Louis Alexander Saddic

Title(s)Assistant Professor-in-Residence, Anesthesiology
SchoolMedicine
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    The Identification and characterization of the methylation of Retinablastoma
    NIH F30AG034741Sep 1, 2009 - Aug 31, 2011
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Single Cell Proteomics Reveals Novel Cell Phenotypes in Marfan Mouse Aneurysm. bioRxiv. 2025 Feb 20. Saddic L, Kaneda G, Momenzadeh A, Zilberberg L, Song Y, Mastali M, Kreimer S, Hutton A, Haghani A, Meyer J, Parker S. PMID: 40027651; PMCID: PMC11870452.
      View in: PubMed   Mentions:
    2. 17 β-Estradiol Impedes Aortic Root Dilation and Rupture in Male Marfan Mice. Int J Mol Sci. 2023 Sep 01; 24(17). Saddic L, Escopete S, Zilberberg L, Kalsow S, Gupta D, Eghbali M, Parker S. PMID: 37686377; PMCID: PMC10487461.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    3. Incidence of Intraoperative Vasoplegic Syndrome in Lung Transplantation. J Cardiothorac Vasc Anesth. 2023 12; 37(12):2531-2537. Lam S, Mofidi S, Saddic L, Neelankavil J, Wingert T, Cheng D, Grogan T, Methangkool E. PMID: 37775341.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis. Circulation. 2023 08 22; 148(8):661-678. Blaser MC, Buffolo F, Halu A, Turner ME, Schlotter F, Higashi H, Pantano L, Clift CL, Saddic LA, Atkins SK, Rogers MA, Pham T, Vromman A, Shvartz E, Sukhova GK, Monticone S, Camussi G, Robson SC, Body SC, Muehlschlegel JD, Singh SA, Aikawa M, Aikawa E. PMID: 37427430; PMCID: PMC10527599.
      View in: PubMed   Mentions: 19     Fields:    
    5. 17 β-estradiol impedes aortic root dilation and rupture in male Marfan mice. bioRxiv. 2023 May 12. Saddic L, Escopete S, Zilberberg L, Kalsow S, Gupta D, Egbhali M, Parker S. PMID: 37215011; PMCID: PMC10197695.
      View in: PubMed   Mentions:
    6. Thoracic Epidural Analgesia Can be Reserved for a Specific Population of Patients Undergoing Lung Transplantation. Transplant Proc. 2023 03; 55(2):456-458. Little C, Grewe K, Gudzenko V, Hernandez-Morgan M, Saddic L. PMID: 36801176.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. The Impact of COVID-19 on Racial and Ethnic Disparities in Cardiac Procedural Care. J Cardiothorac Vasc Anesth. 2023 05; 37(5):732-747. Tien M, Saddic LA, Neelankavil JP, Shemin RJ, Williams TM. PMID: 36863983; PMCID: PMC9827732.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansPHPublic Health
    8. Quantitative Echocardiography Improves Resident Assessment of Left Ventricular Systolic Function. J Educ Perioper Med. 2022 Apr-Jun; 24(2):1-6. Wu AH, Chowdhary H, Fischer M, Salehi A, Grogan T, Saddic L, Neelankavil J, Harvey R. PMID: 36051400; PMCID: PMC9426259.
      View in: PubMed   Mentions:
    9. Proteomic analysis of descending thoracic aorta identifies unique and universal signatures of aneurysm and dissection. JVS Vasc Sci. 2022; 3:85-181. Saddic L, Orosco A, Guo D, Milewicz DM, Troxlair D, Heide RV, Herrington D, Wang Y, Azizzadeh A, Parker SJ. PMID: 35280433; PMCID: PMC8914561.
      View in: PubMed   Mentions: 9  
    10. Novel and Annotated Long Noncoding RNAs Associated with Ischemia in the Human Heart. Int J Mol Sci. 2021 Oct 20; 22(21). Ward Z, Schmeier S, Saddic L, Sigurdsson MI, Cameron VA, Pearson J, Miller A, Morley-Bunker A, Gorham J, Seidman JG, Moravec CS, Sweet WE, Aranki SF, Body S, Muehlschlegel JD, Pilbrow AP. PMID: 34768754; PMCID: PMC8583240.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    11. Intraoperative diastolic function assessed by TEE does not agree with preoperative diastolic function grade in CABG patients. Echocardiography. 2021 08; 38(8):1282-1289. Harvey R, Chellappa V, Mofidi S, Scovotti J, Neelankavil JP, Saddic L. PMID: 34255390.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Variant curation expert panel recommendations for RYR1 pathogenicity classifications in malignant hyperthermia susceptibility. Genet Med. 2021 07; 23(7):1288-1295. Johnston JJ, Dirksen RT, Girard T, Gonsalves SG, Hopkins PM, Riazi S, Saddic LA, Sambuughin N, Saxena R, Stowell K, Weber J, Rosenberg H, Biesecker LG. PMID: 33767344; PMCID: PMC8263483.
      View in: PubMed   Mentions: 31     Fields:    
    13. Transcriptomic Analysis of Right Ventricular Remodeling in Two Rat Models of Pulmonary Hypertension: Identification and Validation of Epithelial-to-Mesenchymal Transition in Human Right Ventricular Failure. Circ Heart Fail. 2021 02; 14(2):e007058. Park JF, Clark VR, Banerjee S, Hong J, Razee A, Williams T, Fishbein G, Saddic L, Umar S. PMID: 33541093; PMCID: PMC7887079.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    14. Double-edged sword of ALDH2 mutations: one polymorphism can both benefit and harm the cardiovascular system. Eur Heart J. 2020 07 07; 41(26):2453-2455. Bartoli-Leonard F, Saddic L, Aikawa E. PMID: 32585692; PMCID: PMC7340353.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    15. Progression of myocardial ischemia leads to unique changes in immediate-early gene expression in the spinal cord dorsal horn. Am J Physiol Heart Circ Physiol. 2018 12 01; 315(6):H1592-H1601. Saddic LA, Howard-Quijano K, Kipke J, Kubo Y, Dale EA, Hoover D, Shivkumar K, Eghbali M, Mahajan A. PMID: 30216122; PMCID: PMC6336975.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    16. Joint analysis of left ventricular expression and circulating plasma levels of Omentin after myocardial ischemia. Cardiovasc Diabetol. 2017 07 07; 16(1):87. Saddic LA, Nicoloro SM, Gupta OT, Czech MP, Gorham J, Shernan SK, Seidman CE, Seidman JG, Aranki SF, Body SC, Fitzgibbons TP, Muehlschlegel JD. PMID: 28687077; PMCID: PMC5501278.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    17. Post-operative atrial fibrillation examined using whole-genome RNA sequencing in human left atrial tissue. BMC Med Genomics. 2017 05 02; 10(1):25. Sigurdsson MI, Saddic L, Heydarpour M, Chang TW, Shekar P, Aranki S, Couper GS, Shernan SK, Muehlschlegel JD, Body SC. PMID: 28464817; PMCID: PMC5414158.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCellsCTClinical Trials
    18. The Long Noncoding RNA Landscape of the Ischemic Human Left Ventricle. Circ Cardiovasc Genet. 2017 Jan; 10(1). Saddic LA, Sigurdsson MI, Chang TW, Mazaika E, Heydarpour M, Shernan SK, Seidman CE, Seidman JG, Aranki SF, Body SC, Muehlschlegel JD. PMID: 28115490; PMCID: PMC5302288.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    19. Allele-specific expression in the human heart and its application to postoperative atrial fibrillation and myocardial ischemia. Genome Med. 2016 12 06; 8(1):127. Sigurdsson MI, Saddic L, Heydarpour M, Chang TW, Shekar P, Aranki S, Couper GS, Shernan SK, Seidman JG, Body SC, Muehlschlegel JD. PMID: 27923400; PMCID: PMC5139013.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    20. Duration of Postoperative Atrial Fibrillation After Cardiac Surgery Is Associated With Worsened Long-Term Survival. Ann Thorac Surg. 2016 Dec; 102(6):2018-2026. Sigurdsson MI, Longford NT, Heydarpour M, Saddic L, Chang TW, Fox AA, Collard CD, Aranki S, Shekar P, Shernan SK, Muehlschlegel JD, Body SC. PMID: 27424470; PMCID: PMC6506267.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    21. Sarco"MiR" friend or foe: a perspective on the mechanisms of doxorubicin-induced cardiomyopathy. Ann Transl Med. 2016 May; 4(10):203. Saddic LA, Muehlschlegel JD. PMID: 27294099; PMCID: PMC4885903.
      View in: PubMed   Mentions: 5  
    22. Integrated microRNA and mRNA responses to acute human left ventricular ischemia. Physiol Genomics. 2015 Oct; 47(10):455-62. Saddic LA, Chang TW, Sigurdsson MI, Heydarpour M, Raby BA, Shernan SK, Aranki SF, Body SC, Muehlschlegel JD. PMID: 26175501; PMCID: PMC4593826.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCTClinical Trials
    23. Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway. J Exp Med. 2011 Sep 26; 208(10):1963-76. Viatour P, Ehmer U, Saddic LA, Dorrell C, Andersen JB, Lin C, Zmoos AF, Mazur PK, Schaffer BE, Ostermeier A, Vogel H, Sylvester KG, Thorgeirsson SS, Grompe M, Sage J. PMID: 21875955; PMCID: PMC3182062.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansAnimalsCells
    24. Functional interactions between retinoblastoma and c-MYC in a mouse model of hepatocellular carcinoma. PLoS One. 2011 May 06; 6(5):e19758. Saddic LA, Wirt S, Vogel H, Felsher DW, Sage J. PMID: 21573126; PMCID: PMC3089631.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    25. G1 arrest and differentiation can occur independently of Rb family function. J Cell Biol. 2010 Nov 15; 191(4):809-25. Wirt SE, Adler AS, Gebala V, Weimann JM, Schaffer BE, Saddic LA, Viatour P, Vogel H, Chang HY, Meissner A, Sage J. PMID: 21059851; PMCID: PMC2983066.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    26. Methylation of the retinoblastoma tumor suppressor by SMYD2. J Biol Chem. 2010 Nov 26; 285(48):37733-40. Saddic LA, West LE, Aslanian A, Yates JR, Rubin SM, Gozani O, Sage J. PMID: 20870719; PMCID: PMC2988378.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansCells
    27. The LEAFY target LMI1 is a meristem identity regulator and acts together with LEAFY to regulate expression of CAULIFLOWER. Development. 2006 May; 133(9):1673-82. Saddic LA, Huvermann B, Bezhani S, Su Y, Winter CM, Kwon CS, Collum RP, Wagner D. PMID: 16554366.
      View in: PubMed   Mentions: 61     Fields:    Translation:Animals
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