Hua Cai

Title(s)Professor, Anesthesiology
SchoolMedicine
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    Title(s)Professor, Medicine


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    Endothelium-driven signaling network in the development of pulmonary hypertension
    NIH R01HL154754Sep 1, 2020 - Jun 30, 2024
    Role: Principal Investigator
    Netrin-1 and Netrin-1 Preconditioned EPCs in Vascular Protection
    NIH R01HL142951Apr 1, 2020 - Jan 31, 2024
    Role: Principal Investigator
    Endothelium-Myocardium Interaction in Netrin-1 Induced Cardioprotection
    NIH R01HL119968Aug 1, 2013 - Jul 31, 2020
    Role: Principal Investigator
    Role of Vascular Oxidative Stress in Obesity
    NIH R01HL108701Feb 24, 2012 - Dec 31, 2017
    Role: Principal Investigator
    Mitochondrial pathways in NO induced cardioprotection
    NIH R01HL101228May 1, 2010 - Feb 28, 2015
    Role: Co-Principal Investigator
    NOXs, eNOS Uncoupling and Diabetic Atherogenesis
    NIH R01HL088975Apr 1, 2007 - Apr 30, 2021
    Role: Principal Investigator
    Endocardial dysfunction in humans with AF
    NIH R21HL081571Jul 1, 2005 - Jun 30, 2008
    Role: Principal Investigator
    Angiotensin II Uncoupling of Enos in Hypertension
    NIH R01HL077440Jul 1, 2004 - Jun 30, 2021
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Therapeutic application of estrogen for COVID-19: Attenuation of SARS-CoV-2 spike protein and IL-6 stimulated, ACE2-dependent NOX2 activation, ROS production and MCP-1 upregulation in endothelial cells. Redox Biol. 2021 10; 46:102099. Youn JY, Zhang Y, Wu Y, Cannesson M, Cai H. PMID: 34509916; PMCID: PMC8372492.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    2. Targeting MicroRNA-192-5p, a Downstream Effector of NOXs (NADPH Oxidases), Reverses Endothelial DHFR (Dihydrofolate Reductase) Deficiency to Attenuate Abdominal Aortic Aneurysm Formation. Hypertension. 2021 08; 78(2):282-293. Huang K, Narumi T, Zhang Y, Li Q, Murugesan P, Wu Y, Liu NM, Cai H. PMID: 34176283; PMCID: PMC8266749.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    3. Toll-Like Receptor 2 (TLR2) Knockout Abrogates Diabetic and Obese Phenotypes While Restoring Endothelial Function via Inhibition of NOX1. Diabetes. 2021 09; 70(9):2107-2119. Guo Z, Zhang Y, Liu C, Youn JY, Cai H. PMID: 34127487; PMCID: PMC8576422.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    4. More to Explore: Further Definition of Risk Factors for COPD - Differential Gender Difference, Modest Elevation in PM2.5, and e-Cigarette Use. Front Physiol. 2021; 12:669152. Zhang Y, Wang L, Mutlu GM, Cai H. PMID: 34025456; PMCID: PMC8131967.
      View in: PubMed   Mentions: 1  
    5. Traditional Chinese Medicine (TCM) in the treatment of COVID-19 and other viral infections: Efficacies and mechanisms. Pharmacol Ther. 2021 09; 225:107843. Huang K, Zhang P, Zhang Z, Youn JY, Wang C, Zhang H, Cai H. PMID: 33811957; PMCID: PMC8011334.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    6. Targeting feed-forward signaling of TGFβ/NOX4/DHFR/eNOS uncoupling/TGFβ axis with anti-TGFβ and folic acid attenuates formation of aortic aneurysms: Novel mechanisms and therapeutics. Redox Biol. 2021 01; 38:101757. Huang K, Wang Y, Siu KL, Zhang Y, Cai H. PMID: 33126053; PMCID: PMC7585948.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    7. More to Add to E-Cigarette Regulations: Unified Approaches. Chest. 2020 04; 157(4):771-773. Cai H, Garcia JGN, Wang C. PMID: 32252929.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    8. Sex difference and smoking predisposition in patients with COVID-19. Lancet Respir Med. 2020 04; 8(4):e20. Cai H. PMID: 32171067; PMCID: PMC7103991.
      View in: PubMed   Mentions: 246     Fields:    Translation:HumansCellsPHPublic Health
    9. Knockout of dihydrofolate reductase in mice induces hypertension and abdominal aortic aneurysm via mitochondrial dysfunction. Redox Biol. 2019 06; 24:101185. Li Q, Youn JY, Siu KL, Murugesan P, Zhang Y, Cai H. PMID: 30954686; PMCID: PMC6451172.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    10. Novel Treatment of Hypertension by Specifically Targeting E2F for Restoration of Endothelial Dihydrofolate Reductase and eNOS Function Under Oxidative Stress. Hypertension. 2019 01; 73(1):179-189. Li H, Li Q, Zhang Y, Liu W, Gu B, Narumi T, Siu KL, Youn JY, Liu P, Yang X, Cai H. PMID: 30571557; PMCID: PMC6310047.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    11. KDM4B protects against obesity and metabolic dysfunction. Proc Natl Acad Sci U S A. 2018 06 12; 115(24):E5566-E5575. Cheng Y, Yuan Q, Vergnes L, Rong X, Youn JY, Li J, Yu Y, Liu W, Cai H, Lin JD, Tontonoz P, Hong C, Reue K, Wang CY. PMID: 29844188; PMCID: PMC6004484.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    12. Surviving With Smog and Smoke: Precision Interventions? Chest. 2017 11; 152(5):925-929. Cai H, Wang C. PMID: 28694198; PMCID: PMC5812760.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansPHPublic Health
    13. Graphical review: The redox dark side of e-cigarettes; exposure to oxidants and public health concerns. Redox Biol. 2017 10; 13:402-406. Cai H, Wang C. PMID: 28667909; PMCID: PMC5493817.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsPHPublic Health
    14. Editorial commentary: Endothelial-to-mesenchymal transition: When the good one goes bad. Trends Cardiovasc Med. 2017 08; 27(6):394-396. Zhang Y, Cai H. PMID: 28583438; PMCID: PMC6529939.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Endothelial cell calpain as a critical modulator of angiogenesis. Biochim Biophys Acta Mol Basis Dis. 2017 06; 1863(6):1326-1335. Zhang Y, Liu NM, Wang Y, Youn JY, Cai H. PMID: 28366876; PMCID: PMC6511073.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    16. Attenuation of neointimal formation with netrin-1 and netrin-1 preconditioned endothelial progenitor cells. J Mol Med (Berl). 2017 03; 95(3):335-348. Liu NM, Siu KL, Youn JY, Cai H. PMID: 28004124; PMCID: PMC5976243.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    17. Protein Phosphotyrosine Phosphatase 1B (PTP1B) in Calpain-dependent Feedback Regulation of Vascular Endothelial Growth Factor Receptor (VEGFR2) in Endothelial Cells: IMPLICATIONS IN VEGF-DEPENDENT ANGIOGENESIS AND DIABETIC WOUND HEALING. J Biol Chem. 2017 Jan 13; 292(2):407-416. Zhang Y, Li Q, Youn JY, Cai H. PMID: 27872190; PMCID: PMC5241720.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    18. NOX isoforms in the development of abdominal aortic aneurysm. Redox Biol. 2017 04; 11:118-125. Siu KL, Li Q, Zhang Y, Guo J, Youn JY, Du J, Cai H. PMID: 27912196; PMCID: PMC5133668.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    19. Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure. Circulation. 2016 May 24; 133(21):2038-49. Sun H, Olson KC, Gao C, Prosdocimo DA, Zhou M, Wang Z, Jeyaraj D, Youn JY, Ren S, Liu Y, Rau CD, Shah S, Ilkayeva O, Gui WJ, William NS, Wynn RM, Newgard CB, Cai H, Xiao X, Chuang DT, Schulze PC, Lynch C, Jain MK, Wang Y. PMID: 27059949; PMCID: PMC4879058.
      View in: PubMed   Mentions: 149     Fields:    Translation:HumansAnimalsCells
    20. Differential Roles of Protein Complexes NOX1-NOXO1 and NOX2-p47phox in Mediating Endothelial Redox Responses to Oscillatory and Unidirectional Laminar Shear Stress. J Biol Chem. 2016 Apr 15; 291(16):8653-62. Siu KL, Gao L, Cai H. PMID: 26826128; PMCID: PMC4861435.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    21. Reply: To PMID 25882860. J Hypertens. 2015 Nov; 33(11):2368-70. Li Q, Youn JY, Li S, Cai H. PMID: 26372324; PMCID: PMC4819245.
      View in: PubMed   Mentions:    Fields:    
    22. Nifedipine attenuation of abdominal aortic aneurysm in hypertensive and non-hypertensive mice: Mechanisms and implications. J Mol Cell Cardiol. 2015 Oct; 87:152-9. Miao XN, Siu KL, Cai H. PMID: 26254182; PMCID: PMC4637219.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    23. Harnessing the Power of Integrated Mitochondrial Biology and Physiology: A Special Report on the NHLBI Mitochondria in Heart Diseases Initiative. Circ Res. 2015 Jul 17; 117(3):234-8. Ping P, Gustafsson ÅB, Bers DM, Blatter LA, Cai H, Jahangir A, Kelly D, Muoio D, O'Rourke B, Rabinovitch P, Trayanova N, Van Eyk J, Weiss JN, Wong R, Schwartz Longacre L. PMID: 26185209; PMCID: PMC4535701.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    24. Bone Morphogenic Protein 4 Mediates NOX1-Dependent eNOS Uncoupling, Endothelial Dysfunction, and COX2 Induction in Type 2 Diabetes Mellitus. Mol Endocrinol. 2015 Aug; 29(8):1123-33. Youn JY, Zhou J, Cai H. PMID: 26121233; PMCID: PMC4518001.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    25. Mechanisms and consequences of endothelial nitric oxide synthase dysfunction in hypertension. J Hypertens. 2015 Jun; 33(6):1128-36. Li Q, Youn JY, Cai H. PMID: 25882860; PMCID: PMC4816601.
      View in: PubMed   Mentions: 63     Fields:    Translation:Humans
    26. Induction of cardioprotection by small netrin-1-derived peptides. Am J Physiol Cell Physiol. 2015 Jul 15; 309(2):C100-6. Li Q, Cai H. PMID: 25924621; PMCID: PMC4504940.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    27. ANO1 taking center stage: blood pressure regulation in SHRs. J Mol Cell Cardiol. 2015 May; 82:216-7. Li Q, Cai H. PMID: 25817885; PMCID: PMC4819994.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    28. Fueling up skeletal muscle to reduce obesity: A TrkB story. Chem Biol. 2015 Mar 19; 22(3):311-2. Youn JY, Cai H. PMID: 25794433; PMCID: PMC4817994.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    29. Central role of SIAH inhibition in DCC-dependent cardioprotection provoked by netrin-1/NO. Proc Natl Acad Sci U S A. 2015 Jan 20; 112(3):899-904. Li Q, Wang P, Ye K, Cai H. PMID: 25561546; PMCID: PMC4311801.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    30. Circulating tetrahydrobiopterin as a novel biomarker for abdominal aortic aneurysm. Am J Physiol Heart Circ Physiol. 2014 Dec 01; 307(11):H1559-64. Siu KL, Cai H. PMID: 25260610; PMCID: PMC4255016.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    31. Netrin-1 abrogates ischemia/reperfusion-induced cardiac mitochondrial dysfunction via nitric oxide-dependent attenuation of NOX4 activation and recoupling of NOS. J Mol Cell Cardiol. 2015 Jan; 78:174-85. Siu KL, Lotz C, Ping P, Cai H. PMID: 25066694; PMCID: PMC4268247.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    32. NADPH oxidase 4 induces cardiac arrhythmic phenotype in zebrafish. J Biol Chem. 2014 Aug 15; 289(33):23200-23208. Zhang Y, Shimizu H, Siu KL, Mahajan A, Chen JN, Cai H. PMID: 24962575; PMCID: PMC4132817.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    33. Netrin-1 improves post-injury cardiac function in vivo via DCC/NO-dependent preservation of mitochondrial integrity, while attenuating autophagy. Biochim Biophys Acta. 2015 Feb; 1852(2):277-89. Bouhidel JO, Wang P, Siu KL, Li H, Youn JY, Cai H. PMID: 24928309; PMCID: PMC4262720.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    34. Role of vascular oxidative stress in obesity and metabolic syndrome. Diabetes. 2014 Jul; 63(7):2344-55. Youn JY, Siu KL, Lob HE, Itani H, Harrison DG, Cai H. PMID: 24550188; PMCID: PMC4066332.
      View in: PubMed   Mentions: 56     Fields:    Translation:Animals
    35. Recoupling of eNOS with folic acid prevents abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E null mice. PLoS One. 2014; 9(2):e88899. Siu KL, Miao XN, Cai H. PMID: 24558445; PMCID: PMC3928303.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    36. Pharmacological postconditioning treatment of myocardial infarction with netrin-1. Front Biosci (Landmark Ed). 2014 01 01; 19(3):566-70. Bouhidel JO, Wang P, Li Q, Cai H. PMID: 24389204; PMCID: PMC4053198.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    37. Oxidative stress in atrial fibrillation: an emerging role of NADPH oxidase. J Mol Cell Cardiol. 2013 Sep; 62:72-9. Youn JY, Zhang J, Zhang Y, Chen H, Liu D, Ping P, Weiss JN, Cai H. PMID: 23643589; PMCID: PMC3735724.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimals
    38. Inhibition of XO or NOX attenuates diethylstilbestrol-induced endothelial nitric oxide deficiency without affecting its effects on LNCaP cell invasion and apoptosis. Clin Sci (Lond). 2012 Oct; 123(8):509-18. Youn JY, Nguyen A, Cai H. PMID: 22568671; PMCID: PMC3675905.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    39. Intralipid, a clinically safe compound, protects the heart against ischemia-reperfusion injury more efficiently than cyclosporine-A. Anesthesiology. 2012 Oct; 117(4):836-46. Li J, Iorga A, Sharma S, Youn JY, Partow-Navid R, Umar S, Cai H, Rahman S, Eghbali M. PMID: 22814384; PMCID: PMC3769111.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    40. NOX4-Dependent Hydrogen Peroxide Overproduction in Human Atrial Fibrillation and HL-1 Atrial Cells: Relationship to Hypertension. Front Physiol. 2012; 3:140. Zhang J, Youn JY, Kim AY, Ramirez RJ, Gao L, Ngo D, Chen P, Scovotti J, Mahajan A, Cai H. PMID: 22679437; PMCID: PMC3367314.
      View in: PubMed   Mentions: 22  
    41. Perspectives on: SGP symposium on mitochondrial physiology and medicine: mitochondrial proteome design: from molecular identity to pathophysiological regulation. J Gen Physiol. 2012 Jun; 139(6):395-406. Zhang J, Lin A, Powers J, Lam MP, Lotz C, Liem D, Lau E, Wang D, Deng N, Korge P, Zong NC, Cai H, Weiss J, Ping P. PMID: 22641634; PMCID: PMC3362520.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    42. Cardiac vulnerability to ischemia/reperfusion injury drastically increases in late pregnancy. Basic Res Cardiol. 2012 Jul; 107(4):271. Li J, Umar S, Iorga A, Youn JY, Wang Y, Regitz-Zagrosek V, Cai H, Eghbali M. PMID: 22648276; PMCID: PMC3769136.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    43. Endothelium-specific sepiapterin reductase deficiency in DOCA-salt hypertension. Am J Physiol Heart Circ Physiol. 2012 Jun 01; 302(11):H2243-9. Youn JY, Wang T, Blair J, Laude KM, Oak JH, McCann LA, Harrison DG, Cai H. PMID: 22467312; PMCID: PMC3378300.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    44. Role of uncoupled endothelial nitric oxide synthase in abdominal aortic aneurysm formation: treatment with folic acid. Hypertension. 2012 Jan; 59(1):158-66. Gao L, Siu KL, Chalupsky K, Nguyen A, Chen P, Weintraub NL, Galis Z, Cai H. PMID: 22083158; PMCID: PMC3668799.
      View in: PubMed   Mentions: 54     Fields:    Translation:Animals
    45. Netrin-1 prevents ischemia/reperfusion-induced myocardial infarction via a DCC/ERK1/2/eNOS s1177/NO/DCC feed-forward mechanism. J Mol Cell Cardiol. 2010 Jun; 48(6):1060-70. Zhang J, Cai H. PMID: 20004665; PMCID: PMC2866819.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    46. Aminoguanidine inhibits aortic hydrogen peroxide production, VSMC NOX activity and hypercontractility in diabetic mice. Cardiovasc Diabetol. 2009 Dec 30; 8:65. Oak JH, Youn JY, Cai H. PMID: 20040119; PMCID: PMC2811700.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    47. Mechanistic insights into folic acid-dependent vascular protection: dihydrofolate reductase (DHFR)-mediated reduction in oxidant stress in endothelial cells and angiotensin II-infused mice: a novel HPLC-based fluorescent assay for DHFR activity. J Mol Cell Cardiol. 2009 Dec; 47(6):752-60. Gao L, Chalupsky K, Stefani E, Cai H. PMID: 19660467; PMCID: PMC2784291.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    48. Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells. J Clin Invest. 2009 Jun; 119(6):1678-87. Lu G, Sun H, She P, Youn JY, Warburton S, Ping P, Vondriska TM, Cai H, Lynch CJ, Wang Y. PMID: 19411760; PMCID: PMC2689111.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    49. Sepiapterin reductase regulation of endothelial tetrahydrobiopterin and nitric oxide bioavailability. Am J Physiol Heart Circ Physiol. 2009 Jul; 297(1):H331-9. Gao L, Pung YF, Zhang J, Chen P, Wang T, Li M, Meza M, Toro L, Cai H. PMID: 19429835; PMCID: PMC2711718.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    50. An ezrin/calpain/PI3K/AMPK/eNOSs1179 signaling cascade mediating VEGF-dependent endothelial nitric oxide production. Circ Res. 2009 Jan 02; 104(1):50-9. Youn JY, Wang T, Cai H. PMID: 19038867; PMCID: PMC2720268.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    51. Mitochondrial pathophysiology, reactive oxygen species, and cardiovascular diseases. Vet Clin North Am Small Anim Pract. 2008 Jan; 38(1):137-55, vi. Gao L, Laude K, Cai H. PMID: 18249246; PMCID: PMC2700041.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    52. CaM Kinase II-dependent pathophysiological signalling in endothelial cells. Cardiovasc Res. 2008 Jan; 77(1):30-4. Cai H, Liu D, Garcia JG. PMID: 18006482.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    53. Attenuation of angiotensin II signaling recouples eNOS and inhibits nonendothelial NOX activity in diabetic mice. Diabetes. 2007 Jan; 56(1):118-26. Oak JH, Cai H. PMID: 17192473.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    54. Detection of reactive oxygen species and nitric oxide in vascular cells and tissues: comparison of sensitivity and specificity. Methods Mol Med. 2007; 139:293-311. Cai H, Dikalov S, Griendling KK, Harrison DG. PMID: 18287681.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
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