Joshua John Breunig

Title(s)Associate Adjunct Professor, Medicine
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    GESTALT Barcoding and Single-cell Transcriptomics of Tumor Cell Evolution in Personalized Tumor Models
    NIH R33CA236687Apr 11, 2019 - Mar 31, 2022
    Role: Principal Investigator
    Direct Differentiations of iPSCs: an Autologous and Scalable Source of Striatal Medium Spiny Neurons for Cellular Transplantation Therapy
    NIH R03NS101529Jun 1, 2017 - Sep 30, 2020
    Role: Principal Investigator
    A Genetic Toolbox for the Identification and Interrogation of Tumor Cells of Origin, Propagation, and Recurrence From Patient-derived Oncogenic Drivers
    NIH R33CA202900May 1, 2016 - Apr 30, 2019
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. In vivo discovery of RNA proximal proteins via proximity-dependent biotinylation. RNA Biol. 2021 May 19; 1-15. Lin X, Fonseca MAS, Breunig JJ, Corona RI, Lawrenson K. PMID: 34006179.
      View in: PubMed   Mentions:    Fields:    
    2. RELA Fusion-Positive Ependymoma in a Child with Down Syndrome: A Case Report. Pediatr Neurosurg. 2021; 56(2):146-151. Chan JL, Kashanian A, Bannykh SI, Majlessipour F, Breunig JJ, Danielpour M. PMID: 33690230.
      View in: PubMed   Mentions:    Fields:    
    3. A Transcriptional Regulatory Loop of Master Regulator Transcription Factors, PPARG, and Fatty Acid Synthesis Promotes Esophageal Adenocarcinoma. Cancer Res. 2021 03 01; 81(5):1216-1229. Ma S, Zhou B, Yang Q, Pan Y, Yang W, Freedland SJ, Ding LW, Freeman MR, Breunig JJ, Bhowmick NA, Pan J, Koeffler HP, Lin DC. PMID: 33402390.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. Preparation, Assembly, and Transduction of Transgenic Elements Using Mosaic Analysis with Dual Recombinases (MADR). STAR Protoc. 2020 Dec 18; 1(3):100199. Rincon Fernandez Pacheco D, Sabet S, Breunig JJ. PMID: 33377093.
      View in: PubMed   Mentions:
    5. De Novo Generation of Murine and Human MADR Recipient Cell Lines for Locus-Specific, Stable Integration of Transgenic Elements. STAR Protoc. 2020 Dec 18; 1(3):100184. Ayala-Sarmiento AE, Kobritz N, Breunig JJ. PMID: 33377078.
      View in: PubMed   Mentions:
    6. Rapid Generation of Somatic Mouse Mosaics with Locus-Specific, Stably Integrated Transgenic Elements. Cell. 2019 09 19; 179(1):251-267.e24. Kim GB, Rincon Fernandez Pacheco D, Saxon D, Yang A, Sabet S, Dutra-Clarke M, Levy R, Watkins A, Park H, Abbasi Akhtar A, Linesch PW, Kobritz N, Chandra SS, Grausam K, Ayala-Sarmiento A, Molina J, Sedivakova K, Hoang K, Tsyporin J, Gareau DS, Filbin MG, Bannykh S, Santiskulvong C, Wang Y, Tang J, Suva ML, Chen B, Danielpour M, Breunig JJ. PMID: 31539496.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    7. Glioma cell proliferation is enhanced in the presence of tumor-derived cilia vesicles. Cilia. 2018; 7:6. Hoang-Minh LB, Dutra-Clarke M, Breunig JJ, Sarkisian MR. PMID: 30410731.
      View in: PubMed   Mentions: 9  
    8. Inflammation-induced Gro1 triggers senescence in neuronal progenitors: effects of estradiol. J Neuroinflammation. 2018 Sep 11; 15(1):260. Zonis S, Breunig JJ, Mamelak A, Wawrowsky K, Bresee C, Ginzburg N, Chesnokova V. PMID: 30201019.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    9. In utero electroporation-based translating ribosome affinity purification identifies age-dependent mRNA expression in cortical pyramidal neurons. Neurosci Res. 2019 Jun; 143:44-52. Huang T, Nguyen LH, Lin TV, Gong X, Zhang L, Kim GB, Sarkisian MR, Breunig JJ, Bordey A. PMID: 29857015.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    10. Inducible Expression of GDNF in Transplanted iPSC-Derived Neural Progenitor Cells. Stem Cell Reports. 2018 06 05; 10(6):1696-1704. Akhtar AA, Gowing G, Kobritz N, Savinoff SE, Garcia L, Saxon D, Cho N, Kim G, Tom CM, Park H, Lawless G, Shelley BC, Mattis VB, Breunig JJ, Svendsen CN. PMID: 29706501.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    11. Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities. Cancer Metab. 2018; 6:4. Garrett M, Sperry J, Braas D, Yan W, Le TM, Mottahedeh J, Ludwig K, Eskin A, Qin Y, Levy R, Breunig JJ, Pajonk F, Graeber TG, Radu CG, Christofk H, Prins RM, Lai A, Liau LM, Coppola G, Kornblum HI. PMID: 29692895.
      View in: PubMed   Mentions: 19  
    12. Tetracycline-Inducible and Reversible Stable Gene Expression in Human iPSC-Derived Neural Progenitors and in the Postnatal Mouse Brain. Curr Protoc Stem Cell Biol. 2017 May 16; 41:5A.9.1-5A.9.12. Akhtar AA, Breunig JJ. PMID: 28510333.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    13. Lethal Giant Lineage Tracing: Mutating Locally, Acting Globally. Neuron. 2017 May 03; 94(3):417-420. Akhtar AA, Park H, Breunig JJ. PMID: 28472645.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    14. Organoid and Organ-On-A-Chip Systems: New Paradigms for Modeling Neurological and Gastrointestinal Disease. Curr Stem Cell Rep. 2017 Jun; 3(2):98-111. Akhtar AA, Sances S, Barrett R, Breunig JJ. PMID: 28983454.
      View in: PubMed   Mentions: 6  
    15. BCL6 promotes glioma and serves as a therapeutic target. Proc Natl Acad Sci U S A. 2017 04 11; 114(15):3981-3986. Xu L, Chen Y, Dutra-Clarke M, Mayakonda A, Hazawa M, Savinoff SE, Doan N, Said JW, Yong WH, Watkins A, Yang H, Ding LW, Jiang YY, Tyner JW, Ching J, Kovalik JP, Madan V, Chan SL, Müschen M, Breunig JJ, Lin DC, Koeffler HP. PMID: 28356518.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    16. Ets Factors Regulate Neural Stem Cell Depletion and Gliogenesis in Ras Pathway Glioma. Cell Rep. 2016 12 20; 17(12):3407. Breunig JJ, Levy R, Antonuk CD, Molina J, Dutra-Clarke M, Park H, Akhtar AA, Kim GB, Town T, Hu X, Bannykh SI, Verhaak RGW, Danielpour M. PMID: 28009307.
      View in: PubMed   Mentions: 2     Fields:    
    17. In Vivo CRISPR/Cas9 Gene Editing Corrects Retinal Dystrophy in the S334ter-3 Rat Model of Autosomal Dominant Retinitis Pigmentosa. Mol Ther. 2016 Mar; 24(3):556-63. Bakondi B, Lv W, Lu B, Jones MK, Tsai Y, Kim KJ, Levy R, Akhtar AA, Breunig JJ, Svendsen CN, Wang S. PMID: 26666451.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    18. Ets Factors Regulate Neural Stem Cell Depletion and Gliogenesis in Ras Pathway Glioma. Cell Rep. 2015 Jul 14; 12(2):258-71. Breunig JJ, Levy R, Antonuk CD, Molina J, Dutra-Clarke M, Park H, Akhtar AA, Kim GB, Hu X, Bannykh SI, Verhaak RG, Danielpour M. PMID: 26146073.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    19. Lost highway(s): barriers to postnatal cortical neurogenesis and implications for brain repair. Front Cell Neurosci. 2015; 9:216. Akhtar AA, Breunig JJ. PMID: 26136658.
      View in: PubMed   Mentions: 2  
    20. Mutations within the pathogenic region of herpes simplex virus 1 gK signal sequences alter cell surface expression and neurovirulence. J Virol. 2015 Mar; 89(5):2530-42. Matundan HH, Mott KR, Akhtar AA, Breunig JJ, Ghiasi H. PMID: 25505072.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    21. T-cell TGF-β signaling abrogation restricts medulloblastoma progression. Proc Natl Acad Sci U S A. 2014 Aug 19; 111(33):E3458-66. Gate D, Danielpour M, Rodriguez J, Kim GB, Levy R, Bannykh S, Breunig JJ, Kaech SM, Flavell RA, Town T. PMID: 25082897.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    22. Neonatal pial surface electroporation. J Vis Exp. 2014 May 07; (87). Levy R, Molina J, Danielpour M, Breunig JJ. PMID: 24836046.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    23. Brain injury, neuroinflammation and Alzheimer's disease. Front Aging Neurosci. 2013; 5:26. Breunig JJ, Guillot-Sestier MV, Town T. PMID: 23874297.
      View in: PubMed   Mentions: 39  
    24. A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric aβ, and frank neuronal loss. J Neurosci. 2013 Apr 10; 33(15):6245-56. Cohen RM, Rezai-Zadeh K, Weitz TM, Rentsendorj A, Gate D, Spivak I, Bholat Y, Vasilevko V, Glabe CG, Breunig JJ, Rakic P, Davtyan H, Agadjanyan MG, Kepe V, Barrio JR, Bannykh S, Szekely CA, Pechnick RN, Town T. PMID: 23575824.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansAnimals
    25. Arborization of dendrites by developing neocortical neurons is dependent on primary cilia and type 3 adenylyl cyclase. J Neurosci. 2013 Feb 06; 33(6):2626-38. Guadiana SM, Semple-Rowland S, Daroszewski D, Madorsky I, Breunig JJ, Mykytyn K, Sarkisian MR. PMID: 23392690.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    26. Rapid genetic targeting of pial surface neural progenitors and immature neurons by neonatal electroporation. Neural Dev. 2012 Jul 10; 7:26. Breunig JJ, Gate D, Levy R, Rodriguez J, Kim GB, Danielpour M, Svendsen CN, Town T. PMID: 22776033.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    27. Basic biology and mechanisms of neural ciliogenesis and the B9 family. Mol Neurobiol. 2012 Jun; 45(3):564-70. Gate D, Danielpour M, Levy R, Breunig JJ, Town T. PMID: 22644387.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    28. Development and distribution of neuronal cilia in mouse neocortex. J Comp Neurol. 2012 Mar 01; 520(4):848-73. Arellano JI, Guadiana SM, Breunig JJ, Rakic P, Sarkisian MR. PMID: 22020803.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    29. FGF signaling expands embryonic cortical surface area by regulating Notch-dependent neurogenesis. J Neurosci. 2011 Oct 26; 31(43):15604-17. Rash BG, Lim HD, Breunig JJ, Vaccarino FM. PMID: 22031906.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    30. Failed cytokinesis of neural progenitors in citron kinase-deficient rats leads to multiciliated neurons. Cereb Cortex. 2011 Feb; 21(2):338-44. Anastas SB, Mueller D, Semple-Rowland SL, Breunig JJ, Sarkisian MR. PMID: 20525772.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    31. Cilia in the brain: going with the flow. Nat Neurosci. 2010 Jun; 13(6):654-5. Breunig JJ, Arellano JI, Rakic P. PMID: 20498683.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    32. Decision by division: making cortical maps. Trends Neurosci. 2009 May; 32(5):291-301. Rakic P, Ayoub AE, Breunig JJ, Dominguez MH. PMID: 19380167.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimalsCells
    33. Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling. Proc Natl Acad Sci U S A. 2008 Sep 02; 105(35):13127-32. Breunig JJ, Sarkisian MR, Arellano JI, Morozov YM, Ayoub AE, Sojitra S, Wang B, Flavell RA, Rakic P, Town T. PMID: 18728187.
      View in: PubMed   Mentions: 132     Fields:    Translation:AnimalsCells
    34. The stumpy gene is required for mammalian ciliogenesis. Proc Natl Acad Sci U S A. 2008 Feb 26; 105(8):2853-8. Town T, Breunig JJ, Sarkisian MR, Spilianakis C, Ayoub AE, Liu X, Ferrandino AF, Gallagher AR, Li MO, Rakic P, Flavell RA. PMID: 18287022.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    35. Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors. Nat Neurosci. 2007 Jul; 10(7):819-27. Rasin MR, Gazula VR, Breunig JJ, Kwan KY, Johnson MB, Liu-Chen S, Li HS, Jan LY, Jan YN, Rakic P, Sestan N. PMID: 17589506.
      View in: PubMed   Mentions: 150     Fields:    Translation:HumansAnimalsCells
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