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Keriann Marie Backus

Title(s)Assistant Professor, Biological Chemistry
SchoolMedicine
Address760 Westwood Plaza 337
Los Angeles CA 90024
Phone3102068617
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    Collapse Research 
    Collapse Research Activities and Funding
    Fragment-Based Ligand Discovery in Proteomes
    NIH/NIGMS F32GM108208Jul 1, 2013 - Jun 30, 2015
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Integrative X-ray Structure and Molecular Modeling for the Rationalization of Procaspase-8 Inhibitor Potency and Selectivity. ACS Chem Biol. 2020 02 21; 15(2):575-586. Xu JH, Eberhardt J, Hill-Payne B, González-Páez GE, Castellón JO, Cravatt BF, Forli S, Wolan DW, Backus KM. PMID: 31927936.
      View in: PubMed   Mentions:    Fields:    
    2. Opportunities and challenges for the development of covalent chemical immunomodulators. Bioorg Med Chem. 2019 08 01; 27(15):3421-3439. Backus KM, Cao J, Maddox SM. PMID: 31204229.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    3. Applications of Reactive Cysteine Profiling. Curr Top Microbiol Immunol. 2019; 420:375-417. Backus KM. PMID: 30105421.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    4. Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer. Cell. 2017 Oct 19; 171(3):696-709.e23. Bar-Peled L, Kemper EK, Suciu RM, Vinogradova EV, Backus KM, Horning BD, Paul TA, Ichu TA, Svensson RU, Olucha J, Chang MW, Kok BP, Zhu Z, Ihle NT, Dix MM, Jiang P, Hayward MM, Saez E, Shaw RJ, Cravatt BF. PMID: 28965760.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    5. Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 12; 9(12):1181-1190. Hacker SM, Backus KM, Lazear MR, Forli S, Correia BE, Cravatt BF. PMID: 29168484.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    6. A Screen for Protein-Protein Interactions in Live Mycobacteria Reveals a Functional Link between the Virulence-Associated Lipid Transporter LprG and the Mycolyltransferase Antigen 85A. ACS Infect Dis. 2017 05 12; 3(5):336-348. Touchette MH, Van Vlack ER, Bai L, Kim J, Cognetta AB, Previti ML, Backus KM, Martin DW, Cravatt BF, Seeliger JC. PMID: 28276676.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    7. Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases. Cell. 2017 01 26; 168(3):517-526.e18. Guo CJ, Chang FY, Wyche TP, Backus KM, Acker TM, Funabashi M, Taketani M, Donia MS, Nayfach S, Pollard KS, Craik CS, Cravatt BF, Clardy J, Voigt CA, Fischbach MA. PMID: 28111075.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    8. Covalent Modulators of the Vacuolar ATPase. J Am Chem Soc. 2017 01 18; 139(2):639-642. Chen YC, Backus KM, Merkulova M, Yang C, Brown D, Cravatt BF, Zhang C. PMID: 28010062.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    9. Chemical Proteomic Profiling of Human Methyltransferases. J Am Chem Soc. 2016 10 12; 138(40):13335-13343. Horning BD, Suciu RM, Ghadiri DA, Ulanovskaya OA, Matthews ML, Lum KM, Backus KM, Brown SJ, Rosen H, Cravatt BF. PMID: 27689866.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    10. Chemical proteomic map of dimethyl fumarate-sensitive cysteines in primary human T cells. Sci Signal. 2016 09 13; 9(445):rs10. Blewett MM, Xie J, Zaro BW, Backus KM, Altman A, Teijaro JR, Cravatt BF. PMID: 27625306.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    11. Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine. Cell. 2016 Jun 30; 166(1):126-39. Briggs KJ, Koivunen P, Cao S, Backus KM, Olenchock BA, Patel H, Zhang Q, Signoretti S, Gerfen GJ, Richardson AL, Witkiewicz AK, Cravatt BF, Clardy J, Kaelin WG. PMID: 27368101.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    12. Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 06 23; 534(7608):570-4. Backus KM, Correia BE, Lum KM, Forli S, Horning BD, González-Páez GE, Chatterjee S, Lanning BR, Teijaro JR, Olson AJ, Wolan DW, Cravatt BF. PMID: 27309814.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    13. The three Mycobacterium tuberculosis antigen 85 isoforms have unique substrates and activities determined by non-active site regions. J Biol Chem. 2014 Sep 05; 289(36):25041-53. Backus KM, Dolan MA, Barry CS, Joe M, McPhie P, Boshoff HI, Lowary TL, Davis BG, Barry CE. PMID: 25028517.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    14. ESI-MS assay of M. tuberculosis cell wall antigen 85 enzymes permits substrate profiling and design of a mechanism-based inhibitor. J Am Chem Soc. 2011 Aug 31; 133(34):13232-5. Barry CS, Backus KM, Barry CE, Davis BG. PMID: 21776980.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    15. Uptake of unnatural trehalose analogs as a reporter for Mycobacterium tuberculosis. Nat Chem Biol. 2011 Apr; 7(4):228-35. Backus KM, Boshoff HI, Barry CS, Boutureira O, Patel MK, D'Hooge F, Lee SS, Via LE, Tahlan K, Barry CE, Davis BG. PMID: 21378984.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
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