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Middlekauff, Holly R

Title(s)Professor, Medicine
SchoolCardiology
Phone3102066672
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    Other Positions
    Title(s)Professor, Physiology


    Collapse Research 
    Collapse Research Activities and Funding
    Sympathetic Nerve Activity and the Skeletal Myopathy of Heart Failure
    NIH/NHLBI R01HL084525Jan 15, 2007 - Jun 30, 2012
    Role: Principal Investigator
    Acupuncture in Cardiovascular Disease
    NIH/NCCIH R21AT000671Jul 15, 2001 - Jun 30, 2004
    Role: Principal Investigator
    Muscle Mechanosensitivity in Heart Failure
    NIH/NHLBI R01HL067298Jul 1, 2001 - Jun 30, 2007
    Role: Principal Investigator
    RENAL BLOOD FLOW DURING EXERCISE IN HEART FAILURE
    NIH/NHLBI R29HL056796Jul 1, 1997 - Jun 30, 2001
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Middlekauff HR. Cardiovascular effects of electronic cigarettes. Nat Rev Cardiol. 2020 Mar 30. PMID: 32231329.
      View in: PubMed
    2. Garcia PD, Gornbein JA, Middlekauff HR. Cardiovascular autonomic effects of electronic cigarette use: a systematic review. Clin Auton Res. 2020 Mar 26. PMID: 32219640.
      View in: PubMed
    3. Ip M, Diamantakos E, Haptonstall K, Choroomi Y, Moheimani RS, Nguyen KH, Tran E, Gornbein J, Middlekauff HR. Tobacco and Electronic Cigarettes Adversely Impact ECG Indices of Ventricular Repolarization: Implication for Sudden Death Risk. Am J Physiol Heart Circ Physiol. 2020 Mar 20. PMID: 32196360.
      View in: PubMed
    4. MacDonald A, Middlekauff HR. Electronic cigarettes and cardiovascular health: what do we know so far? Vasc Health Risk Manag. 2019; 15:159-174. PMID: 31417268.
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    5. Middlekauff HR. Cardiovascular impact of electronic-cigarette use. Trends Cardiovasc Med. 2020 Apr; 30(3):133-140. PMID: 31072697.
      View in: PubMed
    6. Middlekauff HR, Gornbein J. Association of Electronic Cigarette Use With Myocardial Infarction: Persistent Uncertainty. Am J Prev Med. 2019 01; 56(1):159-160. PMID: 30447955.
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    7. Park SH, Fonkoue IT, Li Y, DaCosta DR, Middlekauff HR, Park J. Augmented Cardiopulmonary Baroreflex Sensitivity in Intradialytic Hypertension. Kidney Int Rep. 2018 Nov; 3(6):1394-1402. PMID: 30450466.
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    8. Ip M, Middlekauff HR. Noncigarette Tobacco Products-Gateway or Diversion? JAMA Pediatr. 2018 08 01; 172(8):784. PMID: 29868766.
      View in: PubMed
    9. Middlekauff HR, Araujo JA. Increased Cardiovascular Risk Associated With E-Cigarette Use-Reply. JAMA Cardiol. 2017 10 01; 2(10):1166-1167. PMID: 28593271.
      View in: PubMed
    10. Moheimani RS, Bhetraratana M, Peters KM, Yang BK, Yin F, Gornbein J, Araujo JA, Middlekauff HR. Sympathomimetic Effects of Acute E-Cigarette Use: Role of Nicotine and Non-Nicotine Constituents. J Am Heart Assoc. 2017 Sep 20; 6(9). PMID: 28931527.
      View in: PubMed
    11. Boas Z, Gupta P, Moheimani RS, Bhetraratana M, Yin F, Peters KM, Gornbein J, Araujo JA, Czernin J, Middlekauff HR. Activation of the "Splenocardiac Axis" by electronic and tobacco cigarettes in otherwise healthy young adults. Physiol Rep. 2017 Sep; 5(17). PMID: 28899908.
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    12. Moheimani RS, Bhetraratana M, Yin F, Peters KM, Gornbein J, Araujo JA, Middlekauff HR. Increased Cardiac Sympathetic Activity and Oxidative Stress in Habitual Electronic Cigarette Users: Implications for Cardiovascular Risk. JAMA Cardiol. 2017 03 01; 2(3):278-284. PMID: 28146259.
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    13. Chen JJ, Wu PT, Middlekauff HR, Nguyen KL. Aerobic exercise in anthracycline-induced cardiotoxicity: a systematic review of current evidence and future directions. Am J Physiol Heart Circ Physiol. 2017 Feb 01; 312(2):H213-H222. PMID: 27923793.
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    14. Lobo DM, Trevizan PF, Toschi-Dias E, Oliveira PA, Piveta RB, Almeida DR, Mady C, Bocchi EA, Lorenzi-Filho G, Middlekauff HR, Negrão CE. Sleep-Disordered Breathing Exacerbates Muscle Vasoconstriction and Sympathetic Neural Activation in Patients with Systolic Heart Failure. Circ Heart Fail. 2016 11; 9(11). PMID: 28029639.
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    15. Loewenstein DK, Middlekauff HR. Electronic Cigarette Device-Related Hazards:: A Call for Immediate FDA Regulation. Am J Prev Med. 2017 02; 52(2):229-231. PMID: 27720343.
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    16. Nobre TS, Antunes-Correa LM, Groehs RV, Alves MJ, Sarmento AO, Bacurau AV, Urias U, Alves GB, Rondon MU, Brum PC, Martinelli M, Middlekauff HR, Negrao CE. Exercise training improves neurovascular control and calcium cycling gene expression in patients with heart failure with cardiac resynchronization therapy. Am J Physiol Heart Circ Physiol. 2016 11 01; 311(5):H1180-H1188. PMID: 27591218.
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    17. Macey PM, Rieken NS, Kumar R, Ogren JA, Middlekauff HR, Wu P, Woo MA, Harper RM. Sex Differences in Insular Cortex Gyri Responses to the Valsalva Maneuver. Front Neurol. 2016; 7:87. PMID: 27375549.
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    18. Middlekauff HR. COUNTERPOINT: Does the Risk of Electronic Cigarettes Exceed Potential Benefits? No. Chest. 2015 Sep; 148(3):582-584. PMID: 25837266.
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    19. Middlekauff HR. Rebuttal From Dr Middlekauff. Chest. 2015 Sep; 148(3):585-586. PMID: 25837381.
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    20. Santos MR, Sayegh AL, Groehs RV, Fonseca G, Trombetta IC, Barretto AC, Arap MA, Negrão CE, Middlekauff HR, Alves MJ. Testosterone deficiency increases hospital readmission and mortality rates in male patients with heart failure. Arq Bras Cardiol. 2015 Sep; 105(3):256-64. PMID: 26200897.
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    21. Middlekauff HR. A mechanistic explanation for the minimal impact of renal denervation on 24-h ambulatory blood pressure in SIMPLICITY HTN-3. J Am Coll Cardiol. 2015 Mar 10; 65(9):959. PMID: 25744017.
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    22. Groehs RV, Toschi-Dias E, Antunes-Correa LM, Trevizan PF, Rondon MU, Oliveira P, Alves MJ, Almeida DR, Middlekauff HR, Negrão CE. Exercise training prevents the deterioration in the arterial baroreflex control of sympathetic nerve activity in chronic heart failure patients. Am J Physiol Heart Circ Physiol. 2015 May 01; 308(9):H1096-102. PMID: 25747752.
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    23. Negrao CE, Middlekauff HR, Gomes-Santos IL, Antunes-Correa LM. Effects of exercise training on neurovascular control and skeletal myopathy in systolic heart failure. Am J Physiol Heart Circ Physiol. 2015 Apr 15; 308(8):H792-802. PMID: 25681428.
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    24. Ramanathan G, Araujo JA, Gornbein J, Yin F, Middlekauff HR. Cigarette smoking is associated with dose-dependent adverse effects on paraoxonase activity and fibrinogen in young women. Inhal Toxicol. 2014 Dec; 26(14):861-5. PMID: 25472476.
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    25. Park J, Middlekauff HR. Abnormal neurocirculatory control during exercise in humans with chronic renal failure. Auton Neurosci. 2015 Mar; 188:74-81. PMID: 25458430.
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    26. Middlekauff HR, Park J, Moheimani RS. Adverse effects of cigarette and noncigarette smoke exposure on the autonomic nervous system: mechanisms and implications for cardiovascular risk. J Am Coll Cardiol. 2014 Oct 21; 64(16):1740-50. PMID: 25323263.
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    27. DiFranco M, Quiñonez M, Shieh P, Fonarow GC, Cruz D, Deng MC, Vergara JL, Middlekauff HR. Action potential-evoked calcium release is impaired in single skeletal muscle fibers from heart failure patients. PLoS One. 2014; 9(10):e109309. PMID: 25310188.
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    28. Antunes-Correa LM, Nobre TS, Groehs RV, Alves MJ, Fernandes T, Couto GK, Rondon MU, Oliveira P, Lima M, Mathias W, Brum PC, Mady C, Almeida DR, Rossoni LV, Oliveira EM, Middlekauff HR, Negrao CE. Molecular basis for the improvement in muscle metaboreflex and mechanoreflex control in exercise-trained humans with chronic heart failure. Am J Physiol Heart Circ Physiol. 2014 Dec 01; 307(11):H1655-66. PMID: 25305179.
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    29. Middlekauff HR, Park J, Agrawal H, Gornbein JA. Abnormal sympathetic nerve activity in women exposed to cigarette smoke: a potential mechanism to explain increased cardiac risk. Am J Physiol Heart Circ Physiol. 2013 Nov 15; 305(10):H1560-7. PMID: 23997107.
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    30. Middlekauff HR, Verity MA, Horwich TB, Fonarow GC, Hamilton MA, Shieh P. Intact skeletal muscle mitochondrial enzyme activity but diminished exercise capacity in advanced heart failure patients on optimal medical and device therapy. Clin Res Cardiol. 2013 Aug; 102(8):547-54. PMID: 23575739.
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    31. Park J, Quyyumi AA, Middlekauff HR. Exercise pressor response and arterial baroreflex unloading during exercise in chronic kidney disease. J Appl Physiol (1985). 2013 Mar 01; 114(5):538-49. PMID: 23239869.
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    32. Middlekauff HR, Vigna C, Verity MA, Fonarow GC, Horwich TB, Hamilton MA, Shieh P, Tupling AR. Abnormalities of calcium handling proteins in skeletal muscle mirror those of the heart in humans with heart failure: a shared mechanism? J Card Fail. 2012 Sep; 18(9):724-33. PMID: 22939042.
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    33. Park J, Middlekauff HR, Campese VM. Abnormal sympathetic reactivity to the cold pressor test in overweight humans. Am J Hypertens. 2012 Dec; 25(12):1236-41. PMID: 22895452.
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    34. Nazaré Nunes Alves MJ, Alves MJ, dos Santos MR, Nobre TS, Martinez DG, Martinez DG, Pereira Barretto AC, Brum PC, Rondon MU, Middlekauff HR, Negrão CE. Mechanisms of blunted muscle vasodilation during peripheral chemoreceptor stimulation in heart failure patients. Hypertension. 2012 Sep; 60(3):669-76. PMID: 22802226.
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    35. Middlekauff HR, Park J, Gornbein JA. Lack of effect of ovarian cycle and oral contraceptives on baroreceptor and nonbaroreceptor control of sympathetic nerve activity in healthy women. Am J Physiol Heart Circ Physiol. 2012 Jun 15; 302(12):H2560-6. PMID: 22542619.
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    36. Martinez DG, Nicolau JC, Lage RL, Toschi-Dias E, de Matos LD, Alves MJ, Trombetta IC, Dias da Silva VJ, Middlekauff HR, Negrão CE, Rondon MU. Effects of long-term exercise training on autonomic control in myocardial infarction patients. Hypertension. 2011 Dec; 58(6):1049-56. PMID: 22025377.
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    37. Horwich TB, Middlekauff HR, Maclellan WR, Fonarow GC. Statins do not significantly affect muscle sympathetic nerve activity in humans with nonischemic heart failure: a double-blind placebo-controlled trial. J Card Fail. 2011 Nov; 17(11):879-86. PMID: 22041323.
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    38. Antunes-Correa LM, Kanamura BY, Melo RC, Nobre TS, Ueno LM, Franco FG, Roveda F, Braga AM, Rondon MU, Brum PC, Barretto AC, Middlekauff HR, Negrao CE. Exercise training improves neurovascular control and functional capacity in heart failure patients regardless of age. Eur J Prev Cardiol. 2012 Aug; 19(4):822-9. PMID: 21697210.
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    39. Soares-Miranda L, Franco FG, Roveda F, Martinez DG, Rondon MU, Mota J, Brum PC, Antunes-Correa LM, Nobre TS, Barretto AC, Middlekauff HR, Negrao CE. Effects of exercise training on neurovascular responses during handgrip exercise in heart failure patients. Int J Cardiol. 2011 Jan 07; 146(1):122-5. PMID: 20970205.
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    40. Middlekauff HR. Making the case for skeletal myopathy as the major limitation of exercise capacity in heart failure. Circ Heart Fail. 2010 Jul; 3(4):537-46. PMID: 20647489.
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    41. Antunes-Correa LM, Melo RC, Nobre TS, Ueno LM, Franco FG, Braga AM, Rondon MU, Brum PC, Barretto AC, Middlekauff HR, Negrao CE. Impact of gender on benefits of exercise training on sympathetic nerve activity and muscle blood flow in heart failure. Eur J Heart Fail. 2010 Jan; 12(1):58-65. PMID: 20023046.
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    42. Park J, Middlekauff HR. Altered pattern of sympathetic activity with the ovarian cycle in female smokers. Am J Physiol Heart Circ Physiol. 2009 Aug; 297(2):H564-8. PMID: 19525371.
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    43. Ueno LM, Drager LF, Rodrigues AC, Rondon MU, Braga AM, Mathias W, Krieger EM, Barretto AC, Middlekauff HR, Lorenzi-Filho G, Negrão CE. Effects of exercise training in patients with chronic heart failure and sleep apnea. Sleep. 2009 May; 32(5):637-47. PMID: 19480231.
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    44. Park J, Campese VM, Nobakht N, Middlekauff HR. Differential distribution of muscle and skin sympathetic nerve activity in patients with end-stage renal disease. J Appl Physiol (1985). 2008 Dec; 105(6):1873-6. PMID: 18845779.
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    45. Negrão CE, Santos AC, Rondon MU, Franco FG, Ianni B, Rochitte CE, Braga AM, Oliveira MT, Mady C, Barretto AC, Middlekauff HR. Muscle sympathetic nerve activity in patients with Chagas' disease. Int J Cardiol. 2009 Nov 12; 137(3):252-9. PMID: 18723231.
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    46. Park J, Campese VM, Middlekauff HR. Exercise pressor reflex in humans with end-stage renal disease. Am J Physiol Regul Integr Comp Physiol. 2008 Oct; 295(4):R1188-94. PMID: 18685067.
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    47. Barretto AC, Santos AC, Munhoz R, Rondon MU, Franco FG, Trombetta IC, Roveda F, de Matos LN, Braga AM, Middlekauff HR, Negrão CE. Increased muscle sympathetic nerve activity predicts mortality in heart failure patients. Int J Cardiol. 2009 Jul 10; 135(3):302-7. PMID: 18582965.
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    48. Horwich TB, Middlekauff HR. Potential autonomic nervous system effects of statins in heart failure. Heart Fail Clin. 2008 Apr; 4(2):163-70. PMID: 18433696.
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    49. Middlekauff HR, Chiu J, Hamilton MA, Fonarow GC, Maclellan WR, Hage A, Moriguchi J, Patel J. Cyclooxygenase products sensitize muscle mechanoreceptors in humans with heart failure. Am J Physiol Heart Circ Physiol. 2008 Apr; 294(4):H1956-62. PMID: 18296564.
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    50. Negrao CE, Middlekauff HR. Adaptations in autonomic function during exercise training in heart failure. Heart Fail Rev. 2008 Feb; 13(1):51-60. PMID: 17932745.
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    51. Negrão CE, Middlekauff HR. Exercise training in heart failure: reduction in angiotensin II, sympathetic nerve activity, and baroreflex control. J Appl Physiol (1985). 2008 Mar; 104(3):577-8. PMID: 18174387.
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    52. Alves MJ, Rondon MU, Santos AC, Dias RG, Barretto AC, Krieger EM, Middlekauff HR, Negrão CE. Sympathetic nerve activity restrains reflex vasodilatation in heart failure. Clin Auton Res. 2007 Dec; 17(6):364-9. PMID: 18043866.
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    53. Fraga R, Franco FG, Roveda F, de Matos LN, Braga AM, Rondon MU, Rotta DR, Brum PC, Barretto AC, Middlekauff HR, Negrão CE. Exercise training reduces sympathetic nerve activity in heart failure patients treated with carvedilol. Eur J Heart Fail. 2007 Jun-Jul; 9(6-7):630-6. PMID: 17475552.
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    54. Di Vanna A, Braga AM, Laterza MC, Ueno LM, Rondon MU, Barretto AC, Middlekauff HR, Negrão CE. Blunted muscle vasodilatation during chemoreceptor stimulation in patients with heart failure. Am J Physiol Heart Circ Physiol. 2007 Jul; 293(1):H846-52. PMID: 17434973.
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    55. Middlekauff HR, Sinoway LI. Increased mechanoreceptor stimulation explains the exaggerated exercise pressor reflex seen in heart failure. J Appl Physiol (1985). 2007 Jan; 102(1):492-4; discussion 496. PMID: 16990501.
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    56. Rondon E, Brasileiro-Santos MS, Moreira ED, Rondon MU, Mattos KC, Coelho MA, Silva GJ, Brum PC, Fiorino P, Irigoyen MC, Krieger EM, Middlekauff HR, Negrão CE. Exercise training improves aortic depressor nerve sensitivity in rats with ischemia-induced heart failure. Am J Physiol Heart Circ Physiol. 2006 Dec; 291(6):H2801-6. PMID: 16798817.
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    57. de Mello Franco FG, Santos AC, Rondon MU, Trombetta IC, Strunz C, Braga AM, Middlekauff H, Negrão CE, Pereira Barretto AC. Effects of home-based exercise training on neurovascular control in patients with heart failure. Eur J Heart Fail. 2006 Dec; 8(8):851-5. PMID: 16714146.
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    58. Middlekauff HR. How does cardiac resynchronization therapy improve exercise capacity in chronic heart failure? J Card Fail. 2005 Sep; 11(7):534-41. PMID: 16198250.
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    59. Santos AC, Alves MJ, Rondon MU, Barretto AC, Middlekauff HR, Negrão CE. Sympathetic activation restrains endothelium-mediated muscle vasodilatation in heart failure patients. Am J Physiol Heart Circ Physiol. 2005 Aug; 289(2):H593-9. PMID: 15778282.
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    60. Thomas MA, Chung HK, Middlekauff H. Localized two-dimensional 1H magnetic resonance exchange spectroscopy: a preliminary evaluation in human muscle. Magn Reson Med. 2005 Mar; 53(3):495-502. PMID: 15723396.
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    61. De Matos LD, Gardenghi G, Rondon MU, Soufen HN, Tirone AP, Barretto AC, Brum PC, Middlekauff HR, Negrão CE. Impact of 6 months of therapy with carvedilol on muscle sympathetic nerve activity in heart failure patients. J Card Fail. 2004 Dec; 10(6):496-502. PMID: 15599840.
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    62. Middlekauff HR, Chiu J, Hamilton MA, Fonarow GC, Maclellan WR, Hage A, Moriguchi J, Patel J. Muscle mechanoreceptor sensitivity in heart failure. Am J Physiol Heart Circ Physiol. 2004 Nov; 287(5):H1937-43. PMID: 15475527.
      View in: PubMed
    63. Middlekauff HR, Chiu J. Cyclooxygenase products sensitize muscle mechanoreceptors in healthy humans. Am J Physiol Heart Circ Physiol. 2004 Nov; 287(5):H1944-9. PMID: 15475528.
      View in: PubMed
    64. Middlekauff HR. Acupuncture in the treatment of heart failure. Cardiol Rev. 2004 May-Jun; 12(3):171-3. PMID: 15078586.
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    65. Middlekauff HR, Shah JB, Yu JL, Hui K. Acupuncture effects on autonomic responses to cold pressor and handgrip exercise in healthy humans. Clin Auton Res. 2004 Apr; 14(2):113-8. PMID: 15095054.
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    66. Roveda F, Middlekauff HR, Rondon MU, Reis SF, Souza M, Nastari L, Barretto AC, Krieger EM, Negrão CE. The effects of exercise training on sympathetic neural activation in advanced heart failure: a randomized controlled trial. J Am Coll Cardiol. 2003 Sep 03; 42(5):854-60. PMID: 12957432.
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    67. Middlekauff HR, Hui K, Yu JL, Hamilton MA, Fonarow GC, Moriguchi J, Maclellan WR, Hage A. Acupuncture inhibits sympathetic activation during mental stress in advanced heart failure patients. J Card Fail. 2002 Dec; 8(6):399-406. PMID: 12528093.
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    68. Middlekauff HR, Yu JL, Hui K. Acupuncture effects on reflex responses to mental stress in humans. Am J Physiol Regul Integr Comp Physiol. 2001 May; 280(5):R1462-8. PMID: 11294769.
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    69. Middlekauff HR, Nitzsche EU, Hoh CK, Hamilton MA, Fonarow GC, Hage A, Moriguchi JD. Exaggerated muscle mechanoreflex control of reflex renal vasoconstriction in heart failure. J Appl Physiol (1985). 2001 May; 90(5):1714-9. PMID: 11299260.
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