Lali K Medina-Kauwe

Title(s)Professor-in-Residence, Medicine
SchoolMedicine
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    Corrole nanobiologics for targeting resistant and metastatic tumors
    NIH R01CA140995Jul 1, 2009 - Aug 31, 2022
    Role: Principal Investigator
    Protein-DNA Drug Carriers for Targeting Drug-Resistant Tumors
    NIH R01CA129822Jul 1, 2007 - Jul 31, 2021
    Role: Principal Investigator
    A NOVEL TARGETED THERAPEUTIC USING VIRAL CAPSID PROTEIN
    NIH R21CA116014Apr 10, 2007 - Mar 31, 2010
    Role: Principal Investigator
    Heregulin-Targeted Protein Uptake for Breast Cancer
    NIH R01CA102126Sep 2, 2003 - Aug 31, 2009
    Role: Principal Investigator
    TPO PLATELET INDUCTION--GENE EXPRESSION, GENE THERAPY
    NIH F32HL009638Mar 18, 1997
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Adenovirus-Derived Nano-Capsid Platforms for Targeted Delivery and Penetration of Macromolecules into Resistant and Metastatic Tumors. Cancers (Basel). 2023 Jun 19; 15(12). Benhaghnazar RL, Medina-Kauwe L. PMID: 37370850; PMCID: PMC10296971.
      View in: PubMed   Mentions:
    2. Novel potent azetidine-based compounds irreversibly inhibit Stat3 activation and induce antitumor response against human breast tumor growth in vivo. Cancer Lett. 2022 05 28; 534:215613. Yue P, Zhu Y, Brotherton-Pleiss C, Fu W, Verma N, Chen J, Nakamura K, Chen W, Chen Y, Alonso-Valenteen F, Mikhael S, Medina-Kauwe L, Kershaw KM, Celeridad M, Pan S, Limpert AS, Sheffler DJ, Cosford NDP, Shiao SL, Tius MA, Lopez-Tapia F, Turkson J. PMID: 35276290; PMCID: PMC9867837.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    3. A chemokine regulatory loop induces cholesterol synthesis in lung-colonizing triple-negative breast cancer cells to fuel metastatic growth. Mol Ther. 2022 02 02; 30(2):672-687. Han B, Alonso-Valenteen F, Wang Z, Deng N, Lee TY, Gao B, Zhang Y, Xu Y, Zhang X, Billet S, Fan X, Shiao S, Bhowmick N, Medina-Kauwe L, Giuliano A, Cui X. PMID: 34274535; PMCID: PMC8821896.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    4. Discovery of Novel Azetidine Amides as Potent Small-Molecule STAT3 Inhibitors. J Med Chem. 2021 01 14; 64(1):695-710. Brotherton-Pleiss C, Yue P, Zhu Y, Nakamura K, Chen W, Fu W, Kubota C, Chen J, Alonso-Valenteen F, Mikhael S, Medina-Kauwe L, Tius MA, Lopez-Tapia F, Turkson J. PMID: 33352047; PMCID: PMC7816766.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    5. Syndecan-1 promotes lung fibrosis by regulating epithelial reprogramming through extracellular vesicles. JCI Insight. 2019 08 08; 5. Parimon T, Yao C, Habiel DM, Ge L, Bora SA, Brauer R, Evans CM, Xie T, Alonso-Valenteen F, Medina-Kauwe LK, Jiang D, Noble PW, Hogaboam CM, Deng N, Burgy O, Antes TJ, Königshoff M, Stripp BR, Gharib SA, Chen P. PMID: 31393853; PMCID: PMC6777916.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    6. Knob protein enhances epithelial barrier integrity and attenuates airway inflammation. J Allergy Clin Immunol. 2018 12; 142(6):1808-1817.e3. Ha SG, Dileepan M, Ge XN, Kang BN, Greenberg YG, Rao A, Muralidhar G, Medina-Kauwe L, Thompson MA, Pabelick CM, O'Grady SM, Rao SP, Sriramarao P. PMID: 29522849; PMCID: PMC6126992.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    7. Resistance to receptor-blocking therapies primes tumors as targets for HER3-homing nanobiologics. J Control Release. 2018 02 10; 271:127-138. Sims JD, Taguiam JM, Alonso-Valenteen F, Markman J, Agadjanian H, Chu D, Lubow J, Abrol R, Srinivas D, Jain A, Han B, Qu Y, Mirzadehgan P, Hwang JY, Rentsendorj A, Chung A, Lester J, Karlan BY, Gray HB, Gross Z, Giuliano A, Cui X, Medina-Kauwe LK. PMID: 29288681; PMCID: PMC5807213.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    8. A corrole nanobiologic elicits tissue-activated MRI contrast enhancement and tumor-targeted toxicity. J Control Release. 2015 Nov 10; 217:92-101. Sims JD, Hwang JY, Wagner S, Alonso-Valenteen F, Hanson C, Taguiam JM, Polo R, Harutyunyan I, Karapetyan G, Sorasaenee K, Ibrahim A, Marban E, Moats R, Gray HB, Gross Z, Medina-Kauwe LK. PMID: 26334483; PMCID: PMC4623877.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    9. Basal Protein Expression Is Associated With Worse Outcome and Trastuzamab Resistance in HER2+ Invasive Breast Cancer. Clin Breast Cancer. 2015 Dec; 15(6):448-457.e2. Chung A, Choi M, Han BC, Bose S, Zhang X, Medina-Kauwe L, Sims J, Murali R, Taguiam M, Varda M, Schiff R, Giuliano A, Cui X. PMID: 26248960; PMCID: PMC4644726.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    10. Cellular uptake and cytotoxicity of a near-IR fluorescent corrole-TiO2 nanoconjugate. J Inorg Biochem. 2014 Nov; 140:39-44. Blumenfeld CM, Sadtler BF, Fernandez GE, Dara L, Nguyen C, Alonso-Valenteen F, Medina-Kauwe L, Moats RA, Lewis NS, Grubbs RH, Gray HB, Sorasaenee K. PMID: 25061689; PMCID: PMC4998051.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    11. Analysis of targeted viral protein nanoparticles delivered to HER2+ tumors. J Vis Exp. 2013 Jun 18; (76). Hwang JY, Farkas DL, Medina-Kauwe LK. PMID: 23851334; PMCID: PMC3727523.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    12. Development of adenovirus capsid proteins for targeted therapeutic delivery. Ther Deliv. 2013 Feb; 4(2):267-77. Medina-Kauwe LK. PMID: 23343164; PMCID: PMC3645976.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    13. Photoexcitation of tumor-targeted corroles induces singlet oxygen-mediated augmentation of cytotoxicity. J Control Release. 2012 Nov 10; 163(3):368-73. Hwang JY, Lubow DJ, Chu D, Sims J, Alonso-Valenteen F, Gray HB, Gross Z, Farkas DL, Medina-Kauwe LK. PMID: 23041277; PMCID: PMC3498762.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    14. A multimode optical imaging system for preclinical applications in vivo: technology development, multiscale imaging, and chemotherapy assessment. Mol Imaging Biol. 2012 Aug; 14(4):431-42. Hwang JY, Wachsmann-Hogiu S, Ramanujan VK, Ljubimova J, Gross Z, Gray HB, Medina-Kauwe LK, Farkas DL. PMID: 21874388; PMCID: PMC3487699.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    15. Multimodality imaging in vivo for preclinical assessment of tumor-targeted doxorubicin nanoparticles. PLoS One. 2012; 7(4):e34463. Hwang JY, Park J, Kang BJ, Lubow DJ, Chu D, Farkas DL, Shung KK, Medina-Kauwe LK. PMID: 22509306; PMCID: PMC3317981.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    16. Fluorescence response of human HER2+ cancer- and MCF-12F normal cells to 200MHz ultrasound microbeam stimulation: a preliminary study of membrane permeability variation. Ultrasonics. 2012 Sep; 52(7):803-8. Hwang JY, Lee J, Lee C, Jakob A, Lemor R, Medina-Kauwe LK, Shung KK. PMID: 22513260; PMCID: PMC3392461.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    17. Chemotherapy targeting by DNA capture in viral protein particles. Nanomedicine (Lond). 2012 Mar; 7(3):335-52. Agadjanian H, Chu D, Hwang JY, Wachsmann-Hogiu S, Rentsendorj A, Song L, Valluripalli V, Lubow J, Ma J, Sharifi B, Farkas DL, Medina-Kauwe LK. PMID: 22385197; PMCID: PMC3429352.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    18. Investigating photoexcitation-induced mitochondrial damage by chemotherapeutic corroles using multimode optical imaging. J Biomed Opt. 2012 Jan; 17(1):015003. Hwang JY, Lubow DJ, Sims JD, Gray HB, Mahammed A, Gross Z, Medina-Kauwe LK, Farkas DL. PMID: 22352647; PMCID: PMC3380813.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    19. A mechanistic study of tumor-targeted corrole toxicity. Mol Pharm. 2011 Dec 05; 8(6):2233-43. Hwang JY, Lubow J, Chu D, Ma J, Agadjanian H, Sims J, Gray HB, Gross Z, Farkas DL, Medina-Kauwe LK. PMID: 21981771; PMCID: PMC3230680.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    20. Ratiometric spectral imaging for fast tumor detection and chemotherapy monitoring in vivo. J Biomed Opt. 2011 Jun; 16(6):066007. Hwang JY, Gross Z, Gray HB, Medina-Kauwe LK, Farkas DL. PMID: 21721808; PMCID: PMC3133799.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    21. Multimode Optical Imaging for Translational Chemotherapy: In Vivo Tumor Detection and Delineation by Targeted Gallium Corroles. Proc SPIE Int Soc Opt Eng. 2011 Feb 28; 7902. Hwang JY, Gross Z, Gray HB, Medina-Kauwe LK, Farkas DL. PMID: 26412924; PMCID: PMC4582672.
      View in: PubMed   Mentions: 2  
    22. Investigating the photosensitizer-potential of targeted gallium corrole using multimode optical imaging. Proc SPIE Int Soc Opt Eng. 2011 Jan 22; 7886. Hwang JY, Lubow J, Chu D, Gross Z, Gray HB, Farkas DL, Medina-Kauwe LK. PMID: 26028799; PMCID: PMC4445411.
      View in: PubMed   Mentions: 2  
    23. Multimodal wide-field two-photon excitation imaging: characterization of the technique for in vivo applications. Biomed Opt Express. 2011 Jan 13; 2(2):356-64. Hwang JY, Wachsmann-Hogiu S, Ramanujan VK, Nowatzyk AG, Koronyo Y, Medina-Kauwe LK, Gross Z, Gray HB, Farkas DL. PMID: 21339880; PMCID: PMC3038450.
      View in: PubMed   Mentions: 11  
    24. Tumor detection and elimination by a targeted gallium corrole. Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6105-10. Agadjanian H, Ma J, Rentsendorj A, Valluripalli V, Hwang JY, Mahammed A, Farkas DL, Gray HB, Gross Z, Medina-Kauwe LK. PMID: 19342490; PMCID: PMC2669340.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    25. Large Field of View Scanning Fluorescence Lifetime Imaging System for Multimode Optical Imaging of Small Animals. Proc SPIE Int Soc Opt Eng. 2008 Mar; 6859. Hwang JY, Agadjanian H, Medina-Kauwe LK, Gross Z, Gray HB, Sorasaenee K, Farkas DL. PMID: 29386697; PMCID: PMC5788201.
      View in: PubMed   Mentions: 4  
    26. Corroles that bind with high affinity to both apo and holo transferrin. J Inorg Biochem. 2008 Mar; 102(3):446-57. Haber A, Agadjanian H, Medina-Kauwe LK, Gross Z. PMID: 18180041.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    27. "Alternative" endocytic mechanisms exploited by pathogens: new avenues for therapeutic delivery? Adv Drug Deliv Rev. 2007 Aug 10; 59(8):798-809. Medina-Kauwe LK. PMID: 17707545; PMCID: PMC2040389.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    28. Novel fiber-dependent entry mechanism for adenovirus serotype 5 in lacrimal acini. J Virol. 2006 Dec; 80(23):11833-51. Xie J, Chiang L, Contreras J, Wu K, Garner JA, Medina-Kauwe L, Hamm-Alvarez SF. PMID: 16987972; PMCID: PMC1642591.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    29. Effective high-capacity gutless adenoviral vectors mediate transgene expression in human glioma cells. Mol Ther. 2006 Sep; 14(3):371-81. Candolfi M, Curtin JF, Xiong WD, Kroeger KM, Liu C, Rentsendorj A, Agadjanian H, Medina-Kauwe L, Palmer D, Ng P, Lowenstein PR, Castro MG. PMID: 16798098; PMCID: PMC1629029.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    30. Typical and atypical trafficking pathways of Ad5 penton base recombinant protein: implications for gene transfer. Gene Ther. 2006 May; 13(10):821-36. Rentsendorj A, Xie J, MacVeigh M, Agadjanian H, Bass S, Kim DH, Rossi J, Hamm-Alvarez SF, Medina-Kauwe LK. PMID: 16482205.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    31. Specific delivery of corroles to cells via noncovalent conjugates with viral proteins. Pharm Res. 2006 Feb; 23(2):367-77. Agadjanian H, Weaver JJ, Mahammed A, Rentsendorj A, Bass S, Kim J, Dmochowski IJ, Margalit R, Gray HB, Gross Z, Medina-Kauwe LK. PMID: 16411149.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    32. Regulatable gutless adenovirus vectors sustain inducible transgene expression in the brain in the presence of an immune response against adenoviruses. J Virol. 2006 Jan; 80(1):27-37. Xiong W, Goverdhana S, Sciascia SA, Candolfi M, Zirger JM, Barcia C, Curtin JF, King GD, Jaita G, Liu C, Kroeger K, Agadjanian H, Medina-Kauwe L, Palmer D, Ng P, Lowenstein PR, Castro MG. PMID: 16352528; PMCID: PMC1317549.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    33. Intracellular trafficking of nonviral vectors. Gene Ther. 2005 Dec; 12(24):1734-51. Medina-Kauwe LK, Xie J, Hamm-Alvarez S. PMID: 16079885.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    34. Introduction to the special issue: traveling the intracellular highway to gene therapy. Gene Ther. 2005 Jun; 12(11):863-4. Medina-Kauwe LK. PMID: 15908993.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    35. The Ad5 fiber mediates nonviral gene transfer in the absence of the whole virus, utilizing a novel cell entry pathway. Gene Ther. 2005 Feb; 12(3):225-37. Rentsendorj A, Agadjanian H, Chen X, Cirivello M, Macveigh M, Kedes L, Hamm-Alvarez S, Medina-Kauwe LK. PMID: 15483666.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    36. Adenoviral capsid modulates secretory compartment organization and function in acinar epithelial cells from rabbit lacrimal gland. Gene Ther. 2004 Jun; 11(12):970-81. Wang Y, Xie J, Yarber FA, Mazurek C, Trousdale MD, Medina-Kauwe LK, Kasahara N, Hamm-Alvarez SF. PMID: 15029229.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    37. Modulation of secretory functions in epithelia by adenovirus capsid proteins. J Control Release. 2003 Dec 05; 93(2):129-40. Hamm-Alvarez SF, Xie J, Wang Y, Medina-Kauwe LK. PMID: 14636719.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    38. Endocytosis of adenovirus and adenovirus capsid proteins. Adv Drug Deliv Rev. 2003 Nov 14; 55(11):1485-96. Medina-Kauwe LK. PMID: 14597142.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    39. Using GFP--ligand fusions to measure receptor-mediated endocytosis in living cells. Vitam Horm. 2002; 65:81-95. Medina-Kauwe LK, Chen X. PMID: 12481543.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    40. Nonviral gene delivery to human breast cancer cells by targeted Ad5 penton proteins. Gene Ther. 2001 Dec; 8(23):1753-61. Medina-Kauwe LK, Maguire M, Kasahara N, Kedes L. PMID: 11803394.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    41. 3PO, a novel nonviral gene delivery system using engineered Ad5 penton proteins. Gene Ther. 2001 May; 8(10):795-803. Medina-Kauwe LK, Kasahara N, Kedes L. PMID: 11420644.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    42. Assessing the binding and endocytosis activity of cellular receptors using GFP-ligand fusions. Biotechniques. 2000 Sep; 29(3):602-4, 606-8, 609. Medina-Kauwe LK, Leung V, Wu L, Kedes L. PMID: 10997274.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    43. 4-Aminobutyrate aminotransferase (GABA-transaminase) deficiency. J Inherit Metab Dis. 1999 Jun; 22(4):414-27. Medina-Kauwe LK, Tobin AJ, De Meirleir L, Jaeken J, Jakobs C, Nyhan WL, Gibson KM. PMID: 10407778.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    44. Identification of a familial mutation associated with GABA-transaminase deficiency disease. Neurobiol Dis. 1998 Aug; 5(2):89-96. Medina-Kauwe LK, Nyhan WL, Gibson KM, Tobin AJ. PMID: 9746906.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    45. gamma-Aminobutyric acid (GABA) metabolism in mammalian neural and nonneural tissues. Comp Biochem Physiol A Physiol. 1995 Oct; 112(2):247-63. Tillakaratne NJ, Medina-Kauwe L, Gibson KM. PMID: 7584821.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimals
    46. A rat brain cDNA encodes enzymatically active GABA transaminase and provides a molecular probe for GABA-catabolizing cells. J Neurochem. 1994 Apr; 62(4):1267-75. Medina-Kauwe LK, Tillakaratne NJ, Wu JY, Tobin AJ. PMID: 8133261.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
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