Yvonne Yu-Hsuan Chen

Title(s)Professor, MIMG
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    Stanford University, Stanford, CaliforniaBS06/2004Chemical Engineering
    California Institute of Technology, Pasadena, CAPhD12/2010Chemical Engineering
    Harvard Medical School, Boston, MAPostdoc06/2013Systems Biology

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. IL-13Rα2/TGF-β bispecific CAR-T cells counter TGF-β-mediated immune suppression and potentiate anti-tumor responses in glioblastoma. Neuro Oncol. 2024 Jul 10. Hou AJ, Shih RM, Uy BR, Shafer A, Chang ZNL, Comin-Anduix B, Guemes M, Galic Z, Phyu S, Okada H, Grausam KB, Breunig JJ, Brown CE, Nathanson DA, Prins RM, Chen YY. PMID: 38982561.
      View in: PubMed   Mentions:
    2. Extracellular domains of CARs reprogramme T cell metabolism without antigen stimulation. Nat Metab. 2024 Jun; 6(6):1143-1160. Lakhani A, Chen X, Chen LC, Hong M, Khericha M, Chen Y, Chen YY, Park JO. PMID: 38658805.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    3. Self-regulating CAR-T cells modulate cytokine release syndrome in adoptive T-cell therapy. J Exp Med. 2024 Jun 03; 221(6). Lin MY, Nam E, Shih RM, Shafer A, Bouren A, Ayala Ceja M, Harris C, Khericha M, Vo KH, Kim M, Tseng CH, Chen YY. PMID: 38607370; PMCID: PMC11010356.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    4. CAR-T cell manufacturing: Major process parameters and next-generation strategies. J Exp Med. 2024 Feb 05; 221(2). Ayala Ceja M, Khericha M, Harris CM, Puig-Saus C, Chen YY. PMID: 38226974; PMCID: PMC10791545.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    5. Advances in promoting chimeric antigen receptor T cell trafficking and infiltration of solid tumors. Curr Opin Biotechnol. 2023 Dec; 84:103020. Hong M, Talluri S, Chen YY. PMID: 37976958.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    6. Successes and challenges in clinical gene therapy. Gene Ther. 2023 Nov; 30(10-11):738-746. Kohn DB, Chen YY, Spencer MJ. PMID: 37935854; PMCID: PMC10678346.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    7. Synthetic Biology in the Engineering of CAR-T and CAR-NK Cell Therapies: Facts and Hopes. Clin Cancer Res. 2023 04 14; 29(8):1390-1402. Clubb JD, Gao TA, Chen YY. PMID: 36454122; PMCID: PMC10106357.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    8. Extracellular Domains of CAR Reprogram T-Cell Metabolism Without Antigen Stimulation. bioRxiv. 2023 Apr 04. Lakhani A, Chen X, Chen LC, Khericha M, Chen YY, Park JO. PMID: 37066394; PMCID: PMC10103977.
      View in: PubMed   Mentions:
    9. CD19/CD20 Bispecific Chimeric Antigen Receptor (CAR) in Naive/Memory T Cells for the Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma. Cancer Discov. 2023 03 01; 13(3):580-597. Larson SM, Walthers CM, Ji B, Ghafouri SN, Naparstek J, Trent J, Chen JM, Roshandell M, Harris C, Khericha M, Schweppe T, Berent-Maoz B, Gosliner SB, Almaktari A, Ceja MA, Allen-Auerbach MS, Said J, Nawaly K, Mead M, de Vos S, Young PA, Oliai C, Schiller GJ, Timmerman JM, Ribas A, Chen YY. PMID: 36416874; PMCID: PMC9992104.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    10. Rational Protein Design Yields a CD20 CAR with Superior Antitumor Efficacy Compared with CD19 CAR. Cancer Immunol Res. 2023 02 03; 11(2):150-163. Chen X, Chen LC, Khericha M, Meng X, Salvestrini E, Shafer A, Iyer N, Alag AS, Ding Y, Nicolaou DM, Chen YY. PMID: 36409926; PMCID: PMC9898126.
      View in: PubMed   Mentions: 4     Fields:    
    11. The sound of silence: Transgene silencing in mammalian cell engineering. Cell Syst. 2022 12 21; 13(12):950-973. Cabrera A, Edelstein HI, Glykofrydis F, Love KS, Palacios S, Tycko J, Zhang M, Lensch S, Shields CE, Livingston M, Weiss R, Zhao H, Haynes KA, Morsut L, Chen YY, Khalil AS, Wong WW, Collins JJ, Rosser SJ, Polizzi K, Elowitz MB, Fussenegger M, Hilton IB, Leonard JN, Bintu L, Galloway KE, Deans TL. PMID: 36549273; PMCID: PMC9880859.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    12. Engineering Next-Generation CAR-T Cells: Overcoming Tumor Hypoxia and Metabolism. Annu Rev Chem Biomol Eng. 2022 06 10; 13:193-216. Gao TA, Chen YY. PMID: 35700528.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    13. T cells to fix a broken heart. Science. 2022 Jan 07; 375(6576):23-24. Gao TA, Chen YY. PMID: 34990255.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    14. Engineering Principles for Synthetic Biology Circuits in Cancer Immunotherapy. Cancer Immunol Res. 2022 01; 10(1):6-11. Shih RM, Chen YY. PMID: 34983828.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    15. Killer fatigue: Transition to NK-cell-like phenotype is a signature of CAR-T cell exhaustion. Cell. 2021 12 09; 184(25):6017-6019. Hong M, Chen YY. PMID: 34890549.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    16. Getting better mileage with logically primed CARs. Med (N Y). 2021 07 09; 2(7):785-787. Chen LC, Hou AJ, Chen YY. PMID: 35590214.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    17. Navigating CAR-T cells through the solid-tumour microenvironment. Nat Rev Drug Discov. 2021 07; 20(7):531-550. Hou AJ, Chen LC, Chen YY. PMID: 33972771.
      View in: PubMed   Mentions: 155     Fields:    Translation:HumansAnimalsCells
    18. What is the Optimal Design-Build-Test Cycle for Clinically Relevant Synthetic CAR T Cell Therapies? Cell Syst. 2020 09 23; 11(3):212-214. Chen YY, Lim W, Levings M, Blazar B, Krenciute G, Wong W, Lehner M. PMID: 32970992; PMCID: PMC7861890.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. A Fresh Approach to Targeting Aging Cells: CAR-T Cells Enhance Senolytic Specificity. Cell Stem Cell. 2020 08 06; 27(2):192-194. Li JH, Chen YY. PMID: 32763179; PMCID: PMC7717659.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    20. Engineering CAR-T Cells for Next-Generation Cancer Therapy. Cancer Cell. 2020 10 12; 38(4):473-488. Hong M, Clubb JD, Chen YY. PMID: 32735779.
      View in: PubMed   Mentions: 198     Fields:    Translation:HumansAnimalsCells
    21. CAR-T design: Elements and their synergistic function. EBioMedicine. 2020 Aug; 58:102931. Jayaraman J, Mellody MP, Hou AJ, Desai RP, Fung AW, Pham AHT, Chen YY, Zhao W. PMID: 32739874; PMCID: PMC7393540.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansCells
    22. Systematically optimized BCMA/CS1 bispecific CAR-T cells robustly control heterogeneous multiple myeloma. Nat Commun. 2020 05 08; 11(1):2283. Zah E, Nam E, Bhuvan V, Tran U, Ji BY, Gosliner SB, Wang X, Brown CE, Chen YY. PMID: 32385241; PMCID: PMC7210316.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansCells
    23. Engineering primary T cells with chimeric antigen receptors for rewired responses to soluble ligands. Nat Protoc. 2020 04; 15(4):1507-1524. Chang ZL, Hou AJ, Chen YY. PMID: 32103205; PMCID: PMC7430204.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    24. Editorial overview: Pharmaceutical biotechnology: new frontiers in protein, gene, and cell therapies. Curr Opin Biotechnol. 2019 12; 60:iii-v. Chen YY, Van Deventer JA. PMID: 31690473.
      View in: PubMed   Mentions:    Fields:    
    25. Cell fishing with DNA aptamers. Nat Biomed Eng. 2019 10; 3(10):757-758. Chen YY. PMID: 31591522.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    26. Outsmarting and outmuscling cancer cells with synthetic and systems immunology. Curr Opin Biotechnol. 2019 12; 60:111-118. Chen LC, Chen YY. PMID: 30822698.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    27. TGF-β-responsive CAR-T cells promote anti-tumor immune function. Bioeng Transl Med. 2018 May; 3(2):75-86. Hou AJ, Chang ZL, Lorenzini MH, Zah E, Chen YY. PMID: 30065964; PMCID: PMC6063867.
      View in: PubMed   Mentions: 41  
    28. Synthetic biology advances and applications in the biotechnology industry: a perspective. J Ind Microbiol Biotechnol. 2018 Jul; 45(7):449-461. Katz L, Chen YY, Gonzalez R, Peterson TC, Zhao H, Baltz RH. PMID: 29915997.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    29. Increasing T Cell Versatility with SUPRA CARs. Cell. 2018 05 31; 173(6):1316-1317. Chen YY. PMID: 29856949.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    30. Rewiring T-cell responses to soluble factors with chimeric antigen receptors. Nat Chem Biol. 2018 03; 14(3):317-324. Chang ZL, Lorenzini MH, Chen X, Tran U, Bangayan NJ, Chen YY. PMID: 29377003; PMCID: PMC6035732.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansCells
    31. Mammalian synthetic biology in the age of genome editing and personalized medicine. Curr Opin Chem Biol. 2017 Oct; 40:57-64. Ho P, Chen YY. PMID: 28628856; PMCID: PMC5696019.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    32. Modularly Constructed Synthetic Granzyme B Molecule Enables Interrogation of Intracellular Proteases for Targeted Cytotoxicity. ACS Synth Biol. 2017 08 18; 6(8):1484-1495. Ho P, Ede C, Chen YY. PMID: 28510446; PMCID: PMC5683712.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    33. CARs: Synthetic Immunoreceptors for Cancer Therapy and Beyond. Trends Mol Med. 2017 05; 23(5):430-450. Chang ZL, Chen YY. PMID: 28416139; PMCID: PMC5423782.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    34. ADDENDUM: T Cells Expressing CD19/CD20 Bispecific Chimeric Antigen Receptors Prevent Antigen Escape by Malignant B Cells. Cancer Immunol Res. 2016 07; 4(7):639-41. Zah E, Lin MY, Silva-Benedict A, Jensen MC, Chen YY. PMID: 27371639; PMCID: PMC4943870.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    35. T Cells Expressing CD19/CD20 Bispecific Chimeric Antigen Receptors Prevent Antigen Escape by Malignant B Cells. Cancer Immunol Res. 2016 06; 4(6):498-508. Zah E, Lin MY, Silva-Benedict A, Jensen MC, Chen YY. PMID: 27059623; PMCID: PMC4933590.
      View in: PubMed   Mentions: 279     Fields:    Translation:HumansAnimalsCells
    36. Quantitative Analyses of Core Promoters Enable Precise Engineering of Regulated Gene Expression in Mammalian Cells. ACS Synth Biol. 2016 05 20; 5(5):395-404. Ede C, Chen X, Lin MY, Chen YY. PMID: 26883397; PMCID: PMC4874895.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    37. Efficient Gene Editing in Primary Human T Cells. Trends Immunol. 2015 Nov; 36(11):667-669. Chen YY. PMID: 26440702.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    38. Identification and selective expansion of functionally superior T cells expressing chimeric antigen receptors. J Transl Med. 2015 May 20; 13:161. Chang ZL, Silver PA, Chen YY. PMID: 25990251; PMCID: PMC4457995.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    39. Synthetic biology: advancing biological frontiers by building synthetic systems. Genome Biol. 2012 Feb 20; 13(2):240. Chen YY, Galloway KE, Smolke CD. PMID: 22348749; PMCID: PMC3334564.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    40. From DNA to targeted therapeutics: bringing synthetic biology to the clinic. Sci Transl Med. 2011 Oct 26; 3(106):106ps42. Chen YY, Smolke CD. PMID: 22030748; PMCID: PMC3285276.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    41. Design of small molecule-responsive microRNAs based on structural requirements for Drosha processing. Nucleic Acids Res. 2011 Apr; 39(7):2981-94. Beisel CL, Chen YY, Culler SJ, Hoff KG, Smolke CD. PMID: 21149259; PMCID: PMC3074164.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    42. Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems. Proc Natl Acad Sci U S A. 2010 May 11; 107(19):8531-6. Chen YY, Jensen MC, Smolke CD. PMID: 20421500; PMCID: PMC2889348.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansAnimalsCells
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