Isla P Garraway

Title(s)Professor, Urology
SchoolMedicine
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    Mechanisms of Prostate Cancer Metastasis
    NIH R01CA271750Sep 17, 2021 - Aug 31, 2026
    Role: Co-Principal Investigator
    B ELEMENT IN TATA LESS PROMOTERS
    NIH F31HG000117Apr 1, 1994
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. For us by us: Instituting mentorship models that credit minoritized medical faculty expertise and lived experience. Front Med (Lausanne). 2022; 9:966193. Bath EP, Brown K, Harris C, Guerrero A, Kozman D, Flippen CC, Garraway I, Watson K, Holly L, Godoy SM, Norris K, Wyatt G. PMID: 36341236; PMCID: PMC9634999.
      View in: PubMed   Mentions:
    2. The distinct impacts of race and genetic ancestry on health. Nat Med. 2022 05; 28(5):890-893. Rebbeck TR, Mahal B, Maxwell KN, Garraway IP, Yamoah K. PMID: 35534567.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    3. Evaluating Prostate-Specific Antigen Screening for Young African American Men With Cancer. J Natl Cancer Inst. 2022 04 11; 114(4):592-599. Qiao EM, Lynch JA, Lee KM, Kotha NV, Nalawade V, Voora RS, Qian AS, Nelson TJ, Yamoah K, Garraway IP, Stewart TF, Parsons JK, Rose BS. PMID: 34893859; PMCID: PMC9002290.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    4. The Movember Global Action Plan 1 (GAP1): Unique Prostate Cancer Tissue Microarray Resource. Cancer Epidemiol Biomarkers Prev. 2022 04 01; 31(4):715-727. Ouellet V, Erickson A, GAP1 UTMAs Contributing Investigators, Wiley K, Morrissey C, Berge V, Moreno CS, Tasken KA, Trudel D, True LD, Lewis MS, Svindland A, Ertunc O, Vidal ID, Osunkoya AO, Jones T, Bova GS, Lamminen T, Achtman AH, Buzza M, Kouspou MM, Bigler SA, Zhou X, Freedland SJ, Mes-Masson AM, Garraway IP, Trock BJ, Taimen P, Saad F, Mirtti T, Knudsen BS, De Marzo AM. PMID: 35131885; PMCID: PMC9381093.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Racial and Ethnic Disparities in Prostate Cancer Outcomes in the Veterans Affairs Health Care System. JAMA Netw Open. 2022 01 04; 5(1):e2144027. Yamoah K, Lee KM, Awasthi S, Alba PR, Perez C, Anglin-Foote TR, Robison B, Gao A, DuVall SL, Katsoulakis E, Wong YN, Markt SC, Rose BS, Burri R, Wang C, Aboiralor O, Fink AK, Nickols NG, Lynch JA, Garraway IP. PMID: 35040965; PMCID: PMC8767437.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    6. Comparison of Response to Definitive Radiotherapy for Localized Prostate Cancer in Black and White Men: A Meta-analysis. JAMA Netw Open. 2021 12 01; 4(12):e2139769. Ma TM, Romero T, Nickols NG, Rettig MB, Garraway IP, Roach M, Michalski JM, Pisansky TM, Lee WR, Jones CU, Rosenthal SA, Wang C, Hartman H, Nguyen PL, Feng FY, Boutros PC, Saigal C, Chamie K, Jackson WC, Morgan TM, Mehra R, Salami SS, Vince R, Schaeffer EM, Mahal BA, Dess RT, Steinberg ML, Elashoff D, Sandler HM, Spratt DE, Kishan AU. PMID: 34964855; PMCID: PMC8717118.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    7. The Clinical Cell-Cycle Risk (CCR) Score Is Associated With Metastasis After Radiation Therapy and Provides Guidance on When to Forgo Combined Androgen Deprivation Therapy With Dose-Escalated Radiation. Int J Radiat Oncol Biol Phys. 2022 05 01; 113(1):66-76. Tward J, Lenz L, Flake DD, Rajamani S, Yonover P, Olsson C, Kapoor DA, Mantz C, Liauw SL, Antic T, Fabrizio M, Salzstein D, Shore N, Albertson D, Henderson J, Lee SP, Gay HA, Michalski J, Hung A, Raben D, Garraway I, Lewis MS, Nguyen PL, Marshall DT, Brawer MK, Stone S, Cohen T. PMID: 34610388.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. Association of Health-Care System With Prostate Cancer-Specific Mortality in African American and Non-Hispanic White Men. J Natl Cancer Inst. 2021 10 01; 113(10):1343-1351. Klebaner D, Courtney PT, Garraway IP, Einck J, Kumar A, Martinez ME, McKay R, Murphy JD, Parada H, Sandhu A, Stewart T, Yamoah K, Rose BS. PMID: 33892497; PMCID: PMC8486332.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    9. Outcomes of Black men with prostate cancer treated with radiation therapy in the Veterans Health Administration. Cancer. 2021 02 01; 127(3):403-411. McKay RR, Sarkar RR, Kumar A, Einck JP, Garraway IP, Lynch JA, Mundt AJ, Murphy JD, Stewart TF, Yamoah K, Rose BS. PMID: 33036065.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    10. The Impact of 18F-DCFPyL PET-CT Imaging on Initial Staging, Radiation, and Systemic Therapy Treatment Recommendations for Veterans With Aggressive Prostate Cancer. Adv Radiat Oncol. 2020 Nov-Dec; 5(6):1364-1369. Parikh NR, Tsai S, Bennett C, Lewis M, Sadeghi A, Lorentz W, Cheung M, Garraway I, Aronson W, Kishan AU, Bahri S, Vahidi K, Calais J, Ishimitsu D, Rettig M, Nickols NG, Jafari L. PMID: 33305100; PMCID: PMC7718503.
      View in: PubMed   Mentions:
    11. Prostate cancer reactivates developmental epigenomic programs during metastatic progression. Nat Genet. 2020 08; 52(8):790-799. Pomerantz MM, Qiu X, Zhu Y, Takeda DY, Pan W, Baca SC, Gusev A, Korthauer KD, Severson TM, Ha G, Viswanathan SR, Seo JH, Nguyen HM, Zhang B, Pasaniuc B, Giambartolomei C, Alaiwi SA, Bell CA, O'Connor EP, Chabot MS, Stillman DR, Lis R, Font-Tello A, Li L, Cejas P, Bergman AM, Sanders J, van der Poel HG, Gayther SA, Lawrenson K, Fonseca MAS, Reddy J, Corona RI, Martovetsky G, Egan B, Choueiri T, Ellis L, Garraway IP, Lee GM, Corey E, Long HW, Zwart W, Freedman ML. PMID: 32690948.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    12. The Role of Opioids and Their Receptors in Urological Malignancy: A Review. J Urol. 2020 Dec; 204(6):1150-1159. Lec PM, Lenis AT, Golla V, Brisbane W, Shuch B, Garraway IP, Reiter RE, Chamie K. PMID: 32516030.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    13. Transcriptomic Heterogeneity of Gleason Grade Group 5 Prostate Cancer. Eur Urol. 2020 09; 78(3):327-332. Kishan AU, Romero T, Alshalalfa M, Liu Y, Tran PT, Nickols NG, Ye H, Sajed D, Rettig MB, Reiter RE, Garraway IP, Spratt DE, Freedland SJ, Zhao X, Li Z, Deek M, Livingstone J, Mahal BA, Nguyen PL, Feng FY, Den RB, Schaeffer EM, Lotan TL, Karnes RJ, Klein EA, Ross AE, Grogan T, Davicioni E, Elashoff D, Boutros PC, Weidhaas JB. PMID: 32461072; PMCID: PMC8954568.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    14. Chromosomal instability in untreated primary prostate cancer as an indicator of metastatic potential. BMC Cancer. 2020 May 07; 20(1):398. Miller ET, You S, Cadaneanu RM, Kim M, Yoon J, Liu ST, Li X, Kwan L, Hodge J, Quist MJ, Grasso CS, Lewis MS, Knudsen BS, Freeman MR, Garraway IP. PMID: 32380981; PMCID: PMC7204307.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    15. Asporin Restricts Mesenchymal Stromal Cell Differentiation, Alters the Tumor Microenvironment, and Drives Metastatic Progression. Cancer Res. 2019 07 15; 79(14):3636-3650. Hughes RM, Simons BW, Khan H, Miller R, Kugler V, Torquato S, Theodros D, Haffner MC, Lotan T, Huang J, Davicioni E, An SS, Riddle RC, Thorek DLJ, Garraway IP, Fertig EJ, Isaacs JT, Brennen WN, Park BH, Hurley PJ. PMID: 31123087; PMCID: PMC6734938.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    16. A Circulating Tumor Cell-RNA Assay for Assessment of Androgen Receptor Signaling Inhibitor Sensitivity in Metastatic Castration-Resistant Prostate Cancer. Theranostics. 2019; 9(10):2812-2826. Jan YJ, Yoon J, Chen JF, Teng PC, Yao N, Cheng S, Lozano A, Chu GCY, Chung H, Lu YT, Chen PJ, Wang JJ, Lee YT, Kim M, Zhu Y, Knudsen BS, Feng FY, Garraway IP, Gao AC, Chung LWK, Freeman MR, You S, Tseng HR, Posadas EM. PMID: 31244925; PMCID: PMC6568173.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    17. Systemic and tumor-directed therapy for oligometastatic prostate cancer: study protocol for a phase II trial for veterans with de novo oligometastatic disease. BMC Cancer. 2019 Apr 01; 19(1):291. Parikh NR, Huiza C, Patel JS, Tsai S, Kalpage N, Thein M, Pitcher S, Lee SP, Inouye WS, Jordan ML, Sanati H, Jafari L, Bennett CJ, Gin GE, Kishan AU, Reiter RE, Lewis M, Sadeghi A, Aronson WJ, Garraway IP, Rettig MB, Nickols NG. PMID: 30935383; PMCID: PMC6444674.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCTClinical Trials
    18. ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis. Nat Med. 2018 12; 24(12):1887-1898. Rotinen M, You S, Yang J, Coetzee SG, Reis-Sobreiro M, Huang WC, Huang F, Pan X, Y??ez A, Hazelett DJ, Chu CY, Steadman K, Morrissey CM, Nelson PS, Corey E, Chung LWK, Freedland SJ, Di Vizio D, Garraway IP, Murali R, Knudsen BS, Freeman MR. PMID: 30478421; PMCID: PMC6614557.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    19. Clonal diversity revealed by morphoproteomic and copy number profiles of single prostate cancer cells at diagnosis. Converg Sci Phys Oncol. 2018 Mar; 4(1). Malihi PD, Morikado M, Welter L, Liu ST, Miller ET, Cadaneanu RM, Knudsen BS, Lewis MS, Carlsson A, Velasco CR, Kolatkar A, Rodriguez-Lee M, Garraway IP, Hicks J, Kuhn P. PMID: 32670616; PMCID: PMC7363158.
      View in: PubMed   Mentions: 14  
    20. Mesenchymal stem cell infiltration during neoplastic transformation of the human prostate. Oncotarget. 2017 Jul 18; 8(29):46710-46727. Brennen WN, Zhang B, Kulac I, Kisteman LN, Antony L, Wang H, Meeker AK, De Marzo AM, Garraway IP, Denmeade SR, Isaacs JT. PMID: 28493842; PMCID: PMC5564518.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    21. Impact of treatment on progression to castration-resistance, metastases, and death in men with localized high-grade prostate cancer. Cancer Med. 2017 01; 6(1):163-172. Miller ET, Chamie K, Kwan L, Lewis MS, Knudsen BS, Garraway IP. PMID: 27997745; PMCID: PMC5269571.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    22. Keratin 13 expression reprograms bone and brain metastases of human prostate cancer cells. Oncotarget. 2016 Dec 20; 7(51):84645-84657. Li Q, Yin L, Jones LW, Chu GC, Wu JB, Huang JM, Li Q, You S, Kim J, Lu YT, Mrdenovic S, Wang R, Freeman MR, Garraway I, Lewis MS, Chung LW, Zhau HE. PMID: 27835867; PMCID: PMC5356688.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    23. Keratin 13 Is Enriched in Prostate Tubule-Initiating Cells and May Identify Primary Prostate Tumors that Metastasize to the Bone. PLoS One. 2016; 11(10):e0163232. Liu S, Cadaneanu RM, Zhang B, Huo L, Lai K, Li X, Galet C, Grogan TR, Elashoff D, Freedland SJ, Rettig M, Aronson WJ, Knudsen BS, Lewis MS, Garraway IP. PMID: 27711225; PMCID: PMC5053503.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    24. Integrated Classification of Prostate Cancer Reveals a Novel Luminal Subtype with Poor Outcome. Cancer Res. 2016 09 01; 76(17):4948-58. You S, Knudsen BS, Erho N, Alshalalfa M, Takhar M, Al-Deen Ashab H, Davicioni E, Karnes RJ, Klein EA, Den RB, Ross AE, Schaeffer EM, Garraway IP, Kim J, Freeman MR. PMID: 27302169; PMCID: PMC5047668.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansCells
    25. Multidisciplinary intervention of early, lethal metastatic prostate cancer: Report from the 2015 Coffey-Holden Prostate Cancer Academy Meeting. Prostate. 2016 Feb; 76(2):125-39. Miyahira AK, Lang JM, Den RB, Garraway IP, Lotan TL, Ross AE, Stoyanova T, Cho SY, Simons JW, Pienta KJ, Soule HR. PMID: 26477609; PMCID: PMC5830186.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    26. YAP1 and AR interactions contribute to the switch from androgen-dependent to castration-resistant growth in prostate cancer. Nat Commun. 2015 Sep 01; 6:8126. Kuser-Abali G, Alptekin A, Lewis M, Garraway IP, Cinar B. PMID: 28230103; PMCID: PMC5327734.
      View in: PubMed   Mentions: 48     Fields:    
    27. Differential gene expression profiling of functionally and developmentally distinct human prostate epithelial populations. Prostate. 2015 May; 75(7):764-76. Liu H, Cadaneanu RM, Lai K, Zhang B, Huo L, An DS, Li X, Lewis MS, Garraway IP. PMID: 25663004; PMCID: PMC4409819.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    28. Targeting the RANKL pathway: putting the brakes on prostate cancer progression in bone. J Clin Oncol. 2013 Oct 20; 31(30):3838-40. Garraway IP. PMID: 24043735.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    29. Stromal modulation of bladder cancer-initiating cells in a subcutaneous tumor model. Am J Cancer Res. 2012; 2(6):745-51. Peek EM, Li DR, Zhang H, Kim HP, Zhang B, Garraway IP, Chin AI. PMID: 23226620; PMCID: PMC3512189.
      View in: PubMed   Mentions: 7  
    30. Secreted Hsp90 is a novel regulator of the epithelial to mesenchymal transition (EMT) in prostate cancer. J Biol Chem. 2012 Nov 02; 287(45):37732-44. Hance MW, Dole K, Gopal U, Bohonowych JE, Jezierska-Drutel A, Neumann CA, Liu H, Garraway IP, Isaacs JS. PMID: 22989880; PMCID: PMC3488049.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    31. Identification of CD166 as a surface marker for enriching prostate stem/progenitor and cancer initiating cells. PLoS One. 2012; 7(8):e42564. Jiao J, Hindoyan A, Wang S, Tran LM, Goldstein AS, Lawson D, Chen D, Li Y, Guo C, Zhang B, Fazli L, Gleave M, Witte ON, Garraway IP, Wu H. PMID: 22880034; PMCID: PMC3411798.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    32. Will identification of a prostate cancer stem cell lead to its cure? Urol Oncol. 2012 Jul-Aug; 30(4):351-2. Garraway IP. PMID: 22930822.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    33. Epcam, CD44, and CD49f distinguish sphere-forming human prostate basal cells from a subpopulation with predominant tubule initiation capability. PLoS One. 2012; 7(4):e34219. Guo C, Liu H, Zhang BH, Cadaneanu RM, Mayle AM, Garraway IP. PMID: 22514625; PMCID: PMC3326009.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    34. Isolation and characterization of human prostate stem/progenitor cells. Methods Mol Biol. 2012; 879:315-26. Guo C, Zhang B, Garraway IP. PMID: 22610567.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    35. Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth. Cancer Cell. 2011 Jun 14; 19(6):792-804. Mulholland DJ, Tran LM, Li Y, Cai H, Morim A, Wang S, Plaisier S, Garraway IP, Huang J, Graeber TG, Wu H. PMID: 21620777; PMCID: PMC3157296.
      View in: PubMed   Mentions: 287     Fields:    Translation:HumansAnimalsCells
    36. Identification of a cell of origin for human prostate cancer. Science. 2010 Jul 30; 329(5991):568-71. Goldstein AS, Huang J, Guo C, Garraway IP, Witte ON. PMID: 20671189; PMCID: PMC2917982.
      View in: PubMed   Mentions: 315     Fields:    Translation:HumansAnimalsCells
    37. Absent CD44v6 expression is an independent predictor of poor urothelial bladder cancer outcome. J Urol. 2010 Jun; 183(6):2403-8. Klatte T, Seligson DB, Rao JY, Yu H, de Martino M, Garraway I, Wong SG, Belldegrun AS, Pantuck AJ. PMID: 20403620.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    38. Human prostate sphere-forming cells represent a subset of basal epithelial cells capable of glandular regeneration in vivo. Prostate. 2010 Apr 01; 70(5):491-501. Garraway IP, Sun W, Tran CP, Perner S, Zhang B, Goldstein AS, Hahm SA, Haider M, Head CS, Reiter RE, Rubin MA, Witte ON. PMID: 19938015; PMCID: PMC2885946.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansCells
    39. Trop2 identifies a subpopulation of murine and human prostate basal cells with stem cell characteristics. Proc Natl Acad Sci U S A. 2008 Dec 30; 105(52):20882-7. Goldstein AS, Lawson DA, Cheng D, Sun W, Garraway IP, Witte ON. PMID: 19088204; PMCID: PMC2603432.
      View in: PubMed   Mentions: 193     Fields:    Translation:HumansAnimalsCells
    40. Phospho-Akt pathway activation and inhibition depends on N-cadherin or phospho-EGFR expression in invasive human bladder cancer cell lines. Urol Oncol. 2010 Mar-Apr; 28(2):180-8. Wallerand H, Cai Y, Wainberg ZA, Garraway I, Lascombe I, Nicolle G, Thiery JP, Bittard H, Radvanyi F, Reiter RR. PMID: 19070520.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    41. Epithelial stem cells of the prostate and their role in cancer progression. Cold Spring Harb Symp Quant Biol. 2008; 73:491-502. Lukacs RU, Lawson DA, Xin L, Zong Y, Garraway I, Goldstein AS, Memarzadeh S, Witte ON. PMID: 19022743.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    42. Trefoil factor 3 is overexpressed in human prostate cancer. Prostate. 2004 Nov 01; 61(3):209-14. Garraway IP, Seligson D, Said J, Horvath S, Reiter RE. PMID: 15368472.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    43. Current treatment options for penile fractures. Rev Urol. 2004; 6(3):114-20. Jack GS, Garraway I, Reznichek R, Rajfer J. PMID: 16985591; PMCID: PMC1472832.
      View in: PubMed   Mentions: 25  
    44. Case scenario: 26-year-old male with right scrotal pain and swelling. Rev Urol. 2002; 4(1):43. Garraway I, Liao J, Rajfer J. PMID: 16985652; PMCID: PMC1475959.
      View in: PubMed   Mentions:
    45. Down-regulation of TDT transcription in CD4(+)CD8(+) thymocytes by Ikaros proteins in direct competition with an Ets activator. Genes Dev. 2001 Jul 15; 15(14):1817-32. Trinh LA, Ferrini R, Cobb BS, Weinmann AS, Hahm K, Ernst P, Garraway IP, Merkenschlager M, Smale ST. PMID: 11459831; PMCID: PMC312741.
      View in: PubMed   Mentions: 38     Fields:    Translation:Cells
    46. Transcription of the lymphocyte-specific terminal deoxynucleotidyltransferase gene requires a specific core promoter structure. Proc Natl Acad Sci U S A. 1996 Apr 30; 93(9):4336-41. Garraway IP, Semple K, Smale ST. PMID: 8633066; PMCID: PMC39537.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
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