Yvonne Yu-Hsuan Chen

Title(s)Professor, MIMG
SchoolMedicine
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    Stanford University, Stanford, CaliforniaBS06/2004Chemical Engineering
    California Institute of Technology, Pasadena, CAPhD12/2010Chemical Engineering
    Harvard Medical School, Boston, MAPostdoc06/2013Systems Biology

    Collapse Overview 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Self-regulating CAR-T cells modulate cytokine release syndrome in adoptive T-cell therapy. J Exp Med. 2024 Jun 03; 221(6). Lin MY, Nam E, Shih RM, Shafer A, Bouren A, Ayala Ceja M, Harris C, Khericha M, Vo KH, Kim M, Tseng CH, Chen YY. PMID: 38607370; PMCID: PMC11010356.
      View in: PubMed   Mentions:
    2. CAR-T cell manufacturing: Major process parameters and next-generation strategies. J Exp Med. 2024 Feb 05; 221(2). Ayala Ceja M, Khericha M, Harris CM, Puig-Saus C, Chen YY. PMID: 38226974; PMCID: PMC10791545.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Advances in promoting chimeric antigen receptor T cell trafficking and infiltration of solid tumors. Curr Opin Biotechnol. 2023 Dec; 84:103020. Hong M, Talluri S, Chen YY. PMID: 37976958.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    4. Successes and challenges in clinical gene therapy. Gene Ther. 2023 Nov; 30(10-11):738-746. Kohn DB, Chen YY, Spencer MJ. PMID: 37935854; PMCID: PMC10678346.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Synthetic Biology in the Engineering of CAR-T and CAR-NK Cell Therapies: Facts and Hopes. Clin Cancer Res. 2023 04 14; 29(8):1390-1402. Clubb JD, Gao TA, Chen YY. PMID: 36454122; PMCID: PMC10106357.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    6. Extracellular Domains of CAR Reprogram T-Cell Metabolism Without Antigen Stimulation. bioRxiv. 2023 Apr 04. Lakhani A, Chen X, Chen LC, Khericha M, Chen YY, Park JO. PMID: 37066394; PMCID: PMC10103977.
      View in: PubMed   Mentions:
    7. CD19/CD20 Bispecific Chimeric Antigen Receptor (CAR) in Naive/Memory T Cells for the Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma. Cancer Discov. 2023 03 01; 13(3):580-597. Larson SM, Walthers CM, Ji B, Ghafouri SN, Naparstek J, Trent J, Chen JM, Roshandell M, Harris C, Khericha M, Schweppe T, Berent-Maoz B, Gosliner SB, Almaktari A, Ceja MA, Allen-Auerbach MS, Said J, Nawaly K, Mead M, de Vos S, Young PA, Oliai C, Schiller GJ, Timmerman JM, Ribas A, Chen YY. PMID: 36416874; PMCID: PMC9992104.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    8. Rational Protein Design Yields a CD20 CAR with Superior Antitumor Efficacy Compared with CD19 CAR. Cancer Immunol Res. 2023 02 03; 11(2):150-163. Chen X, Chen LC, Khericha M, Meng X, Salvestrini E, Shafer A, Iyer N, Alag AS, Ding Y, Nicolaou DM, Chen YY. PMID: 36409926; PMCID: PMC9898126.
      View in: PubMed   Mentions: 2     Fields:    
    9. The sound of silence: Transgene silencing in mammalian cell engineering. Cell Syst. 2022 12 21; 13(12):950-973. Cabrera A, Edelstein HI, Glykofrydis F, Love KS, Palacios S, Tycko J, Zhang M, Lensch S, Shields CE, Livingston M, Weiss R, Zhao H, Haynes KA, Morsut L, Chen YY, Khalil AS, Wong WW, Collins JJ, Rosser SJ, Polizzi K, Elowitz MB, Fussenegger M, Hilton IB, Leonard JN, Bintu L, Galloway KE, Deans TL. PMID: 36549273; PMCID: PMC9880859.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    10. Engineering Next-Generation CAR-T Cells: Overcoming Tumor Hypoxia and Metabolism. Annu Rev Chem Biomol Eng. 2022 06 10; 13:193-216. Gao TA, Chen YY. PMID: 35700528.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    11. T cells to fix a broken heart. Science. 2022 Jan 07; 375(6576):23-24. Gao TA, Chen YY. PMID: 34990255.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    12. Engineering Principles for Synthetic Biology Circuits in Cancer Immunotherapy. Cancer Immunol Res. 2022 01; 10(1):6-11. Shih RM, Chen YY. PMID: 34983828.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    13. Killer fatigue: Transition to NK-cell-like phenotype is a signature of CAR-T cell exhaustion. Cell. 2021 12 09; 184(25):6017-6019. Hong M, Chen YY. PMID: 34890549.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    14. Getting better mileage with logically primed CARs. Med (N Y). 2021 07 09; 2(7):785-787. Chen LC, Hou AJ, Chen YY. PMID: 35590214.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    15. Navigating CAR-T cells through the solid-tumour microenvironment. Nat Rev Drug Discov. 2021 07; 20(7):531-550. Hou AJ, Chen LC, Chen YY. PMID: 33972771.
      View in: PubMed   Mentions: 144     Fields:    Translation:HumansAnimalsCells
    16. What is the Optimal Design-Build-Test Cycle for Clinically Relevant Synthetic CAR T Cell Therapies? Cell Syst. 2020 09 23; 11(3):212-214. Chen YY, Lim W, Levings M, Blazar B, Krenciute G, Wong W, Lehner M. PMID: 32970992; PMCID: PMC7861890.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. A Fresh Approach to Targeting Aging Cells: CAR-T Cells Enhance Senolytic Specificity. Cell Stem Cell. 2020 08 06; 27(2):192-194. Li JH, Chen YY. PMID: 32763179; PMCID: PMC7717659.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    18. CAR-T design: Elements and their synergistic function. EBioMedicine. 2020 Aug; 58:102931. Jayaraman J, Mellody MP, Hou AJ, Desai RP, Fung AW, Pham AHT, Chen YY, Zhao W. PMID: 32739874; PMCID: PMC7393540.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansCells
    19. Engineering CAR-T Cells for Next-Generation Cancer Therapy. Cancer Cell. 2020 10 12; 38(4):473-488. Hong M, Clubb JD, Chen YY. PMID: 32735779.
      View in: PubMed   Mentions: 192     Fields:    Translation:HumansAnimalsCells
    20. Systematically optimized BCMA/CS1 bispecific CAR-T cells robustly control heterogeneous multiple myeloma. Nat Commun. 2020 05 08; 11(1):2283. Zah E, Nam E, Bhuvan V, Tran U, Ji BY, Gosliner SB, Wang X, Brown CE, Chen YY. PMID: 32385241; PMCID: PMC7210316.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansCells
    21. Engineering primary T cells with chimeric antigen receptors for rewired responses to soluble ligands. Nat Protoc. 2020 04; 15(4):1507-1524. Chang ZL, Hou AJ, Chen YY. PMID: 32103205; PMCID: PMC7430204.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    22. Editorial overview: Pharmaceutical biotechnology: new frontiers in protein, gene, and cell therapies. Curr Opin Biotechnol. 2019 12; 60:iii-v. Chen YY, Van Deventer JA. PMID: 31690473.
      View in: PubMed   Mentions:    Fields:    
    23. Cell fishing with DNA aptamers. Nat Biomed Eng. 2019 10; 3(10):757-758. Chen YY. PMID: 31591522.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    24. Outsmarting and outmuscling cancer cells with synthetic and systems immunology. Curr Opin Biotechnol. 2019 12; 60:111-118. Chen LC, Chen YY. PMID: 30822698.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    25. TGF-β-responsive CAR-T cells promote anti-tumor immune function. Bioeng Transl Med. 2018 May; 3(2):75-86. Hou AJ, Chang ZL, Lorenzini MH, Zah E, Chen YY. PMID: 30065964; PMCID: PMC6063867.
      View in: PubMed   Mentions: 37  
    26. Synthetic biology advances and applications in the biotechnology industry: a perspective. J Ind Microbiol Biotechnol. 2018 Jul; 45(7):449-461. Katz L, Chen YY, Gonzalez R, Peterson TC, Zhao H, Baltz RH. PMID: 29915997.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    27. Increasing T Cell Versatility with SUPRA CARs. Cell. 2018 05 31; 173(6):1316-1317. Chen YY. PMID: 29856949.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    28. Rewiring T-cell responses to soluble factors with chimeric antigen receptors. Nat Chem Biol. 2018 03; 14(3):317-324. Chang ZL, Lorenzini MH, Chen X, Tran U, Bangayan NJ, Chen YY. PMID: 29377003; PMCID: PMC6035732.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansCells
    29. Mammalian synthetic biology in the age of genome editing and personalized medicine. Curr Opin Chem Biol. 2017 Oct; 40:57-64. Ho P, Chen YY. PMID: 28628856; PMCID: PMC5696019.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    30. Modularly Constructed Synthetic Granzyme B Molecule Enables Interrogation of Intracellular Proteases for Targeted Cytotoxicity. ACS Synth Biol. 2017 08 18; 6(8):1484-1495. Ho P, Ede C, Chen YY. PMID: 28510446; PMCID: PMC5683712.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    31. CARs: Synthetic Immunoreceptors for Cancer Therapy and Beyond. Trends Mol Med. 2017 05; 23(5):430-450. Chang ZL, Chen YY. PMID: 28416139; PMCID: PMC5423782.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    32. ADDENDUM: T Cells Expressing CD19/CD20 Bispecific Chimeric Antigen Receptors Prevent Antigen Escape by Malignant B Cells. Cancer Immunol Res. 2016 07; 4(7):639-41. Zah E, Lin MY, Silva-Benedict A, Jensen MC, Chen YY. PMID: 27371639; PMCID: PMC4943870.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    33. T Cells Expressing CD19/CD20 Bispecific Chimeric Antigen Receptors Prevent Antigen Escape by Malignant B Cells. Cancer Immunol Res. 2016 06; 4(6):498-508. Zah E, Lin MY, Silva-Benedict A, Jensen MC, Chen YY. PMID: 27059623; PMCID: PMC4933590.
      View in: PubMed   Mentions: 270     Fields:    Translation:HumansAnimalsCells
    34. Quantitative Analyses of Core Promoters Enable Precise Engineering of Regulated Gene Expression in Mammalian Cells. ACS Synth Biol. 2016 05 20; 5(5):395-404. Ede C, Chen X, Lin MY, Chen YY. PMID: 26883397; PMCID: PMC4874895.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    35. Efficient Gene Editing in Primary Human T Cells. Trends Immunol. 2015 Nov; 36(11):667-669. Chen YY. PMID: 26440702.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    36. Identification and selective expansion of functionally superior T cells expressing chimeric antigen receptors. J Transl Med. 2015 May 20; 13:161. Chang ZL, Silver PA, Chen YY. PMID: 25990251; PMCID: PMC4457995.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    37. Synthetic biology: advancing biological frontiers by building synthetic systems. Genome Biol. 2012 Feb 20; 13(2):240. Chen YY, Galloway KE, Smolke CD. PMID: 22348749; PMCID: PMC3334564.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    38. From DNA to targeted therapeutics: bringing synthetic biology to the clinic. Sci Transl Med. 2011 Oct 26; 3(106):106ps42. Chen YY, Smolke CD. PMID: 22030748; PMCID: PMC3285276.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    39. Design of small molecule-responsive microRNAs based on structural requirements for Drosha processing. Nucleic Acids Res. 2011 Apr; 39(7):2981-94. Beisel CL, Chen YY, Culler SJ, Hoff KG, Smolke CD. PMID: 21149259; PMCID: PMC3074164.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    40. Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems. Proc Natl Acad Sci U S A. 2010 May 11; 107(19):8531-6. Chen YY, Jensen MC, Smolke CD. PMID: 20421500; PMCID: PMC2889348.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansAnimalsCells
    With one click, see people who:

    Run Clinical Trials

    See more options in the Advanced Search tab

    Yvonne's Networks
    Concepts (119)
    Derived automatically from this person's publications.
    Explore
    _
    Co-Authors (16)
    People in Profiles who have published with this person.
    Explore
    _
    Similar People (60)
    People who share similar concepts with this person.
    Explore
    _
    Same Department
    Search Department
    _

    UCLA Profiles is managed by the UCSF Clinical and Translational Science Institute (CTSI), part of the Clinical and Translational Science Award program funded by the National Center for Advancing Translational Sciences (Grant Number UL1 TR000004) at the National Institutes of Health (NIH).
    This site is running Profiles RNS version UCSF-v3.1.0-3-g1ef1264b on PROFILES-PWEB03. We use cookies to operate our website. We also use cookies to analyze our site’s performance and improve your experience on our site. For more information about how we use cookies, please see our Website Terms of Use.

    Copyright © The Regents of the University of California