Yvonne Yu-Hsuan Chen

Title(s)Associate Professor, MIMG
SchoolMedicine
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    Collapse Research 
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    Engineering of computational receptors and gene circuits for T-cell immunotherapy
    NIH DP5OD012133Sep 25, 2012 - Aug 31, 2018
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Engineering Next-Generation CAR-T Cells: Overcoming Tumor Hypoxia and Metabolism. Annu Rev Chem Biomol Eng. 2022 06 10; 13:193-216. Gao TA, Chen YY. PMID: 35700528.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. T cells to fix a broken heart. Science. 2022 Jan 07; 375(6576):23-24. Gao TA, Chen YY. PMID: 34990255.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    3. Engineering Principles for Synthetic Biology Circuits in Cancer Immunotherapy. Cancer Immunol Res. 2022 01; 10(1):6-11. Shih RM, Chen YY. PMID: 34983828.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Killer fatigue: Transition to NK-cell-like phenotype is a signature of CAR-T cell exhaustion. Cell. 2021 12 09; 184(25):6017-6019. Hong M, Chen YY. PMID: 34890549.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Getting better mileage with logically primed CARs. Med (N Y). 2021 07 09; 2(7):785-787. Chen LC, Hou AJ, Chen YY. PMID: 35590214.
      View in: PubMed   Mentions: Translation:HumansCells
    6. Navigating CAR-T cells through the solid-tumour microenvironment. Nat Rev Drug Discov. 2021 07; 20(7):531-550. Hou AJ, Chen LC, Chen YY. PMID: 33972771.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    7. What is the Optimal Design-Build-Test Cycle for Clinically Relevant Synthetic CAR T Cell Therapies? Cell Syst. 2020 09 23; 11(3):212-214. Chen YY, Lim W, Levings M, Blazar B, Krenciute G, Wong W, Lehner M. PMID: 32970992; PMCID: PMC7861890.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. A Fresh Approach to Targeting Aging Cells: CAR-T Cells Enhance Senolytic Specificity. Cell Stem Cell. 2020 08 06; 27(2):192-194. Li JH, Chen YY. PMID: 32763179; PMCID: PMC7717659.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    9. CAR-T design: Elements and their synergistic function. EBioMedicine. 2020 Aug; 58:102931. Jayaraman J, Mellody MP, Hou AJ, Desai RP, Fung AW, Pham AHT, Chen YY, Zhao W. PMID: 32739874; PMCID: PMC7393540.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    10. Engineering CAR-T Cells for Next-Generation Cancer Therapy. Cancer Cell. 2020 10 12; 38(4):473-488. Hong M, Clubb JD, Chen YY. PMID: 32735779.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    11. Systematically optimized BCMA/CS1 bispecific CAR-T cells robustly control heterogeneous multiple myeloma. Nat Commun. 2020 05 08; 11(1):2283. Zah E, Nam E, Bhuvan V, Tran U, Ji BY, Gosliner SB, Wang X, Brown CE, Chen YY. PMID: 32385241; PMCID: PMC7210316.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    12. Engineering primary T cells with chimeric antigen receptors for rewired responses to soluble ligands. Nat Protoc. 2020 04; 15(4):1507-1524. Chang ZL, Hou AJ, Chen YY. PMID: 32103205; PMCID: PMC7430204.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    13. Editorial overview: Pharmaceutical biotechnology: new frontiers in protein, gene, and cell therapies. Curr Opin Biotechnol. 2019 12; 60:iii-v. Chen YY, Van Deventer JA. PMID: 31690473.
      View in: PubMed   Mentions:    Fields:    
    14. Cell fishing with DNA aptamers. Nat Biomed Eng. 2019 10; 3(10):757-758. Chen YY. PMID: 31591522.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    15. Outsmarting and outmuscling cancer cells with synthetic and systems immunology. Curr Opin Biotechnol. 2019 12; 60:111-118. Chen LC, Chen YY. PMID: 30822698.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    16. TGF-β-responsive CAR-T cells promote anti-tumor immune function. Bioeng Transl Med. 2018 May; 3(2):75-86. Hou AJ, Chang ZL, Lorenzini MH, Zah E, Chen YY. PMID: 30065964; PMCID: PMC6063867.
      View in: PubMed   Mentions: 24  
    17. Synthetic biology advances and applications in the biotechnology industry: a perspective. J Ind Microbiol Biotechnol. 2018 Jul; 45(7):449-461. Katz L, Chen YY, Gonzalez R, Peterson TC, Zhao H, Baltz RH. PMID: 29915997.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    18. Increasing T Cell Versatility with SUPRA CARs. Cell. 2018 05 31; 173(6):1316-1317. Chen YY. PMID: 29856949.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    19. Rewiring T-cell responses to soluble factors with chimeric antigen receptors. Nat Chem Biol. 2018 03; 14(3):317-324. Chang ZL, Lorenzini MH, Chen X, Tran U, Bangayan NJ, Chen YY. PMID: 29377003; PMCID: PMC6035732.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansCells
    20. Mammalian synthetic biology in the age of genome editing and personalized medicine. Curr Opin Chem Biol. 2017 Oct; 40:57-64. Ho P, Chen YY. PMID: 28628856; PMCID: PMC5696019.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    21. Modularly Constructed Synthetic Granzyme B Molecule Enables Interrogation of Intracellular Proteases for Targeted Cytotoxicity. ACS Synth Biol. 2017 08 18; 6(8):1484-1495. Ho P, Ede C, Chen YY. PMID: 28510446; PMCID: PMC5683712.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    22. CARs: Synthetic Immunoreceptors for Cancer Therapy and Beyond. Trends Mol Med. 2017 05; 23(5):430-450. Chang ZL, Chen YY. PMID: 28416139; PMCID: PMC5423782.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    23. ADDENDUM: T Cells Expressing CD19/CD20 Bispecific Chimeric Antigen Receptors Prevent Antigen Escape by Malignant B Cells. Cancer Immunol Res. 2016 07; 4(7):639-41. Zah E, Lin MY, Silva-Benedict A, Jensen MC, Chen YY. PMID: 27371639; PMCID: PMC4943870.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    24. T Cells Expressing CD19/CD20 Bispecific Chimeric Antigen Receptors Prevent Antigen Escape by Malignant B Cells. Cancer Immunol Res. 2016 06; 4(6):498-508. Zah E, Lin MY, Silva-Benedict A, Jensen MC, Chen YY. PMID: 27059623; PMCID: PMC4933590.
      View in: PubMed   Mentions: 213     Fields:    Translation:HumansAnimalsCells
    25. Quantitative Analyses of Core Promoters Enable Precise Engineering of Regulated Gene Expression in Mammalian Cells. ACS Synth Biol. 2016 05 20; 5(5):395-404. Ede C, Chen X, Lin MY, Chen YY. PMID: 26883397; PMCID: PMC4874895.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    26. Efficient Gene Editing in Primary Human T Cells. Trends Immunol. 2015 Nov; 36(11):667-669. Chen YY. PMID: 26440702.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    27. Identification and selective expansion of functionally superior T cells expressing chimeric antigen receptors. J Transl Med. 2015 May 20; 13:161. Chang ZL, Silver PA, Chen YY. PMID: 25990251; PMCID: PMC4457995.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    28. Synthetic biology: advancing biological frontiers by building synthetic systems. Genome Biol. 2012 Feb 20; 13(2):240. Chen YY, Galloway KE, Smolke CD. PMID: 22348749; PMCID: PMC3334564.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    29. From DNA to targeted therapeutics: bringing synthetic biology to the clinic. Sci Transl Med. 2011 Oct 26; 3(106):106ps42. Chen YY, Smolke CD. PMID: 22030748; PMCID: PMC3285276.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    30. Design of small molecule-responsive microRNAs based on structural requirements for Drosha processing. Nucleic Acids Res. 2011 Apr; 39(7):2981-94. Beisel CL, Chen YY, Culler SJ, Hoff KG, Smolke CD. PMID: 21149259; PMCID: PMC3074164.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    31. Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems. Proc Natl Acad Sci U S A. 2010 May 11; 107(19):8531-6. Chen YY, Jensen MC, Smolke CD. PMID: 20421500; PMCID: PMC2889348.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
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