Shlomo K Melmed

Title(s)Professor-in-Residence, Medicine
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    1. DNA damage and growth hormone hypersecretion in pituitary somatotroph adenomas. J Clin Invest. 2020 11 02; 130(11):5738-5755. Ben-Shlomo A, Deng N, Ding E, Yamamoto M, Mamelak A, Chesnokova V, Labadzhyan A, Melmed S. PMID: 32673291; PMCID: PMC7598090.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    2. Peptide Hormone Regulation of DNA Damage Responses. Endocr Rev. 2020 07 01; 41(4). Chesnokova V, Melmed S. PMID: 32270196; PMCID: PMC7279704.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    3. Pituitary-Tumor Endocrinopathies. N Engl J Med. 2020 03 05; 382(10):937-950. Melmed S. PMID: 32130815.
      View in: PubMed   Mentions: 113     Fields:    Translation:Humans
    4. Growth hormone in the tumor microenvironment. Arch Endocrinol Metab. 2019 Nov-Dec; 63(6):568-575. Chesnokova V, Melmed S. PMID: 31939481; PMCID: PMC7025769.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    5. Pathogenesis and Diagnosis of Growth Hormone Deficiency in Adults. N Engl J Med. 2019 06 27; 380(26):2551-2562. Melmed S. PMID: 31242363.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    6. Growth Hormone Induces Colon DNA Damage Independent of IGF-1. Endocrinology. 2019 06 01; 160(6):1439-1447. Chesnokova V, Zonis S, Barrett RJ, Gleeson JP, Melmed S. PMID: 31002310; PMCID: PMC6530523.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    7. Proton Sensitivity of Corticotropin-Releasing Hormone Receptor 1 Signaling to Proopiomelanocortin in Male Mice. Endocrinology. 2019 02 01; 160(2):276-291. Kameda H, Yamamoto M, Tone Y, Tone M, Melmed S. PMID: 30535142; PMCID: PMC6324021.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    8. International Union of Basic and Clinical Pharmacology. CV. Somatostatin Receptors: Structure, Function, Ligands, and New Nomenclature. Pharmacol Rev. 2018 10; 70(4):763-835. G?nther T, Tulipano G, Dournaud P, Bousquet C, Csaba Z, Kreienkamp HJ, Lupp A, Korbonits M, Casta?o JP, Wester HJ, Culler M, Melmed S, Schulz S. PMID: 30232095; PMCID: PMC6148080.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    9. A Consensus Statement on acromegaly therapeutic outcomes. Nat Rev Endocrinol. 2018 09; 14(9):552-561. Melmed S, Bronstein MD, Chanson P, Klibanski A, Casanueva FF, Wass JAH, Strasburger CJ, Luger A, Clemmons DR, Giustina A. PMID: 30050156; PMCID: PMC7136157.
      View in: PubMed   Mentions: 133     Fields:    Translation:Humans
    10. THYMIC CARCINOID WITH ADRENOCORTICOTROPIC HORMONE-PRODUCING ECTOPIC CUSHING SYNDROME AND EMPTY SELLA. AACE Clin Case Rep. 2018 Sep-Oct; 4(5):e375-e378. Labadzhyan A, Kim SM, Rhyu J, Araki T, Mahtabifard A, Melmed S. PMID: 31897433; PMCID: PMC6939296.
      View in: PubMed   Mentions: 1  
    11. Long-Term Endocrine Outcomes Following Endoscopic Endonasal Transsphenoidal Surgery for Acromegaly and Associated Prognostic Factors. Neurosurgery. 2017 Aug 01; 81(2):357-366. Babu H, Ortega A, Nuno M, Dehghan A, Schweitzer A, Bonert HV, Carmichael JD, Cooper O, Melmed S, Mamelak AN. PMID: 28368500.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    12. Melvin M. Grumbach 1925-2016. Proc Natl Acad Sci U S A. 2017 05 09; 114(19):4845-4847. Melmed S. PMID: 28439029; PMCID: PMC5441730.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Altered Pituitary Gland Structure and Function in Posttraumatic Stress Disorder. J Endocr Soc. 2017 Jun 01; 1(6):577-587. Cooper O, Bonert V, Moser F, Mirocha J, Melmed S. PMID: 29264511; PMCID: PMC5686623.
      View in: PubMed   Mentions: 7  
    14. Somatostatin and dopamine receptor regulation of pituitary somatotroph adenomas. Pituitary. 2017 Feb; 20(1):93-99. Ben-Shlomo A, Liu NA, Melmed S. PMID: 27900635.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    15. Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2016 Nov; 101(11):3888-3921. Fleseriu M, Hashim IA, Karavitaki N, Melmed S, Murad MH, Salvatori R, Samuels MH. PMID: 27736313.
      View in: PubMed   Mentions: 194     Fields:    Translation:Humans
    16. Growth hormone is permissive for neoplastic colon growth. Proc Natl Acad Sci U S A. 2016 Jun 07; 113(23):E3250-9. Chesnokova V, Zonis S, Zhou C, Recouvreux MV, Ben-Shlomo A, Araki T, Barrett R, Workman M, Wawrowsky K, Ljubimov VA, Uhart M, Melmed S. PMID: 27226307; PMCID: PMC4988562.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    17. Pituitary Medicine From Discovery to Patient-Focused Outcomes. J Clin Endocrinol Metab. 2016 Mar; 101(3):769-77. Melmed S. PMID: 26908107; PMCID: PMC4803158.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    18. New therapeutic agents for acromegaly. Nat Rev Endocrinol. 2016 Feb; 12(2):90-8. Melmed S. PMID: 26610414.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    19. Cyclin E-Mediated Human Proopiomelanocortin Regulation as a Therapeutic Target for Cushing Disease. J Clin Endocrinol Metab. 2015 Jul; 100(7):2557-64. Liu NA, Araki T, Cuevas-Ramos D, Hong J, Ben-Shlomo A, Tone Y, Tone M, Melmed S. PMID: 25942479; PMCID: PMC5393529.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    20. Pituitary tumors. Endocrinol Metab Clin North Am. 2015 Mar; 44(1):1-9. Melmed S. PMID: 25732636; PMCID: PMC4351794.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    21. Safety and efficacy of oral octreotide in acromegaly: results of a multicenter phase III trial. J Clin Endocrinol Metab. 2015 Apr; 100(4):1699-708. Melmed S, Popovic V, Bidlingmaier M, Mercado M, van der Lely AJ, Biermasz N, Bolanowski M, Coculescu M, Schopohl J, Racz K, Glaser B, Goth M, Greenman Y, Trainer P, Mezosi E, Shimon I, Giustina A, Korbonits M, Bronstein MD, Kleinberg D, Teichman S, Gliko-Kabir I, Mamluk R, Haviv A, Strasburger C. PMID: 25664604.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCTClinical Trials
    22. A structural and functional acromegaly classification. J Clin Endocrinol Metab. 2015 Jan; 100(1):122-31. Cuevas-Ramos D, Carmichael JD, Cooper O, Bonert VS, Gertych A, Mamelak AN, Melmed S. PMID: 25250634; PMCID: PMC4283008.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    23. ErbB receptor-driven prolactinomas respond to targeted lapatinib treatment in female transgenic mice. Endocrinology. 2015 Jan; 156(1):71-9. Liu X, Kano M, Araki T, Cooper O, Fukuoka H, Tone Y, Tone M, Melmed S. PMID: 25375038; PMCID: PMC4272404.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    24. Acromegaly: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2014 Nov; 99(11):3933-51. Katznelson L, Laws ER, Melmed S, Molitch ME, Murad MH, Utz A, Wass JA, Endocrine Society. PMID: 25356808.
      View in: PubMed   Mentions: 467     Fields:    Translation:Humans
    25. Acromegaly: assessing the disorder and navigating therapeutic options for treatment. Endocr Pract. 2014 Oct; 20 Suppl 1:7-17; quiz 18-20. Melmed S, Kleinberg DL, Bonert V, Fleseriu M. PMID: 25374336.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    26. Challenges in life sciences and health systems in the 21st century. Croat Med J. 2014 Jun 01; 55(3):184-5. Melmed S, Vari SG. PMID: 24891276; PMCID: PMC4049212.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    27. Acromegaly clinical trial methodology impact on reported biochemical efficacy rates of somatostatin receptor ligand treatments: a meta-analysis. J Clin Endocrinol Metab. 2014 May; 99(5):1825-33. Carmichael JD, Bonert VS, Nu?o M, Ly D, Melmed S. PMID: 24606084; PMCID: PMC4010703.
      View in: PubMed   Mentions: 56     Fields:    Translation:Humans
    28. Constitutive somatostatin receptor subtype-3 signaling suppresses growth hormone synthesis. Mol Endocrinol. 2014 Apr; 28(4):554-64. Eigler T, Ben-Shlomo A, Zhou C, Khalafi R, Ren SG, Melmed S. PMID: 24606125; PMCID: PMC3968402.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    29. Sca1? murine pituitary adenoma cells show tumor-growth advantage. Endocr Relat Cancer. 2014 Apr; 21(2):203-16. Donangelo I, Ren SG, Eigler T, Svendsen C, Melmed S. PMID: 24481638; PMCID: PMC3978815.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    30. Single-surgeon fully endoscopic endonasal transsphenoidal surgery: outcomes in three-hundred consecutive cases. Pituitary. 2013 Sep; 16(3):393-401. Mamelak AN, Carmichael J, Bonert VH, Cooper O, Melmed S. PMID: 23011322.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    31. Growth hormone is a cellular senescence target in pituitary and nonpituitary cells. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):E3331-9. Chesnokova V, Zhou C, Ben-Shlomo A, Zonis S, Tani Y, Ren SG, Melmed S. PMID: 23940366; PMCID: PMC3761588.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    32. Constitutive somatostatin receptor subtype 2 activity attenuates GH synthesis. Endocrinology. 2013 Jul; 154(7):2399-409. Ben-Shlomo A, Pichurin O, Khalafi R, Zhou C, Chesnokova V, Ren SG, Liu NA, Melmed S. PMID: 23696564; PMCID: PMC3689284.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    33. Idiopathic adult growth hormone deficiency. J Clin Endocrinol Metab. 2013 Jun; 98(6):2187-97. Melmed S. PMID: 23539718; PMCID: PMC3667267.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    34. Clusterin and FOXL2 act concordantly to regulate pituitary gonadotroph adenoma growth. Mol Endocrinol. 2012 Dec; 26(12):2092-103. Chesnokova V, Zonis S, Wawrowsky K, Tani Y, Ben-Shlomo A, Ljubimov V, Mamelak A, Bannykh S, Melmed S. PMID: 23051594; PMCID: PMC3517712.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    35. Estradiol partially recapitulates murine pituitary cell cycle response to pregnancy. Endocrinology. 2012 Oct; 153(10):5011-22. Toledano Y, Zonis S, Ren SG, Wawrowsky K, Chesnokova V, Melmed S. PMID: 22851678; PMCID: PMC3512024.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    36. Somatostatin analogs and chimeric somatostatin-dopamine molecules differentially regulate human growth hormone and prolactin gene expression and secretion in vitro. Mol Cell Endocrinol. 2012 Oct 15; 362(1-2):104-9. Gruszka A, Culler MD, Melmed S. PMID: 22705877.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    37. Genomic characterization of human and rat prolactinomas. Endocrinology. 2012 Aug; 153(8):3679-91. Tong Y, Zheng Y, Zhou J, Oyesiku NM, Koeffler HP, Melmed S. PMID: 22635680; PMCID: PMC3404356.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    38. Subclinical hyperfunctioning pituitary adenomas: the silent tumors. Best Pract Res Clin Endocrinol Metab. 2012 Aug; 26(4):447-60. Cooper O, Melmed S. PMID: 22863387; PMCID: PMC3412996.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    39. EGFR as a therapeutic target for human, canine, and mouse ACTH-secreting pituitary adenomas. J Clin Invest. 2011 Dec; 121(12):4712-21. Fukuoka H, Cooper O, Ben-Shlomo A, Mamelak A, Ren SG, Bruyette D, Melmed S. PMID: 22105169; PMCID: PMC3226010.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimalsCells
    40. Expression and function of ErbB receptors and ligands in the pituitary. Endocr Relat Cancer. 2011 Oct; 18(6):R197-211. Cooper O, Vlotides G, Fukuoka H, Greene MI, Melmed S. PMID: 21917845; PMCID: PMC3758362.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimals
    41. PTTG1 attenuates drug-induced cellular senescence. PLoS One. 2011; 6(8):e23754. Tong Y, Zhao W, Zhou C, Wawrowsky K, Melmed S. PMID: 21858218; PMCID: PMC3157437.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    42. Targeting zebrafish and murine pituitary corticotroph tumors with a cyclin-dependent kinase (CDK) inhibitor. Proc Natl Acad Sci U S A. 2011 May 17; 108(20):8414-9. Liu NA, Jiang H, Ben-Shlomo A, Wawrowsky K, Fan XM, Lin S, Melmed S. PMID: 21536883; PMCID: PMC3100964.
      View in: PubMed   Mentions: 53     Fields:    Translation:Animals
    43. Lineage-specific restraint of pituitary gonadotroph cell adenoma growth. PLoS One. 2011 Mar 25; 6(3):e17924. Chesnokova V, Zonis S, Zhou C, Ben-Shlomo A, Wawrowsky K, Toledano Y, Tong Y, Kovacs K, Scheithauer B, Melmed S. PMID: 21464964; PMCID: PMC3064664.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    44. Pathogenesis of pituitary tumors. Nat Rev Endocrinol. 2011 May; 7(5):257-66. Melmed S. PMID: 21423242.
      View in: PubMed   Mentions: 167     Fields:    Translation:HumansAnimals
    45. HER2/ErbB2 receptor signaling in rat and human prolactinoma cells: strategy for targeted prolactinoma therapy. Mol Endocrinol. 2011 Jan; 25(1):92-103. Fukuoka H, Cooper O, Mizutani J, Tong Y, Ren SG, Bannykh S, Melmed S. PMID: 21106881; PMCID: PMC3089034.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    46. Silent corticogonadotroph adenomas: clinical and cellular characteristics and long-term outcomes. Horm Cancer. 2010 Apr; 1(2):80-92. Cooper O, Ben-Shlomo A, Bonert V, Bannykh S, Mirocha J, Melmed S. PMID: 20717480; PMCID: PMC2921667.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    47. Pituitary senescence: the evolving role of Pttg. Mol Cell Endocrinol. 2010 Sep 15; 326(1-2):55-9. Chesnokova V, Melmed S. PMID: 20153804; PMCID: PMC2906651.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    48. Pathogenesis of pituitary tumors. Prog Brain Res. 2010; 182:207-27. Yu R, Melmed S. PMID: 20541667.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    49. Acromegaly pathogenesis and treatment. J Clin Invest. 2009 Nov; 119(11):3189-202. Melmed S. PMID: 19884662; PMCID: PMC2769196.
      View in: PubMed   Mentions: 221     Fields:    Translation:HumansAnimalsCells
    50. E2F1 induces pituitary tumor transforming gene (PTTG1) expression in human pituitary tumors. Mol Endocrinol. 2009 Dec; 23(12):2000-12. Zhou C, Wawrowsky K, Bannykh S, Gutman S, Melmed S. PMID: 19837943; PMCID: PMC2796149.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    51. Rapid and sustained reduction of serum growth hormone and insulin-like growth factor-1 in patients with acromegaly receiving lanreotide Autogel therapy: a randomized, placebo-controlled, multicenter study with a 52 week open extension. Pituitary. 2010; 13(1):18-28. Melmed S, Cook D, Schopohl J, Goth MI, Lam KS, Marek J. PMID: 19639415; PMCID: PMC2807598.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    52. Pituitary tumour-transforming gene (PTTG) and pituitary senescence. Horm Res. 2009 Apr; 71 Suppl 2:82-7. Chesnokova V, Melmed S. PMID: 19407503.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    53. Heregulin regulates prolactinoma gene expression. Cancer Res. 2009 May 15; 69(10):4209-16. Vlotides G, Cooper O, Chen YH, Ren SG, Greenman Y, Melmed S. PMID: 19401448; PMCID: PMC2688701.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    54. Fibroblast growth factor-2 autofeedback regulation in pituitary folliculostellate TtT/GF cells. Endocrinology. 2009 Jul; 150(7):3252-8. Vlotides G, Chen YH, Eigler T, Ren SG, Melmed S. PMID: 19359387; PMCID: PMC2703553.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    55. Constitutive somatostatin receptor activity determines tonic pituitary cell response. Mol Endocrinol. 2009 Mar; 23(3):337-48. Ben-Shlomo A, Zhou C, Pichurin O, Chesnokova V, Liu NA, Culler MD, Melmed S. PMID: 19131507; PMCID: PMC2725764.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    56. The utility of oral glucose tolerance testing for diagnosis and assessment of treatment outcomes in 166 patients with acromegaly. J Clin Endocrinol Metab. 2009 Feb; 94(2):523-7. Carmichael JD, Bonert VS, Mirocha JM, Melmed S. PMID: 19033371.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    57. p21(Cip1) restrains pituitary tumor growth. Proc Natl Acad Sci U S A. 2008 Nov 11; 105(45):17498-503. Chesnokova V, Zonis S, Kovacs K, Ben-Shlomo A, Wawrowsky K, Bannykh S, Melmed S. PMID: 18981426; PMCID: PMC2577704.
      View in: PubMed   Mentions: 54     Fields:    Translation:Animals
    58. Rat prolactinoma cell growth regulation by epidermal growth factor receptor ligands. Cancer Res. 2008 Aug 01; 68(15):6377-86. Vlotides G, Siegel E, Donangelo I, Gutman S, Ren SG, Melmed S. PMID: 18676863; PMCID: PMC2497431.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    59. Lipodystrophy in patients with acromegaly receiving pegvisomant. J Clin Endocrinol Metab. 2008 Sep; 93(9):3515-8. Bonert VS, Kennedy L, Petersenn S, Barkan A, Carmichael J, Melmed S. PMID: 18611977.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    60. Oct-1 induces pituitary tumor transforming gene expression in endocrine tumors. Endocr Relat Cancer. 2008 Sep; 15(3):817-31. Zhou C, Tong Y, Wawrowsky K, Bannykh S, Donangelo I, Melmed S. PMID: 18550719; PMCID: PMC3123374.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    61. In vivo time-lapse imaging delineates the zebrafish pituitary proopiomelanocortin lineage boundary regulated by FGF3 signal. Dev Biol. 2008 Jul 15; 319(2):192-200. Liu NA, Ren M, Song J, Ríos Y, Wawrowsky K, Ben-Shlomo A, Lin S, Melmed S. PMID: 18514643; PMCID: PMC2583244.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    62. Acromegaly. Endocrinol Metab Clin North Am. 2008 Mar; 37(1):101-22, viii. Ben-Shlomo A, Melmed S. PMID: 18226732; PMCID: PMC2697616.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    63. Ovarian hyperstimulation syndrome caused by an FSH-secreting pituitary adenoma. Nat Clin Pract Endocrinol Metab. 2008 Apr; 4(4):234-8. Cooper O, Geller JL, Melmed S. PMID: 18268519; PMCID: PMC2777809.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    64. Anti-aging therapy with human growth hormone associated with metastatic colon cancer in a patient with Crohn's colitis. Clin Gastroenterol Hepatol. 2008 Mar; 6(3):360-3. Melmed GY, Devlin SM, Vlotides G, Dhall D, Ross S, Yu R, Melmed S. PMID: 18255351; PMCID: PMC2696478.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    65. Update in pituitary disease. J Clin Endocrinol Metab. 2008 Feb; 93(2):331-8. Melmed S. PMID: 18258780.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    66. Pasireotide--a somatostatin analog for the potential treatment of acromegaly, neuroendocrine tumors and Cushing's disease. IDrugs. 2007 Dec; 10(12):885-95. Ben-Shlomo A, Melmed S. PMID: 18041687.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    67. Somatostatin agonists for treatment of acromegaly. Mol Cell Endocrinol. 2008 May 14; 286(1-2):192-8. Ben-Shlomo A, Melmed S. PMID: 18191325; PMCID: PMC2697610.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    68. Senescence mediates pituitary hypoplasia and restrains pituitary tumor growth. Cancer Res. 2007 Nov 01; 67(21):10564-72. Chesnokova V, Zonis S, Rubinek T, Yu R, Ben-Shlomo A, Kovacs K, Wawrowsky K, Melmed S. PMID: 17975001; PMCID: PMC2770267.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    69. Regulation of growth hormone and prolactin gene expression and secretion by chimeric somatostatin-dopamine molecules. Endocrinology. 2007 Dec; 148(12):6107-14. Gruszka A, Ren SG, Dong J, Culler MD, Melmed S. PMID: 17656461.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    70. Discordant proliferation and differentiation in pituitary tumor-transforming gene-null bone marrow stem cells. Am J Physiol Cell Physiol. 2007 Sep; 293(3):C1082-92. Rubinek T, Chesnokova V, Wolf I, Wawrowsky K, Vlotides G, Melmed S. PMID: 17626243.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    71. Pituitary tumor-transforming gene: physiology and implications for tumorigenesis. Endocr Rev. 2007 Apr; 28(2):165-86. Vlotides G, Eigler T, Melmed S. PMID: 17325339.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansAnimalsCells
    72. Medical progress: Acromegaly. N Engl J Med. 2006 Dec 14; 355(24):2558-73. Melmed S. PMID: 17167139.
      View in: PubMed   Mentions: 362     Fields:    Translation:Humans
    73. Aryl hydrocarbon receptor interacting protein variants in sporadic pituitary adenomas. J Clin Endocrinol Metab. 2006 Dec; 91(12):5126-9. Yu R, Bonert V, Saporta I, Raffel LJ, Melmed S. PMID: 17018653.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    74. Murine pituitary tumor-transforming gene functions as a securin protein in insulin-secreting cells. J Endocrinol. 2006 Oct; 191(1):45-53. Yu R, Cruz-Soto M, Li Calzi S, Hui H, Melmed S. PMID: 17065388.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    75. Acromegaly with moderate hyperprolactinemia caused by an intrasellar macroadenoma. Nat Clin Pract Endocrinol Metab. 2006 Jul; 2(7):408-12; quiz following 412. Bonert VS, Melmed S. PMID: 16932323.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    76. Pituitary tumor transforming gene overexpression facilitates pituitary tumor development. Endocrinology. 2006 Oct; 147(10):4781-91. Donangelo I, Gutman S, Horvath E, Kovacs K, Wawrowsky K, Mount M, Melmed S. PMID: 16809444.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    77. Pyridoxal phosphate inhibits pituitary cell proliferation and hormone secretion. Endocrinology. 2006 Aug; 147(8):3936-42. Ren SG, Melmed S. PMID: 16690808; PMCID: PMC1513048.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    78. Cyclin-dependent kinase inhibitor gene polymorphisms in pituitary gigantism. Endocrine. 2006 Feb; 29(1):119-20. Yu R, Bonert V, Cruz-Soto M, Melmed S. PMID: 16622299.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    79. Implication of pituitary tropic status on tumor development. Front Horm Res. 2006; 35:1-8. Donangelo I, Melmed S. PMID: 16809918.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    80. Prolactin receptor signaling mediates the osmotic response of embryonic zebrafish lactotrophs. Mol Endocrinol. 2006 Apr; 20(4):871-80. Liu NA, Liu Q, Wawrowsky K, Yang Z, Lin S, Melmed S. PMID: 16339273.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    81. Treatment of acromegaly: future. Endocrine. 2005 Oct; 28(1):123-8. Donangelo I, Melmed S. PMID: 16311419.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    82. A novel molecular marker of pituitary tumor transforming gene involves in a rat liver regeneration. J Surg Res. 2005 Nov; 129(1):142-6. Akino K, Akita S, Mizuguchi T, Takumi I, Yu R, Wang XY, Rozga J, Demetriou AA, Melmed S, Ohtsuru A, Yamashita S. PMID: 15936773.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    83. Pituitary hypoplasia in Pttg-/- mice is protective for Rb+/- pituitary tumorigenesis. Mol Endocrinol. 2005 Sep; 19(9):2371-9. Chesnokova V, Kovacs K, Castro AV, Zonis S, Melmed S. PMID: 15919720; PMCID: PMC1201444.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    84. A critical analysis of pituitary tumor shrinkage during primary medical therapy in acromegaly. J Clin Endocrinol Metab. 2005 Jul; 90(7):4405-10. Melmed S, Sternberg R, Cook D, Klibanski A, Chanson P, Bonert V, Vance ML, Rhew D, Kleinberg D, Barkan A. PMID: 15827109.
      View in: PubMed   Mentions: 56     Fields:    Translation:Humans
    85. Early multipotential pituitary focal hyperplasia in the alpha-subunit of glycoprotein hormone-driven pituitary tumor-transforming gene transgenic mice. Mol Endocrinol. 2005 May; 19(5):1383-91. Abbud RA, Takumi I, Barker EM, Ren SG, Chen DY, Wawrowsky K, Melmed S. PMID: 15677710.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimals
    86. Body mass index determines evoked growth hormone (GH) responsiveness in normal healthy male subjects: diagnostic caveat for adult GH deficiency. J Clin Endocrinol Metab. 2004 Jul; 89(7):3397-401. Bonert VS, Elashoff JD, Barnett P, Melmed S. PMID: 15240621.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    87. The novel somatostatin ligand (SOM230) regulates human and rat anterior pituitary hormone secretion. J Clin Endocrinol Metab. 2004 Jun; 89(6):3027-32. Murray RD, Kim K, Ren SG, Lewis I, Weckbecker G, Bruns C, Melmed S. PMID: 15181094.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    88. Molecular targets in pituitary tumours. Nat Rev Cancer. 2004 Apr; 4(4):285-95. Heaney AP, Melmed S. PMID: 15057288.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    89. Pituitary tumor transforming gene: an update. Front Horm Res. 2004; 32:175-85. Yu R, Melmed S. PMID: 15281346.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    90. Mechanisms for pituitary tumorigenesis: the plastic pituitary. J Clin Invest. 2003 Dec; 112(11):1603-18. Melmed S. PMID: 14660734; PMCID: PMC281651.
      View in: PubMed   Mentions: 151     Fields:    Translation:HumansAnimals
    91. Suppression of rat and human growth hormone and prolactin secretion by a novel somatostatin/dopaminergic chimeric ligand. J Clin Endocrinol Metab. 2003 Nov; 88(11):5414-21. Ren SG, Kim S, Taylor J, Dong J, Moreau JP, Culler MD, Melmed S. PMID: 14602782.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    92. Cell-specific pituitary gene expression profiles after treatment with leukemia inhibitory factor reveal novel modulators for proopiomelanocortin expression. Endocrinology. 2004 Feb; 145(2):867-80. Abbud RA, Kelleher R, Melmed S. PMID: 14576184.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    93. Functional association of somatostatin receptor subtypes 2 and 5 in inhibiting human growth hormone secretion. J Clin Endocrinol Metab. 2003 Sep; 88(9):4239-45. Ren SG, Taylor J, Dong J, Yu R, Culler MD, Melmed S. PMID: 12970293.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    94. Overexpressed pituitary tumor-transforming gene causes aneuploidy in live human cells. Endocrinology. 2003 Nov; 144(11):4991-8. Yu R, Lu W, Chen J, McCabe CJ, Melmed S. PMID: 12960092.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    95. PPAR-gamma receptor ligands: novel therapy for pituitary adenomas. J Clin Invest. 2003 May; 111(9):1381-8. Heaney AP, Fernando M, Melmed S. PMID: 12727930; PMCID: PMC154441.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    96. Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic beta cell proliferation and diabetes. Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6):3428-32. Wang Z, Moro E, Kovacs K, Yu R, Melmed S. PMID: 12626748; PMCID: PMC152309.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    97. Clinical review 154: The role of pharmacotherapy in perioperative management of patients with acromegaly. J Clin Endocrinol Metab. 2003 Mar; 88(3):963-8. Ben-Shlomo A, Melmed S. PMID: 12629068.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    98. Pituitary corticotroph ontogeny and regulation in transgenic zebrafish. Mol Endocrinol. 2003 May; 17(5):959-66. Liu NA, Huang H, Yang Z, Herzog W, Hammerschmidt M, Lin S, Melmed S. PMID: 12576489.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    99. Leukemia inhibitory factor regulates prolactin secretion in prolactinoma and lactotroph cells. J Clin Endocrinol Metab. 2003 Feb; 88(2):858-63. Ben-Shlomo A, Miklovsky I, Ren SG, Yong WH, Heaney AP, Culler MD, Melmed S. PMID: 12574225.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    100. Human pituitary tumor-transforming gene (PTTG1) motif suppresses prolactin expression. Mol Endocrinol. 2003 Apr; 17(4):600-9. Horwitz GA, Miklovsky I, Heaney AP, Ren SG, Melmed S. PMID: 12554778.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    101. Expression and function of pituitary tumour transforming gene for T-lymphocyte activation. Br J Haematol. 2002 Dec; 119(4):1070-4. Stoika R, Melmed S. PMID: 12472590.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    102. Functional PPAR-gamma receptor is a novel therapeutic target for ACTH-secreting pituitary adenomas. Nat Med. 2002 Nov; 8(11):1281-7. Heaney AP, Fernando M, Yong WH, Melmed S. PMID: 12379847.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimals
    103. Minireview: Neuro-immuno-endocrine modulation of the hypothalamic-pituitary-adrenal (HPA) axis by gp130 signaling molecules. Endocrinology. 2002 May; 143(5):1571-4. Chesnokova V, Melmed S. PMID: 11956136.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimals
    104. Opposing effects of pituitary leukemia inhibitory factor and SOCS-3 on the ACTH axis response to inflammation. Am J Physiol Endocrinol Metab. 2002 May; 282(5):E1110-8. Chesnokova V, Kariagina A, Melmed S. PMID: 11934677.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    105. Functional role of estrogen in pituitary tumor pathogenesis. J Clin Invest. 2002 Jan; 109(2):277-83. Heaney AP, Fernando M, Melmed S. PMID: 11805140; PMCID: PMC150842.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimals
    106. Current status and future opportunities for controlling acromegaly. Pituitary. 2002; 5(3):185-96. Melmed S, Vance ML, Barkan AL, Bengtsson BA, Kleinberg D, Klibanski A, Trainer PJ. PMID: 12812311.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    107. The neurofibromatosis gene in human pituitary adenomas. Endocr Pathol. 1994 Dec; 5(4):229-232. Pei L, Melmed S. PMID: 32138455.
      View in: PubMed   Mentions: 1     Fields:    
    108. Clonality of endocrine tumors. Endocr Pathol. 1991 Jun; 2(2):61-63. Herman V, Melmed S. PMID: 32357607.
      View in: PubMed   Mentions:    Fields:    
    109. Hypothalamic hormonal regulation of human growth hormone gene expression in somatotroph adenoma cell cultures. Endocr Pathol. 1990 Dec; 1(4):236-244. Herman V, Weiss M, Becker D, Melmed S. PMID: 32357615.
      View in: PubMed   Mentions:    Fields:    
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