Paul Christopher Boutros

Title(s)Professor, Human Genetics
ORCID ORCID Icon0000-0003-0553-7520 Additional info
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    Other Positions
    Title(s)Professor, Urology

    Collapse Biography 
    Collapse Education and Training
    University of Toronto , CanadaExecutive MBA2016Business Administration
    University of Waterloo , CanadaB.Sc.2004Chemistry
    University of Toronto , CanadaPhD2008Medical Biophysics
    Institute of Genetics, Canadian Institutes of Health Research, Canada2017Sex and Gender in Biomedical Research Workshop
    Rotman School of Management, University of Toronto, Canada2017Rotman-UHN Leadership Training Program
    Collapse Awards and Honors
    Journal of the National Cancer Institute2019  - 2020Top 25 Peer Reviewer
    Canadian Cancer Society20182018 Bernard and Francine Dorval Prize
    European Urology2018Reviewer of the Month
    Rotman School of Management, University of Toronto2016Dean’s List & Bregman’s Scholar
    Faculty of Medicine Graduate Teaching Award, University of Toronto2016Early Career Excellence in Graduate Teaching and Mentorship
    University of Waterloo, Faculty of Science2015Young Alumni Award
    DREAM AML Prognosis Challenge Sub-Challenge 2: Remission Duration20141st Place
    DREAM AML Prognosis Challenge Sub-Challenge 3: Overall Survival Time20141st Place
    Prostate Cancer Canada2013Travel Award
    Prostate Cancer Canada2012Collaboration Exploration and Development Award
    Canadian Cancer Society Research Institute2010CCSRI Junior Investigator Grant Panel Travel Award
    The 17th International Conference on Intelligent Systems for Molecular Biology2009Travel Award
    The 11th International Meeting of the Microarray and Gene Expression Data Society2008Travel Award (declined)
    Department of Medical Biophysics Harold Johns Memorial Prize2008First Place Oral Presentation
    BioConductor Workshop 20082008Travel Award
    International Society for Computational Biology Student Council2008Travel Award
    National Cancer Institute of Canada2007Travel Award
    Canadian Cancer Society2007Travel Award
    UHN Research Day 20062006Abstract Winner
    Canadian Institutes for Health Research / BioContact-Québec2006First Place CIHR Next Generation Award
    Canadian Institutes for Health Research / BioContact-Québec2006Travel Award
    Invitrogen Canada, Inc.2006Invitrogen Canada Young Investigator Silver Award
    Natural Sciences and Engineering Research Council2006  - 2009CGS Postgraduate Fellowship
    Excellence in Radiation Research for the 21st Century CIHR STIHR2006  - 2008CIHR Strategic Training Fellowship Alumni Award
    The Government of Ontario2006  - 2007Ontario Graduate Scholarship (declined)
    25th International Symposium on Halogenated Environmental Organic Pollutants and POPs2005Student Presenter Award
    CIHR EIRR21st Research Day2005Best Presentation Award
    Excellence in Radiation Research for the 21st Century CIHR STIHR2005  - 2007CIHR Strategic Training Fellowship (2007 declined)
    Institute for Robotics and Intelligent Systems2004PRECARN Fellowship
    15th International Symposium on Microsomes and Drug Oxidations; Mainz, Germany2004First Prize, Poster Presentations
    National Undergraduate Chemistry Conference2003First Place, Overall
    National Undergraduate Chemistry Conference2003Travel Award
    Southwestern Ontario Undergraduate Conference2003Second Place, Biochemistry Presentation
    University of Waterloo, Faculty of Science2002Dean’s Honour List
    Dow Canada Environmental Chemistry2001Work-Term Report Award

    Collapse Overview 
    Collapse Overview
    Paul Boutros, Ph.D., M.B.A., is a renowned data scientist and professor in the departments of human genetics and urology at the David Geffen School of Medicine at UCLA. He currently serves as director of the UCLA Jonsson Comprehensive Cancer Center’s Cancer Data Science program, Associate Director of cancer informatics at the UCLA Institute for Precision Health, and is a member of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research.

    The research in Boutros’ laboratory lies at the intersection of clinical, molecular and imaging data. He focuses on how these diverse pieces of information can be linked to personalize therapy for cancer patients. By applying techniques from modern data science strategies, particularly machine-learning, he creates biomarkers to help ensure therapies are selected that maximize cure and minimize morbidities. His work sometimes centers on specific tumor types, particularly prostate and thyroid, but often includes others in conjunction to identify general and tumor-type specific features of cancer. Some of his recent studies focus on how cancers develop differently based on the sex, age or ethnic features of the patient.

    Boutros has published over 200 peer-reviewed papers, and in his leadership roles as professor in the departments of human genetics and urology, he is currently working to support personalizing therapy for cancer by developing novel statistical methodologies. He leads the ICGC-TCGA DREAM Somatic Mutation Calling Challenge that is setting global standards for analyzing cancer genomic data, and drives programs in cancer genomics, data science and biomarker translation.

    Collapse Research 
    Collapse Research Activities and Funding
    The Influence of Germline Variation on Prostate Cancer RNA Circularization
    Prostate Cancer Foundation Sep 1, 2020 - Aug 1, 2022
    Role: PI
    Description: The major goal of this project is to identify if germline genomic features shape the circular RNA landscape of localized prostate cancer.
    The Evolution of Sarcoma Drug Sensitivity through Time and Space
    NIH R01CA244729Jul 1, 2020 - Jun 30, 2025
    Role: Co-Principal Investigator
    Advancing method benchmarking and data sharing through crowd-sourced competitions in cancer research
    NIH U24CA248265Jul 1, 2020 - Jun 30, 2025
    Role: Co-Principal Investigator
    Comparing the Nuclear, Mitochondrial and Microenvironmental Evolution of Adult & Pediatric Brain Cancers
    UCLA Developmental Research Program Jul 1, 2020 - Jun 1, 2021
    Role: PI
    Description: The major goal of this project is to investigate the evolutionary trajectories of pediatric and adult brain cancer through changes in mitochondrial numbers, hypoxia, and tumor evolution.
    Expanding the Prostate Cancer Proteome: Identity & Function of Non-Canonical ORFs
    UCLA Developmental Research Program Jul 1, 2020 - Jun 1, 2020
    Role: PI
    Description: The major goal of this project is to develop a database of non-canonical proteins in lethal prostate cancer and associate these proteins with clinico-molecular phenotypes.
    Characterization of Novel Molecular Signature for Accurately Predicting Prostate Cancer Progression in Active Surveillance
    The University of Calgary Feb 1, 2020 - Dec 1, 2023
    Role: Co-Investigator
    Description: The main goal of this project is to identify if the TMPRSS2-ERG fusion gene, PTEN genomic deletions and SPINK1 as individual or combined markers explains the metastatic potential of prostate cancer cells.
    Identification and Characterization of Oncometabolite-induced DNA Repair Defects in Sporadic Papillary Kidney Cancer
    The Hope Foundation Jan 1, 2020 - Dec 1, 2020
    Role: Co-Investigator
    Molecular Characterization and Behavior of Tumors Arising in Patients Taking 5-alpha Reductase Inhibitors
    University Health Network Nov 1, 2019 - Jul 1, 2000
    Role: PI
    PRECEPT – PRostate CancEr Prognosis and Treatment
    The University of Melbourne Jan 1, 2019 - Jan 1, 2021
    Role: Site-PI
    Description: The major goal of this project is to identify changes in the genomic/epigenomic/transcriptional landscape of prostate cancer that drives progression of localized disease.
    Development of Protein Biomarkers in Post-DRE Urine for use in Liquid Biopsy of Prostate Cancer
    NIH U01CA214194Sep 15, 2016 - Aug 31, 2022
    Role: Co-Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Methylation Subtypes of Primary Prostate Cancer Predict Poor Prognosis. Cancer Epidemiol Biomarkers Prev. 2022 Jul 01; 31(7):1473-1482. Wang X, Jordahl KM, Zhu C, Livingstone J, Rhie SK, Wright JL, Grady WM, Boutros PC, Stanford JL, Dai JY. PMID: 35437583; PMCID: PMC9250603.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    2. Estimation of tumor cell total mRNA expression in 15 cancer types predicts disease progression. Nat Biotechnol. 2022 Jun 13. Cao S, Wang JR, Ji S, Yang P, Dai Y, Guo S, Montierth MD, Shen JP, Zhao X, Chen J, Lee JJ, Guerrero PA, Spetsieris N, Engedal N, Taavitsainen S, Yu K, Livingstone J, Bhandari V, Hubert SM, Daw NC, Futreal PA, Efstathiou E, Lim B, Viale A, Zhang J, Nykter M, Czerniak BA, Brown PH, Swanton C, Msaouel P, Maitra A, Kopetz S, Campbell P, Speed TP, Boutros PC, Zhu H, Urbanucci A, Demeulemeester J, Van Loo P, Wang W. PMID: 35697807.
      View in: PubMed   Mentions:    Fields:    
    3. Prostate cancer multiparametric magnetic resonance imaging visibility is a tumor-intrinsic phenomena. J Hematol Oncol. 2022 05 03; 15(1):48. Khoo A, Liu LY, Sadun TY, Salmasi A, Pooli A, Felker E, Houlahan KE, Ignatchenko V, Raman SS, Sisk AE, Reiter RE, Boutros PC, Kislinger T. PMID: 35505417; PMCID: PMC9066728.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Virally programmed extracellular vesicles sensitize cancer cells to oncolytic virus and small molecule therapy. Nat Commun. 2022 04 07; 13(1):1898. Wedge ME, Jennings VA, Crupi MJF, Poutou J, Jamieson T, Pelin A, Pugliese G, de Souza CT, Petryk J, Laight BJ, Boileau M, Taha Z, Alluqmani N, McKay HE, Pikor L, Khan ST, Azad T, Rezaei R, Austin B, He X, Mansfield D, Rose E, Brown EEF, Crawford N, Alkayyal A, Surendran A, Singaravelu R, Roy DG, Migneco G, McSweeney B, Cottee ML, Jacobus EJ, Keller BA, Yamaguchi TN, Boutros PC, Geoffrion M, Rayner KJ, Chatterjee A, Auer RC, Diallo JS, Gibbings D, tenOever BR, Melcher A, Bell JC, Ilkow CS. PMID: 35393414; PMCID: PMC8990073.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Establishment of four Head and Neck Squamous Cell Carcinoma Cell Lines: Importance of Reference DNA is Essential for accurate genomic characterization. J Laryngol Otol. 2022 Mar 23; 1-21. Patel KB, Prokopec S, Barrett JW, Mymryk JS, Boutros PC, Nichols AC. PMID: 35317874.
      View in: PubMed   Mentions:    Fields:    
    6. Data-driven identification of inherent features of eukaryotic stress-responsive genes. NAR Genom Bioinform. 2022 Mar; 4(1):lqac018. Latorre P, Böttcher R, Nadal-Ribelles M, Li CH, Solé C, Martínez-Cebrián G, Boutros PC, Posas F, de Nadal E. PMID: 35265837; PMCID: PMC8900196.
      View in: PubMed   Mentions:
    7. Serological abnormalities that predict progression to systemic autoimmune rheumatic diseases in antinuclear antibody-positive individuals. Rheumatology (Oxford). 2022 03 02; 61(3):1092-1105. Muñoz-Grajales C, Prokopec SD, Johnson SR, Touma Z, Ahmad Z, Bonilla D, Hiraki L, Bookman A, Boutros PC, Chruscinski A, Wither J. PMID: 34175923; PMCID: PMC8889298.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    8. Interplay Between Duration of Androgen Deprivation Therapy and External Beam Radiotherapy With or Without a Brachytherapy Boost for Optimal Treatment of High-risk Prostate Cancer: A Patient-Level Data Analysis of 3 Cohorts. JAMA Oncol. 2022 Mar 01; 8(3):e216871. Kishan AU, Steigler A, Denham JW, Zapatero A, Guerrero A, Joseph D, Maldonado X, Wong JK, Stish BJ, Dess RT, Pilar A, Reddy C, Wedde TB, Lilleby WA, Fiano R, Merrick GS, Stock RG, Demanes DJ, Moran BJ, Tran PT, Martin S, Martinez-Monge R, Krauss DJ, Abu-Isa EI, Pisansky TM, Choo CR, Song DY, Greco S, Deville C, McNutt T, DeWeese TL, Ross AE, Ciezki JP, Tilki D, Karnes RJ, Tosoian JJ, Nickols NG, Bhat P, Shabsovich D, Juarez JE, Jiang T, Ma TM, Xiang M, Philipson R, Chang A, Kupelian PA, Rettig MB, Feng FY, Berlin A, Tward JD, Davis BJ, Reiter RE, Steinberg ML, Elashoff D, Boutros PC, Horwitz EM, Tendulkar RD, Spratt DE, Romero T. PMID: 35050303; PMCID: PMC8778608.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. Optimization of small extracellular vesicle isolation from expressed prostatic secretions in urine for in-depth proteomic analysis. J Extracell Vesicles. 2022 02; 11(2):e12184. Correll VL, Otto JJ, Risi CM, Main BP, Boutros PC, Kislinger T, Galkin VE, Nyalwidhe JO, Semmes OJ, Yang L. PMID: 35119778; PMCID: PMC8815402.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. Age influences on the molecular presentation of tumours. Nat Commun. 2022 01 11; 13(1):208. Li CH, Haider S, Boutros PC. PMID: 35017538; PMCID: PMC8752853.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    11. HLA-A∗02:01 restricted T cell receptors against the highly conserved SARS-CoV-2 polymerase cross-react with human coronaviruses. Cell Rep. 2021 12 28; 37(13):110167. Nesterenko PA, McLaughlin J, Tsai BL, Burton Sojo G, Cheng D, Zhao D, Mao Z, Bangayan NJ, Obusan MB, Su Y, Ng RH, Chour W, Xie J, Li YR, Lee D, Noguchi M, Carmona C, Phillips JW, Kim JT, Yang L, Heath JR, Boutros PC, Witte ON. PMID: 34919800; PMCID: PMC8660260.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    12. Comparison of Response to Definitive Radiotherapy for Localized Prostate Cancer in Black and White Men: A Meta-analysis. JAMA Netw Open. 2021 12 01; 4(12):e2139769. Ma TM, Romero T, Nickols NG, Rettig MB, Garraway IP, Roach M, Michalski JM, Pisansky TM, Lee WR, Jones CU, Rosenthal SA, Wang C, Hartman H, Nguyen PL, Feng FY, Boutros PC, Saigal C, Chamie K, Jackson WC, Morgan TM, Mehra R, Salami SS, Vince R, Schaeffer EM, Mahal BA, Dess RT, Steinberg ML, Elashoff D, Sandler HM, Spratt DE, Kishan AU. PMID: 34964855; PMCID: PMC8717118.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. Performance of a Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography-Derived Risk-Stratification Tool for High-risk and Very High-risk Prostate Cancer. JAMA Netw Open. 2021 12 01; 4(12):e2138550. Xiang M, Ma TM, Savjani R, Pollom EL, Karnes RJ, Grogan T, Wong JK, Motterle G, Tosoian JJ, Trock BJ, Klein EA, Stish BJ, Dess RT, Spratt DE, Pilar A, Reddy C, Levin-Epstein R, Wedde TB, Lilleby WA, Fiano R, Merrick GS, Stock RG, Demanes DJ, Moran BJ, Huland H, Tran PT, Martin S, Martinez-Monge R, Krauss DJ, Abu-Isa EI, Alam R, Schwen Z, Pisansky TM, Choo CR, Song DY, Greco S, Deville C, McNutt T, DeWeese TL, Ross AE, Ciezki JP, Boutros PC, Nickols NG, Bhat P, Shabsovich D, Juarez JE, Chong N, Kupelian PA, Rettig MB, Zaorsky NG, Berlin A, Tward JD, Davis BJ, Reiter RE, Steinberg ML, Elashoff D, Horwitz EM, Tendulkar RD, Tilki D, Czernin J, Gafita A, Romero T, Calais J, Kishan AU. PMID: 34902034; PMCID: PMC8669522.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    14. The telomere length landscape of prostate cancer. Nat Commun. 2021 11 25; 12(1):6893. Livingstone J, Shiah YJ, Yamaguchi TN, Heisler LE, Huang V, Lesurf R, Gebo T, Carlin B, Eng S, Drysdale E, Green J, van der Kwast T, Bristow RG, Fraser M, Boutros PC. PMID: 34824250; PMCID: PMC8617305.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    15. A Canadian Study of Cisplatin Metabolomics and Nephrotoxicity (ACCENT): A Clinical Research Protocol. Can J Kidney Health Dis. 2021; 8:20543581211057708. Jain A, Huang R, Lee J, Jawa N, Lim YJ, Guron M, Abish S, Boutros PC, Brudno M, Carleton B, Cuvelier GDE, Gunaratnam L, Ho C, Adeli K, Kuruvilla S, Lajoie G, Liu G, Nathan PC, Rod Rassekh S, Rieder M, Waikar SS, Welch SA, Weir MA, Winquist E, Wishart DS, Zorzi AP, Blydt-Hansen T, Zappitelli M, Urquhart B. PMID: 34820133; PMCID: PMC8606978.
      View in: PubMed   Mentions:
    16. Refining the definition of biochemical failure in the era of stereotactic body radiation therapy for prostate cancer: The Phoenix definition and beyond. Radiother Oncol. 2022 01; 166:1-7. Ma TM, Roy S, Wu X, Mantz C, Fuller D, Miszczyk L, Napieralska A, Namysl-Kaletka A, Bagshaw HP, Buyyounouski MK, Glicksman R, Loblaw DA, Katz A, Upadhyaya SK, Nickols N, Steinberg ML, Philipson R, Aghdam N, Suy S, Pepin A, Collins SP, Boutros P, Rettig MB, Calais J, Wang M, Zaorsky N, Kishan AU. PMID: 34774650.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    17. Sex Differences in Cancer Genomes: Much Learned, More Unknown. Endocrinology. 2021 11 01; 162(11). Zhu C, Boutros PC. PMID: 34402895; PMCID: PMC8439393.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    18. Fumarate hydratase variant prevalence and manifestations among individuals receiving germline testing. Cancer. 2022 02 15; 128(4):675-684. Lu E, Hatchell KE, Nielsen SM, Esplin ED, Ouyang K, Nykamp K, Zavoshi S, Li S, Zhang L, Wilde BR, Christofk HR, Boutros PC, Shuch B. PMID: 34724198; PMCID: PMC9170268.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    19. Somatic driver mutation prevalence in 1844 prostate cancers identifies ZNRF3 loss as a predictor of metastatic relapse. Nat Commun. 2021 10 29; 12(1):6248. Fraser M, Livingstone J, Wrana JL, Finelli A, He HH, van der Kwast T, Zlotta AR, Bristow RG, Boutros PC. PMID: 34716314; PMCID: PMC8556363.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    20. 3p Arm Loss and Survival in Head and Neck Cancer: An Analysis of TCGA Dataset. Cancers (Basel). 2021 Oct 22; 13(21). Kim HAJ, Shaikh MH, Lee M, Zeng PYF, Sorgini A, Akintola T, Deng X, Jarycki L, Khan H, MacNeil D, Khan MI, Mendez A, Yoo J, Fung K, Lang P, Palma DA, Patel K, Mymryk JS, Barrett JW, Boutros PC, Morris LGT, Nichols AC. PMID: 34771477; PMCID: PMC8582539.
      View in: PubMed   Mentions:
    21. Reorganization of the 3D Genome Pinpoints Noncoding Drivers of Primary Prostate Tumors. Cancer Res. 2021 12 01; 81(23):5833-5848. Hawley JR, Zhou S, Arlidge C, Grillo G, Kron KJ, Hugh-White R, van der Kwast TH, Fraser M, Boutros PC, Bristow RG, Lupien M. PMID: 34642184.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    22. Proteomic discovery of non-invasive biomarkers of localized prostate cancer using mass spectrometry. Nat Rev Urol. 2021 12; 18(12):707-724. Khoo A, Liu LY, Nyalwidhe JO, Semmes OJ, Vesprini D, Downes MR, Boutros PC, Liu SK, Kislinger T. PMID: 34453155; PMCID: PMC8639658.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    23. A clinically applicable integrative molecular classification of meningiomas. Nature. 2021 09; 597(7874):119-125. Nassiri F, Liu J, Patil V, Mamatjan Y, Wang JZ, Hugh-White R, Macklin AM, Khan S, Singh O, Karimi S, Corona RI, Liu LY, Chen CY, Chakravarthy A, Wei Q, Mehani B, Suppiah S, Gao A, Workewych AM, Tabatabai G, Boutros PC, Bader GD, de Carvalho DD, Kislinger T, Aldape K, Zadeh G. PMID: 34433969.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    24. Loss of CDCP1 triggers FAK activation in detached prostate cancer cells. Am J Clin Exp Urol. 2021; 9(4):350-366. Pollan SG, Teng PC, Jan YJ, Livingstone J, Huang C, Kim M, Mariscal J, Rodriguez M, Chen JF, You S, DiVizio D, Boutros PC, Chan KS, Rasorenova O, Cress A, Spassov D, Moasser M, Posadas EM, Freedland SJ, Freeman MR, Zheng JJ, Knudsen BS. PMID: 34541033; PMCID: PMC8446766.
      View in: PubMed   Mentions: 1  
    25. Comparative survival analysis of multiparametric tests-when molecular tests disagree-A TEAM Pathology study. NPJ Breast Cancer. 2021 Jul 08; 7(1):90. Bartlett JMS, Bayani J, Kornaga E, Xu K, Pond GR, Piper T, Mallon E, Yao CQ, Boutros PC, Hasenburg A, Dunn JA, Markopoulos C, Dirix L, Seynaeve C, van de Velde CJH, Stein RC, Rea D. PMID: 34238931; PMCID: PMC8266887.
      View in: PubMed   Mentions:
    26. Comparison of Multimodal Therapies and Outcomes Among Patients With High-Risk Prostate Cancer With Adverse Clinicopathologic Features. JAMA Netw Open. 2021 07 01; 4(7):e2115312. Kishan AU, Karnes RJ, Romero T, Wong JK, Motterle G, Tosoian JJ, Trock BJ, Klein EA, Stish BJ, Dess RT, Spratt DE, Pilar A, Reddy C, Levin-Epstein R, Wedde TB, Lilleby WA, Fiano R, Merrick GS, Stock RG, Demanes DJ, Moran BJ, Braccioforte M, Huland H, Tran PT, Martin S, Martínez-Monge R, Krauss DJ, Abu-Isa EI, Alam R, Schwen Z, Chang AJ, Pisansky TM, Choo R, Song DY, Greco S, Deville C, McNutt T, DeWeese TL, Ross AE, Ciezki JP, Boutros PC, Nickols NG, Bhat P, Shabsovich D, Juarez JE, Chong N, Kupelian PA, D'Amico AV, Rettig MB, Berlin A, Tward JD, Davis BJ, Reiter RE, Steinberg ML, Elashoff D, Horwitz EM, Tendulkar RD, Tilki D. PMID: 34196715; PMCID: PMC8251338.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    27. A proteomic investigation of isogenic radiation resistant prostate cancer cell lines. Proteomics Clin Appl. 2021 09; 15(5):e2100037. Kurganovs N, Wang H, Huang X, Ignatchenko V, Macklin A, Khan S, Downes MR, Boutros PC, Liu SK, Kislinger T. PMID: 34152685; PMCID: PMC8448965.
      View in: PubMed   Mentions: 1     Fields:    
    28. A community challenge to evaluate RNA-seq, fusion detection, and isoform quantification methods for cancer discovery. Cell Syst. 2021 08 18; 12(8):827-838.e5. Creason A, Haan D, Dang K, Chiotti KE, Inkman M, Lamb A, Yu T, Hu Y, Norman TC, Buchanan A, van Baren MJ, Spangler R, Rollins MR, Spellman PT, Rozanov D, Zhang J, Maher CA, Caloian C, Watson JD, Uhrig S, Haas BJ, Jain M, Akeson M, Ahsen ME, SMC-RNA Challenge Participants, Stolovitzky G, Guinney J, Boutros PC, Stuart JM, Ellrott K. PMID: 34146471; PMCID: PMC8376800.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    29. Decreased ATM Protein Expression Is Substantiated with PTEN Loss in Defining Aggressive Phenotype of Prostate Cancer Associated with Lethal Disease. Eur Urol Open Sci. 2021 Jul; 29:93-101. Walker SR, Abdelsalam R, Ghosh S, Livingstone J, Palanisamy N, Boutros PC, Yip SM, Lees-Miller SP, Bismar TA. PMID: 34337539; PMCID: PMC8317877.
      View in: PubMed   Mentions: 2  
    30. Precision Radiotherapy: Reduction in Radiation for Oropharyngeal Cancer in the 30 ROC Trial. J Natl Cancer Inst. 2021 06 01; 113(6):742-751. Riaz N, Sherman E, Pei X, Schöder H, Grkovski M, Paudyal R, Katabi N, Selenica P, Yamaguchi TN, Ma D, Lee SK, Shah R, Kumar R, Kuo F, Ratnakumar A, Aleynick N, Brown D, Zhang Z, Hatzoglou V, Liu LY, Salcedo A, Tsai CJ, McBride S, Morris LGT, Boyle J, Singh B, Higginson DS, Damerla RR, Paula ADC, Price K, Moore EJ, Garcia JJ, Foote R, Ho A, Wong RJ, Chan TA, Powell SN, Boutros PC, Humm JL, Shukla-Dave A, Pfister D, Reis-Filho JS, Lee N. PMID: 33429428; PMCID: PMC8168141.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCTClinical Trials
    31. Aging of the progenitor cells that initiate prostate cancer. Cancer Lett. 2021 09 01; 515:28-35. Freeland J, Crowell PD, Giafaglione JM, Boutros PC, Goldstein AS. PMID: 34052326; PMCID: PMC8494000.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    32. Copy Number Profiles of Prostate Cancer in Men of Middle Eastern Ancestry. Cancers (Basel). 2021 May 14; 13(10). Albawardi A, Livingstone J, Almarzooqi S, Palanisamy N, Houlahan KE, Awwad AAA, Abdelsalam RA, Boutros PC, Bismar TA. PMID: 34068856; PMCID: PMC8153627.
      View in: PubMed   Mentions: 1  
    33. Patterns of Clinical Progression in Radiorecurrent High-risk Prostate Cancer. Eur Urol. 2021 08; 80(2):142-146. Philipson RG, Romero T, Wong JK, Stish BJ, Dess RT, Spratt DE, Pilar A, Reddy C, Wedde TB, Lilleby WA, Fiano R, Merrick GS, Stock RG, Demanes DJ, Moran BJ, Braccioforte M, Tran PT, Martin S, Martinez-Monge R, Krauss DJ, Abu-Isa EI, Valle L, Chong N, Pisansky TM, Choo CR, Song DY, Greco S, Deville C, McNutt T, DeWeese TL, Ross AE, Ciezki JP, Tilki D, Karnes RJ, Klein EA, Tosoian JJ, Boutros PC, Nickols NG, Bhat P, Shabsovich D, Juarez JE, Kupelian PA, Rettig MB, Berlin A, Tward JD, Davis BJ, Reiter RE, Steinberg ML, Elashoff D, Horwitz EM, Tendulkar RD, Kishan AU. PMID: 33985797.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    34. NOX4 links metabolic regulation in pancreatic cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4. Sci Adv. 2021 05; 7(19). Jain P, Dvorkin-Gheva A, Mollen E, Malbeteau L, Xie M, Jessa F, Dhavarasa P, Chung S, Brown KR, Jang GH, Vora P, Notta F, Moffat J, Hedley D, Boutros PC, Wouters BG, Koritzinsky M. PMID: 33962950; PMCID: PMC8104867.
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    181. A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing. Nat Commun. 2015 Dec 09; 6:10001. Alioto TS, Buchhalter I, Derdak S, Hutter B, Eldridge MD, Hovig E, Heisler LE, Beck TA, Simpson JT, Tonon L, Sertier AS, Patch AM, Jäger N, Ginsbach P, Drews R, Paramasivam N, Kabbe R, Chotewutmontri S, Diessl N, Previti C, Schmidt S, Brors B, Feuerbach L, Heinold M, Gröbner S, Korshunov A, Tarpey PS, Butler AP, Hinton J, Jones D, Menzies A, Raine K, Shepherd R, Stebbings L, Teague JW, Ribeca P, Giner FC, Beltran S, Raineri E, Dabad M, Heath SC, Gut M, Denroche RE, Harding NJ, Yamaguchi TN, Fujimoto A, Nakagawa H, Quesada V, Valdés-Mas R, Nakken S, Vodák D, Bower L, Lynch AG, Anderson CL, Waddell N, Pearson JV, Grimmond SM, Peto M, Spellman P, He M, Kandoth C, Lee S, Zhang J, Létourneau L, Ma S, Seth S, Torrents D, Xi L, Wheeler DA, López-Otín C, Campo E, Campbell PJ, Boutros PC, Puente XS, Gerhard DS, Pfister SM, McPherson JD, Hudson TJ, Schlesner M, Lichter P, Eils R, Jones DT, Gut IG. PMID: 26647970; PMCID: PMC4682041.
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    182. A four gene signature predicts benefit from anthracyclines: evidence from the BR9601 and MA.5 clinical trials. Oncotarget. 2015 Oct 13; 6(31):31693-701. Spears M, Yousif F, Lyttle N, Boutros PC, Munro AF, Twelves C, Pritchard KI, Levine MN, Shepherd L, Bartlett JM. PMID: 26372731; PMCID: PMC4741633.
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    184. miR-620 promotes tumor radioresistance by targeting 15-hydroxyprostaglandin dehydrogenase (HPGD). Oncotarget. 2015 Sep 08; 6(26):22439-51. Huang X, Taeb S, Jahangiri S, Korpela E, Cadonic I, Yu N, Krylov SN, Fokas E, Boutros PC, Liu SK. PMID: 26068950; PMCID: PMC4673174.
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    186. Transcriptional profiling of rat white adipose tissue response to 2,3,7,8-tetrachlorodibenzo-ρ-dioxin. Toxicol Appl Pharmacol. 2015 Oct 15; 288(2):223-31. Houlahan KE, Prokopec SD, Sun RX, Moffat ID, Lindén J, Lensu S, Okey AB, Pohjanvirta R, Boutros PC. PMID: 26232522.
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    187. Pathway and network analysis of cancer genomes. Nat Methods. 2015 Jul; 12(7):615-621. Creixell P, Reimand J, Haider S, Wu G, Shibata T, Vazquez M, Mustonen V, Gonzalez-Perez A, Pearson J, Sander C, Raphael BJ, Marks DS, Ouellette BFF, Valencia A, Bader GD, Boutros PC, Stuart JM, Linding R, Lopez-Bigas N, Stein LD, Mutation Consequences and Pathway Analysis Working Group of the International Cancer Genome Consorti. PMID: 26125594; PMCID: PMC4717906.
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    188. Corrigendum: analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue. Nat Genet. 2015 Jun; 47(6):689. Cooper CS, Eeles R, Wedge DC, Van Loo P, Gundem G, Alexandrov LB, Kremeyer B, Butler A, Lynch AG, Camacho N, Massie CE, Kay J, Luxton HJ, Edwards S, Kote-Jarai Z, Dennis N, Merson S, Leongamornlert D, Zamora J, Corbishley C, Thomas S, Nik-Zainal S, Ramakrishna M, O'Meara S, Matthews L, Clark J, Hurst R, Mithen R, Bristow RG, Boutros PC, Fraser M, Cooke S, Raine K, Jones D, Menzies A, Stebbings L, Hinton J, Teague J, McLaren S, Mudie L, Hardy C, Anderson E, Joseph O, Goody V, Robinson B, Maddison M, Gamble S, Greenman C, Berney D, Hazell S, Livni N, ICGC Prostate Group, Fisher C, Ogden C, Kumar P, Thompson A, Woodhouse C, Nicol D, Mayer E, Dudderidge T, Shah NC, Gnanapragasam V, Voet T, Campbell P, Futreal A, Easton D, Warren AY, Foster CS, Stratton MR, Whitaker HC, McDermott U, Brewer DS, Neal DE. PMID: 26018901.
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    190. Combining tumor genome simulation with crowdsourcing to benchmark somatic single-nucleotide-variant detection. Nat Methods. 2015 Jul; 12(7):623-30. Ewing AD, Houlahan KE, Hu Y, Ellrott K, Caloian C, Yamaguchi TN, Bare JC, P'ng C, Waggott D, Sabelnykova VY, ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants, Kellen MR, Norman TC, Haussler D, Friend SH, Stolovitzky G, Margolin AA, Stuart JM, Boutros PC. PMID: 25984700; PMCID: PMC4856034.
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    191. ISOpureR: an R implementation of a computational purification algorithm of mixed tumour profiles. BMC Bioinformatics. 2015 May 14; 16:156. Anghel CV, Quon G, Haider S, Nguyen F, Deshwar AG, Morris QD, Boutros PC. PMID: 25972088; PMCID: PMC4429941.
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    192. Biomarkers and subtypes of cancer. Aging (Albany NY). 2015 May; 7(5):280-1. Starmans MH, Boutros PC. PMID: 26021974; PMCID: PMC4468304.
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    193. Matching Kidneys and Urines: Establishing Noninvasive Surrogates of Intrarenal Events in Primary Glomerulonephritis. Semin Nephrol. 2015 May; 35(3):256-65. Reich HN, Sabelnykova VY, Boutros PC. PMID: 26215863.
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    194. Developing a prognostic micro-RNA signature for human cervical carcinoma. PLoS One. 2015; 10(4):e0123946. How C, Pintilie M, Bruce JP, Hui AB, Clarke BA, Wong P, Yin S, Yan R, Waggott D, Boutros PC, Fyles A, Hedley DW, Hill RP, Milosevic M, Liu FF. PMID: 25880806; PMCID: PMC4399941.
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    195. Appropriateness of using patient-derived xenograft models for pharmacologic evaluation of novel therapies for esophageal/gastro-esophageal junction cancers. PLoS One. 2015; 10(3):e0121872. Dodbiba L, Teichman J, Fleet A, Thai H, Starmans MH, Navab R, Chen Z, Girgis H, Eng L, Espin-Garcia O, Shen X, Bandarchi B, Schwock J, Tsao MS, El-Zimaity H, Der SD, Xu W, Bristow RG, Darling GE, Boutros PC, Ailles LE, Liu G. PMID: 25826681; PMCID: PMC4380353.
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    209. Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER. Nat Commun. 2014 Oct 29; 5:5203. van den Beucken T, Koch E, Chu K, Rupaimoole R, Prickaerts P, Adriaens M, Voncken JW, Harris AL, Buffa FM, Haider S, Starmans MHW, Yao CQ, Ivan M, Ivan C, Pecot CV, Boutros PC, Sood AK, Koritzinsky M, Wouters BG. PMID: 25351418; PMCID: PMC4255228.
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    210. Identification of reference proteins for Western blot analyses in mouse model systems of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) toxicity. PLoS One. 2014; 9(10):e110730. Prokopec SD, Watson JD, Pohjanvirta R, Boutros PC. PMID: 25329058; PMCID: PMC4201576.
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    215. Anti-nucleosome antibodies outperform traditional biomarkers as longitudinal indicators of disease activity in systemic lupus erythematosus. Rheumatology (Oxford). 2015 Mar; 54(3):449-57. Li T, Prokopec SD, Morrison S, Lou W, Reich H, Gladman D, Urowitz M, Scholey J, Fortin PR, Boutros PC, Wither J, Landolt-Marticorena C. PMID: 25193804; PMCID: PMC4334682.
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    233. TMPRSS2-ERG status is not prognostic following prostate cancer radiotherapy: implications for fusion status and DSB repair. Clin Cancer Res. 2013 Sep 15; 19(18):5202-9. Dal Pra A, Lalonde E, Sykes J, Warde F, Ishkanian A, Meng A, Maloff C, Srigley J, Joshua AM, Petrovics G, van der Kwast T, Evans A, Milosevic M, Saad F, Collins C, Squire J, Lam W, Bismar TA, Boutros PC, Bristow RG. PMID: 23918607.
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    235. The role of Cancer-Testis antigens as predictive and prognostic markers in non-small cell lung cancer. PLoS One. 2013; 8(7):e67876. John T, Starmans MH, Chen YT, Russell PA, Barnett SA, White SC, Mitchell PL, Walkiewicz M, Azad A, Lambin P, Tsao MS, Deb S, Altorki N, Wright G, Knight S, Boutros PC, Cebon JS. PMID: 23935846; PMCID: PMC3720740.
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    236. MicroRNA-196b regulates the homeobox B7-vascular endothelial growth factor axis in cervical cancer. PLoS One. 2013; 8(7):e67846. How C, Hui AB, Alajez NM, Shi W, Boutros PC, Clarke BA, Yan R, Pintilie M, Fyles A, Hedley DW, Hill RP, Milosevic M, Liu FF. PMID: 23861821; PMCID: PMC3701631.
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    238. Long-term hemodynamic and molecular effects persist after discontinued renin-angiotensin system blockade in patients with type 1 diabetes mellitus. Kidney Int. 2013 Dec; 84(6):1246-53. Cherney DZ, Zinman B, Kennedy CR, Moineddin R, Lai V, Yang S, Miller JA, Prokopec SD, Boutros PC, Scholey JW, Reich HN. PMID: 23760288.
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    239. Role of Nek2 on centrosome duplication and aneuploidy in breast cancer cells. Oncogene. 2014 May 01; 33(18):2375-84. Cappello P, Blaser H, Gorrini C, Lin DC, Elia AJ, Wakeham A, Haider S, Boutros PC, Mason JM, Miller NA, Youngson B, Done SJ, Mak TW. PMID: 23708664.
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    240. Identifying gene locus associations with promyelocytic leukemia nuclear bodies using immuno-TRAP. J Cell Biol. 2013 Apr 15; 201(2):325-35. Ching RW, Ahmed K, Boutros PC, Penn LZ, Bazett-Jones DP. PMID: 23589495; PMCID: PMC3628506.
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    241. A case report and genetic characterization of a massive acinic cell carcinoma of the parotid with delayed distant metastases. Case Rep Oncol Med. 2013; 2013:270362. Nichols AC, Chan-Seng-Yue M, Yoo J, Agrawal SK, Starmans MH, Waggott D, Harding NJ, Dowthwaite SA, Palma DA, Fung K, Wehrli B, Macneil SD, Lambin P, Winquist E, Koropatnick J, Mymryk JS, Boutros PC, Barrett JW. PMID: 23653877; PMCID: PMC3638544.
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    243. Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies. Lancet Oncol. 2013 Apr; 14(4):327-34. Rushlow DE, Mol BM, Kennett JY, Yee S, Pajovic S, Thériault BL, Prigoda-Lee NL, Spencer C, Dimaras H, Corson TW, Pang R, Massey C, Godbout R, Jiang Z, Zacksenhaus E, Paton K, Moll AC, Houdayer C, Raizis A, Halliday W, Lam WL, Boutros PC, Lohmann D, Dorsman JC, Gallie BL. PMID: 23498719.
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    244. Prophylactic valproic acid treatment prevents schizophrenia-related behaviour in Disc1-L100P mutant mice. PLoS One. 2012; 7(12):e51562. Lipina TV, Haque FN, McGirr A, Boutros PC, Berger T, Mak TW, Roder JC, Wong AH. PMID: 23272119; PMCID: PMC3525594.
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    245. Systematic evaluation of medium-throughput mRNA abundance platforms. RNA. 2013 Jan; 19(1):51-62. Prokopec SD, Watson JD, Waggott DM, Smith AB, Wu AH, Okey AB, Pohjanvirta R, Boutros PC. PMID: 23169800; PMCID: PMC3527726.
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    246. Predicting outcomes in radiation oncology--multifactorial decision support systems. Nat Rev Clin Oncol. 2013 Jan; 10(1):27-40. Lambin P, van Stiphout RG, Starmans MH, Rios-Velazquez E, Nalbantov G, Aerts HJ, Roelofs E, van Elmpt W, Boutros PC, Granone P, Valentini V, Begg AC, De Ruysscher D, Dekker A. PMID: 23165123; PMCID: PMC4555846.
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    247. Exploiting the noise: improving biomarkers with ensembles of data analysis methodologies. Genome Med. 2012; 4(11):84. Starmans MH, Pintilie M, John T, Der SD, Shepherd FA, Jurisica I, Lambin P, Tsao MS, Boutros PC. PMID: 23146350; PMCID: PMC3580418.
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    248. Identification of differentially expressed proteins in direct expressed prostatic secretions of men with organ-confined versus extracapsular prostate cancer. Mol Cell Proteomics. 2012 Dec; 11(12):1870-84. Kim Y, Ignatchenko V, Yao CQ, Kalatskaya I, Nyalwidhe JO, Lance RS, Gramolini AO, Troyer DA, Stein LD, Boutros PC, Medin JA, Semmes OJ, Drake RR, Kislinger T. PMID: 22986220; PMCID: PMC3518113.
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    249. Expression profiling during mammary epithelial cell three-dimensional morphogenesis identifies PTPRO as a novel regulator of morphogenesis and ErbB2-mediated transformation. Mol Cell Biol. 2012 Oct; 32(19):3913-24. Yu M, Lin G, Arshadi N, Kalatskaya I, Xue B, Haider S, Nguyen F, Boutros PC, Elson A, Muthuswamy LB, Tonks NK, Muthuswamy SK. PMID: 22851698; PMCID: PMC3457532.
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    251. Independent and functional validation of a multi-tumour-type proliferation signature. Br J Cancer. 2012 Jul 24; 107(3):508-15. Starmans MH, Lieuwes NG, Span PN, Haider S, Dubois L, Nguyen F, van Laarhoven HW, Sweep FC, Wouters BG, Boutros PC, Lambin P. PMID: 22722312; PMCID: PMC3405210.
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    252. C-Terminal region of teneurin-1 co-localizes with dystroglycan and modulates cytoskeletal organization through an extracellular signal-regulated kinase-dependent stathmin- and filamin A-mediated mechanism in hippocampal cells. Neuroscience. 2012 Sep 06; 219:255-70. Chand D, Song L, deLannoy L, Barsyte-Lovejoy D, Ackloo S, Boutros PC, Evans K, Belsham DD, Lovejoy DA. PMID: 22698694.
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    253. Epigenetic markers of prostate cancer in plasma circulating DNA. Hum Mol Genet. 2012 Aug 15; 21(16):3619-31. Cortese R, Kwan A, Lalonde E, Bryzgunova O, Bondar A, Wu Y, Gordevicius J, Park M, Oh G, Kaminsky Z, Tverkuviene J, Laurinavicius A, Jankevicius F, Sendorek DH, Haider S, Wang SC, Jarmalaite S, Laktionov P, Boutros PC, Petronis A. PMID: 22619380.
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    254. NanoStringNorm: an extensible R package for the pre-processing of NanoString mRNA and miRNA data. Bioinformatics. 2012 Jun 01; 28(11):1546-8. Waggott D, Chu K, Yin S, Wouters BG, Liu FF, Boutros PC. PMID: 22513995; PMCID: PMC3356845.
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    255. Risk factors for voriconazole hepatotoxicity at 12 weeks in lung transplant recipients. Am J Transplant. 2012 Jul; 12(7):1929-35. Luong ML, Hosseini-Moghaddam SM, Singer LG, Chaparro C, Azad S, Lazar N, Boutros PC, Keshavjee S, Rotstein C, Husain S. PMID: 22486950.
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    256. Integrated genome and transcriptome sequencing identifies a novel form of hybrid and aggressive prostate cancer. J Pathol. 2012 May; 227(1):53-61. Wu C, Wyatt AW, Lapuk AV, McPherson A, McConeghy BJ, Bell RH, Anderson S, Haegert A, Brahmbhatt S, Shukin R, Mo F, Li E, Fazli L, Hurtado-Coll A, Jones EC, Butterfield YS, Hach F, Hormozdiari F, Hajirasouliha I, Boutros PC, Bristow RG, Jones SJ, Hirst M, Marra MA, Maher CA, Chinnaiyan AM, Sahinalp SC, Gleave ME, Volik SV, Collins CC. PMID: 22294438; PMCID: PMC3768138.
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    259. Identification of a novel brain derived neurotrophic factor (BDNF)-inhibitory factor: regulation of BDNF by teneurin C-terminal associated peptide (TCAP)-1 in immortalized embryonic mouse hypothalamic cells. Regul Pept. 2012 Feb 10; 174(1-3):79-89. Ng T, Chand D, Song L, Al Chawaf A, Watson JD, Boutros PC, Belsham DD, Lovejoy DA. PMID: 22209827.
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    260. Unsupervised detection of genes of influence in lung cancer using biological networks. Bioinformatics. 2011 Nov 15; 27(22):3166-72. Goldenberg A, Mostafavi S, Quon G, Boutros PC, Morris QD. PMID: 21965819.
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    261. mRNA levels in control rat liver display strain-specific, hereditary, and AHR-dependent components. PLoS One. 2011; 6(7):e18337. Boutros PC, Moffat ID, Okey AB, Pohjanvirta R. PMID: 21760882; PMCID: PMC3132743.
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    262. A tree-based approach for motif discovery and sequence classification. Bioinformatics. 2011 Aug 01; 27(15):2054-61. Yan R, Boutros PC, Jurisica I. PMID: 21685048.
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    263. In-depth proteomics of ovarian cancer ascites: combining shotgun proteomics and selected reaction monitoring mass spectrometry. J Proteome Res. 2011 May 06; 10(5):2286-99. Elschenbroich S, Ignatchenko V, Clarke B, Kalloger SE, Boutros PC, Gramolini AO, Shaw P, Jurisica I, Kislinger T. PMID: 21491939.
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    264. Molecular markers of injury in kidney biopsy specimens of patients with lupus nephritis. J Mol Diagn. 2011 Mar; 13(2):143-51. Reich HN, Landolt-Marticorena C, Boutros PC, John R, Wither J, Fortin PR, Yang S, Scholey JW, Herzenberg AM. PMID: 21354048; PMCID: PMC3128621.
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    265. VennDiagram: a package for the generation of highly-customizable Venn and Euler diagrams in R. BMC Bioinformatics. 2011 Jan 26; 12:35. Chen H, Boutros PC. PMID: 21269502; PMCID: PMC3041657.
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    267. Differential interactions between statins and P-glycoprotein: implications for exploiting statins as anticancer agents. Int J Cancer. 2010 Dec 15; 127(12):2936-48. Goard CA, Mather RG, Vinepal B, Clendening JW, Martirosyan A, Boutros PC, Sharom FJ, Penn LZ. PMID: 21351272.
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    269. LTR: Linear Cross-Platform Integration of Microarray Data. Cancer Inform. 2010 Aug 27; 9:197-208. Boutros PC. PMID: 20838609; PMCID: PMC2935818.
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    277. Dioxin-dependent and dioxin-independent gene batteries: comparison of liver and kidney in AHR-null mice. Toxicol Sci. 2009 Nov; 112(1):245-56. Boutros PC, Bielefeld KA, Pohjanvirta R, Harper PA. PMID: 19759094; PMCID: PMC2769058.
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    278. Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model. Hum Mol Genet. 2009 Sep 01; 18(17):3227-43. Labrie V, Fukumura R, Rastogi A, Fick LJ, Wang W, Boutros PC, Kennedy JL, Semeralul MO, Lee FH, Baker GB, Belsham DD, Barger SW, Gondo Y, Wong AH, Roder JC. PMID: 19483194; PMCID: PMC2722985.
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    279. Robust global micro-RNA profiling with formalin-fixed paraffin-embedded breast cancer tissues. Lab Invest. 2009 May; 89(5):597-606. Hui AB, Shi W, Boutros PC, Miller N, Pintilie M, Fyles T, McCready D, Wong D, Gerster K, Waldron L, Jurisica I, Penn LZ, Liu FF. PMID: 19290006.
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    280. Prognostic gene signatures for non-small-cell lung cancer. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2824-8. Boutros PC, Lau SK, Pintilie M, Liu N, Shepherd FA, Der SD, Tsao MS, Penn LZ, Jurisica I. PMID: 19196983; PMCID: PMC2636731.
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    281. Optimization of experimental design parameters for high-throughput chromatin immunoprecipitation studies. Nucleic Acids Res. 2008 Dec; 36(21):e144. Ponzielli R, Boutros PC, Katz S, Stojanova A, Hanley AP, Khosravi F, Bros C, Jurisica I, Penn LZ. PMID: 18940864; PMCID: PMC2588500.
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