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Miklos Sahin-Toth

Title(s)Professor-in-Residence, Surgery
SchoolMedicine
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    Collapse Overview 
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    Miklos Sahin-Toth, M.D., Ph.D., holds the Garry Shandling Chair in Pancreatic Diseases.

    Collapse Research 
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    Trypsin-dependent mechanisms in pancreatitis
    NIH R01DK117809Jul 1, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Digestive enzyme misfolding promotes alcoholic pancreatitis
    NIH R21AA026456Feb 15, 2018 - Jan 31, 2020
    Role: Principal Investigator
    Pancreatic elastases
    NIH R01DK095753Jan 1, 2013 - Dec 31, 2017
    Role: Principal Investigator
    Chymotrypsin C in pancreatitis
    NIH R01DK082412Dec 1, 2008 - Dec 31, 2024
    Role: Principal Investigator
    Role of trypsinogen sulfation in alcoholic pancreatitis
    NIH R21AA014544Sep 20, 2005 - Aug 31, 2008
    Role: Principal Investigator
    Molecular pathomechanism of hereditary pancreatitis
    NIH R01DK058088Jul 1, 2000 - Jun 30, 2021
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Minigenes enhance heterologous expression and prevent aberrant splicing of mouse Spink1. Sci Rep. 2025 Aug 02; 15(1):28222. Berke G, Sahin-Tóth M. PMID: 40753100; PMCID: PMC12318039.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Engineering mouse chymotrypsin B1 for improved trypsinogen degradation. Sci Rep. 2025 Mar 25; 15(1):10201. Morales Granda NC, Szabó A, Köller Z, Pál G, Sahin-Tóth M. PMID: 40133496; PMCID: PMC11937528.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. AlphaMissense versus laboratory-based pathogenicity prediction of 13 novel missense CPA1 variants from pancreatitis cases. Gut. 2025 Mar 06; 74(4):678-679. Sándor M, Scheers I, Masamune A, Witt H, LaRusch J, Chen JM, Németh BC, Geisz A, Uc A, Sahin-Tóth M. PMID: 39256032; PMCID: PMC11885027.
      View in: PubMed   Mentions: 3     Fields:    
    4. Misfolding PRSS1 variant p.Ala61Val in a case of suspected intrauterine pancreatitis. Pancreatology. 2025 Feb; 25(1):70-81. Sándor M, Vitale DS, Nagy ZA, Ibrahim SY, Abu-El-Haija M, Lazou M, Vajda S, Sahin-Tóth M. PMID: 39734120; PMCID: PMC12096409.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Intron-mediated enhancement of SPINK1 expression for pancreatitis therapy. Gut. 2024 Dec 10; 74(1):e9. Berke G, Sahin-Tóth M. PMID: 38754955; PMCID: PMC11631692.
      View in: PubMed   Mentions: 1     Fields:    
    6. Functional predictors of pathogenicity of missense CPA1 variants in chronic pancreatitis. Gut. 2024 Aug 08; 73(9):1589-1590. Sándor M, Sahin-Tóth M. PMID: 37857479; PMCID: PMC11031613.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    7. Secretagogue-induced pancreatitis in mice devoid of chymotrypsin. Am J Physiol Gastrointest Liver Physiol. 2024 Sep 01; 327(3):G333-G344. Demcsák A, Shariatzadeh S, Sahin-Tóth M. PMID: 38981616; PMCID: PMC11427105.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    8. Novel chymotrypsin C (CTRC) variants from real-world genetic testing of pediatric chronic pancreatitis cases. Pancreatology. 2024 Aug; 24(5):690-697. Stefanovics R, Sándor M, Demcsák A, Berke G, Németh BC, Zhang W, Abu-El-Haija M, Sahin-Tóth M. PMID: 38876922; PMCID: PMC11529566.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    9. Heterozygous Spink1 Deficiency Promotes Trypsin-dependent Chronic Pancreatitis in Mice. Cell Mol Gastroenterol Hepatol. 2024; 18(3):101361. Demcsák A, Sahin-Tóth M. PMID: 38768901; PMCID: PMC11292374.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    10. Mouse model of PRSS1 p.R122H-related hereditary pancreatitis highlights context-dependent effect of autolysis-site mutation. Pancreatology. 2023 Mar; 23(2):131-142. Jancsó Z, Morales Granda NC, Demcsák A, Sahin-Tóth M. PMID: 36797199; PMCID: PMC10492521.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    11. Rate of Autoactivation Determines Pancreatitis Phenotype in Trypsinogen Mutant Mice. Gastroenterology. 2022 09; 163(3):761-763. Demcsák A, Sahin-Tóth M. PMID: 35667407; PMCID: PMC9398983.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    12. Modelling chronic pancreatitis as a complex genetic disease in mice. Gut. 2023 02; 72(2):409-410. Jancsó Z, Demcsák A, Sahin-Tóth M. PMID: 35577534; PMCID: PMC9666703.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    13. Misfolding-induced chronic pancreatitis in CPA1 N256K mutant mice is unaffected by global deletion of Ddit3/Chop. Sci Rep. 2022 04 15; 12(1):6357. Németh BC, Demcsák A, Geisz A, Sahin-Tóth M. PMID: 35428786; PMCID: PMC9012826.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    14. Chronic progression of cerulein-induced acute pancreatitis in trypsinogen mutant mice. Pancreatology. 2022 Mar; 22(2):248-257. Jancsó Z, Sahin-Tóth M. PMID: 35063369; PMCID: PMC8941852.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    15. Evolutionary expansion of polyaspartate motif in the activation peptide of mouse cationic trypsinogen limits autoactivation and protects against pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2021 12 01; 321(6):G719-G734. Orekhova A, Németh BC, Jancsó Z, Geisz A, Mosztbacher D, Demcsák A, Sahin-Tóth M. PMID: 34643096; PMCID: PMC8668397.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    16. Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis. J Biol Chem. 2021 Jan-Jun; 296:100343. Szabó A, Toldi V, Gazda LD, Demcsák A, Tozsér J, Sahin-Tóth M. PMID: 33515547; PMCID: PMC7949130.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    17. Mouse model suggests limited role for human mesotrypsin in pancreatitis. Pancreatology. 2021 Mar; 21(2):342-352. Mosztbacher D, Sahin-Tóth M. PMID: 33526384; PMCID: PMC7969449.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    18. Lipotoxicity and Cytokine Storm in Severe Acute Pancreatitis and COVID-19. Gastroenterology. 2020 09; 159(3):824-827. Hegyi P, Szakács Z, Sahin-Tóth M. PMID: 32682765; PMCID: PMC7366088.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCellsPHPublic Health
    19. Loss of chymotrypsin-like protease (CTRL) alters intrapancreatic protease activation but not pancreatitis severity in mice. Sci Rep. 2020 07 16; 10(1):11731. Mosztbacher D, Jancsó Z, Sahin-Tóth M. PMID: 32678161; PMCID: PMC7366634.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    20. Channelopathy of the Pancreas Causes Chronic Pancreatitis. Gastroenterology. 2020 05; 158(6):1538-1540. Sahin-Tóth M. PMID: 32205170; PMCID: PMC7751598.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    21. Inactivation of mesotrypsin by chymotrypsin C prevents trypsin inhibitor degradation. J Biol Chem. 2020 03 13; 295(11):3447-3455. Toldi V, Szabó A, Sahin-Tóth M. PMID: 32014997; PMCID: PMC7076226.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    22. Measuring digestive protease activation in the mouse pancreas. Pancreatology. 2020 Mar; 20(2):288-292. Mosztbacher D, Demcsák A, Sahin-Tóth M. PMID: 31899136; PMCID: PMC7103542.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    23. Mutation That Promotes Activation of Trypsinogen Increases Severity of Secretagogue-Induced Pancreatitis in Mice. Gastroenterology. 2020 03; 158(4):1083-1094. Jancsó Z, Sahin-Tóth M. PMID: 31751559; PMCID: PMC7062587.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    24. Alcohol-dependent effect of PRSS1-PRSS2 haplotype in chronic pancreatitis. Gut. 2020 09; 69(9):1713-1715. Hegyi E, Tóth AZ, Vincze Á, Szentesi A, Hegyi P, Sahin-Tóth M. PMID: 31506327; PMCID: PMC7062586.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    25. Engineering mouse cationic trypsinogen for rapid and selective activation by cathepsin B. Sci Rep. 2019 06 24; 9(1):9188. Demcsák A, Geisz A, Sahin-Tóth M. PMID: 31235832; PMCID: PMC6591424.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    26. Changing the lactose permease of Escherichia coli into a galactose-specific symporter. Proc Natl Acad Sci U S A. 2002 May 14; 99(10):6613-8. Guan L, Sahin-Toth M, Kaback HR. PMID: 12011425; PMCID: PMC124451.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    27. Hereditary pancreatitis caused by a novel PRSS1 mutation (Arg-122 --> Cys) that alters autoactivation and autodegradation of cationic trypsinogen. J Biol Chem. 2002 Feb 15; 277(7):5404-10. Simon P, Weiss FU, Sahin-Toth M, Parry M, Nayler O, Lenfers B, Schnekenburger J, Mayerle J, Domschke W, Lerch MM. PMID: 11719509.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    28. Arg-302 facilitates deprotonation of Glu-325 in the transport mechanism of the lactose permease from Escherichiacoli. Proc Natl Acad Sci U S A. 2001 May 22; 98(11):6068-73. Sahin-Toth M, Kaback HR. PMID: 11353849; PMCID: PMC33423.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
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