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Chesnokova, Vera M

Title(s)Adjunct Professor, Medicine
SchoolEndocrinology
Phone(310) 423-7659
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    Collapse Research 
    Collapse Research Activities and Funding
    Role of p21 in antidepressant-induced neurogenesis
    NIH/NIMH R21MH079988Dec 10, 2007 - Nov 30, 2010
    Role: Principal Investigator
    LIF MEDIATES ACTH AXIS RESPONSE TO INFLAMMATION
    NIH/NIDDK R29DK054862Feb 10, 1999 - Jan 31, 2004
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Chesnokova V, Melmed S. Growth hormone in the tumor microenvironment. Arch Endocrinol Metab. 2019 Nov-Dec; 63(6):568-575. PMID: 31939481.
      View in: PubMed
    2. Chesnokova V, Zonis S, Barrett RJ, Gleeson JP, Melmed S. Growth Hormone Induces Colon DNA Damage Independent of IGF-1. Endocrinology. 2019 06 01; 160(6):1439-1447. PMID: 31002310.
      View in: PubMed
    3. Chesnokova V, Zonis S, Barrett R, Kameda H, Wawrowsky K, Ben-Shlomo A, Yamamoto M, Gleeson J, Bresee C, Gorbunova V, Melmed S. Excess growth hormone suppresses DNA damage repair in epithelial cells. JCI Insight. 2019 Feb 07; 4(3). PMID: 30728323.
      View in: PubMed
    4. Zonis S, Breunig JJ, Mamelak A, Wawrowsky K, Bresee C, Ginzburg N, Chesnokova V. Inflammation-induced Gro1 triggers senescence in neuronal progenitors: effects of estradiol. J Neuroinflammation. 2018 Sep 11; 15(1):260. PMID: 30201019.
      View in: PubMed
    5. Recouvreux MV, Wu JB, Gao AC, Zonis S, Chesnokova V, Bhowmick N, Chung LW, Melmed S. Androgen Receptor Regulation of Local Growth Hormone in Prostate Cancer Cells. Endocrinology. 2017 07 01; 158(7):2255-2268. PMID: 28444169.
      View in: PubMed
    6. Chesnokova V, Zonis S, Zhou C, Recouvreux MV, Ben-Shlomo A, Araki T, Barrett R, Workman M, Wawrowsky K, Ljubimov VA, Uhart M, Melmed S. Growth hormone is permissive for neoplastic colon growth. Proc Natl Acad Sci U S A. 2016 Jun 07; 113(23):E3250-9. PMID: 27226307.
      View in: PubMed
    7. Chesnokova V, Pechnick RN, Wawrowsky K. Chronic peripheral inflammation, hippocampal neurogenesis, and behavior. Brain Behav Immun. 2016 Nov; 58:1-8. PMID: 26802985.
      View in: PubMed
    8. Chesnokova V, Pechnick RN. New Signaling Pathway for Gut-Brain Interactions. Neuropsychopharmacology. 2016 Jan; 41(1):372-3. PMID: 26657951.
      View in: PubMed
    9. Zonis S, Pechnick RN, Ljubimov VA, Mahgerefteh M, Wawrowsky K, Michelsen KS, Chesnokova V. Chronic intestinal inflammation alters hippocampal neurogenesis. J Neuroinflammation. 2015 Apr 03; 12:65. PMID: 25889852.
      View in: PubMed
    10. Zonis S, Ljubimov VA, Mahgerefteh M, Pechnick RN, Wawrowsky K, Chesnokova V. p21Cip restrains hippocampal neurogenesis and protects neuronal progenitors from apoptosis during acute systemic inflammation. Hippocampus. 2013 Dec; 23(12):1383-94. PMID: 23966332.
      View in: PubMed
    11. Chesnokova V, Zhou C, Ben-Shlomo A, Zonis S, Tani Y, Ren SG, Melmed S. Growth hormone is a cellular senescence target in pituitary and nonpituitary cells. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):E3331-9. PMID: 23940366.
      View in: PubMed
    12. Ben-Shlomo A, Pichurin O, Khalafi R, Zhou C, Chesnokova V, Ren SG, Liu NA, Melmed S. Constitutive somatostatin receptor subtype 2 activity attenuates GH synthesis. Endocrinology. 2013 Jul; 154(7):2399-409. PMID: 23696564.
      View in: PubMed
    13. Chesnokova V, Zonis S, Wawrowsky K, Tani Y, Ben-Shlomo A, Ljubimov V, Mamelak A, Bannykh S, Melmed S. Clusterin and FOXL2 act concordantly to regulate pituitary gonadotroph adenoma growth. Mol Endocrinol. 2012 Dec; 26(12):2092-103. PMID: 23051594.
      View in: PubMed
    14. Toledano Y, Zonis S, Ren SG, Wawrowsky K, Chesnokova V, Melmed S. Estradiol partially recapitulates murine pituitary cell cycle response to pregnancy. Endocrinology. 2012 Oct; 153(10):5011-22. PMID: 22851678.
      View in: PubMed
    15. Pechnick RN, Zonis S, Wawrowsky K, Cosgayon R, Farrokhi C, Lacayo L, Chesnokova V. Antidepressants stimulate hippocampal neurogenesis by inhibiting p21 expression in the subgranular zone of the hipppocampus. PLoS One. 2011; 6(11):e27290. PMID: 22076148.
      View in: PubMed
    16. Chesnokova V, Zonis S, Zhou C, Ben-Shlomo A, Wawrowsky K, Toledano Y, Tong Y, Kovacs K, Scheithauer B, Melmed S. Lineage-specific restraint of pituitary gonadotroph cell adenoma growth. PLoS One. 2011 Mar 25; 6(3):e17924. PMID: 21464964.
      View in: PubMed
    17. Chesnokova V, Zonis S, Ben-Shlomo A, Wawrowsky K, Melmed S. Molecular mechanisms of pituitary adenoma senescence. Front Horm Res. 2010; 38:7-14. PMID: 20616490.
      View in: PubMed
    18. Chesnokova V, Melmed S. Pituitary senescence: the evolving role of Pttg. Mol Cell Endocrinol. 2010 Sep 15; 326(1-2):55-9. PMID: 20153804.
      View in: PubMed
    19. Ben-Shlomo A, Schmid H, Wawrowsky K, Pichurin O, Hubina E, Chesnokova V, Liu NA, Culler M, Melmed S. Differential Ligand-Mediated Pituitary Somatostatin Receptor Subtype Signaling: Implications for Corticotroph Tumor Therapy. Endocr Rev. 2009 Dec 01; 30(7):933. PMID: 28199544.
      View in: PubMed
    20. Ben-Shlomo A, Schmid H, Wawrowsky K, Pichurin O, Hubina E, Chesnokova V, Liu NA, Culler M, Melmed S. Differential ligand-mediated pituitary somatostatin receptor subtype signaling: implications for corticotroph tumor therapy. J Clin Endocrinol Metab. 2009 Nov; 94(11):4342-50. PMID: 19820006.
      View in: PubMed
    21. Chesnokova V, Melmed S. Pituitary tumour-transforming gene (PTTG) and pituitary senescence. Horm Res. 2009 Apr; 71 Suppl 2:82-7. PMID: 19407503.
      View in: PubMed
    22. Arzt E, Chesnokova V, Stalla GK, Melmed S. Pituitary adenoma growth: a model for cellular senescence and cytokine action. Cell Cycle. 2009 Mar 01; 8(5):677-8. PMID: 19223763.
      View in: PubMed
    23. Chesnokova V, Wong C, Zonis S, Gruszka A, Wawrowsky K, Ren SG, Benshlomo A, Yu R. Diminished pancreatic beta-cell mass in securin-null mice is caused by beta-cell apoptosis and senescence. Endocrinology. 2009 Jun; 150(6):2603-10. PMID: 19213844.
      View in: PubMed
    24. Ben-Shlomo A, Zhou C, Pichurin O, Chesnokova V, Liu NA, Culler MD, Melmed S. Constitutive somatostatin receptor activity determines tonic pituitary cell response. Mol Endocrinol. 2009 Mar; 23(3):337-48. PMID: 19131507.
      View in: PubMed
    25. Pechnick RN, Chesnokova V. Adult neurogenesis, cell cycle and drug discovery in psychiatry. Neuropsychopharmacology. 2009 Jan; 34(1):244. PMID: 19079068.
      View in: PubMed
    26. Chesnokova V, Zonis S, Kovacs K, Ben-Shlomo A, Wawrowsky K, Bannykh S, Melmed S. p21(Cip1) restrains pituitary tumor growth. Proc Natl Acad Sci U S A. 2008 Nov 11; 105(45):17498-503. PMID: 18981426.
      View in: PubMed
    27. Chesnokova V, Pechnick RN. Antidepressants and Cdk inhibitors: releasing the brake on neurogenesis? Cell Cycle. 2008 Aug; 7(15):2321-6. PMID: 18682686.
      View in: PubMed
    28. Pechnick RN, Zonis S, Wawrowsky K, Pourmorady J, Chesnokova V. p21Cip1 restricts neuronal proliferation in the subgranular zone of the dentate gyrus of the hippocampus. Proc Natl Acad Sci U S A. 2008 Jan 29; 105(4):1358-63. PMID: 18172194.
      View in: PubMed
    29. Chesnokova V, Zonis S, Rubinek T, Yu R, Ben-Shlomo A, Kovacs K, Wawrowsky K, Melmed S. Senescence mediates pituitary hypoplasia and restrains pituitary tumor growth. Cancer Res. 2007 Nov 01; 67(21):10564-72. PMID: 17975001.
      View in: PubMed
    30. Rubinek T, Chesnokova V, Wolf I, Wawrowsky K, Vlotides G, Melmed S. Discordant proliferation and differentiation in pituitary tumor-transforming gene-null bone marrow stem cells. Am J Physiol Cell Physiol. 2007 Sep; 293(3):C1082-92. PMID: 17626243.
      View in: PubMed
    31. Ben-Shlomo A, Pichurin O, Barshop NJ, Wawrowsky KA, Taylor J, Culler MD, Chesnokova V, Liu NA, Melmed S. Selective regulation of somatostatin receptor subtype signaling: evidence for constitutive receptor activation. Mol Endocrinol. 2007 Oct; 21(10):2565-78. PMID: 17609435.
      View in: PubMed
    32. Pechnick RN, Kariagina A, Hartvig E, Bresee CJ, Poland RE, Chesnokova VM. Developmental exposure to corticosterone: behavioral changes and differential effects on leukemia inhibitory factor (LIF) and corticotropin-releasing hormone (CRH) gene expression in the mouse. Psychopharmacology (Berl). 2006 Mar; 185(1):76-83. PMID: 16416158.
      View in: PubMed
    33. Kariagina A, Zonis S, Afkhami M, Romanenko D, Chesnokova V. Leukemia inhibitory factor regulates glucocorticoid receptor expression in the hypothalamic-pituitary-adrenal axis. Am J Physiol Endocrinol Metab. 2005 Nov; 289(5):E857-63. PMID: 15985451.
      View in: PubMed
    34. Chesnokova V, Kovacs K, Castro AV, Zonis S, Melmed S. Pituitary hypoplasia in Pttg-/- mice is protective for Rb+/- pituitary tumorigenesis. Mol Endocrinol. 2005 Sep; 19(9):2371-9. PMID: 15919720.
      View in: PubMed
    35. Pechnick RN, Chesnokova VM, Kariagina A, Price S, Bresee CJ, Poland RE. Reduced immobility in the forced swim test in mice with a targeted deletion of the leukemia inhibitory factor (LIF) gene. Neuropsychopharmacology. 2004 Apr; 29(4):770-6. PMID: 14970834.
      View in: PubMed
    36. Kariagina A, Romanenko D, Ren SG, Chesnokova V. Hypothalamic-pituitary cytokine network. Endocrinology. 2004 Jan; 145(1):104-12. PMID: 14512435.
      View in: PubMed
    37. Chesnokova V, Kariagina A, Melmed S. Opposing effects of pituitary leukemia inhibitory factor and SOCS-3 on the ACTH axis response to inflammation. Am J Physiol Endocrinol Metab. 2002 May; 282(5):E1110-8. PMID: 11934677.
      View in: PubMed
    38. Chesnokova V, Melmed S. Minireview: Neuro-immuno-endocrine modulation of the hypothalamic-pituitary-adrenal (HPA) axis by gp130 signaling molecules. Endocrinology. 2002 May; 143(5):1571-4. PMID: 11956136.
      View in: PubMed