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Melmed, Shlomo K

Title(s)Professor-in-Residence, Medicine
SchoolEndocrinology
Phone(310) 423-4691
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Melmed S. Pituitary-Tumor Endocrinopathies. N Engl J Med. 2020 03 05; 382(10):937-950. PMID: 32130815.
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    2. Chesnokova V, Melmed S. Growth hormone in the tumor microenvironment. Arch Endocrinol Metab. 2019 Nov-Dec; 63(6):568-575. PMID: 31939481.
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    3. Melmed S. Pathogenesis and Diagnosis of Growth Hormone Deficiency in Adults. N Engl J Med. 2019 06 27; 380(26):2551-2562. PMID: 31242363.
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    4. Chesnokova V, Zonis S, Barrett RJ, Gleeson JP, Melmed S. Growth Hormone Induces Colon DNA Damage Independent of IGF-1. Endocrinology. 2019 06 01; 160(6):1439-1447. PMID: 31002310.
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    5. Kameda H, Yamamoto M, Tone Y, Tone M, Melmed S. Proton Sensitivity of Corticotropin-Releasing Hormone Receptor 1 Signaling to Proopiomelanocortin in Male Mice. Endocrinology. 2019 02 01; 160(2):276-291. PMID: 30535142.
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    6. Günther T, Tulipano G, Dournaud P, Bousquet C, Csaba Z, Kreienkamp HJ, Lupp A, Korbonits M, Castaño JP, Wester HJ, Culler M, Melmed S, Schulz S. International Union of Basic and Clinical Pharmacology. CV. Somatostatin Receptors: Structure, Function, Ligands, and New Nomenclature. Pharmacol Rev. 2018 10; 70(4):763-835. PMID: 30232095.
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    7. Melmed S, Bronstein MD, Chanson P, Klibanski A, Casanueva FF, Wass JAH, Strasburger CJ, Luger A, Clemmons DR, Giustina A. A Consensus Statement on acromegaly therapeutic outcomes. Nat Rev Endocrinol. 2018 09; 14(9):552-561. PMID: 30050156.
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    8. Labadzhyan A, Kim SM, Rhyu J, Araki T, Mahtabifard A, Melmed S. THYMIC CARCINOID WITH ADRENOCORTICOTROPIC HORMONE-PRODUCING ECTOPIC CUSHING SYNDROME AND EMPTY SELLA. AACE Clin Case Rep. 2018 Sep-Oct; 4(5):e375-e378. PMID: 31897433.
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    9. Babu H, Ortega A, Nuno M, Dehghan A, Schweitzer A, Bonert HV, Carmichael JD, Cooper O, Melmed S, Mamelak AN. Long-Term Endocrine Outcomes Following Endoscopic Endonasal Transsphenoidal Surgery for Acromegaly and Associated Prognostic Factors. Neurosurgery. 2017 Aug 01; 81(2):357-366. PMID: 28368500.
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    10. Melmed S. Melvin M. Grumbach 1925-2016. Proc Natl Acad Sci U S A. 2017 05 09; 114(19):4845-4847. PMID: 28439029.
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    11. Cooper O, Bonert V, Moser F, Mirocha J, Melmed S. Altered Pituitary Gland Structure and Function in Posttraumatic Stress Disorder. J Endocr Soc. 2017 Jun 01; 1(6):577-587. PMID: 29264511.
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    12. Ben-Shlomo A, Liu NA, Melmed S. Somatostatin and dopamine receptor regulation of pituitary somatotroph adenomas. Pituitary. 2017 Feb; 20(1):93-99. PMID: 27900635.
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    13. Fleseriu M, Hashim IA, Karavitaki N, Melmed S, Murad MH, Salvatori R, Samuels MH. Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2016 Nov; 101(11):3888-3921. PMID: 27736313.
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    14. Chesnokova V, Zonis S, Zhou C, Recouvreux MV, Ben-Shlomo A, Araki T, Barrett R, Workman M, Wawrowsky K, Ljubimov VA, Uhart M, Melmed S. Growth hormone is permissive for neoplastic colon growth. Proc Natl Acad Sci U S A. 2016 Jun 07; 113(23):E3250-9. PMID: 27226307.
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    15. Melmed S. Pituitary Medicine From Discovery to Patient-Focused Outcomes. J Clin Endocrinol Metab. 2016 Mar; 101(3):769-77. PMID: 26908107.
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    16. Melmed S. New therapeutic agents for acromegaly. Nat Rev Endocrinol. 2016 Feb; 12(2):90-8. PMID: 26610414.
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    17. Liu NA, Araki T, Cuevas-Ramos D, Hong J, Ben-Shlomo A, Tone Y, Tone M, Melmed S. Cyclin E-Mediated Human Proopiomelanocortin Regulation as a Therapeutic Target for Cushing Disease. J Clin Endocrinol Metab. 2015 Jul; 100(7):2557-64. PMID: 25942479.
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    18. Melmed S. Pituitary tumors. Endocrinol Metab Clin North Am. 2015 Mar; 44(1):1-9. PMID: 25732636.
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    19. Melmed S, Popovic V, Bidlingmaier M, Mercado M, van der Lely AJ, Biermasz N, Bolanowski M, Coculescu M, Schopohl J, Racz K, Glaser B, Goth M, Greenman Y, Trainer P, Mezosi E, Shimon I, Giustina A, Korbonits M, Bronstein MD, Kleinberg D, Teichman S, Gliko-Kabir I, Mamluk R, Haviv A, Strasburger C. Safety and efficacy of oral octreotide in acromegaly: results of a multicenter phase III trial. J Clin Endocrinol Metab. 2015 Apr; 100(4):1699-708. PMID: 25664604.
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    20. Cuevas-Ramos D, Carmichael JD, Cooper O, Bonert VS, Gertych A, Mamelak AN, Melmed S. A structural and functional acromegaly classification. J Clin Endocrinol Metab. 2015 Jan; 100(1):122-31. PMID: 25250634.
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    21. Liu X, Kano M, Araki T, Cooper O, Fukuoka H, Tone Y, Tone M, Melmed S. ErbB receptor-driven prolactinomas respond to targeted lapatinib treatment in female transgenic mice. Endocrinology. 2015 Jan; 156(1):71-9. PMID: 25375038.
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    22. Katznelson L, Laws ER, Melmed S, Molitch ME, Murad MH, Utz A, Wass JA. Acromegaly: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2014 Nov; 99(11):3933-51. PMID: 25356808.
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    23. Melmed S, Kleinberg DL, Bonert V, Fleseriu M. Acromegaly: assessing the disorder and navigating therapeutic options for treatment. Endocr Pract. 2014 Oct; 20 Suppl 1:7-17; quiz 18-20. PMID: 25374336.
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    24. Melmed S, Vari SG. Challenges in life sciences and health systems in the 21st century. Croat Med J. 2014 Jun 01; 55(3):184-5. PMID: 24891276.
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    25. Carmichael JD, Bonert VS, Nuño M, Ly D, Melmed S. Acromegaly clinical trial methodology impact on reported biochemical efficacy rates of somatostatin receptor ligand treatments: a meta-analysis. J Clin Endocrinol Metab. 2014 May; 99(5):1825-33. PMID: 24606084.
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    26. Eigler T, Ben-Shlomo A, Zhou C, Khalafi R, Ren SG, Melmed S. Constitutive somatostatin receptor subtype-3 signaling suppresses growth hormone synthesis. Mol Endocrinol. 2014 Apr; 28(4):554-64. PMID: 24606125.
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    27. Donangelo I, Ren SG, Eigler T, Svendsen C, Melmed S. Sca1? murine pituitary adenoma cells show tumor-growth advantage. Endocr Relat Cancer. 2014 Apr; 21(2):203-16. PMID: 24481638.
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    28. Mamelak AN, Carmichael J, Bonert VH, Cooper O, Melmed S. Single-surgeon fully endoscopic endonasal transsphenoidal surgery: outcomes in three-hundred consecutive cases. Pituitary. 2013 Sep; 16(3):393-401. PMID: 23011322.
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    29. Chesnokova V, Zhou C, Ben-Shlomo A, Zonis S, Tani Y, Ren SG, Melmed S. Growth hormone is a cellular senescence target in pituitary and nonpituitary cells. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):E3331-9. PMID: 23940366.
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    30. Ben-Shlomo A, Pichurin O, Khalafi R, Zhou C, Chesnokova V, Ren SG, Liu NA, Melmed S. Constitutive somatostatin receptor subtype 2 activity attenuates GH synthesis. Endocrinology. 2013 Jul; 154(7):2399-409. PMID: 23696564.
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    31. Melmed S. Idiopathic adult growth hormone deficiency. J Clin Endocrinol Metab. 2013 Jun; 98(6):2187-97. PMID: 23539718.
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    32. Chesnokova V, Zonis S, Wawrowsky K, Tani Y, Ben-Shlomo A, Ljubimov V, Mamelak A, Bannykh S, Melmed S. Clusterin and FOXL2 act concordantly to regulate pituitary gonadotroph adenoma growth. Mol Endocrinol. 2012 Dec; 26(12):2092-103. PMID: 23051594.
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    33. Toledano Y, Zonis S, Ren SG, Wawrowsky K, Chesnokova V, Melmed S. Estradiol partially recapitulates murine pituitary cell cycle response to pregnancy. Endocrinology. 2012 Oct; 153(10):5011-22. PMID: 22851678.
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    34. Gruszka A, Culler MD, Melmed S. Somatostatin analogs and chimeric somatostatin-dopamine molecules differentially regulate human growth hormone and prolactin gene expression and secretion in vitro. Mol Cell Endocrinol. 2012 Oct 15; 362(1-2):104-9. PMID: 22705877.
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    35. Tong Y, Zheng Y, Zhou J, Oyesiku NM, Koeffler HP, Melmed S. Genomic characterization of human and rat prolactinomas. Endocrinology. 2012 Aug; 153(8):3679-91. PMID: 22635680.
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    36. Cooper O, Melmed S. Subclinical hyperfunctioning pituitary adenomas: the silent tumors. Best Pract Res Clin Endocrinol Metab. 2012 Aug; 26(4):447-60. PMID: 22863387.
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    37. Fukuoka H, Cooper O, Ben-Shlomo A, Mamelak A, Ren SG, Bruyette D, Melmed S. EGFR as a therapeutic target for human, canine, and mouse ACTH-secreting pituitary adenomas. J Clin Invest. 2011 Dec; 121(12):4712-21. PMID: 22105169.
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    38. Cooper O, Vlotides G, Fukuoka H, Greene MI, Melmed S. Expression and function of ErbB receptors and ligands in the pituitary. Endocr Relat Cancer. 2011 Oct; 18(6):R197-211. PMID: 21917845.
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    39. Tong Y, Zhao W, Zhou C, Wawrowsky K, Melmed S. PTTG1 attenuates drug-induced cellular senescence. PLoS One. 2011; 6(8):e23754. PMID: 21858218.
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    40. Liu NA, Jiang H, Ben-Shlomo A, Wawrowsky K, Fan XM, Lin S, Melmed S. Targeting zebrafish and murine pituitary corticotroph tumors with a cyclin-dependent kinase (CDK) inhibitor. Proc Natl Acad Sci U S A. 2011 May 17; 108(20):8414-9. PMID: 21536883.
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    41. Chesnokova V, Zonis S, Zhou C, Ben-Shlomo A, Wawrowsky K, Toledano Y, Tong Y, Kovacs K, Scheithauer B, Melmed S. Lineage-specific restraint of pituitary gonadotroph cell adenoma growth. PLoS One. 2011 Mar 25; 6(3):e17924. PMID: 21464964.
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    42. Melmed S. Pathogenesis of pituitary tumors. Nat Rev Endocrinol. 2011 May; 7(5):257-66. PMID: 21423242.
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    43. Fukuoka H, Cooper O, Mizutani J, Tong Y, Ren SG, Bannykh S, Melmed S. HER2/ErbB2 receptor signaling in rat and human prolactinoma cells: strategy for targeted prolactinoma therapy. Mol Endocrinol. 2011 Jan; 25(1):92-103. PMID: 21106881.
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    44. Cooper O, Ben-Shlomo A, Bonert V, Bannykh S, Mirocha J, Melmed S. Silent corticogonadotroph adenomas: clinical and cellular characteristics and long-term outcomes. Horm Cancer. 2010 Apr; 1(2):80-92. PMID: 20717480.
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    45. Chesnokova V, Melmed S. Pituitary senescence: the evolving role of Pttg. Mol Cell Endocrinol. 2010 Sep 15; 326(1-2):55-9. PMID: 20153804.
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    46. Yu R, Melmed S. Pathogenesis of pituitary tumors. Prog Brain Res. 2010; 182:207-27. PMID: 20541667.
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    47. Melmed S. Acromegaly pathogenesis and treatment. J Clin Invest. 2009 Nov; 119(11):3189-202. PMID: 19884662.
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    48. Zhou C, Wawrowsky K, Bannykh S, Gutman S, Melmed S. E2F1 induces pituitary tumor transforming gene (PTTG1) expression in human pituitary tumors. Mol Endocrinol. 2009 Dec; 23(12):2000-12. PMID: 19837943.
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    49. Melmed S, Cook D, Schopohl J, Goth MI, Lam KS, Marek J. Rapid and sustained reduction of serum growth hormone and insulin-like growth factor-1 in patients with acromegaly receiving lanreotide Autogel therapy: a randomized, placebo-controlled, multicenter study with a 52 week open extension. Pituitary. 2010; 13(1):18-28. PMID: 19639415.
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    50. Chesnokova V, Melmed S. Pituitary tumour-transforming gene (PTTG) and pituitary senescence. Horm Res. 2009 Apr; 71 Suppl 2:82-7. PMID: 19407503.
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    51. Vlotides G, Cooper O, Chen YH, Ren SG, Greenman Y, Melmed S. Heregulin regulates prolactinoma gene expression. Cancer Res. 2009 May 15; 69(10):4209-16. PMID: 19401448.
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    52. Vlotides G, Chen YH, Eigler T, Ren SG, Melmed S. Fibroblast growth factor-2 autofeedback regulation in pituitary folliculostellate TtT/GF cells. Endocrinology. 2009 Jul; 150(7):3252-8. PMID: 19359387.
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    53. Ben-Shlomo A, Zhou C, Pichurin O, Chesnokova V, Liu NA, Culler MD, Melmed S. Constitutive somatostatin receptor activity determines tonic pituitary cell response. Mol Endocrinol. 2009 Mar; 23(3):337-48. PMID: 19131507.
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    54. Carmichael JD, Bonert VS, Mirocha JM, Melmed S. The utility of oral glucose tolerance testing for diagnosis and assessment of treatment outcomes in 166 patients with acromegaly. J Clin Endocrinol Metab. 2009 Feb; 94(2):523-7. PMID: 19033371.
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    55. Chesnokova V, Zonis S, Kovacs K, Ben-Shlomo A, Wawrowsky K, Bannykh S, Melmed S. p21(Cip1) restrains pituitary tumor growth. Proc Natl Acad Sci U S A. 2008 Nov 11; 105(45):17498-503. PMID: 18981426.
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    56. Vlotides G, Siegel E, Donangelo I, Gutman S, Ren SG, Melmed S. Rat prolactinoma cell growth regulation by epidermal growth factor receptor ligands. Cancer Res. 2008 Aug 01; 68(15):6377-86. PMID: 18676863.
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    57. Bonert VS, Kennedy L, Petersenn S, Barkan A, Carmichael J, Melmed S. Lipodystrophy in patients with acromegaly receiving pegvisomant. J Clin Endocrinol Metab. 2008 Sep; 93(9):3515-8. PMID: 18611977.
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    58. Zhou C, Tong Y, Wawrowsky K, Bannykh S, Donangelo I, Melmed S. Oct-1 induces pituitary tumor transforming gene expression in endocrine tumors. Endocr Relat Cancer. 2008 Sep; 15(3):817-31. PMID: 18550719.
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    59. Liu NA, Ren M, Song J, Ríos Y, Wawrowsky K, Ben-Shlomo A, Lin S, Melmed S. In vivo time-lapse imaging delineates the zebrafish pituitary proopiomelanocortin lineage boundary regulated by FGF3 signal. Dev Biol. 2008 Jul 15; 319(2):192-200. PMID: 18514643.
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    60. Ben-Shlomo A, Melmed S. Acromegaly. Endocrinol Metab Clin North Am. 2008 Mar; 37(1):101-22, viii. PMID: 18226732.
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    61. Cooper O, Geller JL, Melmed S. Ovarian hyperstimulation syndrome caused by an FSH-secreting pituitary adenoma. Nat Clin Pract Endocrinol Metab. 2008 Apr; 4(4):234-8. PMID: 18268519.
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    62. Melmed GY, Devlin SM, Vlotides G, Dhall D, Ross S, Yu R, Melmed S. Anti-aging therapy with human growth hormone associated with metastatic colon cancer in a patient with Crohn's colitis. Clin Gastroenterol Hepatol. 2008 Mar; 6(3):360-3. PMID: 18255351.
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    63. Melmed S. Update in pituitary disease. J Clin Endocrinol Metab. 2008 Feb; 93(2):331-8. PMID: 18258780.
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    64. Ben-Shlomo A, Melmed S. Pasireotide--a somatostatin analog for the potential treatment of acromegaly, neuroendocrine tumors and Cushing's disease. IDrugs. 2007 Dec; 10(12):885-95. PMID: 18041687.
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    65. Ben-Shlomo A, Melmed S. Somatostatin agonists for treatment of acromegaly. Mol Cell Endocrinol. 2008 May 14; 286(1-2):192-8. PMID: 18191325.
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    66. Chesnokova V, Zonis S, Rubinek T, Yu R, Ben-Shlomo A, Kovacs K, Wawrowsky K, Melmed S. Senescence mediates pituitary hypoplasia and restrains pituitary tumor growth. Cancer Res. 2007 Nov 01; 67(21):10564-72. PMID: 17975001.
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    67. Gruszka A, Ren SG, Dong J, Culler MD, Melmed S. Regulation of growth hormone and prolactin gene expression and secretion by chimeric somatostatin-dopamine molecules. Endocrinology. 2007 Dec; 148(12):6107-14. PMID: 17656461.
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    68. Rubinek T, Chesnokova V, Wolf I, Wawrowsky K, Vlotides G, Melmed S. Discordant proliferation and differentiation in pituitary tumor-transforming gene-null bone marrow stem cells. Am J Physiol Cell Physiol. 2007 Sep; 293(3):C1082-92. PMID: 17626243.
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    69. Vlotides G, Eigler T, Melmed S. Pituitary tumor-transforming gene: physiology and implications for tumorigenesis. Endocr Rev. 2007 Apr; 28(2):165-86. PMID: 17325339.
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    70. Melmed S. Medical progress: Acromegaly. N Engl J Med. 2006 Dec 14; 355(24):2558-73. PMID: 17167139.
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    71. Yu R, Bonert V, Saporta I, Raffel LJ, Melmed S. Aryl hydrocarbon receptor interacting protein variants in sporadic pituitary adenomas. J Clin Endocrinol Metab. 2006 Dec; 91(12):5126-9. PMID: 17018653.
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    72. Yu R, Cruz-Soto M, Li Calzi S, Hui H, Melmed S. Murine pituitary tumor-transforming gene functions as a securin protein in insulin-secreting cells. J Endocrinol. 2006 Oct; 191(1):45-53. PMID: 17065388.
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    73. Bonert VS, Melmed S. Acromegaly with moderate hyperprolactinemia caused by an intrasellar macroadenoma. Nat Clin Pract Endocrinol Metab. 2006 Jul; 2(7):408-12; quiz following 412. PMID: 16932323.
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    74. Donangelo I, Gutman S, Horvath E, Kovacs K, Wawrowsky K, Mount M, Melmed S. Pituitary tumor transforming gene overexpression facilitates pituitary tumor development. Endocrinology. 2006 Oct; 147(10):4781-91. PMID: 16809444.
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    75. Ren SG, Melmed S. Pyridoxal phosphate inhibits pituitary cell proliferation and hormone secretion. Endocrinology. 2006 Aug; 147(8):3936-42. PMID: 16690808.
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    76. Yu R, Bonert V, Cruz-Soto M, Melmed S. Cyclin-dependent kinase inhibitor gene polymorphisms in pituitary gigantism. Endocrine. 2006 Feb; 29(1):119-20. PMID: 16622299.
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    77. Donangelo I, Melmed S. Implication of pituitary tropic status on tumor development. Front Horm Res. 2006; 35:1-8. PMID: 16809918.
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    78. Liu NA, Liu Q, Wawrowsky K, Yang Z, Lin S, Melmed S. Prolactin receptor signaling mediates the osmotic response of embryonic zebrafish lactotrophs. Mol Endocrinol. 2006 Apr; 20(4):871-80. PMID: 16339273.
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    79. Donangelo I, Melmed S. Treatment of acromegaly: future. Endocrine. 2005 Oct; 28(1):123-8. PMID: 16311419.
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    80. Akino K, Akita S, Mizuguchi T, Takumi I, Yu R, Wang XY, Rozga J, Demetriou AA, Melmed S, Ohtsuru A, Yamashita S. A novel molecular marker of pituitary tumor transforming gene involves in a rat liver regeneration. J Surg Res. 2005 Nov; 129(1):142-6. PMID: 15936773.
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    81. Chesnokova V, Kovacs K, Castro AV, Zonis S, Melmed S. Pituitary hypoplasia in Pttg-/- mice is protective for Rb+/- pituitary tumorigenesis. Mol Endocrinol. 2005 Sep; 19(9):2371-9. PMID: 15919720.
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    82. Melmed S, Sternberg R, Cook D, Klibanski A, Chanson P, Bonert V, Vance ML, Rhew D, Kleinberg D, Barkan A. A critical analysis of pituitary tumor shrinkage during primary medical therapy in acromegaly. J Clin Endocrinol Metab. 2005 Jul; 90(7):4405-10. PMID: 15827109.
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    83. Abbud RA, Takumi I, Barker EM, Ren SG, Chen DY, Wawrowsky K, Melmed S. Early multipotential pituitary focal hyperplasia in the alpha-subunit of glycoprotein hormone-driven pituitary tumor-transforming gene transgenic mice. Mol Endocrinol. 2005 May; 19(5):1383-91. PMID: 15677710.
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    84. Bonert VS, Elashoff JD, Barnett P, Melmed S. Body mass index determines evoked growth hormone (GH) responsiveness in normal healthy male subjects: diagnostic caveat for adult GH deficiency. J Clin Endocrinol Metab. 2004 Jul; 89(7):3397-401. PMID: 15240621.
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    85. Murray RD, Kim K, Ren SG, Lewis I, Weckbecker G, Bruns C, Melmed S. The novel somatostatin ligand (SOM230) regulates human and rat anterior pituitary hormone secretion. J Clin Endocrinol Metab. 2004 Jun; 89(6):3027-32. PMID: 15181094.
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    86. Heaney AP, Melmed S. Molecular targets in pituitary tumours. Nat Rev Cancer. 2004 Apr; 4(4):285-95. PMID: 15057288.
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    87. Yu R, Melmed S. Pituitary tumor transforming gene: an update. Front Horm Res. 2004; 32:175-85. PMID: 15281346.
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    88. Melmed S. Mechanisms for pituitary tumorigenesis: the plastic pituitary. J Clin Invest. 2003 Dec; 112(11):1603-18. PMID: 14660734.
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    89. Ren SG, Kim S, Taylor J, Dong J, Moreau JP, Culler MD, Melmed S. Suppression of rat and human growth hormone and prolactin secretion by a novel somatostatin/dopaminergic chimeric ligand. J Clin Endocrinol Metab. 2003 Nov; 88(11):5414-21. PMID: 14602782.
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    90. Abbud RA, Kelleher R, Melmed S. Cell-specific pituitary gene expression profiles after treatment with leukemia inhibitory factor reveal novel modulators for proopiomelanocortin expression. Endocrinology. 2004 Feb; 145(2):867-80. PMID: 14576184.
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    91. Ren SG, Taylor J, Dong J, Yu R, Culler MD, Melmed S. Functional association of somatostatin receptor subtypes 2 and 5 in inhibiting human growth hormone secretion. J Clin Endocrinol Metab. 2003 Sep; 88(9):4239-45. PMID: 12970293.
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    92. Yu R, Lu W, Chen J, McCabe CJ, Melmed S. Overexpressed pituitary tumor-transforming gene causes aneuploidy in live human cells. Endocrinology. 2003 Nov; 144(11):4991-8. PMID: 12960092.
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    93. Heaney AP, Fernando M, Melmed S. PPAR-gamma receptor ligands: novel therapy for pituitary adenomas. J Clin Invest. 2003 May; 111(9):1381-8. PMID: 12727930.
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    94. Wang Z, Moro E, Kovacs K, Yu R, Melmed S. Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic beta cell proliferation and diabetes. Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6):3428-32. PMID: 12626748.
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    95. Ben-Shlomo A, Melmed S. Clinical review 154: The role of pharmacotherapy in perioperative management of patients with acromegaly. J Clin Endocrinol Metab. 2003 Mar; 88(3):963-8. PMID: 12629068.
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    96. Liu NA, Huang H, Yang Z, Herzog W, Hammerschmidt M, Lin S, Melmed S. Pituitary corticotroph ontogeny and regulation in transgenic zebrafish. Mol Endocrinol. 2003 May; 17(5):959-66. PMID: 12576489.
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    97. Ben-Shlomo A, Miklovsky I, Ren SG, Yong WH, Heaney AP, Culler MD, Melmed S. Leukemia inhibitory factor regulates prolactin secretion in prolactinoma and lactotroph cells. J Clin Endocrinol Metab. 2003 Feb; 88(2):858-63. PMID: 12574225.
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    98. Horwitz GA, Miklovsky I, Heaney AP, Ren SG, Melmed S. Human pituitary tumor-transforming gene (PTTG1) motif suppresses prolactin expression. Mol Endocrinol. 2003 Apr; 17(4):600-9. PMID: 12554778.
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    99. Stoika R, Melmed S. Expression and function of pituitary tumour transforming gene for T-lymphocyte activation. Br J Haematol. 2002 Dec; 119(4):1070-4. PMID: 12472590.
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    100. Heaney AP, Fernando M, Yong WH, Melmed S. Functional PPAR-gamma receptor is a novel therapeutic target for ACTH-secreting pituitary adenomas. Nat Med. 2002 Nov; 8(11):1281-7. PMID: 12379847.
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    101. Chesnokova V, Kariagina A, Melmed S. Opposing effects of pituitary leukemia inhibitory factor and SOCS-3 on the ACTH axis response to inflammation. Am J Physiol Endocrinol Metab. 2002 May; 282(5):E1110-8. PMID: 11934677.
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    102. Chesnokova V, Melmed S. Minireview: Neuro-immuno-endocrine modulation of the hypothalamic-pituitary-adrenal (HPA) axis by gp130 signaling molecules. Endocrinology. 2002 May; 143(5):1571-4. PMID: 11956136.
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    103. Heaney AP, Fernando M, Melmed S. Functional role of estrogen in pituitary tumor pathogenesis. J Clin Invest. 2002 Jan; 109(2):277-83. PMID: 11805140.
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    104. Melmed S, Vance ML, Barkan AL, Bengtsson BA, Kleinberg D, Klibanski A, Trainer PJ. Current status and future opportunities for controlling acromegaly. Pituitary. 2002; 5(3):185-96. PMID: 12812311.
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    105. Pei L, Melmed S. The neurofibromatosis gene in human pituitary adenomas. Endocr Pathol. 1994 Dec; 5(4):229-232. PMID: 32138455.
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