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Yvonne Yu-Hsuan Chen

Title(s)Associate Professor, MIMG
SchoolMedicine
Address609 Charles E. Young Drive, Ea 1602A
Los Angeles CA 90024
Phone310-825-2816
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    Collapse Research 
    Collapse Research Activities and Funding
    Engineering of computational receptors and gene circuits for T-cell immunotherapy
    NIH DP5OD012133Sep 25, 2012 - Aug 31, 2017
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A Fresh Approach to Targeting Aging Cells: CAR-T Cells Enhance Senolytic Specificity. Cell Stem Cell. 2020 Aug 06; 27(2):192-194. Li JH, Chen YY. PMID: 32763179.
      View in: PubMed   Mentions:    Fields:    
    2. Engineering CAR-T Cells for Next-Generation Cancer Therapy. Cancer Cell. 2020 Jul 28. Hong M, Clubb JD, Chen YY. PMID: 32735779.
      View in: PubMed   Mentions: 1     Fields:    
    3. Systematically optimized BCMA/CS1 bispecific CAR-T cells robustly control heterogeneous multiple myeloma. Nat Commun. 2020 05 08; 11(1):2283. Zah E, Nam E, Bhuvan V, Tran U, Ji BY, Gosliner SB, Wang X, Brown CE, Chen YY. PMID: 32385241.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    4. Engineering primary T cells with chimeric antigen receptors for rewired responses to soluble ligands. Nat Protoc. 2020 04; 15(4):1507-1524. Chang ZL, Hou AJ, Chen YY. PMID: 32103205.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Editorial overview: Pharmaceutical biotechnology: new frontiers in protein, gene, and cell therapies. Curr Opin Biotechnol. 2019 12; 60:iii-v. Chen YY, Van Deventer JA. PMID: 31690473.
      View in: PubMed   Mentions:    Fields:    
    6. Cell fishing with DNA aptamers. Nat Biomed Eng. 2019 10; 3(10):757-758. Chen YY. PMID: 31591522.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    7. Outsmarting and outmuscling cancer cells with synthetic and systems immunology. Curr Opin Biotechnol. 2019 12; 60:111-118. Chen LC, Chen YY. PMID: 30822698.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    8. TGF-ß-responsive CAR-T cells promote anti-tumor immune function. Bioeng Transl Med. 2018 May; 3(2):75-86. Hou AJ, Chang ZL, Lorenzini MH, Zah E, Chen YY. PMID: 30065964.
      View in: PubMed   Mentions:
    9. Increasing T Cell Versatility with SUPRA CARs. Cell. 2018 05 31; 173(6):1316-1317. Chen YY. PMID: 29856949.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    10. Rewiring T-cell responses to soluble factors with chimeric antigen receptors. Nat Chem Biol. 2018 03; 14(3):317-324. Chang ZL, Lorenzini MH, Chen X, Tran U, Bangayan NJ, Chen YY. PMID: 29377003.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    11. Mammalian synthetic biology in the age of genome editing and personalized medicine. Curr Opin Chem Biol. 2017 Oct; 40:57-64. Ho P, Chen YY. PMID: 28628856.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    12. Modularly Constructed Synthetic Granzyme B Molecule Enables Interrogation of Intracellular Proteases for Targeted Cytotoxicity. ACS Synth Biol. 2017 08 18; 6(8):1484-1495. Ho P, Ede C, Chen YY. PMID: 28510446.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    13. CARs: Synthetic Immunoreceptors for Cancer Therapy and Beyond. Trends Mol Med. 2017 05; 23(5):430-450. Chang ZL, Chen YY. PMID: 28416139.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    14. T Cells Expressing CD19/CD20 Bispecific Chimeric Antigen Receptors Prevent Antigen Escape by Malignant B Cells. Cancer Immunol Res. 2016 06; 4(6):498-508. Zah E, Lin MY, Silva-Benedict A, Jensen MC, Chen YY. PMID: 27059623.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    15. Quantitative Analyses of Core Promoters Enable Precise Engineering of Regulated Gene Expression in Mammalian Cells. ACS Synth Biol. 2016 05 20; 5(5):395-404. Ede C, Chen X, Lin MY, Chen YY. PMID: 26883397.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    16. Efficient Gene Editing in Primary Human T Cells. Trends Immunol. 2015 Nov; 36(11):667-669. Chen YY. PMID: 26440702.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    17. Identification and selective expansion of functionally superior T cells expressing chimeric antigen receptors. J Transl Med. 2015 May 20; 13:161. Chang ZL, Silver PA, Chen YY. PMID: 25990251.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
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