Clive N Svendsen

Title(s)Professor-in-Residence, Medicine
SchoolMedicine
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    A microphysiologic multicellular organ-on-chip to inform clinical trials in FTD/ALS
    NIH UG3TR003264Jul 1, 2020 - May 31, 2025
    Role: Co-Principal Investigator
    Multi-organ-on-chip device for modeling opioid reinforcement and withdrawal, and the negative affective component of pain: a therapeutic screening tool.
    NIH UG3TR003148Sep 26, 2019 - Jan 31, 2022
    Role: Co-Principal Investigator
    Development of a Microphysiological Organ-on-Chip System to Model Amyotrophic
    NIH UG3NS105703Sep 15, 2017 - Feb 28, 2023
    Role: Principal Investigator
    Development of a Microphysiological Organ-on-Chip System to Model Amyotrophic
    NIH UH3NS105703Sep 15, 2017 - Feb 28, 2023
    Role: Principal Investigator
    A genetic model of inflammatory bowel disease using human intestinal organoids.
    NIH R56DK106202Sep 5, 2015 - Aug 31, 2017
    Role: Co-Principal Investigator
    Neuron and Glial Cellular Signatures from Normal and Diseased iPS Cells
    NIH U54NS091046Sep 30, 2014 - Jun 30, 2021
    Role: Co-Principal Investigator
    Tracking cardiac engraftment and viability of MiPSC by MRI
    NIH R44EB019239Sep 1, 2014 - May 31, 2018
    Role: Co-Principal Investigator
    An iPS Disease-in-a-Dish Model of Familial Alzheimers
    NIH RF1AG042951Sep 1, 2012 - Aug 31, 2014
    Role: Co-Principal Investigator
    The Huntington's Disease iPS Consortium
    NIH RC2NS069422Sep 30, 2009 - Aug 31, 2012
    Role: Co-Principal Investigator
    Directing the Fate of Neural Stem Cells with Engineered Gradients of FGF-2
    NIH R21NS060047Apr 1, 2008 - Mar 31, 2010
    Role: Principal Investigator
    Stem Cell Therapy and Growth Factor Therapy for ALS
    NIH P01NS057778Sep 1, 2007 - Mar 31, 2012
    Role: Principal Investigator
    Stem Cell Research Training Program
    NIH T32AG027566May 1, 2005 - Jul 31, 2011
    Role: Co-Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Longitudinal Quantitative MRI Provides Responsive Outcome Measures for Early and Late Muscle Changes in ALS. Muscle Nerve. 2024 Nov 29. Diaz F, Thornton JS, Wastling SS, Asaab A, Morrow JM, Zafeiropoulos N, Bresee C, Allred P, Avalos P, Lewis RA, Baloh RH, Svendsen CN. PMID: 39611310.
      View in: PubMed   Mentions:    Fields:    
    2. Surface tension enables induced pluripotent stem cell culture in commercially available hardware during spaceflight. NPJ Microgravity. 2024 Oct 15; 10(1):97. Mozneb M, Arzt M, Mesci P, Martin DMN, Pohlman S, Lawless G, Doraisingam S, Al Neyadi S, Barnawi R, Al Qarni A, Whitson PA, Shoffner J, Stoudemire J, Countryman S, Svendsen CN, Sharma A. PMID: 39402072; PMCID: PMC11473755.
      View in: PubMed   Mentions:
    3. Cell therapy for neurological disorders. Nat Med. 2024 Oct; 30(10):2756-2770. Svendsen SP, Svendsen CN. PMID: 39407034.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Disease related changes in ATAC-seq of iPSC-derived motor neuron lines from ALS patients and controls. Nat Commun. 2024 May 02; 15(1):3606. Tsitkov S, Valentine K, Kozareva V, Donde A, Frank A, Lei S, Answer ALS Consortium, E Van Eyk J, Finkbeiner S, Rothstein JD, Thompson LM, Sareen D, Svendsen CN, Fraenkel E. PMID: 38697975; PMCID: PMC11066062.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Survival of the fittest glia. Nat Biotechnol. 2024 May; 42(5):700-702. Moser VA, Svendsen CN. PMID: 37640947.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. SOX9 switch links regeneration to fibrosis at the single-cell level in mammalian kidneys. Science. 2024 Feb 23; 383(6685):eadd6371. Aggarwal S, Wang Z, Rincon Fernandez Pacheco D, Rinaldi A, Rajewski A, Callemeyn J, Van Loon E, Lamarthée B, Covarrubias AE, Hou J, Yamashita M, Akiyama H, Karumanchi SA, Svendsen CN, Noble PW, Jordan SC, Breunig JJ, Naesens M, Cippà PE, Kumar S. PMID: 38386758; PMCID: PMC11345873.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    7. Multi-lineage heart-chip models drug cardiotoxicity and enhances maturation of human stem cell-derived cardiovascular cells. Lab Chip. 2024 02 13; 24(4):869-881. Mozneb M, Jenkins A, Sances S, Pohlman S, Workman MJ, West D, Ondatje B, El-Ghazawi K, Woodbury A, Garcia VJ, Patel S, Arzt M, Dezem F, Laperle AH, Moser VA, Ho R, Yucer N, Plummer J, Barrett RJ, Svendsen CN, Sharma A. PMID: 38252454.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    8. Human Neural Progenitors Expressing GDNF Enhance Retinal Protection in a Rodent Model of Retinal Degeneration. Stem Cells Transl Med. 2023 Nov 03; 12(11):727-744. Shahin S, Tan P, Chetsawang J, Lu B, Svendsen S, Ramirez S, Conniff T, Alfaro JS, Fernandez M, Fulton A, Laperle AH, Svendsen CN, Wang S. PMID: 37786347; PMCID: PMC10630082.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    9. GMP-grade human neural progenitors delivered subretinally protect vision in rat model of retinal degeneration and survive in minipigs. J Transl Med. 2023 09 25; 21(1):650. Lu B, Avalos P, Svendsen S, Zhang C, Nocito L, Jones MK, Pieplow C, Saylor J, Ghiam S, Block A, Fernandez M, Ljubimov AV, Small K, Liao D, Svendsen CN, Wang S. PMID: 37743503; PMCID: PMC10519102.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    10. Organ-Chips Enhance the Maturation of Human iPSC-Derived Dopamine Neurons. Int J Mol Sci. 2023 Sep 18; 24(18). Otero MG, Bell S, Laperle AH, Lawless G, Myers Z, Castro MA, Villalba JM, Svendsen CN. PMID: 37762529; PMCID: PMC10531789.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    11. Reversal of dual epigenetic repression of non-canonical Wnt-5a normalises diabetic corneal epithelial wound healing and stem cells. Diabetologia. 2023 10; 66(10):1943-1958. Shah R, Spektor TM, Weisenberger DJ, Ding H, Patil R, Amador C, Song XY, Chun ST, Inzalaco J, Turjman S, Ghiam S, Jeong-Kim J, Tolstoff S, Yampolsky SV, Sawant OB, Rabinowitz YS, Maguen E, Hamrah P, Svendsen CN, Saghizadeh M, Ljubimova JY, Kramerov AA, Ljubimov AV. PMID: 37460827; PMCID: PMC10474199.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    12. Human iPSC-derived neural progenitor cells secreting GDNF provide protection in rodent models of ALS and retinal degeneration. Stem Cell Reports. 2023 08 08; 18(8):1629-1642. Laperle AH, Moser VA, Avalos P, Lu B, Wu A, Fulton A, Ramirez S, Garcia VJ, Bell S, Ho R, Lawless G, Roxas K, Shahin S, Shelest O, Svendsen S, Wang S, Svendsen CN. PMID: 37084724; PMCID: PMC10444557.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    13. Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects. Neuron. 2023 04 19; 111(8):1191-1204.e5. Workman MJ, Lim RG, Wu J, Frank A, Ornelas L, Panther L, Galvez E, Perez D, Meepe I, Lei S, Valencia V, Gomez E, Liu C, Moran R, Pinedo L, Tsitkov S, Ho R, Kaye JA, Answer ALS Consortium, Thompson T, Rothstein JD, Finkbeiner S, Fraenkel E, Sareen D, Thompson LM, Svendsen CN. PMID: 36764301; PMCID: PMC10557526.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    14. NeuroLINCS Proteomics: Defining human-derived iPSC proteomes and protein signatures of pluripotency. Sci Data. 2023 01 11; 10(1):24. Matlock AD, Vaibhav V, Holewinski R, Venkatraman V, Dardov V, Manalo DM, Shelley B, Ornelas L, Banuelos M, Mandefro B, Escalante-Chong R, Li J, Finkbeiner S, Fraenkel E, Rothstein J, Thompson L, Sareen D, Svendsen CN, NIH NeuroLINCS Consortium, Van Eyk JE. PMID: 36631473; PMCID: PMC9834231.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    15. Tissue clearing of human iPSC-derived organ-chips enables high resolution imaging and analysis. Lab Chip. 2022 Oct 25; 22(21):4246-4255. Ondatje BN, Sances S, Workman MJ, Svendsen CN. PMID: 36205191; PMCID: PMC9595176.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    16. Transplantation of human neural progenitor cells secreting GDNF into the spinal cord of patients with ALS: a phase 1/2a trial. Nat Med. 2022 09; 28(9):1813-1822. Baloh RH, Johnson JP, Avalos P, Allred P, Svendsen S, Gowing G, Roxas K, Wu A, Donahue B, Osborne S, Lawless G, Shelley B, Wheeler K, Prina C, Fine D, Kendra-Romito T, Stokes H, Manoukian V, Muthukumaran A, Garcia L, Bañuelos MG, Godoy M, Bresee C, Yu H, Drazin D, Ross L, Naruse R, Babu H, Macklin EA, Vo A, Elsayegh A, Tourtellotte W, Maya M, Burford M, Diaz F, Patil CG, Lewis RA, Svendsen CN. PMID: 36064599; PMCID: PMC9499868.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    17. Lineage tracing: The gold standard to claim direct reprogramming in vivo. Mol Ther. 2022 03 02; 30(3):988-989. Svendsen CN, Sofroniew MV. PMID: 35123656; PMCID: PMC8899699.
      View in: PubMed   Mentions: 5     Fields:    
    18. Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines. Nat Neurosci. 2022 02; 25(2):226-237. Baxi EG, Thompson T, Li J, Kaye JA, Lim RG, Wu J, Ramamoorthy D, Lima L, Vaibhav V, Matlock A, Frank A, Coyne AN, Landin B, Ornelas L, Mosmiller E, Thrower S, Farr SM, Panther L, Gomez E, Galvez E, Perez D, Meepe I, Lei S, Mandefro B, Trost H, Pinedo L, Banuelos MG, Liu C, Moran R, Garcia V, Workman M, Ho R, Wyman S, Roggenbuck J, Harms MB, Stocksdale J, Miramontes R, Wang K, Venkatraman V, Holewenski R, Sundararaman N, Pandey R, Manalo DM, Donde A, Huynh N, Adam M, Wassie BT, Vertudes E, Amirani N, Raja K, Thomas R, Hayes L, Lenail A, Cerezo A, Luppino S, Farrar A, Pothier L, Prina C, Morgan T, Jamil A, Heintzman S, Jockel-Balsarotti J, Karanja E, Markway J, McCallum M, Joslin B, Alibazoglu D, Kolb S, Ajroud-Driss S, Baloh R, Heitzman D, Miller T, Glass JD, Patel-Murray NL, Yu H, Sinani E, Vigneswaran P, Sherman AV, Ahmad O, Roy P, Beavers JC, Zeiler S, Krakauer JW, Agurto C, Cecchi G, Bellard M, Raghav Y, Sachs K, Ehrenberger T, Bruce E, Cudkowicz ME, Maragakis N, Norel R, Van Eyk JE, Finkbeiner S, Berry J, Sareen D, Thompson LM, Fraenkel E, Svendsen CN, Rothstein JD. PMID: 35115730; PMCID: PMC8825283.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    19. Getting the upper hand in ALS. Gene Ther. 2022 04; 29(3-4):113-114. Svendsen CN. PMID: 35046530; PMCID: PMC9013663.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    20. Human iPSC-derived fallopian tube organoids with BRCA1 mutation recapitulate early-stage carcinogenesis. Cell Rep. 2021 12 28; 37(13):110146. Yucer N, Ahdoot R, Workman MJ, Laperle AH, Recouvreux MS, Kurowski K, Naboulsi DJ, Liang V, Qu Y, Plummer JT, Gayther SA, Orsulic S, Karlan BY, Svendsen CN. PMID: 34965417; PMCID: PMC9000920.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    21. An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients. iScience. 2021 Nov 19; 24(11):103221. NeuroLINCS Consortium, Li J, Lim RG, Kaye JA, Dardov V, Coyne AN, Wu J, Milani P, Cheng A, Thompson TG, Ornelas L, Frank A, Adam M, Banuelos MG, Casale M, Cox V, Escalante-Chong R, Daigle JG, Gomez E, Hayes L, Holewenski R, Lei S, Lenail A, Lima L, Mandefro B, Matlock A, Panther L, Patel-Murray NL, Pham J, Ramamoorthy D, Sachs K, Shelley B, Stocksdale J, Trost H, Wilhelm M, Venkatraman V, Wassie BT, Wyman S, Yang S, NYGC ALS Consortium, Van Eyk JE, Lloyd TE, Finkbeiner S, Fraenkel E, Rothstein JD, Sareen D, Svendsen CN, Thompson LM. PMID: 34746695; PMCID: PMC8554488.
      View in: PubMed   Mentions: 20  
    22. Microglial transcription profiles in mouse and human are driven by APOE4 and sex. iScience. 2021 Nov 19; 24(11):103238. Moser VA, Workman MJ, Hurwitz SJ, Lipman RM, Pike CJ, Svendsen CN. PMID: 34746703; PMCID: PMC8551075.
      View in: PubMed   Mentions: 8  
    23. Oligodendrocyte progenitor cell maturation is dependent on dual function of MCT8 in the transport of thyroid hormone across brain barriers and the plasma membrane. Glia. 2021 09; 69(9):2146-2159. Vatine GD, Shelest O, Barriga BK, Ofan R, Rabinski T, Mattis VB, Heuer H, Svendsen CN. PMID: 33956384.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    24. Antiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication. Cell Rep. 2021 04 06; 35(1):108940. Garcia G, Sharma A, Ramaiah A, Sen C, Purkayastha A, Kohn DB, Parcells MS, Beck S, Kim H, Bakowski MA, Kirkpatrick MG, Riva L, Wolff KC, Han B, Yuen C, Ulmert D, Purbey PK, Scumpia P, Beutler N, Rogers TF, Chatterjee AK, Gabriel G, Bartenschlager R, Gomperts B, Svendsen CN, Betz UAK, Damoiseaux RD, Arumugaswami V. PMID: 33784499; PMCID: PMC7969873.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    25. Modeling Intestinal Epithelial Response to Interferon-γ in Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids. Int J Mol Sci. 2020 Dec 30; 22(1). Workman MJ, Troisi E, Targan SR, Svendsen CN, Barrett RJ. PMID: 33396621; PMCID: PMC7794932.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    26. Cross-Comparison of Human iPSC Motor Neuron Models of Familial and Sporadic ALS Reveals Early and Convergent Transcriptomic Disease Signatures. Cell Syst. 2021 02 17; 12(2):159-175.e9. Ho R, Workman MJ, Mathkar P, Wu K, Kim KJ, O'Rourke JG, Kellogg M, Montel V, Banuelos MG, Arogundade OA, Diaz-Garcia S, Oheb D, Huang S, Khrebtukova I, Watson L, Ravits J, Taylor K, Baloh RH, Svendsen CN. PMID: 33382996; PMCID: PMC7897311.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    27. Novel nanopolymer RNA therapeutics normalize human diabetic corneal wound healing and epithelial stem cells. Nanomedicine. 2021 02; 32:102332. Kramerov AA, Shah R, Ding H, Holler E, Turjman S, Rabinowitz YS, Ghiam S, Maguen E, Svendsen CN, Saghizadeh M, Ljubimova JY, Ljubimov AV. PMID: 33181273; PMCID: PMC8107190.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    28. G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD. Neuron. 2020 09 23; 107(6):1124-1140.e11. Coyne AN, Zaepfel BL, Hayes L, Fitchman B, Salzberg Y, Luo EC, Bowen K, Trost H, Aigner S, Rigo F, Yeo GW, Harel A, Svendsen CN, Sareen D, Rothstein JD. PMID: 32673563; PMCID: PMC8077944.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    29. Human iPSC-Derived Cardiomyocytes Are Susceptible to SARS-CoV-2 Infection. Cell Rep Med. 2020 07 21; 1(4):100052. Sharma A, Garcia G, Wang Y, Plummer JT, Morizono K, Arumugaswami V, Svendsen CN. PMID: 32835305; PMCID: PMC7323681.
      View in: PubMed   Mentions: 193     Fields:    
    30. Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns. Mol Autism. 2020 06 19; 11(1):52. Das Sharma S, Pal R, Reddy BK, Selvaraj BT, Raj N, Samaga KK, Srinivasan DJ, Ornelas L, Sareen D, Livesey MR, Bassell GJ, Svendsen CN, Kind PC, Chandran S, Chattarji S, Wyllie DJA. PMID: 32560741; PMCID: PMC7304215.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    31. Immunosuppressive Functions of M2 Macrophages Derived from iPSCs of Patients with ALS and Healthy Controls. iScience. 2020 Jun 26; 23(6):101192. Zhao W, Beers DR, Thonhoff JR, Thome AD, Faridar A, Wang J, Wen S, Ornelas L, Sareen D, Goodridge HS, Svendsen CN, Appel SH. PMID: 32521508; PMCID: PMC7286967.
      View in: PubMed   Mentions: 19  
    32. Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936. Stem Cell Res. 2020 07; 46:101851. Toombs J, Panther L, Ornelas L, Liu C, Gomez E, Martín-Ibáñez R, Cox SR, Ritchie SJ, Harris SE, Taylor A, Redmond P, Russ TC, Murphy L, Cooper JD, Burr K, Selvaraj BT, Browne C, Svendsen CN, Cowley SA, Deary IJ, Chandran S, Spires-Jones TL, Sareen D. PMID: 32450543; PMCID: PMC7347008.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    33. Recent advances in human iPSC-derived models of the blood-brain barrier. Fluids Barriers CNS. 2020 Apr 22; 17(1):30. Workman MJ, Svendsen CN. PMID: 32321511; PMCID: PMC7178976.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    34. Human iPSC-Derived Cardiomyocytes are Susceptible to SARS-CoV-2 Infection. bioRxiv. 2020 Apr 21. Sharma A, Garcia G, Arumugaswami V, Svendsen CN. PMID: 32511402; PMCID: PMC7263549.
      View in: PubMed   Mentions:
    35. Multi-lineage Human iPSC-Derived Platforms for Disease Modeling and Drug Discovery. Cell Stem Cell. 2020 03 05; 26(3):309-329. Sharma A, Sances S, Workman MJ, Svendsen CN. PMID: 32142662; PMCID: PMC7159985.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansAnimalsCells
    36. Generation of a Human iPSC-Based Blood-Brain Barrier Chip. J Vis Exp. 2020 03 02; (157). Jagadeesan S, Workman MJ, Herland A, Svendsen CN, Vatine GD. PMID: 32176199.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    37. Development of Physiologically Responsive Human iPSC-Derived Intestinal Epithelium to Study Barrier Dysfunction in IBD. Int J Mol Sci. 2020 Feb 20; 21(4). Gleeson JP, Estrada HQ, Yamashita M, Svendsen CN, Targan SR, Barrett RJ. PMID: 32093254; PMCID: PMC7073090.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    38. Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support. Front Neurosci. 2019; 13:669. Garcia VJ, Rushton DJ, Tom CM, Allen ND, Kemp PJ, Svendsen CN, Mattis VB. PMID: 31316341; PMCID: PMC6610155.
      View in: PubMed   Mentions: 32  
    39. Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications. Cell Stem Cell. 2019 06 06; 24(6):995-1005.e6. Vatine GD, Barrile R, Workman MJ, Sances S, Barriga BK, Rahnama M, Barthakur S, Kasendra M, Lucchesi C, Kerns J, Wen N, Spivia WR, Chen Z, Van Eyk J, Svendsen CN. PMID: 31173718.
      View in: PubMed   Mentions: 251     Fields:    Translation:HumansCells
    40. In Vitro and In Vivo Proteomic Comparison of Human Neural Progenitor Cell-Induced Photoreceptor Survival. Proteomics. 2019 02; 19(3):e1800213. Jones MK, Lu B, Chen DZ, Spivia WR, Mercado AT, Ljubimov AV, Svendsen CN, Van Eyk JE, Wang S. PMID: 30515959; PMCID: PMC6422354.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    41. Inducible Expression of GDNF in Transplanted iPSC-Derived Neural Progenitor Cells. Stem Cell Reports. 2018 06 05; 10(6):1696-1704. Akhtar AA, Gowing G, Kobritz N, Savinoff SE, Garcia L, Saxon D, Cho N, Kim G, Tom CM, Park H, Lawless G, Shelley BC, Mattis VB, Breunig JJ, Svendsen CN. PMID: 29706501; PMCID: PMC5989694.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    42. Transplantation of Neural Progenitor Cells Expressing Glial Cell Line-Derived Neurotrophic Factor into the Motor Cortex as a Strategy to Treat Amyotrophic Lateral Sclerosis. Stem Cells. 2018 07; 36(7):1122-1131. Thomsen GM, Avalos P, Ma AA, Alkaslasi M, Cho N, Wyss L, Vit JP, Godoy M, Suezaki P, Shelest O, Bankiewicz KS, Svendsen CN. PMID: 29656478.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    43. Human iPSC-Derived Endothelial Cells and Microengineered Organ-Chip Enhance Neuronal Development. Stem Cell Reports. 2018 04 10; 10(4):1222-1236. Sances S, Ho R, Vatine G, West D, Laperle A, Meyer A, Godoy M, Kay PS, Mandefro B, Hatata S, Hinojosa C, Wen N, Sareen D, Hamilton GA, Svendsen CN. PMID: 29576540; PMCID: PMC5998748.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    44. Huntington modeling improves with age. Nat Neurosci. 2018 03; 21(3):301-303. Mattis VB, Svendsen CN. PMID: 29476127.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    45. Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips. Cell Mol Gastroenterol Hepatol. 2018; 5(4):669-677.e2. Workman MJ, Gleeson JP, Troisi EJ, Estrada HQ, Kerns SJ, Hinojosa CD, Hamilton GA, Targan SR, Svendsen CN, Barrett RJ. PMID: 29930984; PMCID: PMC6009013.
      View in: PubMed   Mentions: 91     Fields:    
    46. The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations. Cell Syst. 2018 01 24; 6(1):13-24. Keenan AB, Jenkins SL, Jagodnik KM, Koplev S, He E, Torre D, Wang Z, Dohlman AB, Silverstein MC, Lachmann A, Kuleshov MV, Ma'ayan A, Stathias V, Terryn R, Cooper D, Forlin M, Koleti A, Vidovic D, Chung C, Schürer SC, Vasiliauskas J, Pilarczyk M, Shamsaei B, Fazel M, Ren Y, Niu W, Clark NA, White S, Mahi N, Zhang L, Kouril M, Reichard JF, Sivaganesan S, Medvedovic M, Meller J, Koch RJ, Birtwistle MR, Iyengar R, Sobie EA, Azeloglu EU, Kaye J, Osterloh J, Haston K, Kalra J, Finkbiener S, Li J, Milani P, Adam M, Escalante-Chong R, Sachs K, Lenail A, Ramamoorthy D, Fraenkel E, Daigle G, Hussain U, Coye A, Rothstein J, Sareen D, Ornelas L, Banuelos M, Mandefro B, Ho R, Svendsen CN, Lim RG, Stocksdale J, Casale MS, Thompson TG, Wu J, Thompson LM, Dardov V, Venkatraman V, Matlock A, Van Eyk JE, Jaffe JD, Papanastasiou M, Subramanian A, Golub TR, Erickson SD, Fallahi-Sichani M, Hafner M, Gray NS, Lin JR, Mills CE, Muhlich JL, Niepel M, Shamu CE, Williams EH, Wrobel D, Sorger PK, Heiser LM, Gray JW, Korkola JE, Mills GB, LaBarge M, Feiler HS, Dane MA, Bucher E, Nederlof M, Sudar D, Gross S, Kilburn DF, Smith R, Devlin K, Margolis R, Derr L, Lee A, Pillai A. PMID: 29199020; PMCID: PMC5799026.
      View in: PubMed   Mentions: 201     Fields:    Translation:HumansCells
    47. A Comparison of mRNA Sequencing with Random Primed and 3'-Directed Libraries. Sci Rep. 2017 11 07; 7(1):14626. Xiong Y, Soumillon M, Wu J, Hansen J, Hu B, van Hasselt JGC, Jayaraman G, Lim R, Bouhaddou M, Ornelas L, Bochicchio J, Lenaeus L, Stocksdale J, Shim J, Gomez E, Sareen D, Svendsen C, Thompson LM, Mahajan M, Iyengar R, Sobie EA, Azeloglu EU, Birtwistle MR. PMID: 29116112; PMCID: PMC5676863.
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    48. Directed Differentiation of Human Induced Pluripotent Stem Cells into Fallopian Tube Epithelium. Sci Rep. 2017 09 06; 7(1):10741. Yucer N, Holzapfel M, Jenkins Vogel T, Lenaeus L, Ornelas L, Laury A, Sareen D, Barrett R, Karlan BY, Svendsen CN. PMID: 28878359; PMCID: PMC5587694.
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    49. Concise Review: Stem Cells for Corneal Wound Healing. Stem Cells. 2017 10; 35(10):2105-2114. Saghizadeh M, Kramerov AA, Svendsen CN, Ljubimov AV. PMID: 28748596; PMCID: PMC5637932.
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    50. Patients with ALS show highly correlated progression rates in left and right limb muscles. Neurology. 2017 Jul 11; 89(2):196-206. Rushton DJ, Andres PL, Allred P, Baloh RH, Svendsen CN. PMID: 28600459; PMCID: PMC5501935.
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    51. Modeling Psychomotor Retardation using iPSCs from MCT8-Deficient Patients Indicates a Prominent Role for the Blood-Brain Barrier. Cell Stem Cell. 2017 06 01; 20(6):831-843.e5. Vatine GD, Al-Ahmad A, Barriga BK, Svendsen S, Salim A, Garcia L, Garcia VJ, Ho R, Yucer N, Qian T, Lim RG, Wu J, Thompson LM, Spivia WR, Chen Z, Van Eyk J, Palecek SP, Refetoff S, Shusta EV, Svendsen CN. PMID: 28526555; PMCID: PMC6659720.
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    52. Huntington's Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits. Cell Rep. 2017 05 16; 19(7):1365-1377. Lim RG, Quan C, Reyes-Ortiz AM, Lutz SE, Kedaigle AJ, Gipson TA, Wu J, Vatine GD, Stocksdale J, Casale MS, Svendsen CN, Fraenkel E, Housman DE, Agalliu D, Thompson LM. PMID: 28514657; PMCID: PMC5646270.
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    53. Human Neural Progenitor Transplantation Rescues Behavior and Reduces α-Synuclein in a Transgenic Model of Dementia with Lewy Bodies. Stem Cells Transl Med. 2017 06; 6(6):1477-1490. Goldberg NRS, Marsh SE, Ochaba J, Shelley BC, Davtyan H, Thompson LM, Steffan JS, Svendsen CN, Blurton-Jones M. PMID: 28225193; PMCID: PMC5464354.
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    56. A model of recurrent concussion that leads to long-term motor deficits, CTE-like tauopathy and exacerbation of an ALS phenotype. J Trauma Acute Care Surg. 2016 12; 81(6):1070-1079. Thomsen GM, Ma AM, Ko A, Harada MY, Wyss L, Haro PS, Vit JP, Shelest O, Rhee P, Svendsen CN, Ley EJ. PMID: 27602892.
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    58. Transcriptome and proteome characterization of surface ectoderm cells differentiated from human iPSCs. Sci Rep. 2016 08 23; 6:32007. Qu Y, Zhou B, Yang W, Han B, Yu-Rice Y, Gao B, Johnson J, Svendsen CN, Freeman MR, Giuliano AE, Sareen D, Cui X. PMID: 27550649; PMCID: PMC4994084.
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    59. ALS disrupts spinal motor neuron maturation and aging pathways within gene co-expression networks. Nat Neurosci. 2016 09; 19(9):1256-67. Ho R, Sances S, Gowing G, Amoroso MW, O'Rourke JG, Sahabian A, Wichterle H, Baloh RH, Sareen D, Svendsen CN. PMID: 27428653; PMCID: PMC5003654.
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    60. Cell freezing protocol suitable for ATAC-Seq on motor neurons derived from human induced pluripotent stem cells. Sci Rep. 2016 05 05; 6:25474. Milani P, Escalante-Chong R, Shelley BC, Patel-Murray NL, Xin X, Adam M, Mandefro B, Sareen D, Svendsen CN, Fraenkel E. PMID: 27146274; PMCID: PMC4857123.
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    61. Modeling ALS with motor neurons derived from human induced pluripotent stem cells. Nat Neurosci. 2016 Apr; 19(4):542-53. Sances S, Bruijn LI, Chandran S, Eggan K, Ho R, Klim JR, Livesey MR, Lowry E, Macklis JD, Rushton D, Sadegh C, Sareen D, Wichterle H, Zhang SC, Svendsen CN. PMID: 27021939; PMCID: PMC5015775.
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    62. Human neural progenitors differentiate into astrocytes and protect motor neurons in aging rats. Exp Neurol. 2016 06; 280:41-9. Das MM, Avalos P, Suezaki P, Godoy M, Garcia L, Chang CD, Vit JP, Shelley B, Gowing G, Svendsen CN. PMID: 27032721.
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    63. In Vivo CRISPR/Cas9 Gene Editing Corrects Retinal Dystrophy in the S334ter-3 Rat Model of Autosomal Dominant Retinitis Pigmentosa. Mol Ther. 2016 Mar; 24(3):556-63. Bakondi B, Lv W, Lu B, Jones MK, Tsai Y, Kim KJ, Levy R, Akhtar AA, Breunig JJ, Svendsen CN, Wang S. PMID: 26666451; PMCID: PMC4786918.
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    64. Modeling Huntington׳s disease with patient-derived neurons. Brain Res. 2017 02 01; 1656:76-87. Mattis VB, Svendsen CN. PMID: 26459990.
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    65. Preclinical Validation of Multilevel Intraparenchymal Stem Cell Therapy in the Porcine Spinal Cord. Neurosurgery. 2015 Oct; 77(4):604-12; discussion 612. Gutierrez J, Lamanna JJ, Grin N, Hurtig CV, Miller JH, Riley J, Urquia L, Avalos P, Svendsen CN, Federici T, Boulis NM. PMID: 26134596.
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    66. Quantitative high-throughput gene expression profiling of human striatal development to screen stem cell-derived medium spiny neurons. Mol Ther Methods Clin Dev. 2015; 2:15030. Straccia M, Garcia-Diaz Barriga G, Sanders P, Bombau G, Carrere J, Mairal PB, Vinh NN, Yung S, Kelly CM, Svendsen CN, Kemp PJ, Arjomand J, Schoenfeld RC, Alberch J, Allen ND, Rosser AE, Canals JM. PMID: 26417608; PMCID: PMC4571731.
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    68. In Vivo Tracking of Human Neural Progenitor Cells in the Rat Brain Using Magnetic Resonance Imaging Is Not Enhanced by Ferritin Expression. Cell Transplant. 2016; 25(3):575-92. Bernau K, Lewis CM, Petelinsek AM, Reagan MS, Niles DJ, Mattis VB, Meyerand ME, Suzuki M, Svendsen CN. PMID: 26160767; PMCID: PMC5052815.
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    69. Acute Traumatic Brain Injury Does Not Exacerbate Amyotrophic Lateral Sclerosis in the SOD1 (G93A) Rat Model eNeuro. 2015 May-Jun; 2(3). Thomsen GM, Vit JP, Lamb A, Gowing G, Shelest O, Alkaslasi M, Ley EJ, Svendsen CN. PMID: 26464984; PMCID: PMC4586929.
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    71. HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity. Hum Mol Genet. 2015 Jun 01; 24(11):3257-71. Mattis VB, Tom C, Akimov S, Saeedian J, Østergaard ME, Southwell AL, Doty CN, Ornelas L, Sahabian A, Lenaeus L, Mandefro B, Sareen D, Arjomand J, Hayden MR, Ross CA, Svendsen CN. PMID: 25740845; PMCID: PMC4424959.
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    73. Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease. Sci Transl Med. 2014 Dec 24; 6(268):268ra178. Lu XH, Mattis VB, Wang N, Al-Ramahi I, van den Berg N, Fratantoni SA, Waldvogel H, Greiner E, Osmand A, Elzein K, Xiao J, Dijkstra S, de Pril R, Vinters HV, Faull R, Signer E, Kwak S, Marugan JJ, Botas J, Fischer DF, Svendsen CN, Munoz-Sanjuan I, Yang XW. PMID: 25540325.
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    74. Delayed disease onset and extended survival in the SOD1G93A rat model of amyotrophic lateral sclerosis after suppression of mutant SOD1 in the motor cortex. J Neurosci. 2014 Nov 19; 34(47):15587-600. Thomsen GM, Gowing G, Latter J, Chen M, Vit JP, Staggenborg K, Avalos P, Alkaslasi M, Ferraiuolo L, Likhite S, Kaspar BK, Svendsen CN. PMID: 25411487; PMCID: PMC4298650.
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    75. Reliable generation of induced pluripotent stem cells from human lymphoblastoid cell lines. Stem Cells Transl Med. 2014 Dec; 3(12):1429-34. Barrett R, Ornelas L, Yeager N, Mandefro B, Sahabian A, Lenaeus L, Targan SR, Svendsen CN, Sareen D. PMID: 25298370; PMCID: PMC4250214.
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    76. Astrocytes show reduced support of motor neurons with aging that is accelerated in a rodent model of ALS. Neurobiol Aging. 2015 Feb; 36(2):1130-9. Das MM, Svendsen CN. PMID: 25443290.
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    77. Differentiation of human limbal-derived induced pluripotent stem cells into limbal-like epithelium. Stem Cells Transl Med. 2014 Sep; 3(9):1002-12. Sareen D, Saghizadeh M, Ornelas L, Winkler MA, Narwani K, Sahabian A, Funari VA, Tang J, Spurka L, Punj V, Maguen E, Rabinowitz YS, Svendsen CN, Ljubimov AV. PMID: 25069777; PMCID: PMC4149305.
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    78. A cGMP-applicable expansion method for aggregates of human neural stem and progenitor cells derived from pluripotent stem cells or fetal brain tissue. J Vis Exp. 2014 Jun 15; (88). Shelley BC, Gowing G, Svendsen CN. PMID: 24962813; PMCID: PMC4195512.
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    79. Glial cell line-derived neurotrophic factor-secreting human neural progenitors show long-term survival, maturation into astrocytes, and no tumor formation following transplantation into the spinal cord of immunocompromised rats. Neuroreport. 2014 Apr 16; 25(6):367-72. Gowing G, Shelley B, Staggenborg K, Hurley A, Avalos P, Victoroff J, Latter J, Garcia L, Svendsen CN. PMID: 24284956; PMCID: PMC3969154.
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    80. Human induced pluripotent stem cells are a novel source of neural progenitor cells (iNPCs) that migrate and integrate in the rodent spinal cord. J Comp Neurol. 2014 Aug 15; 522(12):2707-28. Sareen D, Gowing G, Sahabian A, Staggenborg K, Paradis R, Avalos P, Latter J, Ornelas L, Garcia L, Svendsen CN. PMID: 24610630; PMCID: PMC4070510.
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    81. Patient-derived skeletal dysplasia induced pluripotent stem cells display abnormal chondrogenic marker expression and regulation by BMP2 and TGFβ1. Stem Cells Dev. 2014 Jul 01; 23(13):1464-78. Saitta B, Passarini J, Sareen D, Ornelas L, Sahabian A, Argade S, Krakow D, Cohn DH, Svendsen CN, Rimoin DL. PMID: 24559391; PMCID: PMC4066255.
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    82. The past, present and future of stem cell clinical trials for ALS. Exp Neurol. 2014 Dec; 262 Pt B:127-37. Thomsen GM, Gowing G, Svendsen S, Svendsen CN. PMID: 24613827.
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    83. Sca1⁺ murine pituitary adenoma cells show tumor-growth advantage. Endocr Relat Cancer. 2014 Apr; 21(2):203-16. Donangelo I, Ren SG, Eigler T, Svendsen C, Melmed S. PMID: 24481638; PMCID: PMC3978815.
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    84. Ocular changes in TgF344-AD rat model of Alzheimer's disease. Invest Ophthalmol Vis Sci. 2014 Jan 29; 55(1):523-34. Tsai Y, Lu B, Ljubimov AV, Girman S, Ross-Cisneros FN, Sadun AA, Svendsen CN, Cohen RM, Wang S. PMID: 24398104; PMCID: PMC3907137.
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    85. Neonatal immune-tolerance in mice does not prevent xenograft rejection. Exp Neurol. 2014 Apr; 254:90-8. Mattis VB, Wakeman DR, Tom C, Dodiya HB, Yeung SY, Tran AH, Bernau K, Ornelas L, Sahabian A, Reidling J, Sareen D, Thompson LM, Kordower JH, Svendsen CN. PMID: 24440640; PMCID: PMC3954854.
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    86. Stimulation of GABA-induced Ca2+ influx enhances maturation of human induced pluripotent stem cell-derived neurons. PLoS One. 2013; 8(11):e81031. Rushton DJ, Mattis VB, Svendsen CN, Allen ND, Kemp PJ. PMID: 24278369; PMCID: PMC3838360.
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    87. A simple alkaline method for decellularizing human amniotic membrane for cell culture. PLoS One. 2013; 8(11):e79632. Saghizadeh M, Winkler MA, Kramerov AA, Hemmati DM, Ghiam CA, Dimitrijevich SD, Sareen D, Ornelas L, Ghiasi H, Brunken WJ, Maguen E, Rabinowitz YS, Svendsen CN, Jirsova K, Ljubimov AV. PMID: 24236148; PMCID: PMC3827346.
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    88. Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion. Sci Transl Med. 2013 Oct 23; 5(208):208ra149. Sareen D, O'Rourke JG, Meera P, Muhammad AK, Grant S, Simpkinson M, Bell S, Carmona S, Ornelas L, Sahabian A, Gendron T, Petrucelli L, Baughn M, Ravits J, Harms MB, Rigo F, Bennett CF, Otis TS, Svendsen CN, Baloh RH. PMID: 24154603; PMCID: PMC4090945.
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    89. Back to the future: how human induced pluripotent stem cells will transform regenerative medicine. Hum Mol Genet. 2013 Oct 15; 22(R1):R32-8. Svendsen CN. PMID: 23945396; PMCID: PMC3782070.
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    90. Synergistic effects of GDNF and VEGF on lifespan and disease progression in a familial ALS rat model. Mol Ther. 2013 Aug; 21(8):1602-10. Krakora D, Mulcrone P, Meyer M, Lewis C, Bernau K, Gowing G, Zimprich C, Aebischer P, Svendsen CN, Suzuki M. PMID: 23712039; PMCID: PMC3734670.
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    91. EZ spheres: a stable and expandable culture system for the generation of pre-rosette multipotent stem cells from human ESCs and iPSCs. Stem Cell Res. 2013 May; 10(3):417-427. Ebert AD, Shelley BC, Hurley AM, Onorati M, Castiglioni V, Patitucci TN, Svendsen SP, Mattis VB, McGivern JV, Schwab AJ, Sareen D, Kim HW, Cattaneo E, Svendsen CN. PMID: 23474892; PMCID: PMC3786426.
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    92. Neural Stem Cells Derived by Small Molecules Preserve Vision. Transl Vis Sci Technol. 2013 Jan; 2(1):1. Lu B, Morgans CW, Girman S, Luo J, Zhao J, Du H, Lim S, Ding S, Svendsen C, Zhang K, Wang S. PMID: 24049711; PMCID: PMC3763886.
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    94. Rapid genetic targeting of pial surface neural progenitors and immature neurons by neonatal electroporation. Neural Dev. 2012 Jul 10; 7:26. Breunig JJ, Gate D, Levy R, Rodriguez J, Kim GB, Danielpour M, Svendsen CN, Town T. PMID: 22776033; PMCID: PMC3479020.
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