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Backus, Keriann Marie

Title(s)Assistant Professor, Biological Chemistry
Phone3102068617
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    Collapse Research 
    Collapse Research Activities and Funding
    Fragment-Based Ligand Discovery in Proteomes
    NIH/NIGMS F32GM108208Jul 1, 2013 - Jun 30, 2015
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Xu JH, Eberhardt J, Hill-Payne B, González-Páez GE, Castellón JO, Cravatt BF, Forli S, Wolan DW, Backus KM. Integrative X-ray Structure and Molecular Modeling for the Rationalization of Procaspase-8 Inhibitor Potency and Selectivity. ACS Chem Biol. 2020 Feb 21; 15(2):575-586. PMID: 31927936.
      View in: PubMed
    2. Backus KM, Cao J, Maddox SM. Opportunities and challenges for the development of covalent chemical immunomodulators. Bioorg Med Chem. 2019 Aug 01; 27(15):3421-3439. PMID: 31204229.
      View in: PubMed
    3. Backus KM. Applications of Reactive Cysteine Profiling. Curr Top Microbiol Immunol. 2019; 420:375-417. PMID: 30105421.
      View in: PubMed
    4. Bar-Peled L, Kemper EK, Suciu RM, Vinogradova EV, Backus KM, Horning BD, Paul TA, Ichu TA, Svensson RU, Olucha J, Chang MW, Kok BP, Zhu Z, Ihle NT, Dix MM, Jiang P, Hayward MM, Saez E, Shaw RJ, Cravatt BF. Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer. Cell. 2017 Oct 19; 171(3):696-709.e23. PMID: 28965760.
      View in: PubMed
    5. Hacker SM, Backus KM, Lazear MR, Forli S, Correia BE, Cravatt BF. Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 12; 9(12):1181-1190. PMID: 29168484.
      View in: PubMed
    6. Touchette MH, Van Vlack ER, Bai L, Kim J, Cognetta AB, Previti ML, Backus KM, Martin DW, Cravatt BF, Seeliger JC. A Screen for Protein-Protein Interactions in Live Mycobacteria Reveals a Functional Link between the Virulence-Associated Lipid Transporter LprG and the Mycolyltransferase Antigen 85A. ACS Infect Dis. 2017 05 12; 3(5):336-348. PMID: 28276676.
      View in: PubMed
    7. Guo CJ, Chang FY, Wyche TP, Backus KM, Acker TM, Funabashi M, Taketani M, Donia MS, Nayfach S, Pollard KS, Craik CS, Cravatt BF, Clardy J, Voigt CA, Fischbach MA. Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases. Cell. 2017 01 26; 168(3):517-526.e18. PMID: 28111075.
      View in: PubMed
    8. Chen YC, Backus KM, Merkulova M, Yang C, Brown D, Cravatt BF, Zhang C. Covalent Modulators of the Vacuolar ATPase. J Am Chem Soc. 2017 01 18; 139(2):639-642. PMID: 28010062.
      View in: PubMed
    9. Horning BD, Suciu RM, Ghadiri DA, Ulanovskaya OA, Matthews ML, Lum KM, Backus KM, Brown SJ, Rosen H, Cravatt BF. Chemical Proteomic Profiling of Human Methyltransferases. J Am Chem Soc. 2016 10 12; 138(40):13335-13343. PMID: 27689866.
      View in: PubMed
    10. Blewett MM, Xie J, Zaro BW, Backus KM, Altman A, Teijaro JR, Cravatt BF. Chemical proteomic map of dimethyl fumarate-sensitive cysteines in primary human T cells. Sci Signal. 2016 09 13; 9(445):rs10. PMID: 27625306.
      View in: PubMed
    11. Briggs KJ, Koivunen P, Cao S, Backus KM, Olenchock BA, Patel H, Zhang Q, Signoretti S, Gerfen GJ, Richardson AL, Witkiewicz AK, Cravatt BF, Clardy J, Kaelin WG. Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine. Cell. 2016 Jun 30; 166(1):126-39. PMID: 27368101.
      View in: PubMed
    12. Backus KM, Correia BE, Lum KM, Forli S, Horning BD, González-Páez GE, Chatterjee S, Lanning BR, Teijaro JR, Olson AJ, Wolan DW, Cravatt BF. Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 06 23; 534(7608):570-4. PMID: 27309814.
      View in: PubMed
    13. Backus KM, Dolan MA, Barry CS, Joe M, McPhie P, Boshoff HI, Lowary TL, Davis BG, Barry CE. The three Mycobacterium tuberculosis antigen 85 isoforms have unique substrates and activities determined by non-active site regions. J Biol Chem. 2014 Sep 05; 289(36):25041-53. PMID: 25028517.
      View in: PubMed
    14. Barry CS, Backus KM, Barry CE, Davis BG. ESI-MS assay of M. tuberculosis cell wall antigen 85 enzymes permits substrate profiling and design of a mechanism-based inhibitor. J Am Chem Soc. 2011 Aug 31; 133(34):13232-5. PMID: 21776980.
      View in: PubMed
    15. Backus KM, Boshoff HI, Barry CS, Boutureira O, Patel MK, D'Hooge F, Lee SS, Via LE, Tahlan K, Barry CE, Davis BG. Uptake of unnatural trehalose analogs as a reporter for Mycobacterium tuberculosis. Nat Chem Biol. 2011 Apr; 7(4):228-35. PMID: 21378984.
      View in: PubMed