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Michael B Elowitz

Title(s)Assistant Adjunct Professor, Biological Chemistry
SchoolMedicine
Address760 Westwood Plaza 337
Los Angeles CA 90024
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    MEMOIR: Recording, and in situ readout of cell lineage and transcriptional history
    NIH/NIMH R01MH116508Sep 20, 2017 - Jun 30, 2022
    Role: Principal Investigator
    Quantitative Single-Cell Analysis of Mammalian Notch Signaling States
    NIH/NICHD R01HD075335Sep 26, 2012 - Jun 30, 2017
    Role: Principal Investigator
    Genetic Interactions and Synthetic Population Biology
    NIH/NIGMS R01GM086793Sep 1, 2010 - Jun 30, 2014
    Role: Principal Investigator
    Stochastic Pulsing in Microbial Regulation and Differentiation
    NIH/NIGMS R01GM079771Feb 1, 2007 - Jun 30, 2016
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Publisher Correction: In situ readout of DNA barcodes and single base edits facilitated by in vitro transcription. Nat Biotechnol. 2020 Feb; 38(2):245. Askary A, Sanchez-Guardado L, Linton JM, Chadly DM, Budde MW, Cai L, Lois C, Elowitz MB. PMID: 31988471.
      View in: PubMed   Mentions:    Fields:    
    2. In situ readout of DNA barcodes and single base edits facilitated by in vitro transcription. Nat Biotechnol. 2020 01; 38(1):66-75. Askary A, Sanchez-Guardado L, Linton JM, Chadly DM, Budde MW, Cai L, Lois C, Elowitz MB. PMID: 31740838.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    3. Communication codes in developmental signaling pathways. Development. 2019 06 27; 146(12). Li P, Elowitz MB. PMID: 31249008.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    4. Constitutive splicing and economies of scale in gene expression. Nat Struct Mol Biol. 2019 06; 26(6):424-432. Ding F, Elowitz MB. PMID: 31133700.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    5. Cis-activation in the Notch signaling pathway. Elife. 2019 01 10; 8. Nandagopal N, Santat LA, Elowitz MB. PMID: 30628888.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    6. A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment. Elife. 2018 11 20; 7. Ng KK, Yui MA, Mehta A, Siu S, Irwin B, Pease S, Hirose S, Elowitz MB, Rothenberg EV, Kueh HY. PMID: 30457103.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    7. Self-Amplifying Pulsatile Protein Dynamics without Positive Feedback. Cell Syst. 2018 10 24; 7(4):453-462.e1. Martinez-Corral R, Raimundez E, Lin Y, Elowitz MB, Garcia-Ojalvo J. PMID: 30316816.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    8. Programmable protein circuits in living cells. Science. 2018 09 21; 361(6408):1252-1258. Gao XJ, Chong LS, Kim MS, Elowitz MB. PMID: 30237357.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    9. Metabolic interactions between dynamic bacterial subpopulations. Elife. 2018 05 29; 7. Rosenthal AZ, Qi Y, Hormoz S, Park J, Li SH, Elowitz MB. PMID: 29809139.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    10. Morphogen gradient reconstitution reveals Hedgehog pathway design principles. Science. 2018 05 04; 360(6388):543-548. Li P, Markson JS, Wang S, Chen S, Vachharajani V, Elowitz MB. PMID: 29622726.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    11. Molecular Time Sharing through Dynamic Pulsing in Single Cells. Cell Syst. 2018 Feb 28; 6(2):216-229.e15. Park J, Dies M, Lin Y, Hormoz S, Smith-Unna SE, Quinodoz S, Hernández-Jiménez MJ, Garcia-Ojalvo J, Locke JCW, Elowitz MB. PMID: 29454936.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    12. Dynamic Ligand Discrimination in the Notch Signaling Pathway. Cell. 2018 02 08; 172(4):869-880.e19. Nandagopal N, Santat LA, LeBon L, Sprinzak D, Bronner ME, Elowitz MB. PMID: 29398116.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    13. Combinatorial Signal Perception in the BMP Pathway. Cell. 2017 Sep 07; 170(6):1184-1196.e24. Antebi YE, Linton JM, Klumpe H, Bintu B, Gong M, Su C, McCardell R, Elowitz MB. PMID: 28886385.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    14. Challenges and emerging directions in single-cell analysis. Genome Biol. 2017 05 08; 18(1):84. Yuan GC, Cai L, Elowitz M, Enver T, Fan G, Guo G, Irizarry R, Kharchenko P, Kim J, Orkin S, Quackenbush J, Saadatpour A, Schroeder T, Shivdasani R, Tirosh I. PMID: 28482897.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimals
    15. An operational view of intercellular signaling pathways. Curr Opin Syst Biol. 2017 Feb; 1:16-24. Antebi YE, Nandagopal N, Elowitz MB. PMID: 29104946.
      View in: PubMed   Mentions:
    16. Inferring Cell-State Transition Dynamics from Lineage Trees and Endpoint Single-Cell Measurements. Cell Syst. 2016 11 23; 3(5):419-433.e8. Hormoz S, Singer ZS, Linton JM, Antebi YE, Shraiman BI, Elowitz MB. PMID: 27883889.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    17. Synthetic recording and in situ readout of lineage information in single cells. Nature. 2017 01 05; 541(7635):107-111. Frieda KL, Linton JM, Hormoz S, Choi J, Chow KK, Singer ZS, Budde MW, Elowitz MB, Cai L. PMID: 27869821.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    18. Synthetic biology: Precision timing in a cell. Nature. 2016 10 27; 538(7626):462-463. Gao XJ, Elowitz MB. PMID: 27732579.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. Asynchronous combinatorial action of four regulatory factors activates Bcl11b for T cell commitment. Nat Immunol. 2016 08; 17(8):956-65. Kueh HY, Yui MA, Ng KK, Pease SS, Zhang JA, Damle SS, Freedman G, Siu S, Bernstein ID, Elowitz MB, Rothenberg EV. PMID: 27376470.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    20. Central Dogma Goes Digital. Mol Cell. 2016 Mar 17; 61(6):791-2. Lin Y, Elowitz MB. PMID: 26990983.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    21. Dynamics of epigenetic regulation at the single-cell level. Science. 2016 Feb 12; 351(6274):720-4. Bintu L, Yong J, Antebi YE, McCue K, Kazuki Y, Uno N, Oshimura M, Elowitz MB. PMID: 26912859.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    22. Combinatorial gene regulation by modulation of relative pulse timing. Nature. 2015 Nov 05; 527(7576):54-8. Lin Y, Sohn CH, Dalal CK, Cai L, Elowitz MB. PMID: 26466562.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    23. Single-cell transcriptome analysis reveals dynamic changes in lncRNA expression during reprogramming. Cell Stem Cell. 2015 Jan 08; 16(1):88-101. Kim DH, Marinov GK, Pepke S, Singer ZS, He P, Williams B, Schroth GP, Elowitz MB, Wold BJ. PMID: 25575081.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    24. Synthetic biology of multicellular systems: new platforms and applications for animal cells and organisms. ACS Synth Biol. 2014 Dec 19; 3(12):875-6. Markson JS, Elowitz MB. PMID: 25524091.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    25. Polyphasic feedback enables tunable cellular timers. Curr Biol. 2014 Oct 20; 24(20):R994-5. Levine JH, Elowitz MB. PMID: 25442853.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    26. Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states. Elife. 2014 Sep 25; 3:e02950. LeBon L, Lee TV, Sprinzak D, Jafar-Nejad H, Elowitz MB. PMID: 25255098.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    27. Pulsatile dynamics in the yeast proteome. Curr Biol. 2014 Sep 22; 24(18):2189-2194. Dalal CK, Cai L, Lin Y, Rahbar K, Elowitz MB. PMID: 25220054.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    28. Dynamic heterogeneity and DNA methylation in embryonic stem cells. Mol Cell. 2014 Jul 17; 55(2):319-31. Singer ZS, Yong J, Tischler J, Hackett JA, Altinok A, Surani MA, Cai L, Elowitz MB. PMID: 25038413.
      View in: PubMed   Mentions: 104     Fields:    Translation:AnimalsCells
    29. Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase. Proc Natl Acad Sci U S A. 2014 Apr 29; 111(17):E1740-8. Tan FE, Elowitz MB. PMID: 24733888.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    30. Realizing the potential of synthetic biology. Nat Rev Mol Cell Biol. 2014 04; 15(4):289-94. Church GM, Elowitz MB, Smolke CD, Voigt CA, Weiss R. PMID: 24622617.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    31. Functional roles of pulsing in genetic circuits. Science. 2013 Dec 06; 342(6163):1193-200. Levine JH, Lin Y, Elowitz MB. PMID: 24311681.
      View in: PubMed   Mentions: 105     Fields:    Translation:AnimalsCells
    32. Positive feedback between PU.1 and the cell cycle controls myeloid differentiation. Science. 2013 Aug 09; 341(6146):670-3. Kueh HY, Champhekar A, Champhekhar A, Nutt SL, Elowitz MB, Rothenberg EV. PMID: 23868921.
      View in: PubMed   Mentions: 98     Fields:    Translation:AnimalsCells
    33. Rate of environmental change determines stress response specificity. Proc Natl Acad Sci U S A. 2013 Mar 05; 110(10):4140-5. Young JW, Locke JC, Elowitz MB. PMID: 23407164.
      View in: PubMed   Mentions: 47     Fields:    Translation:Cells
    34. Pulsed feedback defers cellular differentiation. PLoS Biol. 2012 Jan; 10(1):e1001252. Levine JH, Fontes ME, Dworkin J, Elowitz MB. PMID: 22303282.
      View in: PubMed   Mentions: 53     Fields:    Translation:Cells
    35. Following evolution of bacterial antibiotic resistance in real time. Nat Genet. 2011 Dec 27; 44(1):11-3. Rosenthal AZ, Elowitz MB. PMID: 22200772.
      View in: PubMed   Mentions: 3     Fields:    
    36. Measuring single-cell gene expression dynamics in bacteria using fluorescence time-lapse microscopy. Nat Protoc. 2011 Dec 15; 7(1):80-8. Young JW, Locke JC, Altinok A, Rosenfeld N, Bacarian T, Swain PS, Mjolsness E, Elowitz MB. PMID: 22179594.
      View in: PubMed   Mentions: 92     Fields:    Translation:Cells
    37. Stochastic pulse regulation in bacterial stress response. Science. 2011 Oct 21; 334(6054):366-9. Locke JC, Young JW, Fontes M, Hernández Jiménez MJ, Elowitz MB. PMID: 21979936.
      View in: PubMed   Mentions: 71     Fields:    Translation:Cells
    38. The ePetri dish, an on-chip cell imaging platform based on subpixel perspective sweeping microscopy (SPSM). Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):16889-94. Zheng G, Lee SA, Antebi Y, Elowitz MB, Yang C. PMID: 21969539.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    39. Dynamical consequences of bandpass feedback loops in a bacterial phosphorelay. PLoS One. 2011; 6(9):e25102. Sen S, Garcia-Ojalvo J, Elowitz MB. PMID: 21980382.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    40. Synthetic biology: integrated gene circuits. Science. 2011 Sep 02; 333(6047):1244-8. Nandagopal N, Elowitz MB. PMID: 21885772.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    41. Mutual inactivation of Notch receptors and ligands facilitates developmental patterning. PLoS Comput Biol. 2011 Jun; 7(6):e1002069. Sprinzak D, Lakhanpal A, LeBon L, Garcia-Ojalvo J, Elowitz MB. PMID: 21695234.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    42. Mixed messages: how bacteria resolve conflicting signals. Mol Cell. 2011 May 20; 42(4):405-6. Young JW, Elowitz MB. PMID: 21596304.
      View in: PubMed   Mentions:    Fields:    
    43. Build life to understand it. Nature. 2010 Dec 16; 468(7326):889-90. Elowitz M, Lim WA. PMID: 21164460.
      View in: PubMed   Mentions: 47     Fields:    Translation:Animals
    44. A general mechanism for network-dosage compensation in gene circuits. Science. 2010 Sep 24; 329(5999):1656-60. Acar M, Pando BF, Arnold FH, Elowitz MB, van Oudenaarden A. PMID: 20929850.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    45. Functional roles for noise in genetic circuits. Nature. 2010 Sep 09; 467(7312):167-73. Eldar A, Elowitz MB. PMID: 20829787.
      View in: PubMed   Mentions: 439     Fields:    Translation:HumansAnimals
    46. A synthetic three-color scaffold for monitoring genetic regulation and noise. J Biol Eng. 2010 Jul 21; 4:10. Cox RS, Dunlop MJ, Elowitz MB. PMID: 20646328.
      View in: PubMed   Mentions:
    47. Cis-interactions between Notch and Delta generate mutually exclusive signalling states. Nature. 2010 May 06; 465(7294):86-90. Sprinzak D, Lakhanpal A, Lebon L, Santat LA, Fontes ME, Anderson GA, Garcia-Ojalvo J, Elowitz MB. PMID: 20418862.
      View in: PubMed   Mentions: 196     Fields:    Translation:HumansAnimalsCells
    48. Architecture-dependent noise discriminates functionally analogous differentiation circuits. Cell. 2009 Oct 30; 139(3):512-22. Cagatay T, Turcotte M, Elowitz MB, Garcia-Ojalvo J, Süel GM. PMID: 19853288.
      View in: PubMed   Mentions: 102     Fields:    Translation:Cells
    49. Partial penetrance facilitates developmental evolution in bacteria. Nature. 2009 Jul 23; 460(7254):510-4. Eldar A, Chary VK, Xenopoulos P, Fontes ME, Losón OC, Dworkin J, Piggot PJ, Elowitz MB. PMID: 19578359.
      View in: PubMed   Mentions: 46     Fields:    Translation:Cells
    50. Using movies to analyse gene circuit dynamics in single cells. Nat Rev Microbiol. 2009 May; 7(5):383-92. Locke JC, Elowitz MB. PMID: 19369953.
      View in: PubMed   Mentions: 91     Fields:    Translation:Cells
    51. Regulatory activity revealed by dynamic correlations in gene expression noise. Nat Genet. 2008 Dec; 40(12):1493-8. Dunlop MJ, Cox RS, Levine JH, Murray RM, Elowitz MB. PMID: 19029898.
      View in: PubMed   Mentions: 92     Fields:    Translation:Cells
    52. Frequency-modulated nuclear localization bursts coordinate gene regulation. Nature. 2008 Sep 25; 455(7212):485-90. Cai L, Dalal CK, Elowitz MB. PMID: 18818649.
      View in: PubMed   Mentions: 189     Fields:    Translation:AnimalsCells
    53. The evolutionary dynamics of the Saccharomyces cerevisiae protein interaction network after duplication. Proc Natl Acad Sci U S A. 2008 Jan 22; 105(3):950-4. Presser A, Elowitz MB, Kellis M, Kishony R. PMID: 18199840.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    54. Accurate prediction of gene feedback circuit behavior from component properties. Mol Syst Biol. 2007; 3:143. Rosenfeld N, Young JW, Alon U, Swain PS, Elowitz MB. PMID: 18004276.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    55. Programming gene expression with combinatorial promoters. Mol Syst Biol. 2007; 3:145. Cox RS, Surette MG, Elowitz MB. PMID: 18004278.
      View in: PubMed   Mentions: 129     Fields:    Translation:Cells
    56. Tunability and noise dependence in differentiation dynamics. Science. 2007 Mar 23; 315(5819):1716-9. Süel GM, Kulkarni RP, Dworkin J, Garcia-Ojalvo J, Elowitz MB. PMID: 17379809.
      View in: PubMed   Mentions: 187     Fields:    Translation:Cells
    57. A fluctuation method to quantify in vivo fluorescence data. Biophys J. 2006 Jul 15; 91(2):759-66. Rosenfeld N, Perkins TJ, Alon U, Elowitz MB, Swain PS. PMID: 16648159.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    58. An excitable gene regulatory circuit induces transient cellular differentiation. Nature. 2006 Mar 23; 440(7083):545-50. Süel GM, Garcia-Ojalvo J, Liberman LM, Elowitz MB. PMID: 16554821.
      View in: PubMed   Mentions: 235     Fields:    Translation:Cells
    59. Reconstruction of genetic circuits. Nature. 2005 Nov 24; 438(7067):443-8. Sprinzak D, Elowitz MB. PMID: 16306982.
      View in: PubMed   Mentions: 100     Fields:    Translation:Animals
    60. Systems biology: deviations in mating. Nature. 2005 Sep 29; 437(7059):631-2. Eldar A, Elowitz M. PMID: 16193031.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    61. Gene regulation at the single-cell level. Science. 2005 Mar 25; 307(5717):1962-5. Rosenfeld N, Young JW, Alon U, Swain PS, Elowitz MB. PMID: 15790856.
      View in: PubMed   Mentions: 381     Fields:    Translation:Cells
    62. Modeling a synthetic multicellular clock: repressilators coupled by quorum sensing. Proc Natl Acad Sci U S A. 2004 Jul 27; 101(30):10955-60. Garcia-Ojalvo J, Elowitz MB, Strogatz SH. PMID: 15256602.
      View in: PubMed   Mentions: 93     Fields:    Translation:Cells
    63. Dynamics of the p53-Mdm2 feedback loop in individual cells. Nat Genet. 2004 Feb; 36(2):147-50. Lahav G, Rosenfeld N, Sigal A, Geva-Zatorsky N, Levine AJ, Elowitz MB, Alon U. PMID: 14730303.
      View in: PubMed   Mentions: 320     Fields:    Translation:HumansCells
    64. The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11547-52. Overholtzer M, Rao PH, Favis R, Lu XY, Elowitz MB, Barany F, Ladanyi M, Gorlick R, Levine AJ. PMID: 12972634.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    65. Negative autoregulation speeds the response times of transcription networks. J Mol Biol. 2002 Nov 08; 323(5):785-93. Rosenfeld N, Elowitz MB, Alon U. PMID: 12417193.
      View in: PubMed   Mentions: 221     Fields:    Translation:Cells
    66. Intrinsic and extrinsic contributions to stochasticity in gene expression. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):12795-800. Swain PS, Elowitz MB, Siggia ED. PMID: 12237400.
      View in: PubMed   Mentions: 457     Fields:    Translation:Cells
    67. Stochastic gene expression in a single cell. Science. 2002 Aug 16; 297(5584):1183-6. Elowitz MB, Levine AJ, Siggia ED, Swain PS. PMID: 12183631.
      View in: PubMed   Mentions: 1463     Fields:    Translation:Cells
    68. Combinatorial synthesis of genetic networks. Science. 2002 May 24; 296(5572):1466-70. Guet CC, Elowitz MB, Hsing W, Leibler S. PMID: 12029133.
      View in: PubMed   Mentions: 152     Fields:    Translation:Cells
    69. A synthetic oscillatory network of transcriptional regulators. Nature. 2000 Jan 20; 403(6767):335-8. Elowitz MB, Leibler S. PMID: 10659856.
      View in: PubMed   Mentions: 894     Fields:    Translation:Cells
    70. Protein mobility in the cytoplasm of Escherichia coli. J Bacteriol. 1999 Jan; 181(1):197-203. Elowitz MB, Surette MG, Wolf PE, Stock JB, Leibler S. PMID: 9864330.
      View in: PubMed   Mentions: 206     Fields:    Translation:Cells
    71. Chromophore-assisted light inactivation and self-organization of microtubules and motors. Proc Natl Acad Sci U S A. 1998 Apr 14; 95(8):4293-8. Surrey T, Elowitz MB, Wolf PE, Yang F, Nédélec F, Shokat K, Leibler S. PMID: 9539730.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    72. Photoactivation turns green fluorescent protein red. Curr Biol. 1997 Oct 01; 7(10):809-12. Elowitz MB, Surette MG, Wolf PE, Stock J, Leibler S. PMID: 9368766.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
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