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Lali K Medina-Kauwe

Title(s)Professor-in-Residence, Medicine
SchoolMedicine
Phone(310) 423-7339
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    Collapse Research 
    Collapse Research Activities and Funding
    Corrole nanobiologics for targeting resistant and metastatic tumors
    NIH/NCI R01CA140995Feb 5, 2010 - Dec 31, 2014
    Role: Principal Investigator
    Protein-DNA Drug Carriers for Targeting Drug-Resistant Tumors
    NIH/NCI R01CA129822Jul 1, 2007 - Jul 31, 2021
    Role: Principal Investigator
    A NOVEL TARGETED THERAPEUTIC USING VIRAL CAPSID PROTEIN
    NIH/NCI R21CA116014Apr 10, 2007 - Mar 31, 2010
    Role: Principal Investigator
    Heregulin-Targeted Protein Uptake for Breast Cancer
    NIH/NCI R01CA102126Sep 2, 2003 - Aug 31, 2009
    Role: Principal Investigator
    TPO PLATELET INDUCTION--GENE EXPRESSION, GENE THERAPY
    NIH/NHLBI F32HL009638Mar 18, 1997
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Parimon T, Yao C, Habiel DM, Ge L, Bora SA, Brauer R, Evans CM, Xie T, Alonso-Valenteen F, Medina-Kauwe LK, Jiang D, Noble PW, Hogaboam CM, Deng N, Burgy O, Antes TJ, Königshoff M, Stripp BR, Gharib SA, Chen P. Syndecan-1 promotes lung fibrosis by regulating epithelial reprogramming through extracellular vesicles. JCI Insight. 2019 Aug 08; 5. PMID: 31393853.
      View in: PubMed
    2. Ha SG, Dileepan M, Ge XN, Kang BN, Greenberg YG, Rao A, Muralidhar G, Medina-Kauwe L, Thompson MA, Pabelick CM, O'Grady SM, Rao SP, Sriramarao P. Knob protein enhances epithelial barrier integrity and attenuates airway inflammation. J Allergy Clin Immunol. 2018 12; 142(6):1808-1817.e3. PMID: 29522849.
      View in: PubMed
    3. Sims JD, Taguiam JM, Alonso-Valenteen F, Markman J, Agadjanian H, Chu D, Lubow J, Abrol R, Srinivas D, Jain A, Han B, Qu Y, Mirzadehgan P, Hwang JY, Rentsendorj A, Chung A, Lester J, Karlan BY, Gray HB, Gross Z, Giuliano A, Cui X, Medina-Kauwe LK. Resistance to receptor-blocking therapies primes tumors as targets for HER3-homing nanobiologics. J Control Release. 2018 02 10; 271:127-138. PMID: 29288681.
      View in: PubMed
    4. Sims JD, Hwang JY, Wagner S, Alonso-Valenteen F, Hanson C, Taguiam JM, Polo R, Harutyunyan I, Karapetyan G, Sorasaenee K, Ibrahim A, Marban E, Moats R, Gray HB, Gross Z, Medina-Kauwe LK. A corrole nanobiologic elicits tissue-activated MRI contrast enhancement and tumor-targeted toxicity. J Control Release. 2015 Nov 10; 217:92-101. PMID: 26334483.
      View in: PubMed
    5. Chung A, Choi M, Han BC, Bose S, Zhang X, Medina-Kauwe L, Sims J, Murali R, Taguiam M, Varda M, Schiff R, Giuliano A, Cui X. Basal Protein Expression Is Associated With Worse Outcome and Trastuzamab Resistance in HER2+ Invasive Breast Cancer. Clin Breast Cancer. 2015 Dec; 15(6):448-457.e2. PMID: 26248960.
      View in: PubMed
    6. Blumenfeld CM, Sadtler BF, Fernandez GE, Dara L, Nguyen C, Alonso-Valenteen F, Medina-Kauwe L, Moats RA, Lewis NS, Grubbs RH, Gray HB, Sorasaenee K. Cellular uptake and cytotoxicity of a near-IR fluorescent corrole-TiO2 nanoconjugate. J Inorg Biochem. 2014 Nov; 140:39-44. PMID: 25061689.
      View in: PubMed
    7. Hwang JY, Farkas DL, Medina-Kauwe LK. Analysis of targeted viral protein nanoparticles delivered to HER2+ tumors. J Vis Exp. 2013 Jun 18; (76). PMID: 23851334.
      View in: PubMed
    8. Medina-Kauwe LK. Development of adenovirus capsid proteins for targeted therapeutic delivery. Ther Deliv. 2013 Feb; 4(2):267-77. PMID: 23343164.
      View in: PubMed
    9. Hwang JY, Lubow DJ, Chu D, Sims J, Alonso-Valenteen F, Gray HB, Gross Z, Farkas DL, Medina-Kauwe LK. Photoexcitation of tumor-targeted corroles induces singlet oxygen-mediated augmentation of cytotoxicity. J Control Release. 2012 Nov 10; 163(3):368-73. PMID: 23041277.
      View in: PubMed
    10. Hwang JY, Wachsmann-Hogiu S, Ramanujan VK, Ljubimova J, Gross Z, Gray HB, Medina-Kauwe LK, Farkas DL. A multimode optical imaging system for preclinical applications in vivo: technology development, multiscale imaging, and chemotherapy assessment. Mol Imaging Biol. 2012 Aug; 14(4):431-42. PMID: 21874388.
      View in: PubMed
    11. Hwang JY, Park J, Kang BJ, Lubow DJ, Chu D, Farkas DL, Shung KK, Medina-Kauwe LK. Multimodality imaging in vivo for preclinical assessment of tumor-targeted doxorubicin nanoparticles. PLoS One. 2012; 7(4):e34463. PMID: 22509306.
      View in: PubMed
    12. Hwang JY, Lee J, Lee C, Jakob A, Lemor R, Medina-Kauwe LK, Shung KK. Fluorescence response of human HER2+ cancer- and MCF-12F normal cells to 200MHz ultrasound microbeam stimulation: a preliminary study of membrane permeability variation. Ultrasonics. 2012 Sep; 52(7):803-8. PMID: 22513260.
      View in: PubMed
    13. Agadjanian H, Chu D, Hwang JY, Wachsmann-Hogiu S, Rentsendorj A, Song L, Valluripalli V, Lubow J, Ma J, Sharifi B, Farkas DL, Medina-Kauwe LK. Chemotherapy targeting by DNA capture in viral protein particles. Nanomedicine (Lond). 2012 Mar; 7(3):335-52. PMID: 22385197.
      View in: PubMed
    14. Hwang JY, Lubow DJ, Sims JD, Gray HB, Mahammed A, Gross Z, Medina-Kauwe LK, Farkas DL. Investigating photoexcitation-induced mitochondrial damage by chemotherapeutic corroles using multimode optical imaging. J Biomed Opt. 2012 Jan; 17(1):015003. PMID: 22352647.
      View in: PubMed
    15. Hwang JY, Lubow J, Chu D, Ma J, Agadjanian H, Sims J, Gray HB, Gross Z, Farkas DL, Medina-Kauwe LK. A mechanistic study of tumor-targeted corrole toxicity. Mol Pharm. 2011 Dec 05; 8(6):2233-43. PMID: 21981771.
      View in: PubMed
    16. Hwang JY, Gross Z, Gray HB, Medina-Kauwe LK, Farkas DL. Ratiometric spectral imaging for fast tumor detection and chemotherapy monitoring in vivo. J Biomed Opt. 2011 Jun; 16(6):066007. PMID: 21721808.
      View in: PubMed
    17. Hwang JY, Gross Z, Gray HB, Medina-Kauwe LK, Farkas DL. Multimode Optical Imaging for Translational Chemotherapy: In Vivo Tumor Detection and Delineation by Targeted Gallium Corroles. Proc SPIE Int Soc Opt Eng. 2011 Feb 28; 7902. PMID: 26412924.
      View in: PubMed
    18. Hwang JY, Lubow J, Chu D, Gross Z, Gray HB, Farkas DL, Medina-Kauwe LK. Investigating the photosensitizer-potential of targeted gallium corrole using multimode optical imaging. Proc SPIE Int Soc Opt Eng. 2011 Jan 22; 7886. PMID: 26028799.
      View in: PubMed
    19. Hwang JY, Wachsmann-Hogiu S, Ramanujan VK, Nowatzyk AG, Koronyo Y, Medina-Kauwe LK, Gross Z, Gray HB, Farkas DL. Multimodal wide-field two-photon excitation imaging: characterization of the technique for in vivo applications. Biomed Opt Express. 2011 Jan 13; 2(2):356-64. PMID: 21339880.
      View in: PubMed
    20. Agadjanian H, Ma J, Rentsendorj A, Valluripalli V, Hwang JY, Mahammed A, Farkas DL, Gray HB, Gross Z, Medina-Kauwe LK. Tumor detection and elimination by a targeted gallium corrole. Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6105-10. PMID: 19342490.
      View in: PubMed
    21. Hwang JY, Agadjanian H, Medina-Kauwe LK, Gross Z, Gray HB, Sorasaenee K, Farkas DL. Large Field of View Scanning Fluorescence Lifetime Imaging System for Multimode Optical Imaging of Small Animals. Proc SPIE Int Soc Opt Eng. 2008 Mar; 6859. PMID: 29386697.
      View in: PubMed
    22. Haber A, Agadjanian H, Medina-Kauwe LK, Gross Z. Corroles that bind with high affinity to both apo and holo transferrin. J Inorg Biochem. 2008 Mar; 102(3):446-57. PMID: 18180041.
      View in: PubMed
    23. Medina-Kauwe LK. "Alternative" endocytic mechanisms exploited by pathogens: new avenues for therapeutic delivery? Adv Drug Deliv Rev. 2007 Aug 10; 59(8):798-809. PMID: 17707545.
      View in: PubMed
    24. Xie J, Chiang L, Contreras J, Wu K, Garner JA, Medina-Kauwe L, Hamm-Alvarez SF. Novel fiber-dependent entry mechanism for adenovirus serotype 5 in lacrimal acini. J Virol. 2006 Dec; 80(23):11833-51. PMID: 16987972.
      View in: PubMed
    25. Candolfi M, Curtin JF, Xiong WD, Kroeger KM, Liu C, Rentsendorj A, Agadjanian H, Medina-Kauwe L, Palmer D, Ng P, Lowenstein PR, Castro MG. Effective high-capacity gutless adenoviral vectors mediate transgene expression in human glioma cells. Mol Ther. 2006 Sep; 14(3):371-81. PMID: 16798098.
      View in: PubMed
    26. Rentsendorj A, Xie J, MacVeigh M, Agadjanian H, Bass S, Kim DH, Rossi J, Hamm-Alvarez SF, Medina-Kauwe LK. Typical and atypical trafficking pathways of Ad5 penton base recombinant protein: implications for gene transfer. Gene Ther. 2006 May; 13(10):821-36. PMID: 16482205.
      View in: PubMed
    27. Agadjanian H, Weaver JJ, Mahammed A, Rentsendorj A, Bass S, Kim J, Dmochowski IJ, Margalit R, Gray HB, Gross Z, Medina-Kauwe LK. Specific delivery of corroles to cells via noncovalent conjugates with viral proteins. Pharm Res. 2006 Feb; 23(2):367-77. PMID: 16411149.
      View in: PubMed
    28. Xiong W, Goverdhana S, Sciascia SA, Candolfi M, Zirger JM, Barcia C, Curtin JF, King GD, Jaita G, Liu C, Kroeger K, Agadjanian H, Medina-Kauwe L, Palmer D, Ng P, Lowenstein PR, Castro MG. Regulatable gutless adenovirus vectors sustain inducible transgene expression in the brain in the presence of an immune response against adenoviruses. J Virol. 2006 Jan; 80(1):27-37. PMID: 16352528.
      View in: PubMed
    29. Medina-Kauwe LK, Xie J, Hamm-Alvarez S. Intracellular trafficking of nonviral vectors. Gene Ther. 2005 Dec; 12(24):1734-51. PMID: 16079885.
      View in: PubMed
    30. Medina-Kauwe LK. Introduction to the special issue: traveling the intracellular highway to gene therapy. Gene Ther. 2005 Jun; 12(11):863-4. PMID: 15908993.
      View in: PubMed
    31. Rentsendorj A, Agadjanian H, Chen X, Cirivello M, Macveigh M, Kedes L, Hamm-Alvarez S, Medina-Kauwe LK. The Ad5 fiber mediates nonviral gene transfer in the absence of the whole virus, utilizing a novel cell entry pathway. Gene Ther. 2005 Feb; 12(3):225-37. PMID: 15483666.
      View in: PubMed
    32. Wang Y, Xie J, Yarber FA, Mazurek C, Trousdale MD, Medina-Kauwe LK, Kasahara N, Hamm-Alvarez SF. Adenoviral capsid modulates secretory compartment organization and function in acinar epithelial cells from rabbit lacrimal gland. Gene Ther. 2004 Jun; 11(12):970-81. PMID: 15029229.
      View in: PubMed
    33. Hamm-Alvarez SF, Xie J, Wang Y, Medina-Kauwe LK. Modulation of secretory functions in epithelia by adenovirus capsid proteins. J Control Release. 2003 Dec 05; 93(2):129-40. PMID: 14636719.
      View in: PubMed
    34. Medina-Kauwe LK. Endocytosis of adenovirus and adenovirus capsid proteins. Adv Drug Deliv Rev. 2003 Nov 14; 55(11):1485-96. PMID: 14597142.
      View in: PubMed
    35. Medina-Kauwe LK, Chen X. Using GFP--ligand fusions to measure receptor-mediated endocytosis in living cells. Vitam Horm. 2002; 65:81-95. PMID: 12481543.
      View in: PubMed
    36. Medina-Kauwe LK, Maguire M, Kasahara N, Kedes L. Nonviral gene delivery to human breast cancer cells by targeted Ad5 penton proteins. Gene Ther. 2001 Dec; 8(23):1753-61. PMID: 11803394.
      View in: PubMed
    37. Medina-Kauwe LK, Kasahara N, Kedes L. 3PO, a novel nonviral gene delivery system using engineered Ad5 penton proteins. Gene Ther. 2001 May; 8(10):795-803. PMID: 11420644.
      View in: PubMed
    38. Medina-Kauwe LK, Leung V, Wu L, Kedes L. Assessing the binding and endocytosis activity of cellular receptors using GFP-ligand fusions. Biotechniques. 2000 Sep; 29(3):602-4, 606-8, 609. PMID: 10997274.
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    39. Medina-Kauwe LK, Tobin AJ, De Meirleir L, Jaeken J, Jakobs C, Nyhan WL, Gibson KM. 4-Aminobutyrate aminotransferase (GABA-transaminase) deficiency. J Inherit Metab Dis. 1999 Jun; 22(4):414-27. PMID: 10407778.
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    40. Medina-Kauwe LK, Nyhan WL, Gibson KM, Tobin AJ. Identification of a familial mutation associated with GABA-transaminase deficiency disease. Neurobiol Dis. 1998 Aug; 5(2):89-96. PMID: 9746906.
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    41. Tillakaratne NJ, Medina-Kauwe L, Gibson KM. gamma-Aminobutyric acid (GABA) metabolism in mammalian neural and nonneural tissues. Comp Biochem Physiol A Physiol. 1995 Oct; 112(2):247-63. PMID: 7584821.
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    42. Medina-Kauwe LK, Tillakaratne NJ, Wu JY, Tobin AJ. A rat brain cDNA encodes enzymatically active GABA transaminase and provides a molecular probe for GABA-catabolizing cells. J Neurochem. 1994 Apr; 62(4):1267-75. PMID: 8133261.
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