012 Jan 31; 109(5):1643-8. Drake JM, Graham NA, Stoyanova T, Sedghi A, Goldstein AS, Cai H, Smith DA, Zhang H, Komisopoulou E, Huang J, Graeber TG, Witte ON. PMID: 22307624; PMCID: PMC3277127.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    30. Purification and direct transformation of epithelial progenitor cells from primary human prostate. Nat Protoc. 2011 May; 6(5):656-67. Goldstein AS, Drake JM, Burnes DL, Finley DS, Zhang H, Reiter RE, Huang J, Witte ON. PMID: 21527922; PMCID: PMC3092477.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    31. A two-step toward personalized therapies for prostate cancer. Sci Transl Med. 2011 Mar 02; 3(72):72ps7. Goldstein AS, Zong Y, Witte ON. PMID: 21368221; PMCID: PMC3089975.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    32. Cell-autonomous activation of the PI3-kinase pathway initiates endometrial cancer from adult uterine epithelium. Proc Natl Acad Sci U S A. 2010 Oct 05; 107(40):17298-303. Memarzadeh S, Zong Y, Janzen DM, Goldstein AS, Cheng D, Kurita T, Schafenacker AM, Huang J, Witte ON. PMID: 20855612; PMCID: PMC2951427.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    33. Identification of a cell of origin for human prostate cancer. Science. 2010 Jul 30; 329(5991):568-71. Goldstein AS, Huang J, Guo C, Garraway IP, Witte ON. PMID: 20671189; PMCID: PMC2917982.
      View in: PubMed   Mentions: 312     Fields:    Translation:HumansAnimalsCells
    34. Primitive origins of prostate cancer: in vivo evidence for prostate-regenerating cells and prostate cancer-initiating cells. Mol Oncol. 2010 Oct; 4(5):385-96. Goldstein AS, Stoyanova T, Witte ON. PMID: 20688584; PMCID: PMC2939195.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    35. Responses to the proposed DSM-V changes. J Sex Med. 2010 Jun; 7(6):1998-2014. Derogatis LR, Laan E, Brauer M, Van Lunsen RHW, Jannini EA, Davis SR, Fabre L, Smith LC, Basson R, Guay AT, Rubio-Aurioles E, Goldstein A, Pukall C, Kellogg S, Burrows L, Morrison P, Krychman M, Goldstein SW, Goldstein I. PMID: 20929516.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    36. Human prostate sphere-forming cells represent a subset of basal epithelial cells capable of glandular regeneration in vivo. Prostate. 2010 Apr 01; 70(5):491-501. Garraway IP, Sun W, Tran CP, Perner S, Zhang B, Goldstein AS, Hahm SA, Haider M, Head CS, Reiter RE, Rubin MA, Witte ON. PMID: 19938015; PMCID: PMC2885946.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansCells
    37. Isolation, cultivation and characterization of adult murine prostate stem cells. Nat Protoc. 2010 Apr; 5(4):702-13. Lukacs RU, Goldstein AS, Lawson DA, Cheng D, Witte ON. PMID: 20360765; PMCID: PMC2943378.
      View in: PubMed   Mentions: 98     Fields:    Translation:AnimalsCells
    38. ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate cells. Proc Natl Acad Sci U S A. 2009 Jul 28; 106(30):12465-70. Zong Y, Xin L, Goldstein AS, Lawson DA, Teitell MA, Witte ON. PMID: 19592505; PMCID: PMC2708977.
      View in: PubMed   Mentions: 116     Fields:    Translation:AnimalsCells
    39. Trop2 identifies a subpopulation of murine and human prostate basal cells with stem cell characteristics. Proc Natl Acad Sci U S A. 2008 Dec 30; 105(52):20882-7. Goldstein AS, Lawson DA, Cheng D, Sun W, Garraway IP, Witte ON. PMID: 19088204; PMCID: PMC2603432.
      View in: PubMed   Mentions: 192     Fields:    Translation:HumansAnimalsCells
    40. Epithelial stem cells of the prostate and their role in cancer progression. Cold Spring Harb Symp Quant Biol. 2008; 73:491-502. Lukacs RU, Lawson DA, Xin L, Zong Y, Garraway I, Goldstein AS, Memarzadeh S, Witte ON. PMID: 19022743.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    Andrew's Networks
    Concepts (180)
    Derived automatically from this person's publications.
    _
    Co-Authors (18)
    People in Profiles who have published with this person.
    _
    Similar People (60)
    People who share similar concepts with this person.
    _
    Same Department
    Search Department
    _