Yvonne Yu-Hsuan Chen

Photo of Yvonne Yu-Hsuan Chen
Title(s)Professor, MIMG
SchoolMedicine
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    Collapse Biography 
    Collapse education and training
    Stanford University, Stanford, CaliforniaBS06/2004Chemical Engineering
    California Institute of Technology, Pasadena, CAPhD12/2010Chemical Engineering
    Harvard Medical School, Boston, MAPostdoc06/2013Systems Biology

    Collapse Research 
    Collapse research activities and funding
    Programming multi-pronged immune response to glioblastoma with IL-13Ra2/TGF-b CAR-T cell therapy.
    NIH R01NS126849Mar 1, 2023 - Jan 31, 2028
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Armored chimeric antigen receptor T-cell therapy targets antigen-heterogeneous glioma. Cancer Res. 2026 May 20. Clubb JD, Shih RM, Gao TA, Shafer A, Vajragiri S, Lam K, Talluri S, Bouren A, Brown CE, Ruivo P, Prins RM, Wu HC, Chen YY. PMID: 42159488; PMCID: PMC13263108.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Engineering CAR T cells to secrete VEGF-neutralizing scFvs enhances antitumor activity against solid tumors. Sci Transl Med. 2026 Mar 04; 18(839):eadw9286. Gao TA, Shih RM, Clubb JD, Hung SH, Singh T, James-Allan LB, DiBernardo G, Shafer A, Bouren A, Ayala Ceja M, Ong S, Ball AB, Divakaruni AS, Memarzadeh S, Wu HC, Chen YY. PMID: 41779870.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. What do you most hope we will achieve with mammalian synthetic biology within the next decade? Cell Syst. 2025 Dec 17; 16(12):101485. Fussenegger M, Chen YY, Wong W, Borth N, Rosser S, Morsut L, Di Ventura B, Garton M, Leonard JN, Bintu L. PMID: 41412111.
      View in: PubMed   Mentions:    Fields:    
    4. Overcoming solid-tumor barriers: armored CAR-T cell therapy. Trends Cancer. 2025 Oct; 11(10):1019-1029. Kwon N, Chen YY. PMID: 40940282.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    5. IL-13Rα2/TGF-β bispecific CAR-T cells counter TGF-β-mediated immune suppression and potentiate anti-tumor responses in glioblastoma. Neuro Oncol. 2024 Oct 03; 26(10):1850-1866. Hou AJ, Shih RM, Uy BR, Shafer A, Chang ZL, Comin-Anduix B, Guemes M, Galic Z, Phyu S, Okada H, Grausam KB, Breunig JJ, Brown CE, Nathanson DA, Prins RM, Chen YY. PMID: 38982561; PMCID: PMC11449012.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    6. What tool or method do you wish existed? Cell. 2024 Aug 22; 187(17):4433-4438. Chen YY, Evavold CL, Mann M, Davenport ER, McFall-Ngai M, Bienko M, Ueda HR, Tian L, Tjahjono N, Anikeeva P, Liu JG, Deans TL, Shen X. PMID: 39178826.
      View in: PubMed   Mentions: 3     Fields:    
    7. Extracellular domains of CARs reprogramme T cell metabolism without antigen stimulation. Nat Metab. 2024 Jun; 6(6):1143-1160. Lakhani A, Chen X, Chen LC, Hong M, Khericha M, Chen Y, Chen YY, Park JO. PMID: 38658805; PMCID: PMC11845092.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    8. Self-regulating CAR-T cells modulate cytokine release syndrome in adoptive T-cell therapy. J Exp Med. 2024 Jun 03; 221(6). Lin MY, Nam E, Shih RM, Shafer A, Bouren A, Ayala Ceja M, Harris C, Khericha M, Vo KH, Kim M, Tseng CH, Chen YY. PMID: 38607370; PMCID: PMC11010356.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    9. CAR-T cell manufacturing: Major process parameters and next-generation strategies. J Exp Med. 2024 Feb 05; 221(2). Ayala Ceja M, Khericha M, Harris CM, Puig-Saus C, Chen YY. PMID: 38226974; PMCID: PMC10791545.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansCells
    10. Advances in promoting chimeric antigen receptor T cell trafficking and infiltration of solid tumors. Curr Opin Biotechnol. 2023 12; 84:103020. Hong M, Talluri S, Chen YY. PMID: 37976958.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    11. Successes and challenges in clinical gene therapy. Gene Ther. 2023 11; 30(10-11):738-746. Kohn DB, Chen YY, Spencer MJ. PMID: 37935854; PMCID: PMC10678346.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    12. Synthetic Biology in the Engineering of CAR-T and CAR-NK Cell Therapies: Facts and Hopes. Clin Cancer Res. 2023 04 14; 29(8):1390-1402. Clubb JD, Gao TA, Chen YY. PMID: 36454122; PMCID: PMC10106357.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    13. Extracellular Domains of CAR Reprogram T-Cell Metabolism Without Antigen Stimulation. bioRxiv. 2023 Apr 04. Lakhani A, Chen X, Chen LC, Khericha M, Chen YY, Park JO. PMID: 37066394; PMCID: PMC10103977.
      View in: PubMed   Mentions:
    14. CD19/CD20 Bispecific Chimeric Antigen Receptor (CAR) in Naive/Memory T Cells for the Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma. Cancer Discov. 2023 03 01; 13(3):580-597. Larson SM, Walthers CM, Ji B, Ghafouri SN, Naparstek J, Trent J, Chen JM, Roshandell M, Harris C, Khericha M, Schweppe T, Berent-Maoz B, Gosliner SB, Almaktari A, Ceja MA, Allen-Auerbach MS, Said J, Nawaly K, Mead M, de Vos S, Young PA, Oliai C, Schiller GJ, Timmerman JM, Ribas A, Chen YY. PMID: 36416874; PMCID: PMC9992104.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    15. Rational Protein Design Yields a CD20 CAR with Superior Antitumor Efficacy Compared with CD19 CAR. Cancer Immunol Res. 2023 02 03; 11(2):150-163. Chen X, Chen LC, Khericha M, Meng X, Salvestrini E, Shafer A, Iyer N, Alag AS, Ding Y, Nicolaou DM, Chen YY. PMID: 36409926; PMCID: PMC9898126.
      View in: PubMed   Mentions: 9     Fields:    
    16. The sound of silence: Transgene silencing in mammalian cell engineering. Cell Syst. 2022 12 21; 13(12):950-973. Cabrera A, Edelstein HI, Glykofrydis F, Love KS, Palacios S, Tycko J, Zhang M, Lensch S, Shields CE, Livingston M, Weiss R, Zhao H, Haynes KA, Morsut L, Chen YY, Khalil AS, Wong WW, Collins JJ, Rosser SJ, Polizzi K, Elowitz MB, Fussenegger M, Hilton IB, Leonard JN, Bintu L, Galloway KE, Deans TL. PMID: 36549273; PMCID: PMC9880859.
      View in: PubMed   Mentions: 98     Fields:    Translation:Animals
    17. Distinct population and single-neuron selectivity for executive and episodic processing in human dorsal posterior cingulate. Elife. 2022 09 28; 11. Aponik-Gremillion L, Chen YY, Bartoli E, Koslov SR, Rey HG, Weiner KS, Yoshor D, Hayden BY, Sheth SA, Foster BL. PMID: 36169132; PMCID: PMC9519147.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    18. Engineering Next-Generation CAR-T Cells: Overcoming Tumor Hypoxia and Metabolism. Annu Rev Chem Biomol Eng. 2022 06 10; 13:193-216. Gao TA, Chen YY. PMID: 35700528.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    19. T cells to fix a broken heart. Science. 2022 Jan 07; 375(6576):23-24. Gao TA, Chen YY. PMID: 34990255.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    20. Engineering Principles for Synthetic Biology Circuits in Cancer Immunotherapy. Cancer Immunol Res. 2022 01; 10(1):6-11. Shih RM, Chen YY. PMID: 34983828.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    21. Killer fatigue: Transition to NK-cell-like phenotype is a signature of CAR-T cell exhaustion. Cell. 2021 12 09; 184(25):6017-6019. Hong M, Chen YY. PMID: 34890549.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    22. Getting better mileage with logically primed CARs. Med. 2021 07 09; 2(7):785-787. Chen LC, Hou AJ, Chen YY. PMID: 35590214.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    23. Navigating CAR-T cells through the solid-tumour microenvironment. Nat Rev Drug Discov. 2021 07; 20(7):531-550. Hou AJ, Chen LC, Chen YY. PMID: 33972771.
      View in: PubMed   Mentions: 298     Fields:    Translation:HumansAnimalsCells
    24. What is the Optimal Design-Build-Test Cycle for Clinically Relevant Synthetic CAR T Cell Therapies? Cell Syst. 2020 09 23; 11(3):212-214. Chen YY, Lim W, Levings M, Blazar B, Krenciute G, Wong W, Lehner M. PMID: 32970992; PMCID: PMC7861890.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. A Fresh Approach to Targeting Aging Cells: CAR-T Cells Enhance Senolytic Specificity. Cell Stem Cell. 2020 08 06; 27(2):192-194. Li JH, Chen YY. PMID: 32763179; PMCID: PMC7717659.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    26. CAR-T design: Elements and their synergistic function. EBioMedicine. 2020 Aug; 58:102931. Jayaraman J, Mellody MP, Hou AJ, Desai RP, Fung AW, Pham AHT, Chen YY, Zhao W. PMID: 32739874; PMCID: PMC7393540.
      View in: PubMed   Mentions: 212     Fields:    Translation:HumansCells
    27. Engineering CAR-T Cells for Next-Generation Cancer Therapy. Cancer Cell. 2020 10 12; 38(4):473-488. Hong M, Clubb JD, Chen YY. PMID: 32735779.
      View in: PubMed   Mentions: 358     Fields:    Translation:HumansAnimalsCells
    28. Systematically optimized BCMA/CS1 bispecific CAR-T cells robustly control heterogeneous multiple myeloma. Nat Commun. 2020 05 08; 11(1):2283. Zah E, Nam E, Bhuvan V, Tran U, Ji BY, Gosliner SB, Wang X, Brown CE, Chen YY. PMID: 32385241; PMCID: PMC7210316.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansCells
    29. Engineering primary T cells with chimeric antigen receptors for rewired responses to soluble ligands. Nat Protoc. 2020 04; 15(4):1507-1524. Chang ZL, Hou AJ, Chen YY. PMID: 32103205; PMCID: PMC7430204.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    30. Editorial overview: Pharmaceutical biotechnology: new frontiers in protein, gene, and cell therapies. Curr Opin Biotechnol. 2019 12; 60:iii-v. Chen YY, Van Deventer JA. PMID: 31690473.
      View in: PubMed   Mentions:    Fields:    
    31. Cell fishing with DNA aptamers. Nat Biomed Eng. 2019 10; 3(10):757-758. Chen YY. PMID: 31591522.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    32. Outsmarting and outmuscling cancer cells with synthetic and systems immunology. Curr Opin Biotechnol. 2019 12; 60:111-118. Chen LC, Chen YY. PMID: 30822698.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    33. TGF-β-responsive CAR-T cells promote anti-tumor immune function. Bioeng Transl Med. 2018 May; 3(2):75-86. Hou AJ, Chang ZL, Lorenzini MH, Zah E, Chen YY. PMID: 30065964; PMCID: PMC6063867.
      View in: PubMed   Mentions: 59  
    34. Synthetic biology advances and applications in the biotechnology industry: a perspective. J Ind Microbiol Biotechnol. 2018 Jul; 45(7):449-461. Katz L, Chen YY, Gonzalez R, Peterson TC, Zhao H, Baltz RH. PMID: 29915997.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    35. Increasing T Cell Versatility with SUPRA CARs. Cell. 2018 05 31; 173(6):1316-1317. Chen YY. PMID: 29856949.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    36. Regulation of T cell proliferation with drug-responsive microRNA switches. Nucleic Acids Res. 2018 02 16; 46(3):1541-1552. Wong RS, Chen YY, Smolke CD. PMID: 29244152; PMCID: PMC5815133.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    37. Rewiring T-cell responses to soluble factors with chimeric antigen receptors. Nat Chem Biol. 2018 03; 14(3):317-324. Chang ZL, Lorenzini MH, Chen X, Tran U, Bangayan NJ, Chen YY. PMID: 29377003; PMCID: PMC6035732.
      View in: PubMed   Mentions: 149     Fields:    Translation:HumansCells
    38. Mammalian synthetic biology in the age of genome editing and personalized medicine. Curr Opin Chem Biol. 2017 Oct; 40:57-64. Ho P, Chen YY. PMID: 28628856; PMCID: PMC5696019.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    39. Modularly Constructed Synthetic Granzyme B Molecule Enables Interrogation of Intracellular Proteases for Targeted Cytotoxicity. ACS Synth Biol. 2017 08 18; 6(8):1484-1495. Ho P, Ede C, Chen YY. PMID: 28510446; PMCID: PMC5683712.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    40. CARs: Synthetic Immunoreceptors for Cancer Therapy and Beyond. Trends Mol Med. 2017 05; 23(5):430-450. Chang ZL, Chen YY. PMID: 28416139; PMCID: PMC5423782.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    41. ADDENDUM: T Cells Expressing CD19/CD20 Bispecific Chimeric Antigen Receptors Prevent Antigen Escape by Malignant B Cells. Cancer Immunol Res. 2016 07; 4(7):639-41. Zah E, Lin MY, Silva-Benedict A, Jensen MC, Chen YY. PMID: 27371639; PMCID: PMC4943870.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    42. T Cells Expressing CD19/CD20 Bispecific Chimeric Antigen Receptors Prevent Antigen Escape by Malignant B Cells. Cancer Immunol Res. 2016 06; 4(6):498-508. Zah E, Lin MY, Silva-Benedict A, Jensen MC, Chen YY. PMID: 27059623; PMCID: PMC4933590.
      View in: PubMed   Mentions: 336     Fields:    Translation:HumansAnimalsCells
    43. Quantitative Analyses of Core Promoters Enable Precise Engineering of Regulated Gene Expression in Mammalian Cells. ACS Synth Biol. 2016 05 20; 5(5):395-404. Ede C, Chen X, Lin MY, Chen YY. PMID: 26883397; PMCID: PMC4874895.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    44. Efficient Gene Editing in Primary Human T Cells. Trends Immunol. 2015 Nov; 36(11):667-669. Chen YY. PMID: 26440702.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    45. Identification and selective expansion of functionally superior T cells expressing chimeric antigen receptors. J Transl Med. 2015 May 20; 13:161. Chang ZL, Silver PA, Chen YY. PMID: 25990251; PMCID: PMC4457995.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    46. Synthetic biology: advancing biological frontiers by building synthetic systems. Genome Biol. 2012 Feb 20; 13(2):240. Chen YY, Galloway KE, Smolke CD. PMID: 22348749; PMCID: PMC3334564.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    47. From DNA to targeted therapeutics: bringing synthetic biology to the clinic. Sci Transl Med. 2011 Oct 26; 3(106):106ps42. Chen YY, Smolke CD. PMID: 22030748; PMCID: PMC3285276.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    48. Design of small molecule-responsive microRNAs based on structural requirements for Drosha processing. Nucleic Acids Res. 2011 Apr; 39(7):2981-94. Beisel CL, Chen YY, Culler SJ, Hoff KG, Smolke CD. PMID: 21149259; PMCID: PMC3074164.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    49. Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems. Proc Natl Acad Sci U S A. 2010 May 11; 107(19):8531-6. Chen YY, Jensen MC, Smolke CD. PMID: 20421500; PMCID: PMC2889348.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansAnimalsCells
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