Shlomo K Melmed

Title(s)Professor-in-Residence, Medicine
SchoolMedicine
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    1. Reply to 'Tumour fibrosis in dopamine agonist-exposed prolactinomas is a diminishing concern'. Nat Rev Endocrinol. 2024 Mar 20. Petersenn S, Fleseriu M, Melmed S. PMID: 38509200.
      View in: PubMed   Mentions:    Fields:    
    2. A proposed clinical classification for pituitary neoplasms to guide therapy and prognosis. Lancet Diabetes Endocrinol. 2024 Jan 29. Ho KKY, Fleseriu M, Wass J, Katznelson L, Raverot G, Little AS, Castaño JP, Reincke M, Lopes MB, Kaiser UB, Chanson P, Gadelha M, Melmed S. PMID: 38301678.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Reply to 'The shift of therapeutic strategy for prolactinomas: surgery as the first-line option'. Nat Rev Endocrinol. 2024 Jan 22. Petersenn S, Fleseriu M, Melmed S. PMID: 38253862.
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    4. A fond farewell. Pituitary. 2024 Feb; 27(1):1-2. Melmed S. PMID: 38170372.
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    5. Author Correction: Diagnosis and management of prolactin-secreting pituitary adenomas: a Pituitary Society international Consensus Statement. Nat Rev Endocrinol. 2024 Jan; 20(1):62. Petersenn S, Fleseriu M, Casanueva FF, Giustina A, Biermasz N, Biller BMK, Bronstein M, Chanson P, Fukuoka H, Gadelha M, Greenman Y, Gurnell M, Ho KKY, Honegger J, Ioachimescu AG, Kaiser UB, Karavitaki N, Katznelson L, Lodish M, Maiter D, Marcus HJ, McCormack A, Molitch M, Muir CA, Neggers S, Pereira AM, Pivonello R, Post K, Raverot G, Salvatori R, Samson SL, Shimon I, Spencer-Segal J, Vila G, Wass J, Melmed S. PMID: 37848631.
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    6. Correction: consensus on criteria for acromegaly diagnosis and remission. Pituitary. 2024 Feb; 27(1):88. Giustina A, Biermasz N, Casanueva FF, Fleseriu M, Mortini P, Strasburger C, van der Lely AJ, Wass J, Melmed S, Acromegaly Consensus Group. PMID: 38052967; PMCID: PMC10837242.
      View in: PubMed   Mentions: 2     Fields:    
    7. Consensus on criteria for acromegaly diagnosis and remission. Pituitary. 2024 Feb; 27(1):7-22. Giustina A, Biermasz N, Casanueva FF, Fleseriu M, Mortini P, Strasburger C, van der Lely AJ, Wass J, Melmed S, Acromegaly Consensus Group. PMID: 37923946; PMCID: PMC10837217.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. WIP1 is a novel specific target for growth hormone action. iScience. 2023 Nov 17; 26(11):108117. Apaydin T, Zonis S, Zhou C, Valencia CW, Barrett R, Strous GJ, Mol JA, Chesnokova V, Melmed S. PMID: 37876819; PMCID: PMC10590974.
      View in: PubMed   Mentions:
    9. The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors. Br J Pharmacol. 2023 Oct; 180 Suppl 2:S23-S144. Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA, Abbracchio MP, Abraham G, Agoulnik A, Alexander W, Al-Hosaini K, Bäck M, Baker JG, Barnes NM, Bathgate R, Beaulieu JM, Beck-Sickinger AG, Behrens M, Bernstein KE, Bettler B, Birdsall NJM, Blaho V, Boulay F, Bousquet C, Bräuner-Osborne H, Burnstock G, Caló G, Castaño JP, Catt KJ, Ceruti S, Chazot P, Chiang N, Chini B, Chun J, Cianciulli A, Civelli O, Clapp LH, Couture R, Cox HM, Csaba Z, Dahlgren C, Dent G, Douglas SD, Dournaud P, Eguchi S, Escher E, Filardo EJ, Fong T, Fumagalli M, Gainetdinov RR, Garelja ML, de Gasparo M, Gerard C, Gershengorn M, Gobeil F, Goodfriend TL, Goudet C, Grätz L, Gregory KJ, Gundlach AL, Hamann J, Hanson J, Hauger RL, Hay DL, Heinemann A, Herr D, Hollenberg MD, Holliday ND, Horiuchi M, Hoyer D, Hunyady L, Husain A, IJzerman AP, Inagami T, Jacobson KA, Jensen RT, Jockers R, Jonnalagadda D, Karnik S, Kaupmann K, Kemp J, Kennedy C, Kihara Y, Kitazawa T, Kozielewicz P, Kreienkamp HJ, Kukkonen JP, Langenhan T, Larhammar D, Leach K, Lecca D, Lee JD, Leeman SE, Leprince J, Li XX, Lolait SJ, Lupp A, Macrae R, Maguire J, Malfacini D, Mazella J, McArdle CA, Melmed S, Michel MC, Miller LJ, Mitolo V, Mouillac B, Müller CE, Murphy PM, Nahon JL, Ngo T, Norel X, Nyimanu D, O'Carroll AM, Offermanns S, Panaro MA, Parmentier M, Pertwee RG, Pin JP, Prossnitz ER, Quinn M, Ramachandran R, Ray M, Reinscheid RK, Rondard P, Rovati GE, Ruzza C, Sanger GJ, Schöneberg T, Schulte G, Schulz S, Segaloff DL, Serhan CN, Singh KD, Smith CM, Stoddart LA, Sugimoto Y, Summers R, Tan VP, Thal D, Thomas WW, Timmermans PBMWM, Tirupula K, Toll L, Tulipano G, Unal H, Unger T, Valant C, Vanderheyden P, Vaudry D, Vaudry H, Vilardaga JP, Walker CS, Wang JM, Ward DT, Wester HJ, Willars GB, Williams TL, Woodruff TM, Yao C, Ye RD. PMID: 38123151.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    10. Diagnosis and management of prolactin-secreting pituitary adenomas: a Pituitary Society international Consensus Statement. Nat Rev Endocrinol. 2023 Dec; 19(12):722-740. Petersenn S, Fleseriu M, Casanueva FF, Giustina A, Biermasz N, Biller BMK, Bronstein M, Chanson P, Fukuoka H, Gadelha M, Greenman Y, Gurnell M, Ho KKY, Honegger J, Ioachimescu AG, Kaiser UB, Karavitaki N, Katznelson L, Lodish M, Maiter D, Marcus HJ, McCormack A, Molitch M, Muir CA, Neggers S, Pereira AM, Pivonello R, Post K, Raverot G, Salvatori R, Samson SL, Shimon I, Spencer-Segal J, Vila G, Wass J, Melmed S. PMID: 37670148.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    11. Pilot study to define criteria for Pituitary Tumors Centers of Excellence (PTCOE): results of an audit of leading international centers. Pituitary. 2023 Oct; 26(5):583-596. Giustina A, Uygur MM, Frara S, Barkan A, Biermasz NR, Chanson P, Freda P, Gadelha M, Kaiser UB, Lamberts S, Laws E, Nachtigall LB, Popovic V, Reincke M, Strasburger C, van der Lely AJ, Wass JAH, Melmed S, Casanueva FF. PMID: 37640885; PMCID: PMC10539196.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    12. Treatment Patterns, Adherence, Persistence, and Health Care Resource Utilization in Acromegaly: A Real-World Analysis. J Endocr Soc. 2023 Aug 28; 7(10):bvad104. Fleseriu M, Barkan A, Brue T, Duquesne E, Houchard A, Del Pilar Schneider M, Ribeiro-Oliveira A, Melmed S. PMID: 37705695; PMCID: PMC10496868.
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    13. Pituitary adenoma or neuroendocrine tumour: the need for an integrated prognostic classification. Nat Rev Endocrinol. 2023 Nov; 19(11):671-678. Ho KKY, Kaiser UB, Chanson P, Gadelha M, Wass J, Nieman L, Little A, Aghi MK, Raetzman L, Post K, Raverot G, Borowsky AD, Erickson D, Castaño JP, Laws ER, Zatelli MC, Sisco J, Esserman L, Yuen KCJ, Reincke M, Melmed S. PMID: 37592077.
      View in: PubMed   Mentions: 1     Fields:    
    14. Key Device Attributes for Injectable Somatostatin Receptor Ligand Therapy in Acromegaly and Neuroendocrine Tumours. Adv Ther. 2023 10; 40(10):4675-4688. Jørgensen JOL, de Herder WW, Martin WA, Kolarova T, Marks M, Follin C, Geilvoet W, Melmed S. PMID: 37573277.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. An individualized approach to the management of Cushing disease. Nat Rev Endocrinol. 2023 10; 19(10):581-599. Fleseriu M, Varlamov EV, Hinojosa-Amaya JM, Langlois F, Melmed S. PMID: 37537306.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Non-pituitary GH regulation of the tissue microenvironment. Endocr Relat Cancer. 2023 07 01; 30(7). Chesnokova V, Melmed S. PMID: 37066857; PMCID: PMC10247477.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    17. Generation of isogenic and homozygous MEN1 mutant cell lines from patient-derived iPSCs using CRISPR/Cas9. Stem Cell Res. 2023 06; 69:103124. Even-Zohar N, Metin-Armagan D, Ben-Shlomo A, Sareen D, Melmed S. PMID: 37209468; PMCID: PMC10882434.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    18. Treatment of Cushing Disease With Pituitary-Targeting Seliciclib. J Clin Endocrinol Metab. 2023 02 15; 108(3):726-735. Liu NA, Ben-Shlomo A, Carmichael JD, Wang C, Swerdloff RS, Heaney AP, Barkhoudarian G, Kelly D, Noureddin M, Lu L, Desai M, Stolyarov Y, Yuen K, Mamelak AN, Mirocha J, Tighiouart M, Melmed S. PMID: 36214832; PMCID: PMC10210614.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    19. Molecular targets in acromegaly. Front Endocrinol (Lausanne). 2022; 13:1068061. Labadzhyan A, Melmed S. PMID: 36545335; PMCID: PMC9760705.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    20. Clinical Biology of the Pituitary Adenoma. Endocr Rev. 2022 Nov 25; 43(6):1003-1037. Melmed S, Kaiser UB, Lopes MB, Bertherat J, Syro LV, Raverot G, Reincke M, Johannsson G, Beckers A, Fleseriu M, Giustina A, Wass JAH, Ho KKY. PMID: 35395078; PMCID: PMC9695123.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    21. Durable biochemical response and safety with oral octreotide capsules in acromegaly. Eur J Endocrinol. 2022 Dec 01; 187(6):733-741. Samson SL, Nachtigall LB, Fleseriu M, Jensterle M, Manning PJ, Elenkova A, Molitch ME, Ludlam WH, Patou G, Haviv A, Biermasz NR, Giustina A, Strasburger CJ, Kennedy L, Melmed S. PMID: 36173649; PMCID: PMC9641789.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    22. Acromegaly: pathogenesis, diagnosis, and management. Lancet Diabetes Endocrinol. 2022 11; 10(11):804-826. Fleseriu M, Langlois F, Lim DST, Varlamov EV, Melmed S. PMID: 36209758.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    23. Is GH Replacement for Adult GH Deficiency Safe? J Clin Endocrinol Metab. 2022 09 28; 107(10):e4238-e4239. Melmed S. PMID: 35552733; PMCID: PMC9516130.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    24. Endocrine Autoantibodies Determine Immune Checkpoint Inhibitor-induced Endocrinopathy: A Prospective Study. J Clin Endocrinol Metab. 2022 06 16; 107(7):1976-1982. Labadzhyan A, Wentzel K, Hamid O, Chow K, Kim S, Piro L, Melmed S. PMID: 35303106; PMCID: PMC9202695.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    25. Osilodrostat for the treatment of Cushing's disease: efficacy, stability, and persistence - Authors' reply. Lancet Diabetes Endocrinol. 2022 06; 10(6):385-387. Fleseriu M, Castinetti F, Gadelha M, Giustina A, Lacroix A, Melmed S, Newell-Price J, Pivonello R, Reincke M, Biller BMK, “Consensus on diagnosis and management of Cushing's disease: a guideline update”. PMID: 35597255.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    26. The NETting of pituitary adenoma: a gland illusion. Pituitary. 2022 06; 25(3):349-351. Ho KKY, Gadelha M, Kaiser UB, Reincke M, Melmed S. PMID: 35616761; PMCID: PMC9170656.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    27. Safety of growth hormone replacement in survivors of cancer and intracranial and pituitary tumours: a consensus statement. Eur J Endocrinol. 2022 04 21; 186(6):P35-P52. Boguszewski MCS, Boguszewski CL, Chemaitilly W, Cohen LE, Gebauer J, Higham C, Hoffman AR, Polak M, Yuen KCJ, Alos N, Antal Z, Bidlingmaier M, Biller BMK, Brabant G, Choong CSY, Cianfarani S, Clayton PE, Coutant R, Cardoso-Demartini AA, Fernandez A, Grimberg A, Guðmundsson K, Guevara-Aguirre J, Ho KKY, Horikawa R, Isidori AM, Jørgensen JOL, Kamenicky P, Karavitaki N, Kopchick JJ, Lodish M, Luo X, McCormack AI, Meacham L, Melmed S, Mostoufi Moab S, Müller HL, Neggers SJCMM, Aguiar Oliveira MH, Ozono K, Pennisi PA, Popovic V, Radovick S, Savendahl L, Touraine P, van Santen HM, Johannsson G. PMID: 35319491; PMCID: PMC9066587.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    28. Dural Invasion as a Marker of Aggressive Pituitary Adenomas. Neurosurgery. 2022 06 01; 90(6):775-783. Cooper O, Bonert V, Mamelak AN, Bannykh S, Melmed S. PMID: 35262532; PMCID: PMC9514742.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    29. The pituitary tumour-transforming gene 1/delta-like homologue 1 pathway plays a key role in liver fibrogenesis. Liver Int. 2022 03; 42(3):651-662. Perramón M, Carvajal S, Reichenbach V, Fernández-Varo G, Boix L, Macias-Muñoz L, Melgar-Lesmes P, Bruix J, Melmed S, Lamas S, Jiménez W. PMID: 35050550; PMCID: PMC9303549.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    30. Pituitary Somatotroph Adenoma-derived Exosomes: Characterization of Nonhormonal Actions. J Clin Endocrinol Metab. 2022 01 18; 107(2):379-397. Zhou C, Shen S, Moran R, Deng N, Marbán E, Melmed S. PMID: 34467411; PMCID: PMC8764361.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    31. Prevalence of comorbidities and concomitant medication use in acromegaly: analysis of real-world data from the United States. Pituitary. 2022 Apr; 25(2):296-307. Fleseriu M, Barkan A, Del Pilar Schneider M, Darhi Y, de Pierrefeu A, Ribeiro-Oliveira A, Petersenn S, Neggers S, Melmed S. PMID: 34973139; PMCID: PMC8894179.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    32. Maintenance of response to oral octreotide compared with injectable somatostatin receptor ligands in patients with acromegaly: a phase 3, multicentre, randomised controlled trial. Lancet Diabetes Endocrinol. 2022 02; 10(2):102-111. Fleseriu M, Dreval A, Bondar I, Vagapova G, Macut D, Pokramovich YG, Molitch ME, Leonova N, Raverot G, Grineva E, Poteshkin YE, Gilgun-Sherki Y, Ludlam WH, Patou G, Haviv A, Gordon MB, Biermasz NR, Melmed S, Strasburger CJ. PMID: 34953531.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    33. Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage. Cell Rep. 2021 12 14; 37(11):110068. Chesnokova V, Zonis S, Apostolou A, Estrada HQ, Knott S, Wawrowsky K, Michelsen K, Ben-Shlomo A, Barrett R, Gorbunova V, Karalis K, Melmed S. PMID: 34910915; PMCID: PMC8716125.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    34. GH and Senescence: A New Understanding of Adult GH Action. J Endocr Soc. 2022 Jan 01; 6(1):bvab177. Chesnokova V, Melmed S. PMID: 34909519; PMCID: PMC8664681.
      View in: PubMed   Mentions: 3  
    35. International Multicenter Validation Study of the SAGIT® Instrument in Acromegaly. J Clin Endocrinol Metab. 2021 11 19; 106(12):3555-3568. Giustina A, Bronstein MD, Chanson P, Petersenn S, Casanueva FF, Sert C, Houchard A, Melmed S. PMID: 34313752.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    36. Consensus on diagnosis and management of Cushing's disease: a guideline update. Lancet Diabetes Endocrinol. 2021 12; 9(12):847-875. Fleseriu M, Auchus R, Bancos I, Ben-Shlomo A, Bertherat J, Biermasz NR, Boguszewski CL, Bronstein MD, Buchfelder M, Carmichael JD, Casanueva FF, Castinetti F, Chanson P, Findling J, Gadelha M, Geer EB, Giustina A, Grossman A, Gurnell M, Ho K, Ioachimescu AG, Kaiser UB, Karavitaki N, Katznelson L, Kelly DF, Lacroix A, McCormack A, Melmed S, Molitch M, Mortini P, Newell-Price J, Nieman L, Pereira AM, Petersenn S, Pivonello R, Raff H, Reincke M, Salvatori R, Scaroni C, Shimon I, Stratakis CA, Swearingen B, Tabarin A, Takahashi Y, Theodoropoulou M, Tsagarakis S, Valassi E, Varlamov EV, Vila G, Wass J, Webb SM, Zatelli MC, Biller BMK. PMID: 34687601; PMCID: PMC8743006.
      View in: PubMed   Mentions: 145     Fields:    Translation:Humans
    37. THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors. Br J Pharmacol. 2021 Oct; 178 Suppl 1:S27-S156. Alexander SP, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Abbracchio MP, Alexander W, Al-Hosaini K, Bäck M, Barnes NM, Bathgate R, Beaulieu JM, Bernstein KE, Bettler B, Birdsall NJM, Blaho V, Boulay F, Bousquet C, Bräuner-Osborne H, Burnstock G, Caló G, Castaño JP, Catt KJ, Ceruti S, Chazot P, Chiang N, Chini B, Chun J, Cianciulli A, Civelli O, Clapp LH, Couture R, Csaba Z, Dahlgren C, Dent G, Singh KD, Douglas SD, Dournaud P, Eguchi S, Escher E, Filardo EJ, Fong T, Fumagalli M, Gainetdinov RR, Gasparo M, Gerard C, Gershengorn M, Gobeil F, Goodfriend TL, Goudet C, Gregory KJ, Gundlach AL, Hamann J, Hanson J, Hauger RL, Hay DL, Heinemann A, Hollenberg MD, Holliday ND, Horiuchi M, Hoyer D, Hunyady L, Husain A, IJzerman AP, Inagami T, Jacobson KA, Jensen RT, Jockers R, Jonnalagadda D, Karnik S, Kaupmann K, Kemp J, Kennedy C, Kihara Y, Kitazawa T, Kozielewicz P, Kreienkamp HJ, Kukkonen JP, Langenhan T, Leach K, Lecca D, Lee JD, Leeman SE, Leprince J, Li XX, Williams TL, Lolait SJ, Lupp A, Macrae R, Maguire J, Mazella J, McArdle CA, Melmed S, Michel MC, Miller LJ, Mitolo V, Mouillac B, Müller CE, Murphy P, Nahon JL, Ngo T, Norel X, Nyimanu D, O'Carroll AM, Offermanns S, Panaro MA, Parmentier M, Pertwee RG, Pin JP, Prossnitz ER, Quinn M, Ramachandran R, Ray M, Reinscheid RK, Rondard P, Rovati GE, Ruzza C, Sanger GJ, Schöneberg T, Schulte G, Schulz S, Segaloff DL, Serhan CN, Stoddart LA, Sugimoto Y, Summers R, Tan VP, Thal D, Thomas WW, Timmermans PBMWM, Tirupula K, Tulipano G, Unal H, Unger T, Valant C, Vanderheyden P, Vaudry D, Vaudry H, Vilardaga JP, Walker CS, Wang JM, Ward DT, Wester HJ, Willars GB, Woodruff TM, Yao C, Ye RD. PMID: 34529832.
      View in: PubMed   Mentions: 130     Fields:    Translation:Humans
    38. Two Distinctive POMC Promoters Modify Gene Expression in Cushing Disease. J Clin Endocrinol Metab. 2021 08 18; 106(9):e3346-e3363. Araki T, Tone Y, Yamamoto M, Kameda H, Ben-Shlomo A, Yamada S, Takeshita A, Yamamoto M, Kawakami Y, Tone M, Melmed S. PMID: 34061962; PMCID: PMC8372657.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    39. Insulin-like Growth Factor 1 and Prolactin Levels in Chimpanzees (Pan troglodytes) Across the Lifespan. J Endocr Soc. 2021 Aug 01; 5(8):bvab063. Ben-Shlomo A, McLachlan SM, Hwe J, Aliesky H, Hasselschwert D, Mirocha J, Melmed S. PMID: 34235358; PMCID: PMC8256382.
      View in: PubMed   Mentions:
    40. Pituitary stem cells. Vitam Horm. 2021; 116:1-19. Even-Zohar N, Metin Armagan D, Melmed S. PMID: 33752816.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    41. Pituitary Neoplasm Nomenclature Workshop: Does Adenoma Stand the Test of Time? J Endocr Soc. 2021 Mar 01; 5(3):bvaa205. Ho K, Fleseriu M, Kaiser U, Salvatori R, Brue T, Lopes MB, Kunz P, Molitch M, Camper SA, Gadelha M, Syro LV, Laws E, Reincke M, Nishioka H, Grossman A, Barkan A, Casanueva F, Wass J, Mamelak A, Katznelson L, van der Lely AJ, Radovick S, Bidlingmaier M, Boguszewski M, Bollerslev J, Hoffman AR, Oyesiku N, Raverot G, Ben-Shlomo A, Fowkes R, Shimon I, Fukuoka H, Pereira AM, Greenman Y, Heaney AP, Gurnell M, Johannsson G, Osamura RY, Buchfelder M, Zatelli MC, Korbonits M, Chanson P, Biermasz N, Clemmons DR, Karavitaki N, Bronstein MD, Trainer P, Melmed S. PMID: 33604494; PMCID: PMC7874572.
      View in: PubMed   Mentions: 18  
    42. EGFR/ErbB2-Targeting Lapatinib Therapy for Aggressive Prolactinomas. J Clin Endocrinol Metab. 2021 01 23; 106(2):e917-e925. Cooper O, Bonert VS, Rudnick J, Pressman BD, Lo J, Salvatori R, Yuen KCJ, Fleseriu M, Melmed S. PMID: 33150390; PMCID: PMC7823257.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCTClinical Trials
    43. Prospective Evaluation of Incidental Pituitary Imaging Findings in the Sella Turcica. J Endocr Soc. 2021 Feb 01; 5(2):bvaa186. Kuo M, Maya MM, Bonert V, Melmed S. PMID: 33392424; PMCID: PMC7759030.
      View in: PubMed   Mentions: 6  
    44. DNA damage and growth hormone hypersecretion in pituitary somatotroph adenomas. J Clin Invest. 2020 11 02; 130(11):5738-5755. Ben-Shlomo A, Deng N, Ding E, Yamamoto M, Mamelak A, Chesnokova V, Labadzhyan A, Melmed S. PMID: 32673291; PMCID: PMC7598090.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    45. A Pituitary Society update to acromegaly management guidelines. Pituitary. 2021 Feb; 24(1):1-13. Fleseriu M, Biller BMK, Freda PU, Gadelha MR, Giustina A, Katznelson L, Molitch ME, Samson SL, Strasburger CJ, van der Lely AJ, Melmed S. PMID: 33079318; PMCID: PMC7864830.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimals
    46. Maintenance of Acromegaly Control in Patients Switching From Injectable Somatostatin Receptor Ligands to Oral Octreotide. J Clin Endocrinol Metab. 2020 10 01; 105(10). Samson SL, Nachtigall LB, Fleseriu M, Gordon MB, Bolanowski M, Labadzhyan A, Ur E, Molitch M, Ludlam WH, Patou G, Haviv A, Biermasz N, Giustina A, Trainer PJ, Strasburger CJ, Kennedy L, Melmed S. PMID: 32882036; PMCID: PMC7470473.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCTClinical Trials
    47. Pituitary Tumor Transforming Gene 1 Orchestrates Gene Regulatory Variation in Mouse Ventral Midbrain During Aging. Front Genet. 2020; 11:566734. Gui Y, Thomas MH, Garcia P, Karout M, Halder R, Michelucci A, Kollmus H, Zhou C, Melmed S, Schughart K, Balling R, Mittelbronn M, Nadeau JH, Williams RW, Sauter T, Buttini M, Sinkkonen L. PMID: 33173537; PMCID: PMC7538689.
      View in: PubMed   Mentions: 2  
    48. Multidisciplinary management of acromegaly: A consensus. Rev Endocr Metab Disord. 2020 12; 21(4):667-678. Giustina A, Barkhoudarian G, Beckers A, Ben-Shlomo A, Biermasz N, Biller B, Boguszewski C, Bolanowski M, Bollerslev J, Bonert V, Bronstein MD, Buchfelder M, Casanueva F, Chanson P, Clemmons D, Fleseriu M, Formenti AM, Freda P, Gadelha M, Geer E, Gurnell M, Heaney AP, Ho KKY, Ioachimescu AG, Lamberts S, Laws E, Losa M, Maffei P, Mamelak A, Mercado M, Molitch M, Mortini P, Pereira AM, Petersenn S, Post K, Puig-Domingo M, Salvatori R, Samson SL, Shimon I, Strasburger C, Swearingen B, Trainer P, Vance ML, Wass J, Wierman ME, Yuen KCJ, Zatelli MC, Melmed S. PMID: 32914330; PMCID: PMC7942783.
      View in: PubMed   Mentions: 98     Fields:    Translation:Humans
    49. Cost-Effectiveness and Efficacy of a Novel Combination Regimen in Acromegaly: A Prospective, Randomized Trial. J Clin Endocrinol Metab. 2020 09 01; 105(9). Bonert V, Mirocha J, Carmichael J, Yuen KCJ, Araki T, Melmed S. PMID: 32754748.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    50. The tale in evolution: clarity, consistency and consultation, not contradiction and confusion. Pituitary. 2020 08; 23(4):476-477. Ho KKY, Fleseriu M, Wass J, van der Lely A, Barkan A, Giustina A, Casanueva FF, Heaney AP, Biermasz N, Strasburger C, Melmed S. PMID: 31912348.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    51. Peptide Hormone Regulation of DNA Damage Responses. Endocr Rev. 2020 07 01; 41(4). Chesnokova V, Melmed S. PMID: 32270196; PMCID: PMC7279704.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    52. A Consensus on the Diagnosis and Treatment of Acromegaly Comorbidities: An Update. J Clin Endocrinol Metab. 2020 04 01; 105(4). Giustina A, Barkan A, Beckers A, Biermasz N, Biller BMK, Boguszewski C, Bolanowski M, Bonert V, Bronstein MD, Casanueva FF, Clemmons D, Colao A, Ferone D, Fleseriu M, Frara S, Gadelha MR, Ghigo E, Gurnell M, Heaney AP, Ho K, Ioachimescu A, Katznelson L, Kelestimur F, Kopchick J, Krsek M, Lamberts S, Losa M, Luger A, Maffei P, Marazuela M, Mazziotti G, Mercado M, Mortini P, Neggers S, Pereira AM, Petersenn S, Puig-Domingo M, Salvatori R, Shimon I, Strasburger C, Tsagarakis S, van der Lely AJ, Wass J, Zatelli MC, Melmed S. PMID: 31606735.
      View in: PubMed   Mentions: 91     Fields:    Translation:Humans
    53. Pituitary-Tumor Endocrinopathies. N Engl J Med. 2020 03 05; 382(10):937-950. Melmed S. PMID: 32130815.
      View in: PubMed   Mentions: 170     Fields:    Translation:Humans
    54. A tale of pituitary adenomas: to NET or not to NET : Pituitary Society position statement. Pituitary. 2019 12; 22(6):569-573. Ho KKY, Fleseriu M, Wass J, van der Lely A, Barkan A, Giustina A, Casanueva FF, Heaney AP, Biermasz N, Strasburger C, Melmed S. PMID: 31571098.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    55. Growth hormone in the tumor microenvironment. Arch Endocrinol Metab. 2019 Nov-Dec; 63(6):568-575. Chesnokova V, Melmed S. PMID: 31939481; PMCID: PMC7025769.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    56. Author Correction: Acromegaly. Nat Rev Dis Primers. 2019 Oct 21; 5(1):72. Colao A, Grasso LFS, Giustina A, Melmed S, Chanson P, Pereira AM, Pivonello R. PMID: 31636262.
      View in: PubMed   Mentions: 2     Fields:    
    57. Staging and managing patients with acromegaly in clinical practice: baseline data from the SAGIT® validation study. Pituitary. 2019 Oct; 22(5):476-487. Giustina A, Bronstein MD, Chanson P, Petersenn S, Casanueva FF, Sert C, Houchard A, Melmed S. PMID: 31338660; PMCID: PMC6728296.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    58. Pathogenesis and Diagnosis of Growth Hormone Deficiency in Adults. N Engl J Med. 2019 06 27; 380(26):2551-2562. Melmed S. PMID: 31242363.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    59. Growth Hormone Induces Colon DNA Damage Independent of IGF-1. Endocrinology. 2019 06 01; 160(6):1439-1447. Chesnokova V, Zonis S, Barrett RJ, Gleeson JP, Melmed S. PMID: 31002310; PMCID: PMC6530523.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    60. Acromegaly. Nat Rev Dis Primers. 2019 03 21; 5(1):20. Colao A, Grasso LFS, Giustina A, Melmed S, Chanson P, Pereira AM, Pivonello R. PMID: 30899019.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansPHPublic Health
    61. Excess growth hormone suppresses DNA damage repair in epithelial cells. JCI Insight. 2019 Feb 07; 4(3). Chesnokova V, Zonis S, Barrett R, Kameda H, Wawrowsky K, Ben-Shlomo A, Yamamoto M, Gleeson J, Bresee C, Gorbunova V, Melmed S. PMID: 30728323; PMCID: PMC6413789.
      View in: PubMed   Mentions: 21     Fields:    
    62. Proton Sensitivity of Corticotropin-Releasing Hormone Receptor 1 Signaling to Proopiomelanocortin in Male Mice. Endocrinology. 2019 02 01; 160(2):276-291. Kameda H, Yamamoto M, Tone Y, Tone M, Melmed S. PMID: 30535142; PMCID: PMC6324021.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    63. Correction to: Criteria for the definition of Pituitary Tumor Centers of Excellence (PTCOE): A Pituitary Society Statement. Pituitary. 2018 12; 21(6):663. Casanueva FF, Barkan AL, Buchfelder M, Klibanski A, Laws ER, Loeffler JS, Melmed S, Mortini P, Wass J, Giustina A, Pituitary Society, Expert Group on Pituitary Tumors. PMID: 30238283; PMCID: PMC6828177.
      View in: PubMed   Mentions: 2     Fields:    
    64. Somatostatin receptor subtype 5 modifies hypothalamic-pituitary-adrenal axis stress function. JCI Insight. 2018 10 04; 3(19). Yamamoto M, Ben-Shlomo A, Kameda H, Fukuoka H, Deng N, Ding Y, Melmed S. PMID: 30282821; PMCID: PMC6237446.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    65. International Union of Basic and Clinical Pharmacology. CV. Somatostatin Receptors: Structure, Function, Ligands, and New Nomenclature. Pharmacol Rev. 2018 10; 70(4):763-835. Günther T, Tulipano G, Dournaud P, Bousquet C, Csaba Z, Kreienkamp HJ, Lupp A, Korbonits M, Castaño JP, Wester HJ, Culler M, Melmed S, Schulz S. PMID: 30232095; PMCID: PMC6148080.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    66. A Consensus Statement on acromegaly therapeutic outcomes. Nat Rev Endocrinol. 2018 09; 14(9):552-561. Melmed S, Bronstein MD, Chanson P, Klibanski A, Casanueva FF, Wass JAH, Strasburger CJ, Luger A, Clemmons DR, Giustina A. PMID: 30050156; PMCID: PMC7136157.
      View in: PubMed   Mentions: 179     Fields:    Translation:Humans
    67. THYMIC CARCINOID WITH ADRENOCORTICOTROPIC HORMONE-PRODUCING ECTOPIC CUSHING SYNDROME AND EMPTY SELLA. AACE Clin Case Rep. 2018 Sep-Oct; 4(5):e375-e378. Labadzhyan A, Kim SM, Rhyu J, Araki T, Mahtabifard A, Melmed S. PMID: 31897433; PMCID: PMC6939296.
      View in: PubMed   Mentions: 1  
    68. Criteria for the definition of Pituitary Tumor Centers of Excellence (PTCOE): A Pituitary Society Statement. Pituitary. 2017 Oct; 20(5):489-498. Casanueva FF, Barkan AL, Buchfelder M, Klibanski A, Laws ER, Loeffler JS, Melmed S, Mortini P, Wass J, Giustina A, Pituitary Society, Expert Group on Pituitary Tumors. PMID: 28884415; PMCID: PMC5606938.
      View in: PubMed   Mentions: 93     Fields:    Translation:Humans
    69. Long-Term Endocrine Outcomes Following Endoscopic Endonasal Transsphenoidal Surgery for Acromegaly and Associated Prognostic Factors. Neurosurgery. 2017 Aug 01; 81(2):357-366. Babu H, Ortega A, Nuno M, Dehghan A, Schweitzer A, Bonert HV, Carmichael JD, Cooper O, Melmed S, Mamelak AN. PMID: 28368500.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    70. Androgen Receptor Regulation of Local Growth Hormone in Prostate Cancer Cells. Endocrinology. 2017 07 01; 158(7):2255-2268. Recouvreux MV, Wu JB, Gao AC, Zonis S, Chesnokova V, Bhowmick N, Chung LW, Melmed S. PMID: 28444169; PMCID: PMC5505214.
      View in: PubMed   Mentions: 13     Fields:    
    71. Melvin M. Grumbach 1925-2016. Proc Natl Acad Sci U S A. 2017 05 09; 114(19):4845-4847. Melmed S. PMID: 28439029; PMCID: PMC5441730.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    72. Altered Pituitary Gland Structure and Function in Posttraumatic Stress Disorder. J Endocr Soc. 2017 Jun 01; 1(6):577-587. Cooper O, Bonert V, Moser F, Mirocha J, Melmed S. PMID: 29264511; PMCID: PMC5686623.
      View in: PubMed   Mentions: 7  
    73. Somatostatin and dopamine receptor regulation of pituitary somatotroph adenomas. Pituitary. 2017 Feb; 20(1):93-99. Ben-Shlomo A, Liu NA, Melmed S. PMID: 27900635.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    74. EGFR Induces E2F1-Mediated Corticotroph Tumorigenesis. J Endocr Soc. 2017 Feb 01; 1(2):127-143. Araki T, Liu X, Kameda H, Tone Y, Fukuoka H, Tone M, Melmed S. PMID: 29264472; PMCID: PMC5686559.
      View in: PubMed   Mentions: 24  
    75. Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2016 Nov; 101(11):3888-3921. Fleseriu M, Hashim IA, Karavitaki N, Melmed S, Murad MH, Salvatori R, Samuels MH. PMID: 27736313.
      View in: PubMed   Mentions: 257     Fields:    Translation:Humans
    76. E2F1-mediated human POMC expression in ectopic Cushing's syndrome. Endocr Relat Cancer. 2016 11; 23(11):857-870. Araki T, Liu NA, Tone Y, Cuevas-Ramos D, Heltsley R, Tone M, Melmed S. PMID: 27935805; PMCID: PMC5152695.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    77. Growth hormone is permissive for neoplastic colon growth. Proc Natl Acad Sci U S A. 2016 Jun 07; 113(23):E3250-9. Chesnokova V, Zonis S, Zhou C, Recouvreux MV, Ben-Shlomo A, Araki T, Barrett R, Workman M, Wawrowsky K, Ljubimov VA, Uhart M, Melmed S. PMID: 27226307; PMCID: PMC4988562.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    78. Treatment of clinically nonfunctioning pituitary adenomas with dopamine agonists. Eur J Endocrinol. 2016 Jul; 175(1):63-72. Greenman Y, Cooper O, Yaish I, Robenshtok E, Sagiv N, Jonas-Kimchi T, Yuan X, Gertych A, Shimon I, Ram Z, Melmed S, Stern N. PMID: 27150495.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    79. Growth Hormone Research Society perspective on the development of long-acting growth hormone preparations. Eur J Endocrinol. 2016 Jun; 174(6):C1-8. Christiansen JS, Backeljauw PF, Bidlingmaier M, Biller BM, Boguszewski MC, Casanueva FF, Chanson P, Chatelain P, Choong CS, Clemmons DR, Cohen LE, Cohen P, Frystyk J, Grimberg A, Hasegawa Y, Haymond MW, Ho K, Hoffman AR, Holly JM, Horikawa R, Höybye C, Jorgensen JO, Johannsson G, Juul A, Katznelson L, Kopchick JJ, Lee KO, Lee KW, Luo X, Melmed S, Miller BS, Misra M, Popovic V, Rosenfeld RG, Ross J, Ross RJ, Saenger P, Strasburger CJ, Thorner MO, Werner H, Yuen K. PMID: 27009113; PMCID: PMC5081743.
      View in: PubMed   Mentions: 50     Fields:    Translation:Humans
    80. Pituitary Medicine From Discovery to Patient-Focused Outcomes. J Clin Endocrinol Metab. 2016 Mar; 101(3):769-77. Melmed S. PMID: 26908107; PMCID: PMC4803158.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    81. SAGIT®: clinician-reported outcome instrument for managing acromegaly in clinical practice--development and results from a pilot study. Pituitary. 2016 Feb; 19(1):39-49. Giustina A, Bevan JS, Bronstein MD, Casanueva FF, Chanson P, Petersenn S, Thanh XM, Sert C, Houchard A, Guillemin I, Melmed S, SAGIT Investigator Group. PMID: 26377024; PMCID: PMC4710645.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    82. New therapeutic agents for acromegaly. Nat Rev Endocrinol. 2016 Feb; 12(2):90-8. Melmed S. PMID: 26610414.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    83. Endocrinology research-reflecting on the past decade and looking to the next. Nat Rev Endocrinol. 2015 Nov; 11(11):672-80. Herold KC, Majzoub JA, Melmed S, Pendergrass M, Schlumberger M. PMID: 26460340.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    84. Fertility and fragrance: another cause of Kallmann syndrome. J Clin Invest. 2015 Jun; 125(6):2275-8. Melmed S. PMID: 25985271; PMCID: PMC4497770.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    85. Cyclin E-Mediated Human Proopiomelanocortin Regulation as a Therapeutic Target for Cushing Disease. J Clin Endocrinol Metab. 2015 Jul; 100(7):2557-64. Liu NA, Araki T, Cuevas-Ramos D, Hong J, Ben-Shlomo A, Tone Y, Tone M, Melmed S. PMID: 25942479; PMCID: PMC5393529.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    86. STAT3 upregulation in pituitary somatotroph adenomas induces growth hormone hypersecretion. J Clin Invest. 2015 Apr; 125(4):1692-702. Zhou C, Jiao Y, Wang R, Ren SG, Wawrowsky K, Melmed S. PMID: 25774503; PMCID: PMC4396466.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    87. Pituitary tumors. Endocrinol Metab Clin North Am. 2015 Mar; 44(1):1-9. Melmed S. PMID: 25732636; PMCID: PMC4351794.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    88. Safety and efficacy of oral octreotide in acromegaly: results of a multicenter phase III trial. J Clin Endocrinol Metab. 2015 Apr; 100(4):1699-708. Melmed S, Popovic V, Bidlingmaier M, Mercado M, van der Lely AJ, Biermasz N, Bolanowski M, Coculescu M, Schopohl J, Racz K, Glaser B, Goth M, Greenman Y, Trainer P, Mezosi E, Shimon I, Giustina A, Korbonits M, Bronstein MD, Kleinberg D, Teichman S, Gliko-Kabir I, Mamluk R, Haviv A, Strasburger C. PMID: 25664604.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCTClinical Trials
    89. ErbB receptor-driven prolactinomas respond to targeted lapatinib treatment in female transgenic mice. Endocrinology. 2015 Jan; 156(1):71-9. Liu X, Kano M, Araki T, Cooper O, Fukuoka H, Tone Y, Tone M, Melmed S. PMID: 25375038; PMCID: PMC4272404.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    90. A structural and functional acromegaly classification. J Clin Endocrinol Metab. 2015 Jan; 100(1):122-31. Cuevas-Ramos D, Carmichael JD, Cooper O, Bonert VS, Gertych A, Mamelak AN, Melmed S. PMID: 25250634; PMCID: PMC4283008.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    91. Acromegaly: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2014 Nov; 99(11):3933-51. Katznelson L, Laws ER, Melmed S, Molitch ME, Murad MH, Utz A, Wass JA, Endocrine Society. PMID: 25356808.
      View in: PubMed   Mentions: 561     Fields:    Translation:Humans
    92. Sagit©: A Novel Clinician-Reported Outcome for Managing Acromegaly in Clinical Practice. Value Health. 2014 Nov; 17(7):A355. Giustina A, Bevan J, Bronstein M, Casanueva F, Chanson P, Petersenn S, Truong TX, Massien C, Dias-Barbosa C, Guillemin I, Arnould B, Melmed S. PMID: 27200705.
      View in: PubMed   Mentions: 1     Fields:    
    93. Endocrine Society 2014 Laureate Awards. Horm Cancer. 2014 Oct; 5(5):339-55. Gustafsson JA, Katzenellenbogen B, Jameson JL, Roth J, Melmed S, McDonnell D, Wartofsky L, Crowley WF, Griz LH, Becker C, Moore DD, Drucker D, Singh N, O'Malley B. PMID: 25091407; PMCID: PMC10358126.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    94. Acromegaly: assessing the disorder and navigating therapeutic options for treatment. Endocr Pract. 2014 Oct; 20 Suppl 1:7-17; quiz 18-20. Melmed S, Kleinberg DL, Bonert V, Fleseriu M. PMID: 25374336.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    95. Adult mortality or morbidity is not increased in childhood-onset growth hormone deficient patients who received pediatric GH treatment: an analysis of the Hypopituitary Control and Complications Study (HypoCCS). Pituitary. 2014 Oct; 17(5):477-85. Mo D, Hardin DS, Erfurth EM, Melmed S. PMID: 24122237; PMCID: PMC4159575.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    96. Pituitary tumor-transforming gene 1 regulates the patterning of retinal mosaics. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):9295-300. Keeley PW, Zhou C, Lu L, Williams RW, Melmed S, Reese BE. PMID: 24927528; PMCID: PMC4078852.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    97. Challenges in life sciences and health systems in the 21st century. Croat Med J. 2014 Jun 01; 55(3):184-5. Melmed S, Vari SG. PMID: 24891276; PMCID: PMC4049212.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    98. Long-term efficacy and safety of subcutaneous pasireotide in acromegaly: results from an open-ended, multicenter, Phase II extension study. Pituitary. 2014 Apr; 17(2):132-40. Petersenn S, Farrall AJ, De Block C, Block C, Melmed S, Schopohl J, Caron P, Cuneo R, Kleinberg D, Colao A, Ruffin M, Hermosillo Reséndiz K, Hughes G, Hu K, Barkan A. PMID: 23529827; PMCID: PMC3942632.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCTClinical Trials
    99. Clinical factors associated with biochemical adrenal-cortisol insufficiency in hospitalized patients. Am J Med. 2014 Aug; 127(8):754-762. Ben-Shlomo A, Mirocha J, Gwin SM, Khine AK, Liu NA, Sheinin RC, Melmed S. PMID: 24632056; PMCID: PMC4127354.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    100. Constitutive somatostatin receptor subtype-3 signaling suppresses growth hormone synthesis. Mol Endocrinol. 2014 Apr; 28(4):554-64. Eigler T, Ben-Shlomo A, Zhou C, Khalafi R, Ren SG, Melmed S. PMID: 24606125; PMCID: PMC3968402.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    101. Acromegaly clinical trial methodology impact on reported biochemical efficacy rates of somatostatin receptor ligand treatments: a meta-analysis. J Clin Endocrinol Metab. 2014 May; 99(5):1825-33. Carmichael JD, Bonert VS, Nuño M, Ly D, Melmed S. PMID: 24606084; PMCID: PMC4010703.
      View in: PubMed   Mentions: 60     Fields:    Translation:Humans
    102. Expert consensus document: A consensus on the medical treatment of acromegaly. Nat Rev Endocrinol. 2014 Apr; 10(4):243-8. Giustina A, Chanson P, Kleinberg D, Bronstein MD, Clemmons DR, Klibanski A, van der Lely AJ, Strasburger CJ, Lamberts SW, Ho KK, Casanueva FF, Melmed S, Acromegaly Consensus Group. PMID: 24566817.
      View in: PubMed   Mentions: 135     Fields:    Translation:Humans
    103. Sca1⁺ murine pituitary adenoma cells show tumor-growth advantage. Endocr Relat Cancer. 2014 Apr; 21(2):203-16. Donangelo I, Ren SG, Eigler T, Svendsen C, Melmed S. PMID: 24481638; PMCID: PMC3978815.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    104. Single-surgeon fully endoscopic endonasal transsphenoidal surgery: outcomes in three-hundred consecutive cases. Pituitary. 2013 Sep; 16(3):393-401. Mamelak AN, Carmichael J, Bonert VH, Cooper O, Melmed S. PMID: 23011322.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    105. A consensus on the diagnosis and treatment of acromegaly complications. Pituitary. 2013 Sep; 16(3):294-302. Melmed S, Casanueva FF, Klibanski A, Bronstein MD, Chanson P, Lamberts SW, Strasburger CJ, Wass JA, Giustina A. PMID: 22903574; PMCID: PMC3730092.
      View in: PubMed   Mentions: 120     Fields:    Translation:Humans
    106. Growth hormone is a cellular senescence target in pituitary and nonpituitary cells. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):E3331-9. Chesnokova V, Zhou C, Ben-Shlomo A, Zonis S, Tani Y, Ren SG, Melmed S. PMID: 23940366; PMCID: PMC3761588.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    107. Constitutive somatostatin receptor subtype 2 activity attenuates GH synthesis. Endocrinology. 2013 Jul; 154(7):2399-409. Ben-Shlomo A, Pichurin O, Khalafi R, Zhou C, Chesnokova V, Ren SG, Liu NA, Melmed S. PMID: 23696564; PMCID: PMC3689284.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    108. Idiopathic adult growth hormone deficiency. J Clin Endocrinol Metab. 2013 Jun; 98(6):2187-97. Melmed S. PMID: 23539718; PMCID: PMC3667267.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    109. PTTG acts as a STAT3 target gene for colorectal cancer cell growth and motility. Oncogene. 2014 Feb 13; 33(7):851-61. Zhou C, Tong Y, Wawrowsky K, Melmed S. PMID: 23416975; PMCID: PMC3930149.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    110. Prospective safety surveillance of GH-deficient adults: comparison of GH-treated vs untreated patients. J Clin Endocrinol Metab. 2013 Mar; 98(3):980-8. Hartman ML, Xu R, Crowe BJ, Robison LL, Erfurth EM, Kleinberg DL, Zimmermann AG, Woodmansee WW, Cutler GB, Chipman JJ, Melmed S, International HypoCCS Advisory Board. PMID: 23345098; PMCID: PMC3677286.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansPHPublic Health
    111. Clusterin and FOXL2 act concordantly to regulate pituitary gonadotroph adenoma growth. Mol Endocrinol. 2012 Dec; 26(12):2092-103. Chesnokova V, Zonis S, Wawrowsky K, Tani Y, Ben-Shlomo A, Ljubimov V, Mamelak A, Bannykh S, Melmed S. PMID: 23051594; PMCID: PMC3517712.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    112. Ectopic acromegaly due to growth hormone releasing hormone. Endocrine. 2013 Apr; 43(2):293-302. Ghazi AA, Amirbaigloo A, Dezfooli AA, Saadat N, Ghazi S, Pourafkari M, Tirgari F, Dhall D, Bannykh S, Melmed S, Cooper O. PMID: 22983831; PMCID: PMC3553305.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    113. A botulinum toxin-derived targeted secretion inhibitor downregulates the GH/IGF1 axis. J Clin Invest. 2012 Sep; 122(9):3295-306. Somm E, Bonnet N, Martinez A, Marks PM, Cadd VA, Elliott M, Toulotte A, Ferrari SL, Rizzoli R, Hüppi PS, Harper E, Melmed S, Jones R, Aubert ML. PMID: 22850878; PMCID: PMC3428092.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    114. Estradiol partially recapitulates murine pituitary cell cycle response to pregnancy. Endocrinology. 2012 Oct; 153(10):5011-22. Toledano Y, Zonis S, Ren SG, Wawrowsky K, Chesnokova V, Melmed S. PMID: 22851678; PMCID: PMC3512024.
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    115. Clinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1). J Clin Endocrinol Metab. 2012 Sep; 97(9):2990-3011. Thakker RV, Newey PJ, Walls GV, Bilezikian J, Dralle H, Ebeling PR, Melmed S, Sakurai A, Tonelli F, Brandi ML, Endocrine Society. PMID: 22723327.
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    116. Somatostatin analogs and chimeric somatostatin-dopamine molecules differentially regulate human growth hormone and prolactin gene expression and secretion in vitro. Mol Cell Endocrinol. 2012 Oct 15; 362(1-2):104-9. Gruszka A, Culler MD, Melmed S. PMID: 22705877.
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    117. Genomic characterization of human and rat prolactinomas. Endocrinology. 2012 Aug; 153(8):3679-91. Tong Y, Zheng Y, Zhou J, Oyesiku NM, Koeffler HP, Melmed S. PMID: 22635680; PMCID: PMC3404356.
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    118. Subclinical hyperfunctioning pituitary adenomas: the silent tumors. Best Pract Res Clin Endocrinol Metab. 2012 Aug; 26(4):447-60. Cooper O, Melmed S. PMID: 22863387; PMCID: PMC3412996.
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    119. Meta-analysis on the effects of octreotide on tumor mass in acromegaly. PLoS One. 2012; 7(5):e36411. Giustina A, Mazziotti G, Torri V, Spinello M, Floriani I, Melmed S. PMID: 22574156; PMCID: PMC3344864.
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    120. Oral octreotide absorption in human subjects: comparable pharmacokinetics to parenteral octreotide and effective growth hormone suppression. J Clin Endocrinol Metab. 2012 Jul; 97(7):2362-9. Tuvia S, Atsmon J, Teichman SL, Katz S, Salama P, Pelled D, Landau I, Karmeli I, Bidlingmaier M, Strasburger CJ, Kleinberg DL, Melmed S, Mamluk R. PMID: 22539587.
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    121. EGFR as a therapeutic target for human, canine, and mouse ACTH-secreting pituitary adenomas. J Clin Invest. 2011 Dec; 121(12):4712-21. Fukuoka H, Cooper O, Ben-Shlomo A, Mamelak A, Ren SG, Bruyette D, Melmed S. PMID: 22105169; PMCID: PMC3226010.
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    122. Expression and function of ErbB receptors and ligands in the pituitary. Endocr Relat Cancer. 2011 Oct; 18(6):R197-211. Cooper O, Vlotides G, Fukuoka H, Greene MI, Melmed S. PMID: 21917845; PMCID: PMC3758362.
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    123. CEBPD suppresses prolactin expression and prolactinoma cell proliferation. Mol Endocrinol. 2011 Nov; 25(11):1880-91. Tong Y, Zhou J, Mizutani J, Fukuoka H, Ren SG, Gutierrez-Hartmann A, Koeffler HP, Melmed S. PMID: 21980073; PMCID: PMC3198962.
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    124. Clinical, quality of life, and economic value of acromegaly disease control. Pituitary. 2011 Sep; 14(3):284-94. Ben-Shlomo A, Sheppard MC, Stephens JM, Pulgar S, Melmed S. PMID: 21597975; PMCID: PMC3146976.
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    125. PTTG1 attenuates drug-induced cellular senescence. PLoS One. 2011; 6(8):e23754. Tong Y, Zhao W, Zhou C, Wawrowsky K, Melmed S. PMID: 21858218; PMCID: PMC3157437.
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    126. Current management practices for acromegaly: an international survey. Pituitary. 2011 Jun; 14(2):125-33. Giustina A, Bronstein MD, Casanueva FF, Chanson P, Ghigo E, Ho KK, Klibanski A, Lamberts S, Trainer P, Melmed S. PMID: 21063787.
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    127. Targeting zebrafish and murine pituitary corticotroph tumors with a cyclin-dependent kinase (CDK) inhibitor. Proc Natl Acad Sci U S A. 2011 May 17; 108(20):8414-9. Liu NA, Jiang H, Ben-Shlomo A, Wawrowsky K, Fan XM, Lin S, Melmed S. PMID: 21536883; PMCID: PMC3100964.
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    128. Pituitary magnetic resonance imaging for sellar and parasellar masses: ten-year experience in 2598 patients. J Clin Endocrinol Metab. 2011 Jun; 96(6):1633-41. Famini P, Maya MM, Melmed S. PMID: 21470998; PMCID: PMC3100749.
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    129. Lineage-specific restraint of pituitary gonadotroph cell adenoma growth. PLoS One. 2011 Mar 25; 6(3):e17924. Chesnokova V, Zonis S, Zhou C, Ben-Shlomo A, Wawrowsky K, Toledano Y, Tong Y, Kovacs K, Scheithauer B, Melmed S. PMID: 21464964; PMCID: PMC3064664.
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    130. Pathogenesis of pituitary tumors. Nat Rev Endocrinol. 2011 May; 7(5):257-66. Melmed S. PMID: 21423242.
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    131. Patient guide to hyperprolactinemia diagnosis and treatment. J Clin Endocrinol Metab. 2011 Feb; 96(2):35A-6A. Hoffman AR, Melmed S, Schlechte J. PMID: 21296988.
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    132. Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011 Feb; 96(2):273-88. Melmed S, Casanueva FF, Hoffman AR, Kleinberg DL, Montori VM, Schlechte JA, Wass JA, Endocrine Society. PMID: 21296991.
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    133. Zebrafish usp39 mutation leads to rb1 mRNA splicing defect and pituitary lineage expansion. PLoS Genet. 2011 Jan 13; 7(1):e1001271. Ríos Y, Melmed S, Lin S, Liu NA. PMID: 21249182; PMCID: PMC3020934.
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    134. HER2/ErbB2 receptor signaling in rat and human prolactinoma cells: strategy for targeted prolactinoma therapy. Mol Endocrinol. 2011 Jan; 25(1):92-103. Fukuoka H, Cooper O, Mizutani J, Tong Y, Ren SG, Bannykh S, Melmed S. PMID: 21106881; PMCID: PMC3089034.
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    135. The endocrine tumor summit 2008: appraising therapeutic approaches for acromegaly and carcinoid syndrome. Pituitary. 2010 Sep; 13(3):266-86. Klibanski A, Melmed S, Clemmons DR, Colao A, Cunningham RS, Molitch ME, Vinik AI, Adelman DT, Liebert KJ. PMID: 20012914; PMCID: PMC2913001.
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    136. Molecular mechanisms of pituitary adenoma senescence. Front Horm Res. 2010; 38:7-14. Chesnokova V, Zonis S, Ben-Shlomo A, Wawrowsky K, Melmed S. PMID: 20616490.
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    137. Pasireotide (SOM230) demonstrates efficacy and safety in patients with acromegaly: a randomized, multicenter, phase II trial. J Clin Endocrinol Metab. 2010 Jun; 95(6):2781-9. Petersenn S, Schopohl J, Barkan A, Mohideen P, Colao A, Abs R, Buchelt A, Ho YY, Hu K, Farrall AJ, Melmed S, Biller BM, Pasireotide Acromegaly Study Group. PMID: 20410233.
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    138. A consensus on criteria for cure of acromegaly. J Clin Endocrinol Metab. 2010 Jul; 95(7):3141-8. Giustina A, Chanson P, Bronstein MD, Klibanski A, Lamberts S, Casanueva FF, Trainer P, Ghigo E, Ho K, Melmed S, Acromegaly Consensus Group. PMID: 20410227.
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    139. Silent corticogonadotroph adenomas: clinical and cellular characteristics and long-term outcomes. Horm Cancer. 2010 Apr; 1(2):80-92. Cooper O, Ben-Shlomo A, Bonert V, Bannykh S, Mirocha J, Melmed S. PMID: 20717480; PMCID: PMC2921667.
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    140. Pituitary senescence: the evolving role of Pttg. Mol Cell Endocrinol. 2010 Sep 15; 326(1-2):55-9. Chesnokova V, Melmed S. PMID: 20153804; PMCID: PMC2906651.
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    141. Pituitary somatostatin receptor signaling. Trends Endocrinol Metab. 2010 Mar; 21(3):123-33. Ben-Shlomo A, Melmed S. PMID: 20149677; PMCID: PMC2834886.
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    142. Constitutive activity of somatostatin receptor subtypes. Methods Enzymol. 2010; 484:149-64. Ben-Shlomo A, Wawrowsky K, Melmed S. PMID: 21036231.
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    143. Pathogenesis of pituitary tumors. Prog Brain Res. 2010; 182:207-27. Yu R, Melmed S. PMID: 20541667.
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    144. Metabolic, cardiovascular, and cerebrovascular outcomes in growth hormone-deficient subjects with previous cushing's disease or non-functioning pituitary adenoma. J Clin Endocrinol Metab. 2010 Feb; 95(2):630-8. Webb SM, Mo D, Lamberts SW, Melmed S, Cavagnini F, Pecori Giraldi F, Strasburger CJ, Zimmermann AG, Woodmansee WW, International HypoCCS Advisory Board. PMID: 20022992.
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    145. Differential Ligand-Mediated Pituitary Somatostatin Receptor Subtype Signaling: Implications for Corticotroph Tumor Therapy. Endocr Rev. 2009 Dec 01; 30(7):933. Ben-Shlomo A, Schmid H, Wawrowsky K, Pichurin O, Hubina E, Chesnokova V, Liu NA, Culler M, Melmed S. PMID: 28199544.
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    146. Acromegaly pathogenesis and treatment. J Clin Invest. 2009 Nov; 119(11):3189-202. Melmed S. PMID: 19884662; PMCID: PMC2769196.
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    147. E2F1 induces pituitary tumor transforming gene (PTTG1) expression in human pituitary tumors. Mol Endocrinol. 2009 Dec; 23(12):2000-12. Zhou C, Wawrowsky K, Bannykh S, Gutman S, Melmed S. PMID: 19837943; PMCID: PMC2796149.
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    148. Differential ligand-mediated pituitary somatostatin receptor subtype signaling: implications for corticotroph tumor therapy. J Clin Endocrinol Metab. 2009 Nov; 94(11):4342-50. Ben-Shlomo A, Schmid H, Wawrowsky K, Pichurin O, Hubina E, Chesnokova V, Liu NA, Culler M, Melmed S. PMID: 19820006.
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    149. Rapid and sustained reduction of serum growth hormone and insulin-like growth factor-1 in patients with acromegaly receiving lanreotide Autogel therapy: a randomized, placebo-controlled, multicenter study with a 52 week open extension. Pituitary. 2010; 13(1):18-28. Melmed S, Cook D, Schopohl J, Goth MI, Lam KS, Marek J. PMID: 19639415; PMCID: PMC2807598.
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    150. Pituitary tumour-transforming gene (PTTG) and pituitary senescence. Horm Res. 2009 Apr; 71 Suppl 2:82-7. Chesnokova V, Melmed S. PMID: 19407503.
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    151. Heregulin regulates prolactinoma gene expression. Cancer Res. 2009 May 15; 69(10):4209-16. Vlotides G, Cooper O, Chen YH, Ren SG, Greenman Y, Melmed S. PMID: 19401448; PMCID: PMC2688701.
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    152. Fibroblast growth factor-2 autofeedback regulation in pituitary folliculostellate TtT/GF cells. Endocrinology. 2009 Jul; 150(7):3252-8. Vlotides G, Chen YH, Eigler T, Ren SG, Melmed S. PMID: 19359387; PMCID: PMC2703553.
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    153. Pituitary adenoma growth: a model for cellular senescence and cytokine action. Cell Cycle. 2009 Mar 01; 8(5):677-8. Arzt E, Chesnokova V, Stalla GK, Melmed S. PMID: 19223763; PMCID: PMC2710531.
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    154. Guidelines for acromegaly management: an update. J Clin Endocrinol Metab. 2009 May; 94(5):1509-17. Melmed S, Colao A, Barkan A, Molitch M, Grossman AB, Kleinberg D, Clemmons D, Chanson P, Laws E, Schlechte J, Vance ML, Ho K, Giustina A, Acromegaly Consensus Group. PMID: 19208732.
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    155. Constitutive somatostatin receptor activity determines tonic pituitary cell response. Mol Endocrinol. 2009 Mar; 23(3):337-48. Ben-Shlomo A, Zhou C, Pichurin O, Chesnokova V, Liu NA, Culler MD, Melmed S. PMID: 19131507; PMCID: PMC2725764.
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    156. The utility of oral glucose tolerance testing for diagnosis and assessment of treatment outcomes in 166 patients with acromegaly. J Clin Endocrinol Metab. 2009 Feb; 94(2):523-7. Carmichael JD, Bonert VS, Mirocha JM, Melmed S. PMID: 19033371.
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    157. Changing patterns of the adult growth hormone deficiency diagnosis documented in a decade-long global surveillance database. J Clin Endocrinol Metab. 2009 Feb; 94(2):392-9. Webb SM, Strasburger CJ, Mo D, Hartman ML, Melmed S, Jung H, Blum WF, Attanasio AF, HypoCCS International Advisory Board. PMID: 19001512.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansPHPublic Health
    158. p21(Cip1) restrains pituitary tumor growth. Proc Natl Acad Sci U S A. 2008 Nov 11; 105(45):17498-503. Chesnokova V, Zonis S, Kovacs K, Ben-Shlomo A, Wawrowsky K, Bannykh S, Melmed S. PMID: 18981426; PMCID: PMC2577704.
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    159. Treatment of pituitary-dependent Cushing's disease with the multireceptor ligand somatostatin analog pasireotide (SOM230): a multicenter, phase II trial. J Clin Endocrinol Metab. 2009 Jan; 94(1):115-22. Boscaro M, Ludlam WH, Atkinson B, Glusman JE, Petersenn S, Reincke M, Snyder P, Tabarin A, Biller BM, Findling J, Melmed S, Darby CH, Hu K, Wang Y, Freda PU, Grossman AB, Frohman LA, Bertherat J. PMID: 18957506.
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    160. Guidelines for the treatment of growth hormone excess and growth hormone deficiency in adults. J Endocrinol Invest. 2008 Sep; 31(9):820-38. Giustina A, Barkan A, Chanson P, Grossman A, Hoffman A, Ghigo E, Casanueva F, Colao A, Lamberts S, Sheppard M, Melmed S, Pituitary Society, European Neuroendocrine Association. PMID: 18997495.
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    161. Rat prolactinoma cell growth regulation by epidermal growth factor receptor ligands. Cancer Res. 2008 Aug 01; 68(15):6377-86. Vlotides G, Siegel E, Donangelo I, Gutman S, Ren SG, Melmed S. PMID: 18676863; PMCID: PMC2497431.
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    162. Pituitary tumor transforming gene 1 regulates Aurora kinase A activity. Oncogene. 2008 Oct 23; 27(49):6385-95. Tong Y, Ben-Shlomo A, Zhou C, Wawrowsky K, Melmed S. PMID: 18663361.
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    163. Lipodystrophy in patients with acromegaly receiving pegvisomant. J Clin Endocrinol Metab. 2008 Sep; 93(9):3515-8. Bonert VS, Kennedy L, Petersenn S, Barkan A, Carmichael J, Melmed S. PMID: 18611977.
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    164. Oct-1 induces pituitary tumor transforming gene expression in endocrine tumors. Endocr Relat Cancer. 2008 Sep; 15(3):817-31. Zhou C, Tong Y, Wawrowsky K, Bannykh S, Donangelo I, Melmed S. PMID: 18550719; PMCID: PMC3123374.
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    165. A critical analysis of clinically available somatostatin analog formulations for therapy of acromegaly. J Clin Endocrinol Metab. 2008 Aug; 93(8):2957-68. Murray RD, Melmed S. PMID: 18477663.
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    166. Treatment of adrenocorticotropin-dependent Cushing's syndrome: a consensus statement. J Clin Endocrinol Metab. 2008 Jul; 93(7):2454-62. Biller BM, Grossman AB, Stewart PM, Melmed S, Bertagna X, Bertherat J, Buchfelder M, Colao A, Hermus AR, Hofland LJ, Klibanski A, Lacroix A, Lindsay JR, Newell-Price J, Nieman LK, Petersenn S, Sonino N, Stalla GK, Swearingen B, Vance ML, Wass JA, Boscaro M. PMID: 18413427; PMCID: PMC3214276.
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    167. In vivo time-lapse imaging delineates the zebrafish pituitary proopiomelanocortin lineage boundary regulated by FGF3 signal. Dev Biol. 2008 Jul 15; 319(2):192-200. Liu NA, Ren M, Song J, Ríos Y, Wawrowsky K, Ben-Shlomo A, Lin S, Melmed S. PMID: 18514643; PMCID: PMC2583244.
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    168. Acromegaly. Endocrinol Metab Clin North Am. 2008 Mar; 37(1):101-22, viii. Ben-Shlomo A, Melmed S. PMID: 18226732; PMCID: PMC2697616.
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    169. Ovarian hyperstimulation syndrome caused by an FSH-secreting pituitary adenoma. Nat Clin Pract Endocrinol Metab. 2008 Apr; 4(4):234-8. Cooper O, Geller JL, Melmed S. PMID: 18268519; PMCID: PMC2777809.
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    170. Anti-aging therapy with human growth hormone associated with metastatic colon cancer in a patient with Crohn's colitis. Clin Gastroenterol Hepatol. 2008 Mar; 6(3):360-3. Melmed GY, Devlin SM, Vlotides G, Dhall D, Ross S, Yu R, Melmed S. PMID: 18255351; PMCID: PMC2696478.
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    171. Update in pituitary disease. J Clin Endocrinol Metab. 2008 Feb; 93(2):331-8. Melmed S. PMID: 18258780.
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    172. Pasireotide--a somatostatin analog for the potential treatment of acromegaly, neuroendocrine tumors and Cushing's disease. IDrugs. 2007 Dec; 10(12):885-95. Ben-Shlomo A, Melmed S. PMID: 18041687.
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    173. Somatostatin agonists for treatment of acromegaly. Mol Cell Endocrinol. 2008 May 14; 286(1-2):192-8. Ben-Shlomo A, Melmed S. PMID: 18191325; PMCID: PMC2697610.
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    174. Senescence mediates pituitary hypoplasia and restrains pituitary tumor growth. Cancer Res. 2007 Nov 01; 67(21):10564-72. Chesnokova V, Zonis S, Rubinek T, Yu R, Ben-Shlomo A, Kovacs K, Wawrowsky K, Melmed S. PMID: 17975001; PMCID: PMC2770267.
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    175. Regulation of growth hormone and prolactin gene expression and secretion by chimeric somatostatin-dopamine molecules. Endocrinology. 2007 Dec; 148(12):6107-14. Gruszka A, Ren SG, Dong J, Culler MD, Melmed S. PMID: 17656461.
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    176. Discordant proliferation and differentiation in pituitary tumor-transforming gene-null bone marrow stem cells. Am J Physiol Cell Physiol. 2007 Sep; 293(3):C1082-92. Rubinek T, Chesnokova V, Wolf I, Wawrowsky K, Vlotides G, Melmed S. PMID: 17626243.
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    177. Selective regulation of somatostatin receptor subtype signaling: evidence for constitutive receptor activation. Mol Endocrinol. 2007 Oct; 21(10):2565-78. Ben-Shlomo A, Pichurin O, Barshop NJ, Wawrowsky KA, Taylor J, Culler MD, Chesnokova V, Liu NA, Melmed S. PMID: 17609435.
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    178. Aryl hydrocarbon receptor interacting protein and pituitary tumorigenesis: another interesting protein. J Clin Endocrinol Metab. 2007 May; 92(5):1617-9. Melmed S. PMID: 17483376.
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    179. Pituitary tumor transforming gene interacts with Sp1 to modulate G1/S cell phase transition. Oncogene. 2007 Aug 16; 26(38):5596-605. Tong Y, Tan Y, Zhou C, Melmed S. PMID: 17353909; PMCID: PMC2736684.
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    180. Pituitary tumor-transforming gene: physiology and implications for tumorigenesis. Endocr Rev. 2007 Apr; 28(2):165-86. Vlotides G, Eigler T, Melmed S. PMID: 17325339.
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    181. Medical progress: Acromegaly. N Engl J Med. 2006 Dec 14; 355(24):2558-73. Melmed S. PMID: 17167139.
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    182. Aryl hydrocarbon receptor interacting protein variants in sporadic pituitary adenomas. J Clin Endocrinol Metab. 2006 Dec; 91(12):5126-9. Yu R, Bonert V, Saporta I, Raffel LJ, Melmed S. PMID: 17018653.
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    183. Murine pituitary tumor-transforming gene functions as a securin protein in insulin-secreting cells. J Endocrinol. 2006 Oct; 191(1):45-53. Yu R, Cruz-Soto M, Li Calzi S, Hui H, Melmed S. PMID: 17065388.
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    184. Mechanisms for growth factor-induced pituitary tumor transforming gene-1 expression in pituitary folliculostellate TtT/GF cells. Mol Endocrinol. 2006 Dec; 20(12):3321-35. Vlotides G, Cruz-Soto M, Rubinek T, Eigler T, Auernhammer CJ, Melmed S. PMID: 16959877.
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    185. Skin manifestations in acromegaly. Clin Dermatol. 2006 Jul-Aug; 24(4):256-9. Ben-Shlomo A, Melmed S. PMID: 16828406.
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    186. Acromegaly with moderate hyperprolactinemia caused by an intrasellar macroadenoma. Nat Clin Pract Endocrinol Metab. 2006 Jul; 2(7):408-12; quiz following 412. Bonert VS, Melmed S. PMID: 16932323.
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    187. Pituitary tumor transforming gene overexpression facilitates pituitary tumor development. Endocrinology. 2006 Oct; 147(10):4781-91. Donangelo I, Gutman S, Horvath E, Kovacs K, Wawrowsky K, Mount M, Melmed S. PMID: 16809444.
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    188. Sex-steroid milieu determines diabetes rescue in pttg-null mice. J Endocrinol. 2006 Jun; 189(3):519-28. Fraenkel M, Caloyeras J, Ren SG, Melmed S. PMID: 16731783.
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    189. Pyridoxal phosphate inhibits pituitary cell proliferation and hormone secretion. Endocrinology. 2006 Aug; 147(8):3936-42. Ren SG, Melmed S. PMID: 16690808; PMCID: PMC1513048.
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    190. Elucidating the murine brain transcriptional network in a segregating mouse population to identify core functional modules for obesity and diabetes. J Neurochem. 2006 Apr; 97 Suppl 1:50-62. Lum PY, Chen Y, Zhu J, Lamb J, Melmed S, Wang S, Drake TA, Lusis AJ, Schadt EE. PMID: 16635250.
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    191. Elevated circulating leukemia inhibitory factor in patients with extensive burns. J Burn Care Res. 2006 Mar-Apr; 27(2):221-5. Akita S, Akino K, Ren SG, Melmed S, Imaizumi T, Hirano A. PMID: 16566572.
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    192. Supplemental growth hormone in healthy adults: the endocrinologist's responsibility. Nat Clin Pract Endocrinol Metab. 2006 Mar; 2(3):119. Melmed S. PMID: 16932266.
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    193. Cyclin-dependent kinase inhibitor gene polymorphisms in pituitary gigantism. Endocrine. 2006 Feb; 29(1):119-20. Yu R, Bonert V, Cruz-Soto M, Melmed S. PMID: 16622299.
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    194. [Pituitary tumorigenesis]. Arq Bras Endocrinol Metabol. 2005 Oct; 49(5):615-25. Bronstein MD, Melmed S. PMID: 16444345.
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    195. The neuroprotective WldS gene regulates expression of PTTG1 and erythroid differentiation regulator 1-like gene in mice and human cells. Hum Mol Genet. 2006 Feb 15; 15(4):625-35. Gillingwater TH, Wishart TM, Chen PE, Haley JE, Robertson K, MacDonald SH, Middleton S, Wawrowski K, Shipston MJ, Melmed S, Wyllie DJ, Skehel PA, Coleman MP, Ribchester RR. PMID: 16403805.
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    196. Implication of pituitary tropic status on tumor development. Front Horm Res. 2006; 35:1-8. Donangelo I, Melmed S. PMID: 16809918.
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    197. Prolactin receptor signaling mediates the osmotic response of embryonic zebrafish lactotrophs. Mol Endocrinol. 2006 Apr; 20(4):871-80. Liu NA, Liu Q, Wawrowsky K, Yang Z, Lin S, Melmed S. PMID: 16339273.
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    198. Consensus statement: medical management of acromegaly. Eur J Endocrinol. 2005 Dec; 153(6):737-40. Melmed S, Casanueva F, Cavagnini F, Chanson P, Frohman LA, Gaillard R, Ghigo E, Ho K, Jaquet P, Kleinberg D, Lamberts S, Laws E, Lombardi G, Sheppard MC, Thorner M, Vance ML, Wass JA, Giustina A. PMID: 16322377.
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    199. 2004 World Health Organization classification of pituitary tumors: what is new? Acta Neuropathol. 2006 Jan; 111(1):78-9. Melmed S. PMID: 16328519.
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    200. Treatment of acromegaly: future. Endocrine. 2005 Oct; 28(1):123-8. Donangelo I, Melmed S. PMID: 16311419.
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    201. A novel molecular marker of pituitary tumor transforming gene involves in a rat liver regeneration. J Surg Res. 2005 Nov; 129(1):142-6. Akino K, Akita S, Mizuguchi T, Takumi I, Yu R, Wang XY, Rozga J, Demetriou AA, Melmed S, Ohtsuru A, Yamashita S. PMID: 15936773.
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    202. Pituitary hypoplasia in Pttg-/- mice is protective for Rb+/- pituitary tumorigenesis. Mol Endocrinol. 2005 Sep; 19(9):2371-9. Chesnokova V, Kovacs K, Castro AV, Zonis S, Melmed S. PMID: 15919720; PMCID: PMC1201444.
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    203. Somatostatin receptor type 5 modulates somatostatin receptor type 2 regulation of adrenocorticotropin secretion. J Biol Chem. 2005 Jun 24; 280(25):24011-21. Ben-Shlomo A, Wawrowsky KA, Proekt I, Wolkenfeld NM, Ren SG, Taylor J, Culler MD, Melmed S. PMID: 15857828.
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    204. A critical analysis of pituitary tumor shrinkage during primary medical therapy in acromegaly. J Clin Endocrinol Metab. 2005 Jul; 90(7):4405-10. Melmed S, Sternberg R, Cook D, Klibanski A, Chanson P, Bonert V, Vance ML, Rhew D, Kleinberg D, Barkan A. PMID: 15827109.
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    205. Early multipotential pituitary focal hyperplasia in the alpha-subunit of glycoprotein hormone-driven pituitary tumor-transforming gene transgenic mice. Mol Endocrinol. 2005 May; 19(5):1383-91. Abbud RA, Takumi I, Barker EM, Ren SG, Chen DY, Wawrowsky K, Melmed S. PMID: 15677710.
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    206. Pathophysiology of pituitary adenomas. J Endocrinol Invest. 2005; 28(11 Suppl International):100-5. Donangelo I, Melmed S. PMID: 16625857.
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    207. PTTG's C-terminal PXXP motifs modulate critical cellular processes in vitro. J Mol Endocrinol. 2004 Dec; 33(3):663-77. Boelaert K, Yu R, Tannahill LA, Stratford AL, Khanim FL, Eggo MC, Moore JS, Young LS, Gittoes NJ, Franklyn JA, Melmed S, McCabe CJ. PMID: 15591026.
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    208. Central and peripheral actions of somatostatin on the growth hormone-IGF-I axis. J Clin Invest. 2004 Aug; 114(3):349-56. Murray RD, Kim K, Ren SG, Chelly M, Umehara Y, Melmed S. PMID: 15286801; PMCID: PMC484973.
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    209. Body mass index determines evoked growth hormone (GH) responsiveness in normal healthy male subjects: diagnostic caveat for adult GH deficiency. J Clin Endocrinol Metab. 2004 Jul; 89(7):3397-401. Bonert VS, Elashoff JD, Barnett P, Melmed S. PMID: 15240621.
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    210. The novel somatostatin ligand (SOM230) regulates human and rat anterior pituitary hormone secretion. J Clin Endocrinol Metab. 2004 Jun; 89(6):3027-32. Murray RD, Kim K, Ren SG, Lewis I, Weckbecker G, Bruns C, Melmed S. PMID: 15181094.
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    211. Molecular targets in pituitary tumours. Nat Rev Cancer. 2004 Apr; 4(4):285-95. Heaney AP, Melmed S. PMID: 15057288.
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    212. Pituitary tumor transforming gene: an update. Front Horm Res. 2004; 32:175-85. Yu R, Melmed S. PMID: 15281346.
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    213. Mechanisms for pituitary tumorigenesis: the plastic pituitary. J Clin Invest. 2003 Dec; 112(11):1603-18. Melmed S. PMID: 14660734; PMCID: PMC281651.
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    214. Suppression of rat and human growth hormone and prolactin secretion by a novel somatostatin/dopaminergic chimeric ligand. J Clin Endocrinol Metab. 2003 Nov; 88(11):5414-21. Ren SG, Kim S, Taylor J, Dong J, Moreau JP, Culler MD, Melmed S. PMID: 14602782.
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    215. Cell-specific pituitary gene expression profiles after treatment with leukemia inhibitory factor reveal novel modulators for proopiomelanocortin expression. Endocrinology. 2004 Feb; 145(2):867-80. Abbud RA, Kelleher R, Melmed S. PMID: 14576184.
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    216. Optimizing control of acromegaly: integrating a growth hormone receptor antagonist into the treatment algorithm. J Clin Endocrinol Metab. 2003 Oct; 88(10):4759-67. Clemmons DR, Chihara K, Freda PU, Ho KK, Klibanski A, Melmed S, Shalet SM, Strasburger CJ, Trainer PJ, Thorner MO. PMID: 14557452.
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    217. Angiogenesis in endocrine tumors. Endocr Rev. 2003 Oct; 24(5):600-32. Turner HE, Harris AL, Melmed S, Wass JA. PMID: 14570746.
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    218. Functional association of somatostatin receptor subtypes 2 and 5 in inhibiting human growth hormone secretion. J Clin Endocrinol Metab. 2003 Sep; 88(9):4239-45. Ren SG, Taylor J, Dong J, Yu R, Culler MD, Melmed S. PMID: 12970293.
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    219. The cell adhesion molecules N-cadherin and neural cell adhesion molecule regulate human growth hormone: a novel mechanism for regulating pituitary hormone secretion. J Clin Endocrinol Metab. 2003 Aug; 88(8):3724-30. Rubinek T, Yu R, Hadani M, Barkai G, Nass D, Melmed S, Shimon I. PMID: 12915661.
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    220. Overexpressed pituitary tumor-transforming gene causes aneuploidy in live human cells. Endocrinology. 2003 Nov; 144(11):4991-8. Yu R, Lu W, Chen J, McCabe CJ, Melmed S. PMID: 12960092.
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    221. PPAR-gamma receptor ligands: novel therapy for pituitary adenomas. J Clin Invest. 2003 May; 111(9):1381-8. Heaney AP, Fernando M, Melmed S. PMID: 12727930; PMCID: PMC154441.
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    222. Acromegaly consensus: the next steps. J Clin Endocrinol Metab. 2003 Apr; 88(4):1913-4. Giustina A, Melmed S. PMID: 12679495.
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    223. Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic beta cell proliferation and diabetes. Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6):3428-32. Wang Z, Moro E, Kovacs K, Yu R, Melmed S. PMID: 12626748; PMCID: PMC152309.
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    224. Clinical review 154: The role of pharmacotherapy in perioperative management of patients with acromegaly. J Clin Endocrinol Metab. 2003 Mar; 88(3):963-8. Ben-Shlomo A, Melmed S. PMID: 12629068.
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    225. Pituitary corticotroph ontogeny and regulation in transgenic zebrafish. Mol Endocrinol. 2003 May; 17(5):959-66. Liu NA, Huang H, Yang Z, Herzog W, Hammerschmidt M, Lin S, Melmed S. PMID: 12576489.
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    226. Leukemia inhibitory factor regulates prolactin secretion in prolactinoma and lactotroph cells. J Clin Endocrinol Metab. 2003 Feb; 88(2):858-63. Ben-Shlomo A, Miklovsky I, Ren SG, Yong WH, Heaney AP, Culler MD, Melmed S. PMID: 12574225.
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    227. Human pituitary tumor-transforming gene (PTTG1) motif suppresses prolactin expression. Mol Endocrinol. 2003 Apr; 17(4):600-9. Horwitz GA, Miklovsky I, Heaney AP, Ren SG, Melmed S. PMID: 12554778.
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    228. Expression and function of pituitary tumour transforming gene for T-lymphocyte activation. Br J Haematol. 2002 Dec; 119(4):1070-4. Stoika R, Melmed S. PMID: 12472590.
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    229. Guidelines for acromegaly management. J Clin Endocrinol Metab. 2002 Sep; 87(9):4054-8. Melmed S, Casanueva FF, Cavagnini F, Chanson P, Frohman L, Grossman A, Ho K, Kleinberg D, Lamberts S, Laws E, Lombardi G, Vance ML, Werder KV, Wass J, Giustina A, Acromegaly Treatment Consensus Workshop Participants. PMID: 12213843.
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    230. Opposing effects of pituitary leukemia inhibitory factor and SOCS-3 on the ACTH axis response to inflammation. Am J Physiol Endocrinol Metab. 2002 May; 282(5):E1110-8. Chesnokova V, Kariagina A, Melmed S. PMID: 11934677.
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    231. Current status and future opportunities for controlling acromegaly. Pituitary. 2002; 5(3):185-96. Melmed S, Vance ML, Barkan AL, Bengtsson BA, Kleinberg D, Klibanski A, Trainer PJ. PMID: 12812311.
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    232. Functional role of estrogen in pituitary tumor pathogenesis. J Clin Invest. 2002 Jan; 109(2):277-83. Heaney AP, Fernando M, Melmed S. PMID: 11805140; PMCID: PMC150842.
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    233. Series introduction. The immuno-neuroendocrine interface. J Clin Invest. 2001 Dec; 108(11):1563-6. Melmed S. PMID: 11733548; PMCID: PMC201000.
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    234. Long-term treatment of acromegaly with pegvisomant, a growth hormone receptor antagonist. Lancet. 2001 Nov 24; 358(9295):1754-9. van der Lely AJ, Hutson RK, Trainer PJ, Besser GM, Barkan AL, Katznelson L, Klibanski A, Herman-Bonert V, Melmed S, Vance ML, Freda PU, Stewart PM, Friend KE, Clemmons DR, Johannsson G, Stavrou S, Cook DM, Phillips LS, Strasburger CJ, Hackett S, Zib KA, Davis RJ, Scarlett JA, Thorner MO. PMID: 11734231.
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    235. The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription. Biol Chem. 2001 Oct; 382(10):1447-53. Bode JG, Ludwig S, Freitas CA, Schaper F, Ruhl M, Melmed S, Heinrich PC, Häussinger D. PMID: 11727828.
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    236. Acromegaly and cancer: not a problem? J Clin Endocrinol Metab. 2001 Jul; 86(7):2929-34. Melmed S. PMID: 11443145.
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    237. Oncogene activation in pituitary tumors. Brain Pathol. 2001 Jul; 11(3):328-41. Yu R, Melmed S. PMID: 11414475; PMCID: PMC8098594.
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    238. Human pituitary tumor-transforming gene induces angiogenesis. J Clin Endocrinol Metab. 2001 Feb; 86(2):867-74. Ishikawa H, Heaney AP, Yu R, Horwitz GA, Melmed S. PMID: 11158059.
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    239. Direct regulation of pituitary proopiomelanocortin by STAT3 provides a novel mechanism for immuno-neuroendocrine interfacing. J Clin Invest. 2000 Dec; 106(11):1417-25. Bousquet C, Zatelli MC, Melmed S. PMID: 11104795; PMCID: PMC381469.
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    240. Pituitary tumor transforming gene causes aneuploidy and p53-dependent and p53-independent apoptosis. J Biol Chem. 2000 Nov 24; 275(47):36502-5. Yu R, Heaney AP, Lu W, Chen J, Melmed S. PMID: 11013229.
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    241. Leukemia inhibitory factor mediates the hypothalamic pituitary adrenal axis response to inflammation. Endocrinology. 2000 Nov; 141(11):4032-40. Chesnokova V, Melmed S. PMID: 11089533.
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    242. Long-acting peptidomimergic control of gigantism caused by pituitary acidophilic stem cell adenoma. J Clin Endocrinol Metab. 2000 Sep; 85(9):3409-16. Maheshwari HG, Prezant TR, Herman-Bonert V, Shahinian H, Kovacs K, Melmed S. PMID: 10999842.
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    243. Growth hormone receptor antagonist therapy in acromegalic patients resistant to somatostatin analogs. J Clin Endocrinol Metab. 2000 Aug; 85(8):2958-61. Herman-Bonert VS, Zib K, Scarlett JA, Melmed S. PMID: 10946911.
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    244. Pituitary tumor transforming gene (PTTG) regulates placental JEG-3 cell division and survival: evidence from live cell imaging. Mol Endocrinol. 2000 Aug; 14(8):1137-46. Yu R, Ren SG, Horwitz GA, Wang Z, Melmed S. PMID: 10935539.
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    245. Leukemia-inhibitory factor-neuroimmune modulator of endocrine function. Endocr Rev. 2000 Jun; 21(3):313-45. Auernhammer CJ, Melmed S. PMID: 10857556.
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    246. Expression of leukemia inhibitory factor in human pituitary adenomas: a morphologic and immunocytochemical study. Pituitary. 2000 May; 2(4):245-51. Kontogeorgos G, Patralexis H, Tran A, Kovacs K, Melmed S. PMID: 11081145.
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    247. Pituitary tumor transforming gene (PTTG) transforming and transactivation activity. J Biol Chem. 2000 Mar 17; 275(11):7459-61. Wang Z, Melmed S. PMID: 10713046.
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    248. New pituitary oncogenes. Endocr Relat Cancer. 2000 Mar; 7(1):3-15. Heaney AP, Melmed S. PMID: 10808192.
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    249. Expression of pituitary-tumour transforming gene in colorectal tumours. Lancet. 2000 Feb 26; 355(9205):716-9. Heaney AP, Singson R, McCabe CJ, Nelson V, Nakashima M, Melmed S. PMID: 10703804.
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    250. Characterization of the murine pituitary tumor transforming gene (PTTG) and its promoter. Endocrinology. 2000 Feb; 141(2):763-71. Wang Z, Melmed S. PMID: 10650958.
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    251. Criteria for cure of acromegaly: a consensus statement. J Clin Endocrinol Metab. 2000 Feb; 85(2):526-9. Giustina A, Barkan A, Casanueva FF, Cavagnini F, Frohman L, Ho K, Veldhuis J, Wass J, Von Werder K, Melmed S. PMID: 10690849.
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    252. Octreotide Effect on Growth Hormone and Somatostatin Subtype 2 Receptor mRNAs of the Human Pituitary Somatotroph Adenomas. Endocr Pathol. 2000; 11(1):41-48. Stefaneanu L, Kovacs K, Thapar K, Horvath E, Melmed S, Greenman Y. PMID: 12114656.
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    253. SOCS proteins: modulators of neuroimmunoendocrine functions. Impact on corticotroph LIF signaling. Ann N Y Acad Sci. 2000; 917:658-64. Auernhammer CJ, Bousquet C, Chesnokova V, Melmed S. PMID: 11268394.
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    254. Pituitary tumor registry: a novel clinical resource. J Clin Endocrinol Metab. 2000 Jan; 85(1):168-74. Drange MR, Fram NR, Herman-Bonert V, Melmed S. PMID: 10634382.
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    255. Leukaemia inhibitory factor enhances tissue factor expression in human monocyte-derived macrophages: a gp130-mediated mechanism. Br J Haematol. 1999 Dec; 107(4):747-55. Meisel SR, Shimon I, Edgington TS, Melmed S, Cercek B, Shah PK. PMID: 10606879.
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    256. Early involvement of estrogen-induced pituitary tumor transforming gene and fibroblast growth factor expression in prolactinoma pathogenesis. Nat Med. 1999 Nov; 5(11):1317-21. Heaney AP, Horwitz GA, Wang Z, Singson R, Melmed S. PMID: 10546001.
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    257. Inhibitory roles for SHP-1 and SOCS-3 following pituitary proopiomelanocortin induction by leukemia inhibitory factor. J Clin Invest. 1999 Nov; 104(9):1277-85. Bousquet C, Susini C, Melmed S. PMID: 10545526; PMCID: PMC409825.
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    258. Pituitary tumour transforming gene: a novel factor in pituitary tumour formation. Baillieres Best Pract Res Clin Endocrinol Metab. 1999 Oct; 13(3):367-80. Heaney AP, Melmed S. PMID: 10909429.
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    259. Insulin-like growth factor I--a prototypic peripheral-paracrine hormone? Endocrinology. 1999 Sep; 140(9):3879-80. Melmed S. PMID: 10465255.
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    260. Confusion in clinical laboratory GH and IGF-I reports. Pituitary. 1999 Aug; 2(2):171-2. Melmed S. PMID: 11081168.
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    261. In vivo and in vitro regulation of thyroid leukemia inhibitory factor (LIF): marker of hypothyroidism. J Clin Endocrinol Metab. 1999 Aug; 84(8):2883-7. Ren SG, Seliktar J, Li X, Hershman JM, Braunstein GD, Melmed S. PMID: 10443695.
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    262. Autoregulation of pituitary corticotroph SOCS-3 expression: characterization of the murine SOCS-3 promoter. Proc Natl Acad Sci U S A. 1999 Jun 08; 96(12):6964-9. Auernhammer CJ, Bousquet C, Melmed S. PMID: 10359822; PMCID: PMC22025.
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    263. Expression of leukemia inhibitory factor in craniopharyngioma. Endocr Pathol. 1999 Jun; 10(2):103-8. Tran A, Kovacs K, Stefaneanu L, Kontogeorgos G, Scheithauer BW, Melmed S. PMID: 27519214.
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    264. Molecular pathogenesis of acromegaly. Pituitary. 1999 Jun; 2(1):43-50. Drange MR, Melmed S. PMID: 11081171.
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    265. Critical role for STAT3 in murine pituitary adrenocorticotropin hormone leukemia inhibitory factor signaling. J Biol Chem. 1999 Apr 16; 274(16):10723-30. Bousquet C, Melmed S. PMID: 10196143.
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    266. Interleukin-11 stimulates proopiomelanocortin gene expression and adrenocorticotropin secretion in corticotroph cells: evidence for a redundant cytokine network in the hypothalamo-pituitary-adrenal axis. Endocrinology. 1999 Apr; 140(4):1559-66. Auernhammer CJ, Melmed S. PMID: 10098488.
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    267. Pathogenesis of pituitary tumors. Endocrinol Metab Clin North Am. 1999 Mar; 28(1):1-12, v. Melmed S. PMID: 10207683.
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    268. An intronless homolog of human proto-oncogene hPTTG is expressed in pituitary tumors: evidence for hPTTG family. J Clin Endocrinol Metab. 1999 Mar; 84(3):1149-52. Prezant TR, Kadioglu P, Melmed S. PMID: 10084610.
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    269. Stimulatory effect of leukemia inhibitory factor on ACTH secretion of dispersed rat pituitary cells. Endocr Res. 1999 Feb; 25(1):11-9. Kim DS, Melmed S. PMID: 10098589.
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    270. Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas. J Clin Endocrinol Metab. 1999 Feb; 84(2):761-7. Zhang X, Horwitz GA, Heaney AP, Nakashima M, Prezant TR, Bronstein MD, Melmed S. PMID: 10022450.
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    271. Structure, expression, and function of human pituitary tumor-transforming gene (PTTG). Mol Endocrinol. 1999 Jan; 13(1):156-66. Zhang X, Horwitz GA, Prezant TR, Valentini A, Nakashima M, Bronstein MD, Melmed S. PMID: 9892021.
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    272. Loss of heterozygosity on chromosome 11q13 in two families with acromegaly/gigantism is independent of mutations of the multiple endocrine neoplasia type I gene. J Clin Endocrinol Metab. 1999 Jan; 84(1):249-56. Gadelha MR, Prezant TR, Une KN, Glick RP, Moskal SF, Vaisman M, Melmed S, Kineman RD, Frohman LA. PMID: 9920092.
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    273. Intact leptin receptor is selectively expressed in human fetal pituitary and pituitary adenomas and signals human fetal pituitary growth hormone secretion. J Clin Endocrinol Metab. 1998 Nov; 83(11):4059-64. Shimon I, Yan X, Magoffin DA, Friedman TC, Melmed S. PMID: 9814492.
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    274. Pituitary-directed leukemia inhibitory factor transgene causes Cushing's syndrome: neuro-immune-endocrine modulation of pituitary development. Mol Endocrinol. 1998 Nov; 12(11):1708-20. Yano H, Readhead C, Nakashima M, Ren SG, Melmed S. PMID: 9817597.
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    275. Functional map of a placenta-specific enhancer of the human leukemia inhibitory factor receptor gene. J Biol Chem. 1998 Oct 02; 273(40):26069-77. Wang Z, Melmed S. PMID: 9748286.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    276. Tight control of growth hormone: an attainable outcome for acromegaly treatment. J Clin Endocrinol Metab. 1998 Oct; 83(10):3409-10. Melmed S. PMID: 9768639.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    277. Management of pituitary tumors. Ann Intern Med. 1998 Sep 15; 129(6):472-83. Shimon I, Melmed S. PMID: 9735086.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    278. Long-acting lanreotide induces clinical and biochemical remission of acromegaly caused by disseminated growth hormone-releasing hormone-secreting carcinoid. J Clin Endocrinol Metab. 1998 Sep; 83(9):3104-9. Drange MR, Melmed S. PMID: 9745411.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    279. Octreotide as primary therapy for acromegaly. J Clin Endocrinol Metab. 1998 Sep; 83(9):3034-40. Newman CB, Melmed S, George A, Torigian D, Duhaney M, Snyder P, Young W, Klibanski A, Molitch ME, Gagel R, Sheeler L, Cook D, Malarkey W, Jackson I, Vance ML, Barkan A, Frohman L, Kleinberg DL. PMID: 9745397.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCTClinical Trials
    280. Current treatment guidelines for acromegaly. J Clin Endocrinol Metab. 1998 Aug; 83(8):2646-52. Melmed S, Jackson I, Kleinberg D, Klibanski A. PMID: 9709926.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    281. Pituitary corticotroph SOCS-3: novel intracellular regulation of leukemia-inhibitory factor-mediated proopiomelanocortin gene expression and adrenocorticotropin secretion. Mol Endocrinol. 1998 Jul; 12(7):954-61. Auernhammer CJ, Chesnokova V, Bousquet C, Melmed S. PMID: 9658400.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    282. gp130-Related Cytokines and Their Receptors in the Pituitary. Trends Endocrinol Metab. 1998 May-Jun; 9(4):155-61. Melmed S. PMID: 18406260.
      View in: PubMed   Mentions:    Fields:    
    283. Leukemia inhibitory factor regulates proopiomelanocortin transcription. Ann N Y Acad Sci. 1998 May 01; 840:162-73. Ray DW, Ren SG, Melmed S. PMID: 9629248.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    284. Leukemia inhibitory factor modulates interleukin-1beta-induced activation of the hypothalamo-pituitary-adrenal axis. Endocrinology. 1998 May; 139(5):2201-8. Auernhammer CJ, Chesnokova V, Melmed S. PMID: 9564823.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    285. Murine leukemia inhibitory factor gene disruption attenuates the hypothalamo-pituitary-adrenal axis stress response. Endocrinology. 1998 May; 139(5):2209-16. Chesnokova V, Auernhammer CJ, Melmed S. PMID: 9564824.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    286. Mutation and expression analysis of the cyclin-dependent kinase inhibitor gene p27/Kip1 in pituitary tumors. J Endocrinol. 1998 May; 157(2):337-41. Takeuchi S, Koeffler HP, Hinton DR, Miyoshi I, Melmed S, Shimon I. PMID: 9659297.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    287. Measurement of leukemia inhibitory factor in biological fluids by radioimmunoassay. J Clin Endocrinol Metab. 1998 Apr; 83(4):1275-83. Ren SG, Seliktar J, Li X, Braunstein GD, Melmed S. PMID: 9543156.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    288. Molecular characterization of the men1 tumor suppressor gene in sporadic pituitary tumors. J Clin Endocrinol Metab. 1998 Apr; 83(4):1388-91. Prezant TR, Levine J, Melmed S. PMID: 9543172.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCTClinical Trials
    289. Pregnancy in acromegaly: successful therapeutic outcome. J Clin Endocrinol Metab. 1998 Mar; 83(3):727-31. Herman-Bonert V, Seliverstov M, Melmed S. PMID: 9506716.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    290. Prolactinomas express human heparin-binding secretory transforming gene (hst) protein product: marker of tumour invasiveness. Clin Endocrinol (Oxf). 1998 Jan; 48(1):23-9. Shimon I, Hinton DR, Weiss MH, Melmed S. PMID: 9509064.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    291. Human fetal pituitary expresses functional growth hormone-releasing peptide receptors. J Clin Endocrinol Metab. 1998 Jan; 83(1):174-8. Shimon I, Yan X, Melmed S. PMID: 9435437.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    292. Diagnosis and treatment of pituitary disease. Psychother Psychosom. 1998; 67(3):119-24. Shimon I, Melmed S. PMID: 9667058.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    293. gp130-Related cytokines and their receptors in the pituitary. Trends Endocrinol Metab. 1997 Dec; 8(10):391-7. Melmed S. PMID: 18406828.
      View in: PubMed   Mentions: 2     Fields:    
    294. Leukemia inhibitory factor (LIF) modulates pro-opiomelanocortin (POMC) gene regulation in stably transfected AtT-20 cells overexpressing LIF. Endocrine. 1997 Dec; 7(3):325-30. Li QL, Yano H, Ren SG, Li X, Friedman TC, Melmed S. PMID: 9657069.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    295. Somatostatin receptor (SSTR) subtype-selective analogues differentially suppress in vitro growth hormone and prolactin in human pituitary adenomas. Novel potential therapy for functional pituitary tumors. J Clin Invest. 1997 Nov 01; 100(9):2386-92. Shimon I, Yan X, Taylor JE, Weiss MH, Culler MD, Melmed S. PMID: 9410919; PMCID: PMC508437.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    296. Identification of an upstream enhancer within a functional promoter of the human leukemia inhibitory factor receptor gene and its alternative promoter usage. J Biol Chem. 1997 Oct 31; 272(44):27957-65. Wang Z, Melmed S. PMID: 9346946.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    297. Structure and function of somatostatin receptors in growth hormone control. J Endocrinol. 1997 Oct; 155 Suppl 1:S3-6; discussion S7-8. Shimon I, Melmed S. PMID: 9389989.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    298. Cytokine-dependent gp130 receptor subunit regulates human fetal pituitary adrenocorticotropin hormone and growth hormone secretion. J Clin Invest. 1997 Jul 15; 100(2):357-63. Shimon I, Yan X, Ray DW, Melmed S. PMID: 9218512; PMCID: PMC508198.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    299. Decidual leukemia inhibitory factor production and action on human chorionic gonadotropin secretion at different stages of gestation in vitro. Early Pregnancy. 1997 Jun; 3(2):102-8. Ren SG, Melmed S, Braunstein GD. PMID: 9429850.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    300. Genetic basis of endocrine disease: pituitary tumor pathogenesis. J Clin Endocrinol Metab. 1997 Jun; 82(6):1675-81. Shimon I, Melmed S. PMID: 9177361.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    301. Pituitary-directed leukemia inhibitory factor transgene forms Rathke's cleft cysts and impairs adult pituitary function. A model for human pituitary Rathke's cysts. J Clin Invest. 1997 May 15; 99(10):2462-9. Akita S, Readhead C, Stefaneanu L, Fine J, Tampanaru-Sarmesiu A, Kovacs K, Melmed S. PMID: 9153290; PMCID: PMC508087.
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    302. A common pro-opiomelanocortin-binding element mediates leukemia inhibitory factor and corticotropin-releasing hormone transcriptional synergy. J Biol Chem. 1997 Apr 18; 272(16):10551-7. Bousquet C, Ray DW, Melmed S. PMID: 9099700.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    303. Isolation and characterization of a pituitary tumor-transforming gene (PTTG). Mol Endocrinol. 1997 Apr; 11(4):433-41. Pei L, Melmed S. PMID: 9092795.
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    304. Pituitary cytokine and growth factor expression and action. Endocr Rev. 1997 Apr; 18(2):206-28. Ray D, Melmed S. PMID: 9101137.
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    305. Somatostatin receptor subtype specificity in human fetal pituitary cultures. Differential role of SSTR2 and SSTR5 for growth hormone, thyroid-stimulating hormone, and prolactin regulation. J Clin Invest. 1997 Feb 15; 99(4):789-98. Shimon I, Taylor JE, Dong JZ, Bitonte RA, Kim S, Morgan B, Coy DH, Culler MD, Melmed S. PMID: 9045884; PMCID: PMC507864.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    306. Growth hormone- and growth-hormone-releasing hormone-producing tumors. Cancer Treat Res. 1997; 89:1-24. Shimon I, Melmed S. PMID: 9204185.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    307. Short-term recombinant human growth hormone treatment increases growth rate in achondroplasia. J Clin Endocrinol Metab. 1996 Nov; 81(11):4033-7. Shohat M, Tick D, Barakat S, Bu X, Melmed S, Rimoin DL. PMID: 8923856.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    308. Leukemia inhibitory factor (LIF) induces acute adrenocorticotrophic hormone (ACTH) secretion in fetal rhesus macaque primates: a novel dynamic test of pituitary function. J Clin Endocrinol Metab. 1996 Nov; 81(11):4170-8. Akita S, Conn PM, Melmed S. PMID: 8923879.
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    309. Leukemia inhibitory factor induces differentiation of pituitary corticotroph function: an immuno-neuroendocrine phenotypic switch. Proc Natl Acad Sci U S A. 1996 Oct 29; 93(22):12502-6. Stefana B, Ray DW, Melmed S. PMID: 8901611; PMCID: PMC38021.
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    310. Molecular pathophysiology of acromegaly. Acta Paediatr Suppl. 1996 Oct; 417:45-8. Melmed S. PMID: 9055908.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    311. Acromegaly. Metabolism. 1996 Aug; 45(8 Suppl 1):51-2. Melmed S. PMID: 8769381.
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    312. Hypothalamic and pituitary leukemia inhibitory factor gene expression in vivo: a novel endotoxin-inducible neuro-endocrine interface. Endocrinology. 1996 Jul; 137(7):2947-53. Wang Z, Ren SG, Melmed S. PMID: 8770918.
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    313. Disrupted murine leukemia inhibitory factor (LIF) gene attenuates adrenocorticotropic hormone (ACTH) secretion. Endocrinology. 1996 Jul; 137(7):3140-3. Akita S, Malkin J, Melmed S. PMID: 8770940.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    314. Unwanted effects of growth hormone excess in the adult. J Pediatr Endocrinol Metab. 1996 Jun; 9 Suppl 3:369-74. Melmed S. PMID: 8887183.
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    315. Leukemia inhibitory factor (LIF) stimulates proopiomelanocortin (POMC) expression in a corticotroph cell line. Role of STAT pathway. J Clin Invest. 1996 Apr 15; 97(8):1852-9. Ray DW, Ren SG, Melmed S. PMID: 8621768; PMCID: PMC507253.
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    316. Remission of acromegaly caused by pituitary carcinoma after surgical excision of growth hormone-secreting metastasis detected by 111-indium pentetreotide scan. J Clin Endocrinol Metab. 1996 Apr; 81(4):1628-33. Greenman Y, Woolf P, Coniglio J, O'Mara R, Pei L, Said JW, Melmed S. PMID: 8636379.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    317. Structure of the thyrotrophin-releasing hormone receptor in human pituitary adenomas. Clin Endocrinol (Oxf). 1996 Mar; 44(3):341-7. Faccenda E, Melmed S, Bevan JS, Eidne KA. PMID: 8729534.
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    318. Diagnosis and management of nonfunctioning pituitary tumors. Annu Rev Med. 1996; 47:95-106. Greenman Y, Melmed S. PMID: 8712806.
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    319. IGF-I receptor signalling: lessons from the somatotroph. Recent Prog Horm Res. 1996; 51:189-215; discussion 215-6. Melmed S, Yamashita S, Yamasaki H, Fagin J, Namba H, Yamamoto H, Weber M, Morita S, Webster J, Prager D. PMID: 8701079.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    320. Heparin-binding secretory transforming gene (hst) facilitates rat lactotrope cell tumorigenesis and induces prolactin gene transcription. J Clin Invest. 1996 Jan 01; 97(1):187-95. Shimon I, Hüttner A, Said J, Spirina OM, Melmed S. PMID: 8550832; PMCID: PMC507078.
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    321. Clinical review 75: Recent advances in pathogenesis, diagnosis, and management of acromegaly. J Clin Endocrinol Metab. 1995 Dec; 80(12):3395-402. Melmed S, Ho K, Klibanski A, Reichlin S, Thorner M. PMID: 8530571.
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    322. Alterations of the p16 (MTS1) gene in testicular, ovarian, and endometrial malignancies. J Urol. 1995 Nov; 154(5):1954-7. Hatta Y, Hirama T, Takeuchi S, Lee E, Pham E, Miller CW, Strohmeyer T, Wilczynski SP, Melmed S, Koeffler HP. PMID: 7563391.
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    323. Safety and efficacy of long-term octreotide therapy of acromegaly: results of a multicenter trial in 103 patients--a clinical research center study. J Clin Endocrinol Metab. 1995 Sep; 80(9):2768-75. Newman CB, Melmed S, Snyder PJ, Young WF, Boyajy LD, Levy R, Stewart WN, Klibanski A, Molitch ME, Gagel RF. PMID: 7673422.
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    324. Characterization of the rat vasoactive intestinal polypeptide receptor gene 5' region. Biochem J. 1995 Jun 15; 308 ( Pt 3):719-23. Pei L, Melmed S. PMID: 8948424; PMCID: PMC1136784.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    325. Diagnostic controversy: the diagnosis of childhood growth hormone deficiency revisited. J Clin Endocrinol Metab. 1995 May; 80(5):1532-40. Rosenfeld RG, Albertsson-Wikland K, Cassorla F, Frasier SD, Hasegawa Y, Hintz RL, Lafranchi S, Lippe B, Loriaux L, Melmed S, et al. PMID: 7538145.
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    326. Purine-binding factor (nm23) gene expression in pituitary tumors: marker of adenoma invasiveness. J Clin Endocrinol Metab. 1995 May; 80(5):1733-8. Takino H, Herman V, Weiss M, Melmed S. PMID: 7745027.
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    327. Frequent loss of heterozygosity at the retinoblastoma susceptibility gene (RB) locus in aggressive pituitary tumors: evidence for a chromosome 13 tumor suppressor gene other than RB. Cancer Res. 1995 Apr 15; 55(8):1613-6. Pei L, Melmed S, Scheithauer B, Kovacs K, Benedict WF, Prager D. PMID: 7712461.
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    328. Human and murine pituitary expression of leukemia inhibitory factor. Novel intrapituitary regulation of adrenocorticotropin hormone synthesis and secretion. J Clin Invest. 1995 Mar; 95(3):1288-98. Akita S, Webster J, Ren SG, Takino H, Said J, Zand O, Melmed S. PMID: 7883977; PMCID: PMC441468.
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    329. The IGF-I receptor sub-membrane domain is intact in GH-secreting pituitary tumours. Clin Endocrinol (Oxf). 1995 Feb; 42(2):169-72. Greenman Y, Prager D, Melmed S. PMID: 7704960.
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    330. The neurofibromatosis gene in human pituitary adenomas. Endocr Pathol. 1994 Dec; 5(4):229-232. Pei L, Melmed S. PMID: 32138455.
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    331. Octreotide stimulates insulin-like growth factor binding protein-1: a novel mechanism of drug action on acromegaly. Semin Oncol. 1994 Oct; 21(5 Suppl 13):65-9. Melmed S. PMID: 7527593.
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    332. Expression of three somatostatin receptor subtypes in pituitary adenomas: evidence for preferential SSTR5 expression in the mammosomatotroph lineage. J Clin Endocrinol Metab. 1994 Sep; 79(3):724-9. Greenman Y, Melmed S. PMID: 7521350.
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    333. Role of the insulin-like growth factors in regulating neuroendocrine function. Neurobiol Aging. 1994 Jul-Aug; 15(4):569-72. Prager D, Yamasaki H, Weber MM, Melmed S. PMID: 7969742.
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    334. Insulin-like growth factor-1 activation of extracellular signal-related kinase-1 and -2 in growth hormone-secreting cells. Mol Endocrinol. 1994 May; 8(5):539-44. Webster J, Prager D, Melmed S. PMID: 8058064.
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    335. Human insulin-like growth factor I receptor internalization. Role of the juxtamembrane domain. J Biol Chem. 1994 Apr 22; 269(16):11934-7. Prager D, Li HL, Yamasaki H, Melmed S. PMID: 8163493.
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    336. H-ras mutations in human pituitary carcinoma metastases. J Clin Endocrinol Metab. 1994 Apr; 78(4):842-6. Pei L, Melmed S, Scheithauer B, Kovacs K, Prager D. PMID: 8157709.
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    337. Dominant negative inhibition of tumorigenesis in vivo by human insulin-like growth factor I receptor mutant. Proc Natl Acad Sci U S A. 1994 Mar 15; 91(6):2181-5. Prager D, Li HL, Asa S, Melmed S. PMID: 8134369; PMCID: PMC43334.
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    338. Pituitary neoplasia. Endocrinol Metab Clin North Am. 1994 Mar; 23(1):81-92. Melmed S. PMID: 7913031.
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    339. Heterogeneous expression of two somatostatin receptor subtypes in pituitary tumors. J Clin Endocrinol Metab. 1994 Feb; 78(2):398-403. Greenman Y, Melmed S. PMID: 8106629.
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    340. Hereditary endocrine tumors. Curr Ther Endocrinol Metab. 1994; 5:576-8. Melmed S. PMID: 7704796.
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    341. Rat pituitary GC cell insulin-like growth factor-I receptor regulation. Endocrinology. 1993 Sep; 133(3):1420-5. Yamamoto H, Prager D, Yamasaki H, Melmed S. PMID: 7689956.
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    342. Somatotroph insulin-like growth factor-I signaling. Ann N Y Acad Sci. 1993 Aug 27; 692:102-12. Prager D, Melmed S. PMID: 8215016.
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    343. Medical management of acromegaly--what and when? Acta Endocrinol (Copenh). 1993 Jul; 129 Suppl 1:13-7. Melmed S. PMID: 8372605.
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    344. Molecular screening of pituitary adenomas for gene mutations and rearrangements. J Clin Endocrinol Metab. 1993 Jul; 77(1):50-5. Herman V, Drazin NZ, Gonsky R, Melmed S. PMID: 8100831.
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    345. Recombinant growth hormone treatment of amyotrophic lateral sclerosis. Muscle Nerve. 1993 Jun; 16(6):624-33. Smith RA, Melmed S, Sherman B, Frane J, Munsat TL, Festoff BW. PMID: 8502260.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCTClinical Trials
    346. Biochemical assessment of bone formation and resorption in acromegaly. J Clin Endocrinol Metab. 1993 Jun; 76(6):1452-7. Ezzat S, Melmed S, Endres D, Eyre DR, Singer FR. PMID: 8501150.
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    347. Structure-function of the human insulin-like growth factor-I receptor: a discordance of somatotroph internalization and signaling. Mol Endocrinol. 1993 May; 7(5):681-5. Yamasaki H, Prager D, Melmed S. PMID: 8316251.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    348. Interaction between insulin and thyroid hormone in rat pituitary tumour cells: insulin attenuates tri-iodothyronine-induced growth hormone mRNA levels. J Endocrinol. 1993 Apr; 137(1):107-14. Prager D, Weber MM, Gebremedhin S, Melmed S. PMID: 8492068.
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    349. Insulin and insulin-like growth factor I receptors: are there functional distinctions? Endocrinology. 1993 Apr; 132(4):1419-20. Prager D, Melmed S. PMID: 8462444.
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    350. Recurrent acromegaly resulting from ectopic growth hormone gene expression by a metastatic pancreatic tumor. Cancer. 1993 Jan 01; 71(1):66-70. Ezzat S, Ezrin C, Yamashita S, Melmed S. PMID: 8416728.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    351. Octreotide stimulates insulin-like growth factor-binding protein-1: a potential pituitary-independent mechanism for drug action. J Clin Endocrinol Metab. 1992 Dec; 75(6):1459-63. Ezzat S, Ren SG, Braunstein GD, Melmed S. PMID: 1281485.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    352. Somatostatin analog induces insulin-like growth factor binding protein-1 (IGFBP-1) expression in human hepatoma cells. Endocrinology. 1992 Nov; 131(5):2479-81. Ren SG, Ezzat S, Melmed S, Braunstein GD. PMID: 1385103.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    353. Human insulin-like growth factor I receptor function in pituitary cells is suppressed by a dominant negative mutant. J Clin Invest. 1992 Nov; 90(5):2117-22. Prager D, Yamasaki H, Weber MM, Gebremedhin S, Melmed S. PMID: 1430235; PMCID: PMC443280.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    354. Rat somatotroph insulin-like growth factor-II (IGF-II) signaling: role of the IGF-I receptor. Endocrinology. 1992 Nov; 131(5):2147-53. Weber MM, Melmed S, Rosenbloom J, Yamasaki H, Prager D. PMID: 1425415.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    355. Human insulin-like growth factor I receptor 950tyrosine is required for somatotroph growth factor signal transduction. J Biol Chem. 1992 Oct 15; 267(29):20953-8. Yamasaki H, Prager D, Gebremedhin S, Melmed S. PMID: 1400411.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    356. Endocrine applications of the somatostatin analogue octreotide (Sandostatin). Metabolism. 1992 Sep; 41(9 Suppl 2):34-8. Ezzat S, Melmed S. PMID: 1518431.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    357. Symposium: basic somatostatin research. Metabolism. 1992 Sep; 41(9 Suppl 2):11-6. Sassolas G, Melmed S. PMID: 1355583.
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    358. Etiology of pituitary acromegaly. Endocrinol Metab Clin North Am. 1992 Sep; 21(3):539-51. Melmed S. PMID: 1521511.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    359. Transforming DNA sequences present in human prolactin-secreting pituitary tumors. Mol Endocrinol. 1991 Nov; 5(11):1687-95. Gonsky R, Herman V, Melmed S, Fagin J. PMID: 1779971.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    360. Extrapituitary acromegaly. Endocrinol Metab Clin North Am. 1991 Sep; 20(3):507-18. Melmed S. PMID: 1935918.
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    361. Octreotide stimulates insulin-like growth factor binding protein-1 (IGFBP-1) levels in acromegaly. J Clin Endocrinol Metab. 1991 Aug; 73(2):441-3. Ezzat S, Ren SG, Braunstein GD, Melmed S. PMID: 1713220.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    362. Insulin-like growth factor-I (IGF-I) attenuation of growth hormone is enhanced by overexpression of pituitary IGF-I receptors. Mol Endocrinol. 1991 Jul; 5(7):890-6. Yamasaki H, Prager D, Gebremedhin S, Melmed S. PMID: 1658632.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    363. Acromegaly: etiology, diagnosis and management. Compr Ther. 1991 Jul; 17(7):31-5. Ezzat S, Melmed S. PMID: 1742967.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    364. Clonality of endocrine tumors. Endocr Pathol. 1991 Jun; 2(2):61-63. Herman V, Melmed S. PMID: 32357607.
      View in: PubMed   Mentions:    Fields:    
    365. Colon polyps in acromegaly. Ann Intern Med. 1991 May 01; 114(9):754-5. Ezzat S, Strom C, Melmed S. PMID: 2012357.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    366. Deletion of 20p 11.23----pter with normal growth hormone-releasing hormone genes. Am J Med Genet. 1991 Apr 01; 39(1):56-63. Shohat M, Herman V, Melmed S, Neufeld N, Schreck R, Pulst S, Graham JM, Rimoin DL, Korenberg JR. PMID: 1867266.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    367. Binding and action of insulin-like growth factor I in pituitary tumor cells. Endocrinology. 1991 Feb; 128(2):857-62. Yamasaki H, Prager D, Gebremedhin S, Moise L, Melmed S. PMID: 1989866.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    368. Growth hormone regulation in primary fetal and neonatal rat pituitary cell cultures: the role of thyroid hormone. Endocrinology. 1991 Feb; 128(2):937-43. Ezzat S, Laks D, Oster J, Melmed S. PMID: 1989871.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    369. Clinical review 18: Are patients with acromegaly at increased risk for neoplasia? J Clin Endocrinol Metab. 1991 Feb; 72(2):245-9. Ezzat S, Melmed S. PMID: 1991795.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    370. Clonal origin of pituitary adenomas. J Clin Endocrinol Metab. 1990 Dec; 71(6):1427-33. Herman V, Fagin J, Gonsky R, Kovacs K, Melmed S. PMID: 1977759.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansCells
    371. Hypothalamic hormonal regulation of human growth hormone gene expression in somatotroph adenoma cell cultures. Endocr Pathol. 1990 Dec; 1(4):236-244. Herman V, Weiss M, Becker D, Melmed S. PMID: 32357615.
      View in: PubMed   Mentions:    Fields:    
    372. The role of growth factors in the pituitary. J Endocrinol Invest. 1990 Sep; 13(8):691-8. Ezzat S, Melmed S. PMID: 2273213.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    373. An insulin-induced DNA-binding protein for the human growth hormone gene. J Clin Invest. 1990 May; 85(5):1680-5. Prager D, Gebremedhin S, Melmed S. PMID: 2185279; PMCID: PMC296621.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    374. Acromegaly. N Engl J Med. 1990 Apr 05; 322(14):966-77. Melmed S. PMID: 2179724.
      View in: PubMed   Mentions: 102     Fields:    Translation:Humans
    375. In vivo regulation of hepatic insulin-like growth factor-1 messenger ribonucleic acids with thyroid hormone. Endocrinol Jpn. 1990 Apr; 37(2):205-11. Harakawa S, Yamashita S, Tobinaga T, Matsuo K, Hirayu H, Izumi M, Nagataki S, Melmed S. PMID: 2226339.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    376. Cardiac physiology, biochemistry and morphology in response to excess growth hormone in the rat. J Mol Cell Cardiol. 1990 Apr; 22(4):429-38. Rubin SA, Buttrick P, Malhotra A, Melmed S, Fishbein MC. PMID: 2143788.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    377. Thyroid hormone regulates rat pituitary insulin-like growth factor-I receptors. Endocrinology. 1990 Jan; 126(1):550-4. Matsuo K, Yamashita S, Niwa M, Kurihara M, Harakawa S, Izumi M, Nagataki S, Melmed S. PMID: 2152872.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    378. Pituitary insulin-like growth factor-I gene expression: regulation by triiodothyronine and growth hormone. Endocrinology. 1989 Nov; 125(5):2385-91. Fagin JA, Fernandez-Mejia C, Melmed S. PMID: 2791994.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    379. Reversible shrinkage of a growth hormone-secreting pituitary adenoma by a long-acting somatostatin analogue, octreotide. Arch Intern Med. 1989 Jun; 149(6):1443-5. Barakat S, Melmed S. PMID: 2730266.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    380. Retinoic acid selectively stimulates growth hormone secretion and messenger ribonucleic acid levels in rat pituitary cells. Endocrinology. 1989 May; 124(5):2052-6. Morita S, Fernandez-Mejia C, Melmed S. PMID: 2707148.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    381. Insulin-like growth factor-I action on growth hormone secretion and messenger ribonucleic acid levels: interaction with somatostatin. Endocrinology. 1989 Apr; 124(4):1794-9. Namba H, Morita S, Melmed S. PMID: 2564339.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    382. Identification of growth hormone at the myocardial cell surface. Am J Cardiovasc Pathol. 1989; 2(4):345-50. Siegel RJ, Fishbein MC, Said JW, Fealy M, Chai A, Rubin SA, Melmed S. PMID: 2675936.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    383. Insulin regulates expression of the human growth hormone gene in transfected cells. J Biol Chem. 1988 Nov 15; 263(32):16580-5. Prager D, Melmed S. PMID: 2903152.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    384. Medical management of acromegaly due to ectopic production of growth hormone-releasing hormone by a carcinoid tumor. J Clin Endocrinol Metab. 1988 Aug; 67(2):395-9. Melmed S, Ziel FH, Braunstein GD, Downs T, Frohman LA. PMID: 2899089.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    385. Insulin regulates prolactin secretion and messenger ribonucleic acid levels in pituitary cells. Endocrinology. 1988 Jun; 122(6):2946-52. Prager D, Yamashita S, Melmed S. PMID: 3286229.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    386. Regulation of pituitary insulin-like growth factor-I messenger ribonucleic acid levels in rats harboring somatomammotropic tumors: implications for growth hormone autoregulation. Endocrinology. 1988 May; 122(5):2204-10. Fagin JA, Brown A, Melmed S. PMID: 3359980.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    387. Insulin-like growth factor I action on rat anterior pituitary cells: effects of intracellular messengers on growth hormone secretion and messenger ribonucleic acid levels. Endocrinology. 1987 Dec; 121(6):2000-6. Morita S, Yamashita S, Melmed S. PMID: 3678137.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    388. Regulation of human growth hormone gene expression by insulin-like growth factor I in transfected cells. J Biol Chem. 1987 Sep 25; 262(27):13254-7. Yamashita S, Ong J, Melmed S. PMID: 3654610.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    389. Identification of human growth hormone messenger ribonucleic acid in pituitary adenoma cells by in situ hybridization. J Clin Endocrinol Metab. 1987 Sep; 65(3):575-80. Pixley S, Weiss M, Melmed S. PMID: 3624415.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    390. Ectopic pituitary and hypothalamic hormone syndromes. Endocrinol Metab Clin North Am. 1987 Sep; 16(3):805-21. Melmed S, Rushakoff RJ. PMID: 2891504.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    391. Insulin-like growth factor I gene expression in GH3 rat pituitary cells: messenger ribonucleic acid content, immunocytochemistry, and secretion. Endocrinology. 1987 May; 120(5):2037-43. Fagin JA, Pixley S, Slanina S, Ong J, Melmed S. PMID: 3552629.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    392. Cushing's syndrome due to ectopic proopiomelanocortin gene expression by islet cell carcinoma of the pancreas. Cancer. 1987 Feb 15; 59(4):772-8. Melmed S, Yamashita S, Kovacs K, Ong J, Rosenblatt S, Braunstein G. PMID: 3026608.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    393. Relative increase in insulin-like growth factor I messenger ribonucleic acid levels in compensatory renal hypertrophy. Endocrinology. 1987 Feb; 120(2):718-24. Fagin JA, Melmed S. PMID: 3803301.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    394. Insulinlike growth factor I regulation of growth hormone gene transcription in primary rat pituitary cells. J Clin Invest. 1987 Feb; 79(2):449-52. Yamashita S, Melmed S. PMID: 3805277; PMCID: PMC424098.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    395. Insulin-like growth factor I induces c-fos messenger ribonucleic acid in L6 rat skeletal muscle cells. Endocrinology. 1987 Jan; 120(1):353-7. Ong J, Yamashita S, Melmed S. PMID: 3536454.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    396. Expression of the myc cellular proto-oncogene in human thyroid tissue. J Clin Endocrinol Metab. 1986 Nov; 63(5):1170-3. Yamashita S, Ong J, Fagin JA, Melmed S. PMID: 3760117.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    397. Insulin regulation of rat growth hormone gene transcription. J Clin Invest. 1986 Oct; 78(4):1008-14. Yamashita S, Melmed S. PMID: 3531235; PMCID: PMC423746.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    398. Insulin-like growth factor I regulates growth hormone secretion and messenger ribonucleic acid levels in human pituitary tumor cells. J Clin Endocrinol Metab. 1986 Sep; 63(3):730-5. Yamashita S, Weiss M, Melmed S. PMID: 3016022.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    399. Pituitary tumors secreting growth hormone and prolactin. Ann Intern Med. 1986 Aug; 105(2):238-53. Melmed S, Braunstein GD, Chang RJ, Becker DP. PMID: 3524338.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    400. In vitro secretion of deoxycorticosterone by a benign Leydig cell tumor of the testis. J Urol. 1986 Jul; 136(1):114-6. Karpf DB, Yamashita S, Melmed S, Kudish H, Braunstein GD. PMID: 3712595.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    401. Effects of insulin on rat anterior pituitary cells. Inhibition of growth hormone secretion and mRNA levels. Diabetes. 1986 Apr; 35(4):440-7. Yamashita S, Melmed S. PMID: 3082700.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    402. Insulin-like growth factor-I action on hypothyroid rat pituitary cells: suppression of triiodothyronine-induced growth hormone secretion and messenger ribonucleic acid levels. Endocrinology. 1986 Apr; 118(4):1483-90. Melmed S, Yamashita S. PMID: 3948790.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    403. Autoregulation of pituitary growth hormone messenger ribonucleic acid levels in rats bearing transplantable mammosomatotrophic pituitary tumors. Endocrinology. 1986 Mar; 118(3):915-8. Yamashita S, Slanina S, Kado H, Melmed S. PMID: 3948780.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    404. Isolation and characterization of rat-mouse somatic cell hybrids secreting growth hormone and prolactin. Exp Cell Res. 1986 Feb; 162(2):475-85. Melmed S, Fagin JA. PMID: 3510881.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    405. Insulin-like growth factor I action on rat anterior pituitary cells: suppression of growth hormone secretion and messenger ribonucleic acid levels. Endocrinology. 1986 Jan; 118(1):176-82. Yamashita S, Melmed S. PMID: 3079701.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    406. Insulin suppresses triiodothyronine-induced growth hormone secretion by GH3 rat pituitary cells. Endocrinology. 1985 Aug; 117(2):532-7. Melmed S, Slanina SM. PMID: 3893986.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    407. Cardiac morphology in rats with growth hormone-producing tumours. J Mol Cell Cardiol. 1985 Aug; 17(8):805-11. Gilbert PL, Siegel RJ, Melmed S, Sherman CT, Fishbein MC. PMID: 2931534.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    408. Insulin suppresses rat growth hormone messenger ribonucleic acid levels in rat pituitary tumor cells. Diabetes. 1985 Apr; 34(4):409-12. Melmed S, Neilson L, Slanina S. PMID: 3882504.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    409. Acromegaly due to secretion of growth hormone by an ectopic pancreatic islet-cell tumor. N Engl J Med. 1985 Jan 03; 312(1):9-17. Melmed S, Ezrin C, Kovacs K, Goodman RS, Frohman LA. PMID: 2981107.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    410. Localization of somatostatin receptors in secretion vesicles in anterior pituitary cells and pancreatic islets. J Recept Res. 1985; 5(1):83-103. Draznin B, Mehler PS, Leitner JW, Sussman KE, Dahl R, Vatter A, Melmed S. PMID: 2860248.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    411. Insulin suppresses growth hormone secretion by rat pituitary cells. J Clin Invest. 1984 May; 73(5):1425-33. Melmed S. PMID: 6371058; PMCID: PMC425166.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    412. Hepatocyte insulin binding and action in rats with somatomammotrophic tumours. Diabetologia. 1983 Jul; 25(1):60-5. Davidson MB, Melmed S. PMID: 6350086.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    413. Dopaminergic regulation of prolactin and growth hormone synthesis in rat pituitary tumor cells. Brain Res. 1983 Jun 27; 270(1):165-8. Cheung CY, Melmed S, Braunstein GD. PMID: 6871710.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    414. Isolation of human-mouse somatic cell hybrids producing human prolactin: dominant expression of hormone secretion and regulation. J Clin Endocrinol Metab. 1983 Jun; 56(6):1145-51. Melmed S. PMID: 6404919.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    415. Human chorionic gonadotropin stimulates proliferation of Nb 2 rat lymphoma cells. J Clin Endocrinol Metab. 1983 May; 56(5):1068-70. Melmed S, Braunstein GD. PMID: 6187762.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    416. Pathophysiology of acromegaly. Endocr Rev. 1983; 4(3):271-90. Melmed S, Braunstein GD, Horvath E, Ezrin C, Kovacs K. PMID: 6354702.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    417. Establishment of functional human pituitary tumor cell cultures. In Vitro. 1982 Jan; 18(1):35-42. Melmed S, Odenheimer D, Carlson HE, Hershman JM. PMID: 6820653.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    418. Histidyl-proline diketopiperazine suppresses prolactin secretion in human pituitary tumour cell cultures. Clin Endocrinol (Oxf). 1982 Jan; 16(1):97-100. Melmed S, Carlson HE, Hershman JM. PMID: 7074974.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    419. myo-inositol in the reproductive tract of the female rat. Int J Biochem. 1982; 14(2):147-50. Lewin LM, Yannai Y, Melmed S, Weiss M. PMID: 7200041.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    420. Bromocriptine inhibits colony formation by rat pituitary tumor cells in a double-layered agar clonogenic assay. Endocrinology. 1981 Dec; 109(6):2258-60. Melmed S. PMID: 7308152.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    421. Glutathione-dependent thyroxine 5'-monodeiodination modulates growth hormone production by cultured nonthyrotropic rat pituitary cells. Endocrinology. 1981 Mar; 108(3):970-6. Melmed S, Nelson M, Kaplowitz N, Yamada T, Hershman JM. PMID: 7460854.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    422. Suppression of thyrotropin by 3,5-dimethyl-3'-isopropyl-L-thyronine in euthyroid and hypothyroid rats. Endocrinology. 1980 Oct; 107(4):1050-4. Melmed S, Spira O, Gordon A, Gross J, Jorgensen EC, Hershman JM. PMID: 7408758.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    423. A prolactin inhibitory factor with immunocharacteristics similar to thyrotropin releasing factor (TRH) is present in rat pituitary tumors (GH3 and W5), testicular tissue and a plant material, alfalfa. Biochem Biophys Res Commun. 1980 Sep 16; 96(1):47-53. Morley JE, Meyer N, Pekary AE, Melmed S, Carlson HE, Briggs JE, Hershman JM. PMID: 6776954.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    424. Cell culture alters the hormonal response of rat pituitary tumors to dynamic stimulation. Endocrinology. 1980 Sep; 107(3):789-93. Melmed S, Carlson HE, Briggs J, Hershman JM. PMID: 6105070.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    425. Endocrine effects of naloxone-induced opiate receptor blockade. J Clin Endocrinol Metab. 1980 Feb; 50(2):251-7. Morley JE, Baranetsky NG, Wingert TD, Carlson HE, Hershman JM, Melmed S, Levin SR, Jamison KR, Weitzman R, Chang RJ, Varner AA. PMID: 6243662.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    426. Autofeedback of prolactin in cultured prolactin-secreting pituitary cells. Horm Res. 1980; 12(6):340-4. Melmed S, Carlson HE, Briggs J, Hershman JM. PMID: 7419165.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    427. Cholecystokinin octapeptide releases growth hormone from the pituitary in vitro. Life Sci. 1979 Oct 01; 25(14):1201-5. Morley JE, Melmed S, Briggs J, Carlson HE, Hershman JM, Solomon TE, Lamers C, Damassa DA. PMID: 513954.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    428. Fetal response to thyrotropin-releasing hormone after thyroid hormone administration to the rhesus monkey: lack of pituitary suppression. Endocrinology. 1979 Aug; 105(2):334-41. Melmed S, Harada A, Murata Y, Socol M, Reed A, Carlson HE, Azukizawa M, Martin C, Jorgensen E, Hershman JM. PMID: 110579.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
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