John Kyung Lee

Title(s)Associate Professor-in-residence, Medicine
SchoolMedicine
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    Other Positions
    Title(s)Associate Professor-in-residence, Urology

    Title(s)Associate Professor-in-residence, Molecular and Medical Pharmacology


    Collapse Biography 
    Collapse education and training
    Harvard University, Cambridge, MAAB06/2001Biochemical Sciences
    Geisel School of Medicine at Dartmouth, Hanover, NHMD06/2006Medicine
    Boston Medical Center, Boston, MA06/2009Internal Medicine
    David Geffen School of Medicine at UCLA, Los Angeles, CA06/2013Hematology/Oncology
    UCLA Molecular Biology Institute, Los Angeles, CAPhD06/2016Molecular Biology
    Collapse awards and honors
    2024CureSearch for Children's Cancer Acceleration Initiative Award
    2024Elected Member, American Society for Clinical Investigation (ASCI)
    2022Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation Medical Research Award
    2021NCI Experimental Therapeutics (NExT) Program Top Tier Application and Partnership
    2021NIH Director's New Innovator (DP2) Award
    2021Atomwise Artificial Intelligence Molecular Screen (AIMS) Award
    2021Robert & Susan Hollander Foundation Research Award
    2021American Urological Association Early-Career investigators Showcase, Third Place
    2021Bladder Cancer Advocacy Network (BCAN) Bladder Cancer Research Innovation Award
    2020Society for Basic Urologic Research (SBUR) Young Investigator Award
    2020American Society for Clinical Investigation (ASCI) Young Physician-Scientist Award
    2019Society for Basic Urologic Research (SBUR) Eula and Donald S. Coffey Innovative Research Award
    2019Movember Foundation-Prostate Cancer Foundation (PCF) Challenge Award
    2019Safeway Early Career Award in Cancer Research
    2015Lori Milken-Prostate Cancer Foundation (PCF) Young Investigator Award

    Collapse Overview 
    Collapse overview
    John K. Lee is a physician-scientist and Associate Professor-in-Residence in the Division of Hematology/Oncology, Department of Medicine and the Institute for Urologic Oncology, Department of Urology at the David Geffen School of Medicine at UCLA. He received an A.B. with highest honors in Biochemical Sciences at Harvard University and an M.D. at the Geisel School of Medicine at Dartmouth during which he participated in the HHMI-NIH Research Scholars Program. Dr. Lee completed his clinical training in internal medicine at Boston Medical Center and Specialty Training and Advanced Research (STAR) fellowship in medical oncology at UCLA where he obtained a Ph.D. from the Molecular Biology Institute under the mentorship of Dr. Owen Witte. He specializes in genitourinary oncology, specifically caring for patients with advanced prostate and bladder cancer. Dr. Lee also leads a federally funded basic and translational research laboratory within the UCLA Jonsson Comprehensive Cancer Center focused on untangling diverse genotype-phenotype relationships in cancer and developing new immune-based strategies to effectively treat prostate and bladder cancer.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Defined cellular reprogramming of androgen receptor-active prostate cancer to neuroendocrine prostate cancer. bioRxiv. 2025 Mar 07. Li S, Song K, Sun H, Tao Y, Huang A, Bhatia V, Hanratty B, Patel RA, Long HW, Morrissey C, Haffner MC, Nelson PS, Graeber TG, Lee JK. PMID: 40027790; PMCID: PMC11870442.
      View in: PubMed   Mentions:
    2. Advances in CAR T cell therapy: antigen selection, modifications, and current trials for solid tumors. Front Immunol. 2024; 15:1489827. Khan SH, Choi Y, Veena M, Lee JK, Shin DS. PMID: 39835140; PMCID: PMC11743624.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    3. PGC-1α drives small cell neuroendocrine cancer progression toward an ASCL1-expressing subtype with increased mitochondrial capacity. Proc Natl Acad Sci U S A. 2024 Dec 03; 121(49):e2416882121. Varuzhanyan G, Chen CC, Freeland J, He T, Tran W, Song K, Wang L, Cheng D, Xu S, Dibernardo GA, Esedebe FN, Bhatia V, Han M, Abt ER, Park JW, Memarzadeh S, Shackelford DB, Lee JK, Graeber TG, Shirihai OS, Witte ON. PMID: 39589879; PMCID: PMC11626175.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. Assessment of TROP2, CEACAM5 and DLL3 in metastatic prostate cancer: Expression landscape and molecular correlates. NPJ Precis Oncol. 2024 May 17; 8(1):104. Ajkunic A, Sayar E, Roudier MP, Patel RA, Coleman IM, De Sarkar N, Hanratty B, Adil M, Zhao J, Zaidi S, True LD, Sperger JM, Cheng HH, Yu EY, Montgomery RB, Hawley JE, Ha G, Persse T, Galipeau P, Lee JK, Harmon SA, Corey E, Lang JM, Sawyers CL, Morrissey C, Schweizer MT, Gulati R, Nelson PS, Haffner MC. PMID: 38760413; PMCID: PMC11101486.
      View in: PubMed   Mentions: 8  
    5. A combinatorial genetic strategy for exploring complex genotype-phenotype associations in cancer. Nat Genet. 2024 Mar; 56(3):371-376. Li S, Wong A, Sun H, Bhatia V, Javier G, Jana S, Wu Q, Montgomery RB, Wright JL, Lam HM, Hsieh AC, Faltas BM, Haffner MC, Lee JK. PMID: 38424461; PMCID: PMC10937382.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    6. Concurrent Targeting of HDAC and PI3K to Overcome Phenotypic Heterogeneity of Castration-resistant and Neuroendocrine Prostate Cancers. Cancer Res Commun. 2023 11 20; 3(11):2358-2374. Zhang A, Lau NA, Wong A, Brown LG, Coleman IM, De Sarkar N, Li D, DeLucia DC, Labrecque MP, Nguyen HM, Conner JL, Dumpit RF, True LD, Lin DW, Corey E, Alumkal JJ, Nelson PS, Morrissey C, Lee JK. PMID: 37823778; PMCID: PMC10658857.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    7. Tumor-derived biomarkers predict efficacy of B7H3 antibody-drug conjugate treatment in metastatic prostate cancer models. J Clin Invest. 2023 11 15; 133(22). Agarwal S, Fang L, McGowen K, Yin J, Bowman J, Ku AT, Alilin AN, Corey E, Roudier MP, True LD, Dumpit R, Coleman I, Lee JK, Nelson PS, Capaldo BJ, Mariani A, Hoover C, Senatorov IS, Beshiri M, Sowalsky AG, Hurt EM, Kelly K. PMID: 37725435; PMCID: PMC10645377.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    8. Targeting the fibroblast growth factor pathway in molecular subtypes of castration-resistant prostate cancer. Prostate. 2024 Jan; 84(1):100-110. Labrecque MP, Brown LG, Coleman IM, Nguyen HM, Dalrymple S, Brennen WN, Isaacs JT, Li D, Lakely B, DeLucia DC, Lee JK, Schweizer MT, Lin DW, Corey E, Nelson PS, Morrissey C. PMID: 37796107; PMCID: PMC10851871.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    9. LSD1 promotes prostate cancer reprogramming by repressing TP53 signaling independently of its demethylase function. JCI Insight. 2023 08 08; 8(15). Kumaraswamy A, Duan Z, Flores D, Zhang C, Sehrawat A, Hu YM, Swaim OA, Rodansky E, Storck WK, Kuleape JA, Bedi K, Mannan R, Wang XM, Udager A, Ravikumar V, Bankhead A, Coleman I, Lee JK, Morrissey C, Nelson PS, Chinnaiyan AM, Rao A, Xia Z, Yates JA, Alumkal JJ. PMID: 37440313; PMCID: PMC10445684.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    10. Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting. Nat Commun. 2023 08 07; 14(1):4737. Lee EHJ, Murad JP, Christian L, Gibson J, Yamaguchi Y, Cullen C, Gumber D, Park AK, Young C, Monroy I, Yang J, Stern LA, Adkins LN, Dhapola G, Gittins B, Chang WC, Martinez C, Woo Y, Cristea M, Rodriguez-Rodriguez L, Ishihara J, Lee JK, Forman SJ, Wang LD, Priceman SJ. PMID: 37550294; PMCID: PMC10406808.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    11. Androgen-regulated stromal complement component 7 (C7) suppresses prostate cancer growth. Oncogene. 2023 08; 42(32):2428-2438. Zhou Z, Jia D, Kwon O, Li S, Sun H, Roudier MP, Lin DW, True L, Morrissey C, Creighton CJ, Lee JK, Xin L. PMID: 37400528; PMCID: PMC10802183.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    12. Metastatic Bladder Cancer Expression and Subcellular Localization of Nectin-4 and Trop-2 in Variant Histology: A Rapid Autopsy Study. Clin Genitourin Cancer. 2023 12; 21(6):669-678. Ghali F, Vakar-Lopez F, Roudier MP, Garcia J, Arora S, Cheng HH, Schweizer MT, Haffner MC, Lee JK, Yu EY, Grivas P, Montgomery B, Hsieh AC, Wright JL, Lam HM. PMID: 37344281; PMCID: PMC10674028.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    13. Large libraries of single-chain trimer peptide-MHCs enable antigen-specific CD8+ T cell discovery and analysis. Commun Biol. 2023 05 16; 6(1):528. Chour W, Choi J, Xie J, Chaffee ME, Schmitt TM, Finton K, DeLucia DC, Xu AM, Su Y, Chen DG, Zhang R, Yuan D, Hong S, Ng AHC, Butler JZ, Edmark RA, Jones LC, Murray KM, Peng S, Li G, Strong RK, Lee JK, Goldman JD, Greenberg PD, Heath JR. PMID: 37193826; PMCID: PMC10186326.
      View in: PubMed   Mentions: 5  Translation:HumansCells
    14. Expanding the landscape of TCR gene therapy targeting MAGE. Mol Ther Oncolytics. 2023 Jun 15; 29:59-60. Mao Z, Lee JK. PMID: 37215387; PMCID: PMC10195836.
      View in: PubMed   Mentions: 1  
    15. Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression. Cancer Cell. 2023 05 08; 41(5):853-870.e13. Jana S, Brahma S, Arora S, Wladyka CL, Hoang P, Blinka S, Hough R, Horn JL, Liu Y, Wang LJ, Depeille P, Smith E, Montgomery RB, Lee JK, Haffner MC, Vakar-Lopez F, Grivas P, Wright JL, Lam HM, Black PC, Roose JP, Ryazanov AG, Subramaniam AR, Henikoff S, Hsieh AC. PMID: 37084735; PMCID: PMC10208629.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    16. Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations. bioRxiv. 2023 Apr 14. Li S, Wong A, Sun H, Bhatia V, Javier G, Jana S, Montgomery RB, Wright JL, Lam HM, Hsieh AC, Faltas BM, Haffner MC, Lee JK. PMID: 37609344; PMCID: PMC10441433.
      View in: PubMed   Mentions:
    17. Targeting advanced prostate cancer with STEAP1 chimeric antigen receptor T cell and tumor-localized IL-12 immunotherapy. Nat Commun. 2023 04 11; 14(1):2041. Bhatia V, Kamat NV, Pariva TE, Wu LT, Tsao A, Sasaki K, Sun H, Javier G, Nutt S, Coleman I, Hitchcock L, Zhang A, Rudoy D, Gulati R, Patel RA, Roudier MP, True LD, Srivastava S, Morrissey CM, Haffner MC, Nelson PS, Priceman SJ, Ishihara J, Lee JK. PMID: 37041154; PMCID: PMC10090190.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    18. Reversible epigenetic alterations mediate PSMA expression heterogeneity in advanced metastatic prostate cancer. JCI Insight. 2023 04 10; 8(7). Sayar E, Patel RA, Coleman IM, Roudier MP, Zhang A, Mustafi P, Low JY, Hanratty B, Ang LS, Bhatia V, Adil M, Bakbak H, Quigley DA, Schweizer MT, Hawley JE, Kollath L, True LD, Feng FY, Bander NH, Corey E, Lee JK, Morrissey C, Gulati R, Nelson PS, Haffner MC. PMID: 36821396; PMCID: PMC10132157.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    19. Entropic analysis of antigen-specific CDR3 domains identifies essential binding motifs shared by CDR3s with different antigen specificities. Cell Syst. 2023 04 19; 14(4):273-284.e5. Xu AM, Chour W, DeLucia DC, Su Y, Pavlovitch-Bedzyk AJ, Ng R, Rasheed Y, Davis MM, Lee JK, Heath JR. PMID: 37001518; PMCID: PMC10355346.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    20. Internet-Based Germline Genetic Testing for Men With Metastatic Prostate Cancer. JCO Precis Oncol. 2023 01; 7:e2200104. Cheng HH, Sokolova AO, Gulati R, Bowen D, Knerr SA, Klemfuss N, Grivas P, Hsieh A, Lee JK, Schweizer MT, Yezefski T, Zhou A, Yu EY, Nelson PS, Montgomery B. PMID: 36623239; PMCID: PMC9928882.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    21. Genomic Characterization of Prostatic Basal Cell Carcinoma. Am J Pathol. 2023 01; 193(1):4-10. Low JY, Ko M, Hanratty B, Patel RA, Bhamidipati A, Heaphy CM, Sayar E, Lee JK, Li S, De Marzo AM, Nelson WG, Gupta A, Yegnasubramanian S, Ha G, Epstein JI, Haffner MC. PMID: 36309102; PMCID: PMC9768679.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    22. Physical and in silico immunopeptidomic profiling of a cancer antigen prostatic acid phosphatase reveals targets enabling TCR isolation. Proc Natl Acad Sci U S A. 2022 08 02; 119(31):e2203410119. Mao Z, Nesterenko PA, McLaughlin J, Deng W, Burton Sojo G, Cheng D, Noguchi M, Chour W, DeLucia DC, Finton KA, Qin Y, Obusan MB, Tran W, Wang L, Bangayan NJ, Ta L, Chen CC, Seet CS, Crooks GM, Phillips JW, Heath JR, Strong RK, Lee JK, Wohlschlegel JA, Witte ON. PMID: 35878026; PMCID: PMC9351518.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    23. Comprehensive assessment of anaplastic lymphoma kinase in localized and metastatic prostate cancer reveals targetable alterations. Cancer Res Commun. 2022 05; 2(5):277-285. Patel RA, Coleman I, Roudier MP, Konnick EQ, Hanratty B, Dumpit R, Lucas JM, Ang LS, Low JY, Tretiakova MS, Ha G, Lee JK, True LD, De Marzo AM, Nelson PS, Morrissey C, Pritchard CC, Haffner MC. PMID: 36337169; PMCID: PMC9635400.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    24. Development of Cancer Immunotherapies. Cancer Treat Res. 2022; 183:1-48. DeLucia DC, Lee JK. PMID: 35551655.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    25. Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Nat Commun. 2021 08 09; 12(1):4789. Vichas A, Riley AK, Nkinsi NT, Kamlapurkar S, Parrish PCR, Lo A, Duke F, Chen J, Fung I, Watson J, Rees M, Gabel AM, Thomas JD, Bradley RK, Lee JK, Hatch EM, Baine MK, Rekhtman N, Ladanyi M, Piccioni F, Berger AH. PMID: 34373451; PMCID: PMC8352964.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    26. RNA Splicing Factors SRRM3 and SRRM4 Distinguish Molecular Phenotypes of Castration-Resistant Neuroendocrine Prostate Cancer. Cancer Res. 2021 09 15; 81(18):4736-4750. Labrecque MP, Brown LG, Coleman IM, Lakely B, Brady NJ, Lee JK, Nguyen HM, Li D, Hanratty B, Haffner MC, Rickman DS, True LD, Lin DW, Lam HM, Alumkal JJ, Corey E, Nelson PS, Morrissey C. PMID: 34312180; PMCID: PMC8448969.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    27. BiTE-ing into Prostate Cancer with Bispecific T-cell Engagers. Clin Cancer Res. 2021 05 15; 27(10):2675-2677. Kamat NV, Yu EY, Lee JK. PMID: 33707179; PMCID: PMC8127346.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    28. A bladder cancer patient-derived xenograft displays aggressive growth dynamics in vivo and in organoid culture. Sci Rep. 2021 02 25; 11(1):4609. Cai EY, Garcia J, Liu Y, Vakar-Lopez F, Arora S, Nguyen HM, Lakely B, Brown L, Wong A, Montgomery B, Lee JK, Corey E, Wright JL, Hsieh AC, Lam HM. PMID: 33633154; PMCID: PMC7907272.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    29. Patterns and timing of perioperative blood transfusion and association with outcomes after radical cystectomy. Urol Oncol. 2021 08; 39(8):496.e1-496.e8. Diamantopoulos LN, Sekar RR, Holt SK, Khaki AR, Miller NJ, Gadzinski A, Nyame YA, Vakar-Lopez F, Tretiakova MS, Psutka SP, Gore JL, Lin DW, Schade GR, Hsieh AC, Lee JK, Yezefski T, Schweizer MT, Cheng HH, Yu EY, True LD, Montgomery RB, Grivas P, Wright JL. PMID: 33551249.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    30. Regulation of CEACAM5 and Therapeutic Efficacy of an Anti-CEACAM5-SN38 Antibody-drug Conjugate in Neuroendocrine Prostate Cancer. Clin Cancer Res. 2021 02 01; 27(3):759-774. DeLucia DC, Cardillo TM, Ang L, Labrecque MP, Zhang A, Hopkins JE, De Sarkar N, Coleman I, da Costa RMG, Corey E, True LD, Haffner MC, Schweizer MT, Morrissey C, Nelson PS, Lee JK. PMID: 33199493; PMCID: PMC7854497.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    31. Response to Neoadjuvant Chemotherapy and Survival in Micropapillary Urothelial Carcinoma: Data From a Tertiary Referral Center and the Surveillance, Epidemiology, and End Results (SEER) Program. Clin Genitourin Cancer. 2021 04; 19(2):144-154. Diamantopoulos LN, Holt SK, Khaki AR, Sekar RR, Gadzinski A, Nyame YA, Vakar-Lopez F, Tretiakova MS, Psutka SP, Gore JL, Lin DW, Schade GR, Hsieh AC, Lee JK, Yezefski T, Schweizer MT, Cheng HH, Yu EY, True LD, Montgomery RB, Grivas P, Wright JL. PMID: 33160889; PMCID: PMC8044249.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    32. De novo induction of lineage plasticity from human prostate luminal epithelial cells by activated AKT1 and c-Myc. Oncogene. 2020 11; 39(48):7142-7151. Kwon OJ, Zhang L, Jia D, Zhou Z, Li Z, Haffner M, Lee JK, True L, Morrissey C, Xin L. PMID: 33009488; PMCID: PMC7704645.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    33. Targeting RET Kinase in Neuroendocrine Prostate Cancer. Mol Cancer Res. 2020 08; 18(8):1176-1188. VanDeusen HR, Ramroop JR, Morel KL, Bae SY, Sheahan AV, Sychev Z, Lau NA, Cheng LC, Tan VM, Li Z, Petersen A, Lee JK, Park JW, Yang R, Hwang JH, Coleman I, Witte ON, Morrissey C, Corey E, Nelson PS, Ellis L, Drake JM. PMID: 32461304; PMCID: PMC7415621.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    34. Plasmacytoid urothelial carcinoma: response to chemotherapy and oncologic outcomes. Bladder Cancer. 2020; 6(1):71-81. Diamantopoulos LN, Khaki AR, Grivas P, Gore JL, Schade GR, Hsieh AC, Lee JK, Yezefski T, Yu EY, Schweizer MT, Cheng HH, Psutka SP, Lin DW, Tretiakova MS, Vakar-Lopez F, Montgomery RB, Wright JL. PMID: 34109262; PMCID: PMC8186525.
      View in: PubMed   Mentions: 14  
    35. Identification of Cell Surface Targets for CAR T Cell Immunotherapy. Methods Mol Biol. 2020; 2097:45-54. DeLucia DC, Lee JK. PMID: 31776917.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    36. Identification of Therapeutic Vulnerabilities in Small-cell Neuroendocrine Prostate Cancer. Clin Cancer Res. 2020 04 01; 26(7):1667-1677. Corella AN, Cabiliza Ordonio MVA, Coleman I, Lucas JM, Kaipainen A, Nguyen HM, Sondheim D, Brown LG, True LD, Lee JK, MacPherson D, Nghiem P, Gulati R, Morrissey C, Corey E, Nelson PS. PMID: 31806643; PMCID: PMC7124974.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    37. Targeting cellular heterogeneity with CXCR2 blockade for the treatment of therapy-resistant prostate cancer. Sci Transl Med. 2019 12 04; 11(521). Li Y, He Y, Butler W, Xu L, Chang Y, Lei K, Zhang H, Zhou Y, Gao AC, Zhang Q, Taylor DG, Cheng D, Farber-Katz S, Karam R, Landrith T, Li B, Wu S, Hsuan V, Yang Q, Hu H, Chen X, Flowers M, McCall SJ, Lee JK, Smith BA, Park JW, Goldstein AS, Witte ON, Wang Q, Rettig MB, Armstrong AJ, Cheng Q, Huang J. PMID: 31801883; PMCID: PMC7238624.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    38. PEG10 Promoter-Driven Expression of Reporter Genes Enables Molecular Imaging of Lethal Prostate Cancer. Cancer Res. 2019 11 01; 79(21):5668-5680. Shapovalova M, Lee JK, Li Y, Vander Griend DJ, Coleman IM, Nelson PS, Dehm SM, LeBeau AM. PMID: 31530569; PMCID: PMC6825593.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    39. The Role of Lineage Plasticity in Prostate Cancer Therapy Resistance. Clin Cancer Res. 2019 12 01; 25(23):6916-6924. Beltran H, Hruszkewycz A, Scher HI, Hildesheim J, Isaacs J, Yu EY, Kelly K, Lin D, Dicker A, Arnold J, Hecht T, Wicha M, Sears R, Rowley D, White R, Gulley JL, Lee J, Diaz Meco M, Small EJ, Shen M, Knudsen K, Goodrich DW, Lotan T, Zoubeidi A, Sawyers CL, Rudin CM, Loda M, Thompson T, Rubin MA, Tawab-Amiri A, Dahut W, Nelson PS. PMID: 31363002; PMCID: PMC6891154.
      View in: PubMed   Mentions: 196     Fields:    Translation:Humans
    40. Genomic distinctions between metastatic lower and upper tract urothelial carcinoma revealed through rapid autopsy. JCI Insight. 2019 05 30; 5. Winters BR, De Sarkar N, Arora S, Bolouri H, Jana S, Vakar-Lopez F, Cheng HH, Schweizer MT, Yu EY, Grivas P, Lee JK, Kollath L, Holt SK, McFerrin L, Ha G, Nelson PS, Montgomery RB, Wright JL, Lam HM, Hsieh AC. PMID: 31145100; PMCID: PMC6629128.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    41. Precision Medicine-Enabled Cancer Immunotherapy. Cancer Treat Res. 2019; 178:189-205. Lee JK, Priceman SJ. PMID: 31209846.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    42. Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage. Science. 2018 10 05; 362(6410):91-95. Park JW, Lee JK, Sheu KM, Wang L, Balanis NG, Nguyen K, Smith BA, Cheng C, Tsai BL, Cheng D, Huang J, Kurdistani SK, Graeber TG, Witte ON. PMID: 30287662; PMCID: PMC6414229.
      View in: PubMed   Mentions: 165     Fields:    Translation:HumansCells
    43. Systemic surfaceome profiling identifies target antigens for immune-based therapy in subtypes of advanced prostate cancer. Proc Natl Acad Sci U S A. 2018 05 08; 115(19):E4473-E4482. Lee JK, Bangayan NJ, Chai T, Smith BA, Pariva TE, Yun S, Vashisht A, Zhang Q, Park JW, Corey E, Huang J, Graeber TG, Wohlschlegel J, Witte ON. PMID: 29686080; PMCID: PMC5949005.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    44. FOXA2 is a sensitive and specific marker for small cell neuroendocrine carcinoma of the prostate. Mod Pathol. 2017 09; 30(9):1262-1272. Park JW, Lee JK, Witte ON, Huang J. PMID: 28621319; PMCID: PMC6330177.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    45. Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2016 10 18; 113(42):E6457-E6466. Stoyanova T, Riedinger M, Lin S, Faltermeier CM, Smith BA, Zhang KX, Going CC, Goldstein AS, Lee JK, Drake JM, Rice MA, Hsu EC, Nowroozizadeh B, Castor B, Orellana SY, Blum SM, Cheng D, Pienta KJ, Reiter RE, Pitteri SJ, Huang J, Witte ON. PMID: 27694579; PMCID: PMC5081658.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    46. Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer. Cell. 2016 Aug 11; 166(4):1041-1054. Drake JM, Paull EO, Graham NA, Lee JK, Smith BA, Titz B, Stoyanova T, Faltermeier CM, Uzunangelov V, Carlin DE, Fleming DT, Wong CK, Newton Y, Sudha S, Vashisht AA, Huang J, Wohlschlegel JA, Graeber TG, Witte ON, Stuart JM. PMID: 27499020; PMCID: PMC4985183.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansCells
    47. Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay. Proc Natl Acad Sci U S A. 2016 Apr 19; 113(16):4482-7. Park JW, Lee JK, Phillips JW, Huang P, Cheng D, Huang J, Witte ON. PMID: 27044116; PMCID: PMC4843433.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    48. N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells. Cancer Cell. 2016 Apr 11; 29(4):536-547. Lee JK, Phillips JW, Smith BA, Park JW, Stoyanova T, McCaffrey EF, Baertsch R, Sokolov A, Meyerowitz JG, Mathis C, Cheng D, Stuart JM, Shokat KM, Gustafson WC, Huang J, Witte ON. PMID: 27050099; PMCID: PMC4829466.
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    49. Clinical targeting of mutated and wild-type protein tyrosine kinases in cancer. Mol Cell Biol. 2014 May; 34(10):1722-32. Drake JM, Lee JK, Witte ON. PMID: 24567371; PMCID: PMC4019040.
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    50. Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets. Proc Natl Acad Sci U S A. 2013 Dec 03; 110(49):E4762-9. Drake JM, Graham NA, Lee JK, Stoyanova T, Faltermeier CM, Sud S, Titz B, Huang J, Pienta KJ, Graeber TG, Witte ON. PMID: 24248375; PMCID: PMC3856845.
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    51. Blastic plasmacytoid dendritic cell neoplasm. Clin Adv Hematol Oncol. 2012 Jan; 10(1):60-2. Lee JK, Schiller G. PMID: 22398811.
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