Clive N Svendsen

Title(s)Professor-in-Residence, Medicine
SchoolMedicine
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    A microphysiologic multicellular organ-on-chip to inform clinical trials in FTD/ALS
    NIH UG3TR003264Jul 1, 2020 - May 31, 2025
    Role: Co-Principal Investigator
    Multi-organ-on-chip device for modeling opioid reinforcement and withdrawal, and the negative affective component of pain: a therapeutic screening tool.
    NIH UG3TR003148Sep 26, 2019 - Jan 31, 2022
    Role: Co-Principal Investigator
    Development of a Microphysiological Organ-on-Chip System to Model Amyotrophic
    NIH UG3NS105703Sep 15, 2017 - Feb 28, 2023
    Role: Principal Investigator
    Development of a Microphysiological Organ-on-Chip System to Model Amyotrophic
    NIH UH3NS105703Sep 15, 2017 - Feb 28, 2023
    Role: Principal Investigator
    A genetic model of inflammatory bowel disease using human intestinal organoids.
    NIH R56DK106202Sep 5, 2015 - Aug 31, 2017
    Role: Co-Principal Investigator
    Neuron and Glial Cellular Signatures from Normal and Diseased iPS Cells
    NIH U54NS091046Sep 30, 2014 - Jun 30, 2021
    Role: Co-Principal Investigator
    Tracking cardiac engraftment and viability of MiPSC by MRI
    NIH R44EB019239Sep 1, 2014 - May 31, 2018
    Role: Co-Principal Investigator
    An iPS Disease-in-a-Dish Model of Familial Alzheimers
    NIH RF1AG042951Sep 1, 2012 - Aug 31, 2014
    Role: Co-Principal Investigator
    The Huntington's Disease iPS Consortium
    NIH RC2NS069422Sep 30, 2009 - Aug 31, 2012
    Role: Co-Principal Investigator
    Directing the Fate of Neural Stem Cells with Engineered Gradients of FGF-2
    NIH R21NS060047Apr 1, 2008 - Mar 31, 2010
    Role: Principal Investigator
    Stem Cell Therapy and Growth Factor Therapy for ALS
    NIH P01NS057778Sep 1, 2007 - Mar 31, 2012
    Role: Principal Investigator
    Stem Cell Research Training Program
    NIH T32AG027566May 1, 2005 - Jul 31, 2011
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lineage tracing: The gold standard to claim direct reprogramming in vivo. Mol Ther. 2022 03 02; 30(3):988-989. Svendsen CN, Sofroniew MV. PMID: 35123656; PMCID: PMC8899699.
      View in: PubMed   Mentions:
    2. Getting the upper hand in ALS. Gene Ther. 2022 Jan 20. Svendsen CN. PMID: 35046530.
      View in: PubMed   Mentions:
    3. Human iPSC-derived fallopian tube organoids with BRCA1 mutation recapitulate early-stage carcinogenesis. Cell Rep. 2021 12 28; 37(13):110146. Yucer N, Ahdoot R, Workman MJ, Laperle AH, Recouvreux MS, Kurowski K, Naboulsi DJ, Liang V, Qu Y, Plummer JT, Gayther SA, Orsulic S, Karlan BY, Svendsen CN. PMID: 34965417.
      View in: PubMed   Mentions:
    4. Microglial transcription profiles in mouse and human are driven by APOE4 and sex. iScience. 2021 Nov 19; 24(11):103238. Moser VA, Workman MJ, Hurwitz SJ, Lipman RM, Pike CJ, Svendsen CN. PMID: 34746703; PMCID: PMC8551075.
      View in: PubMed   Mentions:
    5. Antiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication. Cell Rep. 2021 04 06; 35(1):108940. Garcia G, Sharma A, Ramaiah A, Sen C, Purkayastha A, Kohn DB, Parcells MS, Beck S, Kim H, Bakowski MA, Kirkpatrick MG, Riva L, Wolff KC, Han B, Yuen C, Ulmert D, Purbey PK, Scumpia P, Beutler N, Rogers TF, Chatterjee AK, Gabriel G, Bartenschlager R, Gomperts B, Svendsen CN, Betz UAK, Damoiseaux RD, Arumugaswami V, Scumpia P. PMID: 33784499; PMCID: PMC7969873.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    6. Cross-Comparison of Human iPSC Motor Neuron Models of Familial and Sporadic ALS Reveals Early and Convergent Transcriptomic Disease Signatures. Cell Syst. 2021 02 17; 12(2):159-175.e9. Ho R, Workman MJ, Mathkar P, Wu K, Kim KJ, O'Rourke JG, Kellogg M, Montel V, Banuelos MG, Arogundade OA, Diaz-Garcia S, Oheb D, Huang S, Khrebtukova I, Watson L, Ravits J, Taylor K, Baloh RH, Svendsen CN. PMID: 33382996; PMCID: PMC7897311.
      View in: PubMed   Mentions: 2     Fields:    
    7. Modeling Intestinal Epithelial Response to Interferon-γ in Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids. Int J Mol Sci. 2020 Dec 30; 22(1). Workman MJ, Troisi E, Targan SR, Svendsen CN, Barrett RJ. PMID: 33396621; PMCID: PMC7794932.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    8. Novel nanopolymer RNA therapeutics normalize human diabetic corneal wound healing and epithelial stem cells. Nanomedicine. 2021 02; 32:102332. Kramerov AA, Shah R, Ding H, Holler E, Turjman S, Rabinowitz YS, Ghiam S, Maguen E, Svendsen CN, Saghizadeh M, Ljubimova JY, Ljubimov AV. PMID: 33181273; PMCID: PMC8107190.
      View in: PubMed   Mentions: 3     Fields:    
    9. Human iPSC-Derived Cardiomyocytes Are Susceptible to SARS-CoV-2 Infection. Cell Rep Med. 2020 07 21; 1(4):100052. Sharma A, Garcia G, Wang Y, Plummer JT, Morizono K, Arumugaswami V, Svendsen CN. PMID: 32835305; PMCID: PMC7323681.
      View in: PubMed   Mentions:
    10. Recent advances in human iPSC-derived models of the blood-brain barrier. Fluids Barriers CNS. 2020 Apr 22; 17(1):30. Workman MJ, Svendsen CN. PMID: 32321511; PMCID: PMC7178976.
      View in: PubMed   Mentions:
    11. Multi-lineage Human iPSC-Derived Platforms for Disease Modeling and Drug Discovery. Cell Stem Cell. 2020 03 05; 26(3):309-329. Sharma A, Sances S, Workman MJ, Svendsen CN. PMID: 32142662; PMCID: PMC7159985.
      View in: PubMed   Mentions:
    12. Development of Physiologically Responsive Human iPSC-Derived Intestinal Epithelium to Study Barrier Dysfunction in IBD. Int J Mol Sci. 2020 Feb 20; 21(4). Gleeson JP, Estrada HQ, Yamashita M, Svendsen CN, Targan SR, Barrett RJ. PMID: 32093254; PMCID: PMC7073090.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    13. Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support. Front Neurosci. 2019; 13:669. Garcia VJ, Rushton DJ, Tom CM, Allen ND, Kemp PJ, Svendsen CN, Mattis VB. PMID: 31316341; PMCID: PMC6610155.
      View in: PubMed   Mentions: 13  
    14. Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications. Cell Stem Cell. 2019 06 06; 24(6):995-1005.e6. Vatine GD, Barrile R, Workman MJ, Sances S, Barriga BK, Rahnama M, Barthakur S, Kasendra M, Lucchesi C, Kerns J, Wen N, Spivia WR, Chen Z, Van Eyk J, Svendsen CN. PMID: 31173718.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    15. In Vitro and In Vivo Proteomic Comparison of Human Neural Progenitor Cell-Induced Photoreceptor Survival. Proteomics. 2019 02; 19(3):e1800213. Jones MK, Lu B, Chen DZ, Spivia WR, Mercado AT, Ljubimov AV, Svendsen CN, Van Eyk JE, Wang S. PMID: 30515959; PMCID: PMC6422354.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    16. Inducible Expression of GDNF in Transplanted iPSC-Derived Neural Progenitor Cells. Stem Cell Reports. 2018 06 05; 10(6):1696-1704. Akhtar AA, Gowing G, Kobritz N, Savinoff SE, Garcia L, Saxon D, Cho N, Kim G, Tom CM, Park H, Lawless G, Shelley BC, Mattis VB, Breunig JJ, Svendsen CN. PMID: 29706501; PMCID: PMC5989694.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    17. Transplantation of Neural Progenitor Cells Expressing Glial Cell Line-Derived Neurotrophic Factor into the Motor Cortex as a Strategy to Treat Amyotrophic Lateral Sclerosis. Stem Cells. 2018 07; 36(7):1122-1131. Thomsen GM, Avalos P, Ma AA, Alkaslasi M, Cho N, Wyss L, Vit JP, Godoy M, Suezaki P, Shelest O, Bankiewicz KS, Svendsen CN. PMID: 29656478.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    18. Huntington modeling improves with age. Nat Neurosci. 2018 03; 21(3):301-303. Mattis VB, Svendsen CN. PMID: 29476127.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    19. Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips. Cell Mol Gastroenterol Hepatol. 2018; 5(4):669-677.e2. Workman MJ, Gleeson JP, Troisi EJ, Estrada HQ, Kerns SJ, Hinojosa CD, Hamilton GA, Targan SR, Svendsen CN, Barrett RJ. PMID: 29930984; PMCID: PMC6009013.
      View in: PubMed   Mentions: 47     Fields:    
    20. Directed Differentiation of Human Induced Pluripotent Stem Cells into Fallopian Tube Epithelium. Sci Rep. 2017 09 06; 7(1):10741. Yucer N, Holzapfel M, Jenkins Vogel T, Lenaeus L, Ornelas L, Laury A, Sareen D, Barrett R, Karlan BY, Svendsen CN. PMID: 28878359; PMCID: PMC5587694.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    21. Concise Review: Stem Cells for Corneal Wound Healing. Stem Cells. 2017 10; 35(10):2105-2114. Saghizadeh M, Kramerov AA, Svendsen CN, Ljubimov AV. PMID: 28748596; PMCID: PMC5637932.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    22. Patients with ALS show highly correlated progression rates in left and right limb muscles. Neurology. 2017 Jul 11; 89(2):196-206. Rushton DJ, Andres PL, Allred P, Baloh RH, Svendsen CN. PMID: 28600459; PMCID: PMC5501935.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    23. Modeling Psychomotor Retardation using iPSCs from MCT8-Deficient Patients Indicates a Prominent Role for the Blood-Brain Barrier. Cell Stem Cell. 2017 06 01; 20(6):831-843.e5. Vatine GD, Al-Ahmad A, Barriga BK, Svendsen S, Salim A, Garcia L, Garcia VJ, Ho R, Yucer N, Qian T, Lim RG, Wu J, Thompson LM, Spivia WR, Chen Z, Van Eyk J, Palecek SP, Refetoff S, Shusta EV, Svendsen CN. PMID: 28526555; PMCID: PMC6659720.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    24. Ex vivo gene therapy for the treatment of neurological disorders. Prog Brain Res. 2017; 230:99-132. Gowing G, Svendsen S, Svendsen CN. PMID: 28552237.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    25. A model of recurrent concussion that leads to long-term motor deficits, CTE-like tauopathy and exacerbation of an ALS phenotype. J Trauma Acute Care Surg. 2016 12; 81(6):1070-1079. Thomsen GM, Ma AM, Ko A, Harada MY, Wyss L, Haro PS, Vit JP, Shelest O, Rhee P, Svendsen CN, Ley EJ. PMID: 27602892.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    26. Transcriptome and proteome characterization of surface ectoderm cells differentiated from human iPSCs. Sci Rep. 2016 08 23; 6:32007. Qu Y, Zhou B, Yang W, Han B, Yu-Rice Y, Gao B, Johnson J, Svendsen CN, Freeman MR, Giuliano AE, Sareen D, Cui X. PMID: 27550649; PMCID: PMC4994084.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    27. ALS disrupts spinal motor neuron maturation and aging pathways within gene co-expression networks. Nat Neurosci. 2016 09; 19(9):1256-67. Ho R, Sances S, Gowing G, Amoroso MW, O'Rourke JG, Sahabian A, Wichterle H, Baloh RH, Sareen D, Svendsen CN. PMID: 27428653; PMCID: PMC5003654.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    28. Modeling ALS with motor neurons derived from human induced pluripotent stem cells. Nat Neurosci. 2016 Apr; 19(4):542-53. Sances S, Bruijn LI, Chandran S, Eggan K, Ho R, Klim JR, Livesey MR, Lowry E, Macklis JD, Rushton D, Sadegh C, Sareen D, Wichterle H, Zhang SC, Svendsen CN. PMID: 27021939; PMCID: PMC5015775.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    29. Human neural progenitors differentiate into astrocytes and protect motor neurons in aging rats. Exp Neurol. 2016 06; 280:41-9. Das MM, Avalos P, Suezaki P, Godoy M, Garcia L, Chang CD, Vit JP, Shelley B, Gowing G, Svendsen CN. PMID: 27032721.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    30. In Vivo CRISPR/Cas9 Gene Editing Corrects Retinal Dystrophy in the S334ter-3 Rat Model of Autosomal Dominant Retinitis Pigmentosa. Mol Ther. 2016 Mar; 24(3):556-63. Bakondi B, Lv W, Lu B, Jones MK, Tsai Y, Kim KJ, Levy R, Akhtar AA, Breunig JJ, Svendsen CN, Wang S. PMID: 26666451; PMCID: PMC4786918.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    31. Preclinical Validation of Multilevel Intraparenchymal Stem Cell Therapy in the Porcine Spinal Cord. Neurosurgery. 2015 Oct; 77(4):604-12; discussion 612. Gutierrez J, Lamanna JJ, Grin N, Hurtig CV, Miller JH, Riley J, Urquia L, Avalos P, Svendsen CN, Federici T, Boulis NM. PMID: 26134596.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    32. Low-Dose Irradiation Enhances Gene Targeting in Human Pluripotent Stem Cells. Stem Cells Transl Med. 2015 Sep; 4(9):998-1010. Hatada S, Subramanian A, Mandefro B, Ren S, Kim HW, Tang J, Funari V, Baloh RH, Sareen D, Arumugaswami V, Svendsen CN. PMID: 26185257; PMCID: PMC4542875.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    33. Acute Traumatic Brain Injury Does Not Exacerbate Amyotrophic Lateral Sclerosis in the SOD1 (G93A) Rat Model eNeuro. 2015 May-Jun; 2(3). Thomsen GM, Vit JP, Lamb A, Gowing G, Shelest O, Alkaslasi M, Ley EJ, Svendsen CN. PMID: 26464984; PMCID: PMC4586929.
      View in: PubMed   Mentions: 4     Fields:    
    34. Human iPSC-Derived Neural Progenitors Preserve Vision in an AMD-Like Model. Stem Cells. 2015 Aug; 33(8):2537-49. Tsai Y, Lu B, Bakondi B, Girman S, Sahabian A, Sareen D, Svendsen CN, Wang S. PMID: 25869002; PMCID: PMC5477659.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    35. A Subsequent Human Neural Progenitor Transplant into the Degenerate Retina Does Not Compromise Initial Graft Survival or Therapeutic Efficacy. Transl Vis Sci Technol. 2015 Feb; 4(1):7. Lu B, Lin Y, Tsai Y, Girman S, Adamus G, Jones MK, Shelley B, Svendsen CN, Wang S. PMID: 25694843; PMCID: PMC4324446.
      View in: PubMed   Mentions: 5  
    36. Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease. Sci Transl Med. 2014 Dec 24; 6(268):268ra178. Lu XH, Mattis VB, Wang N, Al-Ramahi I, van den Berg N, Fratantoni SA, Waldvogel H, Greiner E, Osmand A, Elzein K, Xiao J, Dijkstra S, de Pril R, Vinters HV, Faull R, Signer E, Kwak S, Marugan JJ, Botas J, Fischer DF, Svendsen CN, Munoz-Sanjuan I, Yang XW. PMID: 25540325.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    37. Delayed disease onset and extended survival in the SOD1G93A rat model of amyotrophic lateral sclerosis after suppression of mutant SOD1 in the motor cortex. J Neurosci. 2014 Nov 19; 34(47):15587-600. Thomsen GM, Gowing G, Latter J, Chen M, Vit JP, Staggenborg K, Avalos P, Alkaslasi M, Ferraiuolo L, Likhite S, Kaspar BK, Svendsen CN. PMID: 25411487; PMCID: PMC4298650.
      View in: PubMed   Mentions:
    38. Reliable generation of induced pluripotent stem cells from human lymphoblastoid cell lines. Stem Cells Transl Med. 2014 Dec; 3(12):1429-34. Barrett R, Ornelas L, Yeager N, Mandefro B, Sahabian A, Lenaeus L, Targan SR, Svendsen CN, Sareen D. PMID: 25298370; PMCID: PMC4250214.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    39. Astrocytes show reduced support of motor neurons with aging that is accelerated in a rodent model of ALS. Neurobiol Aging. 2015 Feb; 36(2):1130-9. Das MM, Svendsen CN. PMID: 25443290.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    40. Differentiation of human limbal-derived induced pluripotent stem cells into limbal-like epithelium. Stem Cells Transl Med. 2014 Sep; 3(9):1002-12. Sareen D, Saghizadeh M, Ornelas L, Winkler MA, Narwani K, Sahabian A, Funari VA, Tang J, Spurka L, Punj V, Maguen E, Rabinowitz YS, Svendsen CN, Ljubimov AV. PMID: 25069777; PMCID: PMC4149305.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    41. A cGMP-applicable expansion method for aggregates of human neural stem and progenitor cells derived from pluripotent stem cells or fetal brain tissue. J Vis Exp. 2014 Jun 15; (88). Shelley BC, Gowing G, Svendsen CN. PMID: 24962813; PMCID: PMC4195512.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    42. Glial cell line-derived neurotrophic factor-secreting human neural progenitors show long-term survival, maturation into astrocytes, and no tumor formation following transplantation into the spinal cord of immunocompromised rats. Neuroreport. 2014 Apr 16; 25(6):367-72. Gowing G, Shelley B, Staggenborg K, Hurley A, Avalos P, Victoroff J, Latter J, Garcia L, Svendsen CN. PMID: 24284956; PMCID: PMC3969154.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    43. Human induced pluripotent stem cells are a novel source of neural progenitor cells (iNPCs) that migrate and integrate in the rodent spinal cord. J Comp Neurol. 2014 Aug 15; 522(12):2707-28. Sareen D, Gowing G, Sahabian A, Staggenborg K, Paradis R, Avalos P, Latter J, Ornelas L, Garcia L, Svendsen CN. PMID: 24610630; PMCID: PMC4070510.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    44. Patient-derived skeletal dysplasia induced pluripotent stem cells display abnormal chondrogenic marker expression and regulation by BMP2 and TGFβ1. Stem Cells Dev. 2014 Jul 01; 23(13):1464-78. Saitta B, Passarini J, Sareen D, Ornelas L, Sahabian A, Argade S, Krakow D, Cohn DH, Svendsen CN, Rimoin DL. PMID: 24559391; PMCID: PMC4066255.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    45. The past, present and future of stem cell clinical trials for ALS. Exp Neurol. 2014 Dec; 262 Pt B:127-37. Thomsen GM, Gowing G, Svendsen S, Svendsen CN. PMID: 24613827.
      View in: PubMed   Mentions:
    46. Sca1⁺ murine pituitary adenoma cells show tumor-growth advantage. Endocr Relat Cancer. 2014 Apr; 21(2):203-16. Donangelo I, Ren SG, Eigler T, Svendsen C, Melmed S. PMID: 24481638; PMCID: PMC3978815.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    47. Ocular changes in TgF344-AD rat model of Alzheimer's disease. Invest Ophthalmol Vis Sci. 2014 Jan 29; 55(1):523-34. Tsai Y, Lu B, Ljubimov AV, Girman S, Ross-Cisneros FN, Sadun AA, Svendsen CN, Cohen RM, Wang S. PMID: 24398104; PMCID: PMC3907137.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimals
    48. Neonatal immune-tolerance in mice does not prevent xenograft rejection. Exp Neurol. 2014 Apr; 254:90-8. Mattis VB, Wakeman DR, Tom C, Dodiya HB, Yeung SY, Tran AH, Bernau K, Ornelas L, Sahabian A, Reidling J, Sareen D, Thompson LM, Kordower JH, Svendsen CN. PMID: 24440640; PMCID: PMC3954854.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    49. A simple alkaline method for decellularizing human amniotic membrane for cell culture. PLoS One. 2013; 8(11):e79632. Saghizadeh M, Winkler MA, Kramerov AA, Hemmati DM, Ghiam CA, Dimitrijevich SD, Sareen D, Ornelas L, Ghiasi H, Brunken WJ, Maguen E, Rabinowitz YS, Svendsen CN, Jirsova K, Ljubimov AV. PMID: 24236148; PMCID: PMC3827346.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    50. Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion. Sci Transl Med. 2013 Oct 23; 5(208):208ra149. Sareen D, O'Rourke JG, Meera P, Muhammad AK, Grant S, Simpkinson M, Bell S, Carmona S, Ornelas L, Sahabian A, Gendron T, Petrucelli L, Baughn M, Ravits J, Harms MB, Rigo F, Bennett CF, Otis TS, Svendsen CN, Baloh RH. PMID: 24154603; PMCID: PMC4090945.
      View in: PubMed   Mentions: 303     Fields:    Translation:HumansCells
    51. Synergistic effects of GDNF and VEGF on lifespan and disease progression in a familial ALS rat model. Mol Ther. 2013 Aug; 21(8):1602-10. Krakora D, Mulcrone P, Meyer M, Lewis C, Bernau K, Gowing G, Zimprich C, Aebischer P, Svendsen CN, Suzuki M. PMID: 23712039; PMCID: PMC3734670.
      View in: PubMed   Mentions:
    52. Neural Stem Cells Derived by Small Molecules Preserve Vision. Transl Vis Sci Technol. 2013 Jan; 2(1):1. Lu B, Morgans CW, Girman S, Luo J, Zhao J, Du H, Lim S, Ding S, Svendsen C, Zhang K, Wang S. PMID: 24049711; PMCID: PMC3763886.
      View in: PubMed   Mentions: 9  
    53. The in vitro survival of human monosomies and trisomies as embryonic stem cells. Stem Cell Res. 2012 Nov; 9(3):218-24. Biancotti JC, Narwani K, Mandefro B, Golan-Lev T, Buehler N, Hill D, Svendsen CN, Benvenisty N. PMID: 22892439.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    54. Rapid genetic targeting of pial surface neural progenitors and immature neurons by neonatal electroporation. Neural Dev. 2012 Jul 10; 7:26. Breunig JJ, Gate D, Levy R, Rodriguez J, Kim GB, Danielpour M, Svendsen CN, Town T. PMID: 22776033; PMCID: PMC3479020.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    55. Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy. PLoS One. 2012; 7(6):e39113. Sareen D, Ebert AD, Heins BM, McGivern JV, Ornelas L, Svendsen CN. PMID: 22723941; PMCID: PMC3378532.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCells
    56. Stem cell transplantation for motor neuron disease: current approaches and future perspectives. Neurotherapeutics. 2011 Oct; 8(4):591-606. Gowing G, Svendsen CN. PMID: 21904789; PMCID: PMC3210365.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    57. Gene editing in stem cells hits the target. Cell Stem Cell. 2011 Aug 05; 9(2):93-4. Kim HW, Svendsen CN. PMID: 21816359.
      View in: PubMed   Mentions: 3     Fields:    
    58. Induced pluripotent stem cells: a new revolution for clinical neurology? Lancet Neurol. 2011 Apr; 10(4):383-94. Mattis VB, Svendsen CN. PMID: 21435601.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    59. Gene therapy-mediated delivery of targeted cytotoxins for glioma therapeutics. Proc Natl Acad Sci U S A. 2010 Nov 16; 107(46):20021-6. Candolfi M, Xiong W, Yagiz K, Liu C, Muhammad AK, Puntel M, Foulad D, Zadmehr A, Ahlzadeh GE, Kroeger KM, Tesarfreund M, Lee S, Debinski W, Sareen D, Svendsen CN, Rodriguez R, Lowenstein PR, Castro MG. PMID: 21030678; PMCID: PMC2993419.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    60. Stem cell biologists sure play a mean pinball. Nat Biotechnol. 2010 Apr; 28(4):333-5. Sareen D, Svendsen CN. PMID: 20379177; PMCID: PMC3142542.
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