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Eghbali, Mansoureh

Title(s)Professor, Anesthesiology
Phone(310) 206-0345
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    Collapse Research 
    Collapse Research Activities and Funding
    Role of miR125 in pulmonary hypertension secondary to interstitial lung disease
    NIH/NHLBI R01HL147586Dec 1, 2019 - Nov 30, 2023
    Role: Principal Investigator
    Role of miR193 in oxidized lipid induced pulmonary hypertension
    NIH/NHLBI R01HL129051Aug 15, 2016 - Jun 30, 2020
    Role: Principal Investigator
    Epigenetic regulation of myocardial ischemia/reperfusion injury by X chromosome
    NIH/NHLBI R01HL131182Apr 15, 2016 - Mar 31, 2020
    Role: Principal Investigator
    Sex differences in myocardial ischemia/reperfusion injury
    NIH/NHLBI R56HL119886Jul 24, 2014 - Jun 30, 2015
    Role: Co-Principal Investigator
    Cardiac KCNE2 (MIRP1) Regulation by Estrogen and Cardiac Stress
    NIH/NHLBI R01HL089876Jul 14, 2008 - Jun 30, 2013
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Umar S, Ruffenach G, Moazeni S, Vaillancourt M, Hong J, Cunningham C, Cao N, Navab S, Sarji S, Li M, Lee L, Fishbein G, Ardehali A, Navab M, Reddy ST, Eghbali M. Involvement of Low-Density Lipoprotein Receptor in the Pathogenesis of Pulmonary Hypertension. J Am Heart Assoc. 2020 Jan 21; 9(2):e012063. PMID: 31914876.
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    2. Mikhael M, Makar C, Wissa A, Le T, Eghbali M, Umar S. Oxidative Stress and Its Implications in the Right Ventricular Remodeling Secondary to Pulmonary Hypertension. Front Physiol. 2019; 10:1233. PMID: 31607955.
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    3. Ruffenach G, Umar S, Vaillancourt M, Hong J, Cao N, Sarji S, Moazeni S, Cunningham CM, Ardehali A, Reddy ST, Saggar R, Fishbein G, Eghbali M. Histological hallmarks and role of Slug/PIP axis in pulmonary hypertension secondary to pulmonary fibrosis. EMBO Mol Med. 2019 09; 11(9):e10061. PMID: 31468711.
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    4. Duhachek-Muggy S, Bhat K, Medina P, Cheng F, He L, Alli C, Saki M, Muthukrishnan SD, Ruffenach G, Eghbali M, Vlashi E, Pajonk F. Radiation mitigation of the intestinal acute radiation injury in mice by 1-[(4-nitrophenyl)sulfonyl]-4-phenylpiperazine. Stem Cells Transl Med. 2020 Jan; 9(1):106-119. PMID: 31464098.
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    5. Medzikovic L, Aryan L, Eghbali M. Connecting sex differences, estrogen signaling, and microRNAs in cardiac fibrosis. J Mol Med (Berl). 2019 10; 97(10):1385-1398. PMID: 31448389.
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    6. Umar S, Eghbali M. In Reply. Anesthesiology. 2019 Mar; 130(3):519-521. PMID: 30762648.
      View in: PubMed
    7. Sulaiman D, Li J, Devarajan A, Cunningham CM, Li M, Fishbein GA, Fogelman AM, Eghbali M, Reddy ST. Paraoxonase 2 protects against acute myocardial ischemia-reperfusion injury by modulating mitochondrial function and oxidative stress via the PI3K/Akt/GSK-3ß RISK pathway. J Mol Cell Cardiol. 2019 Apr; 129:154-164. PMID: 30802459.
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    8. Iorga A, Umar S, Ruffenach G, Aryan L, Li J, Sharma S, Motayagheni N, Nadadur RD, Bopassa JC, Eghbali M. Estrogen rescues heart failure through estrogen receptor Beta activation. Biol Sex Differ. 2018 10 30; 9(1):48. PMID: 30376877.
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    9. Saddic LA, Howard-Quijano K, Kipke J, Kubo Y, Dale EA, Hoover D, Shivkumar K, Eghbali M, Mahajan A. Progression of myocardial ischemia leads to unique changes in immediate-early gene expression in the spinal cord dorsal horn. Am J Physiol Heart Circ Physiol. 2018 12 01; 315(6):H1592-H1601. PMID: 30216122.
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    10. Umar S, Li J, Hannabass K, Vaillancourt M, Cunningham CM, Moazeni S, Mahajan A, Eghbali M. Free Fatty Acid Receptor G-protein-coupled Receptor 40 Mediates Lipid Emulsion-induced Cardioprotection. Anesthesiology. 2018 07; 129(1):154-162. PMID: 29620570.
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    11. Umar S, Cunningham CM, Itoh Y, Moazeni S, Vaillancourt M, Sarji S, Centala A, Arnold AP, Eghbali M. The Y Chromosome Plays a Protective Role in Experimental Hypoxic Pulmonary Hypertension. Am J Respir Crit Care Med. 2018 04 01; 197(7):952-955. PMID: 28934553.
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    12. Cunningham CM, Eghbali M. An Introduction to Epigenetics in Cardiovascular Development, Disease, and Sexualization. Adv Exp Med Biol. 2018; 1065:31-47. PMID: 30051375.
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    13. Vaillancourt M, Chia P, Sarji S, Nguyen J, Hoftman N, Ruffenach G, Eghbali M, Mahajan A, Umar S. Autonomic nervous system involvement in pulmonary arterial hypertension. Respir Res. 2017 12 04; 18(1):201. PMID: 29202826.
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    14. Iorga A, Cunningham CM, Moazeni S, Ruffenach G, Umar S, Eghbali M. The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy. Biol Sex Differ. 2017 10 24; 8(1):33. PMID: 29065927.
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    15. Umar S, Partow-Navid R, Ruffenach G, Iorga A, Moazeni S, Eghbali M. Severe pulmonary hypertension in aging female apolipoprotein E-deficient mice is rescued by estrogen replacement therapy. Biol Sex Differ. 2017; 8:9. PMID: 28344760.
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    16. Arnold AP, Cassis LA, Eghbali M, Reue K, Sandberg K. Sex Hormones and Sex Chromosomes Cause Sex Differences in the Development of Cardiovascular Diseases. Arterioscler Thromb Vasc Biol. 2017 05; 37(5):746-756. PMID: 28279969.
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    17. Li J, Ruffenach G, Kararigas G, Cunningham CM, Motayagheni N, Barakai N, Umar S, Regitz-Zagrosek V, Eghbali M. Intralipid protects the heart in late pregnancy against ischemia/reperfusion injury via Caveolin2/STAT3/GSK-3ß pathway. J Mol Cell Cardiol. 2017 01; 102:108-116. PMID: 27847332.
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    18. Sharma S, Ruffenach G, Umar S, Motayagheni N, Reddy ST, Eghbali M. Role of oxidized lipids in pulmonary arterial hypertension. Pulm Circ. 2016 Sep; 6(3):261-73. PMID: 27683603.
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    19. Anwar A, Ruffenach G, Mahajan A, Eghbali M, Umar S. Novel biomarkers for pulmonary arterial hypertension. Respir Res. 2016 07 20; 17(1):88. PMID: 27439993.
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    20. Arnold AP, Reue K, Eghbali M, Vilain E, Chen X, Ghahramani N, Itoh Y, Li J, Link JC, Ngun T, Williams-Burris SM. The importance of having two X chromosomes. Philos Trans R Soc Lond B Biol Sci. 2016 Feb 19; 371(1688):20150113. PMID: 26833834.
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    21. Iorga A, Li J, Sharma S, Umar S, Bopassa JC, Nadadur RD, Centala A, Ren S, Saito T, Toro L, Wang Y, Stefani E, Eghbali M. Rescue of Pressure Overload-Induced Heart Failure by Estrogen Therapy. J Am Heart Assoc. 2016 Jan 22; 5(1). PMID: 26802104.
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    22. Ross DJ, Hough G, Hama S, Aboulhosn J, Belperio JA, Saggar R, Van Lenten BJ, Ardehali A, Eghbali M, Reddy S, Fogelman AM, Navab M. Proinflammatory high-density lipoprotein results from oxidized lipid mediators in the pathogenesis of both idiopathic and associated types of pulmonary arterial hypertension. Pulm Circ. 2015 Dec; 5(4):640-8. PMID: 26697171.
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    23. Sharma S, Umar S, Centala A, Eghbali M. Role of miR206 in genistein-induced rescue of pulmonary hypertension in monocrotaline model. J Appl Physiol (1985). 2015 Dec 15; 119(12):1374-82. PMID: 26472874.
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    24. Partownavid P, Sharma S, Li J, Umar S, Rahman S, Eghbali M. Involvement of Opioid Receptors in the Lipid Rescue of Bupivacaine-Induced Cardiotoxicity. Anesth Analg. 2015 Aug; 121(2):340-7. PMID: 25993392.
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    25. Sharma S, Umar S, Potus F, Iorga A, Wong G, Meriwether D, Breuils-Bonnet S, Mai D, Navab K, Ross D, Navab M, Provencher S, Fogelman AM, Bonnet S, Reddy ST, Eghbali M. Apolipoprotein A-I mimetic peptide 4F rescues pulmonary hypertension by inducing microRNA-193-3p. Circulation. 2014 Aug 26; 130(9):776-85. PMID: 24963038.
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    26. Li J, Chen X, McClusky R, Ruiz-Sundstrom M, Itoh Y, Umar S, Arnold AP, Eghbali M. The number of X chromosomes influences protection from cardiac ischaemia/reperfusion injury in mice: one X is better than two. Cardiovasc Res. 2014 Jun 01; 102(3):375-84. PMID: 24654234.
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    27. Li J, Bopassa JC, Rahman S, Eghbali M. In reply. Anesthesiology. 2013 May; 118(5):1238-40. PMID: 23612141.
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    28. Iorga A, Dewey S, Partow-Navid R, Gomes AV, Eghbali M. Pregnancy is associated with decreased cardiac proteasome activity and oxidative stress in mice. PLoS One. 2012; 7(11):e48601. PMID: 23166589.
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    29. Li J, Iorga A, Sharma S, Youn JY, Partow-Navid R, Umar S, Cai H, Rahman S, Eghbali M. Intralipid, a clinically safe compound, protects the heart against ischemia-reperfusion injury more efficiently than cyclosporine-A. Anesthesiology. 2012 Oct; 117(4):836-46. PMID: 22814384.
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    30. Umar S, Nadadur R, Iorga A, Amjedi M, Matori H, Eghbali M. Cardiac structural and hemodynamic changes associated with physiological heart hypertrophy of pregnancy are reversed postpartum. J Appl Physiol (1985). 2012 Oct 15; 113(8):1253-9. PMID: 22923507.
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    31. Partownavid P, Umar S, Li J, Rahman S, Eghbali M. Fatty-acid oxidation and calcium homeostasis are involved in the rescue of bupivacaine-induced cardiotoxicity by lipid emulsion in rats. Crit Care Med. 2012 Aug; 40(8):2431-7. PMID: 22647409.
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    32. Li J, Umar S, Amjedi M, Iorga A, Sharma S, Nadadur RD, Regitz-Zagrosek V, Eghbali M. New frontiers in heart hypertrophy during pregnancy. Am J Cardiovasc Dis. 2012; 2(3):192-207. PMID: 22937489.
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    33. Matori H, Umar S, Nadadur RD, Sharma S, Partow-Navid R, Afkhami M, Amjedi M, Eghbali M. Genistein, a soy phytoestrogen, reverses severe pulmonary hypertension and prevents right heart failure in rats. Hypertension. 2012 Aug; 60(2):425-30. PMID: 22753213.
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    34. Li J, Umar S, Iorga A, Youn JY, Wang Y, Regitz-Zagrosek V, Cai H, Eghbali M. Cardiac vulnerability to ischemia/reperfusion injury drastically increases in late pregnancy. Basic Res Cardiol. 2012 Jul; 107(4):271. PMID: 22648276.
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    35. Nadadur RD, Umar S, Wong G, Eghbali M, Iorga A, Matori H, Partow-Navid R, Eghbali M. Reverse right ventricular structural and extracellular matrix remodeling by estrogen in severe pulmonary hypertension. J Appl Physiol (1985). 2012 Jul; 113(1):149-58. PMID: 22628376.
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    36. Umar S, Rabinovitch M, Eghbali M. Estrogen paradox in pulmonary hypertension: current controversies and future perspectives. Am J Respir Crit Care Med. 2012 Jul 15; 186(2):125-31. PMID: 22561960.
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    37. Umar S, Lee JH, de Lange E, Iorga A, Partow-Navid R, Bapat A, van der Laarse A, Saggar R, Saggar R, Ypey DL, Karagueuzian HS, Eghbali M. Spontaneous ventricular fibrillation in right ventricular failure secondary to chronic pulmonary hypertension. Circ Arrhythm Electrophysiol. 2012 Feb; 5(1):181-90. PMID: 22199010.
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    38. Rahman S, Li J, Bopassa JC, Umar S, Iorga A, Partownavid P, Eghbali M. Phosphorylation of GSK-3ß mediates intralipid-induced cardioprotection against ischemia/reperfusion injury. Anesthesiology. 2011 Aug; 115(2):242-53. PMID: 21691195.
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    39. Umar S, Nadadur RD, Li J, Maltese F, Partownavid P, van der Laarse A, Eghbali M. Intralipid prevents and rescues fatal pulmonary arterial hypertension and right ventricular failure in rats. Hypertension. 2011 Sep; 58(3):512-8. PMID: 21747043.
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    40. Umar S, Iorga A, Matori H, Nadadur RD, Li J, Maltese F, van der Laarse A, Eghbali M. Estrogen rescues preexisting severe pulmonary hypertension in rats. Am J Respir Crit Care Med. 2011 Sep 15; 184(6):715-23. PMID: 21700911.
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    41. Wu Y, Eghbali M, Ou J, Lu R, Toro L, Stefani E. Quantitative determination of spatial protein-protein correlations in fluorescence confocal microscopy. Biophys J. 2010 Feb 03; 98(3):493-504. PMID: 20141764.
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    42. Bopassa JC, Eghbali M, Toro L, Stefani E. A novel estrogen receptor GPER inhibits mitochondria permeability transition pore opening and protects the heart against ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2010 Jan; 298(1):H16-23. PMID: 19880667.
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    43. Saito T, Ciobotaru A, Bopassa JC, Toro L, Stefani E, Eghbali M. Estrogen contributes to gender differences in mouse ventricular repolarization. Circ Res. 2009 Aug 14; 105(4):343-52. PMID: 19608983.
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    44. Vlashi E, Kim K, Lagadec C, Donna LD, McDonald JT, Eghbali M, Sayre JW, Stefani E, McBride W, Pajonk F. In vivo imaging, tracking, and targeting of cancer stem cells. J Natl Cancer Inst. 2009 Mar 04; 101(5):350-9. PMID: 19244169.
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    45. Helguera G, Eghbali M, Sforza D, Minosyan TY, Toro L, Stefani E. Changes in global gene expression in rat myometrium in transition from late pregnancy to parturition. Physiol Genomics. 2009 Jan 08; 36(2):89-97. PMID: 19001510.
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    46. Gomes AV, Young GW, Wang Y, Zong C, Eghbali M, Drews O, Lu H, Stefani E, Ping P. Contrasting proteome biology and functional heterogeneity of the 20 S proteasome complexes in mammalian tissues. Mol Cell Proteomics. 2009 Feb; 8(2):302-15. PMID: 18931337.
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    47. Lu R, Alioua A, Kumar Y, Kundu P, Eghbali M, Weisstaub NV, Gingrich JA, Stefani E, Toro L. c-Src tyrosine kinase, a critical component for 5-HT2A receptor-mediated contraction in rat aorta. J Physiol. 2008 Aug 15; 586(16):3855-69. PMID: 18599541.
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    48. Gomes P, Saito T, Del Corsso C, Alioua A, Eghbali M, Toro L, Stefani E. Identification of a functional interaction between Kv4.3 channels and c-Src tyrosine kinase. Biochim Biophys Acta. 2008 Oct; 1783(10):1884-92. PMID: 18620005.
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    49. Kundu P, Ciobotaru A, Foroughi S, Toro L, Stefani E, Eghbali M. Hormonal regulation of cardiac KCNE2 gene expression. Mol Cell Endocrinol. 2008 Sep 24; 292(1-2):50-62. PMID: 18611433.
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    50. Alioua A, Lu R, Kumar Y, Eghbali M, Kundu P, Toro L, Stefani E. Slo1 caveolin-binding motif, a mechanism of caveolin-1-Slo1 interaction regulating Slo1 surface expression. J Biol Chem. 2008 Feb 22; 283(8):4808-17. PMID: 18079116.
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    51. Minosyan TY, Lu R, Eghbali M, Toro L, Stefani E. Increased 5-HT contractile response in late pregnant rat myometrium is associated with a higher density of 5-HT2A receptors. J Physiol. 2007 May 15; 581(Pt 1):91-7. PMID: 17395633.
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    52. Cavalli A, Eghbali M, Minosyan TY, Stefani E, Philipson KD. Localization of sarcolemmal proteins to lipid rafts in the myocardium. Cell Calcium. 2007 Sep; 42(3):313-22. PMID: 17320949.
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    53. Eghbali M, Wang Y, Toro L, Stefani E. Heart hypertrophy during pregnancy: a better functioning heart? Trends Cardiovasc Med. 2006 Nov; 16(8):285-91. PMID: 17055385.
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    54. Ropero AB, Eghbali M, Minosyan TY, Tang G, Toro L, Stefani E. Heart estrogen receptor alpha: distinct membrane and nuclear distribution patterns and regulation by estrogen. J Mol Cell Cardiol. 2006 Sep; 41(3):496-510. PMID: 16876190.
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    55. Lu R, Alioua A, Kumar Y, Eghbali M, Stefani E, Toro L. MaxiK channel partners: physiological impact. J Physiol. 2006 Jan 01; 570(Pt 1):65-72. PMID: 16239267.
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    56. Zhu N, Eghbali M, Helguera G, Song M, Stefani E, Toro L. Alternative splicing of Slo channel gene programmed by estrogen, progesterone and pregnancy. FEBS Lett. 2005 Aug 29; 579(21):4856-60. PMID: 16102753.
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    57. Eghbali M, Deva R, Alioua A, Minosyan TY, Ruan H, Wang Y, Toro L, Stefani E. Molecular and functional signature of heart hypertrophy during pregnancy. Circ Res. 2005 Jun 10; 96(11):1208-16. PMID: 15905459.
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    58. Nishimaru K, Eghbali M, Lu R, Marijic J, Stefani E, Toro L. Functional and molecular evidence of MaxiK channel beta1 subunit decrease with coronary artery ageing in the rat. J Physiol. 2004 Sep 15; 559(Pt 3):849-62. PMID: 15272033.
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    59. Nishimaru K, Eghbali M, Stefani E, Toro L. Function and clustered expression of MaxiK channels in cerebral myocytes remain intact with aging. Exp Gerontol. 2004 May; 39(5):831-9. PMID: 15130678.
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    60. Eghbali M, Toro L, Stefani E. Diminished surface clustering and increased perinuclear accumulation of large conductance Ca2+-activated K+ channel in mouse myometrium with pregnancy. J Biol Chem. 2003 Nov 14; 278(46):45311-7. PMID: 12952984.
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