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Tumor-derived biomarkers predict efficacy of B7H3 antibody-drug conjugate treatment in metastatic prostate cancer models. J Clin Invest. 2023 Sep 19.
Agarwal S, Fang L, McGowen K, Yin J, Bowman J, Ku AT, Alilin AN, Corey E, Roudier MP, True LD, Dumpit RF, Coleman I, Lee JK, Nelson PS, Capaldo BJ, Mariani A, Hoover CE, Senatorov IS, Beshiri M, Sowalsky AG, Hurt EM, Kelly K. PMID: 37725435.
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PubMed Mentions:
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LSD1 promotes prostate cancer reprogramming by repressing TP53 signaling independently of its demethylase function. JCI Insight. 2023 Aug 08; 8(15).
Kumaraswamy A, Duan Z, Flores D, Zhang C, Sehrawat A, Hu YM, Swaim OA, Rodansky E, Storck WK, Kuleape JA, Bedi K, Mannan R, Wang XM, Udager A, Ravikumar V, Bankhead A, Coleman I, Lee JK, Morrissey C, Nelson PS, Chinnaiyan AM, Rao A, Xia Z, Yates JA, Alumkal JJ. PMID: 37440313; PMCID: PMC10445684.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting. Nat Commun. 2023 Aug 07; 14(1):4737.
Lee EHJ, Murad JP, Christian L, Gibson J, Yamaguchi Y, Cullen C, Gumber D, Park AK, Young C, Monroy I, Yang J, Stern LA, Adkins LN, Dhapola G, Gittins B, Chang WC, Martinez C, Woo Y, Cristea M, Rodriguez-Rodriguez L, Ishihara J, Lee JK, Forman SJ, Wang LD, Priceman SJ. PMID: 37550294; PMCID: PMC10406808.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Androgen-regulated stromal complement component 7 (C7) suppresses prostate cancer growth. Oncogene. 2023 Aug; 42(32):2428-2438.
Zhou Z, Jia D, Kwon O, Li S, Sun H, Roudier MP, Lin DW, True L, Morrissey C, Creighton CJ, Lee JK, Xin L. PMID: 37400528.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
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Metastatic Bladder Cancer Expression and Subcellular Localization of Nectin-4 and Trop-2 in Variant Histology: A Rapid Autopsy Study. Clin Genitourin Cancer. 2023 May 25.
Ghali F, Vakar-Lopez F, Roudier MP, Garcia J, Arora S, Cheng HH, Schweizer MT, Haffner MC, Lee JK, Yu EY, Grivas P, Montgomery B, Hsieh AC, Wright JL, Lam HM. PMID: 37344281.
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PubMed Mentions: Fields:
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Large libraries of single-chain trimer peptide-MHCs enable antigen-specific CD8+ T cell discovery and analysis. Commun Biol. 2023 May 16; 6(1):528.
Chour W, Choi J, Xie J, Chaffee ME, Schmitt TM, Finton K, DeLucia DC, Xu AM, Su Y, Chen DG, Zhang R, Yuan D, Hong S, Ng AHC, Butler JZ, Edmark RA, Jones LC, Murray KM, Peng S, Li G, Strong RK, Lee JK, Goldman JD, Greenberg PD, Heath JR. PMID: 37193826; PMCID: PMC10186326.
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PubMed Mentions: Translation:
HumansCells
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Expanding the landscape of TCR gene therapy targeting MAGE. Mol Ther Oncolytics. 2023 Jun 15; 29:59-60.
Mao Z, Lee JK. PMID: 37215387; PMCID: PMC10195836.
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Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression. Cancer Cell. 2023 05 08; 41(5):853-870.e13.
Jana S, Brahma S, Arora S, Wladyka CL, Hoang P, Blinka S, Hough R, Horn JL, Liu Y, Wang LJ, Depeille P, Smith E, Montgomery RB, Lee JK, Haffner MC, Vakar-Lopez F, Grivas P, Wright JL, Lam HM, Black PC, Roose JP, Ryazanov AG, Subramaniam AR, Henikoff S, Hsieh AC. PMID: 37084735; PMCID: PMC10208629.
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Translation:
HumansCells
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Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations. bioRxiv. 2023 Apr 14.
Li S, Wong A, Sun H, Bhatia V, Javier G, Jana S, Montgomery RB, Wright JL, Lam HM, Hsieh AC, Faltas BM, Haffner MC, Lee JK. PMID: 37609344; PMCID: PMC10441433.
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Targeting advanced prostate cancer with STEAP1 chimeric antigen receptor T cell and tumor-localized IL-12 immunotherapy. Nat Commun. 2023 Apr 11; 14(1):2041.
Bhatia V, Kamat NV, Pariva TE, Wu LT, Tsao A, Sasaki K, Sun H, Javier G, Nutt S, Coleman I, Hitchcock L, Zhang A, Rudoy D, Gulati R, Patel RA, Roudier MP, True LD, Srivastava S, Morrissey CM, Haffner MC, Nelson PS, Priceman SJ, Ishihara J, Lee JK. PMID: 37041154; PMCID: PMC10090190.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Reversible epigenetic alterations mediate PSMA expression heterogeneity in advanced metastatic prostate cancer. JCI Insight. 2023 04 10; 8(7).
Sayar E, Patel RA, Coleman IM, Roudier MP, Zhang A, Mustafi P, Low JY, Hanratty B, Ang LS, Bhatia V, Adil M, Bakbak H, Quigley DA, Schweizer MT, Hawley JE, Kollath L, True LD, Feng FY, Bander NH, Corey E, Lee JK, Morrissey C, Gulati R, Nelson PS, Haffner MC. PMID: 36821396; PMCID: PMC10132157.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Entropic analysis of antigen-specific CDR3 domains identifies essential binding motifs shared by CDR3s with different antigen specificities. Cell Syst. 2023 Apr 19; 14(4):273-284.e5.
Xu AM, Chour W, DeLucia DC, Su Y, Pavlovitch-Bedzyk AJ, Ng R, Rasheed Y, Davis MM, Lee JK, Heath JR. PMID: 37001518; PMCID: PMC10355346.
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PubMed Mentions: Fields:
Translation:
Cells
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Internet-Based Germline Genetic Testing for Men With Metastatic Prostate Cancer. JCO Precis Oncol. 2023 Jan; 7:e2200104.
Cheng HH, Sokolova AO, Gulati R, Bowen D, Knerr SA, Klemfuss N, Grivas P, Hsieh A, Lee JK, Schweizer MT, Yezefski T, Zhou A, Yu EY, Nelson PS, Montgomery B. PMID: 36623239; PMCID: PMC9928882.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Genomic Characterization of Prostatic Basal Cell Carcinoma. Am J Pathol. 2023 Jan; 193(1):4-10.
Low JY, Ko M, Hanratty B, Patel RA, Bhamidipati A, Heaphy CM, Sayar E, Lee JK, Li S, De Marzo AM, Nelson WG, Gupta A, Yegnasubramanian S, Ha G, Epstein JI, Haffner MC. PMID: 36309102; PMCID: PMC9768679.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Physical and in silico immunopeptidomic profiling of a cancer antigen prostatic acid phosphatase reveals targets enabling TCR isolation. Proc Natl Acad Sci U S A. 2022 08 02; 119(31):e2203410119.
Mao Z, Nesterenko PA, McLaughlin J, Deng W, Burton Sojo G, Cheng D, Noguchi M, Chour W, DeLucia DC, Finton KA, Qin Y, Obusan MB, Tran W, Wang L, Bangayan NJ, Ta L, Chen CC, Seet CS, Crooks GM, Phillips JW, Heath JR, Strong RK, Lee JK, Wohlschlegel JA, Witte ON. PMID: 35878026; PMCID: PMC9351518.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Comprehensive assessment of anaplastic lymphoma kinase in localized and metastatic prostate cancer reveals targetable alterations. Cancer Res Commun. 2022 May; 2(5):277-285.
Patel RA, Coleman I, Roudier MP, Konnick EQ, Hanratty B, Dumpit R, Lucas JM, Ang LS, Low JY, Tretiakova MS, Ha G, Lee JK, True LD, De Marzo AM, Nelson PS, Morrissey C, Pritchard CC, Haffner MC. PMID: 36337169; PMCID: PMC9635400.
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PubMed Mentions:
1 Translation:
Humans
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Development of Cancer Immunotherapies. Cancer Treat Res. 2022; 183:1-48.
DeLucia DC, Lee JK. PMID: 35551655.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Nat Commun. 2021 Aug 09; 12(1):4789.
Vichas A, Riley AK, Nkinsi NT, Kamlapurkar S, Parrish PCR, Lo A, Duke F, Chen J, Fung I, Watson J, Rees M, Gabel AM, Thomas JD, Bradley RK, Lee JK, Hatch EM, Baine MK, Rekhtman N, Ladanyi M, Piccioni F, Berger AH. PMID: 34373451; PMCID: PMC8352964.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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RNA Splicing Factors SRRM3 and SRRM4 Distinguish Molecular Phenotypes of Castration-Resistant Neuroendocrine Prostate Cancer. Cancer Res. 2021 Sep 15; 81(18):4736-4750.
Labrecque MP, Brown LG, Coleman IM, Lakely B, Brady NJ, Lee JK, Nguyen HM, Li D, Hanratty B, Haffner MC, Rickman DS, True LD, Lin DW, Lam HM, Alumkal JJ, Corey E, Nelson PS, Morrissey C. PMID: 34312180; PMCID: PMC8448969.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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BiTE-ing into Prostate Cancer with Bispecific T-cell Engagers. Clin Cancer Res. 2021 May 15; 27(10):2675-2677.
Kamat NV, Yu EY, Lee JK. PMID: 33707179; PMCID: PMC8127346.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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A bladder cancer patient-derived xenograft displays aggressive growth dynamics in vivo and in organoid culture. Sci Rep. 2021 Feb 25; 11(1):4609.
Cai EY, Garcia J, Liu Y, Vakar-Lopez F, Arora S, Nguyen HM, Lakely B, Brown L, Wong A, Montgomery B, Lee JK, Corey E, Wright JL, Hsieh AC, Lam HM. PMID: 33633154; PMCID: PMC7907272.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimals
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Patterns and timing of perioperative blood transfusion and association with outcomes after radical cystectomy. Urol Oncol. 2021 Aug; 39(8):496.e1-496.e8.
Diamantopoulos LN, Sekar RR, Holt SK, Khaki AR, Miller NJ, Gadzinski A, Nyame YA, Vakar-Lopez F, Tretiakova MS, Psutka SP, Gore JL, Lin DW, Schade GR, Hsieh AC, Lee JK, Yezefski T, Schweizer MT, Cheng HH, Yu EY, True LD, Montgomery RB, Grivas P, Wright JL. PMID: 33551249.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Regulation of CEACAM5 and Therapeutic Efficacy of an Anti-CEACAM5-SN38 Antibody-drug Conjugate in Neuroendocrine Prostate Cancer. Clin Cancer Res. 2021 Feb 01; 27(3):759-774.
DeLucia DC, Cardillo TM, Ang L, Labrecque MP, Zhang A, Hopkins JE, De Sarkar N, Coleman I, da Costa RMG, Corey E, True LD, Haffner MC, Schweizer MT, Morrissey C, Nelson PS, Lee JK. PMID: 33199493; PMCID: PMC7854497.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Response to Neoadjuvant Chemotherapy and Survival in Micropapillary Urothelial Carcinoma: Data From a Tertiary Referral Center and the Surveillance, Epidemiology, and End Results (SEER) Program. Clin Genitourin Cancer. 2021 Apr; 19(2):144-154.
Diamantopoulos LN, Holt SK, Khaki AR, Sekar RR, Gadzinski A, Nyame YA, Vakar-Lopez F, Tretiakova MS, Psutka SP, Gore JL, Lin DW, Schade GR, Hsieh AC, Lee JK, Yezefski T, Schweizer MT, Cheng HH, Yu EY, True LD, Montgomery RB, Grivas P, Wright JL. PMID: 33160889; PMCID: PMC8044249.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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De novo induction of lineage plasticity from human prostate luminal epithelial cells by activated AKT1 and c-Myc. Oncogene. 2020 Nov; 39(48):7142-7151.
Kwon OJ, Zhang L, Jia D, Zhou Z, Li Z, Haffner M, Lee JK, True L, Morrissey C, Xin L. PMID: 33009488; PMCID: PMC7704645.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Targeting RET Kinase in Neuroendocrine Prostate Cancer. Mol Cancer Res. 2020 08; 18(8):1176-1188.
VanDeusen HR, Ramroop JR, Morel KL, Bae SY, Sheahan AV, Sychev Z, Lau NA, Cheng LC, Tan VM, Li Z, Petersen A, Lee JK, Park JW, Yang R, Hwang JH, Coleman I, Witte ON, Morrissey C, Corey E, Nelson PS, Ellis L, Drake JM. PMID: 32461304; PMCID: PMC7415621.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Plasmacytoid urothelial carcinoma: response to chemotherapy and oncologic outcomes. Bladder Cancer. 2020; 6(1):71-81.
Diamantopoulos LN, Khaki AR, Grivas P, Gore JL, Schade GR, Hsieh AC, Lee JK, Yezefski T, Yu EY, Schweizer MT, Cheng HH, Psutka SP, Lin DW, Tretiakova MS, Vakar-Lopez F, Montgomery RB, Wright JL. PMID: 34109262; PMCID: PMC8186525.
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PubMed Mentions:
6
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Identification of Cell Surface Targets for CAR T Cell Immunotherapy. Methods Mol Biol. 2020; 2097:45-54.
DeLucia DC, Lee JK. PMID: 31776917.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Identification of Therapeutic Vulnerabilities in Small-cell Neuroendocrine Prostate Cancer. Clin Cancer Res. 2020 Apr 01; 26(7):1667-1677.
Corella AN, Cabiliza Ordonio MVA, Coleman I, Lucas JM, Kaipainen A, Nguyen HM, Sondheim D, Brown LG, True LD, Lee JK, MacPherson D, Nghiem P, Gulati R, Morrissey C, Corey E, Nelson PS. PMID: 31806643; PMCID: PMC7124974.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Targeting cellular heterogeneity with CXCR2 blockade for the treatment of therapy-resistant prostate cancer. Sci Transl Med. 2019 12 04; 11(521).
Li Y, He Y, Butler W, Xu L, Chang Y, Lei K, Zhang H, Zhou Y, Gao AC, Zhang Q, Taylor DG, Cheng D, Farber-Katz S, Karam R, Landrith T, Li B, Wu S, Hsuan V, Yang Q, Hu H, Chen X, Flowers M, McCall SJ, Lee JK, Smith BA, Park JW, Goldstein AS, Witte ON, Wang Q, Rettig MB, Armstrong AJ, Cheng Q, Huang J. PMID: 31801883; PMCID: PMC7238624.
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PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
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PEG10 Promoter-Driven Expression of Reporter Genes Enables Molecular Imaging of Lethal Prostate Cancer. Cancer Res. 2019 Nov 01; 79(21):5668-5680.
Shapovalova M, Lee JK, Li Y, Vander Griend DJ, Coleman IM, Nelson PS, Dehm SM, LeBeau AM. PMID: 31530569; PMCID: PMC6825593.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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The Role of Lineage Plasticity in Prostate Cancer Therapy Resistance. Clin Cancer Res. 2019 12 01; 25(23):6916-6924.
Beltran H, Hruszkewycz A, Scher HI, Hildesheim J, Isaacs J, Yu EY, Kelly K, Lin D, Dicker A, Arnold J, Hecht T, Wicha M, Sears R, Rowley D, White R, Gulley JL, Lee J, Diaz Meco M, Small EJ, Shen M, Knudsen K, Goodrich DW, Lotan T, Zoubeidi A, Sawyers CL, Rudin CM, Loda M, Thompson T, Rubin MA, Tawab-Amiri A, Dahut W, Nelson PS. PMID: 31363002; PMCID: PMC6891154.
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PubMed Mentions:
132 Fields:
Translation:
Humans
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Genomic distinctions between metastatic lower and upper tract urothelial carcinoma revealed through rapid autopsy. JCI Insight. 2019 May 30; 5(13).
Winters BR, De Sarkar N, Arora S, Bolouri H, Jana S, Vakar-Lopez F, Cheng HH, Schweizer MT, Yu EY, Grivas P, Lee JK, Kollath L, Holt SK, McFerrin L, Ha G, Nelson PS, Montgomery RB, Wright JL, Lam HM, Hsieh AC. PMID: 31145100; PMCID: PMC6629128.
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PubMed Mentions:
12 Fields:
Translation:
Humans
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Precision Medicine-Enabled Cancer Immunotherapy. Cancer Treat Res. 2019; 178:189-205.
Lee JK, Priceman SJ. PMID: 31209846.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage. Science. 2018 10 05; 362(6410):91-95.
Park JW, Lee JK, Sheu KM, Wang L, Balanis NG, Nguyen K, Smith BA, Cheng C, Tsai BL, Cheng D, Huang J, Kurdistani SK, Graeber TG, Witte ON. PMID: 30287662; PMCID: PMC6414229.
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PubMed Mentions:
120 Fields:
Translation:
HumansCells
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Systemic surfaceome profiling identifies target antigens for immune-based therapy in subtypes of advanced prostate cancer. Proc Natl Acad Sci U S A. 2018 05 08; 115(19):E4473-E4482.
Lee JK, Bangayan NJ, Chai T, Smith BA, Pariva TE, Yun S, Vashisht A, Zhang Q, Park JW, Corey E, Huang J, Graeber TG, Wohlschlegel J, Witte ON. PMID: 29686080; PMCID: PMC5949005.
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PubMed Mentions:
57 Fields:
Translation:
HumansCells
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FOXA2 is a sensitive and specific marker for small cell neuroendocrine carcinoma of the prostate. Mod Pathol. 2017 09; 30(9):1262-1272.
Park JW, Lee JK, Witte ON, Huang J. PMID: 28621319; PMCID: PMC6330177.
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PubMed Mentions:
42 Fields:
Translation:
HumansAnimalsCells
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Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2016 10 18; 113(42):E6457-E6466.
Stoyanova T, Riedinger M, Lin S, Faltermeier CM, Smith BA, Zhang KX, Going CC, Goldstein AS, Lee JK, Drake JM, Rice MA, Hsu EC, Nowroozizadeh B, Castor B, Orellana SY, Blum SM, Cheng D, Pienta KJ, Reiter RE, Pitteri SJ, Huang J, Witte ON. PMID: 27694579; PMCID: PMC5081658.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
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Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer. Cell. 2016 Aug 11; 166(4):1041-1054.
Drake JM, Paull EO, Graham NA, Lee JK, Smith BA, Titz B, Stoyanova T, Faltermeier CM, Uzunangelov V, Carlin DE, Fleming DT, Wong CK, Newton Y, Sudha S, Vashisht AA, Huang J, Wohlschlegel JA, Graeber TG, Witte ON, Stuart JM. PMID: 27499020; PMCID: PMC4985183.
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PubMed Mentions:
103 Fields:
Translation:
HumansCells
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Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay. Proc Natl Acad Sci U S A. 2016 Apr 19; 113(16):4482-7.
Park JW, Lee JK, Phillips JW, Huang P, Cheng D, Huang J, Witte ON. PMID: 27044116; PMCID: PMC4843433.
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PubMed Mentions:
55 Fields:
Translation:
HumansAnimalsCells
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N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells. Cancer Cell. 2016 Apr 11; 29(4):536-547.
Lee JK, Phillips JW, Smith BA, Park JW, Stoyanova T, McCaffrey EF, Baertsch R, Sokolov A, Meyerowitz JG, Mathis C, Cheng D, Stuart JM, Shokat KM, Gustafson WC, Huang J, Witte ON. PMID: 27050099; PMCID: PMC4829466.
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PubMed Mentions:
187 Fields:
Translation:
HumansAnimalsCells
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Clinical targeting of mutated and wild-type protein tyrosine kinases in cancer. Mol Cell Biol. 2014 May; 34(10):1722-32.
Drake JM, Lee JK, Witte ON. PMID: 24567371; PMCID: PMC4019040.
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PubMed Mentions:
36 Fields:
Translation:
HumansAnimals
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Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets. Proc Natl Acad Sci U S A. 2013 Dec 03; 110(49):E4762-9.
Drake JM, Graham NA, Lee JK, Stoyanova T, Faltermeier CM, Sud S, Titz B, Huang J, Pienta KJ, Graeber TG, Witte ON. PMID: 24248375; PMCID: PMC3856845.
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PubMed Mentions:
67 Fields:
Translation:
HumansCells
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Blastic plasmacytoid dendritic cell neoplasm. Clin Adv Hematol Oncol. 2012 Jan; 10(1):60-2.
Lee JK, Schiller G. PMID: 22398811.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells