Mouad Edderkaoui

Title(s)Adjunct Professor, Medicine
SchoolMedicine
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    1. Stromal softness confines pancreatic cancer growth through lysosomal-cathepsin mediated YAP1 degradation. Cell Mol Life Sci. 2024 Oct 26; 81(1):442. Zhang T, Chen J, Yang H, Sun X, Ou Y, Wang Q, Edderkaoui M, Zheng S, Ren F, Tong Y, Hu R, Liu J, Gao Y, Pandol SJ, Han YP, Zheng X. PMID: 39460766; PMCID: PMC11512982.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Unraveling the hepatoprotective and anti-pancreatic cancer potential of Caralluma europaea: a comprehensive in vivo, in vitro and in silico evidence. Drug Chem Toxicol. 2024 Oct 17; 1-16. Amrati FE, Lim A, Slighoua M, Chebaibi M, Mssillou I, Drioiche A, Di Cristo F, Al-Sheikh YA, Aboul-Soud MAM, Edderkaoui M, Bousta D. PMID: 39415714.
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    3. Metavert synergises with standard cytotoxics in human PDAC organoids and is associated with transcriptomic signatures of therapeutic response. Transl Oncol. 2024 Nov; 49:102109. An J, Kurilov R, Peccerella T, Bergmann F, Edderkaoui M, Lim A, Zhou X, Pfütze K, Schulz A, Wolf S, Hu K, Springfeld C, Mughal SS, Zezlina L, Fortunato F, Beyer G, Mayerle J, Roth S, Hulkkonen J, Merz D, Ei S, Mehrabi A, Loos M, Al-Saeedi M, Michalski CW, Büchler MW, Hackert T, Brors B, Pandol SJ, Bailey P, Neoptolemos JP. PMID: 39217851; PMCID: PMC11402625.
      View in: PubMed   Mentions:
    4. Promoter Methylation Leads to Hepatocyte Nuclear Factor 4A Loss and Pancreatic Cancer Aggressiveness. Gastro Hep Adv. 2024; 3(5):687-702. Hatziapostolou M, Koutsioumpa M, Zaitoun AM, Polytarchou C, Edderkaoui M, Mahurkar-Joshi S, Vadakekolathu J, D'Andrea D, Lay AR, Christodoulou N, Pham T, Yau TO, Vorvis C, Chatterji S, Pandol SJ, Poultsides GA, Dawson DW, Lobo DN, Iliopoulos D. PMID: 39165427; PMCID: PMC11330932.
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    5. Designing a predictive Framework: Immune-Related Gene-Based nomogram and prognostic model for kidney renal papillary cell carcinoma. Int Immunopharmacol. 2024 Apr 20; 131:111878. Lim A, Edderkaoui M, Zhang Y, Wang Q, Wang R, Pandol SJ, Ou Y. PMID: 38493693.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Spontaneous Fusion with Transformed Mesenchymal Stromal Cells Results in Complete Heterogeneity in Prostate Cancer Cells. Cancers (Basel). 2024 Feb 27; 16(5). Wang R, Hu P, Wang F, Lyu J, Ou Y, Edderkaoui M, Zhang Y, Lewis MS, Pandol SJ, Zhau HE, Chung LWK. PMID: 38473313; PMCID: PMC10931070.
      View in: PubMed   Mentions:
    7. Overcoming Resistance in Prostate Cancer Therapy Using a DZ-Simvastatin Conjugate. Mol Pharm. 2024 Feb 05; 21(2):873-882. Ou Y, Chu GC, Lyu J, Yin L, Lim A, Zhai N, Cui X, Lewis MS, Edderkaoui M, Pandol SJ, Wang R, Zhang Y. PMID: 38229228; PMCID: PMC11025579.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. Verteporfin induces lipid peroxidation and ferroptosis in pancreatic cancer cells. Free Radic Biol Med. 2024 02 20; 212:493-504. Zhou W, Lim A, Elmadbouh OHM, Edderkaoui M, Osipov A, Mathison AJ, Urrutia R, Liu T, Wang Q, Pandol SJ. PMID: 38184120; PMCID: PMC10906657.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    9. Role of YAP Signaling in Regulation of Programmed Cell Death and Drug Resistance in Cancer. Int J Biol Sci. 2024; 20(1):15-28. Zhou W, Lim A, Edderkaoui M, Osipov A, Wu H, Wang Q, Pandol S. PMID: 38164167; PMCID: PMC10750275.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    10. Supraphysiological glutamine as a means of depleting intracellular amino acids to enhance pancreatic cancer chemosensitivity. Res Sq. 2023 Nov 30. Muranaka H, Billet S, Cruz-Hernández C, Ten Hoeve J, Gonzales G, Elmadbouh O, Zhang L, Smith B, Tighiouart M, You S, Edderkaoui M, Hendifar A, Pandol S, Gong J, Bhowmick N. PMID: 38076821; PMCID: PMC10705710.
      View in: PubMed   Mentions:
    11. A cisplatin conjugate with tumor cell specificity exhibits antitumor effects in renal cancer models. BMC Cancer. 2023 Jun 02; 23(1):499. Mrdenovic S, Wang Y, Yin L, Chu GC, Ou Y, Lewis MS, Heffer M, Posadas EM, Zhau HE, Chung LWK, Edderkaoui M, Pandol SJ, Wang R, Zhang Y. PMID: 37268911; PMCID: PMC10236852.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    12. An Update on Tamoxifen and the Chemo-Preventive Potential of Vitamin E in Breast Cancer Management. J Pers Med. 2023 Apr 28; 13(5). Khallouki F, Hajji L, Saber S, Bouddine T, Edderkaoui M, Bourhia M, Mir N, Lim A, El Midaoui A, Giesy JP, Aboul-Soud MAM, Silvente-Poirot S, Poirot M. PMID: 37240924; PMCID: PMC10221210.
      View in: PubMed   Mentions: 3  
    13. Glycogen Synthase Kinase 3β: A True Foe in Pancreatic Cancer. Int J Mol Sci. 2022 Nov 16; 23(22). Elmadbouh OHM, Pandol SJ, Edderkaoui M. PMID: 36430630; PMCID: PMC9696080.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    14. Evaluation of the toxicity of Caralluma europaea (C.E) extracts and their effects on apoptosis and chemoresistance in pancreatic cancer cells. J Biomol Struct Dyn. 2023 Oct-Nov; 41(17):8517-8534. Amrati FE, Elmadbouh OHM, Chebaibi M, Soufi B, Conte R, Slighoua M, Saleh A, Al Kamaly O, Drioiche A, Zair T, Edderkaoui M, Bousta D. PMID: 36271642.
      View in: PubMed   Mentions: 9     Fields:    
    15. Novel DZ-SIM Conjugate Targets Cancer Mitochondria and Prolongs Survival in Pancreatic Ductal Adenocarcinoma. Adv Ther (Weinh). 2022 Oct; 5(10). Ou Y, Wang R, Chu GC, Elmadbouh OHM, Lim A, Chung LW, Edderkaoui M, Zhang Y, Pandol SJ. PMID: 36590644; PMCID: PMC9797106.
      View in: PubMed   Mentions:
    16. Sequestration of Intestinal Acidic Toxins by Cationic Resin Attenuates Pancreatic Cancer Progression through Promoting Autophagic Flux for YAP Degradation. Cancers (Basel). 2022 Mar 10; 14(6). Zhao G, Zhang T, Liu W, Edderkaoui M, Hu R, Li J, Pandol SJ, Fu X, Han YP. PMID: 35326559; PMCID: PMC8946475.
      View in: PubMed   Mentions: 3  
    17. HDAC4 Mediates Smoking-Induced Pancreatic Cancer Metastasis. Pancreas. 2022 02 01; 51(2):190-195. Yang J, Chheda C, Lim A, Hauptschein D, Zayou L, Tang J, Pandol SJ, Edderkaoui M. PMID: 35404896; PMCID: PMC9004243.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    18. Co-Variation of Serum Osteoprotegerin and Pigment-Epithelial Derived Factor as Biomarker of Pancreatic Cancer. Austin J Gastroenterol. 2022; 9(1). Edderkaoui M, Chheda C, Lim A, Pandol SJ, Murali R. PMID: 35571223; PMCID: PMC9104202.
      View in: PubMed   Mentions: 2  
    19. Dual targeting of GSK3B and HDACs reduces tumor growth and improves survival in an ovarian cancer mouse model. Gynecol Oncol. 2020 10; 159(1):277-284. Taylan E, Zayou F, Murali R, Karlan BY, Pandol SJ, Edderkaoui M, Orsulic S. PMID: 32698955; PMCID: PMC7769125.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    20. Animal Models: Challenges and Opportunities to Determine Optimal Experimental Models of Pancreatitis and Pancreatic Cancer. Pancreas. 2019 07; 48(6):759-779. Saloman JL, Albers KM, Cruz-Monserrate Z, Davis BM, Edderkaoui M, Eibl G, Epouhe AY, Gedeon JY, Gorelick FS, Grippo PJ, Groblewski GE, Husain SZ, Lai KKY, Pandol SJ, Uc A, Wen L, Whitcomb DC. PMID: 31206467; PMCID: PMC6581211.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    21. MSP-RON Signaling Is Activated in the Transition From Pancreatic Intraepithelial Neoplasia (PanIN) to Pancreatic Ductal Adenocarcinoma (PDAC). Front Physiol. 2019; 10:147. Li C, Morvaridi S, Lam G, Chheda C, Kamata Y, Katsumata M, Edderkaoui M, Yuan X, Nissen N, Pandol SJ, Wang Q. PMID: 30863319; PMCID: PMC6399467.
      View in: PubMed   Mentions: 11  
    22. An Inhibitor of GSK3B and HDACs Kills Pancreatic Cancer Cells and Slows Pancreatic Tumor Growth and Metastasis in Mice. Gastroenterology. 2018 12; 155(6):1985-1998.e5. Edderkaoui M, Chheda C, Soufi B, Zayou F, Hu RW, Ramanujan VK, Pan X, Boros LG, Tajbakhsh J, Madhav A, Bhowmick NA, Wang Q, Lewis M, Tuli R, Habtezion A, Murali R, Pandol SJ. PMID: 30144430; PMCID: PMC6328046.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    23. Tobacco and alcohol as risk factors for pancreatic cancer. Best Pract Res Clin Gastroenterol. 2017 Oct; 31(5):529-536. Korc M, Jeon CY, Edderkaoui M, Pandol SJ, Petrov MS, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC). PMID: 29195672; PMCID: PMC5747325.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals
    24. The Potential for Circulating Tumor Cells in Pancreatic Cancer Management. Front Physiol. 2017; 8:381. Pimienta M, Edderkaoui M, Wang R, Pandol S. PMID: 28626429; PMCID: PMC5454071.
      View in: PubMed   Mentions: 21  
    25. Cadherin-11 Is a Cell Surface Marker Up-Regulated in Activated Pancreatic Stellate Cells and Is Involved in Pancreatic Cancer Cell Migration. Am J Pathol. 2017 Jan; 187(1):146-155. Birtolo C, Pham H, Morvaridi S, Chheda C, Go VL, Ptasznik A, Edderkaoui M, Weisman MH, Noss E, Brenner MB, Larson B, Guindi M, Wang Q, Pandol SJ. PMID: 27855278; PMCID: PMC5225304.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    26. Aryl Hydrocarbon Receptor Ligands in Cigarette Smoke Induce Production of Interleukin-22 to Promote Pancreatic Fibrosis in Models of Chronic Pancreatitis. Gastroenterology. 2016 12; 151(6):1206-1217. Xue J, Zhao Q, Sharma V, Nguyen LP, Lee YN, Pham KL, Edderkaoui M, Pandol SJ, Park W, Habtezion A. PMID: 27769811; PMCID: PMC5499510.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    27. HDAC3 mediates smoking-induced pancreatic cancer. Oncotarget. 2016 Feb 16; 7(7):7747-60. Edderkaoui M, Xu S, Chheda C, Morvaridi S, Hu RW, Grippo PJ, Mascariñas E, Principe DR, Knudsen B, Xue J, Habtezion A, Uyeminami D, Pinkerton KE, Pandol SJ. PMID: 26745602; PMCID: PMC4884951.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    28. Macrophages and pancreatic ductal adenocarcinoma. Cancer Lett. 2016 10 10; 381(1):211-6. Habtezion A, Edderkaoui M, Pandol SJ. PMID: 26708507; PMCID: PMC4912945.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    29. Characterization of Mouse Models of Early Pancreatic Lesions Induced by Alcohol and Chronic Pancreatitis. Pancreas. 2015 Aug; 44(6):882-7. Xu S, Chheda C, Ouhaddi Y, Benhaddou H, Bourhim M, Grippo PJ, Principe DR, Mascariñas E, DeCant B, Tsukamoto H, Pandol SJ, Edderkaoui M. PMID: 26166469; PMCID: PMC4503385.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    30. What are the macrophages and stellate cells doing in pancreatic adenocarcinoma? Front Physiol. 2015; 6:125. Pandol SJ, Edderkaoui M. PMID: 26029109; PMCID: PMC4432577.
      View in: PubMed   Mentions: 7  
    31. Risk factors for pancreatic cancer: underlying mechanisms and potential targets. Front Physiol. 2014; 5:490. Edderkaoui M, Eibl G. PMID: 25540626; PMCID: PMC4261721.
      View in: PubMed   Mentions: 2  
    32. NADPH oxidase activation in pancreatic cancer cells is mediated through Akt-dependent up-regulation of p22phox. J Biol Chem. 2013 Dec 20; 288(51):36259. Edderkaoui M, Nitsche C, Zheng L, Pandol SJ, Gukovsky I, Gukovskaya AS. PMID: 24363267; PMCID: PMC3868740.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    33. Smoking and Pancreatic Disease. J Cancer Ther. 2013 Nov 01; 4(10A):34-40. Edderkaoui M, Thrower E. PMID: 24660091; PMCID: PMC3961826.
      View in: PubMed   Mentions: 21  
    34. Ellagic acid and embelin affect key cellular components of pancreatic adenocarcinoma, cancer, and stellate cells. Nutr Cancer. 2013; 65(8):1232-44. Edderkaoui M, Lugea A, Hui H, Eibl G, Lu QY, Moro A, Lu X, Li G, Go VL, Pandol SJ. PMID: 24127740; PMCID: PMC3909533.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    35. Akt kinase mediates the prosurvival effect of smoking compounds in pancreatic ductal cells. Pancreas. 2013 May; 42(4):655-62. Park CH, Lee IS, Grippo P, Pandol SJ, Gukovskaya AS, Edderkaoui M. PMID: 23271397; PMCID: PMC4085048.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    36. Determination of Rottlerin, a Natural Protein Kinases C Inhibitor, in Pancreatic Cancer Cells and Mouse Xenografts by RP-HPLC Method. J Chromatogr Sep Tech. 2013 Jan 01; 4(1). Lu QY, Zhang L, Lugea A, Moro A, Edderkaoui M, Eibl G, Pandol SJ, Go VL. PMID: 24482742; PMCID: PMC3904376.
      View in: PubMed   Mentions: 9  
    37. The burning question: why is smoking a risk factor for pancreatic cancer? Pancreatology. 2012 Jul-Aug; 12(4):344-9. Pandol SJ, Apte MV, Wilson JS, Gukovskaya AS, Edderkaoui M. PMID: 22898636; PMCID: PMC3956306.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    38. Molecular basis for the interplay of apoptosis and proliferation mediated by Bcl-xL:Bim interactions in pancreatic cancer cells. Biochem Biophys Res Commun. 2012 Jun 15; 422(4):596-601. Abrol R, Edderkaoui M, Goddard WA, Pandol SJ. PMID: 22609401; PMCID: PMC4620986.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    39. Epidemiology, risk factors, and the promotion of pancreatic cancer: role of the stellate cell. J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:127-34. Pandol S, Gukovskaya A, Edderkaoui M, Edderkoui M, Dawson D, Eibl G, Lugea A. PMID: 22320930; PMCID: PMC3736749.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    40. The phosphatase PHLPP1 regulates Akt2, promotes pancreatic cancer cell death, and inhibits tumor formation. Gastroenterology. 2012 Feb; 142(2):377-87.e1-5. Nitsche C, Edderkaoui M, Moore RM, Eibl G, Kasahara N, Treger J, Grippo PJ, Mayerle J, Lerch MM, Gukovskaya AS. PMID: 22044669; PMCID: PMC4545256.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    41. NADPH oxidase activation in pancreatic cancer cells is mediated through Akt-dependent up-regulation of p22phox. J Biol Chem. 2011 03 11; 286(10):7779-7787. Edderkaoui M, Nitsche C, Zheng L, Pandol SJ, Gukovsky I, Gukovskaya AS. PMID: 21118808; PMCID: PMC3048665.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    42. Desmoplasia of pancreatic ductal adenocarcinoma. Clin Gastroenterol Hepatol. 2009 Nov; 7(11 Suppl):S44-7. Pandol S, Edderkaoui M, Gukovsky I, Lugea A, Gukovskaya A. PMID: 19896098; PMCID: PMC4573641.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansCells
    43. Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family. Am J Physiol Gastrointest Liver Physiol. 2010 Jan; 298(1):G63-73. Ohno I, Eibl G, Odinokova I, Edderkaoui M, Damoiseaux RD, Yazbec M, Abrol R, Goddard WA, Yokosuka O, Pandol SJ, Gukovskaya AS. PMID: 19762431; PMCID: PMC2806098.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    44. Protein kinase D1 mediates NF-kappaB activation induced by cholecystokinin and cholinergic signaling in pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol. 2008 Dec; 295(6):G1190-201. Yuan J, Lugea A, Zheng L, Gukovsky I, Edderkaoui M, Rozengurt E, Pandol SJ. PMID: 18845574; PMCID: PMC2604803.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    45. Ellagic acid induces apoptosis through inhibition of nuclear factor kappa B in pancreatic cancer cells. World J Gastroenterol. 2008 Jun 21; 14(23):3672-80. Edderkaoui M, Odinokova I, Ohno I, Gukovsky I, Go VL, Pandol SJ, Gukovskaya AS. PMID: 18595134; PMCID: PMC2719230.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    46. NADPH oxidase promotes pancreatic cancer cell survival via inhibiting JAK2 dephosphorylation by tyrosine phosphatases. Gastroenterology. 2007 Nov; 133(5):1637-48. Lee JK, Edderkaoui M, Truong P, Ohno I, Jang KT, Berti A, Pandol SJ, Gukovskaya AS. PMID: 17983808.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
    47. Insulin-like growth factor-I receptor mediates the prosurvival effect of fibronectin. J Biol Chem. 2007 Sep 14; 282(37):26646-26655. Edderkaoui M, Hong P, Lee JK, Pandol SJ, Gukovskaya AS. PMID: 17627944.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    48. Ethanol augments PDGF-induced NADPH oxidase activity and proliferation in rat pancreatic stellate cells. Pancreatology. 2007; 7(4):332-40. Hu R, Wang YL, Edderkaoui M, Lugea A, Apte MV, Pandol SJ. PMID: 17627098; PMCID: PMC2826430.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    49. Tumor necrosis factor-alpha mediates pancreatitis responses in acinar cells via protein kinase C and proline-rich tyrosine kinase 2. Gastroenterology. 2005 Aug; 129(2):639-51. Satoh A, Gukovskaya AS, Edderkaoui M, Daghighian MS, Reeve JR, Shimosegawa T, Pandol SJ. PMID: 16083718.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    50. Extracellular matrix stimulates reactive oxygen species production and increases pancreatic cancer cell survival through 5-lipoxygenase and NADPH oxidase. Am J Physiol Gastrointest Liver Physiol. 2005 Dec; 289(6):G1137-47. Edderkaoui M, Hong P, Vaquero EC, Lee JK, Fischer L, Friess H, Buchler MW, Lerch MM, Pandol SJ, Gukovskaya AS. PMID: 16037546.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    51. Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells. J Biol Chem. 2004 Aug 13; 279(33):34643-54. Vaquero EC, Edderkaoui M, Pandol SJ, Gukovsky I, Gukovskaya AS. PMID: 15155719.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansCells
    52. Extracellular matrix proteins protect pancreatic cancer cells from death via mitochondrial and nonmitochondrial pathways. Gastroenterology. 2003 Oct; 125(4):1188-202. Vaquero EC, Edderkaoui M, Nam KJ, Gukovsky I, Pandol SJ, Gukovskaya AS. PMID: 14517801.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
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