Holly R Middlekauff

Title(s)Professor, Medicine
SchoolMedicine
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    Other Positions
    Title(s)Professor, Physiology


    Collapse Research 
    Collapse Research Activities and Funding
    Sympathetic Nerve Activity and the Skeletal Myopathy of Heart Failure
    NIH R01HL084525Jan 15, 2007 - Jun 30, 2012
    Role: Principal Investigator
    Acupuncture in Cardiovascular Disease
    NIH R21AT000671Jul 15, 2001 - Jun 30, 2004
    Role: Principal Investigator
    Muscle Mechanosensitivity in Heart Failure
    NIH R01HL067298Jul 1, 2001 - Jun 30, 2007
    Role: Principal Investigator
    RENAL BLOOD FLOW DURING EXERCISE IN HEART FAILURE
    NIH R29HL056796Jul 1, 1997 - Jun 30, 2001
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Optimizing ECG lead selection for detection of prolongation of ventricular repolarization as measured by the Tpeak-end interval. Ann Noninvasive Electrocardiol. 2022 Jun 16; e12958. Ruedisueli I, Ma J, Nguyen R, Lakhani K, Gornbein J, Middlekauff HR. PMID: 35712805.
      View in: PubMed   Mentions:
    2. Drugs of Misuse: Focus on Vascular Dysfunction. Can J Cardiol. 2022 Apr 21. Middlekauff HR, Cooper ZD, Strauss SB. PMID: 35462024.
      View in: PubMed   Mentions:
    3. Instigators of COVID-19 in Immune Cells Are Increased in Tobacco Cigarette Smokers and Electronic Cigarette Vapers Compared With Nonsmokers. Nicotine Tob Res. 2022 02 14; 24(3):413-415. Kelesidis T, Zhang Y, Tran E, Sosa G, Middlekauff HR. PMID: 34410424; PMCID: PMC8513409.
      View in: PubMed   Mentions:    Fields:    
    4. Association of 1 Vaping Session With Cellular Oxidative Stress in Otherwise Healthy Young People With No History of Smoking or Vaping: A Randomized Clinical Crossover Trial. JAMA Pediatr. 2021 11 01; 175(11):1174-1176. Kelesidis T, Tran E, Nguyen R, Zhang Y, Sosa G, Middlekauff HR. PMID: 34369981; PMCID: PMC8353577.
      View in: PubMed   Mentions:    Fields:    
    5. Electronic and Tobacco Cigarettes Alter Polyunsaturated Fatty Acids and Oxidative Biomarkers. Circ Res. 2021 08 20; 129(5):514-526. Gupta R, Lin Y, Luna K, Logue A, Yoon AJ, Haptonstall KP, Moheimani R, Choroomi Y, Nguyen K, Tran E, Zhu Y, Faull KF, Kelesidis T, Gornbein J, Middlekauff HR, Araujo JA. PMID: 34187173; PMCID: PMC8376792.
      View in: PubMed   Mentions:    Fields:    
    6. Increased Expression of Proatherogenic Proteins in Immune Cell Subtypes in Tobacco Cigarette Smokers But Not in Electronic Cigarette Vapers. Can J Cardiol. 2021 08; 37(8):1175-1180. Kelesidis T, Zhang Y, Tran E, Sosa G, Middlekauff HR. PMID: 34023441; PMCID: PMC9014478.
      View in: PubMed   Mentions:    Fields:    
    7. Vaping and cardiac disease. Heart. 2021 10; 107(19):1530-1535. Shahandeh N, Chowdhary H, Middlekauff HR. PMID: 33574049.
      View in: PubMed   Mentions: 1     Fields:    
    8. Expression of Key Inflammatory Proteins Is Increased in Immune Cells From Tobacco Cigarette Smokers But Not Electronic Cigarette Vapers: Implications for Atherosclerosis. J Am Heart Assoc. 2021 01 05; 10(1):e019324. Kelesidis T, Zhang Y, Tran E, Sosa G, Middlekauff HR. PMID: 33356378; PMCID: PMC7955503.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    9. Vaping Instead of Cigarette Smoking: A Panacea or Just Another Form of Cardiovascular Risk? Can J Cardiol. 2021 05; 37(5):690-698. Nayeri A, Middlekauff H. PMID: 33338608.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Changes in lipid composition associated with electronic cigarette use. J Transl Med. 2020 10 07; 18(1):379. Middlekauff HR, William KJ, Su B, Haptonstall K, Araujo JA, Wu X, Kim J, Sallam T. PMID: 33028369; PMCID: PMC7542424.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Elevated Cellular Oxidative Stress in Circulating Immune Cells in Otherwise Healthy Young People Who Use Electronic Cigarettes in a Cross-Sectional Single-Center Study: Implications for Future Cardiovascular Risk. J Am Heart Assoc. 2020 09 15; 9(18):e016983. Kelesidis T, Tran E, Arastoo S, Lakhani K, Heymans R, Gornbein J, Middlekauff HR. PMID: 32896211; PMCID: PMC7726977.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    12. Differential effects of tobacco cigarettes and electronic cigarettes on endothelial function in healthy young people. Am J Physiol Heart Circ Physiol. 2020 09 01; 319(3):H547-H556. Haptonstall KP, Choroomi Y, Moheimani R, Nguyen K, Tran E, Lakhani K, Ruedisueli I, Gornbein J, Middlekauff HR. PMID: 32734819; PMCID: PMC7509270.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    13. Cardiovascular effects of electronic cigarettes. Nat Rev Cardiol. 2020 07; 17(7):379-381. Middlekauff HR. PMID: 32231329.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    14. Acute and chronic sympathomimetic effects of e-cigarette and tobacco cigarette smoking: role of nicotine and non-nicotine constituents. Am J Physiol Heart Circ Physiol. 2020 08 01; 319(2):H262-H270. Arastoo S, Haptonstall KP, Choroomi Y, Moheimani R, Nguyen K, Tran E, Gornbein J, Middlekauff HR. PMID: 32559135; PMCID: PMC7473924.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansPHPublic Health
    15. A Case of Ventricular Tachycardia Caused by a Rare Cardiac Mesenchymal Hamartoma. JACC Case Rep. 2020 Jun 17; 2(7):1049-1055. Feng Z, Philipson D, Uzzell JP, Stein-Merlob A, Yang EH, Middlekauff HR, Lau RP, Fishbein GA, Bradfield JS, Ajijola OA. PMID: 34317413; PMCID: PMC8302110.
      View in: PubMed   Mentions:
    16. Acquired Long QT Syndrome after Acute Myocardial Infarction: A Rare but Potentially Fatal Entity. Tex Heart Inst J. 2020 04 01; 47(2):163-164. Gordon SS, Hollowed J, Hayase J, Macias C, Wang J, Middlekauff HR. PMID: 32603470; PMCID: PMC7328093.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Cardiovascular autonomic effects of electronic cigarette use: a systematic review. Clin Auton Res. 2020 12; 30(6):507-519. Garcia PD, Gornbein JA, Middlekauff HR. PMID: 32219640; PMCID: PMC7704447.
      View in: PubMed   Mentions: 7     Fields:    
    18. Tobacco and electronic cigarettes adversely impact ECG indexes of ventricular repolarization: implication for sudden death risk. Am J Physiol Heart Circ Physiol. 2020 05 01; 318(5):H1176-H1184. Ip M, Diamantakos E, Haptonstall K, Choroomi Y, Moheimani RS, Nguyen KH, Tran E, Gornbein J, Middlekauff HR. PMID: 32196360; PMCID: PMC7346537.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    19. Electronic cigarettes and cardiovascular health: what do we know so far? Vasc Health Risk Manag. 2019; 15:159-174. MacDonald A, Middlekauff HR. PMID: 31417268; PMCID: PMC6592370.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    20. Cardiovascular impact of electronic-cigarette use. Trends Cardiovasc Med. 2020 04; 30(3):133-140. Middlekauff HR. PMID: 31072697.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    21. Association of Electronic Cigarette Use With Myocardial Infarction: Persistent Uncertainty. Am J Prev Med. 2019 01; 56(1):159-160. Middlekauff HR, Gornbein J. PMID: 30447955.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    22. Augmented Cardiopulmonary Baroreflex Sensitivity in Intradialytic Hypertension. Kidney Int Rep. 2018 Nov; 3(6):1394-1402. Park SH, Fonkoue IT, Li Y, DaCosta DR, Middlekauff HR, Park J. PMID: 30450466; PMCID: PMC6224617.
      View in: PubMed   Mentions: 2  
    23. Noncigarette Tobacco Products-Gateway or Diversion? JAMA Pediatr. 2018 08 01; 172(8):784. Ip M, Middlekauff HR. PMID: 29868766.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    24. Increased Cardiovascular Risk Associated With E-Cigarette Use-Reply. JAMA Cardiol. 2017 10 01; 2(10):1166-1167. Middlekauff HR, Araujo JA. PMID: 28593271.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. Sympathomimetic Effects of Acute E-Cigarette Use: Role of Nicotine and Non-Nicotine Constituents. J Am Heart Assoc. 2017 Sep 20; 6(9). Moheimani RS, Bhetraratana M, Peters KM, Yang BK, Yin F, Gornbein J, Araujo JA, Middlekauff HR. PMID: 28931527; PMCID: PMC5634299.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    26. Activation of the "Splenocardiac Axis" by electronic and tobacco cigarettes in otherwise healthy young adults. Physiol Rep. 2017 Sep; 5(17). Boas Z, Gupta P, Moheimani RS, Bhetraratana M, Yin F, Peters KM, Gornbein J, Araujo JA, Czernin J, Middlekauff HR. PMID: 28899908; PMCID: PMC5599858.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    27. Increased Cardiac Sympathetic Activity and Oxidative Stress in Habitual Electronic Cigarette Users: Implications for Cardiovascular Risk. JAMA Cardiol. 2017 03 01; 2(3):278-284. Moheimani RS, Bhetraratana M, Yin F, Peters KM, Gornbein J, Araujo JA, Middlekauff HR. PMID: 28146259; PMCID: PMC5626008.
      View in: PubMed   Mentions: 70     Fields:    Translation:Humans
    28. Aerobic exercise in anthracycline-induced cardiotoxicity: a systematic review of current evidence and future directions. Am J Physiol Heart Circ Physiol. 2017 Feb 01; 312(2):H213-H222. Chen JJ, Wu PT, Middlekauff HR, Nguyen KL. PMID: 27923793; PMCID: PMC6734062.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    29. Sleep-Disordered Breathing Exacerbates Muscle Vasoconstriction and Sympathetic Neural Activation in Patients with Systolic Heart Failure. Circ Heart Fail. 2016 11; 9(11). Lobo DM, Trevizan PF, Toschi-Dias E, Oliveira PA, Piveta RB, Almeida DR, Mady C, Bocchi EA, Lorenzi-Filho G, Middlekauff HR, Negrão CE. PMID: 28029639.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    30. Electronic Cigarette Device-Related Hazards:: A Call for Immediate FDA Regulation. Am J Prev Med. 2017 02; 52(2):229-231. Loewenstein DK, Middlekauff HR. PMID: 27720343; PMCID: PMC6718197.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    31. Exercise training improves neurovascular control and calcium cycling gene expression in patients with heart failure with cardiac resynchronization therapy. Am J Physiol Heart Circ Physiol. 2016 11 01; 311(5):H1180-H1188. Nobre TS, Antunes-Correa LM, Groehs RV, Alves MJ, Sarmento AO, Bacurau AV, Urias U, Alves GB, Rondon MU, Brum PC, Martinelli M, Middlekauff HR, Negrao CE. PMID: 27591218; PMCID: PMC6347073.
      View in: PubMed   Mentions: 6  Translation:Humans
    32. Sex Differences in Insular Cortex Gyri Responses to the Valsalva Maneuver. Front Neurol. 2016; 7:87. Macey PM, Rieken NS, Kumar R, Ogren JA, Middlekauff HR, Wu P, Woo MA, Harper RM. PMID: 27375549; PMCID: PMC4899449.
      View in: PubMed   Mentions: 12  
    33. Rebuttal From Dr Middlekauff. Chest. 2015 Sep; 148(3):585-586. Middlekauff HR. PMID: 25837381.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    34. COUNTERPOINT: Does the Risk of Electronic Cigarettes Exceed Potential Benefits? No. Chest. 2015 Sep; 148(3):582-584. Middlekauff HR. PMID: 25837266.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    35. Testosterone deficiency increases hospital readmission and mortality rates in male patients with heart failure. Arq Bras Cardiol. 2015 Sep; 105(3):256-64. Santos MR, Sayegh AL, Groehs RV, Fonseca G, Trombetta IC, Barretto AC, Arap MA, Negrão CE, Middlekauff HR, Alves MJ. PMID: 26200897; PMCID: PMC4592174.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    36. A mechanistic explanation for the minimal impact of renal denervation on 24-h ambulatory blood pressure in SIMPLICITY HTN-3. J Am Coll Cardiol. 2015 Mar 10; 65(9):959. Middlekauff HR. PMID: 25744017.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    37. Exercise training prevents the deterioration in the arterial baroreflex control of sympathetic nerve activity in chronic heart failure patients. Am J Physiol Heart Circ Physiol. 2015 May 01; 308(9):H1096-102. Groehs RV, Toschi-Dias E, Antunes-Correa LM, Trevizan PF, Rondon MU, Oliveira P, Alves MJ, Almeida DR, Middlekauff HR, Negrão CE. PMID: 25747752; PMCID: PMC4551124.
      View in: PubMed   Mentions: 10  Translation:Humans
    38. Effects of exercise training on neurovascular control and skeletal myopathy in systolic heart failure. Am J Physiol Heart Circ Physiol. 2015 Apr 15; 308(8):H792-802. Negrao CE, Middlekauff HR, Gomes-Santos IL, Antunes-Correa LM. PMID: 25681428; PMCID: PMC4398863.
      View in: PubMed   Mentions: 15  Translation:Humans
    39. Cigarette smoking is associated with dose-dependent adverse effects on paraoxonase activity and fibrinogen in young women. Inhal Toxicol. 2014 Dec; 26(14):861-5. Ramanathan G, Araujo JA, Gornbein J, Yin F, Middlekauff HR. PMID: 25472476; PMCID: PMC4266070.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    40. Abnormal neurocirculatory control during exercise in humans with chronic renal failure. Auton Neurosci. 2015 Mar; 188:74-81. Park J, Middlekauff HR. PMID: 25458430; PMCID: PMC4336567.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    41. Adverse effects of cigarette and noncigarette smoke exposure on the autonomic nervous system: mechanisms and implications for cardiovascular risk. J Am Coll Cardiol. 2014 Oct 21; 64(16):1740-50. Middlekauff HR, Park J, Moheimani RS. PMID: 25323263.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimals
    42. Action potential-evoked calcium release is impaired in single skeletal muscle fibers from heart failure patients. PLoS One. 2014; 9(10):e109309. DiFranco M, Quiñonez M, Shieh P, Fonarow GC, Cruz D, Deng MC, Vergara JL, Middlekauff HR. PMID: 25310188; PMCID: PMC4195605.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    43. Molecular basis for the improvement in muscle metaboreflex and mechanoreflex control in exercise-trained humans with chronic heart failure. Am J Physiol Heart Circ Physiol. 2014 Dec 01; 307(11):H1655-66. Antunes-Correa LM, Nobre TS, Groehs RV, Alves MJ, Fernandes T, Couto GK, Rondon MU, Oliveira P, Lima M, Mathias W, Brum PC, Mady C, Almeida DR, Rossoni LV, Oliveira EM, Middlekauff HR, Negrao CE. PMID: 25305179; PMCID: PMC4255006.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    44. Abnormal sympathetic nerve activity in women exposed to cigarette smoke: a potential mechanism to explain increased cardiac risk. Am J Physiol Heart Circ Physiol. 2013 Nov 15; 305(10):H1560-7. Middlekauff HR, Park J, Agrawal H, Gornbein JA. PMID: 23997107; PMCID: PMC4073979.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansPHPublic Health
    45. Intact skeletal muscle mitochondrial enzyme activity but diminished exercise capacity in advanced heart failure patients on optimal medical and device therapy. Clin Res Cardiol. 2013 Aug; 102(8):547-54. Middlekauff HR, Verity MA, Horwich TB, Fonarow GC, Hamilton MA, Shieh P. PMID: 23575739; PMCID: PMC3710307.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    46. Exercise pressor response and arterial baroreflex unloading during exercise in chronic kidney disease. J Appl Physiol (1985). 2013 Mar 01; 114(5):538-49. Park J, Quyyumi AA, Middlekauff HR. PMID: 23239869; PMCID: PMC3615589.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    47. Abnormalities of calcium handling proteins in skeletal muscle mirror those of the heart in humans with heart failure: a shared mechanism? J Card Fail. 2012 Sep; 18(9):724-33. Middlekauff HR, Vigna C, Verity MA, Fonarow GC, Horwich TB, Hamilton MA, Shieh P, Tupling AR. PMID: 22939042; PMCID: PMC3437990.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    48. Abnormal sympathetic reactivity to the cold pressor test in overweight humans. Am J Hypertens. 2012 Dec; 25(12):1236-41. Park J, Middlekauff HR, Campese VM. PMID: 22895452; PMCID: PMC3577042.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    49. Mechanisms of blunted muscle vasodilation during peripheral chemoreceptor stimulation in heart failure patients. Hypertension. 2012 Sep; 60(3):669-76. Nazaré Nunes Alves MJ, Alves MJ, dos Santos MR, Nobre TS, Martinez DG, Martinez DG, Pereira Barretto AC, Brum PC, Rondon MU, Middlekauff HR, Negrão CE. PMID: 22802226.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    50. Lack of effect of ovarian cycle and oral contraceptives on baroreceptor and nonbaroreceptor control of sympathetic nerve activity in healthy women. Am J Physiol Heart Circ Physiol. 2012 Jun 15; 302(12):H2560-6. Middlekauff HR, Park J, Gornbein JA. PMID: 22542619; PMCID: PMC3378265.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    51. Effects of long-term exercise training on autonomic control in myocardial infarction patients. Hypertension. 2011 Dec; 58(6):1049-56. Martinez DG, Nicolau JC, Lage RL, Toschi-Dias E, de Matos LD, Alves MJ, Trombetta IC, Dias da Silva VJ, Middlekauff HR, Negrão CE, Rondon MU. PMID: 22025377.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    52. Statins do not significantly affect muscle sympathetic nerve activity in humans with nonischemic heart failure: a double-blind placebo-controlled trial. J Card Fail. 2011 Nov; 17(11):879-86. Horwich TB, Middlekauff HR, Maclellan WR, Fonarow GC. PMID: 22041323; PMCID: PMC3206298.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    53. Exercise training improves neurovascular control and functional capacity in heart failure patients regardless of age. Eur J Prev Cardiol. 2012 Aug; 19(4):822-9. Antunes-Correa LM, Kanamura BY, Melo RC, Nobre TS, Ueno LM, Franco FG, Roveda F, Braga AM, Rondon MU, Brum PC, Barretto AC, Middlekauff HR, Negrao CE. PMID: 21697210.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    54. Effects of exercise training on neurovascular responses during handgrip exercise in heart failure patients. Int J Cardiol. 2011 Jan 07; 146(1):122-5. Soares-Miranda L, Franco FG, Roveda F, Martinez DG, Rondon MU, Mota J, Brum PC, Antunes-Correa LM, Nobre TS, Barretto AC, Middlekauff HR, Negrao CE. PMID: 20970205.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    55. Making the case for skeletal myopathy as the major limitation of exercise capacity in heart failure. Circ Heart Fail. 2010 Jul; 3(4):537-46. Middlekauff HR. PMID: 20647489; PMCID: PMC3056569.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimals
    56. Impact of gender on benefits of exercise training on sympathetic nerve activity and muscle blood flow in heart failure. Eur J Heart Fail. 2010 Jan; 12(1):58-65. Antunes-Correa LM, Melo RC, Nobre TS, Ueno LM, Franco FG, Braga AM, Rondon MU, Brum PC, Barretto AC, Middlekauff HR, Negrao CE. PMID: 20023046; PMCID: PMC2796143.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    57. Altered pattern of sympathetic activity with the ovarian cycle in female smokers. Am J Physiol Heart Circ Physiol. 2009 Aug; 297(2):H564-8. Park J, Middlekauff HR. PMID: 19525371; PMCID: PMC2724219.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    58. Effects of exercise training in patients with chronic heart failure and sleep apnea. Sleep. 2009 May; 32(5):637-47. Ueno LM, Drager LF, Rodrigues AC, Rondon MU, Braga AM, Mathias W, Krieger EM, Barretto AC, Middlekauff HR, Lorenzi-Filho G, Negrão CE. PMID: 19480231; PMCID: PMC2675899.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    59. Differential distribution of muscle and skin sympathetic nerve activity in patients with end-stage renal disease. J Appl Physiol (1985). 2008 Dec; 105(6):1873-6. Park J, Campese VM, Nobakht N, Middlekauff HR. PMID: 18845779; PMCID: PMC2612470.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    60. Muscle sympathetic nerve activity in patients with Chagas' disease. Int J Cardiol. 2009 Nov 12; 137(3):252-9. Negrão CE, Santos AC, Rondon MU, Franco FG, Ianni B, Rochitte CE, Braga AM, Oliveira MT, Mady C, Barretto AC, Middlekauff HR. PMID: 18723231.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    61. Exercise pressor reflex in humans with end-stage renal disease. Am J Physiol Regul Integr Comp Physiol. 2008 Oct; 295(4):R1188-94. Park J, Campese VM, Middlekauff HR. PMID: 18685067; PMCID: PMC2576092.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCellsCTClinical Trials
    62. Increased muscle sympathetic nerve activity predicts mortality in heart failure patients. Int J Cardiol. 2009 Jul 10; 135(3):302-7. Barretto AC, Santos AC, Munhoz R, Rondon MU, Franco FG, Trombetta IC, Roveda F, de Matos LN, Braga AM, Middlekauff HR, Negrão CE. PMID: 18582965.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansCells
    63. Potential autonomic nervous system effects of statins in heart failure. Heart Fail Clin. 2008 Apr; 4(2):163-70. Horwich TB, Middlekauff HR. PMID: 18433696; PMCID: PMC2440345.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    64. Cyclooxygenase products sensitize muscle mechanoreceptors in humans with heart failure. Am J Physiol Heart Circ Physiol. 2008 Apr; 294(4):H1956-62. Middlekauff HR, Chiu J, Hamilton MA, Fonarow GC, Maclellan WR, Hage A, Moriguchi J, Patel J. PMID: 18296564.
      View in: PubMed   Mentions: 17  Translation:HumansCells
    65. Adaptations in autonomic function during exercise training in heart failure. Heart Fail Rev. 2008 Feb; 13(1):51-60. Negrao CE, Middlekauff HR. PMID: 17932745.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    66. Exercise training in heart failure: reduction in angiotensin II, sympathetic nerve activity, and baroreflex control. J Appl Physiol (1985). 2008 Mar; 104(3):577-8. Negrão CE, Middlekauff HR. PMID: 18174387.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    67. Sympathetic nerve activity restrains reflex vasodilatation in heart failure. Clin Auton Res. 2007 Dec; 17(6):364-9. Alves MJ, Rondon MU, Santos AC, Dias RG, Barretto AC, Krieger EM, Middlekauff HR, Negrão CE. PMID: 18043866.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    68. Exercise training reduces sympathetic nerve activity in heart failure patients treated with carvedilol. Eur J Heart Fail. 2007 Jun-Jul; 9(6-7):630-6. Fraga R, Franco FG, Roveda F, de Matos LN, Braga AM, Rondon MU, Rotta DR, Brum PC, Barretto AC, Middlekauff HR, Negrão CE. PMID: 17475552.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    69. Blunted muscle vasodilatation during chemoreceptor stimulation in patients with heart failure. Am J Physiol Heart Circ Physiol. 2007 Jul; 293(1):H846-52. Di Vanna A, Braga AM, Laterza MC, Ueno LM, Rondon MU, Barretto AC, Middlekauff HR, Negrão CE. PMID: 17434973.
      View in: PubMed   Mentions: 8  Translation:HumansCells
    70. Increased mechanoreceptor stimulation explains the exaggerated exercise pressor reflex seen in heart failure. J Appl Physiol (1985). 2007 Jan; 102(1):492-4; discussion 496. Middlekauff HR, Sinoway LI. PMID: 16990501.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    71. Exercise training improves aortic depressor nerve sensitivity in rats with ischemia-induced heart failure. Am J Physiol Heart Circ Physiol. 2006 Dec; 291(6):H2801-6. Rondon E, Brasileiro-Santos MS, Moreira ED, Rondon MU, Mattos KC, Coelho MA, Silva GJ, Brum PC, Fiorino P, Irigoyen MC, Krieger EM, Middlekauff HR, Negrão CE. PMID: 16798817.
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    72. Effects of home-based exercise training on neurovascular control in patients with heart failure. Eur J Heart Fail. 2006 Dec; 8(8):851-5. de Mello Franco FG, Santos AC, Rondon MU, Trombetta IC, Strunz C, Braga AM, Middlekauff H, Negrão CE, Pereira Barretto AC. PMID: 16714146.
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    73. The decreased oxygen uptake during progressive exercise in ischemia-induced heart failure is due to reduced cardiac output rate. Braz J Med Biol Res. 2006 Feb; 39(2):297-304. Rolim NP, Mattos KC, Brum PC, Baldo MV, Middlekauff HR, Negrão CE. PMID: 16470319.
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    74. How does cardiac resynchronization therapy improve exercise capacity in chronic heart failure? J Card Fail. 2005 Sep; 11(7):534-41. Middlekauff HR. PMID: 16198250.
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    75. Sympathetic activation restrains endothelium-mediated muscle vasodilatation in heart failure patients. Am J Physiol Heart Circ Physiol. 2005 Aug; 289(2):H593-9. Santos AC, Alves MJ, Rondon MU, Barretto AC, Middlekauff HR, Negrão CE. PMID: 15778282.
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    76. Localized two-dimensional 1H magnetic resonance exchange spectroscopy: a preliminary evaluation in human muscle. Magn Reson Med. 2005 Mar; 53(3):495-502. Thomas MA, Chung HK, Middlekauff H. PMID: 15723396.
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    77. Impact of 6 months of therapy with carvedilol on muscle sympathetic nerve activity in heart failure patients. J Card Fail. 2004 Dec; 10(6):496-502. De Matos LD, Gardenghi G, Rondon MU, Soufen HN, Tirone AP, Barretto AC, Brum PC, Middlekauff HR, Negrão CE. PMID: 15599840.
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    78. Muscle mechanoreceptor sensitivity in heart failure. Am J Physiol Heart Circ Physiol. 2004 Nov; 287(5):H1937-43. Middlekauff HR, Chiu J, Hamilton MA, Fonarow GC, Maclellan WR, Hage A, Moriguchi J, Patel J. PMID: 15475527.
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    79. Cyclooxygenase products sensitize muscle mechanoreceptors in healthy humans. Am J Physiol Heart Circ Physiol. 2004 Nov; 287(5):H1944-9. Middlekauff HR, Chiu J. PMID: 15475528.
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    80. Acupuncture in the treatment of heart failure. Cardiol Rev. 2004 May-Jun; 12(3):171-3. Middlekauff HR. PMID: 15078586.
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    81. Acupuncture effects on autonomic responses to cold pressor and handgrip exercise in healthy humans. Clin Auton Res. 2004 Apr; 14(2):113-8. Middlekauff HR, Shah JB, Yu JL, Hui K. PMID: 15095054.
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    82. Signal-averaged electrocardiogram in Ebstein's anomaly. Am J Cardiol. 2004 Feb 15; 93(4):432-6. Tede NH, Shivkumar K, Perloff JK, Middlekauff HR, Fishbein MC, Child JS, Laks H. PMID: 14969616.
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    83. The effects of exercise training on sympathetic neural activation in advanced heart failure: a randomized controlled trial. J Am Coll Cardiol. 2003 Sep 03; 42(5):854-60. Roveda F, Middlekauff HR, Rondon MU, Reis SF, Souza M, Nastari L, Barretto AC, Krieger EM, Negrão CE. PMID: 12957432.
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    84. Acupuncture inhibits sympathetic activation during mental stress in advanced heart failure patients. J Card Fail. 2002 Dec; 8(6):399-406. Middlekauff HR, Hui K, Yu JL, Hamilton MA, Fonarow GC, Moriguchi J, Maclellan WR, Hage A. PMID: 12528093.
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    85. Exaggerated muscle mechanoreflex control of reflex renal vasoconstriction in heart failure. J Appl Physiol (1985). 2001 May; 90(5):1714-9. Middlekauff HR, Nitzsche EU, Hoh CK, Hamilton MA, Fonarow GC, Hage A, Moriguchi JD. PMID: 11299260.
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    86. Acupuncture effects on reflex responses to mental stress in humans. Am J Physiol Regul Integr Comp Physiol. 2001 May; 280(5):R1462-8. Middlekauff HR, Yu JL, Hui K. PMID: 11294769.
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    87. Adenosine enhances neuroexcitability by inhibiting a slow postspike afterhyperpolarization in rabbit vagal afferent neurons. Circulation. 2001 Mar 06; 103(9):1325-9. Middlekauff HR, Doering A, Weiss JN. PMID: 11238280.
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    88. Abnormal neurovascular control during exercise is linked to heart failure severity. Am J Physiol Heart Circ Physiol. 2001 Mar; 280(3):H1286-92. Negrão CE, Rondon MU, Tinucci T, Alves MJ, Roveda F, Braga AM, Reis SF, Nastari L, Barretto AC, Krieger EM, Middlekauff HR. PMID: 11179075.
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    89. Exaggerated renal vasoconstriction during exercise in heart failure patients. Circulation. 2000 Feb 22; 101(7):784-9. Middlekauff HR, Nitzsche EU, Hoh CK, Hamilton MA, Fonarow GC, Hage A, Moriguchi JD. PMID: 10683353.
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    90. Impaired endothelium-mediated vasodilation is not the principal cause of vasoconstriction in heart failure. Am J Physiol Heart Circ Physiol. 2000 Jan; 278(1):H168-74. Negrao CE, Hamilton MA, Fonarow GC, Hage A, Moriguchi JD, Middlekauff HR. PMID: 10644596.
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    91. Heart failure: Part II. West J Med. 1999 Jun; 170(6):339-42. Wilkes MS, Middlekauff H, Hoffman JR. PMID: 10443162; PMCID: PMC1305689.
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    92. Heart failure: Part I. First hospitalization and post-hospital care. West J Med. 1999 May; 170(5):268-73. Wilkes MS, Middlekauff H, Hoffman JR. PMID: 10379217; PMCID: PMC1305582.
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    93. The treatment of heart failure: the role of neurohumoral activation. Intern Med. 1998 Feb; 37(2):112-22. Middlekauff HR, Mark AL. PMID: 9550589.
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    94. Impact of acute mental stress on sympathetic nerve activity and regional blood flow in advanced heart failure: implications for 'triggering' adverse cardiac events. Circulation. 1997 Sep 16; 96(6):1835-42. Middlekauff HR, Nguyen AH, Negrao CE, Nitzsche EU, Hoh CK, Natterson BA, Hamilton MA, Fonarow GC, Hage A, Moriguchi JD. PMID: 9323069.
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    95. Mechanisms and implications of autonomic nervous system dysfunction in heart failure. Curr Opin Cardiol. 1997 May; 12(3):265-75. Middlekauff HR. PMID: 9243084.
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    96. Modulation of renal cortical blood flow during static exercise in humans. Circ Res. 1997 Jan; 80(1):62-8. Middlekauff HR, Nitzsche EU, Nguyen AH, Hoh CK, Gibbs GG. PMID: 8978323.
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    97. Improving survival for patients with atrial fibrillation and advanced heart failure. J Am Coll Cardiol. 1996 Nov 15; 28(6):1458-63. Stevenson WG, Stevenson LW, Middlekauff HR, Fonarow GC, Hamilton MA, Woo MA, Saxon LA, Natterson PD, Steimle A, Walden JA, Tillisch JH. PMID: 8917258.
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    98. Dynamics of muscle sympathetic nerve activity in advanced heart failure patients. Am J Physiol. 1996 Nov; 271(5 Pt 2):H1962-9. Nguyen AH, Garfinkel A, Walter DO, Hamilton MA, Fonarow GC, Moriguchi JD, Hage A, Weiss JN, Middlekauff HR. PMID: 8945915.
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    99. Improving survival for patients with advanced heart failure: a study of 737 consecutive patients. J Am Coll Cardiol. 1995 Nov 15; 26(6):1417-23. Stevenson WG, Stevenson LW, Middlekauff HR, Fonarow GC, Hamilton MA, Woo MA, Saxon LA, Natterson PD, Steimle A, Walden JA, et al. PMID: 7594064.
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    100. Amiodarone and torsades de pointes in patients with advanced heart failure. Am J Cardiol. 1995 Sep 01; 76(7):499-502. Middlekauff HR, Stevenson WG, Saxon LA, Stevenson LW. PMID: 7653452.
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    101. Evidence for preserved cardiopulmonary baroreflex control of renal cortical blood flow in humans with advanced heart failure. A positron emission tomography study. Circulation. 1995 Aug 01; 92(3):395-401. Middlekauff HR, Nitzsche EU, Hamilton MA, Schelbert HR, Fonarow GC, Moriguchi JD, Hage A, Saleh S, Gibbs GG. PMID: 7634454.
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    102. Relation of pace mapping QRS configuration and conduction delay to ventricular tachycardia reentry circuits in human infarct scars. J Am Coll Cardiol. 1995 Aug; 26(2):481-8. Stevenson WG, Sager PT, Natterson PD, Saxon LA, Middlekauff HR, Wiener I. PMID: 7608454.
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    103. Long-term efficacy of amiodarone for the maintenance of normal sinus rhythm in patients with refractory atrial fibrillation or flutter. Am J Cardiol. 1995 Jul 01; 76(1):47-50. Chun SH, Sager PT, Stevenson WG, Nademanee K, Middlekauff HR, Singh BN. PMID: 7793402.
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    104. Morning sympathetic nerve activity is not increased in humans. Implications for mechanisms underlying the circadian pattern of cardiac risk. Circulation. 1995 May 15; 91(10):2549-55. Middlekauff HR, Sontz EM. PMID: 7743616.
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    105. Antiarrhythmic prophylaxis vs warfarin anticoagulation to prevent thromboembolic events among patients with atrial fibrillation. A decision analysis. Arch Intern Med. 1995 May 08; 155(9):913-20. Middlekauff HR, Stevenson WG, Gornbein JA. PMID: 7726699.
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    106. Risk of arterial embolization in 224 patients awaiting cardiac transplantation. Am Heart J. 1995 Mar; 129(3):564-70. Natterson PD, Stevenson WG, Saxon LA, Middlekauff HR, Stevenson LW. PMID: 7872188.
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    107. Independent control of skin and muscle sympathetic nerve activity in patients with heart failure. Circulation. 1994 Oct; 90(4):1794-8. Middlekauff HR, Hamilton MA, Stevenson LW, Mark AL. PMID: 7923664.
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    108. Complex heart rate variability and serum norepinephrine levels in patients with advanced heart failure. J Am Coll Cardiol. 1994 Mar 01; 23(3):565-9. Woo MA, Stevenson WG, Moser DK, Middlekauff HR. PMID: 8113535.
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    109. Sudden death prevention in patients with advanced ventricular dysfunction. Circulation. 1993 Dec; 88(6):2953-61. Stevenson WG, Stevenson LW, Middlekauff HR, Saxon LA. PMID: 8252708.
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    110. Low-dose amiodarone for atrial fibrillation. Am J Cardiol. 1993 Nov 26; 72(16):75F-81F. Middlekauff HR, Wiener I, Stevenson WG. PMID: 8237834.
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    111. Transesophageal echocardiography during radiofrequency catheter ablation of ventricular tachycardia. Am J Cardiol. 1993 Sep 15; 72(9):658-61. Saxon LA, Stevenson WG, Fonarow GC, Middlekauff HR, Yeatman LA, Sherman CT, Child JS. PMID: 8249840.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    112. Predicting death from progressive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol. 1993 Jul 01; 72(1):62-5. Saxon LA, Stevenson WG, Middlekauff HR, Fonarow G, Woo M, Moser D, Stevenson LW. PMID: 8517430.
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    113. Increased risk of progressive hemodynamic deterioration in advanced heart failure patients requiring permanent pacemakers. Am Heart J. 1993 May; 125(5 Pt 1):1306-10. Saxon LA, Stevenson WG, Middlekauff HR, Stevenson LW. PMID: 8480582.
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    114. Syncope in advanced heart failure: high risk of sudden death regardless of origin of syncope. J Am Coll Cardiol. 1993 Jan; 21(1):110-6. Middlekauff HR, Stevenson WG, Stevenson LW, Saxon LA. PMID: 8417050.
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    115. Amiodarone therapy does not compromise subsequent heart transplantation. J Am Coll Cardiol. 1992 Dec; 20(7):1556-61. Chelimsky-Fallick C, Middlekauff HR, Stevenson WG, Kobashigawa J, Saxon LA, Moriguchi J, Brownfield ED, Hamilton MA, Drinkwater D, Laks H, et al. PMID: 1452930.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCTClinical Trials
    116. Significance of aborted cardiac arrest and sustained ventricular tachycardia in patients referred for treatment therapy of advanced heart failure. Am Heart J. 1992 Jul; 124(1):123-30. Stevenson WG, Middlekauff HR, Stevenson LW, Saxon LA, Woo MA, Moser D. PMID: 1615794.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    117. Prevention of sudden death in survivors of myocardial infarction: a decision analysis approach. Am Heart J. 1992 Feb; 123(2):475-80. Middlekauff HR, Stevenson WG, Tillisch JH. PMID: 1736586.
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    118. Prognostic significance of atrial fibrillation in advanced heart failure. A study of 390 patients. Circulation. 1991 Jul; 84(1):40-8. Middlekauff HR, Stevenson WG, Stevenson LW. PMID: 2060110.
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    119. Comparison of frequency of late potentials in idiopathic dilated cardiomyopathy and ischemic cardiomyopathy with advanced congestive heart failure and their usefulness in predicting sudden death. Am J Cardiol. 1990 Nov 01; 66(15):1113-7. Middlekauff HR, Stevenson WG, Woo MA, Moser DK, Stevenson LW. PMID: 2220639.
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