Keriann Marie Backus

Title(s)Associate Professor, Biological Chemistry
SchoolMedicine
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    A systems-level approach to decipher the protein interactome.
    NIH DP2GM146246Sep 23, 2021 - Aug 31, 2024
    Role: Principal Investigator
    Fragment-Based Ligand Discovery in Proteomes
    NIH F32GM108208Jul 1, 2013 - Jun 30, 2015
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chemoproteogenomic stratification of the missense variant cysteinome. Nat Commun. 2024 Oct 28; 15(1):9284. Desai H, Andrews KH, Bergersen KV, Ofori S, Yu F, Shikwana F, Arbing MA, Boatner LM, Villanueva M, Ung N, Reed EF, Nesvizhskii AI, Backus KM. PMID: 39468056; PMCID: PMC11519605.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Delineating cysteine-reactive compound modulation of cellular proteostasis processes. Nat Chem Biol. 2024 Oct 24. Julio AR, Shikwana F, Truong C, Burton NR, Dominguez ER, Turmon AC, Cao J, Backus KM. PMID: 39448844.
      View in: PubMed   Mentions:    Fields:    
    3. Cholesterol binding to VCAM-1 promotes vascular inflammation. bioRxiv. 2024 Sep 18. Kennelly JP, Xiao X, Gao Y, Kim S, Hong SG, Villanueva M, Ferrari A, Vanharanta L, Nguyen A, Nagari RT, Burton NR, Tol MJ, Becker AP, Lee MJ, Ikonen E, Backus KM, Mack JJ, Tontonoz P. PMID: 39345495; PMCID: PMC11429921.
      View in: PubMed   Mentions:
    4. Lipid- and protein-directed photosensitizer proximity labeling captures the cholesterol interactome. bioRxiv. 2024 Aug 24. Becker AP, Biletch E, Kennelly JP, Julio AR, Villaneuva M, Nagari RT, Turner DW, Burton NR, Fukuta T, Cui L, Xiao X, Hong SG, Mack JJ, Tontonoz P, Backus KM. PMID: 39229057; PMCID: PMC11370482.
      View in: PubMed   Mentions:
    5. Generating cysteine-trypsin cleavage sites with 2-chloroacetamidine capping. Chem Commun (Camb). 2024 Aug 15; 60(67):8856-8859. Ofori S, Desai HS, Shikwana F, Boatner LM, Dominguez Iii ER, Castellón JO, Backus KM. PMID: 39081146.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Distributable, metabolic PET reporting of tuberculosis. Nat Commun. 2024 Jun 27; 15(1):5239. Khan RMN, Ahn YM, Marriner GA, Via LE, D'Hooge F, Seo Lee S, Yang N, Basuli F, White AG, Tomko JA, Frye LJ, Scanga CA, Weiner DM, Sutphen ML, Schimel DM, Dayao E, Piazza MK, Gomez F, Dieckmann W, Herscovitch P, Mason NS, Swenson R, Kiesewetter DO, Backus KM, Geng Y, Raj R, Anthony DC, Flynn JL, Barry CE, Davis BG. PMID: 38937448; PMCID: PMC11211441.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    7. Chemoproteomics Identifies State-Dependent and Proteoform-Selective Caspase-2 Inhibitors. J Am Chem Soc. 2024 Jun 05; 146(22):14972-14988. Castellón JO, Ofori S, Burton NR, Julio AR, Turmon AC, Armenta E, Sandoval C, Boatner LM, Takayoshi EE, Faragalla M, Taylor C, Zhou AL, Tran K, Shek J, Yan T, Desai HS, Fregoso OI, Damoiseaux R, Backus KM. PMID: 38787738.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    8. Functionalizing tandem mass tags for streamlining click-based quantitative chemoproteomics. Commun Chem. 2024 Apr 10; 7(1):80. Burton NR, Backus KM. PMID: 38600184; PMCID: PMC11006884.
      View in: PubMed   Mentions:
    9. Protocol for organelle-specific cysteine capture and quantification of cysteine oxidation state. STAR Protoc. 2024 Mar 15; 5(1):102865. Julio AR, Yan T, Backus KM. PMID: 38329879; PMCID: PMC10862403.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    10. Defining the Cell Surface Cysteinome Using Two-Step Enrichment Proteomics. JACS Au. 2023 Dec 25; 3(12):3506-3523. Yan T, Boatner LM, Cui L, Tontonoz PJ, Backus KM. PMID: 38155636; PMCID: PMC10751780.
      View in: PubMed   Mentions: 3  
    11. Pervasive aggregation and depletion of host and viral proteins in response to cysteine-reactive electrophilic compounds. bioRxiv. 2023 Nov 16. Julio AR, Shikwana F, Truong C, Burton NR, Dominguez E, Turmon AC, Cao J, Backus K. PMID: 38014036; PMCID: PMC10680658.
      View in: PubMed   Mentions:
    12. Chemoproteomics identifies proteoform-selective caspase-2 inhibitors. bioRxiv. 2023 Oct 26. Castellón JO, Ofori S, Armenta E, Burton N, Boatner LM, Takayoshi EE, Faragalla M, Zhou A, Tran K, Shek J, Yan T, Desai HS, Backus KM. PMID: 37961563; PMCID: PMC10634807.
      View in: PubMed   Mentions:
    13. Defining the Cell Surface Cysteinome using Two-step Enrichment Proteomics. bioRxiv. 2023 Oct 19. Yan T, Boatner LM, Cui L, Tontonoz P, Backus KM. PMID: 37904933; PMCID: PMC10614875.
      View in: PubMed   Mentions:
    14. Solid-Phase Compatible Silane-Based Cleavable Linker Enables Custom Isobaric Quantitative Chemoproteomics. J Am Chem Soc. 2023 10 04; 145(39):21303-21318. Burton NR, Polasky DA, Shikwana F, Ofori S, Yan T, Geiszler DJ, Veiga Leprevost FD, Nesvizhskii AI, Backus KM. PMID: 37738129.
      View in: PubMed   Mentions: 2     Fields:    
    15. Multi-omic stratification of the missense variant cysteinome. bioRxiv. 2023 Aug 14. Desai H, Ofori S, Boatner L, Yu F, Villanueva M, Ung N, Nesvizhskii AI, Backus K. PMID: 37645963; PMCID: PMC10461992.
      View in: PubMed   Mentions:
    16. Proximity-labeling chemoproteomics defines the subcellular cysteinome and inflammation-responsive mitochondrial redoxome. Cell Chem Biol. 2023 07 20; 30(7):811-827.e7. Yan T, Julio AR, Villanueva M, Jones AE, Ball AB, Boatner LM, Turmon AC, Nguy?n KB, Yen SL, Desai HS, Divakaruni AS, Backus KM. PMID: 37419112; PMCID: PMC10510412.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    17. CysDB: a human cysteine database based on experimental quantitative chemoproteomics. Cell Chem Biol. 2023 06 15; 30(6):683-698.e3. Boatner LM, Palafox MF, Schweppe DK, Backus KM. PMID: 37119813; PMCID: PMC10510411.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    18. Distributable, Metabolic PET Reporting of Tuberculosis. bioRxiv. 2023 Apr 03. Naseer Khan RM, Ahn YM, Marriner GA, Via LE, D'Hooge F, Lee SS, Yang N, Basuli F, White AG, Tomko JA, Frye LJ, Scanga CA, Weiner DM, Sutphen ML, Schimel DM, Dayao E, Piazza MK, Gomez F, Dieckmann W, Herscovitch P, Mason NS, Swenson R, Kiesewetter DO, Backus KM, Geng Y, Raj R, Anthony DC, Flynn JL, Barry CE, Davis BG. PMID: 37333343; PMCID: PMC10274857.
      View in: PubMed   Mentions:
    19. Proximity-labeling chemoproteomics defines the subcellular cysteinome and inflammation-responsive mitochondrial redoxome. bioRxiv. 2023 Jan 31. Yan T, Julio AR, Villanueva M, Jones AE, Ball AB, Boatner LM, Turmon AC, Yen SL, Desai HS, Divakaruni AS, Backus KM. PMID: 36711448; PMCID: PMC9882296.
      View in: PubMed   Mentions:
    20. Introduction to the themed collection on Covalent Drug Discovery. RSC Med Chem. 2022 Aug 17; 13(8):893-894. Backus KM, Pan Z, Jones LH. PMID: 36092145; PMCID: PMC9384831.
      View in: PubMed   Mentions:
    21. SP3-FAIMS-Enabled High-Throughput Quantitative Profiling of the Cysteinome. Curr Protoc. 2022 Jul; 2(7):e492. Desai HS, Yan T, Backus KM. PMID: 35895291.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    22. SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 04; 21(4):100218. Desai HS, Yan T, Yu F, Sun AW, Villanueva M, Nesvizhskii AI, Backus KM. PMID: 35219905; PMCID: PMC9010637.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    23. Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 03 08; 94(9):3800-3810. Yan T, Palmer AB, Geiszler DJ, Polasky DA, Boatner LM, Burton NR, Armenta E, Nesvizhskii AI, Backus KM. PMID: 35195394.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    24. Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26; 61(5):e202112107. Tang KC, Cao J, Boatner LM, Li L, Farhi J, Houk KN, Spangle J, Backus KM, Raj M. PMID: 34762358; PMCID: PMC10111338.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    25. Tunable heteroaromatic azoline thioethers (HATs) for cysteine profiling. Chem Sci. 2022 Jan 19; 13(3):763-774. Tang KC, Maddox SM, Backus KM, Raj M. PMID: 35173941; PMCID: PMC8768877.
      View in: PubMed   Mentions: 6  
    26. Photoaffinity labelling strategies for mapping the small molecule-protein interactome. Org Biomol Chem. 2021 Sep 22; 19(36):7792-7809. Burton NR, Kim P, Backus KM. PMID: 34549230; PMCID: PMC8489259.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    27. SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 05 14; 22(10):1841-1851. Yan T, Desai HS, Boatner LM, Yen SL, Cao J, Palafox MF, Jami-Alahmadi Y, Backus KM. PMID: 33442901; PMCID: PMC8942723.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    28. From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 02; 17(2):e9840. Palafox MF, Desai HS, Arboleda VA, Backus KM. PMID: 33599394; PMCID: PMC7890448.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    29. New approaches to target RNA binding proteins. Curr Opin Chem Biol. 2021 06; 62:13-23. Julio AR, Backus KM. PMID: 33535093; PMCID: PMC8823266.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    30. Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 02 02; 93(4):2610-2618. Cao J, Boatner LM, Desai HS, Burton NR, Armenta E, Chan NJ, Castellón JO, Backus KM. PMID: 33470097; PMCID: PMC8849040.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    31. Integrative X-ray Structure and Molecular Modeling for the Rationalization of Procaspase-8 Inhibitor Potency and Selectivity. ACS Chem Biol. 2020 02 21; 15(2):575-586. Xu JH, Eberhardt J, Hill-Payne B, González-Páez GE, Castellón JO, Cravatt BF, Forli S, Wolan DW, Backus KM. PMID: 31927936; PMCID: PMC7370820.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    32. Opportunities and challenges for the development of covalent chemical immunomodulators. Bioorg Med Chem. 2019 08 01; 27(15):3421-3439. Backus KM, Cao J, Maddox SM. PMID: 31204229.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    33. Applications of Reactive Cysteine Profiling. Curr Top Microbiol Immunol. 2019; 420:375-417. Backus KM. PMID: 30105421.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    34. Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer. Cell. 2017 Oct 19; 171(3):696-709.e23. Bar-Peled L, Kemper EK, Suciu RM, Vinogradova EV, Backus KM, Horning BD, Paul TA, Ichu TA, Svensson RU, Olucha J, Chang MW, Kok BP, Zhu Z, Ihle NT, Dix MM, Jiang P, Hayward MM, Saez E, Shaw RJ, Cravatt BF. PMID: 28965760; PMCID: PMC5728659.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansCells
    35. Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 12; 9(12):1181-1190. Hacker SM, Backus KM, Lazear MR, Forli S, Correia BE, Cravatt BF. PMID: 29168484; PMCID: PMC5726523.
      View in: PubMed   Mentions: 140     Fields:    Translation:Humans
    36. A Screen for Protein-Protein Interactions in Live Mycobacteria Reveals a Functional Link between the Virulence-Associated Lipid Transporter LprG and the Mycolyltransferase Antigen 85A. ACS Infect Dis. 2017 05 12; 3(5):336-348. Touchette MH, Van Vlack ER, Bai L, Kim J, Cognetta AB, Previti ML, Backus KM, Martin DW, Cravatt BF, Seeliger JC. PMID: 28276676; PMCID: PMC5632815.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    37. Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases. Cell. 2017 01 26; 168(3):517-526.e18. Guo CJ, Chang FY, Wyche TP, Backus KM, Acker TM, Funabashi M, Taketani M, Donia MS, Nayfach S, Pollard KS, Craik CS, Cravatt BF, Clardy J, Voigt CA, Fischbach MA. PMID: 28111075; PMCID: PMC5302092.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    38. Covalent Modulators of the Vacuolar ATPase. J Am Chem Soc. 2017 01 18; 139(2):639-642. Chen YC, Backus KM, Merkulova M, Yang C, Brown D, Cravatt BF, Zhang C. PMID: 28010062; PMCID: PMC5274637.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    39. Chemical Proteomic Profiling of Human Methyltransferases. J Am Chem Soc. 2016 10 12; 138(40):13335-13343. Horning BD, Suciu RM, Ghadiri DA, Ulanovskaya OA, Matthews ML, Lum KM, Backus KM, Brown SJ, Rosen H, Cravatt BF. PMID: 27689866; PMCID: PMC5072128.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    40. Chemical proteomic map of dimethyl fumarate-sensitive cysteines in primary human T cells. Sci Signal. 2016 09 13; 9(445):rs10. Blewett MM, Xie J, Zaro BW, Backus KM, Altman A, Teijaro JR, Cravatt BF. PMID: 27625306; PMCID: PMC5068918.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    41. Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine. Cell. 2016 Jun 30; 166(1):126-39. Briggs KJ, Koivunen P, Cao S, Backus KM, Olenchock BA, Patel H, Zhang Q, Signoretti S, Gerfen GJ, Richardson AL, Witkiewicz AK, Cravatt BF, Clardy J, Kaelin WG. PMID: 27368101; PMCID: PMC4930557.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansAnimalsCells
    42. Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 06 23; 534(7608):570-4. Backus KM, Correia BE, Lum KM, Forli S, Horning BD, González-Páez GE, Chatterjee S, Lanning BR, Teijaro JR, Olson AJ, Wolan DW, Cravatt BF. PMID: 27309814; PMCID: PMC4919207.
      View in: PubMed   Mentions: 328     Fields:    Translation:HumansCells
    43. The three Mycobacterium tuberculosis antigen 85 isoforms have unique substrates and activities determined by non-active site regions. J Biol Chem. 2014 Sep 05; 289(36):25041-53. Backus KM, Dolan MA, Barry CS, Joe M, McPhie P, Boshoff HI, Lowary TL, Davis BG, Barry CE. PMID: 25028517; PMCID: PMC4155671.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    44. ESI-MS assay of M. tuberculosis cell wall antigen 85 enzymes permits substrate profiling and design of a mechanism-based inhibitor. J Am Chem Soc. 2011 Aug 31; 133(34):13232-5. Barry CS, Backus KM, Barry CE, Davis BG. PMID: 21776980; PMCID: PMC11042539.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    45. Uptake of unnatural trehalose analogs as a reporter for Mycobacterium tuberculosis. Nat Chem Biol. 2011 Apr; 7(4):228-35. Backus KM, Boshoff HI, Barry CS, Boutureira O, Patel MK, D'Hooge F, Lee SS, Via LE, Tahlan K, Barry CE, Davis BG. PMID: 21378984; PMCID: PMC3157484.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
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