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GIP receptor antagonism eliminates paradoxical growth hormone secretion in some patients with acromegaly. J Clin Endocrinol Metab. 2024 Aug 22.
Jensen MH, Gasbjerg LS, Skov-Jeppesen K, Jacobsen JCB, Poulsen SS, Zhou C, Jakubauskaite R, Poulsen FR, Bonde C, Albarazi M, Halle B, Christiansen CB, Sanni SJ, Byberg S, Hoe B, Holst JJ, Dela F, Rasmussen AK, Knop FK, Arlien-Søborg MC, Melmed S, Jørgensen JOL, Andersen MS, Hartmann B, Klose MC, Feldt-Rasmussen U, Sparre-Ulrich AH, Rosenkilde MM. PMID: 39172542.
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WIP1 is a novel specific target for growth hormone action. iScience. 2023 Nov 17; 26(11):108117.
Apaydin T, Zonis S, Zhou C, Valencia CW, Barrett R, Strous GJ, Mol JA, Chesnokova V, Melmed S. PMID: 37876819; PMCID: PMC10590974.
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Pituitary Somatotroph Adenoma-derived Exosomes: Characterization of Nonhormonal Actions. J Clin Endocrinol Metab. 2022 01 18; 107(2):379-397.
Zhou C, Shen S, Moran R, Deng N, Marbán E, Melmed S. PMID: 34467411; PMCID: PMC8764361.
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7 Fields:
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HumansAnimalsCells
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Pituitary Tumor Transforming Gene 1 Orchestrates Gene Regulatory Variation in Mouse Ventral Midbrain During Aging. Front Genet. 2020; 11:566734.
Gui Y, Thomas MH, Garcia P, Karout M, Halder R, Michelucci A, Kollmus H, Zhou C, Melmed S, Schughart K, Balling R, Mittelbronn M, Nadeau JH, Williams RW, Sauter T, Buttini M, Sinkkonen L. PMID: 33173537; PMCID: PMC7538689.
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Growth hormone is permissive for neoplastic colon growth. Proc Natl Acad Sci U S A. 2016 Jun 07; 113(23):E3250-9.
Chesnokova V, Zonis S, Zhou C, Recouvreux MV, Ben-Shlomo A, Araki T, Barrett R, Workman M, Wawrowsky K, Ljubimov VA, Uhart M, Melmed S. PMID: 27226307; PMCID: PMC4988562.
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54 Fields:
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HumansAnimalsCells
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Cell-free circulating tumor DNA in cancer. Chin J Cancer. 2016 Apr 07; 35:36.
Qin Z, Ljubimov VA, Zhou C, Tong Y, Liang J. PMID: 27056366; PMCID: PMC4823888.
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61 Fields:
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HumansCells
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STAT3 upregulation in pituitary somatotroph adenomas induces growth hormone hypersecretion. J Clin Invest. 2015 Apr; 125(4):1692-702.
Zhou C, Jiao Y, Wang R, Ren SG, Wawrowsky K, Melmed S. PMID: 25774503; PMCID: PMC4396466.
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29 Fields:
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HumansAnimalsCells
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Pituitary tumor-transforming gene 1 regulates the patterning of retinal mosaics. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):9295-300.
Keeley PW, Zhou C, Lu L, Williams RW, Melmed S, Reese BE. PMID: 24927528; PMCID: PMC4078852.
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18 Fields:
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AnimalsCells
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Constitutive somatostatin receptor subtype-3 signaling suppresses growth hormone synthesis. Mol Endocrinol. 2014 Apr; 28(4):554-64.
Eigler T, Ben-Shlomo A, Zhou C, Khalafi R, Ren SG, Melmed S. PMID: 24606125; PMCID: PMC3968402.
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11 Fields:
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HumansAnimalsCells
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Growth hormone is a cellular senescence target in pituitary and nonpituitary cells. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):E3331-9.
Chesnokova V, Zhou C, Ben-Shlomo A, Zonis S, Tani Y, Ren SG, Melmed S. PMID: 23940366; PMCID: PMC3761588.
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40 Fields:
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HumansAnimalsCells
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Constitutive somatostatin receptor subtype 2 activity attenuates GH synthesis. Endocrinology. 2013 Jul; 154(7):2399-409.
Ben-Shlomo A, Pichurin O, Khalafi R, Zhou C, Chesnokova V, Ren SG, Liu NA, Melmed S. PMID: 23696564; PMCID: PMC3689284.
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PubMed Mentions:
8 Fields:
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HumansAnimalsCells
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PTTG1 attenuates drug-induced cellular senescence. PLoS One. 2011; 6(8):e23754.
Tong Y, Zhao W, Zhou C, Wawrowsky K, Melmed S. PMID: 21858218; PMCID: PMC3157437.
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11 Fields:
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HumansAnimalsCells
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Pancreatic neuroendocrine tumors in glucagon receptor-deficient mice. PLoS One. 2011; 6(8):e23397.
Yu R, Dhall D, Nissen NN, Zhou C, Ren SG. PMID: 21853126; PMCID: PMC3154424.
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25 Fields:
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HumansAnimals
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A natural inactivating mutant of human glucagon receptor exhibits multiple abnormalities in processing and signaling. Endocrinol Nutr. 2011 Jun-Jul; 58(6):258-66.
Yu R, Wawrowsky K, Zhou C. PMID: 21680267.
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5 Fields:
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HumansCells
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Lineage-specific restraint of pituitary gonadotroph cell adenoma growth. PLoS One. 2011 Mar 25; 6(3):e17924.
Chesnokova V, Zonis S, Zhou C, Ben-Shlomo A, Wawrowsky K, Toledano Y, Tong Y, Kovacs K, Scheithauer B, Melmed S. PMID: 21464964; PMCID: PMC3064664.
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19 Fields:
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HumansAnimalsCells
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Homozygous P86S mutation of the human glucagon receptor is associated with hyperglucagonemia, alpha cell hyperplasia, and islet cell tumor. Pancreas. 2009 Nov; 38(8):941-6.
Zhou C, Dhall D, Nissen NN, Chen CR, Yu R. PMID: 19657311; PMCID: PMC2767399.
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54 Fields:
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HumansCells
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E2F1 induces pituitary tumor transforming gene (PTTG1) expression in human pituitary tumors. Mol Endocrinol. 2009 Dec; 23(12):2000-12.
Zhou C, Wawrowsky K, Bannykh S, Gutman S, Melmed S. PMID: 19837943; PMCID: PMC2796149.
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19 Fields:
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HumansAnimalsCells
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PTTG overexpression promotes lymph node metastasis in human esophageal squamous cell carcinoma. Cancer Res. 2009 Apr 15; 69(8):3283-90.
Yan S, Zhou C, Lou X, Xiao Z, Zhu H, Wang Q, Wang Y, Lu N, He S, Zhan Q, Liu S, Xu N. PMID: 19351864.
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27 Fields:
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HumansAnimalsCells
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Constitutive somatostatin receptor activity determines tonic pituitary cell response. Mol Endocrinol. 2009 Mar; 23(3):337-48.
Ben-Shlomo A, Zhou C, Pichurin O, Chesnokova V, Liu NA, Culler MD, Melmed S. PMID: 19131507; PMCID: PMC2725764.
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13 Fields:
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HumansCells
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FRAT1 overexpression leads to aberrant activation of beta-catenin/TCF pathway in esophageal squamous cell carcinoma. Int J Cancer. 2008 Aug 01; 123(3):561-8.
Wang Y, Liu S, Zhu H, Zhang W, Zhang G, Zhou X, Zhou C, Quan L, Bai J, Xue L, Lu N, Xu N. PMID: 18498136.
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22 Fields:
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HumansCells
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beta-Catenin/TCF pathway upregulates STAT3 expression in human esophageal squamous cell carcinoma. Cancer Lett. 2008 Nov 18; 271(1):85-97.
Yan S, Zhou C, Zhang W, Zhang G, Zhao X, Yang S, Wang Y, Lu N, Zhu H, Xu N. PMID: 18602747.
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54 Fields:
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HumansCells
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Oct-1 induces pituitary tumor transforming gene expression in endocrine tumors. Endocr Relat Cancer. 2008 Sep; 15(3):817-31.
Zhou C, Tong Y, Wawrowsky K, Bannykh S, Donangelo I, Melmed S. PMID: 18550719; PMCID: PMC3123374.
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8 Fields:
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HumansCells
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Overexpression of human pituitary tumor transforming gene (hPTTG), is regulated by beta-catenin /TCF pathway in human esophageal squamous cell carcinoma. Int J Cancer. 2005 Mar 01; 113(6):891-8.
Zhou C, Liu S, Zhou X, Xue L, Quan L, Lu N, Zhang G, Bai J, Wang Y, Liu Z, Zhan Q, Zhu H, Xu N. PMID: 15514942.
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31 Fields:
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HumansCells