Anna S Gukovskaya

Title(s)Professor-in-Residence, Medicine
SchoolMedicine
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    Collapse Research 
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    Cell Death and Autophagy in Chronic Pancreatitis
    NIH I01BX004306Jul 1, 2018 - Jun 30, 2022
    Role: Principal Investigator
    Organelle Disorders in Pancreatitis
    NIH P01DK098108Sep 1, 2014 - Jun 30, 2021
    Role: Principal Investigator
    Mitochondrial Dysfunction, Permeability Transition Pore, and Acute Pancreatitis
    NIH I01BX000774Oct 1, 2010 - Sep 30, 2014
    Role: Principal Investigator
    NADPH oxidase and pancreatic cancer cell survival
    NIH R01CA119025Sep 5, 2006 - Jul 31, 2011
    Role: Principal Investigator
    Apoptosis and Necrosis in Pancreatitis
    NIH R01DK059936Jul 1, 2001 - Mar 31, 2015
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Trypsin in pancreatitis: The culprit, a mediator, or epiphenomenon? World J Gastroenterol. 2024 Nov 07; 30(41):4417-4438. Gukovskaya AS, Lerch MM, Mayerle J, Sendler M, Ji B, Saluja AK, Gorelick FS, Gukovsky I. PMID: 39534420; PMCID: PMC11551668.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Ethanol inhibits pancreatic acinar cell autophagy through upregulation of ATG4B, mediating pathological responses of alcoholic pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2023 09 01; 325(3):G265-G278. Mareninova OA, Gretler SR, Lee GE, Pimienta M, Qin Y, Elperin JM, Ni J, Razga Z, Gukovskaya AS, Gukovsky I. PMID: 37431575; PMCID: PMC10511161.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    3. Rab9 Mediates Pancreatic Autophagy Switch From Canonical to Noncanonical, Aggravating Experimental Pancreatitis. Cell Mol Gastroenterol Hepatol. 2022; 13(2):599-622. Mareninova OA, Dillon DL, Wightman CJM, Yakubov I, Takahashi T, Gaisano HY, Munson K, Ohmuraya M, Dawson D, Gukovsky I, Gukovskaya AS. PMID: 34610499; PMCID: PMC8715155.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    4. Dysregulation of mannose-6-phosphate-dependent cholesterol homeostasis in acinar cells mediates pancreatitis. J Clin Invest. 2021 08 02; 131(15). Mareninova OA, Vegh ET, Shalbueva N, Wightman CJ, Dillon DL, Malla S, Xie Y, Takahashi T, Rakonczay Z, French SW, Gaisano HY, Gorelick FS, Pandol SJ, Bensinger SJ, Davidson NO, Dawson DW, Gukovsky I, Gukovskaya AS. PMID: 34128834; PMCID: PMC8321573.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    5. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021 Jan; 17(1):1-382. Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Álvarez ÉMC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R, Avagliano L, Ávalos Y, Aveic S, Aveleira CA, Avin-Wittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer JM, Backues SK, Bae DH, Bae ON, Bae SH, Baehrecke EH, Baek A, Baek SH, Baek SH, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari CT, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Banerjee S, Bánréti Á, Bao Y, Baptista MS, Baracca A, Barbati C, Bargiela A, Barilà D, Barlow PG, Barmada SJ, Barreiro E, Barreto GE, Bartek J, Bartel B, Bartolome A, Barve GR, Basagoudanavar SH, Bassham DC, Bast RC, Basu A, Batoko H, Batten I, Baulieu EE, Baumgarner BL, Bayry J, Beale R, Beau I, Beaumatin F, Bechara LRG, Beck GR, Beers MF, Begun J, Behrends C, Behrens GMN, Bei R, Bejarano E, Bel S, Behl C, Belaid A, Belgareh-Touzé N, Bellarosa C, Belleudi F, Belló Pérez M, Bello-Morales R, Beltran JSO, Beltran S, Benbrook DM, Bendorius M, Benitez BA, Benito-Cuesta I, Bensalem J, Berchtold MW, Berezowska S, Bergamaschi D, Bergami M, Bergmann A, Berliocchi L, Berlioz-Torrent C, Bernard A, Berthoux L, Besirli CG, Besteiro S, Betin VM, Beyaert R, Bezbradica JS, Bhaskar K, Bhatia-Kissova I, Bhattacharya R, Bhattacharya S, Bhattacharyya S, Bhuiyan MS, Bhutia SK, Bi L, Bi X, Biden TJ, Bijian K, Billes VA, Binart N, Bincoletto C, Birgisdottir AB, Bjorkoy G, Blanco G, Blas-Garcia A, Blasiak J, Blomgran R, Blomgren K, Blum JS, Boada-Romero E, Boban M, Boesze-Battaglia K, Boeuf P, Boland B, Bomont P, Bonaldo P, Bonam SR, Bonfili L, Bonifacino JS, Boone BA, Bootman MD, Bordi M, Borner C, Bornhauser BC, Borthakur G, Bosch J, Bose S, Botana LM, Botas J, Boulanger CM, Boulton ME, Bourdenx M, Bourgeois B, Bourke NM, Bousquet G, Boya P, Bozhkov PV, Bozi LHM, Bozkurt TO, Brackney DE, Brandts CH, Braun RJ, Braus GH, Bravo-Sagua R, Bravo-San Pedro JM, Brest P, Bringer MA, Briones-Herrera A, Broaddus VC, Brodersen P, Brodsky JL, Brody SL, Bronson PG, Bronstein JM, Brown CN, Brown RE, Brum PC, Brumell JH, Brunetti-Pierri N, Bruno D, Bryson-Richardson RJ, Bucci C, Buchrieser C, Bueno M, Buitrago-Molina LE, Buraschi S, Buch S, Buchan JR, Buckingham EM, Budak H, Budini M, Bultynck G, Burada F, Burgoyne JR, Burón MI, Bustos V, Büttner S, Butturini E, Byrd A, Cabas I, Cabrera-Benitez S, Cadwell K, Cai J, Cai L, Cai Q, Cairó M, Calbet JA, Caldwell GA, Caldwell KA, Call JA, Calvani R, Calvo AC, Calvo-Rubio Barrera M, Camara NO, Camonis JH, Camougrand N, Campanella M, Campbell EM, Campbell-Valois FX, Campello S, Campesi I, Campos JC, et al. PMID: 33634751; PMCID: PMC7996087.
      View in: PubMed   Mentions: 1060     Fields:    Translation:HumansAnimalsCells
    6. Critical thresholds: key to unlocking the door to the prevention and specific treatments for acute pancreatitis. Gut. 2021 01; 70(1):194-203. Barreto SG, Habtezion A, Gukovskaya A, Lugea A, Jeon C, Yadav D, Hegyi P, Venglovecz V, Sutton R, Pandol SJ. PMID: 32973069; PMCID: PMC7816970.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    7. American Pancreatic Association Frank Brooks Symposium: Fifty Years of Pancreatic Cell Biology. Pancreas. 2020 May/Jun; 49(5):604-611. Williams JA, Groblewski GE, Gorelick FS, Mayerle J, Apte M, Gukovskaya AS. PMID: 32433396; PMCID: PMC7249997.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Transgenic expression of GFP-LC3 perturbs autophagy in exocrine pancreas and acute pancreatitis responses in mice. Autophagy. 2020 11; 16(11):2084-2097. Mareninova OA, Jia W, Gretler SR, Holthaus CL, Thomas DDH, Pimienta M, Dillon DL, Gukovskaya AS, Gukovsky I, Groblewski GE. PMID: 31942816; PMCID: PMC7595606.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    9. Early trypsin activation develops independently of autophagy in caerulein-induced pancreatitis in mice. Cell Mol Life Sci. 2020 May; 77(9):1811-1825. Malla SR, Krueger B, Wartmann T, Sendler M, Mahajan UM, Weiss FU, Thiel FG, De Boni C, Gorelick FS, Halangk W, Aghdassi AA, Reinheckel T, Gukovskaya AS, Lerch MM, Mayerle J. PMID: 31363815; PMCID: PMC8221268.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    10. Recent Insights Into the Pathogenic Mechanism of Pancreatitis: Role of Acinar Cell Organelle Disorders. Pancreas. 2019 04; 48(4):459-470. Gukovskaya AS, Gorelick FS, Groblewski GE, Mareninova OA, Lugea A, Antonucci L, Waldron RT, Habtezion A, Karin M, Pandol SJ, Gukovsky I. PMID: 30973461; PMCID: PMC6461375.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    11. Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis. Autophagy. 2019 11; 15(11):1954-1969. Wang S, Ni HM, Chao X, Wang H, Bridges B, Kumer S, Schmitt T, Mareninova O, Gukovskaya A, De Lisle RC, Ballabio A, Pacher P, Ding WX. PMID: 30894069; PMCID: PMC6844531.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    12. Acute Pancreatitis: A Multifaceted Set of Organelle and Cellular Interactions. Gastroenterology. 2019 05; 156(7):1941-1950. Habtezion A, Gukovskaya AS, Pandol SJ. PMID: 30660726; PMCID: PMC6613790.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    13. Accelerating the Drug Delivery Pipeline for Acute and Chronic Pancreatitis: Summary of the Working Group on Drug Development and Trials in Acute Pancreatitis at the National Institute of Diabetes and Digestive and Kidney Diseases Workshop. Pancreas. 2018 Nov/Dec; 47(10):1185-1192. Abu-El-Haija M, Gukovskaya AS, Andersen DK, Gardner TB, Hegyi P, Pandol SJ, Papachristou GI, Saluja AK, Singh VK, Uc A, Wu BU. PMID: 30325856; PMCID: PMC6692135.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    14. Cathepsin B-Mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice. Gastroenterology. 2018 02; 154(3):704-718.e10. Sendler M, Weiss FU, Golchert J, Homuth G, van den Brandt C, Mahajan UM, Partecke LI, Döring P, Gukovsky I, Gukovskaya AS, Wagh PR, Lerch MM, Mayerle J. PMID: 29079517; PMCID: PMC6663074.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCells
    15. Mitochondrial Dysfunction, Through Impaired Autophagy, Leads to Endoplasmic Reticulum Stress, Deregulated Lipid Metabolism, and Pancreatitis in Animal Models. Gastroenterology. 2018 Feb; 154(3):689-703. Biczo G, Vegh ET, Shalbueva N, Mareninova OA, Elperin J, Lotshaw E, Gretler S, Lugea A, Malla SR, Dawson D, Ruchala P, Whitelegge J, French SW, Wen L, Husain SZ, Gorelick FS, Hegyi P, Rakonczay Z, Gukovsky I, Gukovskaya AS. PMID: 29074451; PMCID: PMC6369139.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansAnimalsCells
    16. Human Pancreatic Acinar Cells: Proteomic Characterization, Physiologic Responses, and Organellar Disorders in ex Vivo Pancreatitis. Am J Pathol. 2017 Dec; 187(12):2726-2743. Lugea A, Waldron RT, Mareninova OA, Shalbueva N, Deng N, Su HY, Thomas DD, Jones EK, Messenger SW, Yang J, Hu C, Gukovsky I, Liu Z, Groblewski GE, Gukovskaya AS, Gorelick FS, Pandol SJ. PMID: 28935577; PMCID: PMC5718097.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    17. Autophagy, Inflammation, and Immune Dysfunction in the Pathogenesis of Pancreatitis. Gastroenterology. 2017 11; 153(5):1212-1226. Gukovskaya AS, Gukovsky I, Algül H, Habtezion A. PMID: 28918190; PMCID: PMC6338477.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansAnimalsCells
    18. Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice. PLoS One. 2017; 12(9):e0184455. Chang HH, Moro A, Takakura K, Su HY, Mo A, Nakanishi M, Waldron RT, French SW, Dawson DW, Hines OJ, Li G, Go VLW, Sinnett-Smith J, Pandol SJ, Lugea A, Gukovskaya AS, Duff MO, Rosenberg DW, Rozengurt E, Eibl G. PMID: 28886117; PMCID: PMC5590955.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    19. Roles of autophagy and metabolism in pancreatic cancer cell adaptation to environmental challenges. Am J Physiol Gastrointest Liver Physiol. 2017 Nov 01; 313(5):G524-G536. Maertin S, Elperin JM, Lotshaw E, Sendler M, Speakman SD, Takakura K, Reicher BM, Mareninova OA, Grippo PJ, Mayerle J, Lerch MM, Gukovskaya AS. PMID: 28705806; PMCID: PMC5792215.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    20. Acute acinar pancreatitis blocks vesicle-associated membrane protein 8 (VAMP8)-dependent secretion, resulting in intracellular trypsin accumulation. J Biol Chem. 2017 05 12; 292(19):7828-7839. Messenger SW, Jones EK, Holthaus CL, Thomas DDH, Cooley MM, Byrne JA, Mareninova OA, Gukovskaya AS, Groblewski GE. PMID: 28242757; PMCID: PMC5427264.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    21. Analysis of N- and O-Glycosylation of Lysosomal Glycoproteins. Methods Mol Biol. 2017; 1594:35-42. Tokhtaeva E, Mareninova OA, Gukovskaya AS, Vagin O. PMID: 28456975; PMCID: PMC6663072.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    22. Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome. Sci Rep. 2016 11 15; 6:37200. Sakata K, Araki K, Nakano H, Nishina T, Komazawa-Sakon S, Murai S, Lee GE, Hashimoto D, Suzuki C, Uchiyama Y, Notohara K, Gukovskaya AS, Gukovsky I, Yamamura KI, Baba H, Ohmuraya M. PMID: 27845447; PMCID: PMC5109027.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    23. New insights into the pathways initiating and driving pancreatitis. Curr Opin Gastroenterol. 2016 Sep; 32(5):429-435. Gukovskaya AS, Pandol SJ, Gukovsky I. PMID: 27428704; PMCID: PMC5235997.
      View in: PubMed   Mentions: 33     Fields:    
    24. Lysosome associated membrane proteins maintain pancreatic acinar cell homeostasis: LAMP-2 deficient mice develop pancreatitis. Cell Mol Gastroenterol Hepatol. 2015 Nov 01; 1(6):678-694. Mareninova OA, Sendler M, Malla SR, Yakubov I, French SW, Tokhtaeva E, Vagin O, Oorschot V, Lüllmann-Rauch R, Blanz J, Dawson D, Klumperman J, Lerch MM, Mayerle J, Gukovsky I, Gukovskaya AS. PMID: 26693174; PMCID: PMC4673685.
      View in: PubMed   Mentions: 70     Fields:    
    25. Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP. Gut. 2016 08; 65(8):1333-46. Mukherjee R, Mareninova OA, Odinokova IV, Huang W, Murphy J, Chvanov M, Javed MA, Wen L, Booth DM, Cane MC, Awais M, Gavillet B, Pruss RM, Schaller S, Molkentin JD, Tepikin AV, Petersen OH, Pandol SJ, Gukovsky I, Criddle DN, Gukovskaya AS, Sutton R, NIHR Pancreas Biomedical Research Unit. PMID: 26071131; PMCID: PMC4920725.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    26. Impaired autophagy triggers chronic pancreatitis: lessons from pancreas-specific atg5 knockout mice. Gastroenterology. 2015 Mar; 148(3):501-5. Gukovsky I, Gukovskaya AS. PMID: 25613315; PMCID: PMC4443443.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    27. NADPH oxidase activation in pancreatic cancer cells is mediated through Akt-dependent up-regulation of p22phox. J Biol Chem. 2013 Dec 20; 288(51):36259. Edderkaoui M, Nitsche C, Zheng L, Pandol SJ, Gukovsky I, Gukovskaya AS. PMID: 24363267; PMCID: PMC3868740.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    28. High-fat, high-calorie diet promotes early pancreatic neoplasia in the conditional KrasG12D mouse model. Cancer Prev Res (Phila). 2013 Oct; 6(10):1064-73. Dawson DW, Hertzer K, Moro A, Donald G, Chang HH, Go VL, Pandol SJ, Lugea A, Gukovskaya AS, Li G, Hines OJ, Rozengurt E, Eibl G. PMID: 23943783; PMCID: PMC3835151.
      View in: PubMed   Mentions: 72     Fields:    Translation:Animals
    29. Inflammation, autophagy, and obesity: common features in the pathogenesis of pancreatitis and pancreatic cancer. Gastroenterology. 2013 Jun; 144(6):1199-209.e4. Gukovsky I, Li N, Todoric J, Gukovskaya A, Karin M. PMID: 23622129; PMCID: PMC3786712.
      View in: PubMed   Mentions: 163     Fields:    Translation:HumansAnimalsCells
    30. Akt kinase mediates the prosurvival effect of smoking compounds in pancreatic ductal cells. Pancreas. 2013 May; 42(4):655-62. Park CH, Lee IS, Grippo P, Pandol SJ, Gukovskaya AS, Edderkaoui M. PMID: 23271397; PMCID: PMC4085048.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    31. Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice. J Clin Invest. 2013 May; 123(5):2231-43. Li N, Wu X, Holzer RG, Lee JH, Todoric J, Park EJ, Ogata H, Gukovskaya AS, Gukovsky I, Pizzo DP, VandenBerg S, Tarin D, Atay C, Arkan MC, Deerinck TJ, Moscat J, Diaz-Meco M, Dawson D, Erkan M, Kleeff J, Karin M. PMID: 23563314; PMCID: PMC3635720.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    32. Nuclear factor-κB in pancreatitis: Jack-of-all-trades, but which one is more important? Gastroenterology. 2013 Jan; 144(1):26-9. Gukovsky I, Gukovskaya A. PMID: 23164573; PMCID: PMC6663071.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    33. Effects of oxidative alcohol metabolism on the mitochondrial permeability transition pore and necrosis in a mouse model of alcoholic pancreatitis. Gastroenterology. 2013 Feb; 144(2):437-446.e6. Shalbueva N, Mareninova OA, Gerloff A, Yuan J, Waldron RT, Pandol SJ, Gukovskaya AS. PMID: 23103769; PMCID: PMC3841074.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    34. Autophagy and pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2012 Nov 01; 303(9):G993-G1003. Gukovskaya AS, Gukovsky I. PMID: 22961802; PMCID: PMC3517664.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    35. The burning question: why is smoking a risk factor for pancreatic cancer? Pancreatology. 2012 Jul-Aug; 12(4):344-9. Pandol SJ, Apte MV, Wilson JS, Gukovskaya AS, Edderkaoui M. PMID: 22898636; PMCID: PMC3956306.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
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    42. The crucial role of early mitochondrial injury in L-lysine-induced acute pancreatitis. Antioxid Redox Signal. 2011 Nov 15; 15(10):2669-81. Biczó G, Hegyi P, Dósa S, Shalbuyeva N, Berczi S, Sinervirta R, Hracskó Z, Siska A, Kukor Z, Jármay K, Venglovecz V, Varga IS, Iványi B, Alhonen L, Wittmann T, Gukovskaya A, Takács T, Rakonczay Z. PMID: 21644850; PMCID: PMC4701124.
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    43. Baicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cells. Biochim Biophys Acta. 2011 Aug; 1813(8):1465-74. Takahashi H, Chen MC, Pham H, Angst E, King JC, Park J, Brovman EY, Ishiguro H, Harris DM, Reber HA, Hines OJ, Gukovskaya AS, Go VL, Eibl G. PMID: 21596068; PMCID: PMC3123440.
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    46. NADPH oxidase activation in pancreatic cancer cells is mediated through Akt-dependent up-regulation of p22phox. J Biol Chem. 2011 03 11; 286(10):7779-7787. Edderkaoui M, Nitsche C, Zheng L, Pandol SJ, Gukovsky I, Gukovskaya AS. PMID: 21118808; PMCID: PMC3048665.
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    47. Inhibitors of Bcl-2 protein family deplete ER Ca2+ stores in pancreatic acinar cells. Pflugers Arch. 2010 Oct; 460(5):891-900. Gerasimenko J, Ferdek P, Fischer L, Gukovskaya AS, Pandol SJ. PMID: 20617337; PMCID: PMC2937140.
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    48. Impaired autophagy underlies key pathological responses of acute pancreatitis. Autophagy. 2010 Apr; 6(3):428-9. Gukovsky I, Gukovskaya AS. PMID: 20215882; PMCID: PMC4580269.
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    49. Desmoplasia of pancreatic ductal adenocarcinoma. Clin Gastroenterol Hepatol. 2009 Nov; 7(11 Suppl):S44-7. Pandol S, Edderkaoui M, Gukovsky I, Lugea A, Gukovskaya A. PMID: 19896098; PMCID: PMC4573641.
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    50. Inflammatory cells regulate p53 and caspases in acute pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2010 Jan; 298(1):G92-100. Nakamura Y, Do JH, Yuan J, Odinokova IV, Mareninova O, Gukovskaya AS, Pandol SJ. PMID: 19850968; PMCID: PMC2806100.
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    51. Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis. J Clin Invest. 2009 Nov; 119(11):3340-55. Mareninova OA, Hermann K, French SW, O'Konski MS, Pandol SJ, Webster P, Erickson AH, Katunuma N, Gorelick FS, Gukovsky I, Gukovskaya AS. PMID: 19805911; PMCID: PMC2769194.
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    52. Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family. Am J Physiol Gastrointest Liver Physiol. 2010 Jan; 298(1):G63-73. Ohno I, Eibl G, Odinokova I, Edderkaoui M, Damoiseaux RD, Yazbec M, Abrol R, Goddard WA, Yokosuka O, Pandol SJ, Gukovskaya AS. PMID: 19762431; PMCID: PMC2806098.
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    53. Prosurvival Bcl-2 proteins stabilize pancreatic mitochondria and protect against necrosis in experimental pancreatitis. Exp Cell Res. 2009 Jul 01; 315(11):1975-89. Sung KF, Odinokova IV, Mareninova OA, Rakonczay Z, Hegyi P, Pandol SJ, Gukovsky I, Gukovskaya AS. PMID: 19331832; PMCID: PMC4545253.
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    54. Mechanisms regulating cytochrome c release in pancreatic mitochondria. Gut. 2009 Mar; 58(3):431-42. Odinokova IV, Sung KF, Mareninova OA, Hermann K, Evtodienko Y, Andreyev A, Gukovsky I, Gukovskaya AS. PMID: 18596195; PMCID: PMC4551464.
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    55. A new severe acute necrotizing pancreatitis model induced by L-ornithine in rats. Crit Care Med. 2008 Jul; 36(7):2117-27. Rakonczay Z, Hegyi P, Dósa S, Iványi B, Jármay K, Biczó G, Hracskó Z, Varga IS, Karg E, Kaszaki J, Varró A, Lonovics J, Boros I, Gukovsky I, Gukovskaya AS, Pandol SJ, Takács T. PMID: 18594222; PMCID: PMC6624069.
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    56. Ellagic acid induces apoptosis through inhibition of nuclear factor kappa B in pancreatic cancer cells. World J Gastroenterol. 2008 Jun 21; 14(23):3672-80. Edderkaoui M, Odinokova I, Ohno I, Gukovsky I, Go VL, Pandol SJ, Gukovskaya AS. PMID: 18595134; PMCID: PMC2719230.
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    57. Mitochondrial mechanisms of death responses in pancreatitis. J Gastroenterol Hepatol. 2008 Mar; 23 Suppl 1:S25-30. Odinokova IV, Sung KF, Mareninova OA, Hermann K, Gukovsky I, Gukovskaya AS. PMID: 18336659.
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    58. Mitochondrial injury in pancreatitis. Cell Calcium. 2008 Jul; 44(1):14-23. Mukherjee R, Criddle DN, Gukovskaya A, Gukvoskaya A, Pandol S, Petersen OH, Sutton R. PMID: 18207570; PMCID: PMC6663091.
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    59. NADPH oxidase promotes pancreatic cancer cell survival via inhibiting JAK2 dephosphorylation by tyrosine phosphatases. Gastroenterology. 2007 Nov; 133(5):1637-48. Lee JK, Edderkaoui M, Truong P, Ohno I, Jang KT, Berti A, Pandol SJ, Gukovskaya AS. PMID: 17983808.
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    60. Insulin-like growth factor-I receptor mediates the prosurvival effect of fibronectin. J Biol Chem. 2007 Sep 14; 282(37):26646-26655. Edderkaoui M, Hong P, Lee JK, Pandol SJ, Gukovskaya AS. PMID: 17627944.
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    61. Phosphatidylinositol 3-kinase facilitates bile acid-induced Ca(2+) responses in pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol. 2007 Mar; 292(3):G875-86. Fischer L, Gukovskaya AS, Penninger JM, Mareninova OA, Friess H, Gukovsky I, Pandol SJ. PMID: 17158252.
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    62. Cell death in pancreatitis: effects of alcohol. J Gastroenterol Hepatol. 2006 Oct; 21 Suppl 3:S10-3. Gukovskaya AS, Mareninova OA, Odinokova IV, Sung KF, Lugea A, Fischer L, Wang YL, Gukovsky I, Pandol SJ. PMID: 16958657.
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    63. Pancreas recovery following cerulein-induced pancreatitis is impaired in plasminogen-deficient mice. Gastroenterology. 2006 Sep; 131(3):885-99. Lugea A, Nan L, French SW, Bezerra JA, Gukovskaya AS, Pandol SJ. PMID: 16952557; PMCID: PMC1636452.
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    64. Ethanol feeding alters death signaling in the pancreas. Pancreas. 2006 May; 32(4):351-9. Wang YL, Hu R, Lugea A, Gukovsky I, Smoot D, Gukovskaya AS, Pandol SJ. PMID: 16670617.
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    65. Ethanol sensitizes NF-kappaB activation in pancreatic acinar cells through effects on protein kinase C-epsilon. Am J Physiol Gastrointest Liver Physiol. 2006 Sep; 291(3):G432-8. Satoh A, Gukovskaya AS, Reeve JR, Shimosegawa T, Pandol SJ. PMID: 16574982.
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    66. Cell death in pancreatitis: caspases protect from necrotizing pancreatitis. J Biol Chem. 2006 Feb 10; 281(6):3370-81. Mareninova OA, Sung KF, Hong P, Lugea A, Pandol SJ, Gukovsky I, Gukovskaya AS. PMID: 16339139.
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    67. Tumor necrosis factor-alpha mediates pancreatitis responses in acinar cells via protein kinase C and proline-rich tyrosine kinase 2. Gastroenterology. 2005 Aug; 129(2):639-51. Satoh A, Gukovskaya AS, Edderkaoui M, Daghighian MS, Reeve JR, Shimosegawa T, Pandol SJ. PMID: 16083718.
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    68. Extracellular matrix stimulates reactive oxygen species production and increases pancreatic cancer cell survival through 5-lipoxygenase and NADPH oxidase. Am J Physiol Gastrointest Liver Physiol. 2005 Dec; 289(6):G1137-47. Edderkaoui M, Hong P, Vaquero EC, Lee JK, Fischer L, Friess H, Buchler MW, Lerch MM, Pandol SJ, Gukovskaya AS. PMID: 16037546.
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    69. Alcohol and pancreatic cancer. Alcohol. 2005 Apr; 35(3):205-11. Go VL, Gukovskaya A, Pandol SJ. PMID: 16054982.
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    70. Cell death pathways in pancreatitis and pancreatic cancer. Pancreatology. 2004; 4(6):567-86. Gukovskaya AS, Pandol SJ. PMID: 15550766.
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    71. Phosphatidylinositol 3-kinase regulates Ca2+ signaling in pancreatic acinar cells through inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase. Am J Physiol Gastrointest Liver Physiol. 2004 Dec; 287(6):G1200-12. Fischer L, Gukovskaya AS, Young SH, Gukovsky I, Lugea A, Buechler P, Penninger JM, Friess H, Pandol SJ. PMID: 15271649.
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    72. Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells. J Biol Chem. 2004 Aug 13; 279(33):34643-54. Vaquero EC, Edderkaoui M, Pandol SJ, Gukovsky I, Gukovskaya AS. PMID: 15155719.
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    73. PKC-delta and -epsilon regulate NF-kappaB activation induced by cholecystokinin and TNF-alpha in pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol. 2004 Sep; 287(3):G582-91. Satoh A, Gukovskaya AS, Nieto JM, Cheng JH, Gukovsky I, Reeve JR, Shimosegawa T, Pandol SJ. PMID: 15117677.
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    74. Phosphatidylinositide 3-kinase gamma regulates key pathologic responses to cholecystokinin in pancreatic acinar cells. Gastroenterology. 2004 Feb; 126(2):554-66. Gukovsky I, Cheng JH, Nam KJ, Lee OT, Lugea A, Fischer L, Penninger JM, Pandol SJ, Gukovskaya AS. PMID: 14762792.
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    75. Nonoxidative ethanol metabolites alter extracellular matrix protein content in rat pancreas. Gastroenterology. 2003 Dec; 125(6):1845-59. Lugea A, Gukovsky I, Gukovskaya AS, Pandol SJ. PMID: 14724836.
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    76. Animal and in vitro models of alcoholic pancreatitis: role of cholecystokinin. Pancreas. 2003 Nov; 27(4):297-300. Pandol SJ, Gukovsky I, Satoh A, Lugea A, Gukovskaya AS. PMID: 14576490.
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    77. Extracellular matrix proteins protect pancreatic cancer cells from death via mitochondrial and nonmitochondrial pathways. Gastroenterology. 2003 Oct; 125(4):1188-202. Vaquero EC, Edderkaoui M, Nam KJ, Gukovsky I, Pandol SJ, Gukovskaya AS. PMID: 14517801.
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    78. Ethanol differentially regulates NF-kappaB activation in pancreatic acinar cells through calcium and protein kinase C pathways. Am J Physiol Gastrointest Liver Physiol. 2004 Feb; 286(2):G204-13. Gukovskaya AS, Hosseini S, Satoh A, Cheng JH, Nam KJ, Gukovsky I, Pandol SJ. PMID: 12958018.
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    79. Prevention of metastatic pancreatic cancer growth in vivo by induction of apoptosis with genistein, a naturally occurring isoflavonoid. Pancreas. 2003 Apr; 26(3):264-73. Büchler P, Gukovskaya AS, Mouria M, Büchler MC, Büchler MW, Friess H, Pandol SJ, Reber HA, Hines OJ. PMID: 12657953.
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    80. Curcumin ameliorates ethanol and nonethanol experimental pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2003 Jan; 284(1):G85-95. Gukovsky I, Reyes CN, Vaquero EC, Gukovskaya AS, Pandol SJ. PMID: 12488237.
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    81. Emerging concepts for the mechanism of alcoholic pancreatitis from experimental models. J Gastroenterol. 2003; 38(7):623-8. Pandol SJ, Gukovsky I, Satoh A, Lugea A, Gukovskaya AS. PMID: 12898353.
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    82. Cholecystokinin induces caspase activation and mitochondrial dysfunction in pancreatic acinar cells. Roles in cell injury processes of pancreatitis. J Biol Chem. 2002 Jun 21; 277(25):22595-604. Gukovskaya AS, Gukovsky I, Jung Y, Mouria M, Pandol SJ. PMID: 11964411.
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    83. Food-derived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C release and apoptosis. Int J Cancer. 2002 Apr 10; 98(5):761-9. Mouria M, Gukovskaya AS, Jung Y, Buechler P, Hines OJ, Reber HA, Pandol SJ. PMID: 11920648.
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    84. Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitis. Gastroenterology. 2002 Apr; 122(4):974-84. Gukovskaya AS, Vaquero E, Zaninovic V, Gorelick FS, Lusis AJ, Brennan ML, Holland S, Pandol SJ. PMID: 11910350.
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    85. Caspase 8-mediated cleavage of plectin precedes F-actin breakdown in acinar cells during pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2002 Mar; 282(3):G450-60. Beil M, Leser J, Lutz MP, Gukovskaya A, Seufferlein T, Lynch G, Pandol SJ, Adler G. PMID: 11841995.
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    86. Ethanol metabolism and transcription factor activation in pancreatic acinar cells in rats. Gastroenterology. 2002 Jan; 122(1):106-18. Gukovskaya AS, Mouria M, Gukovsky I, Reyes CN, Kasho VN, Faller LD, Pandol SJ. PMID: 11781286.
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    87. Localized pancreatic NF-kappaB activation and inflammatory response in taurocholate-induced pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2001 Jun; 280(6):G1197-208. Vaquero E, Gukovsky I, Zaninovic V, Gukovskaya AS, Pandol SJ. PMID: 11352813.
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    88. Activation of pancreatic acinar cells on isolation from tissue: cytokine upregulation via p38 MAP kinase. Am J Physiol Cell Physiol. 2000 Dec; 279(6):C1993-2003. Blinman TA, Gukovsky I, Mouria M, Zaninovic V, Livingston E, Pandol SJ, Gukovskaya AS. PMID: 11078716.
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    90. Endoplasmic reticulum Ca(2+)-ATPase inhibitors stimulate membrane guanylate cyclase in pancreatic acinar cells. Am J Physiol Cell Physiol. 2000 Feb; 278(2):C363-71. Gukovskaya AS, Gukovsky S, Pandol SJ. PMID: 10666032.
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    92. Amelioration of rat cerulein pancreatitis by guamerin-derived peptide, a novel elastase inhibitor. Pancreas. 1999 Apr; 18(3):231-9. Song M, Zaninovic V, Kim D, Gukovsky I, Gukovskaya A, Kang K, Pandol S. PMID: 10206480.
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    93. Early NF-kappaB activation is associated with hormone-induced pancreatitis. Am J Physiol. 1998 12; 275(6):G1402-14. Gukovsky I, Gukovskaya AS, Blinman TA, Zaninovic V, Pandol SJ. PMID: 9843778.
      View in: PubMed   Mentions: 144     Fields:    Translation:AnimalsCells
    94. Pancreatic acinar cells produce, release, and respond to tumor necrosis factor-alpha. Role in regulating cell death and pancreatitis. J Clin Invest. 1997 Oct 01; 100(7):1853-62. Gukovskaya AS, Gukovsky I, Zaninovic V, Song M, Sandoval D, Gukovsky S, Pandol SJ. PMID: 9312187; PMCID: PMC508372.
      View in: PubMed   Mentions: 121     Fields:    Translation:AnimalsCells
    95. The role of neutrophils and platelet-activating factor in mediating experimental pancreatitis. Gastroenterology. 1996 Oct; 111(4):1081-91. Sandoval D, Gukovskaya A, Reavey P, Gukovsky S, Sisk A, Braquet P, Pandol SJ, Poucell-Hatton S. PMID: 8831604.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    96. Mechanisms of cell death after pancreatic duct obstruction in the opossum and the rat. Gastroenterology. 1996 Mar; 110(3):875-84. Gukovskaya AS, Perkins P, Zaninovic V, Sandoval D, Rutherford R, Fitzsimmons T, Pandol SJ, Poucell-Hatton S. PMID: 8608898.
      View in: PubMed   Mentions: 43     Fields:    Translation:Animals
    97. Dual regulation of cGMP formation by calcium in pancreatic acinar cells. Am J Physiol. 1995 Jun; 268(6 Pt 1):G900-7. Gukovskaya AS, Pandol SJ. PMID: 7541946.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    98. Sphingosine regulates Ca(2+)-ATPase and reloading of intracellular Ca2+ stores in the pancreatic acinar cell. Biochim Biophys Acta. 1994 Oct 12; 1195(1):45-50. Pandol SJ, Schoeffield-Payne MS, Gukovskaya AS, Rutherford RE. PMID: 7918564.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    99. Cellular mechanisms mediating agonist-stimulated calcium influx in the pancreatic acinar cell. Ann N Y Acad Sci. 1994 Mar 23; 713:41-8. Pandol SJ, Gukovskaya A, Bahnson TD, Dionne VE. PMID: 8185204.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    100. Nitric oxide production regulates cGMP formation and calcium influx in pancreatic acinar cells. Am J Physiol. 1994 Mar; 266(3 Pt 1):G350-6. Gukovskaya A, Pandol S. PMID: 8166275.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    101. On the role of intracellular concentration of Ca2+ and H+ in thymocyte death after irradiation. FEBS Lett. 1993 Jun 21; 324(3):274-6. Shaposhnikova VV, Dobrovinskaya OR, Gukovskaya AS, Trepakova ES, Korystov YN. PMID: 8405365.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsPHPublic Health
    102. Activation of vacuolar-type proton pumps by protein kinase C. Role in neutrophil pH regulation. J Biol Chem. 1992 Nov 15; 267(32):22740-6. Nanda A, Gukovskaya A, Tseng J, Grinstein S. PMID: 1331065.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    103. Effect of the sulfhydryl reagent thimerosal on cytosolic free Ca2+ and membrane potential of thymocytes. Biochim Biophys Acta. 1992 Oct 19; 1111(1):65-74. Gukovskaya AS, Trepakova ES, Zinchenko VP, Korystov YN, Bezuglov VV. PMID: 1390866.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    104. Apoptosis of murine BW 5147 thymoma cells induced by cold shock. J Cell Physiol. 1992 Oct; 153(1):112-7. Kruman II, Gukovskaya AS, Petrunyaka VV, Beletsky IP, Trepakova ES. PMID: 1522125.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    105. G proteins in T cell signal transduction. Immunol Lett. 1992 Jan; 31(1):1-9. Gukovskaya AS. PMID: 1312509.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    106. Lipoxygenase inhibitors suppress intracellular calcium rise induced by ionomycin in rat thymocytes. Cell Calcium. 1990 Sep; 11(8):539-46. Gukovskaya AS, Arias Pulido H, Petrunyaka VV, Zinchenko VP, Bezuglov VV. PMID: 2124949.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    107. Cholera toxin and its B subunit do not change cytosolic free calcium concentration. Cell Calcium. 1990 Jun-Jul; 11(6):419-23. Astashkin EI, Surin AM, Mikhna MG, Nikolaeva IS, Lazarev AV, Gukovskaya AS. PMID: 2393900.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    108. The relationship between mitogen-induced changes in the cytoplasmic pH and free Ca2+ concentration in rat thymocytes. Biochim Biophys Acta. 1990 Mar 09; 1051(3):242-9. Gukovskaya AS, Zinchenko VP, Khodorov BI, Cragoe EJ. PMID: 2310775.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    109. Inhibitors of arachidonic acid metabolism eliminate the increase in cytosolic free calcium induced by the mitogen concanavalin A in rat thymocytes. FEBS Lett. 1989 Feb 27; 244(2):461-4. Gukovskaya AS, Pulido HA, Zinchenko VP. PMID: 2493398.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    110. Properties of different Ca2+ pools in permeabilized rat thymocytes. Eur J Biochem. 1986 Nov 17; 161(1):249-56. Gukovskaya AS, Zinchenko VP, Petrunyaka VV, Khodorov BI, Evtodienko YV. PMID: 3780738.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    111. The effects of ionophore A23187 and concanavalin A on the membrane potential of human peripheral blood lymphocytes and rat thymocytes. Biochim Biophys Acta. 1985 May 28; 815(3):433-40. Gukovskaya AS, Zinchenko VP. PMID: 3922416.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    112. Redistribution of intracellular Ca2+ in mitogen-stimulated human peripheral blood lymphocytes. Gen Physiol Biophys. 1983 Oct; 2(5):395-407. Gukovskaya AS, Zinchenko VP, Ryabichenko VV, Astashkin EI. PMID: 6432630.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    113. Calorimetric study of the complexes between polyuridylic acid and adenylic nucleotides. Nucleic Acids Res. 1981 Aug 25; 9(16):4061-79. Gukovskaya AS, Sukhomudrenko AG, Sukhorukov BI. PMID: 7301578; PMCID: PMC327414.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    114. Action of phalloidin on the mitotic cycle in Chinese hamster fibroblasts. Naturwissenschaften. 1980 Apr; 67(4):196-7. Gukovskaya AS, Gukovsky IY, Vexler AM, Popov VI, Budnitsky AA, Saxon ME. PMID: 7393336.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
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