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Breunig, Joshua John

Title(s)Associate Adjunct Professor, Medicine
SchoolMed - Physical Med And Rehab
Phone(310) 248-8569
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    GESTALT Barcoding and Single-cell Transcriptomics of Tumor Cell Evolution in Personalized Tumor Models
    NIH/NCI R33CA236687Apr 11, 2019 - Mar 31, 2022
    Role: Principal Investigator
    A Genetic Toolbox for the Identification and Interrogation of Tumor Cells of Origin, Propagation, and Recurrence From Patient-derived Oncogenic Drivers
    NIH/NCI R33CA202900May 1, 2016 - Apr 30, 2019
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kim GB, Rincon Fernandez Pacheco D, Saxon D, Yang A, Sabet S, Dutra-Clarke M, Levy R, Watkins A, Park H, Abbasi Akhtar A, Linesch PW, Kobritz N, Chandra SS, Grausam K, Ayala-Sarmiento A, Molina J, Sedivakova K, Hoang K, Tsyporin J, Gareau DS, Filbin MG, Bannykh S, Santiskulvong C, Wang Y, Tang J, Suva ML, Chen B, Danielpour M, Breunig JJ. Rapid Generation of Somatic Mouse Mosaics with Locus-Specific, Stably Integrated Transgenic Elements. Cell. 2019 Sep 19; 179(1):251-267.e24. PMID: 31539496.
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    2. Hoang-Minh LB, Dutra-Clarke M, Breunig JJ, Sarkisian MR. Glioma cell proliferation is enhanced in the presence of tumor-derived cilia vesicles. Cilia. 2018; 7:6. PMID: 30410731.
      View in: PubMed
    3. Zonis S, Breunig JJ, Mamelak A, Wawrowsky K, Bresee C, Ginzburg N, Chesnokova V. Inflammation-induced Gro1 triggers senescence in neuronal progenitors: effects of estradiol. J Neuroinflammation. 2018 Sep 11; 15(1):260. PMID: 30201019.
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    4. Huang T, Nguyen LH, Lin TV, Gong X, Zhang L, Kim GB, Sarkisian MR, Breunig JJ, Bordey A. In utero electroporation-based translating ribosome affinity purification identifies age-dependent mRNA expression in cortical pyramidal neurons. Neurosci Res. 2019 Jun; 143:44-52. PMID: 29857015.
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    5. Akhtar AA, Gowing G, Kobritz N, Savinoff SE, Garcia L, Saxon D, Cho N, Kim G, Tom CM, Park H, Lawless G, Shelley BC, Mattis VB, Breunig JJ, Svendsen CN. Inducible Expression of GDNF in Transplanted iPSC-Derived Neural Progenitor Cells. Stem Cell Reports. 2018 06 05; 10(6):1696-1704. PMID: 29706501.
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    6. Garrett M, Sperry J, Braas D, Yan W, Le TM, Mottahedeh J, Ludwig K, Eskin A, Qin Y, Levy R, Breunig JJ, Pajonk F, Graeber TG, Radu CG, Christofk H, Prins RM, Lai A, Liau LM, Coppola G, Kornblum HI. Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities. Cancer Metab. 2018; 6:4. PMID: 29692895.
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    7. Akhtar AA, Breunig JJ. Tetracycline-Inducible and Reversible Stable Gene Expression in Human iPSC-Derived Neural Progenitors and in the Postnatal Mouse Brain. Curr Protoc Stem Cell Biol. 2017 May 16; 41:5A.9.1-5A.9.12. PMID: 28510333.
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    8. Akhtar AA, Park H, Breunig JJ. Lethal Giant Lineage Tracing: Mutating Locally, Acting Globally. Neuron. 2017 May 03; 94(3):417-420. PMID: 28472645.
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    9. Akhtar AA, Sances S, Barrett R, Breunig JJ. Organoid and Organ-On-A-Chip Systems: New Paradigms for Modeling Neurological and Gastrointestinal Disease. Curr Stem Cell Rep. 2017 Jun; 3(2):98-111. PMID: 28983454.
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    10. Xu L, Chen Y, Dutra-Clarke M, Mayakonda A, Hazawa M, Savinoff SE, Doan N, Said JW, Yong WH, Watkins A, Yang H, Ding LW, Jiang YY, Tyner JW, Ching J, Kovalik JP, Madan V, Chan SL, Müschen M, Breunig JJ, Lin DC, Koeffler HP. BCL6 promotes glioma and serves as a therapeutic target. Proc Natl Acad Sci U S A. 2017 04 11; 114(15):3981-3986. PMID: 28356518.
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    11. Breunig JJ, Levy R, Antonuk CD, Molina J, Dutra-Clarke M, Park H, Akhtar AA, Kim GB, Town T, Hu X, Bannykh SI, Verhaak RGW, Danielpour M. Ets Factors Regulate Neural Stem Cell Depletion and Gliogenesis in Ras Pathway Glioma. Cell Rep. 2016 12 20; 17(12):3407. PMID: 28009307.
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    12. Bakondi B, Lv W, Lu B, Jones MK, Tsai Y, Kim KJ, Levy R, Akhtar AA, Breunig JJ, Svendsen CN, Wang S. In Vivo CRISPR/Cas9 Gene Editing Corrects Retinal Dystrophy in the S334ter-3 Rat Model of Autosomal Dominant Retinitis Pigmentosa. Mol Ther. 2016 Mar; 24(3):556-63. PMID: 26666451.
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    13. Breunig JJ, Levy R, Antonuk CD, Molina J, Dutra-Clarke M, Park H, Akhtar AA, Kim GB, Hu X, Bannykh SI, Verhaak RG, Danielpour M. Ets Factors Regulate Neural Stem Cell Depletion and Gliogenesis in Ras Pathway Glioma. Cell Rep. 2015 Jul 14; 12(2):258-71. PMID: 26146073.
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    14. Akhtar AA, Breunig JJ. Lost highway(s): barriers to postnatal cortical neurogenesis and implications for brain repair. Front Cell Neurosci. 2015; 9:216. PMID: 26136658.
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    15. Matundan HH, Mott KR, Akhtar AA, Breunig JJ, Ghiasi H. Mutations within the pathogenic region of herpes simplex virus 1 gK signal sequences alter cell surface expression and neurovirulence. J Virol. 2015 Mar; 89(5):2530-42. PMID: 25505072.
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    16. Gate D, Danielpour M, Rodriguez J, Kim GB, Levy R, Bannykh S, Breunig JJ, Kaech SM, Flavell RA, Town T. T-cell TGF-ß signaling abrogation restricts medulloblastoma progression. Proc Natl Acad Sci U S A. 2014 Aug 19; 111(33):E3458-66. PMID: 25082897.
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    17. Levy R, Molina J, Danielpour M, Breunig JJ. Neonatal pial surface electroporation. J Vis Exp. 2014 May 07; (87). PMID: 24836046.
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    18. Breunig JJ, Guillot-Sestier MV, Town T. Brain injury, neuroinflammation and Alzheimer's disease. Front Aging Neurosci. 2013; 5:26. PMID: 23874297.
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    19. Cohen RM, Rezai-Zadeh K, Weitz TM, Rentsendorj A, Gate D, Spivak I, Bholat Y, Vasilevko V, Glabe CG, Breunig JJ, Rakic P, Davtyan H, Agadjanyan MG, Kepe V, Barrio JR, Bannykh S, Szekely CA, Pechnick RN, Town T. A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric aß, and frank neuronal loss. J Neurosci. 2013 Apr 10; 33(15):6245-56. PMID: 23575824.
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    20. Guadiana SM, Semple-Rowland S, Daroszewski D, Madorsky I, Breunig JJ, Mykytyn K, Sarkisian MR. Arborization of dendrites by developing neocortical neurons is dependent on primary cilia and type 3 adenylyl cyclase. J Neurosci. 2013 Feb 06; 33(6):2626-38. PMID: 23392690.
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    21. Breunig JJ, Gate D, Levy R, Rodriguez J, Kim GB, Danielpour M, Svendsen CN, Town T. Rapid genetic targeting of pial surface neural progenitors and immature neurons by neonatal electroporation. Neural Dev. 2012 Jul 10; 7:26. PMID: 22776033.
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    22. Gate D, Danielpour M, Levy R, Breunig JJ, Town T. Basic biology and mechanisms of neural ciliogenesis and the B9 family. Mol Neurobiol. 2012 Jun; 45(3):564-70. PMID: 22644387.
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    23. Arellano JI, Guadiana SM, Breunig JJ, Rakic P, Sarkisian MR. Development and distribution of neuronal cilia in mouse neocortex. J Comp Neurol. 2012 Mar 01; 520(4):848-73. PMID: 22020803.
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    24. Rash BG, Lim HD, Breunig JJ, Vaccarino FM. FGF signaling expands embryonic cortical surface area by regulating Notch-dependent neurogenesis. J Neurosci. 2011 Oct 26; 31(43):15604-17. PMID: 22031906.
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    25. Anastas SB, Mueller D, Semple-Rowland SL, Breunig JJ, Sarkisian MR. Failed cytokinesis of neural progenitors in citron kinase-deficient rats leads to multiciliated neurons. Cereb Cortex. 2011 Feb; 21(2):338-44. PMID: 20525772.
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    26. Breunig JJ, Arellano JI, Rakic P. Cilia in the brain: going with the flow. Nat Neurosci. 2010 Jun; 13(6):654-5. PMID: 20498683.
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    27. Rakic P, Ayoub AE, Breunig JJ, Dominguez MH. Decision by division: making cortical maps. Trends Neurosci. 2009 May; 32(5):291-301. PMID: 19380167.
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    28. Breunig JJ, Sarkisian MR, Arellano JI, Morozov YM, Ayoub AE, Sojitra S, Wang B, Flavell RA, Rakic P, Town T. Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling. Proc Natl Acad Sci U S A. 2008 Sep 02; 105(35):13127-32. PMID: 18728187.
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    29. Town T, Breunig JJ, Sarkisian MR, Spilianakis C, Ayoub AE, Liu X, Ferrandino AF, Gallagher AR, Li MO, Rakic P, Flavell RA. The stumpy gene is required for mammalian ciliogenesis. Proc Natl Acad Sci U S A. 2008 Feb 26; 105(8):2853-8. PMID: 18287022.
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    30. Rasin MR, Gazula VR, Breunig JJ, Kwan KY, Johnson MB, Liu-Chen S, Li HS, Jan LY, Jan YN, Rakic P, Sestan N. Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors. Nat Neurosci. 2007 Jul; 10(7):819-27. PMID: 17589506.
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