Miklos Sahin-Toth

Title(s)Professor-in-Residence, Surgery
SchoolMedicine
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    Miklos Sahin-Toth, M.D., Ph.D., holds the Garry Shandling Chair in Pancreatic Diseases.

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    Trypsin-dependent mechanisms in pancreatitis
    NIH R01DK117809Jul 1, 2018 - Mar 31, 2024
    Role: Principal Investigator
    Digestive enzyme misfolding promotes alcoholic pancreatitis
    NIH R21AA026456Feb 15, 2018 - Jan 31, 2020
    Role: Principal Investigator
    Pancreatic elastases
    NIH R01DK095753Jan 1, 2013 - Dec 31, 2017
    Role: Principal Investigator
    Chymotrypsin in pancreatitis
    NIH R01DK082412Dec 1, 2008 - Dec 31, 2024
    Role: Principal Investigator
    Role of trypsinogen sulfation in alcoholic pancreatitis
    NIH R21AA014544Sep 20, 2005 - Aug 31, 2008
    Role: Principal Investigator
    Molecular pathomechanism of hereditary pancreatitis
    NIH R01DK058088Jul 1, 2000 - Jun 30, 2021
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pancreatitis-associated SPINK1 Variant c.-53C>T Reduces Trypsin Inhibitor Translation. Pancreas. 2026 Sep 18. Attila Nagy Z, Sahin-Tóth M. PMID: 42757647.
      View in: PubMed   Mentions:
    2. SPINK1 p.Asn34Ser Haplotype Reduces Pancreatic Trypsin Inhibitor Messenger RNA in Chronic Pancreatitis Patients Undergoing Total Pancreatectomy With Islet Autotransplantation. Gastroenterology. 2026 Aug; 171(2):370-372. Berke G, Abu-El-Haija M, Morgan K, Singh VK, Bellin MD, Sahin-Tóth M. PMID: 41932452.
      View in: PubMed   Mentions:    Fields:    
    3. Pancreatitis-associated chymotrypsin C (CTRC) variant p.R240Q selectively impairs trypsinogen degradation through disruption of long-range electrostatic interactions. Sci Rep. 2026 Feb 24; 16(1). Nagy ZA, Sándor M, Hegyi E, Jurícek R, Hrcková G, Sahin-Tóth M. PMID: 41735424; PMCID: PMC12987931.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Mutations of Gly277 in CPA1-related chronic pancreatitis: clinical clues for misfolding aetiology. Gut. 2026 Jan 06. Zheng Y, Scheers I, Sándor M, Yi G, Sahin-Tóth M. PMID: 41494808; PMCID: PMC12970559.
      View in: PubMed   Mentions:    Fields:    
    5. Chymotrypsin Deficiency Accelerates Precancerous Remodeling of the Pancreas in KC Mice. Pancreas. 2026 Jan 01; 55(1):e30-e32. Demcsák A, Sándor M, Sahin-Tóth M. PMID: 41182168; PMCID: PMC12823121.
      View in: PubMed   Mentions:    Fields:    
    6. Misfolding CPA1 mutation accelerates precancerous pancreas lesions in KC mice. Am J Physiol Gastrointest Liver Physiol. 2025 10 01; 329(4):G546-G556. Demcsák A, Sahin-Tóth M. PMID: 40982355; PMCID: PMC12829554.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    7. Diverse Misfolding Mutant Digestive Enzymes Cause Chronic Pancreatitis Through Common Pathways. Cell Mol Gastroenterol Hepatol. 2026; 20(2):101638. Wilhelm SJ, Curry GE, Matiwala N, Lin J, Quach T, Lowe ME, Sahin-Tóth M, Xiao XK. PMID: 40992738; PMCID: PMC12681743.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    8. Chymotrypsin B2 (CTRB2) Deletion Variant Induces Endoplasmic Reticulum Stress but does not Increase Risk for Chronic Pancreatitis. Pancreas. 2025 Aug 04. Demcsák A, Hegyi E, Hegyi P, Rosendahl J, Sahin-Tóth M. PMID: 40748831; PMCID: PMC12823123.
      View in: PubMed   Mentions:    Fields:    
    9. Minigenes enhance heterologous expression and prevent aberrant splicing of mouse Spink1. Sci Rep. 2025 Aug 02; 15(1):28222. Berke G, Sahin-Tóth M. PMID: 40753100; PMCID: PMC12318039.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    10. Strain-specific differences in cerulein-induced acute and recurrent acute murine pancreatitis. Sci Rep. 2025 May 08; 15(1):16030. Demcsák A, Tran T, Sahin-Tóth M, Geisz-Fremy A. PMID: 40341748; PMCID: PMC12062244.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    11. To be, or not to be cleaved: Directed evolution of a canonical serine protease inhibitor against active and inactive protease pair identifies binding loop residue critical for prevention of proteolytic cleavage. Protein Sci. 2025 05; 34(5):e70146. Köller Z, Németh BZ, Kiss B, Nagy ZA, Schlosser G, Magyar C, Demcsák A, Sahin-Tóth M, Pál G. PMID: 40298105; PMCID: PMC12038735.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    12. Engineering mouse chymotrypsin B1 for improved trypsinogen degradation. Sci Rep. 2025 Mar 25; 15(1):10201. Morales Granda NC, Szabó A, Köller Z, Pál G, Sahin-Tóth M. PMID: 40133496; PMCID: PMC11937528.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    13. Chronic pancreatitis in T7C140S mice with misfolding cationic trypsinogen mutant. JCI Insight. 2025 Apr 22; 10(8). Sándor M, Németh BC, Demcsák A, Sahin-Tóth M. PMID: 40067384; PMCID: PMC12016918.
      View in: PubMed   Mentions: 1     Fields:    
    14. AlphaMissense versus laboratory-based pathogenicity prediction of 13 novel missense CPA1 variants from pancreatitis cases. Gut. 2025 Mar 06; 74(4):678-679. Sándor M, Scheers I, Masamune A, Witt H, LaRusch J, Chen JM, Németh BC, Geisz A, Uc A, Sahin-Tóth M. PMID: 39256032; PMCID: PMC11885027.
      View in: PubMed   Mentions: 5     Fields:    
    15. Carboxyl ester lipase hybrid 1 (CEL-HYB1) haplotypes confer varying risk for chronic pancreatitis. Sci Rep. 2024 12 28; 14(1):30965. Berke G, Sándor M, Xiao XK, Lowe ME, Ewers M, Eross B, Masson E, Németh BC, Vincze Á, Czakó L, Rygiel AM, Rosendahl J, Chen JM, Witt H, Hegyi P, Sahin-Tóth M, Hegyi E. PMID: 39730750; PMCID: PMC11680782.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Misfolding PRSS1 variant p.Ala61Val in a case of suspected intrauterine pancreatitis. Pancreatology. 2025 Feb; 25(1):70-81. Sándor M, Vitale DS, Nagy ZA, Ibrahim SY, Abu-El-Haija M, Lazou M, Vajda S, Sahin-Tóth M. PMID: 39734120; PMCID: PMC12096409.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    17. Intron-mediated enhancement of SPINK1 expression for pancreatitis therapy. Gut. 2024 Dec 10; 74(1):e9. Berke G, Sahin-Tóth M. PMID: 38754955; PMCID: PMC11631692.
      View in: PubMed   Mentions: 2     Fields:    
    18. The High-Affinity Chymotrypsin Inhibitor Eglin C Poorly Inhibits Human Chymotrypsin-Like Protease: Gln192 and Lys218 Are Key Determinants. Proteins. 2025 02; 93(2):543-554. Németh BZ, Kiss B, Sahin-Tóth M, Magyar C, Pál G. PMID: 39301701; PMCID: PMC11694548.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    19. Functional predictors of pathogenicity of missense CPA1 variants in chronic pancreatitis. Gut. 2024 08 08; 73(9):1589-1590. Sándor M, Sahin-Tóth M. PMID: 37857479; PMCID: PMC11031613.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    20. Secretagogue-induced pancreatitis in mice devoid of chymotrypsin. Am J Physiol Gastrointest Liver Physiol. 2024 09 01; 327(3):G333-G344. Demcsák A, Shariatzadeh S, Sahin-Tóth M. PMID: 38981616; PMCID: PMC11427105.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    21. Novel chymotrypsin C (CTRC) variants from real-world genetic testing of pediatric chronic pancreatitis cases. Pancreatology. 2024 Aug; 24(5):690-697. Stefanovics R, Sándor M, Demcsák A, Berke G, Németh BC, Zhang W, Abu-El-Haija M, Sahin-Tóth M. PMID: 38876922; PMCID: PMC11529566.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    22. Heterozygous Spink1 Deficiency Promotes Trypsin-dependent Chronic Pancreatitis in Mice. Cell Mol Gastroenterol Hepatol. 2024; 18(3):101361. Demcsák A, Sahin-Tóth M. PMID: 38768901; PMCID: PMC11292374.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    23. Mouse model of PRSS1 p.R122H-related hereditary pancreatitis highlights context-dependent effect of autolysis-site mutation. Pancreatology. 2023 Mar; 23(2):131-142. Jancsó Z, Morales Granda NC, Demcsák A, Sahin-Tóth M. PMID: 36797199; PMCID: PMC10492521.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    24. Rate of Autoactivation Determines Pancreatitis Phenotype in Trypsinogen Mutant Mice. Gastroenterology. 2022 09; 163(3):761-763. Demcsák A, Sahin-Tóth M. PMID: 35667407; PMCID: PMC9398983.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    25. Modelling chronic pancreatitis as a complex genetic disease in mice. Gut. 2023 02; 72(2):409-410. Jancsó Z, Demcsák A, Sahin-Tóth M. PMID: 35577534; PMCID: PMC9666703.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    26. Misfolding-induced chronic pancreatitis in CPA1 N256K mutant mice is unaffected by global deletion of Ddit3/Chop. Sci Rep. 2022 04 15; 12(1):6357. Németh BC, Demcsák A, Geisz A, Sahin-Tóth M. PMID: 35428786; PMCID: PMC9012826.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    27. Chronic progression of cerulein-induced acute pancreatitis in trypsinogen mutant mice. Pancreatology. 2022 Mar; 22(2):248-257. Jancsó Z, Sahin-Tóth M. PMID: 35063369; PMCID: PMC8941852.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    28. Evolutionary expansion of polyaspartate motif in the activation peptide of mouse cationic trypsinogen limits autoactivation and protects against pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2021 12 01; 321(6):G719-G734. Orekhova A, Németh BC, Jancsó Z, Geisz A, Mosztbacher D, Demcsák A, Sahin-Tóth M. PMID: 34643096; PMCID: PMC8668397.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    29. Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis. J Biol Chem. 2021 Jan-Jun; 296:100343. Szabó A, Toldi V, Gazda LD, Demcsák A, Tozsér J, Sahin-Tóth M. PMID: 33515547; PMCID: PMC7949130.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    30. Mouse model suggests limited role for human mesotrypsin in pancreatitis. Pancreatology. 2021 Mar; 21(2):342-352. Mosztbacher D, Sahin-Tóth M. PMID: 33526384; PMCID: PMC7969449.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    31. Lipotoxicity and Cytokine Storm in Severe Acute Pancreatitis and COVID-19. Gastroenterology. 2020 09; 159(3):824-827. Hegyi P, Szakács Z, Sahin-Tóth M. PMID: 32682765; PMCID: PMC7366088.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCellsPHPublic Health
    32. Loss of chymotrypsin-like protease (CTRL) alters intrapancreatic protease activation but not pancreatitis severity in mice. Sci Rep. 2020 07 16; 10(1):11731. Mosztbacher D, Jancsó Z, Sahin-Tóth M. PMID: 32678161; PMCID: PMC7366634.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    33. Channelopathy of the Pancreas Causes Chronic Pancreatitis. Gastroenterology. 2020 05; 158(6):1538-1540. Sahin-Tóth M. PMID: 32205170; PMCID: PMC7751598.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    34. Inactivation of mesotrypsin by chymotrypsin C prevents trypsin inhibitor degradation. J Biol Chem. 2020 03 13; 295(11):3447-3455. Toldi V, Szabó A, Sahin-Tóth M. PMID: 32014997; PMCID: PMC7076226.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    35. Measuring digestive protease activation in the mouse pancreas. Pancreatology. 2020 Mar; 20(2):288-292. Mosztbacher D, Demcsák A, Sahin-Tóth M. PMID: 31899136; PMCID: PMC7103542.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    36. Mutation That Promotes Activation of Trypsinogen Increases Severity of Secretagogue-Induced Pancreatitis in Mice. Gastroenterology. 2020 03; 158(4):1083-1094. Jancsó Z, Sahin-Tóth M. PMID: 31751559; PMCID: PMC7062587.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    37. Alcohol-dependent effect of PRSS1-PRSS2 haplotype in chronic pancreatitis. Gut. 2020 09; 69(9):1713-1715. Hegyi E, Tóth AZ, Vincze Á, Szentesi A, Hegyi P, Sahin-Tóth M. PMID: 31506327; PMCID: PMC7062586.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    38. Engineering mouse cationic trypsinogen for rapid and selective activation by cathepsin B. Sci Rep. 2019 06 24; 9(1):9188. Demcsák A, Geisz A, Sahin-Tóth M. PMID: 31235832; PMCID: PMC6591424.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    39. Changing the lactose permease of Escherichia coli into a galactose-specific symporter. Proc Natl Acad Sci U S A. 2002 May 14; 99(10):6613-8. Guan L, Sahin-Toth M, Kaback HR. PMID: 12011425; PMCID: PMC124451.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    40. Hereditary pancreatitis caused by a novel PRSS1 mutation (Arg-122 --> Cys) that alters autoactivation and autodegradation of cationic trypsinogen. J Biol Chem. 2002 Feb 15; 277(7):5404-10. Simon P, Weiss FU, Sahin-Toth M, Parry M, Nayler O, Lenfers B, Schnekenburger J, Mayerle J, Domschke W, Lerch MM. PMID: 11719509.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    41. Arg-302 facilitates deprotonation of Glu-325 in the transport mechanism of the lactose permease from Escherichiacoli. Proc Natl Acad Sci U S A. 2001 May 22; 98(11):6068-73. Sahin-Toth M, Kaback HR. PMID: 11353849; PMCID: PMC33423.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
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