Clive N Svendsen

Title(s)Professor-in-Residence, Medicine
SchoolMedicine
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    A microphysiologic multicellular organ-on-chip to inform clinical trials in FTD/ALS
    NIH UG3TR003264Jul 1, 2020 - May 31, 2025
    Role: Co-Principal Investigator
    Multi-organ-on-chip device for modeling opioid reinforcement and withdrawal, and the negative affective component of pain: a therapeutic screening tool.
    NIH UG3TR003148Sep 26, 2019 - Jan 31, 2022
    Role: Co-Principal Investigator
    Development of a Microphysiological Organ-on-Chip System to Model Amyotrophic
    NIH UG3NS105703Sep 15, 2017 - Feb 28, 2023
    Role: Principal Investigator
    Development of a Microphysiological Organ-on-Chip System to Model Amyotrophic
    NIH UH3NS105703Sep 15, 2017 - Feb 28, 2023
    Role: Principal Investigator
    A genetic model of inflammatory bowel disease using human intestinal organoids.
    NIH R56DK106202Sep 5, 2015 - Aug 31, 2017
    Role: Co-Principal Investigator
    Neuron and Glial Cellular Signatures from Normal and Diseased iPS Cells
    NIH U54NS091046Sep 30, 2014 - Jun 30, 2021
    Role: Co-Principal Investigator
    Tracking cardiac engraftment and viability of MiPSC by MRI
    NIH R44EB019239Sep 1, 2014 - May 31, 2018
    Role: Co-Principal Investigator
    An iPS Disease-in-a-Dish Model of Familial Alzheimers
    NIH RF1AG042951Sep 1, 2012 - Aug 31, 2014
    Role: Co-Principal Investigator
    The Huntington's Disease iPS Consortium
    NIH RC2NS069422Sep 30, 2009 - Aug 31, 2012
    Role: Co-Principal Investigator
    Directing the Fate of Neural Stem Cells with Engineered Gradients of FGF-2
    NIH R21NS060047Apr 1, 2008 - Mar 31, 2010
    Role: Principal Investigator
    Stem Cell Therapy and Growth Factor Therapy for ALS
    NIH P01NS057778Sep 1, 2007 - Mar 31, 2012
    Role: Principal Investigator
    Stem Cell Research Training Program
    NIH T32AG027566May 1, 2005 - Jul 31, 2011
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Adopting novel alternative methods (NAMs) for biomedical research-What is the right approach? Cell Stem Cell. 2025 Aug 29. Svendsen CN. PMID: 40914156.
      View in: PubMed   Mentions:
    2. Human iPSC-Derived Mononuclear Phagocytes Improve Cognition and Neural Health across Multiple Mouse Models of Aging and Alzheimer's Disease. Adv Sci (Weinh). 2025 Aug 24; e17848. Moser VA, Dimas-Harms LJ, Lipman RM, Inzalaco J, Bell S, Alcantara M, Valenzuela E, Lawless G, Kreimer S, Parker SJ, Goodridge HS, Svendsen CN. PMID: 40850934.
      View in: PubMed   Mentions:
    3. Corrigendum to "Comprehensive Proteomics Metadata and Integrative Web Portals Facilitate Sharing and Integration of LINCS Multiomics Data". Mol Cell Proteomics. 2025 Jul; 24(7):100995. Vidovic D, Shamsaei B, Schürer SC, Kogan P, Chojnacki S, Kouril M, Medvedovic M, Niu W, Azeloglu EU, Birtwistle MR, Chen Y, Chen T, Hansen J, Hu B, Iyengar R, Jayaraman G, Li H, Liu T, Sobie EA, Xiong Y, Berberich MJ, Bradshaw G, Chung M, Everley RA, Gaudio B, Hafner M, Kalocsay M, Mills CE, Nariya MK, Sorger PK, Subramanian K, Victor C, Banuelos M, Dardov V, Holewinski R, Manalo DM, Mandefro B, Matlock AD, Ornelas L, Sareen D, Svendsen CN, Vaibhav V, Van Eyk JE, Venkatraman V, Finkbiener S, Fraenkel E, Rothstein J, Thompson L, Asiedu J, Carr SA, Christianson KE, Davison D, Dele-Oni DO, DeRuff KC, Egri SB, Vaca Jacome AS, Jaffe JD, Lam D, Litichevskiy L, Lu X, Mullahoo J, Officer A, Papanastasiou M, Peckner R, Toder C, Blanchard J, Bula M, Ko T, Tsai LH, Young JZ, Sharma V, Meller J, MacCoss MJ. PMID: 40783300; PMCID: PMC12365493.
      View in: PubMed   Mentions:
    4. An organ-chip model of sporadic ALS using iPSC-derived spinal cord motor neurons and an integrated blood-brain-like barrier. Cell Stem Cell. 2025 Jul 03; 32(7):1139-1153.e7. Lall D, Workman MJ, Sances S, Ondatje BN, Bell S, Lawless G, Woodbury A, West D, Meyer A, Matlock A, Vaibhav V, Van Eyk JE, Svendsen CN. PMID: 40562033; PMCID: PMC12233189.
      View in: PubMed   Mentions:
    5. Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects. Neuron. 2025 May 28. Workman MJ, Lim RG, Wu J, Frank A, Ornelas L, Panther L, Galvez E, Perez D, Meepe I, Lei S, Valencia V, Gomez E, Liu C, Moran R, Pinedo L, Tsitkov S, Ho R, Kaye JA, Answer ALS Consortium, Thompson T, Rothstein JD, Finkbeiner S, Fraenkel E, Sareen D, Thompson LM, Svendsen CN. PMID: 40441139.
      View in: PubMed   Mentions:    Fields:    
    6. Comprehensive Proteomics Metadata and Integrative Web Portals Facilitate Sharing and Integration of LINCS Multiomics Data. Mol Cell Proteomics. 2025 Jul; 24(7):100947. Vidovic D, Shamsaei B, Schürer SC, Kogan P, Chojnacki S, Kouril M, Medvedovic M, Niu W, Azeloglu EU, Birtwistle MR, Chen Y, Chen T, Hansen J, Hu B, Iyengar R, Jayaraman G, Li H, Liu T, Sobie EA, Xiong Y, Berberich MJ, Bradshaw G, Chung M, Everley RA, Gaudio B, Hafner M, Kalocsay M, Mills CE, Nariya MK, Sorger PK, Subramanian K, Victor C, Banuelos M, Dardov V, Holewinski R, Manalo DM, Mandefro B, Matlock AD, Ornelas L, Sareen D, Svendsen CN, Vaibhav V, Van Eyk JE, Venkatraman V, Finkbiener S, Fraenkel E, Rothstein J, Thompson L, Asiedu J, Carr SA, Christianson KE, Davison D, Dele-Oni DO, DeRuff KC, Egri SB, Jacome ASV, Jaffe JD, Lam D, Litichevskiy L, Lu X, Mullahoo J, Officer A, Papanastasiou M, Peckner R, Toder C, Blanchard J, Bula M, Ko T, Tsai LH, Young JZ, Sharma V, Pillai A, Meller J, MacCoss MJ. PMID: 40089066; PMCID: PMC12332945.
      View in: PubMed   Mentions:    Fields:    
    7. Systemic HER3 ligand-mimicking nanobioparticles enter the brain and reduce intracranial tumour growth. Nat Nanotechnol. 2025 May; 20(5):683-696. Alonso-Valenteen F, Mikhael S, Wang H, Sims J, Taguiam M, Teh J, Sances S, Wong M, Miao T, Srinivas D, Gonzalez-Almeyda N, Cho RH, Sanchez R, Nguyenle K, Serrano E, Ondatje B, Benhaghnazar RL, Gray HB, Gross Z, Yu J, Svendsen CN, Abrol R, Medina-Kauwe LK. PMID: 39984637; PMCID: PMC12095042.
      View in: PubMed   Mentions: 3     Fields:    
    8. Single Cell Proteomics Reveals Specific Cellular Subtypes in Cardiomyocytes Derived from Human iPSCs and Adult Hearts. Mol Cell Proteomics. 2025 Jan 22; 100910. Ai L, Binek A, Zhemkov V, Cho JH, Haghani A, Kreimer S, Israely E, Arzt M, Chazarin B, Sundararaman N, Sharma A, Marbán E, Svendsen CN, Van Eyk JE. PMID: 39855627.
      View in: PubMed   Mentions:    Fields:    
    9. Neurotrophic factors for Parkinson's disease: Current status, progress, and remaining questions. Conclusions from a 2023 workshop. J Parkinsons Dis. 2024 Nov; 14(8):1659-1676. Barker RA, Saarma M, Svendsen CN, Morgan C, Whone A, Fiandaca MS, Luz M, Bankiewicz KS, Fiske B, Isaacs L, Roach A, Phipps T, Kordower JH, Lane EL, Huttunen HJ, Sullivan A, O'Keeffe G, Yartseva V, Federoff H. PMID: 39957193.
      View in: PubMed   Mentions:    Fields:    
    10. Longitudinal Quantitative MRI Provides Responsive Outcome Measures for Early and Late Muscle Changes in ALS. Muscle Nerve. 2025 Feb; 71(2):171-182. Diaz F, Thornton JS, Wastling SS, Asaab A, Morrow JM, Zafeiropoulos N, Bresee C, Allred P, Avalos P, Lewis RA, Baloh RH, Svendsen CN. PMID: 39611310.
      View in: PubMed   Mentions: 1     Fields:    
    11. Surface tension enables induced pluripotent stem cell culture in commercially available hardware during spaceflight. NPJ Microgravity. 2024 Oct 15; 10(1):97. Mozneb M, Arzt M, Mesci P, Martin DMN, Pohlman S, Lawless G, Doraisingam S, Al Neyadi S, Barnawi R, Al Qarni A, Whitson PA, Shoffner J, Stoudemire J, Countryman S, Svendsen CN, Sharma A. PMID: 39402072; PMCID: PMC11473755.
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    12. Cell therapy for neurological disorders. Nat Med. 2024 Oct; 30(10):2756-2770. Svendsen SP, Svendsen CN. PMID: 39407034.
      View in: PubMed   Mentions: 7     Fields:    
    13. Disease related changes in ATAC-seq of iPSC-derived motor neuron lines from ALS patients and controls. Nat Commun. 2024 May 02; 15(1):3606. Tsitkov S, Valentine K, Kozareva V, Donde A, Frank A, Lei S, Answer ALS Consortium, E Van Eyk J, Finkbeiner S, Rothstein JD, Thompson LM, Sareen D, Svendsen CN, Fraenkel E. PMID: 38697975; PMCID: PMC11066062.
      View in: PubMed   Mentions: 1     Fields:    
    14. Survival of the fittest glia. Nat Biotechnol. 2024 May; 42(5):700-702. Moser VA, Svendsen CN. PMID: 37640947.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    15. SOX9 switch links regeneration to fibrosis at the single-cell level in mammalian kidneys. Science. 2024 02 23; 383(6685):eadd6371. Aggarwal S, Wang Z, Rincon Fernandez Pacheco D, Rinaldi A, Rajewski A, Callemeyn J, Van Loon E, Lamarthée B, Covarrubias AE, Hou J, Yamashita M, Akiyama H, Karumanchi SA, Svendsen CN, Noble PW, Jordan SC, Breunig JJ, Naesens M, Cippà PE, Kumar S. PMID: 38386758; PMCID: PMC11345873.
      View in: PubMed   Mentions: 19     Fields:    
    16. Multi-lineage heart-chip models drug cardiotoxicity and enhances maturation of human stem cell-derived cardiovascular cells. Lab Chip. 2024 02 13; 24(4):869-881. Mozneb M, Jenkins A, Sances S, Pohlman S, Workman MJ, West D, Ondatje B, El-Ghazawi K, Woodbury A, Garcia VJ, Patel S, Arzt M, Dezem F, Laperle AH, Moser VA, Ho R, Yucer N, Plummer J, Barrett RJ, Svendsen CN, Sharma A. PMID: 38252454; PMCID: PMC12015978.
      View in: PubMed   Mentions: 5     Fields:    
    17. Human Neural Progenitors Expressing GDNF Enhance Retinal Protection in a Rodent Model of Retinal Degeneration. Stem Cells Transl Med. 2023 Nov 03; 12(11):727-744. Shahin S, Tan P, Chetsawang J, Lu B, Svendsen S, Ramirez S, Conniff T, Alfaro JS, Fernandez M, Fulton A, Laperle AH, Svendsen CN, Wang S. PMID: 37786347; PMCID: PMC10630082.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    18. Roadmap for C9ORF72 in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis: Report on the C9ORF72 FTD/ALS Summit. Neurol Ther. 2023 Dec; 12(6):1821-1843. Sattler R, Traynor BJ, Robertson J, Van Den Bosch L, Barmada SJ, Svendsen CN, Disney MD, Gendron TF, Wong PC, Turner MR, Boxer A, Babu S, Benatar M, Kurnellas M, Rohrer JD, Donnelly CJ, Bustos LM, Van Keuren-Jensen K, Dacks PA, Sabbagh MN, Attendees of the inaugural C9ORF72 FTD/ALS Summit. PMID: 37847372; PMCID: PMC10630271.
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    19. GMP-grade human neural progenitors delivered subretinally protect vision in rat model of retinal degeneration and survive in minipigs. J Transl Med. 2023 09 25; 21(1):650. Lu B, Avalos P, Svendsen S, Zhang C, Nocito L, Jones MK, Pieplow C, Saylor J, Ghiam S, Block A, Fernandez M, Ljubimov AV, Small K, Liao D, Svendsen CN, Wang S. PMID: 37743503; PMCID: PMC10519102.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    20. Organ-Chips Enhance the Maturation of Human iPSC-Derived Dopamine Neurons. Int J Mol Sci. 2023 Sep 18; 24(18). Otero MG, Bell S, Laperle AH, Lawless G, Myers Z, Castro MA, Villalba JM, Svendsen CN. PMID: 37762529; PMCID: PMC10531789.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    21. Translational roadmap for regenerative therapies of eye disease. Med. 2023 09 08; 4(9):583-590. Levin LA, Chiang MF, Dyer MA, Greenwell TN, Svendsen CN, Tumminia SJ, Van Gelder RN, Wong RO. PMID: 37689055; PMCID: PMC10793077.
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    22. Reversal of dual epigenetic repression of non-canonical Wnt-5a normalises diabetic corneal epithelial wound healing and stem cells. Diabetologia. 2023 10; 66(10):1943-1958. Shah R, Spektor TM, Weisenberger DJ, Ding H, Patil R, Amador C, Song XY, Chun ST, Inzalaco J, Turjman S, Ghiam S, Jeong-Kim J, Tolstoff S, Yampolsky SV, Sawant OB, Rabinowitz YS, Maguen E, Hamrah P, Svendsen CN, Saghizadeh M, Ljubimova JY, Kramerov AA, Ljubimov AV. PMID: 37460827; PMCID: PMC10474199.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    23. Human iPSC-derived neural progenitor cells secreting GDNF provide protection in rodent models of ALS and retinal degeneration. Stem Cell Reports. 2023 08 08; 18(8):1629-1642. Laperle AH, Moser VA, Avalos P, Lu B, Wu A, Fulton A, Ramirez S, Garcia VJ, Bell S, Ho R, Lawless G, Roxas K, Shahin S, Shelest O, Svendsen S, Wang S, Svendsen CN. PMID: 37084724; PMCID: PMC10444557.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    24. Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects. Neuron. 2023 04 19; 111(8):1191-1204.e5. Workman MJ, Lim RG, Wu J, Frank A, Ornelas L, Panther L, Galvez E, Perez D, Meepe I, Lei S, Valencia V, Gomez E, Liu C, Moran R, Pinedo L, Tsitkov S, Ho R, Kaye JA, Answer ALS Consortium, Thompson T, Rothstein JD, Finkbeiner S, Fraenkel E, Sareen D, Thompson LM, Svendsen CN. PMID: 36764301; PMCID: PMC10557526.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    25. NeuroLINCS Proteomics: Defining human-derived iPSC proteomes and protein signatures of pluripotency. Sci Data. 2023 01 11; 10(1):24. Matlock AD, Vaibhav V, Holewinski R, Venkatraman V, Dardov V, Manalo DM, Shelley B, Ornelas L, Banuelos M, Mandefro B, Escalante-Chong R, Li J, Finkbeiner S, Fraenkel E, Rothstein J, Thompson L, Sareen D, Svendsen CN, NIH NeuroLINCS Consortium, Van Eyk JE. PMID: 36631473; PMCID: PMC9834231.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    26. Tissue clearing of human iPSC-derived organ-chips enables high resolution imaging and analysis. Lab Chip. 2022 Oct 25; 22(21):4246-4255. Ondatje BN, Sances S, Workman MJ, Svendsen CN. PMID: 36205191; PMCID: PMC9595176.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    27. Author Correction: Regenerative and restorative medicine for eye disease. Nat Med. 2022 Oct; 28(10):2218. Van Gelder RN, Chiang MF, Dyer MA, Greenwell TN, Levin LA, Wong RO, Svendsen CN. PMID: 35945286; PMCID: PMC12331158.
      View in: PubMed   Mentions:
    28. Transplantation of human neural progenitor cells secreting GDNF into the spinal cord of patients with ALS: a phase 1/2a trial. Nat Med. 2022 09; 28(9):1813-1822. Baloh RH, Johnson JP, Avalos P, Allred P, Svendsen S, Gowing G, Roxas K, Wu A, Donahue B, Osborne S, Lawless G, Shelley B, Wheeler K, Prina C, Fine D, Kendra-Romito T, Stokes H, Manoukian V, Muthukumaran A, Garcia L, Bañuelos MG, Godoy M, Bresee C, Yu H, Drazin D, Ross L, Naruse R, Babu H, Macklin EA, Vo A, Elsayegh A, Tourtellotte W, Maya M, Burford M, Diaz F, Patil CG, Lewis RA, Svendsen CN. PMID: 36064599; PMCID: PMC9499868.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    29. Regenerative and restorative medicine for eye disease. Nat Med. 2022 06; 28(6):1149-1156. Van Gelder RN, Chiang MF, Dyer MA, Greenwell TN, Levin LA, Wong RO, Svendsen CN. PMID: 35715505; PMCID: PMC10718186.
      View in: PubMed   Mentions:
    30. AAV9-MCT8 Delivery at Juvenile Stage Ameliorates Neurological and Behavioral Deficits in a Mouse Model of MCT8-Deficiency. Thyroid. 2022 07; 32(7):849-859. Liao XH, Avalos P, Shelest O, Ofan R, Shilo M, Bresee C, Likhite S, Vit JP, Heuer H, Kaspar B, Meyer K, Dumitrescu AM, Refetoff S, Svendsen CN, Vatine GD. PMID: 35350867; PMCID: PMC9469747.
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    31. Sodium Phenylbutyrate Rescues Thyroid Hormone Transport in Brain Endothelial-Like Cells. Thyroid. 2022 07; 32(7):860-870. Braun D, Bohleber S, Vatine GD, Svendsen CN, Schweizer U. PMID: 35357974.
      View in: PubMed   Mentions:
    32. Lineage tracing: The gold standard to claim direct reprogramming in vivo. Mol Ther. 2022 03 02; 30(3):988-989. Svendsen CN, Sofroniew MV. PMID: 35123656; PMCID: PMC8899699.
      View in: PubMed   Mentions: 6     Fields:    
    33. Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines. Nat Neurosci. 2022 02; 25(2):226-237. Baxi EG, Thompson T, Li J, Kaye JA, Lim RG, Wu J, Ramamoorthy D, Lima L, Vaibhav V, Matlock A, Frank A, Coyne AN, Landin B, Ornelas L, Mosmiller E, Thrower S, Farr SM, Panther L, Gomez E, Galvez E, Perez D, Meepe I, Lei S, Mandefro B, Trost H, Pinedo L, Banuelos MG, Liu C, Moran R, Garcia V, Workman M, Ho R, Wyman S, Roggenbuck J, Harms MB, Stocksdale J, Miramontes R, Wang K, Venkatraman V, Holewenski R, Sundararaman N, Pandey R, Manalo DM, Donde A, Huynh N, Adam M, Wassie BT, Vertudes E, Amirani N, Raja K, Thomas R, Hayes L, Lenail A, Cerezo A, Luppino S, Farrar A, Pothier L, Prina C, Morgan T, Jamil A, Heintzman S, Jockel-Balsarotti J, Karanja E, Markway J, McCallum M, Joslin B, Alibazoglu D, Kolb S, Ajroud-Driss S, Baloh R, Heitzman D, Miller T, Glass JD, Patel-Murray NL, Yu H, Sinani E, Vigneswaran P, Sherman AV, Ahmad O, Roy P, Beavers JC, Zeiler S, Krakauer JW, Agurto C, Cecchi G, Bellard M, Raghav Y, Sachs K, Ehrenberger T, Bruce E, Cudkowicz ME, Maragakis N, Norel R, Van Eyk JE, Finkbeiner S, Berry J, Sareen D, Thompson LM, Fraenkel E, Svendsen CN, Rothstein JD. PMID: 35115730; PMCID: PMC8825283.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    34. Getting the upper hand in ALS. Gene Ther. 2022 04; 29(3-4):113-114. Svendsen CN. PMID: 35046530; PMCID: PMC9013663.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    35. The proSAAS Chaperone Provides Neuroprotection and Attenuates Transsynaptic α-Synuclein Spread in Rodent Models of Parkinson's Disease. J Parkinsons Dis. 2022; 12(5):1463-1478. Lindberg I, Shu Z, Lam H, Helwig M, Yucer N, Laperle A, Svendsen CN, Di Monte DA, Maidment NT. PMID: 35527562; PMCID: PMC9731515.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    36. Human iPSC-derived fallopian tube organoids with BRCA1 mutation recapitulate early-stage carcinogenesis. Cell Rep. 2021 12 28; 37(13):110146. Yucer N, Ahdoot R, Workman MJ, Laperle AH, Recouvreux MS, Kurowski K, Naboulsi DJ, Liang V, Qu Y, Plummer JT, Gayther SA, Orsulic S, Karlan BY, Svendsen CN. PMID: 34965417; PMCID: PMC9000920.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    37. Emerging technologies and their impact on regulatory science. Exp Biol Med (Maywood). 2022 01; 247(1):1-75. Anklam E, Bahl MI, Ball R, Beger RD, Cohen J, Fitzpatrick S, Girard P, Halamoda-Kenzaoui B, Hinton D, Hirose A, Hoeveler A, Honma M, Hugas M, Ishida S, Kass GE, Kojima H, Krefting I, Liachenko S, Liu Y, Masters S, Marx U, McCarthy T, Mercer T, Patri A, Pelaez C, Pirmohamed M, Platz S, Ribeiro AJ, Rodricks JV, Rusyn I, Salek RM, Schoonjans R, Silva P, Svendsen CN, Sumner S, Sung K, Tagle D, Tong L, Tong W, Eijnden-van-Raaij JVD, Vary N, Wang T, Waterton J, Wang M, Wen H, Wishart D, Yuan Y, Slikker W. PMID: 34783606; PMCID: PMC8749227.
      View in: PubMed   Mentions:
    38. An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients. iScience. 2021 Nov 19; 24(11):103221. NeuroLINCS Consortium, Li J, Lim RG, Kaye JA, Dardov V, Coyne AN, Wu J, Milani P, Cheng A, Thompson TG, Ornelas L, Frank A, Adam M, Banuelos MG, Casale M, Cox V, Escalante-Chong R, Daigle JG, Gomez E, Hayes L, Holewenski R, Lei S, Lenail A, Lima L, Mandefro B, Matlock A, Panther L, Patel-Murray NL, Pham J, Ramamoorthy D, Sachs K, Shelley B, Stocksdale J, Trost H, Wilhelm M, Venkatraman V, Wassie BT, Wyman S, Yang S, NYGC ALS Consortium, Van Eyk JE, Lloyd TE, Finkbeiner S, Fraenkel E, Rothstein JD, Sareen D, Svendsen CN, Thompson LM. PMID: 34746695; PMCID: PMC8554488.
      View in: PubMed   Mentions: 22  
    39. Microglial transcription profiles in mouse and human are driven by APOE4 and sex. iScience. 2021 Nov 19; 24(11):103238. Moser VA, Workman MJ, Hurwitz SJ, Lipman RM, Pike CJ, Svendsen CN. PMID: 34746703; PMCID: PMC8551075.
      View in: PubMed   Mentions: 11  
    40. Oligodendrocyte progenitor cell maturation is dependent on dual function of MCT8 in the transport of thyroid hormone across brain barriers and the plasma membrane. Glia. 2021 09; 69(9):2146-2159. Vatine GD, Shelest O, Barriga BK, Ofan R, Rabinski T, Mattis VB, Heuer H, Svendsen CN. PMID: 33956384.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    41. Antiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication. Cell Rep. 2021 04 06; 35(1):108940. Garcia G, Sharma A, Ramaiah A, Sen C, Purkayastha A, Kohn DB, Parcells MS, Beck S, Kim H, Bakowski MA, Kirkpatrick MG, Riva L, Wolff KC, Han B, Yuen C, Ulmert D, Purbey PK, Scumpia P, Beutler N, Rogers TF, Chatterjee AK, Gabriel G, Bartenschlager R, Gomperts B, Svendsen CN, Betz UAK, Damoiseaux RD, Arumugaswami V. PMID: 33784499; PMCID: PMC7969873.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    42. Stem Cell-Derived Dopamine Neurons: Will They Replace DBS as the Leading Neurosurgical Treatment for Parkinson's Disease? J Parkinsons Dis. 2021; 11(3):909-917. Barker RA, Björklund A, Frucht SJ, Svendsen CN. PMID: 34334425.
      View in: PubMed   Mentions:
    43. Modeling Intestinal Epithelial Response to Interferon-γ in Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids. Int J Mol Sci. 2020 Dec 30; 22(1). Workman MJ, Troisi E, Targan SR, Svendsen CN, Barrett RJ. PMID: 33396621; PMCID: PMC7794932.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
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    95. In Vivo Tracking of Human Neural Progenitor Cells in the Rat Brain Using Magnetic Resonance Imaging Is Not Enhanced by Ferritin Expression. Cell Transplant. 2016; 25(3):575-92. Bernau K, Lewis CM, Petelinsek AM, Reagan MS, Niles DJ, Mattis VB, Meyerand ME, Suzuki M, Svendsen CN. PMID: 26160767; PMCID: PMC5052815.
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    96. Acute Traumatic Brain Injury Does Not Exacerbate Amyotrophic Lateral Sclerosis in the SOD1 (G93A) Rat Model eNeuro. 2015 May-Jun; 2(3). Thomsen GM, Vit JP, Lamb A, Gowing G, Shelest O, Alkaslasi M, Ley EJ, Svendsen CN. PMID: 26464984; PMCID: PMC4586929.
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    97. Human iPSC-Derived Neural Progenitors Preserve Vision in an AMD-Like Model. Stem Cells. 2015 Aug; 33(8):2537-49. Tsai Y, Lu B, Bakondi B, Girman S, Sahabian A, Sareen D, Svendsen CN, Wang S. PMID: 25869002; PMCID: PMC5477659.
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    98. HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity. Hum Mol Genet. 2015 Jun 01; 24(11):3257-71. Mattis VB, Tom C, Akimov S, Saeedian J, Østergaard ME, Southwell AL, Doty CN, Ornelas L, Sahabian A, Lenaeus L, Mandefro B, Sareen D, Arjomand J, Hayden MR, Ross CA, Svendsen CN. PMID: 25740845; PMCID: PMC4424959.
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    99. Kuwanon V inhibits proliferation, promotes cell survival and increases neurogenesis of neural stem cells. PLoS One. 2015; 10(2):e0118188. Kong SY, Park MH, Lee M, Kim JO, Lee HR, Han BW, Svendsen CN, Sung SH, Kim HJ. PMID: 25706719; PMCID: PMC4338147.
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    100. A Subsequent Human Neural Progenitor Transplant into the Degenerate Retina Does Not Compromise Initial Graft Survival or Therapeutic Efficacy. Transl Vis Sci Technol. 2015 Feb; 4(1):7. Lu B, Lin Y, Tsai Y, Girman S, Adamus G, Jones MK, Shelley B, Svendsen CN, Wang S. PMID: 25694843; PMCID: PMC4324446.
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    101. Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease. Sci Transl Med. 2014 Dec 24; 6(268):268ra178. Lu XH, Mattis VB, Wang N, Al-Ramahi I, van den Berg N, Fratantoni SA, Waldvogel H, Greiner E, Osmand A, Elzein K, Xiao J, Dijkstra S, de Pril R, Vinters HV, Faull R, Signer E, Kwak S, Marugan JJ, Botas J, Fischer DF, Svendsen CN, Munoz-Sanjuan I, Yang XW. PMID: 25540325.
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    102. Delayed disease onset and extended survival in the SOD1G93A rat model of amyotrophic lateral sclerosis after suppression of mutant SOD1 in the motor cortex. J Neurosci. 2014 Nov 19; 34(47):15587-600. Thomsen GM, Gowing G, Latter J, Chen M, Vit JP, Staggenborg K, Avalos P, Alkaslasi M, Ferraiuolo L, Likhite S, Kaspar BK, Svendsen CN. PMID: 25411487; PMCID: PMC4298650.
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    103. Reliable generation of induced pluripotent stem cells from human lymphoblastoid cell lines. Stem Cells Transl Med. 2014 Dec; 3(12):1429-34. Barrett R, Ornelas L, Yeager N, Mandefro B, Sahabian A, Lenaeus L, Targan SR, Svendsen CN, Sareen D. PMID: 25298370; PMCID: PMC4250214.
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    104. Astrocytes show reduced support of motor neurons with aging that is accelerated in a rodent model of ALS. Neurobiol Aging. 2015 Feb; 36(2):1130-9. Das MM, Svendsen CN. PMID: 25443290.
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    105. Differentiation of human limbal-derived induced pluripotent stem cells into limbal-like epithelium. Stem Cells Transl Med. 2014 Sep; 3(9):1002-12. Sareen D, Saghizadeh M, Ornelas L, Winkler MA, Narwani K, Sahabian A, Funari VA, Tang J, Spurka L, Punj V, Maguen E, Rabinowitz YS, Svendsen CN, Ljubimov AV. PMID: 25069777; PMCID: PMC4149305.
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    106. A cGMP-applicable expansion method for aggregates of human neural stem and progenitor cells derived from pluripotent stem cells or fetal brain tissue. J Vis Exp. 2014 Jun 15; (88). Shelley BC, Gowing G, Svendsen CN. PMID: 24962813; PMCID: PMC4195512.
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    107. Glial cell line-derived neurotrophic factor-secreting human neural progenitors show long-term survival, maturation into astrocytes, and no tumor formation following transplantation into the spinal cord of immunocompromised rats. Neuroreport. 2014 Apr 16; 25(6):367-72. Gowing G, Shelley B, Staggenborg K, Hurley A, Avalos P, Victoroff J, Latter J, Garcia L, Svendsen CN. PMID: 24284956; PMCID: PMC3969154.
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    108. Human induced pluripotent stem cells are a novel source of neural progenitor cells (iNPCs) that migrate and integrate in the rodent spinal cord. J Comp Neurol. 2014 Aug 15; 522(12):2707-28. Sareen D, Gowing G, Sahabian A, Staggenborg K, Paradis R, Avalos P, Latter J, Ornelas L, Garcia L, Svendsen CN. PMID: 24610630; PMCID: PMC4070510.
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    109. Patient-derived skeletal dysplasia induced pluripotent stem cells display abnormal chondrogenic marker expression and regulation by BMP2 and TGFβ1. Stem Cells Dev. 2014 Jul 01; 23(13):1464-78. Saitta B, Passarini J, Sareen D, Ornelas L, Sahabian A, Argade S, Krakow D, Cohn DH, Svendsen CN, Rimoin DL. PMID: 24559391; PMCID: PMC4066255.
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    110. In vivo tracking of human neural progenitor cells in the rat brain using bioluminescence imaging. J Neurosci Methods. 2014 May 15; 228:67-78. Bernau K, Lewis CM, Petelinsek AM, Benink HA, Zimprich CA, Meyerand ME, Suzuki M, Svendsen CN. PMID: 24675049; PMCID: PMC5054746.
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    111. The past, present and future of stem cell clinical trials for ALS. Exp Neurol. 2014 Dec; 262 Pt B:127-37. Thomsen GM, Gowing G, Svendsen S, Svendsen CN. PMID: 24613827.
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    112. Sca1⁺ murine pituitary adenoma cells show tumor-growth advantage. Endocr Relat Cancer. 2014 Apr; 21(2):203-16. Donangelo I, Ren SG, Eigler T, Svendsen C, Melmed S. PMID: 24481638; PMCID: PMC3978815.
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    113. Ocular changes in TgF344-AD rat model of Alzheimer's disease. Invest Ophthalmol Vis Sci. 2014 Jan 29; 55(1):523-34. Tsai Y, Lu B, Ljubimov AV, Girman S, Ross-Cisneros FN, Sadun AA, Svendsen CN, Cohen RM, Wang S. PMID: 24398104; PMCID: PMC3907137.
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    114. Neonatal immune-tolerance in mice does not prevent xenograft rejection. Exp Neurol. 2014 Apr; 254:90-8. Mattis VB, Wakeman DR, Tom C, Dodiya HB, Yeung SY, Tran AH, Bernau K, Ornelas L, Sahabian A, Reidling J, Sareen D, Thompson LM, Kordower JH, Svendsen CN. PMID: 24440640; PMCID: PMC3954854.
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    115. Stimulation of GABA-induced Ca2+ influx enhances maturation of human induced pluripotent stem cell-derived neurons. PLoS One. 2013; 8(11):e81031. Rushton DJ, Mattis VB, Svendsen CN, Allen ND, Kemp PJ. PMID: 24278369; PMCID: PMC3838360.
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    116. A simple alkaline method for decellularizing human amniotic membrane for cell culture. PLoS One. 2013; 8(11):e79632. Saghizadeh M, Winkler MA, Kramerov AA, Hemmati DM, Ghiam CA, Dimitrijevich SD, Sareen D, Ornelas L, Ghiasi H, Brunken WJ, Maguen E, Rabinowitz YS, Svendsen CN, Jirsova K, Ljubimov AV. PMID: 24236148; PMCID: PMC3827346.
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    117. Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion. Sci Transl Med. 2013 Oct 23; 5(208):208ra149. Sareen D, O'Rourke JG, Meera P, Muhammad AK, Grant S, Simpkinson M, Bell S, Carmona S, Ornelas L, Sahabian A, Gendron T, Petrucelli L, Baughn M, Ravits J, Harms MB, Rigo F, Bennett CF, Otis TS, Svendsen CN, Baloh RH. PMID: 24154603; PMCID: PMC4090945.
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    118. Back to the future: how human induced pluripotent stem cells will transform regenerative medicine. Hum Mol Genet. 2013 Oct 15; 22(R1):R32-8. Svendsen CN. PMID: 23945396; PMCID: PMC3782070.
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    119. Synergistic effects of GDNF and VEGF on lifespan and disease progression in a familial ALS rat model. Mol Ther. 2013 Aug; 21(8):1602-10. Krakora D, Mulcrone P, Meyer M, Lewis C, Bernau K, Gowing G, Zimprich C, Aebischer P, Svendsen CN, Suzuki M. PMID: 23712039; PMCID: PMC3734670.
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    120. EZ spheres: a stable and expandable culture system for the generation of pre-rosette multipotent stem cells from human ESCs and iPSCs. Stem Cell Res. 2013 May; 10(3):417-427. Ebert AD, Shelley BC, Hurley AM, Onorati M, Castiglioni V, Patitucci TN, Svendsen SP, Mattis VB, McGivern JV, Schwab AJ, Sareen D, Kim HW, Cattaneo E, Svendsen CN. PMID: 23474892; PMCID: PMC3786426.
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    121. Neural Stem Cells Derived by Small Molecules Preserve Vision. Transl Vis Sci Technol. 2013 Jan; 2(1):1. Lu B, Morgans CW, Girman S, Luo J, Zhao J, Du H, Lim S, Ding S, Svendsen C, Zhang K, Wang S. PMID: 24049711; PMCID: PMC3763886.
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    122. Intermittent hypoxia and stem cell implants preserve breathing capacity in a rodent model of amyotrophic lateral sclerosis. Am J Respir Crit Care Med. 2013 Mar 01; 187(5):535-42. Nichols NL, Gowing G, Satriotomo I, Nashold LJ, Dale EA, Suzuki M, Avalos P, Mulcrone PL, McHugh J, Svendsen CN, Mitchell GS. PMID: 23220913; PMCID: PMC3733409.
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    123. The in vitro survival of human monosomies and trisomies as embryonic stem cells. Stem Cell Res. 2012 Nov; 9(3):218-24. Biancotti JC, Narwani K, Mandefro B, Golan-Lev T, Buehler N, Hill D, Svendsen CN, Benvenisty N. PMID: 22892439.
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    124. Rapid genetic targeting of pial surface neural progenitors and immature neurons by neonatal electroporation. Neural Dev. 2012 Jul 10; 7:26. Breunig JJ, Gate D, Levy R, Rodriguez J, Kim GB, Danielpour M, Svendsen CN, Town T. PMID: 22776033; PMCID: PMC3479020.
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    125. Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy. PLoS One. 2012; 7(6):e39113. Sareen D, Ebert AD, Heins BM, McGivern JV, Ornelas L, Svendsen CN. PMID: 22723941; PMCID: PMC3378532.
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    126. Gene expression changes in the MAPK pathway in both Fragile X and Down syndrome human neural progenitor cells. Am J Stem Cells. 2012 Jun 30; 1(2):154-162. McMillan EL, Kamps AL, Lake SS, Svendsen CN, Bhattacharyya A. PMID: 22822472; PMCID: PMC3399245.
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    127. Gonadectomy and dehydroepiandrosterone (DHEA) do not modulate disease progression in the G93A mutant SOD1 rat model of amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2012 May; 13(3):311-4. Hayes-Punzo A, Mulcrone P, Meyer M, McHugh J, Svendsen CN, Suzuki M. PMID: 22409357; PMCID: PMC3644484.
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    128. Clinical translation of stem cells in neurodegenerative disorders. Cell Stem Cell. 2012 Feb 03; 10(2):151-5. Lindvall O, Barker RA, Brüstle O, Isacson O, Svendsen CN. PMID: 22305565; PMCID: PMC3982832.
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    129. Stem cell transplantation for motor neuron disease: current approaches and future perspectives. Neurotherapeutics. 2011 Oct; 8(4):591-606. Gowing G, Svendsen CN. PMID: 21904789; PMCID: PMC3210365.
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    130. Blood-brain barrier modeling with co-cultured neural progenitor cell-derived astrocytes and neurons. J Neurochem. 2011 Nov; 119(3):507-20. Lippmann ES, Weidenfeller C, Svendsen CN, Shusta EV. PMID: 21854389; PMCID: PMC3192906.
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    131. BDNF-, IGF-1- and GDNF-secreting human neural progenitor cells rescue amyloid β-induced toxicity in cultured rat septal neurons. Neurochem Res. 2012 Jan; 37(1):143-52. Kitiyanant N, Kitiyanant Y, Svendsen CN, Thangnipon W. PMID: 21909955.
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    132. Gene editing in stem cells hits the target. Cell Stem Cell. 2011 Aug 05; 9(2):93-4. Kim HW, Svendsen CN. PMID: 21816359.
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    133. Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain. Brain. 2011 Jun; 134(Pt 6):1777-89. Andres RH, Horie N, Slikker W, Keren-Gill H, Zhan K, Sun G, Manley NC, Pereira MP, Sheikh LA, McMillan EL, Schaar BT, Svendsen CN, Bliss TM, Steinberg GK. PMID: 21616972; PMCID: PMC3102243.
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    134. Induced pluripotent stem cells: a new revolution for clinical neurology? Lancet Neurol. 2011 Apr; 10(4):383-94. Mattis VB, Svendsen CN. PMID: 21435601.
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    135. Gene therapy-mediated delivery of targeted cytotoxins for glioma therapeutics. Proc Natl Acad Sci U S A. 2010 Nov 16; 107(46):20021-6. Candolfi M, Xiong W, Yagiz K, Liu C, Muhammad AK, Puntel M, Foulad D, Zadmehr A, Ahlzadeh GE, Kroeger KM, Tesarfreund M, Lee S, Debinski W, Sareen D, Svendsen CN, Rodriguez R, Lowenstein PR, Castro MG. PMID: 21030678; PMCID: PMC2993419.
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    136. Transplantation of human glial-restricted neural precursors into injured spinal cord promotes functional and sensory recovery without causing allodynia. Cytotherapy. 2011 Jan; 13(1):61-8. Alexanian AR, Svendsen CN, Crowe MJ, Kurpad SN. PMID: 20735167.
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    139. Human stem cells and drug screening: opportunities and challenges. Nat Rev Drug Discov. 2010 05; 9(5):367-72. Ebert AD, Svendsen CN. PMID: 20339370.
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    141. Acute glial activation by stab injuries does not lead to overt damage or motor neuron degeneration in the G93A mutant SOD1 rat model of amyotrophic lateral sclerosis. Exp Neurol. 2010 Feb; 221(2):346-52. Suzuki M, Klein S, Wetzel EA, Meyer M, McHugh J, Tork C, Hayes A, Svendsen CN. PMID: 20005223; PMCID: PMC2839070.
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    143. Cervical spinal cord therapeutics delivery: preclinical safety validation of a stabilized microinjection platform. Neurosurgery. 2009 Oct; 65(4):754-61; discussion 761-2. Riley J, Federici T, Park J, Suzuki M, Franz CK, Tork C, McHugh J, Teng Q, Svendsen C, Boulis NM. PMID: 19834381; PMCID: PMC2764319.
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    145. Regionally specified human neural progenitor cells derived from the mesencephalon and forebrain undergo increased neurogenesis following overexpression of ASCL1. Stem Cells. 2009 Feb; 27(2):390-8. Kim HJ, McMillan E, Han F, Svendsen CN. PMID: 19008346.
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    147. Regulation of prenatal human retinal neurosphere growth and cell fate potential by retinal pigment epithelium and Mash1. Stem Cells. 2008 Dec; 26(12):3182-93. Gamm DM, Wright LS, Capowski EE, Shearer RL, Meyer JS, Kim HJ, Schneider BL, Melvan JN, Svendsen CN. PMID: 18802035; PMCID: PMC3127245.
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    149. Isolating, expanding, and infecting human and rodent fetal neural progenitor cells. Curr Protoc Stem Cell Biol. 2008 Sep; Chapter 2:Unit 2D.2. Ebert AD, McMillan EL, Svendsen CN. PMID: 18819085.
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    150. Long-term vision rescue by human neural progenitors in a rat model of photoreceptor degeneration. Invest Ophthalmol Vis Sci. 2008 Jul; 49(7):3201-6. Wang S, Girman S, Lu B, Bischoff N, Holmes T, Shearer R, Wright LS, Svendsen CN, Gamm DM, Lund RD. PMID: 18579765; PMCID: PMC3055787.
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    152. Combining growth factor and stem cell therapy for amyotrophic lateral sclerosis. Trends Neurosci. 2008 Apr; 31(4):192-8. Suzuki M, Svendsen CN. PMID: 18329734.
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    157. A high concentration of epidermal growth factor increases the growth and survival of neurogenic radial glial cells within human neurosphere cultures. Stem Cells. 2008 Feb; 26(2):348-55. Nelson AD, Suzuki M, Svendsen CN. PMID: 18032704.
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    158. Human neural progenitor cells over-expressing IGF-1 protect dopamine neurons and restore function in a rat model of Parkinson's disease. Exp Neurol. 2008 Jan; 209(1):213-23. Ebert AD, Beres AJ, Barber AE, Svendsen CN. PMID: 18061591.
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    167. Musashi1 antigen expression in human fetal germinal matrix development. Exp Neurol. 2006 Oct; 201(2):515-8. Chan C, Moore BE, Cotman CW, Okano H, Tavares R, Hovanesian V, Pinar H, Johanson CE, Svendsen CN, Stopa EG. PMID: 16777095.
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    168. Human progenitor cells isolated from the developing cortex undergo decreased neurogenesis and eventual senescence following expansion in vitro. Exp Cell Res. 2006 Jul 01; 312(11):2107-20. Wright LS, Prowse KR, Wallace K, Linskens MH, Svendsen CN. PMID: 16631163.
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    169. Massively parallel signature sequencing profiling of fetal human neural precursor cells. Stem Cells Dev. 2006 Apr; 15(2):232-44. Cai J, Shin S, Wright L, Liu Y, Zhou D, Xue H, Khrebtukova I, Mattson MP, Svendsen CN, Rao MS. PMID: 16646669.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    170. 5-Bromo-2'-deoxyuridine is selectively toxic to neuronal precursors in vitro. Eur J Neurosci. 2005 Dec; 22(11):2965-70. Caldwell MA, He X, Svendsen CN. PMID: 16324131.
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    171. EGF and FGF-2 responsiveness of rat and mouse neural precursors derived from the embryonic CNS. Brain Res Bull. 2005 Dec 15; 68(1-2):83-94. Kelly CM, Tyers P, Borg MT, Svendsen CN, Dunnett SB, Rosser AE. PMID: 16325008.
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    172. Human retinal progenitor cells grown as neurospheres demonstrate time-dependent changes in neuronal and glial cell fate potential. Ann N Y Acad Sci. 2005 May; 1049:107-17. Gamm DM, Nelson AD, Svendsen CN. PMID: 15965111.
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    173. GDNF delivery using human neural progenitor cells in a rat model of ALS. Hum Gene Ther. 2005 Apr; 16(4):509-21. Klein SM, Behrstock S, McHugh J, Hoffmann K, Wallace K, Suzuki M, Aebischer P, Svendsen CN. PMID: 15871682.
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    174. Stem cells in the injured spinal cord: reducing the pain and increasing the gain. Nat Neurosci. 2005 Mar; 8(3):259-60. Klein S, Svendsen CN. PMID: 15746908.
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    175. Rotenone-induced caspase 9/3-independent and -dependent cell death in undifferentiated and differentiated human neural stem cells. J Neurochem. 2005 Feb; 92(3):462-76. Li J, Spletter ML, Johnson DA, Wright LS, Svendsen CN, Johnson JA. PMID: 15659217.
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    176. A new tool in the battle against Alzheimer's disease and aging: ex vivo gene therapy. Rejuvenation Res. 2005; 8(3):131-4. Ebert AD, Svendsen CN. PMID: 16144466.
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    177. Stabilization of Nrf2 by tBHQ confers protection against oxidative stress-induced cell death in human neural stem cells. Toxicol Sci. 2005 Feb; 83(2):313-28. Li J, Johnson D, Calkins M, Wright L, Svendsen C, Johnson J. PMID: 15525690.
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    178. Differential generation of oligodendrocytes from human and rodent embryonic spinal cord neural precursors. Glia. 2004 Sep; 47(4):314-24. Chandran S, Compston A, Jauniaux E, Gilson J, Blakemore W, Svendsen C. PMID: 15293229.
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    179. Heparin stabilizes FGF-2 and modulates striatal precursor cell behavior in response to EGF. Exp Neurol. 2004 Aug; 188(2):408-20. Caldwell MA, Garcion E, terBorg MG, He X, Svendsen CN. PMID: 15246840.
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    180. Human neural stem cell transplants improve motor function in a rat model of Huntington's disease. J Comp Neurol. 2004 Jul 19; 475(2):211-9. McBride JL, Behrstock SP, Chen EY, Jakel RJ, Siegel I, Svendsen CN, Kordower JH. PMID: 15211462.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    181. Combining growth factors, stem cells, and gene therapy for the aging brain. Ann N Y Acad Sci. 2004 Jun; 1019:5-14. Behrstock S, Svendsen CN. PMID: 15246984.
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    182. Differentiation and migration of long term expanded human neural progenitors in a partial lesion model of Parkinson's disease. Int J Biochem Cell Biol. 2004 Apr; 36(4):702-13. Burnstein RM, Foltynie T, He X, Menon DK, Svendsen CN, Caldwell MA. PMID: 15010333.
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    183. Stem cells for Parkinson disease and ALS: replacement or protection? Nat Med. 2004 Mar; 10(3):224-5. Svendsen CN, Langston JW. PMID: 14991036.
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    184. Mitotic and neurogenic effects of dehydroepiandrosterone (DHEA) on human neural stem cell cultures derived from the fetal cortex. Proc Natl Acad Sci U S A. 2004 Mar 02; 101(9):3202-7. Suzuki M, Wright LS, Marwah P, Lardy HA, Svendsen CN. PMID: 14973190; PMCID: PMC365767.
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    185. Using human neural stem cells to model neurological disease. Nat Rev Genet. 2004 Feb; 5(2):136-44. Jakel RJ, Schneider BL, Svendsen CN. PMID: 14735124.
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    186. Stem cells as a potential treatment of neurological disorders. Curr Opin Pharmacol. 2004 Feb; 4(1):98-104. Tai YT, Svendsen CN. PMID: 15018846.
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    187. Requirement for neurogenesis to proceed through the division of neuronal progenitors following differentiation of epidermal growth factor and fibroblast growth factor-2-responsive human neural stem cells. Stem Cells. 2004; 22(5):798-811. Ostenfeld T, Svendsen CN. PMID: 15342944.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    188. Gene expression in human neural stem cells: effects of leukemia inhibitory factor. J Neurochem. 2003 Jul; 86(1):179-95. Wright LS, Li J, Caldwell MA, Wallace K, Johnson JA, Svendsen CN. PMID: 12807438.
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    189. High efficacy of clonal growth and expansion of adult neural stem cells. Lab Invest. 2003 Jul; 83(7):949-62. Wachs FP, Couillard-Despres S, Engelhardt M, Wilhelm D, Ploetz S, Vroemen M, Kaesbauer J, Uyanik G, Klucken J, Karl C, Tebbing J, Svendsen C, Weidner N, Kuhn HG, Winkler J, Aigner L. PMID: 12861035.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    190. Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease. Nat Med. 2003 May; 9(5):589-95. Gill SS, Patel NK, Hotton GR, O'Sullivan K, McCarter R, Bunnage M, Brooks DJ, Svendsen CN, Heywood P. PMID: 12669033.
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    191. Neurospheres modified to produce glial cell line-derived neurotrophic factor increase the survival of transplanted dopamine neurons. J Neurosci Res. 2002 Sep 15; 69(6):955-65. Ostenfeld T, Tai YT, Martin P, Déglon N, Aebischer P, Svendsen CN. PMID: 12205689.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    192. The amazing astrocyte. Nature. 2002 May 02; 417(6884):29-32. Svendsen CN. PMID: 11986650.
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    193. Stem cells for neurodegenerative disorders: where can we go from here? BioDrugs. 2002; 16(6):389-401. Le Belle JE, Svendsen CN. PMID: 12463763.
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