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Bhowmick, Neil Adri

Title(s)Professor-in-Residence, Medicine
SchoolMed - Hematology And Oncology
Phone310-423-5992
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    Collapse Research 
    Collapse Research Activities and Funding
    Determinants of Liver Metastasis
    NIH/NCI P01CA233452Jan 21, 2020 - Dec 31, 2024
    Role: Co-Principal Investigator
    A multidisciplinary training program in prostate cancer
    NIH/NCI T32CA240172Jul 1, 2019 - Jun 30, 2024
    Role: Principal Investigator
    Society for Basic Urologic Research (SBUR) 2013 Fall Symposium
    NIH/NIDDK R13DK101308Sep 15, 2013 - Jan 31, 2014
    Role: Principal Investigator
    Paracrine Mechanisms of Prostate Cancer Metastatic Progression
    VA I01BX001040Oct 1, 2012 - Sep 30, 2016
    Role: Principal Investigator
    Differential TGF-Beta Signaling in Bone Microenviroment: Impact on Tumor Growth
    NIH/NCI U01CA143057Apr 7, 2011 - Mar 31, 2016
    Role: Co-Principal Investigator
    TGFBeta Signaling in the Bladder Stroma
    NIH/NIDDK R21DK069527Sep 30, 2004 - Aug 31, 2008
    Role: Principal Investigator
    TGF Beta Signals in Prostate Stromal-Epithelial Interactions
    NIH/NCI R01CA108646Aug 1, 2004 - May 31, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Vidal AC, Duong F, Howard LE, Wiggins E, Freedland SJ, Bhowmick NA, Gong J. Soluble Endoglin (sCD105) as a Novel Biomarker for Detecting Aggressive Prostate Cancer. Anticancer Res. 2020 Mar; 40(3):1459-1462. PMID: 32132043.
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    2. Placencio-Hickok VR, Madhav A, Kim S, Duong F, Angara B, Liu Z, Bhowmick NA. Soluble CD105 is prognostic of disease recurrence in prostate cancer patients. Endocr Relat Cancer. 2020 Jan; 27(1):1-9. PMID: 31648185.
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    3. Mishra R, Haldar S, Suchanti S, Bhowmick NA. Epigenetic changes in fibroblasts drive cancer metabolism and differentiation. Endocr Relat Cancer. 2019 Dec; 26(12):R673-R688. PMID: 31627186.
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    4. Cheng R, Billet S, Liu C, Haldar S, Choudhury D, Tripathi M, Hav M, Merchant A, Hu T, Huang H, Zhou H, Bhowmick NA. Periodontal inflammation recruits distant metastatic breast cancer cells by increasing myeloid-derived suppressor cells. Oncogene. 2020 Feb; 39(7):1543-1556. PMID: 31685946.
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    5. Gottlieb RA, Bhowmick NA. Pushing the Heart Over a KLF(15). J Am Coll Cardiol. 2019 Oct 08; 74(14):1820-1822. PMID: 31582142.
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    6. Ohashi K, Wang Z, Yang YM, Billet S, Tu W, Pimienta M, Cassel SL, Pandol SJ, Lu SC, Sutterwala FS, Bhowmick N, Seki E. NOD-like receptor C4 Inflammasome Regulates the Growth of Colon Cancer Liver Metastasis in NAFLD. Hepatology. 2019 Nov; 70(5):1582-1599. PMID: 31044438.
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    7. Mishra R, Bhowmick NA. Visualization of Macropinocytosis in Prostate Fibroblasts. Bio Protoc. 2019 May 20; 9(10). PMID: 31475219.
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    8. Brennen WN, Schweizer MT, Wang H, Bivalacqua TJ, Partin AW, Lim SJ, Chapman C, Abdallah R, Levy O, Bhowmick NA, Karp JM, De Marzo A, Isaacs JT, Denmeade SR. In Reply. Stem Cells Transl Med. 2019 07; 8(7):739-740. PMID: 30925030.
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    9. Feng Y, Sessions EH, Zhang F, Ban F, Placencio-Hickok V, Ma CT, Zeng FY, Pass I, Terry DB, Cadwell G, Bankston LA, Liddington RC, Chung TDY, Pinkerton AB, Sergienko E, Gleave M, Bhowmick NA, Jackson MR, Cherkasov A, Ronai ZA. Identification and characterization of small molecule inhibitors of the ubiquitin ligases Siah1/2 in melanoma and prostate cancer cells. Cancer Lett. 2019 05 01; 449:145-162. PMID: 30771432.
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    10. Uche A, Sila C, Tanoura T, Yeh J, Bhowmick N, Posadas E, Figlin R, Gong J. Brain Complete Response to Cabozantinib prior to Radiation Therapy in Metastatic Renal Cell Carcinoma. Case Rep Urol. 2019; 2019:6769017. PMID: 30906615.
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    11. Schweizer MT, Wang H, Bivalacqua TJ, Partin AW, Lim SJ, Chapman C, Abdallah R, Levy O, Bhowmick NA, Karp JM, De Marzo A, Isaacs JT, Brennen WN, Denmeade SR. A Phase I Study to Assess the Safety and Cancer-Homing Ability of Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells in Men with Localized Prostate Cancer. Stem Cells Transl Med. 2019 05; 8(5):441-449. PMID: 30735000.
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    12. Kato M, Placencio-Hickok VR, Madhav A, Haldar S, Tripathi M, Billet S, Mishra R, Smith B, Rohena-Rivera K, Agarwal P, Duong F, Angara B, Hickok D, Liu Z, Bhowmick NA. Heterogeneous cancer-associated fibroblast population potentiates neuroendocrine differentiation and castrate resistance in a CD105-dependent manner. Oncogene. 2019 01; 38(5):716-730. PMID: 30177832.
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    13. Edderkaoui M, Chheda C, Soufi B, Zayou F, Hu RW, Ramanujan VK, Pan X, Boros LG, Tajbakhsh J, Madhav A, Bhowmick NA, Wang Q, Lewis M, Tuli R, Habtezion A, Murali R, Pandol SJ. An Inhibitor of GSK3B and HDACs Kills Pancreatic Cancer Cells and Slows Pancreatic Tumor Growth and Metastasis in Mice. Gastroenterology. 2018 12; 155(6):1985-1998.e5. PMID: 30144430.
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    14. Cavassani KA, Meza RJ, Habiel DM, Chen JF, Montes A, Tripathi M, Martins GA, Crother TR, You S, Hogaboam CM, Bhowmick N, Posadas EM. Circulating monocytes from prostate cancer patients promote invasion and motility of epithelial cells. Cancer Med. 2018 09; 7(9):4639-4649. PMID: 30094958.
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    15. Mishra R, Haldar S, Placencio V, Madhav A, Rohena-Rivera K, Agarwal P, Duong F, Angara B, Tripathi M, Liu Z, Gottlieb RA, Wagner S, Posadas EM, Bhowmick NA. Stromal epigenetic alterations drive metabolic and neuroendocrine prostate cancer reprogramming. J Clin Invest. 2018 10 01; 128(10):4472-4484. PMID: 30047926.
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    16. Rohena-Rivera K, Bhowmick NA. Notch inhibitor screening reveals an unexpected HES1 heterodimer. J Biol Chem. 2018 05 25; 293(21):8295-8296. PMID: 29802140.
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    17. Madhav A, Andres A, Duong F, Mishra R, Haldar S, Liu Z, Angara B, Gottlieb R, Zumsteg ZS, Bhowmick NA. Antagonizing CD105 enhances radiation sensitivity in prostate cancer. Oncogene. 2018 08; 37(32):4385-4397. PMID: 29717261.
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    18. Pollan SG, Huang F, Sperger JM, Lang JM, Morrissey C, Cress AE, Chu CY, Bhowmick NA, You S, Freeman MR, Spassov DS, Moasser MM, Carter WG, Satapathy SR, Shah K, Knudsen BS. Regulation of inside-out ß1-integrin activation by CDCP1. Oncogene. 2018 05; 37(21):2817-2836. PMID: 29511352.
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    19. Salem AF, Wang S, Billet S, Chen JF, Udompholkul P, Gambini L, Baggio C, Tseng HR, Posadas EM, Bhowmick NA, Pellecchia M. Reduction of Circulating Cancer Cells and Metastases in Breast-Cancer Models by a Potent EphA2-Agonistic Peptide-Drug Conjugate. J Med Chem. 2018 03 08; 61(5):2052-2061. PMID: 29470068.
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    20. Cheng R, Liu W, Zhang R, Feng Y, Bhowmick NA, Hu T. Porphyromonas gingivalis-Derived Lipopolysaccharide Combines Hypoxia to Induce Caspase-1 Activation in Periodontitis. Front Cell Infect Microbiol. 2017; 7:474. PMID: 29184853.
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    21. Tripathi M, Nandana S, Billet S, Cavassani KA, Mishra R, Chung LWK, Posadas EM, Bhowmick NA. Modulation of cabozantinib efficacy by the prostate tumor microenvironment. Oncotarget. 2017 Oct 20; 8(50):87891-87902. PMID: 29152128.
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    22. Tomasi ML, Cossu C, Spissu Y, Floris A, Ryoo M, Iglesias-Ara A, Wang Q, Pandol SJ, Bhowmick NA, Seki E, Posadas EM, Lu SC. S-adenosylmethionine and methylthioadenosine inhibit cancer metastasis by targeting microRNA 34a/b-methionine adenosyltransferase 2A/2B axis. Oncotarget. 2017 Oct 03; 8(45):78851-78869. PMID: 29108270.
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    23. Recouvreux MV, Wu JB, Gao AC, Zonis S, Chesnokova V, Bhowmick N, Chung LW, Melmed S. Androgen Receptor Regulation of Local Growth Hormone in Prostate Cancer Cells. Endocrinology. 2017 07 01; 158(7):2255-2268. PMID: 28444169.
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    24. Han B, Bhowmick N, Qu Y, Chung S, Giuliano AE, Cui X. FOXC1: an emerging marker and therapeutic target for cancer. Oncogene. 2017 07 13; 36(28):3957-3963. PMID: 28288141.
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    25. Smith B, Agarwal P, Bhowmick NA. MicroRNA applications for prostate, ovarian and breast cancer in the era of precision medicine. Endocr Relat Cancer. 2017 05; 24(5):R157-R172. PMID: 28289080.
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    26. Minciacchi VR, Spinelli C, Reis-Sobreiro M, Cavallini L, You S, Zandian M, Li X, Mishra R, Chiarugi P, Adam RM, Posadas EM, Viglietto G, Freeman MR, Cocucci E, Bhowmick NA, Di Vizio D. MYC Mediates Large Oncosome-Induced Fibroblast Reprogramming in Prostate Cancer. Cancer Res. 2017 05 01; 77(9):2306-2317. PMID: 28202510.
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    27. Nandana S, Tripathi M, Duan P, Chu CY, Mishra R, Liu C, Jin R, Yamashita H, Zayzafoon M, Bhowmick NA, Zhau HE, Matusik RJ, Chung LW. Bone Metastasis of Prostate Cancer Can Be Therapeutically Targeted at the TBX2-WNT Signaling Axis. Cancer Res. 2017 03 15; 77(6):1331-1344. PMID: 28108510.
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    28. Haldar S, Dru C, Mishra R, Tripathi M, Duong F, Angara B, Fernandez A, Arditi M, Bhowmick NA. Histone deacetylase inhibitors mediate DNA damage repair in ameliorating hemorrhagic cystitis. Sci Rep. 2016 12 20; 6:39257. PMID: 27995963.
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    29. Levy O, Brennen WN, Han E, Rosen DM, Musabeyezu J, Safaee H, Ranganath S, Ngai J, Heinelt M, Milton Y, Wang H, Bhagchandani SH, Joshi N, Bhowmick N, Denmeade SR, Isaacs JT, Karp JM. A prodrug-doped cellular Trojan Horse for the potential treatment of prostate cancer. Biomaterials. 2016 Jun; 91:140-150. PMID: 27019026.
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    30. Smith BN, Bhowmick NA. Role of EMT in Metastasis and Therapy Resistance. J Clin Med. 2016 Jan 27; 5(2). PMID: 26828526.
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    31. Bianchi-Frias D, Basom R, Delrow JJ, Coleman IM, Dakhova O, Qu X, Fang M, Franco OE, Ericson NG, Bielas JH, Hayward SW, True L, Morrissey C, Brown L, Bhowmick NA, Rowley D, Ittmann M, Nelson PS. Cells Comprising the Prostate Cancer Microenvironment Lack Recurrent Clonal Somatic Genomic Aberrations. Mol Cancer Res. 2016 Apr; 14(4):374-84. PMID: 26753621.
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    32. Gururajan M, Cavassani KA, Sievert M, Duan P, Lichterman J, Huang JM, Smith B, You S, Nandana S, Chu GC, Mink S, Josson S, Liu C, Morello M, Jones LW, Kim J, Freeman MR, Bhowmick N, Zhau HE, Chung LW, Posadas EM. SRC family kinase FYN promotes the neuroendocrine phenotype and visceral metastasis in advanced prostate cancer. Oncotarget. 2015 Dec 29; 6(42):44072-83. PMID: 26624980.
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    33. Cheng R, Hu T, Bhowmick NA. Be resistant to apoptosis: a host factor from gingival fibroblasts. Cell Death Dis. 2015 Dec 03; 6:e2009. PMID: 26633715.
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    34. Cheng R, Choudhury D, Liu C, Billet S, Hu T, Bhowmick NA. Gingival fibroblasts resist apoptosis in response to oxidative stress in a model of periodontal diseases. Cell Death Discov. 2015; 1:15046. PMID: 27551475.
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    35. Meng X, Vander Ark A, Lee P, Hostetter G, Bhowmick NA, Matrisian LM, Williams BO, Miranti CK, Li X. Myeloid-specific TGF-ß signaling in bone promotes basic-FGF and breast cancer bone metastasis. Oncogene. 2016 05 05; 35(18):2370-8. PMID: 26279296.
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    36. Arumuggam N, Bhowmick NA, Rupasinghe HP. A Review: Phytochemicals Targeting JAK/STAT Signaling and IDO Expression in Cancer. Phytother Res. 2015 Jun; 29(6):805-17. PMID: 25787773.
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    37. Haldar S, Dru C, Choudhury D, Mishra R, Fernandez A, Biondi S, Liu Z, Shimada K, Arditi M, Bhowmick NA. Inflammation and pyroptosis mediate muscle expansion in an interleukin-1ß (IL-1ß)-dependent manner. J Biol Chem. 2015 Mar 06; 290(10):6574-83. PMID: 25596528.
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    38. Haldar S, Dru C, Bhowmick NA. Mechanisms of hemorrhagic cystitis. Am J Clin Exp Urol. 2014; 2(3):199-208. PMID: 25374922.
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    39. Banerjee J, Mishra R, Li X, Jackson RS, Sharma A, Bhowmick NA. A reciprocal role of prostate cancer on stromal DNA damage. Oncogene. 2014 Oct 09; 33(41):4924-31. PMID: 24141771.
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    40. Morello M, Minciacchi VR, de Candia P, Yang J, Posadas E, Kim H, Griffiths D, Bhowmick N, Chung LW, Gandellini P, Freeman MR, Demichelis F, Di Vizio D. Large oncosomes mediate intercellular transfer of functional microRNA. Cell Cycle. 2013 Nov 15; 12(22):3526-36. PMID: 24091630.
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    41. Qi J, Tripathi M, Mishra R, Sahgal N, Fazli L, Fazil L, Ettinger S, Placzek WJ, Claps G, Chung LW, Bowtell D, Gleave M, Bhowmick N, Ronai ZA. The E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity. Cancer Cell. 2013 Mar 18; 23(3):332-46. PMID: 23518348.
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    42. Zhang H, Berel D, Wang Y, Li P, Bhowmick NA, Figlin RA, Kim HL. A comparison of Ku0063794, a dual mTORC1 and mTORC2 inhibitor, and temsirolimus in preclinical renal cell carcinoma models. PLoS One. 2013; 8(1):e54918. PMID: 23349989.
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    43. Wang S, Noberini R, Stebbins JL, Das S, Zhang Z, Wu B, Mitra S, Billet S, Fernandez A, Bhowmick NA, Kitada S, Pasquale EB, Fisher PB, Pellecchia M. Targeted delivery of paclitaxel to EphA2-expressing cancer cells. Clin Cancer Res. 2013 Jan 01; 19(1):128-37. PMID: 23155185.
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    44. Bhowmick NA. Metastatic ability: adapting to a tissue site unseen. Cancer Cell. 2012 Nov 13; 22(5):563-4. PMID: 23153528.
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    45. Di Vizio D, Morello M, Dudley AC, Schow PW, Adam RM, Morley S, Mulholland D, Rotinen M, Hager MH, Insabato L, Moses MA, Demichelis F, Lisanti MP, Wu H, Klagsbrun M, Bhowmick NA, Rubin MA, D'Souza-Schorey C, Freeman MR. Large oncosomes in human prostate cancer tissues and in the circulation of mice with metastatic disease. Am J Pathol. 2012 Nov; 181(5):1573-84. PMID: 23022210.
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    46. Jackson RS, Placzek W, Fernandez A, Ziaee S, Chu CY, Wei J, Stebbins J, Kitada S, Fritz G, Reed JC, Chung LW, Pellecchia M, Bhowmick NA. Sabutoclax, a Mcl-1 antagonist, inhibits tumorigenesis in transgenic mouse and human xenograft models of prostate cancer. Neoplasia. 2012 Jul; 14(7):656-65. PMID: 22904682.
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    47. Tripathi M, Billet S, Bhowmick NA. Understanding the role of stromal fibroblasts in cancer progression. Cell Adh Migr. 2012 May-Jun; 6(3):231-5. PMID: 22568983.
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    48. Li X, Sterling JA, Fan KH, Vessella RL, Shyr Y, Hayward SW, Matrisian LM, Bhowmick NA. Loss of TGF-ß responsiveness in prostate stromal cells alters chemokine levels and facilitates the development of mixed osteoblastic/osteolytic bone lesions. Mol Cancer Res. 2012 Apr; 10(4):494-503. PMID: 22290877.
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    49. Ge L, Smail M, Meng W, Shyr Y, Ye F, Fan KH, Li X, Zhou HM, Bhowmick NA. Yes-associated protein expression in head and neck squamous cell carcinoma nodal metastasis. PLoS One. 2011; 6(11):e27529. PMID: 22096589.
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    50. Chen M, Yeh CR, Chang HC, Vitkus S, Wen XQ, Bhowmick NA, Wolfe A, Yeh S. Loss of epithelial oestrogen receptor a inhibits oestrogen-stimulated prostate proliferation and squamous metaplasia via in vivo tissue selective knockout models. J Pathol. 2012 Jan; 226(1):17-27. PMID: 22069040.
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    51. Stabler S, Koyama T, Zhao Z, Martinez-Ferrer M, Allen RH, Luka Z, Loukachevitch LV, Clark PE, Wagner C, Bhowmick NA. Serum methionine metabolites are risk factors for metastatic prostate cancer progression. PLoS One. 2011; 6(8):e22486. PMID: 21853037.
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    52. Kiskowski MA, Jackson RS, Banerjee J, Li X, Kang M, Iturregui JM, Franco OE, Hayward SW, Bhowmick NA. Role for stromal heterogeneity in prostate tumorigenesis. Cancer Res. 2011 May 15; 71(10):3459-70. PMID: 21444670.
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    53. Franco OE, Jiang M, Strand DW, Peacock J, Fernandez S, Jackson RS, Revelo MP, Bhowmick NA, Hayward SW. Altered TGF-ß signaling in a subpopulation of human stromal cells promotes prostatic carcinogenesis. Cancer Res. 2011 Feb 15; 71(4):1272-81. PMID: 21303979.
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    54. Woo LL, Tanaka ST, Anumanthan G, Pope JC, Thomas JC, Adams MC, Brock JW, Bhowmick NA. Mesenchymal stem cell recruitment and improved bladder function after bladder outlet obstruction: preliminary data. J Urol. 2011 Mar; 185(3):1132-8. PMID: 21255803.
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    55. Placencio VR, Li X, Sherrill TP, Fritz G, Bhowmick NA. Bone marrow derived mesenchymal stem cells incorporate into the prostate during regrowth. PLoS One. 2010 Sep 23; 5(9):e12920. PMID: 20886110.
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    56. Li X, Martinez-Ferrer M, Botta V, Uwamariya C, Banerjee J, Bhowmick NA. Epithelial Hic-5/ARA55 expression contributes to prostate tumorigenesis and castrate responsiveness. Oncogene. 2011 Jan 13; 30(2):167-77. PMID: 20818421.
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    57. Ge L, Meng W, Zhou H, Bhowmick N. Could stroma contribute to field cancerization? Med Hypotheses. 2010 Jul; 75(1):26-31. PMID: 20149555.
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    58. Martinez-Ferrer M, Afshar-Sherif AR, Uwamariya C, de Crombrugghe B, Davidson JM, Bhowmick NA. Dermal transforming growth factor-beta responsiveness mediates wound contraction and epithelial closure. Am J Pathol. 2010 Jan; 176(1):98-107. PMID: 19959810.
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    59. Anumanthan G, Tanaka ST, Adams CM, Thomas JC, Wills ML, Adams MC, Hayward SW, Matusik RJ, Bhowmick NA, Brock JW, Pope JC. Bladder stromal loss of transforming growth factor receptor II decreases fibrosis after bladder obstruction. J Urol. 2009 Oct; 182(4 Suppl):1775-80. PMID: 19692014.
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    60. Tanaka ST, Martinez-Ferrer M, Makari JH, Wills ML, Thomas JC, Adams MC, Brock JW, Pope JC, Bhowmick NA. Recruitment of bone marrow derived cells to the bladder after bladder outlet obstruction. J Urol. 2009 Oct; 182(4 Suppl):1769-74. PMID: 19692058.
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    61. Boomershine CS, Chamberlain A, Kendall P, Afshar-Sharif AR, Huang H, Washington MK, Lawson WE, Thomas JW, Blackwell TS, Bhowmick NA. Autoimmune pancreatitis results from loss of TGFbeta signalling in S100A4-positive dendritic cells. Gut. 2009 Sep; 58(9):1267-74. PMID: 19625278.
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    62. Lu Q, Zhang J, Allison R, Gay H, Yang WX, Bhowmick NA, Frelix G, Shappell S, Chen YH. Identification of extracellular delta-catenin accumulation for prostate cancer detection. Prostate. 2009 Mar 01; 69(4):411-8. PMID: 19116988.
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    63. Blum DL, Koyama T, M'Koma AE, Iturregui JM, Martinez-Ferrer M, Uwamariya C, Smith JA, Clark PE, Bhowmick NA. Chemokine markers predict biochemical recurrence of prostate cancer following prostatectomy. Clin Cancer Res. 2008 Dec 01; 14(23):7790-7. PMID: 19047106.
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    64. Li X, Wang Y, Sharif-Afshar AR, Uwamariya C, Yi A, Ishii K, Hayward SW, Matusik RJ, Bhowmick NA. Urothelial transdifferentiation to prostate epithelia is mediated by paracrine TGF-beta signaling. Differentiation. 2009 Jan; 77(1):95-102. PMID: 19281768.
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    65. Li X, Placencio V, Iturregui JM, Uwamariya C, Sharif-Afshar AR, Koyama T, Hayward SW, Bhowmick NA. Prostate tumor progression is mediated by a paracrine TGF-beta/Wnt3a signaling axis. Oncogene. 2008 Nov 27; 27(56):7118-30. PMID: 18724388.
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    66. Anumanthan G, Makari JH, Honea L, Thomas JC, Wills ML, Bhowmick NA, Adams MC, Hayward SW, Matusik RJ, Brock JW, Pope JC. Directed differentiation of bone marrow derived mesenchymal stem cells into bladder urothelium. J Urol. 2008 Oct; 180(4 Suppl):1778-83. PMID: 18721942.
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    67. Thomas JC, Oottamasathien S, Makari JH, Honea L, Sharif-Afshar AR, Wang Y, Adams C, Wills ML, Bhowmick NA, Adams MC, Brock JW, Hayward SW, Matusik RJ, Pope JC. Temporal-spatial protein expression in bladder tissue derived from embryonic stem cells. J Urol. 2008 Oct; 180(4 Suppl):1784-9. PMID: 18721943.
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    68. Jin RJ, Lho Y, Connelly L, Wang Y, Yu X, Saint Jean L, Case TC, Ellwood-Yen K, Sawyers CL, Bhowmick NA, Blackwell TS, Yull FE, Matusik RJ. The nuclear factor-kappaB pathway controls the progression of prostate cancer to androgen-independent growth. Cancer Res. 2008 Aug 15; 68(16):6762-9. PMID: 18701501.
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    69. Erdogan M, Pozzi A, Bhowmick N, Moses HL, Zent R. Transforming growth factor-beta (TGF-beta) and TGF-beta-associated kinase 1 are required for R-Ras-mediated transformation of mammary epithelial cells. Cancer Res. 2008 Aug 01; 68(15):6224-31. PMID: 18676846.
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    70. Placencio VR, Sharif-Afshar AR, Li X, Huang H, Uwamariya C, Neilson EG, Shen MM, Matusik RJ, Hayward SW, Bhowmick NA. Stromal transforming growth factor-beta signaling mediates prostatic response to androgen ablation by paracrine Wnt activity. Cancer Res. 2008 Jun 15; 68(12):4709-18. PMID: 18559517.
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    71. Jackson RS, Franco OE, Bhowmick NA. Gene targeting to the stroma of the prostate and bone. Differentiation. 2008 Jul; 76(6):606-23. PMID: 18494814.
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    72. Starkman JS, Martinez-Ferrer M, Iturregui JM, Uwamariya C, Dmochowski RR, Bhowmick NA. Nicotinic signaling ameliorates acute bladder inflammation induced by protamine sulfate or cyclophosphamide. J Urol. 2008 Jun; 179(6):2440-6. PMID: 18433785.
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    73. Martinez-Ferrer M, Iturregui JM, Uwamariya C, Starkman J, Sharif-Afshar AR, Suzuki K, Visedsindh W, Matusik RJ, Dmochowski RR, Bhowmick NA. Role of nicotinic and estrogen signaling during experimental acute and chronic bladder inflammation. Am J Pathol. 2008 Jan; 172(1):59-67. PMID: 18079438.
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    74. Oottamasathien S, Williams K, Franco OE, Wills ML, Thomas JC, Sharif-Afshar AR, DeMarco RT, Brock JW, Bhowmick NA, Hayward SW, Pope JC. Urothelial inhibition of transforming growth factor-beta in a bladder tissue recombination model. J Urol. 2007 Oct; 178(4 Pt 2):1643-9. PMID: 17707033.
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    75. Erdogan M, Pozzi A, Bhowmick N, Moses HL, Zent R. Signaling pathways regulating TC21-induced tumorigenesis. J Biol Chem. 2007 Sep 21; 282(38):27713-20. PMID: 17656362.
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    76. Oottamasathien S, Wang Y, Williams K, Franco OE, Wills ML, Thomas JC, Saba K, Sharif-Afshar AR, Makari JH, Bhowmick NA, DeMarco RT, Hipkens S, Magnuson M, Brock JW, Hayward SW, Pope JC, Matusik RJ. Directed differentiation of embryonic stem cells into bladder tissue. Dev Biol. 2007 Apr 15; 304(2):556-66. PMID: 17289017.
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    77. M'Koma AE, Blum DL, Norris JL, Koyama T, Billheimer D, Motley S, Ghiassi M, Ferdowsi N, Bhowmick I, Chang SS, Fowke JH, Caprioli RM, Bhowmick NA. Detection of pre-neoplastic and neoplastic prostate disease by MALDI profiling of urine. Biochem Biophys Res Commun. 2007 Feb 16; 353(3):829-34. PMID: 17194448.
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    78. Oottamasathien S, Williams K, Franco OE, Thomas JC, Saba K, Bhowmick NA, Staack A, Demarco RT, Brock JW, Hayward SW, Pope JC. Bladder tissue formation from cultured bladder urothelium. Dev Dyn. 2006 Oct; 235(10):2795-801. PMID: 16804891.
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    79. Ao M, Williams K, Bhowmick NA, Hayward SW. Transforming growth factor-beta promotes invasion in tumorigenic but not in nontumorigenic human prostatic epithelial cells. Cancer Res. 2006 Aug 15; 66(16):8007-16. PMID: 16912176.
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    80. Wang W, Huang XR, Canlas E, Oka K, Truong LD, Deng C, Bhowmick NA, Ju W, Bottinger EP, Lan HY. Essential role of Smad3 in angiotensin II-induced vascular fibrosis. Circ Res. 2006 Apr 28; 98(8):1032-9. PMID: 16556868.
      View in: PubMed
    81. Sharif-Afshar AR, Donohoe JM, Pope JC, Adams MC, Brock JW, Bhowmick NA. Stromal hyperplasia in male bladders upon loss of transforming growth factor-beta signaling in fibroblasts. J Urol. 2005 Oct; 174(4 Pt 2):1704-7; discussion 1707. PMID: 16148686.
      View in: PubMed
    82. Cheng N, Bhowmick NA, Chytil A, Gorksa AE, Brown KA, Muraoka R, Arteaga CL, Neilson EG, Hayward SW, Moses HL. Loss of TGF-beta type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-alpha-, MSP- and HGF-mediated signaling networks. Oncogene. 2005 Jul 28; 24(32):5053-68. PMID: 15856015.
      View in: PubMed
    83. Bhowmick NA, Moses HL. Tumor-stroma interactions. Curr Opin Genet Dev. 2005 Feb; 15(1):97-101. PMID: 15661539.
      View in: PubMed
    84. Bhowmick NA, Neilson EG, Moses HL. Stromal fibroblasts in cancer initiation and progression. Nature. 2004 Nov 18; 432(7015):332-7. PMID: 15549095.
      View in: PubMed
    85. Brown K, Bhowmick NA. Linking TGF-beta-mediated Cdc25A inhibition and cytoskeletal regulation through RhoA/p160(ROCK) signaling. Cell Cycle. 2004 Apr; 3(4):408-10. PMID: 14752278.
      View in: PubMed
    86. Bhowmick NA, Chytil A, Plieth D, Gorska AE, Dumont N, Shappell S, Washington MK, Neilson EG, Moses HL. TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science. 2004 Feb 06; 303(5659):848-51. PMID: 14764882.
      View in: PubMed
    87. Bhowmick NA, Ghiassi M, Aakre M, Brown K, Singh V, Moses HL. TGF-beta-induced RhoA and p160ROCK activation is involved in the inhibition of Cdc25A with resultant cell-cycle arrest. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15548-53. PMID: 14657354.
      View in: PubMed
    88. Gorska AE, Jensen RA, Shyr Y, Aakre ME, Bhowmick NA, Moses HL. Transgenic mice expressing a dominant-negative mutant type II transforming growth factor-beta receptor exhibit impaired mammary development and enhanced mammary tumor formation. Am J Pathol. 2003 Oct; 163(4):1539-49. PMID: 14507660.
      View in: PubMed
    89. Xie L, Law BK, Aakre ME, Edgerton M, Shyr Y, Bhowmick NA, Moses HL. Transforming growth factor beta-regulated gene expression in a mouse mammary gland epithelial cell line. Breast Cancer Res. 2003; 5(6):R187-98. PMID: 14580254.
      View in: PubMed
    90. Tu WH, Thomas TZ, Masumori N, Bhowmick NA, Gorska AE, Shyr Y, Kasper S, Case T, Roberts RL, Shappell SB, Moses HL, Matusik RJ. The loss of TGF-beta signaling promotes prostate cancer metastasis. Neoplasia. 2003 May-Jun; 5(3):267-77. PMID: 12869309.
      View in: PubMed
    91. Bhowmick NA, Zent R, Ghiassi M, McDonnell M, Moses HL. Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity. J Biol Chem. 2001 Dec 14; 276(50):46707-13. PMID: 11590169.
      View in: PubMed
    92. Bhowmick NA, Ghiassi M, Bakin A, Aakre M, Lundquist CA, Engel ME, Arteaga CL, Moses HL. Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Mol Biol Cell. 2001 Jan; 12(1):27-36. PMID: 11160820.
      View in: PubMed
    93. Bakin AV, Tomlinson AK, Bhowmick NA, Moses HL, Arteaga CL. Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration. J Biol Chem. 2000 Nov 24; 275(47):36803-10. PMID: 10969078.
      View in: PubMed
    94. Bhowmick N, Narayan P, Puett D. Identification of ionizable amino acid residues on the extracellular domain of the lutropin receptor involved in ligand binding. Endocrinology. 1999 Oct; 140(10):4558-63. PMID: 10499511.
      View in: PubMed
    95. Bhowmick N, Narayan P, Puett D. The endothelin subtype A receptor undergoes agonist- and antagonist-mediated internalization in the absence of signaling. Endocrinology. 1998 Jul; 139(7):3185-92. PMID: 9645692.
      View in: PubMed
    96. Puett D, Bhowmick N, Fernandez LM, Huang J, Wu C, Narayan P. hCG-receptor binding and transmembrane signaling. Mol Cell Endocrinol. 1996 Dec 20; 125(1-2):55-64. PMID: 9027343.
      View in: PubMed
    97. Bhowmick N, Huang J, Puett D, Isaacs NW, Lapthorn AJ. Determination of residues important in hormone binding to the extracellular domain of the luteinizing hormone/chorionic gonadotropin receptor by site-directed mutagenesis and modeling. Mol Endocrinol. 1996 Sep; 10(9):1147-59. PMID: 8885249.
      View in: PubMed