Frank Pajonk

Title(s)Professor, Radiation Oncology
SchoolMedicine
ORCID ORCID Icon0000-0003-4067-9751 Additional info
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    Other Positions
    Title(s)Professor, Neurosurgery


    Collapse Biography 
    Collapse Education and Training
    Albert-Ludwigs University, Freiburg, GermanyMD
    Albert-Ludwigs University, Freiburg, GermanyPhD
    Albert-Ludwigs University , Freiburg, Germany Venia Legendi
    Albert-Ludwigs University, Freiburg, GermanyHabilitation

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Use of CTEP portfolio compounds to counteract phenotype conversion in GBM
    NIH/NCI R01CA260886Jan 1, 2022 - Dec 30, 2027
    Role: PI
    UCLA SPORE in Brain Cancer
    NIH P50CA211015Aug 11, 2017 - Jul 31, 2022
    Role: Co-Investigator
    Glioblastoma, Glioblastoma Stem Cells and Radiotherapy
    NIH R01CA200234Aug 3, 2016 - Jul 31, 2021
    Role: Principal Investigator
    Erythropoietin and Breast Cancer Stem Cells
    NIH R01CA161294Jul 9, 2012 - Oct 31, 2017
    Role: Principal Investigator
    The 26S Proteasome in Cancer Stem Cells
    NIH R01CA137110Sep 23, 2009 - Jul 31, 2014
    Role: Principal Investigator
    The UCLA Center for Medical Countermeasures Against Radiation
    NIH U19AI067769Aug 31, 2005 - Jul 31, 2021
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Nicotinamide Adenine Dinucleotide Phosphate Oxidase Promotes Glioblastoma Radiation Resistance in a Phosphate and Tensin Homolog-Dependent Manner. Antioxid Redox Signal. 2023 Oct 25. Ludwig K, Le Belle JE, Muthukrishnan SD, Sperry J, Condro M, Vlashi E, Pajonk F, Kornblum HI. PMID: 37470216.
      View in: PubMed   Mentions:    Fields:    
    2. Activation of the mevalonate pathway in response to anti-cancer treatments drives glioblastoma recurrences through activation of Rac-1. bioRxiv. 2023 Jul 25. He L, Ioannidis A, Arambula E, Hoffman CJ, Joshi P, Kathiravan A, Whitelegge J, Liau LM, Kornblum HI, Pajonk F. PMID: 37546917; PMCID: PMC10402033.
      View in: PubMed   Mentions:
    3. Effects of Dopamine Receptor Antagonists and Radiation on Mouse Neural Stem/Progenitor Cells. bioRxiv. 2023 Jan 20. He L, Bhat K, Ioannidis A, Pajonk F. PMID: 36712018; PMCID: PMC9882258.
      View in: PubMed   Mentions:
    4. Factors predicting admission of psychiatric emergency contacts after presenting to the emergency department: results of a regression analysis. Ann Gen Psychiatry. 2022 Nov 09; 21(1):42. Kirchner H, Schaefer M, Ullrich H, Hulsmans N, Juckel G, Brzoska P, Pajonk FB. PMID: 36352413; PMCID: PMC9647959.
      View in: PubMed   Mentions:
    5. P300 promotes tumor recurrence by regulating radiation-induced conversion of glioma stem cells to vascular-like cells. Nat Commun. 2022 Oct 19; 13(1):6202. Muthukrishnan SD, Kawaguchi R, Nair P, Prasad R, Qin Y, Johnson M, Wang Q, VanderVeer-Harris N, Pham A, Alvarado AG, Condro MC, Gao F, Gau R, Castro MG, Lowenstein PR, Deb A, Hinman JD, Pajonk F, Burns TC, Goldman SA, Geschwind DH, Kornblum HI. PMID: 36261421; PMCID: PMC9582000.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    6. [Excited Delirium Syndrome (ExDS): emergence and emergency management]. Dtsch Med Wochenschr. 2021 10; 146(21):1421-1426. Hölzle P, Frank A, Hörmann S, Pajonk FG, Förstl H. PMID: 34670285.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    7. Dopamine Receptor Antagonists, Radiation, and Cholesterol Biosynthesis in Mouse Models of Glioblastoma. J Natl Cancer Inst. 2021 08 02; 113(8):1094-1104. Bhat K, Saki M, Cheng F, He L, Zhang L, Ioannidis A, Nathanson D, Tsang J, Bensinger SJ, Nghiemphu PL, Cloughesy TF, Liau LM, Kornblum HI, Pajonk F. PMID: 33556960; PMCID: PMC8328983.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    8. Effects of the DRD2/3 antagonist ONC201 and radiation in glioblastoma. Radiother Oncol. 2021 08; 161:140-147. He L, Bhat K, Ioannidis A, Zhang L, Nguyen NT, Allen JE, Nghiemphu PL, Cloughesy TF, Liau LM, Kornblum HI, Pajonk F. PMID: 34097975; PMCID: PMC8480533.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    9. Targeting Glioma Stem Cells. Neurosurg Clin N Am. 2021 Apr; 32(2):283-289. Muftuoglu Y, Pajonk F. PMID: 33781508; PMCID: PMC8010221.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    10. Tumor necrosis factor receptor signaling modulates carcinogenesis in a mouse model of breast cancer. Neoplasia. 2021 02; 23(2):197-209. He L, Bhat K, Duhacheck-Muggy S, Ioannidis A, Zhang L, Nguyen NT, Moatamed NA, Pajonk F. PMID: 33383310; PMCID: PMC7779542.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    11. 1-[(4-Nitrophenyl)sulfonyl]-4-phenylpiperazine treatment after brain irradiation preserves cognitive function in mice. Neuro Oncol. 2020 10 14; 22(10):1484-1494. Bhat K, Medina P, He L, Zhang L, Saki M, Ioannidis A, Nguyen NT, Sodhi SS, Sung D, Magyar CE, Liau LM, Kornblum HI, Pajonk F. PMID: 32291451; PMCID: PMC7566405.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    12. The dopamine receptor antagonist trifluoperazine prevents phenotype conversion and improves survival in mouse models of glioblastoma. Proc Natl Acad Sci U S A. 2020 05 19; 117(20):11085-11096. Bhat K, Saki M, Vlashi E, Cheng F, Duhachek-Muggy S, Alli C, Yu G, Medina P, He L, Damoiseaux R, Pellegrini M, Zemke NR, Nghiemphu PL, Cloughesy TF, Liau LM, Kornblum HI, Pajonk F. PMID: 32358191; PMCID: PMC7245100.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    13. Effects of Brain Irradiation in Immune-Competent and Immune-Compromised Mouse Models. Radiat Res. 2020 02; 193(2):186-194. Saki M, Bhat K, Sodhi SS, Nguyen NT, Kornblum HI, Pajonk F. PMID: 31774721; PMCID: PMC7135898.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    14. Radiation mitigation of the intestinal acute radiation injury in mice by 1-[(4-nitrophenyl)sulfonyl]-4-phenylpiperazine. Stem Cells Transl Med. 2020 01; 9(1):106-119. Duhachek-Muggy S, Bhat K, Medina P, Cheng F, He L, Alli C, Saki M, Muthukrishnan SD, Ruffenach G, Eghbali M, Vlashi E, Pajonk F. PMID: 31464098; PMCID: PMC6954722.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsPHPublic Health
    15. PK-M2-mediated metabolic changes in breast cancer cells induced by ionizing radiation. Breast Cancer Res Treat. 2019 Nov; 178(1):75-86. Zhang L, Bailleul J, Yazal T, Dong K, Sung D, Dao A, Gosa L, Nathanson D, Bhat K, Duhachek-Muggy S, Alli C, Dratver MB, Pajonk F, Vlashi E. PMID: 31372790; PMCID: PMC6790295.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    16. If It Seems Too Good to Be True…. Int J Radiat Oncol Biol Phys. 2019 02 01; 103(2):305-307. Steinberg ML, McBride WH, Vlashi E, Pajonk F. PMID: 30647007.
      View in: PubMed   Mentions:    Fields:    
    17. Serum erythropoietin levels, breast cancer and breast cancer-initiating cells. Breast Cancer Res. 2019 01 30; 21(1):17. Bhat K, Sandler K, Duhachek-Muggy S, Alli C, Cheng F, Moatamed NA, Magyar CE, Du L, Li G, McCloskey S, Vlashi E, Pajonk F. PMID: 30700319; PMCID: PMC6354373.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    18. Fortschr Neurol Psychiatr. 2018 12; 86(12):742-743. Messer T, Pajonk FB, Schmauß M. PMID: 30616254.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. 1-(4-nitrobenzenesulfonyl)-4-penylpiperazine increases the number of Peyer's patch-associated regenerating crypts in the small intestines after radiation injury. Radiother Oncol. 2019 03; 132:8-15. Bhat K, Duhachek-Muggy S, Ramanathan R, Saki M, Alli C, Medina P, Damoiseaux R, Whitelegge J, McBride WH, Schaue D, Vlashi E, Pajonk F. PMID: 30825974; PMCID: PMC6400303.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsPHPublic Health
    20. Mebendazole Potentiates Radiation Therapy in Triple-Negative Breast Cancer. Int J Radiat Oncol Biol Phys. 2019 01 01; 103(1):195-207. Zhang L, Bochkur Dratver M, Yazal T, Dong K, Nguyen A, Yu G, Dao A, Bochkur Dratver M, Duhachek-Muggy S, Bhat K, Alli C, Pajonk F, Vlashi E. PMID: 30196056; PMCID: PMC6457649.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    21. Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities. Cancer Metab. 2018; 6:4. Garrett M, Sperry J, Braas D, Yan W, Le TM, Mottahedeh J, Ludwig K, Eskin A, Qin Y, Levy R, Breunig JJ, Pajonk F, Graeber TG, Radu CG, Christofk H, Prins RM, Lai A, Liau LM, Coppola G, Kornblum HI. PMID: 29692895; PMCID: PMC5905129.
      View in: PubMed   Mentions: 34  
    22. The Future of Radiobiology. J Natl Cancer Inst. 2018 04 01; 110(4):329-340. Kirsch DG, Diehn M, Kesarwala AH, Maity A, Morgan MA, Schwarz JK, Bristow R, Demaria S, Eke I, Griffin RJ, Haas-Kogan D, Higgins GS, Kimmelman AC, Kimple RJ, Lombaert IM, Ma L, Marples B, Pajonk F, Park CC, Schaue D, Tran PT, Bernhard EJ. PMID: 29126306; PMCID: PMC5928778.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    23. Radioresistance of the breast tumor is highly correlated to its level of cancer stem cell and its clinical implication for breast irradiation. Radiother Oncol. 2017 09; 124(3):455-461. Qi XS, Pajonk F, McCloskey S, Low DA, Kupelian P, Steinberg M, Sheng K. PMID: 28923575; PMCID: PMC6128144.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    24. Growth Differentiation Factor 11 does not Mitigate the Lethal Effects of Total-Abdominal Irradiation. Radiat Res. 2017 11; 188(5):469-475. Duhachek-Muggy S, Bhat K, Vlashi E, Pajonk F. PMID: 28829672; PMCID: PMC5709091.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    25. Radiation-Induced Dedifferentiation of Head and Neck Cancer Cells Into Cancer Stem Cells Depends on Human Papillomavirus Status. Int J Radiat Oncol Biol Phys. 2016 Apr 01; 94(5):1198-206. Vlashi E, Chen AM, Boyrie S, Yu G, Nguyen A, Brower PA, Hess CB, Pajonk F. PMID: 27026319; PMCID: PMC4817367.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    26. Incorporating cancer stem cells in radiation therapy treatment response modeling and the implication in glioblastoma multiforme treatment resistance. Int J Radiat Oncol Biol Phys. 2015 Mar 15; 91(4):866-75. Yu VY, Nguyen D, Pajonk F, Kupelian P, Kaprealian T, Selch M, Low DA, Sheng K. PMID: 25752402.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    27. The metabolic state of cancer stem cells-a valid target for cancer therapy? Free Radic Biol Med. 2015 Feb; 79:264-8. Vlashi E, Pajonk F. PMID: 25450330; PMCID: PMC4339632.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    28. Cancer stem cells, cancer cell plasticity and radiation therapy. Semin Cancer Biol. 2015 Apr; 31:28-35. Vlashi E, Pajonk F. PMID: 25025713; PMCID: PMC4291301.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansCells
    29. Metabolic differences in breast cancer stem cells and differentiated progeny. Breast Cancer Res Treat. 2014 Aug; 146(3):525-34. Vlashi E, Lagadec C, Vergnes L, Reue K, Frohnen P, Chan M, Alhiyari Y, Dratver MB, Pajonk F. PMID: 25007966; PMCID: PMC4131557.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    30. Tumor cells with low proteasome subunit expression predict overall survival in head and neck cancer patients. BMC Cancer. 2014 Mar 05; 14:152. Lagadec C, Vlashi E, Bhuta S, Lai C, Mischel P, Werner M, Henke M, Pajonk F. PMID: 24593279; PMCID: PMC3975871.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    31. The RNA-binding protein Musashi-1 regulates proteasome subunit expression in breast cancer- and glioma-initiating cells. Stem Cells. 2014 Jan; 32(1):135-44. Lagadec C, Vlashi E, Frohnen P, Alhiyari Y, Chan M, Pajonk F. PMID: 24022895; PMCID: PMC3968686.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    32. Characterization of the stem cell niche and its importance in radiobiological response. Semin Radiat Oncol. 2013 Oct; 23(4):237-41. Pajonk F, Vlashi E. PMID: 24012337; PMCID: PMC3768002.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    33. Targeted elimination of breast cancer cells with low proteasome activity is sufficient for tumor regression. Breast Cancer Res Treat. 2013 Sep; 141(2):197-203. Vlashi E, Lagadec C, Chan M, Frohnen P, McDonald AJ, Pajonk F. PMID: 24013708; PMCID: PMC3814133.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    34. Radiation-induced Notch signaling in breast cancer stem cells. Int J Radiat Oncol Biol Phys. 2013 Nov 01; 87(3):609-18. Lagadec C, Vlashi E, Alhiyari Y, Phillips TM, Bochkur Dratver M, Pajonk F. PMID: 23992604; PMCID: PMC3788036.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    35. National Institutes of Health funding in radiation oncology: a snapshot. Int J Radiat Oncol Biol Phys. 2013 Jun 01; 86(2):234-40. Steinberg M, McBride WH, Vlashi E, Pajonk F. PMID: 23523324; PMCID: PMC3646925.
      View in: PubMed   Mentions: 14     Fields:    
    36. The effect of aerobic exercise on cortical architecture in patients with chronic schizophrenia: a randomized controlled MRI study. Eur Arch Psychiatry Clin Neurosci. 2013 Sep; 263(6):469-73. Falkai P, Malchow B, Wobrock T, Gruber O, Schmitt A, Honer WG, Pajonk FG, Sun F, Cannon TD. PMID: 23161338.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    37. Catch-22: does breast cancer radiotherapy have negative impacts too? Future Oncol. 2012 Jun; 8(6):643-5. Lagadec C, Pajonk F. PMID: 22764760.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    38. Radiation-induced reprogramming of breast cancer cells. Stem Cells. 2012 May; 30(5):833-44. Lagadec C, Vlashi E, Della Donna L, Dekmezian C, Pajonk F. PMID: 22489015; PMCID: PMC3413333.
      View in: PubMed   Mentions: 187     Fields:    Translation:HumansCells
    39. Oxygen levels do not determine radiation survival of breast cancer stem cells. PLoS One. 2012; 7(3):e34545. Lagadec C, Dekmezian C, Bauché L, Pajonk F. PMID: 22479642; PMCID: PMC3315542.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    40. Trauma and stress-related disorders in German emergency physicians: the predictive role of personality factors. Int J Emerg Ment Health. 2012; 14(4):257-68. Pajonk FG, Cransac P, Müller V, Teichmann A, Meyer W. PMID: 23980490.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    41. Radioresistance of prostate cancer cells with low proteasome activity. Prostate. 2012 Jun 01; 72(8):868-74. Della Donna L, Lagadec C, Pajonk F. PMID: 21932424; PMCID: PMC3396561.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    42. Metabolic state of glioma stem cells and nontumorigenic cells. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):16062-7. Vlashi E, Lagadec C, Vergnes L, Matsutani T, Masui K, Poulou M, Popescu R, Della Donna L, Evers P, Dekmezian C, Reue K, Christofk H, Mischel PS, Pajonk F. PMID: 21900605; PMCID: PMC3179043.
      View in: PubMed   Mentions: 277     Fields:    Translation:HumansCells
    43. Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trials. Curr Cancer Drug Targets. 2011 Mar; 11(3):254-84. Potts BC, Albitar MX, Anderson KC, Baritaki S, Berkers C, Bonavida B, Chandra J, Chauhan D, Cusack JC, Fenical W, Ghobrial IM, Groll M, Jensen PR, Lam KS, Lloyd GK, McBride W, McConkey DJ, Miller CP, Neuteboom ST, Oki Y, Ovaa H, Pajonk F, Richardson PG, Roccaro AM, Sloss CM, Spear MA, Valashi E, Younes A, Palladino MA. PMID: 21247382; PMCID: PMC3712795.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimals
    44. Irradiation of the potential cancer stem cell niches in the adult brain improves progression-free survival of patients with malignant glioma. BMC Cancer. 2010 Jul 21; 10:384. Evers P, Lee PP, DeMarco J, Agazaryan N, Sayre JW, Selch M, Pajonk F. PMID: 20663133; PMCID: PMC2918578.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    45. Radiation resistance of cancer stem cells: the 4 R's of radiobiology revisited. Stem Cells. 2010 Apr; 28(4):639-48. Pajonk F, Vlashi E, McBride WH. PMID: 20135685; PMCID: PMC2940232.
      View in: PubMed   Mentions: 153     Fields:    Translation:HumansAnimalsCells
    46. Survival and self-renewing capacity of breast cancer initiating cells during fractionated radiation treatment. Breast Cancer Res. 2010; 12(1):R13. Lagadec C, Vlashi E, Della Donna L, Meng Y, Dekmezian C, Kim K, Pajonk F. PMID: 20158881; PMCID: PMC2880434.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
    47. Targeted cancer stem cell therapies start with proper identification of the target. Mol Cancer Res. 2010 Feb; 8(2):291; author reply 291. Vlashi E, Pajonk F. PMID: 20145040; PMCID: PMC2824786.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    48. Differential Effects of the Proteasome Inhibitor NPI-0052 against Glioma Cells. Transl Oncol. 2010 Feb; 3(1):50-5. Vlashi E, Mattes M, Lagadec C, Donna LD, Phillips TM, Nikolay P, McBride WH, Pajonk F. PMID: 20165695; PMCID: PMC2822455.
      View in: PubMed   Mentions: 14  
    49. Radiation responses of cancer stem cells. J Cell Biochem. 2009 Oct 01; 108(2):339-42. Vlashi E, McBride WH, Pajonk F. PMID: 19623582; PMCID: PMC2865474.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    50. Radiation Therapy Oncology Group translational research program stem cell symposium: incorporating stem cell hypotheses into clinical trials. Int J Radiat Oncol Biol Phys. 2009 Aug 01; 74(5):1580-91. Woodward WA, Bristow RG, Clarke MF, Coppes RP, Cristofanilli M, Duda DG, Fike JR, Hambardzumyan D, Hill RP, Jordan CT, Milas L, Pajonk F, Curran WJ, Dicker AP, Chen Y. PMID: 19540073.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    51. In vivo imaging, tracking, and targeting of cancer stem cells. J Natl Cancer Inst. 2009 Mar 04; 101(5):350-9. Vlashi E, Kim K, Lagadec C, Donna LD, McDonald JT, Eghbali M, Sayre JW, Stefani E, McBride W, Pajonk F. PMID: 19244169; PMCID: PMC2727141.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansAnimalsCells
    52. [Substance-abuse related emergencies--illegal drugs, part II]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2009 Jan; 44(1):14-20. Kinn M, Holzbach R, Pajonk FG. PMID: 19115183.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    53. [Substance-abuse related emergencies--illegal drugs, part I]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2008 Nov; 43(11-12):746-53. Kinn M, Holzbach R, Pajonk FG. PMID: 19016385.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    54. Effect of copper intake on CSF parameters in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial. J Neural Transm (Vienna). 2008 Dec; 115(12):1651-9. Kessler H, Pajonk FG, Bach D, Schneider-Axmann T, Falkai P, Herrmann W, Multhaup G, Wiltfang J, Schäfer S, Wirths O, Bayer TA. PMID: 18972062.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCellsCTClinical Trials
    55. [Alcohol-related disorders in the preclinical medicine]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2008 Oct; 43(10):664-73. Kinn M, Holzbach R, Pajonk FG. PMID: 18958818.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    56. Identifying the profile of optimal candidates for antipsychotic depot therapy A cluster analysis. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Dec 12; 32(8):1987-93. Heres S, Hamann J, Mendel R, Wickelmaier F, Pajonk FG, Leucht S, Kissling W. PMID: 18948163.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    57. [Psychosocial emergencies--Agitation, aggression and violence in emergency and search and rescue services]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2008 Jul; 43(7-8):514-21. Pajonk FG, D'Amelio R. PMID: 18671172.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    58. Psychiatric emergencies in prehospital emergency medical systems: a prospective comparison of two urban settings. Gen Hosp Psychiatry. 2008 Jul-Aug; 30(4):360-6. Pajonk FG, Schmitt P, Biedler A, Richter JC, Meyer W, Luiz T, Madler C. PMID: 18585541.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    59. Intake of copper has no effect on cognition in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial. J Neural Transm (Vienna). 2008 Aug; 115(8):1181-7. Kessler H, Bayer TA, Bach D, Schneider-Axmann T, Supprian T, Herrmann W, Haber M, Multhaup G, Falkai P, Pajonk FG. PMID: 18587525; PMCID: PMC2516533.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCTClinical Trials
    60. The dilemma of insight into illness in schizophrenia: self- and expert-rated insight and quality of life. Eur Arch Psychiatry Clin Neurosci. 2008 Apr; 258(3):152-9. Karow A, Pajonk FG, Reimer J, Hirdes F, Osterwald C, Naber D, Moritz S. PMID: 18000637.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    61. [Postoperative delirium in the critically ill]. Anaesthesist. 2008 Apr; 57(4):403-29; quiz 430-1. Schmitt TK, Pajonk FG. PMID: 18414917.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    62. Effects of recombinant erythropoietin on breast cancer-initiating cells. Neoplasia. 2007 Dec; 9(12):1122-9. Phillips TM, Kim K, Vlashi E, McBride WH, Pajonk F. PMID: 18084619; PMCID: PMC2134908.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    63. The attitude of patients towards antipsychotic depot treatment. Int Clin Psychopharmacol. 2007 Sep; 22(5):275-82. Heres S, Schmitz FS, Leucht S, Pajonk FG. PMID: 17690596.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    64. Copper and clioquinol treatment in young APP transgenic and wildtype mice: effects on life expectancy, body weight and metal-ion levels. J Mol Med (Berl). 2007 Apr; 85(4):421. Schäfer S, Pajonk FG, Multhaup G, Bayer TA. PMID: 27517708.
      View in: PubMed   Mentions:    Fields:    
    65. Second-generation antipsychotic agents in the treatment of acute mania: a systematic review and meta-analysis of randomized controlled trials. Arch Gen Psychiatry. 2007 Apr; 64(4):442-55. Scherk H, Pajonk FG, Leucht S. PMID: 17404121.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    66. Copper and clioquinol treatment in young APP transgenic and wild-type mice: effects on life expectancy, body weight, and metal-ion levels. J Mol Med (Berl). 2007 Apr; 85(4):405-13. Schäfer S, Pajonk FG, Multhaup G, Bayer TA. PMID: 17211610.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    67. The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation. J Natl Cancer Inst. 2006 Dec 20; 98(24):1777-85. Phillips TM, McBride WH, Pajonk F. PMID: 17179479.
      View in: PubMed   Mentions: 622     Fields:    Translation:HumansCells
    68. The effects of tea extracts on proinflammatory signaling. BMC Med. 2006 Dec 01; 4:28. Pajonk F, Riedisser A, Henke M, McBride WH, Fiebich B. PMID: 17140430; PMCID: PMC1698929.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    69. The proteasome inhibitor MG-132 protects hypoxic SiHa cervical carcinoma cells after cyclic hypoxia/reoxygenation from ionizing radiation. Neoplasia. 2006 Dec; 8(12):1037-41. Pajonk F, Grumann T, McBride WH. PMID: 17217621; PMCID: PMC1783721.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    70. Insight and quality of life in schizophrenia: recent findings and treatment implications. Curr Opin Psychiatry. 2006 Nov; 19(6):637-41. Karow A, Pajonk FG. PMID: 17012945.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    71. Do erythropoietin receptors on cancer cells explain unexpected clinical findings? J Clin Oncol. 2006 Oct 10; 24(29):4708-13. Henke M, Mattern D, Pepe M, Bézay C, Weissenberger C, Werner M, Pajonk F. PMID: 17028293.
      View in: PubMed   Mentions: 59     Fields:    Translation:Humans
    72. Safety and efficacy of hyperbaric oxygen therapy for the treatment of interstitial cystitis: a randomized, sham controlled, double-blind trial. J Urol. 2006 Oct; 176(4 Pt 1):1442-6. van Ophoven A, Rossbach G, Pajonk F, Hertle L. PMID: 16952654.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    73. Cerebrospinal fluid diagnostic markers correlate with lower plasma copper and ceruloplasmin in patients with Alzheimer's disease. J Neural Transm (Vienna). 2006 Nov; 113(11):1763-9. Kessler H, Pajonk FG, Meisser P, Schneider-Axmann T, Hoffmann KH, Supprian T, Herrmann W, Obeid R, Multhaup G, Falkai P, Bayer TA. PMID: 16736242.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    74. Incidence of posttraumatic stress disorder after prolonged surgical intensive care unit treatment. Psychosomatics. 2006 May-Jun; 47(3):223-30. Richter JC, Waydhas C, Pajonk FG. PMID: 16684939.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    75. [Not Available]. MMW Fortschr Med. 2006 Jan; 148(4):35-8. Pajonk FG. PMID: 27387314.
      View in: PubMed   Mentions:    Fields:    
    76. Clinical trial design in schizophrenia: implications for clinical decisions. Curr Opin Psychiatry. 2005 Nov; 18(6):692-9. Pajonk FG. PMID: 16639099.
      View in: PubMed   Mentions: 2     Fields:    
    77. Rapid dose titration of quetiapine for the treatment of acute schizophrenia and acute mania: a case series. J Psychopharmacol. 2006 Jan; 20(1):119-24. Pajonk FG, Schwertner AK, Seelig MA. PMID: 16204326.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    78. Anthracyclines, proteasome activity and multi-drug-resistance. BMC Cancer. 2005 Sep 13; 5:114. Fekete MR, McBride WH, Pajonk F. PMID: 16159384; PMCID: PMC1242219.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    79. Cognitive decline correlates with low plasma concentrations of copper in patients with mild to moderate Alzheimer's disease. J Alzheimers Dis. 2005 Sep; 8(1):23-7. Pajonk FG, Kessler H, Supprian T, Hamzei P, Bach D, Schweickhardt J, Herrmann W, Obeid R, Simons A, Falkai P, Multhaup G, Bayer TA. PMID: 16155346.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    80. Risperidone: an open-label, observational study of the efficacy, tolerability, and prescribing behavior in acutely exacerbated patients with schizophrenia. J Clin Psychopharmacol. 2005 Aug; 25(4):293-300. Pajonk FG, Schreiner A, Peters S, Rettig K, Degner D, Rüther E. PMID: 16012270.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    81. The proteasome inhibitor MG-132 sensitizes PC-3 prostate cancer cells to ionizing radiation by a DNA-PK-independent mechanism. BMC Cancer. 2005 Jul 07; 5:76. Pajonk F, van Ophoven A, Weissenberger C, McBride WH. PMID: 16001975; PMCID: PMC1177933.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    82. Hyperthermia-induced proteasome inhibition and loss of androgen receptor expression in human prostate cancer cells. Cancer Res. 2005 Jun 01; 65(11):4836-43. Pajonk F, van Ophoven A, McBride WH. PMID: 15930304.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    83. [The role of copper in the pathophysiology of Alzheimer's disease]. Nervenarzt. 2005 May; 76(5):581-5. Kessler H, Pajonk FG, Supprian T, Falkai P, Multhaup G, Bayer TA. PMID: 15905983.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    84. [Longterm therapy of schizophrenia]. Fortschr Neurol Psychiatr. 2005 Apr; 73(4):218-31; quiz 232-4. Pajonk FG, Wobrock T, Falkai P. PMID: 15806439.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    85. Long-term follow-up after severe suicide attempt by multiple blunt trauma. Eur Psychiatry. 2005 Mar; 20(2):115-20. Pajonk FG, Ruchholtz S, Waydhas C, Schneider-Axmann T. PMID: 15797695.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    86. [Longterm therapy of schizophrenia]. Fortschr Neurol Psychiatr. 2005 Mar; 73(3):161-74; quiz 175-7. Pajonk FG, Wobrock T, Falkai P. PMID: 15747226.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    87. Hypericin-an inhibitor of proteasome function. Cancer Chemother Pharmacol. 2005 May; 55(5):439-46. Pajonk F, Scholber J, Fiebich B. PMID: 15672261.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    88. [Acute treatment of schizophrenia]. Fortschr Neurol Psychiatr. 2004 Dec; 72(12):705-23; quiz 724-6. Wobrock T, Falkai P, Pajonk FG. PMID: 15580535.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    89. The erythropoietin-receptor pathway modulates survival of cancer cells. Oncogene. 2004 Nov 25; 23(55):8987-91. Pajonk F, Weil A, Sommer A, Suwinski R, Henke M. PMID: 15480420.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    90. [Assessment of psychiatric emergencies by physicians in the pre-hospital emergency medical system. A re-evaluation after 7 years]. Anaesthesist. 2004 Aug; 53(8):709-16. Pajonk FG, Lubda J, Sittinger H, Moecke H, Andresen B, Von Knobelsdorff G. PMID: 15197466.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    91. Psychometric and psychopathological characterization of young male prison inmates with and without attention deficit/hyperactivity disorder. Eur Arch Psychiatry Clin Neurosci. 2004 Aug; 254(4):201-8. Retz W, Retz-Junginger P, Hengesch G, Schneider M, Thome J, Pajonk FG, Salahi-Disfan A, Rees O, Wender PH, Rösler M. PMID: 15309387.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    92. A sense of danger from radiation. Radiat Res. 2004 Jul; 162(1):1-19. McBride WH, Chiang CS, Olson JL, Wang CC, Hong JH, Pajonk F, Dougherty GJ, Iwamoto KS, Pervan M, Liao YP. PMID: 15222781.
      View in: PubMed   Mentions: 137     Fields:    Translation:HumansAnimalsPHPublic Health
    93. [Psychooncology. New aspects for urology]. Urologe A. 2004 Mar; 43(3):296-301. Köllner V, Lautenschläger KA, Pajonk FG. PMID: 15045189.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    94. [Schizophrenia]. Fortschr Neurol Psychiatr. 2004 Mar; 72(3):164-74. Wobrock T, Pajonk FG, Falkai P. PMID: 14999596.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    95. [Schizophrenia]. Fortschr Neurol Psychiatr. 2004 Feb; 72(2):98-113. Wobrock T, Pajonk FG, Falkai P. PMID: 14770350.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    96. Risperidone in acute and long-term therapy of schizophrenia--a clinical profile. Prog Neuropsychopharmacol Biol Psychiatry. 2004 Jan; 28(1):15-23. Pajonk FG. PMID: 14687852.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    97. The role of the ubiquitin/proteasome system in cellular responses to radiation. Oncogene. 2003 Sep 01; 22(37):5755-73. McBride WH, Iwamoto KS, Syljuasen R, Pervan M, Pajonk F. PMID: 12947384.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimals
    98. [Psychopharmacological treatment in the pre-clinical emergency medicine]. Anaesthesist. 2003 Jul; 52(7):577-85. Pajonk FG, Fleiter B. PMID: 12898042.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    99. Patients on atypical antipsychotic drugs: another high-risk group for type 2 diabetes. Diabetes Care. 2003 May; 26(5):1597-605. Lean ME, Pajonk FG. PMID: 12716824.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    100. [Initial use of risperidone in the treatment of acutely exacerbated schizophrenic patients--an interim analysis]. Fortschr Neurol Psychiatr. 2003 May; 71(5):249-54. Pajonk FG, Schreiner A, Peters S, Rettig K, Degner D, Rüther E. PMID: 12740756.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    101. The human immunodeficiency virus (HIV)-1 protease inhibitor saquinavir inhibits proteasome function and causes apoptosis and radiosensitization in non-HIV-associated human cancer cells. Cancer Res. 2002 Sep 15; 62(18):5230-5. Pajonk F, Himmelsbach J, Riess K, Sommer A, McBride WH. PMID: 12234989.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    102. Survival of AIDS patients with primary central nervous system lymphoma may be improved by the radiosensitizing effects of highly active antiretroviral therapy. AIDS. 2002 May 24; 16(8):1195-6. Pajonk F, McBride WH. PMID: 12004285.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    103. [Outcome of long-term intensive therapy of surgery patients]. Unfallchirurg. 2002 May; 105(5):423-30. Pajonk FG, Fischer A, Waydhas C, Bregenzer T, Schweiberer L. PMID: 12132203.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    104. Comparing the efficacy of atypical antipsychotics in open uncontrolled versus double-blind controlled trials in schizophrenia. Psychopharmacology (Berl). 2002 Jun; 162(1):29-36. Pajonk FG, Holzbach R, Naber D. PMID: 12107614.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    105. N-acetyl-L-cysteine inhibits 26S proteasome function: implications for effects on NF-kappaB activation. Free Radic Biol Med. 2002 Mar 15; 32(6):536-43. Pajonk F, Riess K, Sommer A, McBride WH. PMID: 11958954.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    106. Vitiligo at the sites of irradiation in a patient with Hodgkin's disease. Strahlenther Onkol. 2002 Mar; 178(3):159-62. Pajonk F, Weissenberger C, Witucki G, Henke M. PMID: 11962193.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    107. NF-kappa B, cytokines, proteasomes, and low-dose radiation exposure. Mil Med. 2002 Feb; 167(2 Suppl):66-7. McBride WH, Pajonk F, Chiang CS, Sun JR. PMID: 11873521.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    108. Suicides and suicide attempts in emergency medicine. Crisis. 2002; 23(2):68-73. Pajonk FG, Gruenberg KA, Moecke H, Naber D. PMID: 12500891.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    109. The proteasome in cancer biology and treatment. Radiat Res. 2001 Nov; 156(5 Pt 1):447-59. Pajonk F, McBride WH. PMID: 11604057.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    110. Improvement of schizophrenic patients' subjective well-being under atypical antipsychotic drugs. Schizophr Res. 2001 May 30; 50(1-2):79-88. Naber D, Moritz S, Lambert M, Pajonk FG, Holzbach R, Mass R, Andresen B, Rajonk F. PMID: 11378316.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCTClinical Trials
    111. Epithelial cells in the peripheral blood of patients with cancer of the head and neck: incidence, detection and possible clinical significance. Radiother Oncol. 2001 May; 59(2):213-7. Pajonk F, Schlessmann S, Guttenberger R, Henke M. PMID: 11325451.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    112. Ionizing radiation affects 26s proteasome function and associated molecular responses, even at low doses. Radiother Oncol. 2001 May; 59(2):203-12. Pajonk F, McBride WH. PMID: 11325450.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    113. [Evaluation of a training program "Psychiatry for EmergencyPhysicians"]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2001 Feb; 36(2):105-9. Pajonk FG, Riemenschneider O, Moecke H, Arbeitsgruppe Psychiatrie und Rettungswesen. PMID: 11269012.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    114. Comment on double-strand break repair and rapamycin treatment. Int J Radiat Biol. 2000 Dec; 76(12):1691-3. Pajonk F, McBride WH. PMID: 11133052.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    115. [Quality of life after long-term surgical intensive care treatment]. Anaesthesist. 2000 Sep; 49(9):822-8. Richter JC, Pajonk FG, Waydhas C, Bregenzer T. PMID: 11076271.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    116. Apoptosis and radiosensitization of hodgkin cells by proteasome inhibition. Int J Radiat Oncol Biol Phys. 2000 Jul 01; 47(4):1025-32. Pajonk F, Pajonk K, McBride WH. PMID: 10863075.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    117. [Open studies in comparison to controlled studies in testing of neuroleptics]. Fortschr Neurol Psychiatr. 2000 Jul; 68(7):313-20. Pajonk FG, Holzbach R, Naber D. PMID: 10945157.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    118. [DIVI emergency medicine protocol, version 4.0]. Anaesthesist. 2000 Mar; 49(3):211-3. Moecke H, Dirks B, Friedrich HJ, Hennes HJ, Lackner CK, Messelken M, Neumann C, Pajonk FG, Reng M, Schächinger U, Violka T. PMID: 10788991.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    119. Inhibition of NF-kappaB, clonogenicity, and radiosensitivity of human cancer cells. J Natl Cancer Inst. 1999 Nov 17; 91(22):1956-60. Pajonk F, Pajonk K, McBride WH. PMID: 10564680.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    120. Long-term results and quality of life after parasuicidal multiple blunt trauma. Crit Care Med. 1999 Mar; 27(3):522-30. Ruchholtz S, Pajonk FG, Waydhas C, Lewan U, Nast-Kolb D, Schweiberer L. PMID: 10199531.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    121. Erythropoietin for patients undergoing radiotherapy: a pilot study. Radiother Oncol. 1999 Feb; 50(2):185-90. Henke M, Guttenberger R, Barke A, Pajonk F, Pötter R, Frommhold H. PMID: 10368042.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCTClinical Trials
    122. Suicide attempts with mirtazapine overdose without complications. Biol Psychiatry. 1998 Nov 01; 44(9):925-6. Holzbach R, Jahn H, Pajonk FG, Mähne C. PMID: 9807651.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    123. [Psychiatric emergencies from the viewpoint of the emergency physician]. Anaesthesist. 1998 Jul; 47(7):588-94. Pajonk FG, Biberthaler P, Cordes O, Moecke HP. PMID: 9740933.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansPHPublic Health
    124. Postoperative pterygium prevention by radiotherapy with strontium-90 beta-rays. Front Radiat Ther Oncol. 1997; 30:259-64. Pajonk F, Flick H, Mittelviefhaus H, Slanina J. PMID: 9205909.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    125. Human immunodeficiency virus antibody test and seroprevalence in psychiatric patients. Acta Psychiatr Scand. 1994 May; 89(5):358-61. Naber D, Pajonk FG, Perro C, Löhmer B. PMID: 8067276.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
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