Paul Christopher Boutros

Title(s)Act/interim Assoc Dean, Deans Office-School Of Medicin
SchoolMedicine
ORCID ORCID Icon0000-0003-0553-7520 Additional info
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    Other Positions
    Title(s)Professor, Human Genetics

    Title(s)Professor, Urology


    Collapse Biography 
    Collapse Education and Training
    University of Waterloo , CanadaB.Sc.2004Chemistry
    University of Toronto , CanadaPhD2008Medical Biophysics
    University of Toronto , CanadaExecutive MBA2016Business Administration
    Institute of Genetics, Canadian Institutes of Health Research, Canada2017Sex and Gender in Biomedical Research Workshop
    Howard Hughes Medical Institute, USA2022Mentorship Skills Development Course
    Rotman School of Management, University of Toronto, Canada2017Rotman-UHN Leadership Training Program
    University of California, Los Angeles, USA2021Advanced Faculty Mentoring Training
    Collapse Awards and Honors
    University of California, Los Angeles2023Excellence in Postdoctoral Mentoring Award
    University of California, Los Angeles2023Outstanding Mentorship Award, BIG Summer Research Program
    Journal of the National Cancer Institute2019  - 2020Top 25 Peer Reviewer
    Canadian Cancer Society20182018 Bernard and Francine Dorval Prize
    European Urology2018Reviewer of the Month
    Rotman School of Management, University of Toronto2016Dean’s List & Bregman’s Scholar
    Faculty of Medicine Graduate Teaching Award, University of Toronto2016Early Career Excellence in Graduate Teaching and Mentorship
    University of Waterloo, Faculty of Science2015Young Alumni Award
    DREAM AML Prognosis Challenge Sub-Challenge 2: Remission Duration20141st Place
    DREAM AML Prognosis Challenge Sub-Challenge 3: Overall Survival Time20141st Place
    Prostate Cancer Canada2013Travel Award
    Prostate Cancer Canada2012Collaboration Exploration and Development Award
    Canadian Cancer Society Research Institute2010CCSRI Junior Investigator Grant Panel Travel Award
    The 17th International Conference on Intelligent Systems for Molecular Biology2009Travel Award
    The 11th International Meeting of the Microarray and Gene Expression Data Society2008Travel Award (declined)
    Department of Medical Biophysics Harold Johns Memorial Prize2008First Place Oral Presentation
    BioConductor Workshop 20082008Travel Award
    International Society for Computational Biology Student Council2008Travel Award
    National Cancer Institute of Canada2007Travel Award
    Canadian Cancer Society2007Travel Award
    BioVision.Nxt2007Fellow
    UHN Research Day 20062006Abstract Winner
    Canadian Institutes for Health Research / BioContact-Québec2006First Place CIHR Next Generation Award
    Canadian Institutes for Health Research / BioContact-Québec2006Travel Award
    Invitrogen Canada, Inc.2006Invitrogen Canada Young Investigator Silver Award
    Natural Sciences and Engineering Research Council2006  - 2009CGS Postgraduate Fellowship
    Excellence in Radiation Research for the 21st Century CIHR STIHR2006  - 2008CIHR Strategic Training Fellowship Alumni Award
    The Government of Ontario2006  - 2007Ontario Graduate Scholarship (declined)
    25th International Symposium on Halogenated Environmental Organic Pollutants and POPs2005Student Presenter Award
    CIHR EIRR21st Research Day2005Best Presentation Award
    Excellence in Radiation Research for the 21st Century CIHR STIHR2005  - 2007CIHR Strategic Training Fellowship (2007 declined)
    Institute for Robotics and Intelligent Systems2004PRECARN Fellowship
    15th International Symposium on Microsomes and Drug Oxidations; Mainz, Germany2004First Prize, Poster Presentations
    National Undergraduate Chemistry Conference2003First Place, Overall
    National Undergraduate Chemistry Conference2003Travel Award
    Southwestern Ontario Undergraduate Conference2003Second Place, Biochemistry Presentation
    University of Waterloo, Faculty of Science2002Dean’s Honour List
    Dow Canada Environmental Chemistry2001Work-Term Report Award

    Collapse Overview 
    Collapse Overview
    Paul Boutros, Ph.D., M.B.A., is a cancer data scientist and professor in the departments of human genetics and urology at the David Geffen School of Medicine at UCLA. He currently serves as director of the UCLA Jonsson Comprehensive Cancer Center’s Cancer Data Science program, Associate Director of cancer informatics at the UCLA Institute for Precision Health, and is a member of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research.

    The research in Boutros’ laboratory lies at the intersection of clinical, molecular and imaging data. He focuses on how these diverse pieces of information can be linked to personalize therapy for cancer patients. By applying techniques from modern data science strategies, particularly machine-learning, he creates biomarkers to help ensure therapies are selected that maximize cure and minimize morbidities. His work sometimes centers on specific tumor types, particularly prostate and sarcoma, but often includes others in conjunction to identify general and tumor-type specific features of cancer. Some of his recent studies focus on how cancers develop differently based on the sex, age or ancestric features of the patient.

    Boutros has published over 300 peer-reviewed papers, and in his leadership roles as professor in the departments of human genetics and urology, he is currently working to support personalizing therapy for cancer by developing novel statistical methodologies. He leads the ICGC-TCGA DREAM Somatic Mutation Calling Challenge that is setting global standards for analyzing cancer genomic data, and drives programs in cancer genomics, data science and biomarker translation.

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The N6-methyladenosine Epitranscriptomic Landscape of Lung Adenocarcinoma. Cancer Discov. 2024 Nov 01; 14(11):2279-2299. Wang S, Zeng Y, Zhu L, Zhang M, Zhou L, Yang W, Luo W, Wang L, Liu Y, Zhu H, Xu X, Su P, Zhang X, Ahmed M, Chen W, Chen M, Chen S, Slobodyanyuk M, Xie Z, Guan J, Zhang W, Khan AA, Sakashita S, Liu N, Pham NA, Boutros PC, Ke Z, Moran MF, Cai Z, Cheng C, Yu J, Tsao MS, He HH. PMID: 38922581; PMCID: PMC11528209.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Upgrading of Grade Group 1 Prostate Cancer at Prostatectomy: Germline Risk Factors in a Prospective Cohort. Cancer Epidemiol Biomarkers Prev. 2024 Nov 01; 33(11):1500-1511. Liss MA, Zeltser N, Zheng Y, Lopez C, Liu M, Patel Y, Yamaguchi TN, Eng SE, Tian M, Semmes OJ, Lin DW, Brooks JD, Wei JT, Klein EA, Tewari AK, Mosquera JM, Khani F, Robinson BD, Aasad M, Troyer DA, Kagan J, Sanda MG, Thompson IM, Boutros PC, Leach RJ. PMID: 39158404; PMCID: PMC11528207.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. iSubGen generates integrative disease subtypes by pairwise similarity assessment. Cell Rep Methods. 2024 Oct 18; 100884. Fox NS, Tian M, Markowitz AL, Haider S, Li CH, Boutros PC. PMID: 39447572.
      View in: PubMed   Mentions:    Fields:    
    4. Case report: dynamic personalized physiological monitoring in lung cancer using wearable data. Front Oncol. 2024; 14:1420888. Bliss JW, Underwood WP, Carlson AM, Scott JM, Daly R, Li BT, Drilon A, Stetson P, Boutros PC, Jones LW. PMID: 39429470; PMCID: PMC11486691.
      View in: PubMed   Mentions:
    5. The landscape of drug sensitivity and resistance in sarcoma. Cell Stem Cell. 2024 Oct 03; 31(10):1524-1542.e4. Al Shihabi A, Tebon PJ, Nguyen HTL, Chantharasamee J, Sartini S, Davarifar A, Jensen AY, Diaz-Infante M, Cox H, Gonzalez AE, Norris S, Sperry J, Nakashima J, Tavanaie N, Winata H, Fitz-Gibbon ST, Yamaguchi TN, Jeong JH, Dry S, Singh AS, Chmielowski B, Crompton JG, Kalbasi AK, Eilber FC, Hornicek F, Bernthal NM, Nelson SD, Boutros PC, Federman NC, Yanagawa J, Soragni A. PMID: 39305899.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Molecular Hallmarks of Prostate-specific Membrane Antigen in Treatment-naïve Prostate Cancer. Eur Urol. 2024 Sep 17. Weiner AB, Agrawal R, Wang NK, Sonni I, Li EV, Arbet J, Zhang JJH, Proudfoot JA, Hong BH, Davicioni E, Kane N, Valle LF, Kishan AU, Pra AD, Ghadjar P, Sweeney CJ, Nickols NG, Karnes RJ, Shen J, Rettig MB, Czernin J, Ross AE, Lee Kiang Chua M, Schaeffer EM, Calais J, Boutros PC, Reiter RE. PMID: 39294048.
      View in: PubMed   Mentions:    Fields:    
    7. moPepGen: Rapid and Comprehensive Identification of Non-canonical Peptides. bioRxiv. 2024 Sep 13. Zhu C, Liu LY, Ha A, Yamaguchi TN, Zhu H, Hugh-White R, Livingstone J, Patel Y, Kislinger T, Boutros PC. PMID: 38585946; PMCID: PMC10996593.
      View in: PubMed   Mentions:
    8. Metapipeline-DNA: A Comprehensive Germline & Somatic Genomics Nextflow Pipeline. bioRxiv. 2024 Sep 07. Patel Y, Zhu C, Yamaguchi TN, Wang NK, Wiltsie N, Gonzalez AE, Winata HK, Zeltser N, Pan Y, Mootor MFE, Sanders T, Kandoth C, Fitz-Gibbon ST, Livingstone J, Liu LY, Carlin B, Holmes A, Oh J, Sahrmann J, Tao S, Eng S, Hugh-White R, Pashminehazar K, Park A, Beshlikyan A, Jordan M, Wu S, Tian M, Arbet J, Neilsen B, Bugh YZ, Kim G, Salmingo J, Zhang W, Haas R, Anand A, Hwang E, Neiman-Golden A, Steinberg P, Zhao W, Anand P, Tsai BL, Boutros PC. PMID: 39282325; PMCID: PMC11398472.
      View in: PubMed   Mentions:
    9. The Proteogenomics of Prostate Cancer Radioresistance. Cancer Res Commun. 2024 Sep 01; 4(9):2463-2479. Haas R, Frame G, Khan S, Neilsen BK, Hong BH, Yeo CPX, Yamaguchi TN, Ong EHW, Zhao W, Carlin B, Yeo ELL, Tan KM, Bugh YZ, Zhu C, Hugh-White R, Livingstone J, Poon DJJ, Chu PL, Patel Y, Tao S, Ignatchenko V, Kurganovs NJ, Higgins GS, Downes MR, Loblaw A, Vesprini D, Kishan AU, Chua MLK, Kislinger T, Boutros PC, Liu SK. PMID: 39166898; PMCID: PMC11411600.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    10. Neoadjuvant Exercise Therapy in Prostate Cancer: A Phase 1, Decentralized Nonrandomized ControlledTrial. JAMA Oncol. 2024 Sep 01; 10(9):1187-1194. Jones LW, Moskowitz CS, Lee CP, Fickera GA, Chun SS, Michalski MG, Stoeckel K, Underwood WP, Lavery JA, Bhanot U, Linkov I, Dang CT, Ehdaie B, Laudone VP, Eastham JA, Collins A, Sheerin PT, Liu LY, Eng SE, Boutros PC. PMID: 39023900; PMCID: PMC11258635.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    11. Divergent Evolution in Bilateral Prostate Cancer: a Case Study. medRxiv. 2024 Aug 23. Haas R, Patel Y, Liu LY, Huang RR, Weiner A, Yamaguchi TN, Agrawal R, Boutros PC, Reiter RE. PMID: 39228741; PMCID: PMC11370525.
      View in: PubMed   Mentions:
    12. Targeting PLOD2 suppresses invasion and metastatic potential in radiorecurrent prostate cancer. BJC Rep. 2024; 2(1):60. Frame G, Leong H, Haas R, Huang X, Wright J, Emmenegger U, Downes M, Boutros PC, Kislinger T, Liu SK. PMID: 39184453; PMCID: PMC11338830.
      View in: PubMed   Mentions:
    13. Best practices to evaluate the impact of biomedical research software-metric collection beyond citations. Bioinformatics. 2024 08 02; 40(8). Afiaz A, Ivanov AA, Chamberlin J, Hanauer D, Savonen CL, Goldman MJ, Morgan M, Reich M, Getka A, Holmes A, Pati S, Knight D, Boutros PC, Bakas S, Caporaso JG, Del Fiol G, Hochheiser H, Haas B, Schloss PD, Eddy JA, Albrecht J, Fedorov A, Waldron L, Hoffman AM, Bradshaw RL, Leek JT, Wright C. PMID: 39067017; PMCID: PMC11297485.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. De-escalation of Monitoring in Active Surveillance for Prostate Cancer: Results from the GAP3 Consortium. Eur Urol Oncol. 2024 Jul 31. Tohi Y, Sahrmann JM, Arbet J, Kato T, Lee LS, Peacock M, Ginsburg K, Pavlovich C, Carroll P, Bangma CH, Sugimoto M, Boutros PC, Global Action Plan Prostate Cancer Active Surveillance (GAP3) Consortium. PMID: 39089946.
      View in: PubMed   Mentions:    Fields:    
    15. Increased frequency of clonal hematopoiesis of indeterminate potential in Bloom syndrome probands and carriers. Haematologica. 2024 Jul 25. Lin I, Wei A, Gebo TA, Boutros PC, Flanagan M, Kucine N, Cunniff C, Arboleda VA, Chang VY. PMID: 39049596.
      View in: PubMed   Mentions:    Fields:    
    16. Transcriptomic Profiling of Primary Prostate Cancers and Nonlocalized Disease on Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography: A Multicenter Retrospective Study. JCO Precis Oncol. 2024 Jul; 8:e2400161. Nikitas J, Subramanian K, Gozal NB, Ricaurte-Fajardo A, Li E, Proudfoot JA, Davicioni E, Marciscano AE, Osborne JR, Barbieri CE, Armstrong WR, Smith CP, Valle LF, Steinberg ML, Boutros PC, Nickols NG, Rettig MB, Reiter R, Weiner AB, Calais J, Czernin J, Ross AE, Kim EH, Nagar H, Kishan AU. PMID: 39013135.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    17. Prostate cancer reshapes the secreted and extracellular vesicle urinary proteomes. Nat Commun. 2024 Jun 13; 15(1):5069. Khoo A, Govindarajan M, Qiu Z, Liu LY, Ignatchenko V, Waas M, Macklin A, Keszei A, Neu S, Main BP, Yang L, Lance RS, Downes MR, Semmes OJ, Vesprini D, Liu SK, Nyalwidhe JO, Boutros PC, Kislinger T. PMID: 38871730; PMCID: PMC11176296.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    18. Crowd-sourced benchmarking of single-sample tumor subclonal reconstruction. Nat Biotechnol. 2024 Jun 11. Salcedo A, Tarabichi M, Buchanan A, Espiritu SMG, Zhang H, Zhu K, Ou Yang TH, Leshchiner I, Anastassiou D, Guan Y, Jang GH, Mootor MFE, Haase K, Deshwar AG, Zou W, Umar I, Dentro S, Wintersinger JA, Chiotti K, Demeulemeester J, Jolly C, Sycza L, Ko M, PCAWG Evolution and Heterogeneity Working Group, SMC-Het Participants, Wedge DC, Morris QD, Ellrott K, Van Loo P, Boutros PC. PMID: 38862616.
      View in: PubMed   Mentions:    Fields:    
    19. A platform for rapid patient-derived cutaneous neurofibroma organoid establishment and screening. Cell Rep Methods. 2024 May 20; 4(5):100772. Nguyen HTL, Kohl E, Bade J, Eng SE, Tosevska A, Al Shihabi A, Tebon PJ, Hong JJ, Dry S, Boutros PC, Panossian A, Gosline SJC, Soragni A. PMID: 38744290; PMCID: PMC11133839.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    20. Comprehensive Prostate Fluid-Based Spectral Libraries for Enhanced Protein Detection in Urine. J Proteome Res. 2024 May 03; 23(5):1768-1778. Ha A, Khoo A, Ignatchenko V, Khan S, Waas M, Vesprini D, Liu SK, Nyalwidhe JO, Semmes OJ, Boutros PC, Kislinger T. PMID: 38580319; PMCID: PMC11077481.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    21. Genomic evolution shapes prostate cancer disease type. Cell Genom. 2024 Mar 13; 4(3):100511. Woodcock DJ, Sahli A, Teslo R, Bhandari V, Gruber AJ, Ziubroniewicz A, Gundem G, Xu Y, Butler A, Anokian E, Pope BJ, Jung CH, Tarabichi M, Dentro SC, Farmery JHR, CRUK ICGC Prostate Group, Van Loo P, Warren AY, Gnanapragasam V, Hamdy FC, Bova GS, Foster CS, Neal DE, Lu YJ, Kote-Jarai Z, Fraser M, Bristow RG, Boutros PC, Costello AJ, Corcoran NM, Hovens CM, Massie CE, Lynch AG, Brewer DS, Eeles RA, Cooper CS, Wedge DC. PMID: 38428419; PMCID: PMC10943594.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. The genomic and evolutionary landscapes of anaplastic thyroid carcinoma. Cell Rep. 2024 Mar 26; 43(3):113826. Zeng PYF, Prokopec SD, Lai SY, Pinto N, Chan-Seng-Yue MA, Clifton-Bligh R, Williams MD, Howlett CJ, Plantinga P, Cecchini MJ, Lam AK, Siddiqui I, Wang J, Sun RX, Watson JD, Korah R, Carling T, Agrawal N, Cipriani N, Ball D, Nelkin B, Rooper LM, Bishop JA, Garnis C, Berean K, Nicolson NG, Weinberger P, Henderson YC, Lalansingh CM, Tian M, Yamaguchi TN, Livingstone J, Salcedo A, Patel K, Vizeacoumar F, Datti A, Xi L, Nikiforov YE, Smallridge R, Copland JA, Marlow LA, Hyrcza MD, Delbridge L, Sidhu S, Sywak M, Robinson B, Fung K, Ghasemi F, Kwan K, MacNeil SD, Mendez A, Palma DA, Khan MI, Shaikh M, Ruicci KM, Wehrli B, Winquist E, Yoo J, Mymryk JS, Rocco JW, Wheeler D, Scherer S, Giordano TJ, Barrett JW, Faquin WC, Gill AJ, Clayman G, Boutros PC, Nichols AC. PMID: 38412093; PMCID: PMC11077417.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    23. Quantifying the seed sensitivity of cancer subclonal reconstruction algorithms. bioRxiv. 2024 Feb 08. Steinberg PL, Liu LY, Neiman-Golden A, Patel Y, Boutros PC. PMID: 38370678; PMCID: PMC10871259.
      View in: PubMed   Mentions:
    24. Increased Frequency of Clonal Hematopoiesis of Indeterminate Potential in Bloom Syndrome Probands and Carriers. medRxiv. 2024 Feb 06. Lin I, Wei A, Gebo TA, Boutros PC, Flanagan M, Kucine N, Cunniff C, Arboleda VA, Chang VY. PMID: 38370823; PMCID: PMC10871368.
      View in: PubMed   Mentions:
    25. PipeVal: light-weight extensible tool for file validation. Bioinformatics. 2024 02 01; 40(2). Patel Y, Beshlikyan A, Jordan M, Kim G, Holmes A, Yamaguchi TN, Boutros PC. PMID: 38341658; PMCID: PMC10893582.
      View in: PubMed   Mentions: 2     Fields:    
    26. NFTest: automated testing of Nextflow pipelines. Bioinformatics. 2024 02 01; 40(2). Patel Y, Zhu C, Yamaguchi TN, Bugh YZ, Tian M, Holmes A, Fitz-Gibbon ST, Boutros PC. PMID: 38341660; PMCID: PMC10881102.
      View in: PubMed   Mentions: 3     Fields:    
    27. Impact of PSMA PET on Prostate Cancer Management. Curr Treat Options Oncol. 2024 02; 25(2):191-205. Weiner AB, Agrawal R, Valle LF, Sonni I, Kishan AU, Rettig MB, Raman SS, Calais J, Boutros PC, Reiter RE. PMID: 38270802; PMCID: PMC11034977.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    28. Glioblastoma evolution and heterogeneity from a 3D whole-tumor perspective. Cell. 2024 01 18; 187(2):446-463.e16. Mathur R, Wang Q, Schupp PG, Nikolic A, Hilz S, Hong C, Grishanina NR, Kwok D, Stevers NO, Jin Q, Youngblood MW, Stasiak LA, Hou Y, Wang J, Yamaguchi TN, Lafontaine M, Shai A, Smirnov IV, Solomon DA, Chang SM, Hervey-Jumper SL, Berger MS, Lupo JM, Okada H, Phillips JJ, Boutros PC, Gallo M, Oldham MC, Yue F, Costello JF. PMID: 38242087; PMCID: PMC10832360.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    29. Association of exercise with pan-cancer incidence and overall survival. Cancer Cell. 2024 02 12; 42(2):169-171. Lavery JA, Boutros PC, Knight D, Tammela T, Moskowitz CS, Jones LW. PMID: 38181796; PMCID: PMC11369973.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    30. Prostate-Specific Antigen Response to Androgen Deprivation Therapy in the Neoadjuvant Setting for High-Risk Prostate Adenocarcinoma (PIRANHA): Pooled Analysis of Two Randomized Clinical Trials. Int J Radiat Oncol Biol Phys. 2024 Jul 01; 119(3):826-831. Nikitas J, Ong WL, Carrier N, Romero T, Millar J, Steinberg ML, Rettig MB, Boutros PC, Reiter R, Nickols NG, Valle L, McGuire SE, Spratt DE, Souhami L, Roy S, Martin JM, Joseph D, Nabid A, Kishan AU. PMID: 38151191.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    31. HPV-negative head and neck cancers with adverse pathological features carry specific molecular changes that are associated with survival. Head Neck. 2024 02; 46(2):353-366. Kim HAJ, Zeng PYF, Cecchini M, Shaikh MH, Laxague F, Deng X, Jarycki L, Ryan SEB, Dawson A, Liu MH, Palma DA, Patel K, Mundi N, Barrett JW, Mymryk JS, Boutros PC, Nichols AC. PMID: 38059331.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    32. Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment. Nat Cell Biol. 2023 Dec; 25(12):1821-1832. Giafaglione JM, Crowell PD, Delcourt AML, Hashimoto T, Ha SM, Atmakuri A, Nunley NM, Dang RMA, Tian M, Diaz JA, Tika E, Payne MC, Burkhart DL, Li D, Navone NM, Corey E, Nelson PS, Lin NYC, Blanpain C, Ellis L, Boutros PC, Goldstein AS. PMID: 38049604; PMCID: PMC10709144.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    33. MYC is a regulator of androgen receptor inhibition-induced metabolic requirements in prostate cancer. Cell Rep. 2023 10 31; 42(10):113221. Crowell PD, Giafaglione JM, Jones AE, Nunley NM, Hashimoto T, Delcourt AML, Petcherski A, Agrawal R, Bernard MJ, Diaz JA, Heering KY, Huang RR, Low JY, Matulionis N, Navone NM, Ye H, Zoubeidi A, Christofk HR, Rettig MB, Reiter RE, Haffner MC, Boutros PC, Shirihai OS, Divakaruni AS, Goldstein AS. PMID: 37815914.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    34. Loss of LRP1B expression drives acquired chemo and radio-resistance in HPV-positive head and neck cancer. Oral Oncol. 2023 11; 146:106580. Shaikh MH, Dawson A, Prokopec SD, Barrett JW, Y F Zeng P, Khan MI, Ryan SEB, Cecchini M, Palma DA, Mymryk JS, Boutros PC, Nichols AC. PMID: 37778229.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    35. Pan-Cancer Analysis of Postdiagnosis Exercise and Mortality. J Clin Oncol. 2023 Nov 10; 41(32):4982-4992. Lavery JA, Boutros PC, Scott JM, Tammela T, Moskowitz CS, Jones LW. PMID: 37651670.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    36. The landscape of drug sensitivity and resistance in sarcoma. bioRxiv. 2023 Aug 08. Al Shihabi A, Tebon PJ, Nguyen HTL, Chantharasamee J, Sartini S, Davarifar A, Jensen AY, Diaz-Infante M, Cox H, Gonzalez AE, Swearingen S, Tavanaie N, Dry S, Singh A, Chmielowski B, Crompton JG, Kalbasi A, Eilber FC, Hornicek F, Bernthal N, Nelson SD, Boutros PC, Federman N, Yanagawa J, Soragni A. PMID: 37292676; PMCID: PMC10245988.
      View in: PubMed   Mentions: 1  
    37. Prostate Cancer Reshapes the Secreted and Extracellular Vesicle Urinary Proteomes. bioRxiv. 2023 Jul 25. Khoo A, Govindarajan M, Qiu Z, Liu LY, Ignatchenko V, Waas M, Macklin A, Keszei A, Main BP, Yang L, Lance RS, Downes MR, Semmes OJ, Vesprini D, Liu SK, Nyalwidhe JO, Boutros PC, Kislinger T. PMID: 37546794; PMCID: PMC10402038.
      View in: PubMed   Mentions:
    38. Correction: Increased mRNA expression of CDKN2A is a transcriptomic marker of clinically aggressive meningiomas. Acta Neuropathol. 2023 Jul; 146(1):171-172. Wang JZ, Patil V, Liu J, Dogan H, Tabatabai G, Yefet LS, Behling F, Hoffman E, Bunda S, Yakubov R, Kaloti R, Brandner S, Gao A, Cohen-Gadol A, Barnholtz-Sloan J, Skardelly M, Tatagiba M, Raleigh DR, Sahm F, Boutros PC, Aldape K, International Consortium on Meningiomas (ICOM), Nassiri F, Zadeh G. PMID: 37171636; PMCID: PMC10261159.
      View in: PubMed   Mentions:    Fields:    
    39. Drug screening at single-organoid resolution via bioprinting and interferometry. Nat Commun. 2023 06 06; 14(1):3168. Tebon PJ, Wang B, Markowitz AL, Davarifar A, Tsai BL, Krawczuk P, Gonzalez AE, Sartini S, Murray GF, Nguyen HTL, Tavanaie N, Nguyen TL, Boutros PC, Teitell MA, Soragni A. PMID: 37280220; PMCID: PMC10244450.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    40. Evaluation of software impact designed for biomedical research: Are we measuring what's meaningful? ArXiv. 2023 Jun 05. Afiaz A, Ivanov AA, Chamberlin J, Hanauer D, Savonen CL, Goldman MJ, Morgan M, Reich M, Getka A, Holmes A, Pati S, Knight D, Boutros PC, Bakas S, Caporaso JG, Del Fiol G, Hochheiser H, Haas B, Schloss PD, Eddy JA, Albrecht J, Fedorov A, Waldron L, Hoffman AM, Bradshaw RL, Leek JT, Wright C. PMID: 37332562; PMCID: PMC10274942.
      View in: PubMed   Mentions:
    41. Serrate RNA Effector Molecule (SRRT) Is Associated with Prostate Cancer Progression and Is a Predictor of Poor Prognosis in Lethal Prostate Cancer. Cancers (Basel). 2023 May 22; 15(10). Gamallat Y, Choudhry M, Li Q, Rokne JG, Alhajj R, Abdelsalam R, Ghosh S, Arbet J, Boutros PC, Bismar TA. PMID: 37345203; PMCID: PMC10216025.
      View in: PubMed   Mentions:
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    47. Single-Cell Analysis in Lung Adenocarcinoma Implicates RNA Editing in Cancer Innate Immunity and Patient Prognosis. Cancer Res. 2023 02 03; 83(3):374-385. Chan TW, Dodson JP, Arbet J, Boutros PC, Xiao X. PMID: 36449563; PMCID: PMC9898195.
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    49. Minimal information for reporting a genomics experiment. Blood. 2022 12 15; 140(24):2549-2555. Dreval K, Boutros PC, Morin RD. PMID: 36219881; PMCID: PMC10653092.
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    50. Author Correction: Divergent mutational processes distinguish hypoxic and normoxic tumours. Nat Commun. 2022 Dec 08; 13(1):7569. Bhandari V, Li CH, Bristow RG, Boutros PC, PCAWG Consortium. PMID: 36481612; PMCID: PMC9731962.
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    54. Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative. PLoS Genet. 2022 11; 18(11):e1010367. Butler-Laporte G, Povysil G, Kosmicki JA, Cirulli ET, Drivas T, Furini S, Saad C, Schmidt A, Olszewski P, Korotko U, Quinodoz M, Çelik E, Kundu K, Walter K, Jung J, Stockwell AD, Sloofman LG, Jordan DM, Thompson RC, Del Valle D, Simons N, Cheng E, Sebra R, Schadt EE, Kim-Schulze S, Gnjatic S, Merad M, Buxbaum JD, Beckmann ND, Charney AW, Przychodzen B, Chang T, Pottinger TD, Shang N, Brand F, Fava F, Mari F, Chwialkowska K, Niemira M, Pula S, Baillie JK, Stuckey A, Salas A, Bello X, Pardo-Seco J, Gómez-Carballa A, Rivero-Calle I, Martinón-Torres F, Ganna A, Karczewski KJ, Veerapen K, Bourgey M, Bourque G, Eveleigh RJ, Forgetta V, Morrison D, Langlais D, Lathrop M, Mooser V, Nakanishi T, Frithiof R, Hultström M, Lipcsey M, Marincevic-Zuniga Y, Nordlund J, Schiabor Barrett KM, Lee W, Bolze A, White S, Riffle S, Tanudjaja F, Sandoval E, Neveux I, Dabe S, Casadei N, Motameny S, Alaamery M, Massadeh S, Aljawini N, Almutairi MS, Arabi YM, Alqahtani SA, Al Harthi FS, Almutairi A, Alqubaishi F, Alotaibi S, Binowayn A, Alsolm EA, El Bardisy H, Fawzy M, Cai F, Soranzo N, Butterworth A, COVID-19 Host Genetics Initiative, DeCOI Host Genetics Group, GEN-COVID Multicenter Study (Italy), Mount Sinai Clinical Intelligence Center, GEN-COVID consortium (Spain), GenOMICC Consortium, Japan COVID-19 Task Force, Regeneron Genetics Center, Geschwind DH, Arteaga S, Stephens A, Butte MJ, Boutros PC, Yamaguchi TN, Tao S, Eng S, Sanders T, Tung PJ, Broudy ME, Pan Y, Gonzalez A, Chavan N, Johnson R, Pasaniuc B, Yaspan B, Smieszek S, Rivolta C, Bibert S, Bochud PY, Dabrowski M, Zawadzki P, Sypniewski M, Kaja E, Chariyavilaskul P, Nilaratanakul V, Hirankarn N, Shotelersuk V, Pongpanich M, Phokaew C, Chetruengchai W, Tokunaga K, Sugiyama M, Kawai Y, Hasegawa T, Naito T, Namkoong H, Edahiro R, Kimura A, Ogawa S, Kanai T, Fukunaga K, Okada Y, Imoto S, Miyano S, Mangul S, Abedalthagafi MS, Zeberg H, Grzymski JJ, Washington NL, Ossowski S, Ludwig KU, Schulte EC, Riess O, Moniuszko M, Kwasniewski M, Mbarek H, Ismail SI, Verma A, Goldstein DB, Kiryluk K, Renieri A, Ferreira MAR, Richards JB. PMID: 36327219; PMCID: PMC9632827.
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    55. The 5-Hydroxymethylcytosine Landscape of Prostate Cancer. Cancer Res. 2022 11 02; 82(21):3888-3902. Sjöström M, Zhao SG, Levy S, Zhang M, Ning Y, Shrestha R, Lundberg A, Herberts C, Foye A, Aggarwal R, Hua JT, Li H, Bergamaschi A, Maurice-Dror C, Maheshwari A, Chen S, Ng SWS, Ye W, Petricca J, Fraser M, Chesner L, Perry MD, Moreno-Rodriguez T, Chen WS, Alumkal JJ, Chou J, Morgans AK, Beer TM, Thomas GV, Gleave M, Lloyd P, Phillips T, McCarthy E, Haffner MC, Zoubeidi A, Annala M, Reiter RE, Rettig MB, Witte ON, Fong L, Bose R, Huang FW, Luo J, Bjartell A, Lang JM, Mahajan NP, Lara PN, Evans CP, Tran PT, Posadas EM, He C, Cui XL, Huang J, Zwart W, Gilbert LA, Maher CA, Boutros PC, Chi KN, Ashworth A, Small EJ, He HH, Wyatt AW, Quigley DA, Feng FY. PMID: 36251389; PMCID: PMC9627125.
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    56. The proteomic landscape of glioblastoma recurrence reveals novel and targetable immunoregulatory drivers. Acta Neuropathol. 2022 12; 144(6):1127-1142. Tatari N, Khan S, Livingstone J, Zhai K, Mckenna D, Ignatchenko V, Chokshi C, Gwynne WD, Singh M, Revill S, Mikolajewicz N, Zhu C, Chan J, Hawkins C, Lu JQ, Provias JP, Ask K, Morrissy S, Brown S, Weiss T, Weller M, Han H, Greenspoon JN, Moffat J, Venugopal C, Boutros PC, Singh SK, Kislinger T. PMID: 36178522; PMCID: PMC10187978.
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    57. External Beam Radiation Therapy With or Without Brachytherapy Boost in Men With Very-High-Risk Prostate Cancer: A Large Multicenter International Consortium Analysis. Int J Radiat Oncol Biol Phys. 2023 03 01; 115(3):645-653. Patel SA, Ma TM, Wong JK, Stish BJ, Dess RT, Pilar A, Reddy C, Wedde TB, Lilleby WA, Fiano R, Merrick GS, Stock RG, Demanes DJ, Moran BJ, Tran PT, Krauss DJ, Abu-Isa EI, Pisansky TM, Choo CR, Song DY, Greco S, Deville C, DeWeese TL, Tilki D, Ciezki JP, Karnes RJ, Nickols NG, Rettig MB, Feng FY, Berlin A, Tward JD, Davis BJ, Reiter RE, Boutros PC, Romero T, Horwitz EM, Tendulkar RD, Steinberg ML, Spratt DE, Xiang M, Kishan AU. PMID: 36179990.
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    58. Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapy. Oncotarget. 2022; 13:1054-1067. Ueno D, Vasquez JC, Sule A, Liang J, van Doorn J, Sundaram R, Friedman S, Caliliw R, Ohtake S, Bao X, Li J, Ye H, Boyd K, Huang RR, Dodson J, Boutros P, Bindra RS, Shuch B. PMID: 36128328; PMCID: PMC9477221.
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    59. Perish and publish: Dynamics of biomedical publications by deceased authors. PLoS One. 2022; 17(9):e0273783. Jung CH, Boutros PC, Park DJ, Corcoran NM, Pope BJ, Hovens CM. PMID: 36103484; PMCID: PMC9473445.
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    60. Prospective comparison of restriction spectrum imaging and non-invasive biomarkers to predict upgrading on active surveillance prostate biopsy. Prostate Cancer Prostatic Dis. 2024 Mar; 27(1):65-72. Eng SE, Basasie B, Lam A, John Semmes O, Troyer DA, Clarke GD, Sunnapwar AG, Leach RJ, Johnson-Pais TL, Sokoll LJ, Chan DW, Tosoian JJ, Siddiqui J, Chinnaiyan AM, Thompson IM, Boutros PC, Liss MA. PMID: 36097168.
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    63. Estimation of tumor cell total mRNA expression in 15 cancer types predicts disease progression. Nat Biotechnol. 2022 11; 40(11):1624-1633. Cao S, Wang JR, Ji S, Yang P, Dai Y, Guo S, Montierth MD, Shen JP, Zhao X, Chen J, Lee JJ, Guerrero PA, Spetsieris N, Engedal N, Taavitsainen S, Yu K, Livingstone J, Bhandari V, Hubert SM, Daw NC, Futreal PA, Efstathiou E, Lim B, Viale A, Zhang J, Nykter M, Czerniak BA, Brown PH, Swanton C, Msaouel P, Maitra A, Kopetz S, Campbell P, Speed TP, Boutros PC, Zhu H, Urbanucci A, Demeulemeester J, Van Loo P, Wang W. PMID: 35697807; PMCID: PMC9646498.
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    64. Impact of Exercise on Susceptibility and Severity of COVID-19 in Patients with Cancer: A Retrospective Study. Cancer Epidemiol Biomarkers Prev. 2022 05 04; 31(5):1036-1042. Bliss JW, Lavery JA, Underwood WP, Chun SS, Fickera GA, Lee CP, Corcoran S, Maloy MA, Polubriaginof FC, Kelly DW, Scott JM, Boutros PC, Moskowitz CS, Jones LW. PMID: 35506245; PMCID: PMC9135110.
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    66. Virally programmed extracellular vesicles sensitize cancer cells to oncolytic virus and small molecule therapy. Nat Commun. 2022 04 07; 13(1):1898. Wedge ME, Jennings VA, Crupi MJF, Poutou J, Jamieson T, Pelin A, Pugliese G, de Souza CT, Petryk J, Laight BJ, Boileau M, Taha Z, Alluqmani N, McKay HE, Pikor L, Khan ST, Azad T, Rezaei R, Austin B, He X, Mansfield D, Rose E, Brown EEF, Crawford N, Alkayyal A, Surendran A, Singaravelu R, Roy DG, Migneco G, McSweeney B, Cottee ML, Jacobus EJ, Keller BA, Yamaguchi TN, Boutros PC, Geoffrion M, Rayner KJ, Chatterjee A, Auer RC, Diallo JS, Gibbings D, tenOever BR, Melcher A, Bell JC, Ilkow CS. PMID: 35393414; PMCID: PMC8990073.
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    68. Data-driven identification of inherent features of eukaryotic stress-responsive genes. NAR Genom Bioinform. 2022 Mar; 4(1):lqac018. Latorre P, Böttcher R, Nadal-Ribelles M, Li CH, Solé C, Martínez-Cebrián G, Boutros PC, Posas F, de Nadal E. PMID: 35265837; PMCID: PMC8900196.
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    70. Interplay Between Duration of Androgen Deprivation Therapy and External Beam Radiotherapy With or Without a Brachytherapy Boost for Optimal Treatment of High-risk Prostate Cancer: A Patient-Level Data Analysis of 3 Cohorts. JAMA Oncol. 2022 Mar 01; 8(3):e216871. Kishan AU, Steigler A, Denham JW, Zapatero A, Guerrero A, Joseph D, Maldonado X, Wong JK, Stish BJ, Dess RT, Pilar A, Reddy C, Wedde TB, Lilleby WA, Fiano R, Merrick GS, Stock RG, Demanes DJ, Moran BJ, Tran PT, Martin S, Martinez-Monge R, Krauss DJ, Abu-Isa EI, Pisansky TM, Choo CR, Song DY, Greco S, Deville C, McNutt T, DeWeese TL, Ross AE, Ciezki JP, Tilki D, Karnes RJ, Tosoian JJ, Nickols NG, Bhat P, Shabsovich D, Juarez JE, Jiang T, Ma TM, Xiang M, Philipson R, Chang A, Kupelian PA, Rettig MB, Feng FY, Berlin A, Tward JD, Davis BJ, Reiter RE, Steinberg ML, Elashoff D, Boutros PC, Horwitz EM, Tendulkar RD, Spratt DE, Romero T. PMID: 35050303; PMCID: PMC8778608.
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    71. Introduction and expression of PIK3CAE545K in a papillary thyroid cancer BRAFV600E cell line leads to a dedifferentiated aggressive phenotype. J Otolaryngol Head Neck Surg. 2022 Feb 22; 51(1):7. Pinto N, Ruicci KM, Khan MI, Shaikh MH, Zeng YFP, Yoo J, Fung K, MacNeil SD, Mendez A, Mymryk JS, Barrett JW, Boutros PC, Nichols AC. PMID: 35193694; PMCID: PMC8862267.
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    72. Tumor molecular differences associated with outcome disparities of Black patients with head and neck cancer. Head Neck. 2022 05; 44(5):1124-1135. Kim HAJ, Zeng PYF, Sorgini A, Shaikh MH, Khan H, MacNeil D, Khan MI, Mendez A, Yoo J, Fung K, Lang P, Palma DA, Mymryk JS, Barrett JW, Patel KB, Boutros PC, Nichols AC. PMID: 35187756; PMCID: PMC9047510.
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    73. Optimization of small extracellular vesicle isolation from expressed prostatic secretions in urine for in-depth proteomic analysis. J Extracell Vesicles. 2022 02; 11(2):e12184. Correll VL, Otto JJ, Risi CM, Main BP, Boutros PC, Kislinger T, Galkin VE, Nyalwidhe JO, Semmes OJ, Yang L. PMID: 35119778; PMCID: PMC8815402.
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    74. Age influences on the molecular presentation of tumours. Nat Commun. 2022 01 11; 13(1):208. Li CH, Haider S, Boutros PC. PMID: 35017538; PMCID: PMC8752853.
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    75. HLA-A∗02:01 restricted T cell receptors against the highly conserved SARS-CoV-2 polymerase cross-react with human coronaviruses. Cell Rep. 2021 12 28; 37(13):110167. Nesterenko PA, McLaughlin J, Tsai BL, Burton Sojo G, Cheng D, Zhao D, Mao Z, Bangayan NJ, Obusan MB, Su Y, Ng RH, Chour W, Xie J, Li YR, Lee D, Noguchi M, Carmona C, Phillips JW, Kim JT, Yang L, Heath JR, Boutros PC, Witte ON. PMID: 34919800; PMCID: PMC8660260.
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    76. Comparison of Response to Definitive Radiotherapy for Localized Prostate Cancer in Black and White Men: A Meta-analysis. JAMA Netw Open. 2021 12 01; 4(12):e2139769. Ma TM, Romero T, Nickols NG, Rettig MB, Garraway IP, Roach M, Michalski JM, Pisansky TM, Lee WR, Jones CU, Rosenthal SA, Wang C, Hartman H, Nguyen PL, Feng FY, Boutros PC, Saigal C, Chamie K, Jackson WC, Morgan TM, Mehra R, Salami SS, Vince R, Schaeffer EM, Mahal BA, Dess RT, Steinberg ML, Elashoff D, Sandler HM, Spratt DE, Kishan AU. PMID: 34964855; PMCID: PMC8717118.
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    77. Performance of a Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography-Derived Risk-Stratification Tool for High-risk and Very High-risk Prostate Cancer. JAMA Netw Open. 2021 12 01; 4(12):e2138550. Xiang M, Ma TM, Savjani R, Pollom EL, Karnes RJ, Grogan T, Wong JK, Motterle G, Tosoian JJ, Trock BJ, Klein EA, Stish BJ, Dess RT, Spratt DE, Pilar A, Reddy C, Levin-Epstein R, Wedde TB, Lilleby WA, Fiano R, Merrick GS, Stock RG, Demanes DJ, Moran BJ, Huland H, Tran PT, Martin S, Martinez-Monge R, Krauss DJ, Abu-Isa EI, Alam R, Schwen Z, Pisansky TM, Choo CR, Song DY, Greco S, Deville C, McNutt T, DeWeese TL, Ross AE, Ciezki JP, Boutros PC, Nickols NG, Bhat P, Shabsovich D, Juarez JE, Chong N, Kupelian PA, Rettig MB, Zaorsky NG, Berlin A, Tward JD, Davis BJ, Reiter RE, Steinberg ML, Elashoff D, Horwitz EM, Tendulkar RD, Tilki D, Czernin J, Gafita A, Romero T, Calais J, Kishan AU. PMID: 34902034; PMCID: PMC8669522.
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    78. The telomere length landscape of prostate cancer. Nat Commun. 2021 11 25; 12(1):6893. Livingstone J, Shiah YJ, Yamaguchi TN, Heisler LE, Huang V, Lesurf R, Gebo T, Carlin B, Eng S, Drysdale E, Green J, van der Kwast T, Bristow RG, Fraser M, Boutros PC. PMID: 34824250; PMCID: PMC8617305.
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    79. A Canadian Study of Cisplatin Metabolomics and Nephrotoxicity (ACCENT): A Clinical Research Protocol. Can J Kidney Health Dis. 2021; 8:20543581211057708. Jain A, Huang R, Lee J, Jawa N, Lim YJ, Guron M, Abish S, Boutros PC, Brudno M, Carleton B, Cuvelier GDE, Gunaratnam L, Ho C, Adeli K, Kuruvilla S, Lajoie G, Liu G, Nathan PC, Rod Rassekh S, Rieder M, Waikar SS, Welch SA, Weir MA, Winquist E, Wishart DS, Zorzi AP, Blydt-Hansen T, Zappitelli M, Urquhart B. PMID: 34820133; PMCID: PMC8606978.
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    225. Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories. Nat Commun. 2017 01 09; 8:13671. Taylor RA, Fraser M, Livingstone J, Espiritu SM, Thorne H, Huang V, Lo W, Shiah YJ, Yamaguchi TN, Sliwinski A, Horsburgh S, Meng A, Heisler LE, Yu N, Yousif F, Papargiris M, Lawrence MG, Timms L, Murphy DG, Frydenberg M, Hopkins JF, Bolton D, Clouston D, McPherson JD, van der Kwast T, Boutros PC, Risbridger GP, Bristow RG. PMID: 28067867; PMCID: PMC5227331.
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    226. A bedr way of genomic interval processing. Source Code Biol Med. 2016; 11:14. Haider S, Waggott D, Lalonde E, Fung C, Liu FF, Boutros PC. PMID: 27999613; PMCID: PMC5157088.
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    228. novoBreak: local assembly for breakpoint detection in cancer genomes. Nat Methods. 2017 01; 14(1):65-67. Chong Z, Ruan J, Gao M, Zhou W, Chen T, Fan X, Ding L, Lee AY, Boutros P, Chen J, Chen K. PMID: 27892959; PMCID: PMC5199621.
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    229. Molecular heterogeneity of non-small cell lung carcinoma patient-derived xenografts closely reflect their primary tumors. Int J Cancer. 2017 Feb 01; 140(3):662-673. Wang D, Pham NA, Tong J, Sakashita S, Allo G, Kim L, Yanagawa N, Raghavan V, Wei Y, To C, Trinh QM, Starmans MH, Chan-Seng-Yue MA, Chadwick D, Li L, Zhu CQ, Liu N, Li M, Lee S, Ignatchenko V, Strumpf D, Taylor P, Moghal N, Liu G, Boutros PC, Kislinger T, Pintilie M, Jurisica I, Shepherd FA, McPherson JD, Muthuswamy L, Moran MF, Tsao MS. PMID: 27750381.
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    230. Translating a Prognostic DNA Genomic Classifier into the Clinic: Retrospective Validation in 563 Localized Prostate Tumors. Eur Urol. 2017 07; 72(1):22-31. Lalonde E, Alkallas R, Chua MLK, Fraser M, Haider S, Meng A, Zheng J, Yao CQ, Picard V, Orain M, Hovington H, Murgic J, Berlin A, Lacombe L, Bergeron A, Fradet Y, Têtu B, Lindberg J, Egevad L, Grönberg H, Ross-Adams H, Lamb AD, Halim S, Dunning MJ, Neal DE, Pintilie M, van der Kwast T, Bristow RG, Boutros PC. PMID: 27815082.
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    231. A discrete cluster of urinary biomarkers discriminates between active systemic lupus erythematosus patients with and without glomerulonephritis. Arthritis Res Ther. 2016 10 04; 18(1):218. Landolt-Marticorena C, Prokopec SD, Morrison S, Noamani B, Bonilla D, Reich H, Scholey J, Avila-Casado C, Fortin PR, Boutros PC, Wither J. PMID: 27716443; PMCID: PMC5050957.
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    232. VennDiagramWeb: a web application for the generation of highly customizable Venn and Euler diagrams. BMC Bioinformatics. 2016 Oct 03; 17(1):401. Lam F, Lalansingh CM, Babaran HE, Wang Z, Prokopec SD, Fox NS, Boutros PC. PMID: 27716034; PMCID: PMC5048655.
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    233. Nanocall: an open source basecaller for Oxford Nanopore sequencing data. Bioinformatics. 2017 01 01; 33(1):49-55. David M, Dursi LJ, Yao D, Boutros PC, Simpson JT. PMID: 27614348; PMCID: PMC5408768.
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    234. The parameter sensitivity of random forests. BMC Bioinformatics. 2016 Sep 01; 17(1):331. Huang BF, Boutros PC. PMID: 27586051; PMCID: PMC5009551.
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    235. Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer. Nat Genet. 2016 10; 48(10):1142-50. Guo H, Ahmed M, Zhang F, Yao CQ, Li S, Liang Y, Hua J, Soares F, Sun Y, Langstein J, Li Y, Poon C, Bailey SD, Desai K, Fei T, Li Q, Sendorek DH, Fraser M, Prensner JR, Pugh TJ, Pomerantz M, Bristow RG, Lupien M, Feng FY, Boutros PC, Freedman ML, Walsh MJ, He HH. PMID: 27526323.
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    236. BAMQL: a query language for extracting reads from BAM files. BMC Bioinformatics. 2016 Aug 11; 17:305. Masella AP, Lalansingh CM, Sivasundaram P, Fraser M, Bristow RG, Boutros PC. PMID: 27516195; PMCID: PMC4982315.
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    237. A four gene signature of chromosome instability (CIN4) predicts for benefit from taxanes in the NCIC-CTG MA21 clinical trial. Oncotarget. 2016 Aug 02; 7(31):49099-49106. Spears M, Lyttle N, D'Costa A, Chen BE, Yao CQ, Boutros PC, Burnell M, Levine MN, O'Brien P, Shepherd L, Bartlett JM. PMID: 27056899; PMCID: PMC5226493.
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    238. Targeted proteomics identifies liquid-biopsy signatures for extracapsular prostate cancer. Nat Commun. 2016 06 28; 7:11906. Kim Y, Jeon J, Mejia S, Yao CQ, Ignatchenko V, Nyalwidhe JO, Gramolini AO, Lance RS, Troyer DA, Drake RR, Boutros PC, Semmes OJ, Kislinger T. PMID: 27350604; PMCID: PMC4931234.
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    239. A Crowdsourcing Approach to Developing and Assessing Prediction Algorithms for AML Prognosis. PLoS Comput Biol. 2016 06; 12(6):e1004890. Noren DP, Long BL, Norel R, Rrhissorrakrai K, Hess K, Hu CW, Bisberg AJ, Schultz A, Engquist E, Liu L, Lin X, Chen GM, Xie H, Hunter GA, Boutros PC, Stepanov O, DREAM 9 AML-OPC Consortium, Norman T, Friend SH, Stolovitzky G, Kornblau S, Qutub AA. PMID: 27351836; PMCID: PMC4924788.
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    240. Log::ProgramInfo: A Perl module to collect and log data for bioinformatics pipelines. Source Code Biol Med. 2016; 11:9. Macdonald JM, Boutros PC. PMID: 27347003; PMCID: PMC4919834.
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    241. Comparing continuous and discrete analyses of breast cancer survival information. Genomics. 2016 08; 108(2):78-83. Bhandari V, Boutros PC. PMID: 27311755.
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    242. MYC interaction with the tumor suppressive SWI/SNF complex member INI1 regulates transcription and cellular transformation. Cell Cycle. 2016 07 02; 15(13):1693-705. Stojanova A, Tu WB, Ponzielli R, Kotlyar M, Chan PK, Boutros PC, Khosravi F, Jurisica I, Raught B, Penn LZ. PMID: 27267444; PMCID: PMC4957596.
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    243. Current and Evolving Methods to Visualize Biological Data in Cancer Research. J Natl Cancer Inst. 2016 08; 108(8). Chia PL, Gedye C, Boutros PC, Wheatley-Price P, John T. PMID: 27245079; PMCID: PMC5017943.
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    244. A genome-wide association study of non-HPV-related head and neck squamous cell carcinoma identifies prognostic genetic sequence variants in the MAP-kinase and hormone pathways. Cancer Epidemiol. 2016 06; 42:173-80. Azad AK, Bairati I, Qiu X, Girgis H, Cheng L, Waggott D, Cheng D, Mirshams M, Ho J, Fortin A, Vigneault E, Huang SH, O'Sullivan B, Waldron J, Boutros PC, Goldstein D, Meyer F, Xu W, Liu G. PMID: 27173062.
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    245. Clonality of localized and metastatic prostate cancer. Curr Opin Urol. 2016 May; 26(3):219-24. Boutros PC, Fraser M, van der Kwast T, Bristow RG. PMID: 26885716.
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    246. 2,3,7,8 Tetrachlorodibenzo-p-dioxin-induced RNA abundance changes identify Ackr3, Col18a1, Cyb5a and Glud1 as candidate mediators of toxicity. Arch Toxicol. 2017 Jan; 91(1):325-338. Watson JD, Prokopec SD, Smith AB, Okey AB, Pohjanvirta R, Boutros PC. PMID: 27136898; PMCID: PMC5225275.
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    247. PD-L1 and Tumor Infiltrating Lymphocytes as Prognostic Markers in Resected NSCLC. PLoS One. 2016; 11(4):e0153954. Ameratunga M, Asadi K, Lin X, Walkiewicz M, Murone C, Knight S, Mitchell P, Boutros P, John T. PMID: 27104612; PMCID: PMC4841565.
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    248. Allele-Skewed DNA Modification in the Brain: Relevance to a Schizophrenia GWAS. Am J Hum Genet. 2016 May 05; 98(5):956-962. Gagliano SA, Ptak C, Mak DYF, Shamsi M, Oh G, Knight J, Boutros PC, Petronis A. PMID: 27087318; PMCID: PMC4863558.
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    249. Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease. Alzheimers Dement. 2016 06; 12(6):645-53. Allen GI, Amoroso N, Anghel C, Balagurusamy V, Bare CJ, Beaton D, Bellotti R, Bennett DA, Boehme KL, Boutros PC, Caberlotto L, Caloian C, Campbell F, Chaibub Neto E, Chang YC, Chen B, Chen CY, Chien TY, Clark T, Das S, Davatzikos C, Deng J, Dillenberger D, Dobson RJ, Dong Q, Doshi J, Duma D, Errico R, Erus G, Everett E, Fardo DW, Friend SH, Fröhlich H, Gan J, St George-Hyslop P, Ghosh SS, Glaab E, Green RC, Guan Y, Hong MY, Huang C, Hwang J, Ibrahim J, Inglese P, Iyappan A, Jiang Q, Katsumata Y, Kauwe JS, Klein A, Kong D, Krause R, Lalonde E, Lauria M, Lee E, Lin X, Liu Z, Livingstone J, Logsdon BA, Lovestone S, Ma TW, Malhotra A, Mangravite LM, Maxwell TJ, Merrill E, Nagorski J, Namasivayam A, Narayan M, Naz M, Newhouse SJ, Norman TC, Nurtdinov RN, Oyang YJ, Pawitan Y, Peng S, Peters MA, Piccolo SR, Praveen P, Priami C, Sabelnykova VY, Senger P, Shen X, Simmons A, Sotiras A, Stolovitzky G, Tangaro S, Tateo A, Tung YA, Tustison NJ, Varol E, Vradenburg G, Weiner MW, Xiao G, Xie L, Xie Y, Xu J, Yang H, Zhan X, Zhou Y, Zhu F, Zhu H, Zhu S, Alzheimer's Disease Neuroimaging Initiative. PMID: 27079753; PMCID: PMC5474755.
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    250. PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma. J Transl Med. 2016 Mar 08; 14:67. Babichev Y, Kabaroff L, Datti A, Uehling D, Isaac M, Al-Awar R, Prakesch M, Sun RX, Boutros PC, Venier R, Dickson BC, Gladdy RA. PMID: 26952093; PMCID: PMC4782390.
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    251. Downregulation of histone H2A and H2B pathways is associated with anthracycline sensitivity in breast cancer. Breast Cancer Res. 2016 Feb 06; 18(1):16. Braunstein M, Liao L, Lyttle N, Lobo N, Taylor KJ, Krzyzanowski PM, Kalatskaya I, Yao CQ, Stein LD, Boutros PC, Twelves CJ, Marcellus R, Bartlett JM, Spears M. PMID: 26852132; PMCID: PMC4744406.
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    252. A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing. Nat Commun. 2015 Dec 09; 6:10001. Alioto TS, Buchhalter I, Derdak S, Hutter B, Eldridge MD, Hovig E, Heisler LE, Beck TA, Simpson JT, Tonon L, Sertier AS, Patch AM, Jäger N, Ginsbach P, Drews R, Paramasivam N, Kabbe R, Chotewutmontri S, Diessl N, Previti C, Schmidt S, Brors B, Feuerbach L, Heinold M, Gröbner S, Korshunov A, Tarpey PS, Butler AP, Hinton J, Jones D, Menzies A, Raine K, Shepherd R, Stebbings L, Teague JW, Ribeca P, Giner FC, Beltran S, Raineri E, Dabad M, Heath SC, Gut M, Denroche RE, Harding NJ, Yamaguchi TN, Fujimoto A, Nakagawa H, Quesada V, Valdés-Mas R, Nakken S, Vodák D, Bower L, Lynch AG, Anderson CL, Waddell N, Pearson JV, Grimmond SM, Peto M, Spellman P, He M, Kandoth C, Lee S, Zhang J, Létourneau L, Ma S, Seth S, Torrents D, Xi L, Wheeler DA, López-Otín C, Campo E, Campbell PJ, Boutros PC, Puente XS, Gerhard DS, Pfister SM, McPherson JD, Hudson TJ, Schlesner M, Lichter P, Eils R, Jones DT, Gut IG. PMID: 26647970; PMCID: PMC4682041.
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    253. A four gene signature predicts benefit from anthracyclines: evidence from the BR9601 and MA.5 clinical trials. Oncotarget. 2015 Oct 13; 6(31):31693-701. Spears M, Yousif F, Lyttle N, Boutros PC, Munro AF, Twelves C, Pritchard KI, Levine MN, Shepherd L, Bartlett JM. PMID: 26372731; PMCID: PMC4741633.
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    254. The path to routine use of genomic biomarkers in the cancer clinic. Genome Res. 2015 Oct; 25(10):1508-13. Boutros PC. PMID: 26430161; PMCID: PMC4579336.
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    255. miR-620 promotes tumor radioresistance by targeting 15-hydroxyprostaglandin dehydrogenase (HPGD). Oncotarget. 2015 Sep 08; 6(26):22439-51. Huang X, Taeb S, Jahangiri S, Korpela E, Cadonic I, Yu N, Krylov SN, Fokas E, Boutros PC, Liu SK. PMID: 26068950; PMCID: PMC4673174.
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    256. Male and female mice show significant differences in hepatic transcriptomic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin. BMC Genomics. 2015 Aug 20; 16:625. Lee J, Prokopec SD, Watson JD, Sun RX, Pohjanvirta R, Boutros PC. PMID: 26290441; PMCID: PMC4546048.
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    257. Transcriptional profiling of rat white adipose tissue response to 2,3,7,8-tetrachlorodibenzo-ρ-dioxin. Toxicol Appl Pharmacol. 2015 Oct 15; 288(2):223-31. Houlahan KE, Prokopec SD, Sun RX, Moffat ID, Lindén J, Lensu S, Okey AB, Pohjanvirta R, Boutros PC. PMID: 26232522.
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    258. Pathway and network analysis of cancer genomes. Nat Methods. 2015 Jul; 12(7):615-621. Creixell P, Reimand J, Haider S, Wu G, Shibata T, Vazquez M, Mustonen V, Gonzalez-Perez A, Pearson J, Sander C, Raphael BJ, Marks DS, Ouellette BFF, Valencia A, Bader GD, Boutros PC, Stuart JM, Linding R, Lopez-Bigas N, Stein LD, Mutation Consequences and Pathway Analysis Working Group of the International Cancer Genome Consorti. PMID: 26125594; PMCID: PMC4717906.
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    259. Corrigendum: analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue. Nat Genet. 2015 Jun; 47(6):689. Cooper CS, Eeles R, Wedge DC, Van Loo P, Gundem G, Alexandrov LB, Kremeyer B, Butler A, Lynch AG, Camacho N, Massie CE, Kay J, Luxton HJ, Edwards S, Kote-Jarai Z, Dennis N, Merson S, Leongamornlert D, Zamora J, Corbishley C, Thomas S, Nik-Zainal S, Ramakrishna M, O'Meara S, Matthews L, Clark J, Hurst R, Mithen R, Bristow RG, Boutros PC, Fraser M, Cooke S, Raine K, Jones D, Menzies A, Stebbings L, Hinton J, Teague J, McLaren S, Mudie L, Hardy C, Anderson E, Joseph O, Goody V, Robinson B, Maddison M, Gamble S, Greenman C, Berney D, Hazell S, Livni N, ICGC Prostate Group, Fisher C, Ogden C, Kumar P, Thompson A, Woodhouse C, Nicol D, Mayer E, Dudderidge T, Shah NC, Gnanapragasam V, Voet T, Campbell P, Futreal A, Easton D, Warren AY, Foster CS, Stratton MR, Whitaker HC, McDermott U, Brewer DS, Neal DE. PMID: 26018901.
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    260. Spatial genomic heterogeneity within localized, multifocal prostate cancer. Nat Genet. 2015 Jul; 47(7):736-45. Boutros PC, Fraser M, Harding NJ, de Borja R, Trudel D, Lalonde E, Meng A, Hennings-Yeomans PH, McPherson A, Sabelnykova VY, Zia A, Fox NS, Livingstone J, Shiah YJ, Wang J, Beck TA, Have CL, Chong T, Sam M, Johns J, Timms L, Buchner N, Wong A, Watson JD, Simmons TT, P'ng C, Zafarana G, Nguyen F, Luo X, Chu KC, Prokopec SD, Sykes J, Dal Pra A, Berlin A, Brown A, Chan-Seng-Yue MA, Yousif F, Denroche RE, Chong LC, Chen GM, Jung E, Fung C, Starmans MH, Chen H, Govind SK, Hawley J, D'Costa A, Pintilie M, Waggott D, Hach F, Lambin P, Muthuswamy LB, Cooper C, Eeles R, Neal D, Tetu B, Sahinalp C, Stein LD, Fleshner N, Shah SP, Collins CC, Hudson TJ, McPherson JD, van der Kwast T, Bristow RG. PMID: 26005866.
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    261. Combining tumor genome simulation with crowdsourcing to benchmark somatic single-nucleotide-variant detection. Nat Methods. 2015 Jul; 12(7):623-30. Ewing AD, Houlahan KE, Hu Y, Ellrott K, Caloian C, Yamaguchi TN, Bare JC, P'ng C, Waggott D, Sabelnykova VY, ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants, Kellen MR, Norman TC, Haussler D, Friend SH, Stolovitzky G, Margolin AA, Stuart JM, Boutros PC. PMID: 25984700; PMCID: PMC4856034.
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    262. ISOpureR: an R implementation of a computational purification algorithm of mixed tumour profiles. BMC Bioinformatics. 2015 May 14; 16:156. Anghel CV, Quon G, Haider S, Nguyen F, Deshwar AG, Morris QD, Boutros PC. PMID: 25972088; PMCID: PMC4429941.
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    263. Matching Kidneys and Urines: Establishing Noninvasive Surrogates of Intrarenal Events in Primary Glomerulonephritis. Semin Nephrol. 2015 May; 35(3):256-65. Reich HN, Sabelnykova VY, Boutros PC. PMID: 26215863.
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    265. Developing a prognostic micro-RNA signature for human cervical carcinoma. PLoS One. 2015; 10(4):e0123946. How C, Pintilie M, Bruce JP, Hui AB, Clarke BA, Wong P, Yin S, Yan R, Waggott D, Boutros PC, Fyles A, Hedley DW, Hill RP, Milosevic M, Liu FF. PMID: 25880806; PMCID: PMC4399941.
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    266. Appropriateness of using patient-derived xenograft models for pharmacologic evaluation of novel therapies for esophageal/gastro-esophageal junction cancers. PLoS One. 2015; 10(3):e0121872. Dodbiba L, Teichman J, Fleet A, Thai H, Starmans MH, Navab R, Chen Z, Girgis H, Eng L, Espin-Garcia O, Shen X, Bandarchi B, Schwock J, Tsao MS, El-Zimaity H, Der SD, Xu W, Bristow RG, Darling GE, Boutros PC, Ailles LE, Liu G. PMID: 25826681; PMCID: PMC4380353.
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    267. Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue. Nat Genet. 2015 Apr; 47(4):367-372. Cooper CS, Eeles R, Wedge DC, Van Loo P, Gundem G, Alexandrov LB, Kremeyer B, Butler A, Lynch AG, Camacho N, Massie CE, Kay J, Luxton HJ, Edwards S, Kote-Jarai Z, Dennis N, Merson S, Leongamornlert D, Zamora J, Corbishley C, Thomas S, Nik-Zainal S, O'Meara S, Matthews L, Clark J, Hurst R, Mithen R, Bristow RG, Boutros PC, Fraser M, Cooke S, Raine K, Jones D, Menzies A, Stebbings L, Hinton J, Teague J, McLaren S, Mudie L, Hardy C, Anderson E, Joseph O, Goody V, Robinson B, Maddison M, Gamble S, Greenman C, Berney D, Hazell S, Livni N, ICGC Prostate Group, Fisher C, Ogden C, Kumar P, Thompson A, Woodhouse C, Nicol D, Mayer E, Dudderidge T, Shah NC, Gnanapragasam V, Voet T, Campbell P, Futreal A, Easton D, Warren AY, Foster CS, Stratton MR, Whitaker HC, McDermott U, Brewer DS, Neal DE. PMID: 25730763; PMCID: PMC4380509.
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    268. Identification of a microRNA signature associated with risk of distant metastasis in nasopharyngeal carcinoma. Oncotarget. 2015 Feb 28; 6(6):4537-50. Bruce JP, Hui AB, Shi W, Perez-Ordonez B, Weinreb I, Xu W, Haibe-Kains B, Waggott DM, Boutros PC, O'Sullivan B, Waldron J, Huang SH, Chen EX, Gilbert R, Liu FF. PMID: 25738365; PMCID: PMC4414210.
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    269. Sex-related differences in murine hepatic transcriptional and proteomic responses to TCDD. Toxicol Appl Pharmacol. 2015 Apr 15; 284(2):188-96. Prokopec SD, Watson JD, Lee J, Pohjanvirta R, Boutros PC. PMID: 25703434.
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    270. A Progesterone-CXCR4 Axis Controls Mammary Progenitor Cell Fate in the Adult Gland. Stem Cell Reports. 2015 Mar 10; 4(3):313-322. Shiah YJ, Tharmapalan P, Casey AE, Joshi PA, McKee TD, Jackson HW, Beristain AG, Chan-Seng-Yue MA, Bader GD, Lydon JP, Waterhouse PD, Boutros PC, Khokha R. PMID: 28447939; PMCID: PMC4376056.
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    272. Integrating RAS status into prognostic signatures for adenocarcinomas of the lung. Clin Cancer Res. 2015 Mar 15; 21(6):1477-86. Starmans MH, Pintilie M, Chan-Seng-Yue M, Moon NC, Haider S, Nguyen F, Lau SK, Liu N, Kasprzyk A, Wouters BG, Der SD, Shepherd FA, Jurisica I, Penn LZ, Tsao MS, Lambin P, Boutros PC. PMID: 25609067.
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    276. NBN gain is predictive for adverse outcome following image-guided radiotherapy for localized prostate cancer. Oncotarget. 2014 Nov 30; 5(22):11081-90. Berlin A, Lalonde E, Sykes J, Zafarana G, Chu KC, Ramnarine VR, Ishkanian A, Sendorek DH, Pasic I, Lam WL, Jurisica I, van der Kwast T, Milosevic M, Boutros PC, Bristow RG. PMID: 25415046; PMCID: PMC4294365.
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    277. Exploiting high-throughput cell line drug screening studies to identify candidate therapeutic agents in head and neck cancer. BMC Pharmacol Toxicol. 2014 Nov 27; 15:66. Nichols AC, Black M, Yoo J, Pinto N, Fernandes A, Haibe-Kains B, Boutros PC, Barrett JW. PMID: 25428177; PMCID: PMC4258049.
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    279. Onco-proteogenomics: cancer proteomics joins forces with genomics. Nat Methods. 2014 Nov; 11(11):1107-13. Alfaro JA, Sinha A, Kislinger T, Boutros PC. PMID: 25357240.
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    280. Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER. Nat Commun. 2014 Oct 29; 5:5203. van den Beucken T, Koch E, Chu K, Rupaimoole R, Prickaerts P, Adriaens M, Voncken JW, Harris AL, Buffa FM, Haider S, Starmans MHW, Yao CQ, Ivan M, Ivan C, Pecot CV, Boutros PC, Sood AK, Koritzinsky M, Wouters BG. PMID: 25351418; PMCID: PMC4255228.
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    281. Identification of reference proteins for Western blot analyses in mouse model systems of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) toxicity. PLoS One. 2014; 9(10):e110730. Prokopec SD, Watson JD, Pohjanvirta R, Boutros PC. PMID: 25329058; PMCID: PMC4201576.
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    282. The transcriptomic profile of ovarian cancer grading. Cancer Med. 2015 Jan; 4(1):56-64. Yao CQ, Nguyen F, Haider S, Starmans MH, Lambin P, Boutros PC. PMID: 25314936; PMCID: PMC4312118.
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    283. Integrated omic analysis of oropharyngeal carcinomas reveals human papillomavirus (HPV)-dependent regulation of the activator protein 1 (AP-1) pathway. Mol Cell Proteomics. 2014 Dec; 13(12):3572-84. Sepiashvili L, Waggott D, Hui A, Shi W, Su S, Ignatchenko A, Ignatchenko V, Laureano M, Huang SH, Xu W, Weinreb I, Waldron J, O'Sullivan B, Irish JC, Boutros PC, Liu FF, Kislinger T. PMID: 25271301; PMCID: PMC4256506.
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    284. Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands. Nat Genet. 2014 Nov; 46(11):1166-9. Weinreb I, Piscuoglio S, Martelotto LG, Waggott D, Ng CK, Perez-Ordonez B, Harding NJ, Alfaro J, Chu KC, Viale A, Fusco N, da Cruz Paula A, Marchio C, Sakr RA, Lim R, Thompson LD, Chiosea SI, Seethala RR, Skalova A, Stelow EB, Fonseca I, Assaad A, How C, Wang J, de Borja R, Chan-Seng-Yue M, Howlett CJ, Nichols AC, Wen YH, Katabi N, Buchner N, Mullen L, Kislinger T, Wouters BG, Liu FF, Norton L, McPherson JD, Rubin BP, Clarke BA, Weigelt B, Boutros PC, Reis-Filho JS. PMID: 25240283; PMCID: PMC10208689.
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    286. Anti-nucleosome antibodies outperform traditional biomarkers as longitudinal indicators of disease activity in systemic lupus erythematosus. Rheumatology (Oxford). 2015 Mar; 54(3):449-57. Li T, Prokopec SD, Morrison S, Lou W, Reich H, Gladman D, Urowitz M, Scholey J, Fortin PR, Boutros PC, Wither J, Landolt-Marticorena C. PMID: 25193804; PMCID: PMC4334682.
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    287. SeqControl: process control for DNA sequencing. Nat Methods. 2014 Oct; 11(10):1071-5. Chong LC, Albuquerque MA, Harding NJ, Caloian C, Chan-Seng-Yue M, de Borja R, Fraser M, Denroche RE, Beck TA, van der Kwast T, Bristow RG, McPherson JD, Boutros PC. PMID: 25173705.
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    288. Novel PRKD gene rearrangements and variant fusions in cribriform adenocarcinoma of salivary gland origin. Genes Chromosomes Cancer. 2014 Oct; 53(10):845-56. Weinreb I, Zhang L, Tirunagari LM, Sung YS, Chen CL, Perez-Ordonez B, Clarke BA, Skalova A, Chiosea SI, Seethala RR, Waggott D, Boutros PC, How C, Liu FF, Irish JC, Goldstein DP, Gilbert R, Ud Din N, Assaad A, Hornick JL, Thompson LD, Antonescu CR. PMID: 24942367.
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    289. Ensemble analyses improve signatures of tumour hypoxia and reveal inter-platform differences. BMC Bioinformatics. 2014 Jun 06; 15:170. Fox NS, Starmans MH, Haider S, Lambin P, Boutros PC. PMID: 24902696; PMCID: PMC4061774.
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    290. Epigenetics in radiotherapy: where are we heading? Radiother Oncol. 2014 May; 111(2):168-77. Smits KM, Melotte V, Niessen HE, Dubois L, Oberije C, Troost EG, Starmans MH, Boutros PC, Vooijs M, van Engeland M, Lambin P. PMID: 24861629.
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    291. Haploinsufficiency of an RB-E2F1-Condensin II complex leads to aberrant replication and aneuploidy. Cancer Discov. 2014 Jul; 4(7):840-53. Coschi CH, Ishak CA, Gallo D, Marshall A, Talluri S, Wang J, Cecchini MJ, Martens AL, Percy V, Welch I, Boutros PC, Brown GW, Dick FA. PMID: 24740996.
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    292. Next-generation sequencing of urologic cancers: next is now. Eur Urol. 2014 Jul; 66(1):4-7. Real FX, Boutros PC, Malats N. PMID: 24731787.
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    293. Global optimization of somatic variant identification in cancer genomes with a global community challenge. Nat Genet. 2014 Apr; 46(4):318-319. Boutros PC, Ewing AD, Ellrott K, Norman TC, Dang KK, Hu Y, Kellen MR, Suver C, Bare JC, Stein LD, Spellman PT, Stolovitzky G, Friend SH, Margolin AA, Stuart JM. PMID: 24675517; PMCID: PMC4035501.
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    294. ShatterProof: operational detection and quantification of chromothripsis. BMC Bioinformatics. 2014 Mar 19; 15:78. Govind SK, Zia A, Hennings-Yeomans PH, Watson JD, Fraser M, Anghel C, Wyatt AW, van der Kwast T, Collins CC, McPherson JD, Bristow RG, Boutros PC. PMID: 24646301; PMCID: PMC3999944.
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    295. Systematic analysis of 18F-FDG PET and metabolism, proliferation and hypoxia markers for classification of head and neck tumors. BMC Cancer. 2014 Feb 26; 14:130. Hoeben BA, Starmans MH, Leijenaar RT, Dubois LJ, van der Kogel AJ, Kaanders JH, Boutros PC, Lambin P, Bussink J. PMID: 24571588; PMCID: PMC3940254.
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    296. Use of Sequenom sample ID Plus® SNP genotyping in identification of FFPE tumor samples. PLoS One. 2014; 9(2):e88163. Miller JK, Buchner N, Timms L, Tam S, Luo X, Brown AM, Pasternack D, Bristow RG, Fraser M, Boutros PC, McPherson JD. PMID: 24551080; PMCID: PMC3923782.
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    297. Identifying molecular features that distinguish fluvastatin-sensitive breast tumor cells. Breast Cancer Res Treat. 2014 Jan; 143(2):301-12. Goard CA, Chan-Seng-Yue M, Mullen PJ, Quiroga AD, Wasylishen AR, Clendening JW, Sendorek DH, Haider S, Lehner R, Boutros PC, Penn LZ. PMID: 24337703.
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    298. TCDD dysregulation of 13 AHR-target genes in rat liver. Toxicol Appl Pharmacol. 2014 Feb 01; 274(3):445-54. Watson JD, Prokopec SD, Smith AB, Okey AB, Pohjanvirta R, Boutros PC. PMID: 24355419.
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    299. Two phases of disulfide bond formation have differing requirements for oxygen. J Cell Biol. 2013 Nov 25; 203(4):615-27. Koritzinsky M, Levitin F, van den Beucken T, Rumantir RA, Harding NJ, Chu KC, Boutros PC, Braakman I, Wouters BG. PMID: 24247433; PMCID: PMC3840938.
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    300. Identification of genes expressed by immune cells of the colon that are regulated by colorectal cancer-associated variants. Int J Cancer. 2014 May 15; 134(10):2330-41. Peltekova VD, Lemire M, Qazi AM, Zaidi SH, Trinh QM, Bielecki R, Rogers M, Hodgson L, Wang M, D'Souza DJ, Zandi S, Chong T, Kwan JY, Kozak K, De Borja R, Timms L, Rangrej J, Volar M, Chan-Seng-Yue M, Beck T, Ash C, Lee S, Wang J, Boutros PC, Stein LD, Dick JE, Gryfe R, McPherson JD, Zanke BW, Pollett A, Gallinger S, Hudson TJ. PMID: 24154973; PMCID: PMC3949167.
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    302. MYC phosphorylation at novel regulatory regions suppresses transforming activity. Cancer Res. 2013 Nov 01; 73(21):6504-15. Wasylishen AR, Chan-Seng-Yue M, Bros C, Dingar D, Tu WB, Kalkat M, Chan PK, Mullen PJ, Huang L, Meyer N, Raught B, Boutros PC, Penn LZ. PMID: 24030976.
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    303. Genome-wide gene expression profiling of stress response in a spinal cord clip compression injury model. BMC Genomics. 2013 Aug 28; 14:583. Chamankhah M, Eftekharpour E, Karimi-Abdolrezaee S, Boutros PC, San-Marina S, Fehlings MG. PMID: 23984903; PMCID: PMC3846681.
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    306. The role of Cancer-Testis antigens as predictive and prognostic markers in non-small cell lung cancer. PLoS One. 2013; 8(7):e67876. John T, Starmans MH, Chen YT, Russell PA, Barnett SA, White SC, Mitchell PL, Walkiewicz M, Azad A, Lambin P, Tsao MS, Deb S, Altorki N, Wright G, Knight S, Boutros PC, Cebon JS. PMID: 23935846; PMCID: PMC3720740.
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    309. Long-term hemodynamic and molecular effects persist after discontinued renin-angiotensin system blockade in patients with type 1 diabetes mellitus. Kidney Int. 2013 Dec; 84(6):1246-53. Cherney DZ, Zinman B, Kennedy CR, Moineddin R, Lai V, Yang S, Miller JA, Prokopec SD, Boutros PC, Scholey JW, Reich HN. PMID: 23760288.
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    310. Role of Nek2 on centrosome duplication and aneuploidy in breast cancer cells. Oncogene. 2014 May 01; 33(18):2375-84. Cappello P, Blaser H, Gorrini C, Lin DC, Elia AJ, Wakeham A, Haider S, Boutros PC, Mason JM, Miller NA, Youngson B, Done SJ, Mak TW. PMID: 23708664.
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    311. Identifying gene locus associations with promyelocytic leukemia nuclear bodies using immuno-TRAP. J Cell Biol. 2013 Apr 15; 201(2):325-35. Ching RW, Ahmed K, Boutros PC, Penn LZ, Bazett-Jones DP. PMID: 23589495; PMCID: PMC3628506.
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    312. A case report and genetic characterization of a massive acinic cell carcinoma of the parotid with delayed distant metastases. Case Rep Oncol Med. 2013; 2013:270362. Nichols AC, Chan-Seng-Yue M, Yoo J, Agrawal SK, Starmans MH, Waggott D, Harding NJ, Dowthwaite SA, Palma DA, Fung K, Wehrli B, Macneil SD, Lambin P, Winquist E, Koropatnick J, Mymryk JS, Boutros PC, Barrett JW. PMID: 23653877; PMCID: PMC3638544.
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    315. Prophylactic valproic acid treatment prevents schizophrenia-related behaviour in Disc1-L100P mutant mice. PLoS One. 2012; 7(12):e51562. Lipina TV, Haque FN, McGirr A, Boutros PC, Berger T, Mak TW, Roder JC, Wong AH. PMID: 23272119; PMCID: PMC3525594.
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    316. A Pilot Study Comparing HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas by Whole Exome Sequencing. ISRN Oncol. 2012; 2012:809370. Nichols AC, Chan-Seng-Yue M, Yoo J, Xu W, Dhaliwal S, Basmaji J, Szeto CC, Dowthwaite S, Todorovic B, Starmans MH, Lambin P, Palma DA, Fung K, Franklin JH, Wehrli B, Kwan K, Koropatnick J, Mymryk JS, Boutros P, Barrett JW. PMID: 23304554; PMCID: PMC3530794.
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    318. Predicting outcomes in radiation oncology--multifactorial decision support systems. Nat Rev Clin Oncol. 2013 Jan; 10(1):27-40. Lambin P, van Stiphout RG, Starmans MH, Rios-Velazquez E, Nalbantov G, Aerts HJ, Roelofs E, van Elmpt W, Boutros PC, Granone P, Valentini V, Begg AC, De Ruysscher D, Dekker A. PMID: 23165123; PMCID: PMC4555846.
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    327. Risk factors for voriconazole hepatotoxicity at 12 weeks in lung transplant recipients. Am J Transplant. 2012 Jul; 12(7):1929-35. Luong ML, Hosseini-Moghaddam SM, Singer LG, Chaparro C, Azad S, Lazar N, Boutros PC, Keshavjee S, Rotstein C, Husain S. PMID: 22486950.
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    330. Inter-strain heterogeneity in rat hepatic transcriptomic responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicol Appl Pharmacol. 2012 Apr 15; 260(2):135-45. Yao CQ, Prokopec SD, Watson JD, Pang R, P'ng C, Chong LC, Harding NJ, Pohjanvirta R, Okey AB, Boutros PC. PMID: 22342509.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    331. Identification of a novel brain derived neurotrophic factor (BDNF)-inhibitory factor: regulation of BDNF by teneurin C-terminal associated peptide (TCAP)-1 in immortalized embryonic mouse hypothalamic cells. Regul Pept. 2012 Feb 10; 174(1-3):79-89. Ng T, Chand D, Song L, Al Chawaf A, Watson JD, Boutros PC, Belsham DD, Lovejoy DA. PMID: 22209827.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    332. Role of Pirh2 in mediating the regulation of p53 and c-Myc. PLoS Genet. 2011 Nov; 7(11):e1002360. Hakem A, Bohgaki M, Lemmers B, Tai E, Salmena L, Matysiak-Zablocki E, Jung YS, Karaskova J, Kaustov L, Duan S, Madore J, Boutros P, Sheng Y, Chesi M, Bergsagel PL, Perez-Ordonez B, Mes-Masson AM, Penn L, Squire J, Chen X, Jurisica I, Arrowsmith C, Sanchez O, Benchimol S, Hakem R. PMID: 22125490; PMCID: PMC3219591.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    333. Unsupervised detection of genes of influence in lung cancer using biological networks. Bioinformatics. 2011 Nov 15; 27(22):3166-72. Goldenberg A, Mostafavi S, Quon G, Boutros PC, Morris QD. PMID: 21965819.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    334. mRNA levels in control rat liver display strain-specific, hereditary, and AHR-dependent components. PLoS One. 2011; 6(7):e18337. Boutros PC, Moffat ID, Okey AB, Pohjanvirta R. PMID: 21760882; PMCID: PMC3132743.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    335. A tree-based approach for motif discovery and sequence classification. Bioinformatics. 2011 Aug 01; 27(15):2054-61. Yan R, Boutros PC, Jurisica I. PMID: 21685048.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    336. In-depth proteomics of ovarian cancer ascites: combining shotgun proteomics and selected reaction monitoring mass spectrometry. J Proteome Res. 2011 May 06; 10(5):2286-99. Elschenbroich S, Ignatchenko V, Clarke B, Kalloger SE, Boutros PC, Gramolini AO, Shaw P, Jurisica I, Kislinger T. PMID: 21491939.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    337. Teneurin C-terminal associated peptide (TCAP)-1 modulates dendritic morphology in hippocampal neurons and decreases anxiety-like behaviors in rats. Physiol Behav. 2011 Aug 03; 104(2):199-204. Tan LA, Al Chawaf A, Vaccarino FJ, Boutros PC, Lovejoy DA. PMID: 21411044.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    338. Molecular markers of injury in kidney biopsy specimens of patients with lupus nephritis. J Mol Diagn. 2011 Mar; 13(2):143-51. Reich HN, Landolt-Marticorena C, Boutros PC, John R, Wither J, Fortin PR, Yang S, Scholey JW, Herzenberg AM. PMID: 21354048; PMCID: PMC3128621.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    339. VennDiagram: a package for the generation of highly-customizable Venn and Euler diagrams in R. BMC Bioinformatics. 2011 Jan 26; 12:35. Chen H, Boutros PC. PMID: 21269502; PMCID: PMC3041657.
      View in: PubMed   Mentions: 1152     Fields:    
    340. Hepatic transcriptomic responses to TCDD in dioxin-sensitive and dioxin-resistant rats during the onset of toxicity. Toxicol Appl Pharmacol. 2011 Mar 01; 251(2):119-29. Boutros PC, Yao CQ, Watson JD, Wu AH, Moffat ID, Prokopec SD, Smith AB, Okey AB, Pohjanvirta R. PMID: 21215274.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    341. Differential interactions between statins and P-glycoprotein: implications for exploiting statins as anticancer agents. Int J Cancer. 2010 Dec 15; 127(12):2936-48. Goard CA, Mather RG, Vinepal B, Clendening JW, Martirosyan A, Boutros PC, Sharom FJ, Penn LZ. PMID: 21351272.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    342. Re: Gene expression-based prognostic signatures in lung cancer: ready for clinical use? J Natl Cancer Inst. 2010 Nov 03; 102(21):1677-8; author reply 1678-9. Boutros PC, Pintilie M, John T, Starmans MH, Der SD, Shepherd FA, Tsao MS, Jurisica I. PMID: 20921041.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    343. LTR: Linear Cross-Platform Integration of Microarray Data. Cancer Inform. 2010 Aug 27; 9:197-208. Boutros PC. PMID: 20838609; PMCID: PMC2935818.
      View in: PubMed   Mentions: 2  
    344. Dysregulation of the mevalonate pathway promotes transformation. Proc Natl Acad Sci U S A. 2010 Aug 24; 107(34):15051-6. Clendening JW, Pandyra A, Boutros PC, El Ghamrasni S, Khosravi F, Trentin GA, Martirosyan A, Hakem A, Hakem R, Jurisica I, Penn LZ. PMID: 20696928; PMCID: PMC2930553.
      View in: PubMed   Mentions: 193     Fields:    Translation:HumansAnimalsCells
    345. Characterization of the apoptotic response of human leukemia cells to organosulfur compounds. BMC Cancer. 2010 Jul 02; 10:351. Wong WW, Boutros PC, Wasylishen AR, Guckert KD, O'Brien EM, Griffiths R, Martirosyan AR, Bros C, Jurisica I, Langler RF, Penn LZ. PMID: 20598143; PMCID: PMC2928001.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    346. Aryl hydrocarbon receptor is a transcriptional activator of the human breast cancer resistance protein (BCRP/ABCG2). Mol Pharmacol. 2010 Aug; 78(2):175-85. Tan KP, Wang B, Yang M, Boutros PC, Macaulay J, Xu H, Chuang AI, Kosuge K, Yamamoto M, Takahashi S, Wu AM, Ross DD, Harper PA, Ito S. PMID: 20460431.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    347. Aryl hydrocarbon receptor (AHR)-regulated transcriptomic changes in rats sensitive or resistant to major dioxin toxicities. BMC Genomics. 2010 Apr 26; 11:263. Moffat ID, Boutros PC, Chen H, Okey AB, Pohjanvirta R. PMID: 20420666; PMCID: PMC2881023.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    348. International network of cancer genome projects. Nature. 2010 Apr 15; 464(7291):993-8. International Cancer Genome Consortium, Hudson TJ, Anderson W, Artez A, Barker AD, Bell C, Bernabé RR, Bhan MK, Calvo F, Eerola I, Gerhard DS, Guttmacher A, Guyer M, Hemsley FM, Jennings JL, Kerr D, Klatt P, Kolar P, Kusada J, Lane DP, Laplace F, Youyong L, Nettekoven G, Ozenberger B, Peterson J, Rao TS, Remacle J, Schafer AJ, Shibata T, Stratton MR, Vockley JG, Watanabe K, Yang H, Yuen MM, Knoppers BM, Bobrow M, Cambon-Thomsen A, Dressler LG, Dyke SO, Joly Y, Kato K, Kennedy KL, Nicolás P, Parker MJ, Rial-Sebbag E, Romeo-Casabona CM, Shaw KM, Wallace S, Wiesner GL, Zeps N, Lichter P, Biankin AV, Chabannon C, Chin L, Clément B, de Alava E, Degos F, Ferguson ML, Geary P, Hayes DN, Hudson TJ, Johns AL, Kasprzyk A, Nakagawa H, Penny R, Piris MA, Sarin R, Scarpa A, Shibata T, van de Vijver M, Futreal PA, Aburatani H, Bayés M, Botwell DD, Campbell PJ, Estivill X, Gerhard DS, Grimmond SM, Gut I, Hirst M, López-Otín C, Majumder P, Marra M, McPherson JD, Nakagawa H, Ning Z, Puente XS, Ruan Y, Shibata T, Stratton MR, Stunnenberg HG, Swerdlow H, Velculescu VE, Wilson RK, Xue HH, Yang L, Spellman PT, Bader GD, Boutros PC, Campbell PJ, Flicek P, Getz G, Guigó R, Guo G, Haussler D, Heath S, Hubbard TJ, Jiang T, Jones SM, Li Q, López-Bigas N, Luo R, Muthuswamy L, Ouellette BF, Pearson JV, Puente XS, Quesada V, Raphael BJ, Sander C, Shibata T, Speed TP, Stein LD, Stuart JM, Teague JW, Totoki Y, Tsunoda T, Valencia A, Wheeler DA, Wu H, Zhao S, Zhou G, Stein LD, Guigó R, Hubbard TJ, Joly Y, Jones SM, Kasprzyk A, Lathrop M, López-Bigas N, Ouellette BF, Spellman PT, Teague JW, Thomas G, Valencia A, Yoshida T, Kennedy KL, Axton M, Dyke SO, Futreal PA, Gerhard DS, Gunter C, Guyer M, Hudson TJ, McPherson JD, Miller LJ, Ozenberger B, Shaw KM, Kasprzyk A, Stein LD, Zhang J, Haider SA, Wang J, Yung CK, Cros A, Cross A, Liang Y, Gnaneshan S, Guberman J, Hsu J, Bobrow M, Chalmers DR, Hasel KW, Joly Y, Kaan TS, Kennedy KL, Knoppers BM, Lowrance WW, Masui T, Nicolás P, Rial-Sebbag E, Rodriguez LL, Vergely C, Yoshida T, Grimmond SM, Biankin AV, Bowtell DD, Cloonan N, deFazio A, Eshleman JR, Etemadmoghadam D, Gardiner BB, Gardiner BA, Kench JG, Scarpa A, Sutherland RL, Tempero MA, Waddell NJ, Wilson PJ, McPherson JD, Gallinger S, Tsao MS, Shaw PA, Petersen GM, Mukhopadhyay D, Chin L, DePinho RA, Thayer S, Muthuswamy L, Shazand K, Beck T, Sam M, Timms L, Ballin V, Lu Y, Ji J, Zhang X, Chen F, Hu X, Zhou G, Yang Q, Tian G, Zhang L, Xing X, Li X, Zhu Z, Yu Y, Yu J, Yang H, Lathrop M, Tost J, Brennan P, Holcatova I, Zaridze D, Brazma A, Egevard L, Prokhortchouk E, Banks RE, Uhlén M, Cambon-Thomsen A, Viksna J, Ponten F, Skryabin K, Stratton MR, Futreal PA, Birney E, Borg A, Børresen-Dale AL, Caldas C, Foekens JA, Martin S, Reis-Filho JS, Richardson AL, Sotiriou C, Stunnenberg HG, Thoms G, van de Vijver M, van't Veer L, Calvo F, Birnbaum D, Blanche H, Boucher P, Boyault S, Chabannon C, Gut I, Masson-Jacquemier JD, Lathrop M, Pauporté I, Pivot X, Vincent-Salomon A, Tabone E, Theillet C, Thomas G, Tost J, Treilleux I, Calvo F, Bioulac-Sage P, Clément B, Decaens T, Degos F, Franco D, Gut I, Gut M, Heath S, Lathrop M, Samuel D, Thomas G, Zucman-Rossi J, Lichter P, Eils R, Brors B, Korbel JO, Korshunov A, Landgraf P, Lehrach H, Pfister S, Radlwimmer B, Reifenberger G, Taylor MD, von Kalle C, Majumder PP, Sarin R, Rao TS, Bhan MK, Scarpa A, Pederzoli P, Lawlor RA, Delledonne M, Bardelli A, Biankin AV, Grimmond SM, Gress T, Klimstra D, Zamboni G, Shibata T, Nakamura Y, Nakagawa H, Kusada J, Tsunoda T, Miyano S, Aburatani H, Kato K, Fujimoto A, Yoshida T, Campo E, López-Otín C, Estivill X, Guigó R, de Sanjosé S, Piris MA, Montserrat E, González-Díaz M, Puente XS, Jares P, Valencia A, Himmelbauer H, et al. PMID: 20393554; PMCID: PMC2902243.
      View in: PubMed   Mentions: 1129     Fields:    Translation:HumansCells
    349. Exploiting the mevalonate pathway to distinguish statin-sensitive multiple myeloma. Blood. 2010 Jun 10; 115(23):4787-97. Clendening JW, Pandyra A, Li Z, Boutros PC, Martirosyan A, Lehner R, Jurisica I, Trudel S, Penn LZ. PMID: 20360469.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    350. Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors. Cancer Cell. 2009 Dec 08; 16(6):533-46. Li M, Lee KF, Lu Y, Clarke I, Shih D, Eberhart C, Collins VP, Van Meter T, Picard D, Zhou L, Boutros PC, Modena P, Liang ML, Scherer SW, Bouffet E, Rutka JT, Pomeroy SL, Lau CC, Taylor MD, Gajjar A, Dirks PB, Hawkins CE, Huang A. PMID: 19962671; PMCID: PMC3431561.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansAnimalsCells
    351. Dioxin-dependent and dioxin-independent gene batteries: comparison of liver and kidney in AHR-null mice. Toxicol Sci. 2009 Nov; 112(1):245-56. Boutros PC, Bielefeld KA, Pohjanvirta R, Harper PA. PMID: 19759094; PMCID: PMC2769058.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    352. Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model. Hum Mol Genet. 2009 Sep 01; 18(17):3227-43. Labrie V, Fukumura R, Rastogi A, Fick LJ, Wang W, Boutros PC, Kennedy JL, Semeralul MO, Lee FH, Baker GB, Belsham DD, Barger SW, Gondo Y, Wong AH, Roder JC. PMID: 19483194; PMCID: PMC2722985.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimals
    353. Robust global micro-RNA profiling with formalin-fixed paraffin-embedded breast cancer tissues. Lab Invest. 2009 May; 89(5):597-606. Hui AB, Shi W, Boutros PC, Miller N, Pintilie M, Fyles T, McCready D, Wong D, Gerster K, Waldron L, Jurisica I, Penn LZ, Liu FF. PMID: 19290006.
      View in: PubMed   Mentions: 118     Fields:    Translation:Humans
    354. Prognostic gene signatures for non-small-cell lung cancer. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2824-8. Boutros PC, Lau SK, Pintilie M, Liu N, Shepherd FA, Der SD, Tsao MS, Penn LZ, Jurisica I. PMID: 19196983; PMCID: PMC2636731.
      View in: PubMed   Mentions: 111     Fields:    Translation:Humans
    355. Optimization of experimental design parameters for high-throughput chromatin immunoprecipitation studies. Nucleic Acids Res. 2008 Dec; 36(21):e144. Ponzielli R, Boutros PC, Katz S, Stojanova A, Hanley AP, Khosravi F, Bros C, Jurisica I, Penn LZ. PMID: 18940864; PMCID: PMC2588500.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    356. Transcriptomic responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in liver: comparison of rat and mouse. BMC Genomics. 2008 Sep 16; 9:419. Boutros PC, Yan R, Moffat ID, Pohjanvirta R, Okey AB. PMID: 18796159; PMCID: PMC2559853.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
    357. Aryl hydrocarbon receptor-dependent induction of flavin-containing monooxygenase mRNAs in mouse liver. Drug Metab Dispos. 2008 Dec; 36(12):2499-505. Celius T, Roblin S, Harper PA, Matthews J, Boutros PC, Pohjanvirta R, Okey AB. PMID: 18765683; PMCID: PMC5003606.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    358. Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function. Cancer Res. 2008 Aug 15; 68(16):6688-97. Beheshti Zavareh R, Lau KS, Hurren R, Datti A, Ashline DJ, Gronda M, Cheung P, Simpson CD, Liu W, Wasylishen AR, Boutros PC, Shi H, Vengopal A, Jurisica I, Penn LZ, Reinhold VN, Ezzat S, Wrana J, Rose DR, Schachter H, Dennis JW, Schimmer AD. PMID: 18701493.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    359. Patterns of dioxin-altered mRNA expression in livers of dioxin-sensitive versus dioxin-resistant rats. Arch Toxicol. 2008 Nov; 82(11):809-30. Franc MA, Moffat ID, Boutros PC, Tuomisto JT, Tuomisto J, Pohjanvirta R, Okey AB. PMID: 18465118.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    360. Genome-wide effects of acute progressive feed restriction in liver and white adipose tissue. Toxicol Appl Pharmacol. 2008 Jul 01; 230(1):41-56. Pohjanvirta R, Boutros PC, Moffat ID, Lindén J, Wendelin D, Okey AB. PMID: 18394668.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    361. Web-based resources for clinical bioinformatics. Methods Mol Med. 2008; 141:309-29. Joshua AM, Boutros PC. PMID: 18453097.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    362. Three-gene prognostic classifier for early-stage non small-cell lung cancer. J Clin Oncol. 2007 Dec 10; 25(35):5562-9. Lau SK, Boutros PC, Pintilie M, Blackhall FH, Zhu CQ, Strumpf D, Johnston MR, Darling G, Keshavjee S, Waddell TK, Liu N, Lau D, Penn LZ, Shepherd FA, Jurisica I, Der SD, Tsao MS. PMID: 18065728.
      View in: PubMed   Mentions: 111     Fields:    Translation:Humans
    363. CUL7 is a novel antiapoptotic oncogene. Cancer Res. 2007 Oct 15; 67(20):9616-22. Kim SS, Shago M, Kaustov L, Boutros PC, Clendening JW, Sheng Y, Trentin GA, Barsyte-Lovejoy D, Mao DY, Kay R, Jurisica I, Arrowsmith CH, Penn LZ. PMID: 17942889.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    364. Changes in gene expression induced by tienilic Acid and sulfamethoxazole: testing the danger hypothesis. J Immunotoxicol. 2007 Oct; 4(4):253-66. Pacitto SR, Uetrecht JP, Boutros PC, Popovic M. PMID: 18958736.
      View in: PubMed   Mentions: 1     Fields:    
    365. microRNAs in adult rodent liver are refractory to dioxin treatment. Toxicol Sci. 2007 Oct; 99(2):470-87. Moffat ID, Boutros PC, Celius T, Lindén J, Pohjanvirta R, Okey AB. PMID: 17698510.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    366. Determinants of sensitivity to lovastatin-induced apoptosis in multiple myeloma. Mol Cancer Ther. 2007 Jun; 6(6):1886-97. Wong WW, Clendening JW, Martirosyan A, Boutros PC, Bros C, Khosravi F, Jurisica I, Stewart AK, Bergsagel PL, Penn LZ. PMID: 17575117.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    367. Microarray analysis of the developing cortex. J Neurobiol. 2006 Dec; 66(14):1646-58. Semeralul MO, Boutros PC, Likhodi O, Okey AB, Van Tol HH, Wong AH. PMID: 17013924.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    368. Gene expression profiling in cervical cancer: an exploration of intratumor heterogeneity. Clin Cancer Res. 2006 Oct 01; 12(19):5632-40. Bachtiary B, Boutros PC, Pintilie M, Shi W, Bastianutto C, Li JH, Schwock J, Zhang W, Penn LZ, Jurisica I, Fyles A, Liu FF. PMID: 17020965.
      View in: PubMed   Mentions: 72     Fields:    Translation:Humans
    369. The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis. Cancer Res. 2006 May 15; 66(10):5330-7. Barsyte-Lovejoy D, Lau SK, Boutros PC, Khosravi F, Jurisica I, Andrulis IL, Tsao MS, Penn LZ. PMID: 16707459.
      View in: PubMed   Mentions: 257     Fields:    Translation:HumansAnimalsCells
    370. Differential expression profiling of the hepatic proteome in a rat model of dioxin resistance: correlation with genomic and transcriptomic analyses. Mol Cell Proteomics. 2006 May; 5(5):882-94. Pastorelli R, Carpi D, Campagna R, Airoldi L, Pohjanvirta R, Viluksela M, Hakansson H, Boutros PC, Moffat ID, Okey AB, Fanelli R. PMID: 16497791.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    371. Evaluation of various housekeeping genes for their applicability for normalization of mRNA expression in dioxin-treated rats. Chem Biol Interact. 2006 Mar 25; 160(2):134-49. Pohjanvirta R, Niittynen M, Lindén J, Boutros PC, Moffat ID, Okey AB. PMID: 16466705.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    372. dbZach: A MIAME-compliant toxicogenomic supportive relational database. Toxicol Sci. 2006 Apr; 90(2):558-68. Burgoon LD, Boutros PC, Dere E, Zacharewski TR. PMID: 16403854.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    373. Unsupervised pattern recognition: an introduction to the whys and wherefores of clustering microarray data. Brief Bioinform. 2005 Dec; 6(4):331-43. Boutros PC, Okey AB. PMID: 16420732.
      View in: PubMed   Mentions: 34     Fields:    
    374. Aryl hydrocarbon receptor regulates distinct dioxin-dependent and dioxin-independent gene batteries. Mol Pharmacol. 2006 Jan; 69(1):140-53. Tijet N, Boutros PC, Moffat ID, Okey AB, Tuomisto J, Pohjanvirta R. PMID: 16214954.
      View in: PubMed   Mentions: 124     Fields:    Translation:AnimalsCells
    375. Toxicological implications of polymorphisms in receptors for xenobiotic chemicals: the case of the aryl hydrocarbon receptor. Toxicol Appl Pharmacol. 2005 Sep 01; 207(2 Suppl):43-51. Okey AB, Franc MA, Moffat ID, Tijet N, Boutros PC, Korkalainen M, Tuomisto J, Pohjanvirta R. PMID: 15993909.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    376. Gene expression profiling in a model of D-penicillamine-induced autoimmunity in the Brown Norway rat: predictive value of early signs of danger. Chem Res Toxicol. 2005 Aug; 18(8):1193-202. Séguin B, Boutros PC, Li X, Okey AB, Uetrecht JP. PMID: 16097792.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    377. Polymorphisms of human nuclear receptors that control expression of drug-metabolizing enzymes. Pharmacogenet Genomics. 2005 Jun; 15(6):371-9. Okey AB, Boutros PC, Harper PA. PMID: 15900209.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    378. CpG Island microarray probe sequences derived from a physical library are representative of CpG Islands annotated on the human genome. Nucleic Acids Res. 2005; 33(9):2952-61. Heisler LE, Torti D, Boutros PC, Watson J, Chan C, Winegarden N, Takahashi M, Yau P, Huang TH, Farnham PJ, Jurisica I, Woodgett JR, Bremner R, Penn LZ, Der SD. PMID: 15911630; PMCID: PMC1137027.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    379. Dioxin-responsive AHRE-II gene battery: identification by phylogenetic footprinting. Biochem Biophys Res Commun. 2004 Aug 27; 321(3):707-15. Boutros PC, Moffat ID, Franc MA, Tijet N, Tuomisto J, Pohjanvirta R, Okey AB. PMID: 15358164.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    380. PUNS: transcriptomic- and genomic-in silico PCR for enhanced primer design. Bioinformatics. 2004 Oct 12; 20(15):2399-400. Boutros PC, Okey AB. PMID: 15073008.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
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