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Stephan R Targan

Title(s)Professor-in-Residence, Medicine
SchoolMedicine
Address760 Westwood Plaza 32-144
Los Angeles CA 90024
Phone(310) 423-7723
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    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms of TL1A-driven Paneth Cell dysfunction in IBD
    NIH/NIDDK R01DK123511Jan 1, 2020 - Dec 31, 2023
    Role: Principal Investigator
    Molecular characterization of the role of RNASET2 in Severe Crohn's Disease
    NIH/NIDDK R01DK117893Sep 19, 2019 - Jul 31, 2022
    Role: Principal Investigator
    A genetic model of inflammatory bowel disease using human intestinal organoids.
    NIH/NIDDK R56DK106202Sep 5, 2015 - Aug 31, 2016
    Role: Principal Investigator
    Role of TRIF-Dependent TLR Signaling in Intestinal Mucosa
    NIH/NIAID R01AI095255Jul 1, 2012 - Jun 30, 2022
    Role: Principal Investigator
    The Cedars-Sinai Immunobiology Training Program
    NIH/NIAID T32AI089553Sep 1, 2010 - Aug 31, 2015
    Role: Co-Principal Investigator
    IBD--MUCOSA-SPECIFIC REGULATION OF IFN-GAMMA PRODUCTION
    NIH/NIDDK R01DK043211Mar 1, 2001 - Jun 30, 1992
    Role: Principal Investigator
    Role of TL1A in Severity of Crohn's Disease
    NIH/NIDDK R01DK056328Aug 15, 1999 - Jul 31, 2019
    Role: Principal Investigator
    IBD: Role of Genetic and Immunopathologic Mechanisms
    NIH/NIDDK P01DK046763Sep 30, 1992 - Sep 29, 2010
    Role: Principal Investigator
    IBD: Mucosa Specific Regulation of IFN-gamma Production
    NIH/NIDDK R37DK043211Sep 20, 1991 - Mar 31, 2011
    Role: Principal Investigator
    IBD: ROLE OF ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES
    NIH/NIDDK R01DK043026Jun 15, 1991 - May 31, 1995
    Role: Principal Investigator
    MECHANISM OF THE NK LETHAL HIT IN PROGRAMMED TUMOR CELLS
    NIH/NCI R01CA037205Mar 15, 1984 - Mar 31, 1991
    Role: Principal Investigator
    INFLAMMATORY BOWEL DISEASE: NK ACTIVITY IN GUT MUCOSA
    NIH/NIADDK R01AM027806Aug 1, 1981 - Jul 31, 1988
    Role: Principal Investigator
    INFLAMMATORY BOWEL DISEASE: NK ACTIVITY IN GUT MUCOSA
    NIH/NIDDK R01DK027806Aug 1, 1981 - Jul 31, 1988
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Reduced expression of COVID-19 host receptor, ACE2 is associated with small bowel inflammation, more severe disease, and response to anti-TNF therapy in Crohn's disease. medRxiv. 2020 Apr 23. Potdar AA, Dube S, Naito T, Botwin G, Haritunians T, Li D, Yang S, Bilsborough J, Denson LA, Daly M, Targan SR, Fleshner P, Braun J, Kugathasan S, Stappenbeck TS, McGovern DPB. PMID: 32511625.
      View in: PubMed   Mentions:
    2. Hypoalbuminemia and Bandemia Predict Failure of Infliximab Rescue Therapy in Acute Severe Ulcerative Colitis. Dig Dis Sci. 2020 Mar 13. Syal G, Robbins L, Kashani A, Bonthala N, Feldman E, Fleshner P, Vasiliauskas E, McGovern D, Ha C, Targan S, Melmed GY. PMID: 32170473.
      View in: PubMed   Mentions:    Fields:    
    3. Development of Physiologically Responsive Human iPSC-Derived Intestinal Epithelium to Study Barrier Dysfunction in IBD. Int J Mol Sci. 2020 Feb 20; 21(4). Gleeson JP, Estrada HQ, Yamashita M, Svendsen CN, Targan SR, Barrett RJ. PMID: 32093254.
      View in: PubMed   Mentions:    Fields:    
    4. Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis. N Engl J Med. 2019 09 26; 381(13):1201-1214. Sands BE, Sandborn WJ, Panaccione R, O'Brien CD, Zhang H, Johanns J, Adedokun OJ, Li K, Peyrin-Biroulet L, Van Assche G, Danese S, Targan S, Abreu MT, Hisamatsu T, Szapary P, Marano C. PMID: 31553833.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    5. Ileal Gene Expression Data from Crohn's Disease Small Bowel Resections Indicate Distinct Clinical Subgroups. J Crohns Colitis. 2019 Aug 14; 13(8):1055-1066. Potdar AA, Li D, Haritunians T, VanDussen KL, Fiorino MF, Liu TC, Stappenbeck TS, Fleshner P, Targan SR, McGovern DPB, Bilsborough J. PMID: 30877309.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    6. Malassezia Is Associated with Crohn's Disease and Exacerbates Colitis in Mouse Models. Cell Host Microbe. 2019 Mar 13; 25(3):377-388.e6. Limon JJ, Tang J, Li D, Wolf AJ, Michelsen KS, Funari V, Gargus M, Nguyen C, Sharma P, Maymi VI, Iliev ID, Skalski JH, Brown J, Landers C, Borneman J, Braun J, Targan SR, McGovern DPB, Underhill DM. PMID: 30850233.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    7. A role for BATF3 in TH9 differentiation and T-cell-driven mucosal pathologies. Mucosal Immunol. 2019 05; 12(3):644-655. Tsuda M, Hamade H, Thomas LS, Salumbides BC, Potdar AA, Wong MH, Nunnelee JS, Stamps JT, Neutzsky-Wulff AV, Barrett RJ, Wang Y, Tang J, Funari VA, Targan SR, Michelsen KS. PMID: 30617301.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    8. Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate Lymphoid Cell-Mediated Barrier Protection and Intestinal T Cell Activation during Colitis. Immunity. 2018 12 18; 49(6):1077-1089.e5. Castellanos JG, Woo V, Viladomiu M, Putzel G, Lima S, Diehl GE, Marderstein AR, Gandara J, Perez AR, Withers DR, Targan SR, Shih DQ, Scherl EJ, Longman RS. PMID: 30552020.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    9. A Multidisciplinary Approach to Biopsychosocial Care for Adults With Inflammatory Bowel Disease: A Pilot Study. Inflamm Bowel Dis. 2018 11 29; 24(12):2550-2554. Lee CK, Melmed GY, Mann A, Danovitch I, Hedrick R, McGovern DPB, Targan S, Shih D, Vasiliauskas E, IsHak WW, Feldman E. PMID: 29920581.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Late-Onset Crohn's Disease Is A Subgroup Distinct in Genetic and Behavioral Risk Factors With UC-Like Characteristics. Inflamm Bowel Dis. 2018 10 12; 24(11):2413-2422. Li D, Haritunians T, Landers C, Potdar AA, Yang S, Huang H, Schumm LP, Daly M, Targan SR, McGovern DPB. PMID: 29860388.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Inflammation-independent TL1A-mediated intestinal fibrosis is dependent on the gut microbiome. Mucosal Immunol. 2018 09; 11(5):1466-1476. Jacob N, Jacobs JP, Kumagai K, Ha CWY, Kanazawa Y, Lagishetty V, Altmayer K, Hamill AM, Von Arx A, Sartor RB, Devkota S, Braun J, Michelsen KS, Targan SR, Shih DQ. PMID: 29988118.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    12. Serological, genetic and clinical associations with increased health-care resource utilization in inflammatory bowel disease. J Dig Dis. 2018 Jan; 19(1):15-23. Gu P, Kapur A, Li D, Haritunians T, Vasiliauskas E, Shih DQ, Targan SR, Spiegel BM, Mcgovern DP, Black JT, Melmed GY. PMID: 29251413.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips. Cell Mol Gastroenterol Hepatol. 2018; 5(4):669-677.e2. Workman MJ, Gleeson JP, Troisi EJ, Estrada HQ, Kerns SJ, Hinojosa CD, Hamilton GA, Targan SR, Svendsen CN, Barrett RJ. PMID: 29930984.
      View in: PubMed   Mentions: 11     Fields:    
    14. TL1A blocking ameliorates intestinal fibrosis in the T cell transfer model of chronic colitis in mice. Pathol Res Pract. 2018 Feb; 214(2):217-227. Li H, Song J, Niu G, Zhang H, Guo J, Shih DQ, Targan SR, Zhang X. PMID: 29254800.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    15. Colonic Phenotypes Are Associated with Poorer Response to Anti-TNF Therapies in Patients with IBD. Inflamm Bowel Dis. 2017 08; 23(8):1382-1393. Yoon SM, Haritunians T, Chhina S, Liu Z, Yang S, Landers C, Li D, Ye BD, Shih D, Vasiliauskas EA, Ippoliti A, Rabizadeh S, Targan SR, Melmed GY, McGovern DPB. PMID: 28590340.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    16. Association of Ribonuclease T2 Gene Polymorphisms With Decreased Expression and Clinical Characteristics of Severity in Crohn's Disease. Gastroenterology. 2017 07; 153(1):219-232. Gonsky R, Fleshner P, Deem RL, Biener-Ramanujan E, Li D, Potdar AA, Bilsborough J, Yang S, McGovern DPB, Targan SR. PMID: 28400196.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    17. Myeloid ATG16L1 Facilitates Host-Bacteria Interactions in Maintaining Intestinal Homeostasis. J Immunol. 2017 03 01; 198(5):2133-2146. Zhang H, Zheng L, McGovern DP, Hamill AM, Ichikawa R, Kanazawa Y, Luu J, Kumagai K, Cilluffo M, Fukata M, Targan SR, Underhill DM, Zhang X, Shih DQ. PMID: 28130498.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    18. Ustekinumab as Induction and Maintenance Therapy for Crohn's Disease. N Engl J Med. 2016 11 17; 375(20):1946-1960. Feagan BG, Sandborn WJ, Gasink C, Jacobstein D, Lang Y, Friedman JR, Blank MA, Johanns J, Gao LL, Miao Y, Adedokun OJ, Sands BE, Hanauer SB, Vermeire S, Targan S, Ghosh S, de Villiers WJ, Colombel JF, Tulassay Z, Seidler U, Salzberg BA, Desreumaux P, Lee SD, Loftus EV, Dieleman LA, Katz S, Rutgeerts P. PMID: 27959607.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansCTClinical Trials
    19. The TNF family member TL1A induces IL-22 secretion in committed human Th17 cells via IL-9 induction. J Leukoc Biol. 2017 03; 101(3):727-737. Thomas LS, Targan SR, Tsuda M, Yu QT, Salumbides BC, Haritunians T, Mengesha E, McGovern DP, Michelsen KS. PMID: 27733581.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    20. Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease. Gastroenterology. 2017 01; 152(1):206-217.e2. Brant SR, Okou DT, Simpson CL, Cutler DJ, Haritunians T, Bradfield JP, Chopra P, Prince J, Begum F, Kumar A, Huang C, Venkateswaran S, Datta LW, Wei Z, Thomas K, Herrinton LJ, Klapproth JA, Quiros AJ, Seminerio J, Liu Z, Alexander JS, Baldassano RN, Dudley-Brown S, Cross RK, Dassopoulos T, Denson LA, Dhere TA, Dryden GW, Hanson JS, Hou JK, Hussain SZ, Hyams JS, Isaacs KL, Kader H, Kappelman MD, Katz J, Kellermayer R, Kirschner BS, Kuemmerle JF, Kwon JH, Lazarev M, Li E, Mack D, Mannon P, Moulton DE, Newberry RD, Osuntokun BO, Patel AS, Saeed SA, Targan SR, Valentine JF, Wang MH, Zonca M, Rioux JD, Duerr RH, Silverberg MS, Cho JH, Hakonarson H, Zwick ME, McGovern DP, Kugathasan S. PMID: 27693347.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    21. A Randomized, Double-Blind, Placebo-Controlled Phase 2 Study of Brodalumab in Patients With Moderate-to-Severe Crohn's Disease. Am J Gastroenterol. 2016 Nov; 111(11):1599-1607. Targan SR, Feagan B, Vermeire S, Panaccione R, Melmed GY, Landers C, Li D, Russell C, Newmark R, Zhang N, Chon Y, Hsu YH, Lin SL, Klekotka P. PMID: 27481309.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCTClinical Trials
    22. A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn's Disease and Human Gut Microbiome Composition. Gastroenterology. 2016 10; 151(4):724-32. Li D, Achkar JP, Haritunians T, Jacobs JP, Hui KY, D'Amato M, Brand S, Radford-Smith G, Halfvarson J, Niess JH, Kugathasan S, Büning C, Schumm LP, Klei L, Ananthakrishnan A, Aumais G, Baidoo L, Dubinsky M, Fiocchi C, Glas J, Milgrom R, Proctor DD, Regueiro M, Simms LA, Stempak JM, Targan SR, Törkvist L, Sharma Y, Devlin B, Borneman J, Hakonarson H, Xavier RJ, Daly M, Brant SR, Rioux JD, Silverberg MS, Cho JH, Braun J, McGovern DP, Duerr RH. PMID: 27492617.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    23. Outcomes with Anti-Tumour Necrosis Factor-Alpha Therapy and Serology in Patients with Denovo Crohn's Disease After Ileal Pouch Anal Anastomosis. J Crohns Colitis. 2017 Jan; 11(1):77-83. Robbins L, Zaghiyan K, Melmed G, Vasiliauskas E, Ahmed S, McGovern D, Rabizadeh S, Singh N, Landers C, Ippoliti A, Shih D, Targan S, Fleshner P. PMID: 27466172.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    24. Clinical Factors Associated with the Development of Crohn's Disease in Inflammatory Bowel Disease-unclassified Patients Undergoing Ileal Pouch-anal Anastomosis. Inflamm Bowel Dis. 2016 06; 22(6):1397-402. Koh SZ, Zaghiyan KN, Li Q, Rabizadeh S, Melmed GY, Targan SR, Fleshner PR. PMID: 26978722.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    25. TNFRSF1B Is Associated with ANCA in IBD. Inflamm Bowel Dis. 2016 06; 22(6):1346-52. Li D, Silverberg MS, Haritunians T, Dubinsky MC, Landers C, Stempak JM, Milgrom R, Guo X, Chen YD, Rotter JI, Taylor KD, McGovern DP, Targan SR. PMID: 27104820.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    26. Cytokine and anti-cytokine therapies in prevention or treatment of fibrosis in IBD. United European Gastroenterol J. 2016 Aug; 4(4):531-40. Jacob N, Targan SR, Shih DQ. PMID: 27536363.
      View in: PubMed   Mentions:
    27. Perianal Crohn's Disease is Associated with Distal Colonic Disease, Stricturing Disease Behavior, IBD-Associated Serologies and Genetic Variation in the JAK-STAT Pathway. Inflamm Bowel Dis. 2016 Apr; 22(4):862-9. Kaur M, Panikkath D, Yan X, Liu Z, Berel D, Li D, Vasiliauskas EA, Ippoliti A, Dubinsky M, Shih DQ, Melmed GY, Haritunians T, Fleshner P, Targan SR, McGovern DP. PMID: 26937622.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    28. Differential Levels of Tl1a Affect the Expansion and Function of Regulatory T Cells in Modulating Murine Colitis. Inflamm Bowel Dis. 2016 Mar; 22(3):548-59. Sidhu-Varma M, Shih DQ, Targan SR. PMID: 26818423.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    29. Nonbloody Diarrhea but Not Significant Weight Loss at Diagnosis Is Associated with the Development of Denovo Crohn's Disease After Ileal Pouch-anal Anastomosis for Ulcerative Colitis. Inflamm Bowel Dis. 2016 Mar; 22(3):654-61. Ahmed S, Melmed G, McGovern D, Robbins LA, Shih D, Vasiliauskas E, Singh N, Rabidzadeh S, Ippoliti A, Targan S, Fleshner P. PMID: 26595552.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    30. Ocular Manifestations in Inflammatory Bowel Disease Are Associated with Other Extra-intestinal Manifestations, Gender, and Genes Implicated in Other Immune-related Traits. J Crohns Colitis. 2016 Jan; 10(1):43-9. Taleban S, Li D, Targan SR, Ippoliti A, Brant SR, Cho JH, Duerr RH, Rioux JD, Silverberg MS, Vasiliauskas EA, Rotter JI, Haritunians T, Shih DQ, Dubinsky M, Melmed GY, McGovern DP. PMID: 26449790.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    31. Colectomy with Permanent End Ileostomy Is More Cost-Effective than Ileal Pouch-Anal Anastomosis for Crohn's Colitis. Dig Dis Sci. 2016 Feb; 61(2):550-9. Taleban S, Van Oijen MG, Vasiliauskas EA, Fleshner PR, Shen B, Ippoliti AF, Targan SR, Melmed GY. PMID: 26434930.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    32. Combined Immunosuppression Impairs Immunogenicity to Tetanus and Pertussis Vaccination Among Patients with Inflammatory Bowel Disease. Inflamm Bowel Dis. 2015 Aug; 21(8):1754-60. Dezfoli S, Horton HA, Thepyasuwan N, Berel D, Targan SR, Vasiliauskas EA, Dubinsky M, Shih DQ, Kaur M, McGovern DP, Ippoliti A, Feldman EJ, Melmed GY. PMID: 25985242.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansPHPublic Health
    33. Pyoderma Gangrenosum among Patients with Inflammatory Bowel Disease: A Descriptive Cohort Study. J Cutan Med Surg. 2015 Mar-Apr; 19(2):125-31. Weizman AV, Huang B, Targan S, Dubinsky M, Fleshner P, Kaur M, Ippoliti A, Panikkath D, Vasiliauskas E, Shih D, McGovern DP, Melmed GY. PMID: 25775631.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    34. The impact of preoperative serum anti-TNFa therapy levels on early postoperative outcomes in inflammatory bowel disease surgery. Ann Surg. 2015 Mar; 261(3):487-96. Lau C, Dubinsky M, Melmed G, Vasiliauskas E, Berel D, McGovern D, Ippoliti A, Shih D, Targan S, Fleshner P. PMID: 24950263.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    35. Molecular patterns in human ulcerative colitis and correlation with response to infliximab. Inflamm Bowel Dis. 2014 Dec; 20(12):2353-63. Halloran B, Chang J, Shih DQ, McGovern D, Famulski K, Evaschesen C, Fedorak RN, Thiesen A, Targan S, Halloran PF. PMID: 25397893.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    36. Reliable generation of induced pluripotent stem cells from human lymphoblastoid cell lines. Stem Cells Transl Med. 2014 Dec; 3(12):1429-34. Barrett R, Ornelas L, Yeager N, Mandefro B, Sahabian A, Lenaeus L, Targan SR, Svendsen CN, Sareen D. PMID: 25298370.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    37. IFNG rs1861494 polymorphism is associated with IBD disease severity and functional changes in both IFNG methylation and protein secretion. Inflamm Bowel Dis. 2014 Oct; 20(10):1794-801. Gonsky R, Deem RL, Landers CJ, Haritunians T, Yang S, Targan SR. PMID: 25171510.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    38. Use of animal models in elucidating disease pathogenesis in IBD. Semin Immunopathol. 2014 Sep; 36(5):541-51. Khanna PV, Shih DQ, Haritunians T, McGovern DP, Targan S. PMID: 25212688.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    39. Antibiotics for Treatment of Clostridium difficile Infection in Hospitalized Patients with Inflammatory Bowel Disease. Antimicrob Agents Chemother. 2014 Sep; 58(9):5054-9. Horton HA, Dezfoli S, Berel D, Hirsch J, Ippoliti A, McGovern D, Kaur M, Shih D, Dubinsky M, Targan SR, Fleshner P, Vasiliauskas EA, Grein J, Murthy R, Melmed GY. PMID: 24913174.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    40. Clinical, serologic, and genetic factors associated with pyoderma gangrenosum and erythema nodosum in inflammatory bowel disease patients. Inflamm Bowel Dis. 2014 Mar; 20(3):525-33. Weizman A, Huang B, Berel D, Targan SR, Dubinsky M, Fleshner P, Ippoliti A, Kaur M, Panikkath D, Brant S, Oikonomou I, Duerr R, Rioux J, Silverberg M, Rotter JI, Vasiliauskas E, Haritunians T, Shih D, Li D, Melmed GY, McGovern DP. PMID: 24487271.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    41. Weeding out the facts: the reality about cannabis and Crohn's disease. Clin Gastroenterol Hepatol. 2014 May; 12(5):898-9. Vu MP, Melmed GY, Targan SR. PMID: 24269921.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    42. Multidimensional prognostic risk assessment identifies association between IL12B variation and surgery in Crohn's disease. Inflamm Bowel Dis. 2013 Jul; 19(8):1662-70. Dubinsky MC, Kugathasan S, Kwon S, Haritunians T, Wrobel I, Wahbeh G, Quiros A, Bahar R, Silber G, Farrior S, Stephens M, Teleten N, Panikkath D, Ippoliti A, Vasiliauskas E, Fleshner P, Williams C, Landers C, Rotter JI, Targan SR, Taylor KD, McGovern DP. PMID: 23665963.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    43. Multiple activating and repressive cis-promoter regions regulate TNFSF15 expression in human primary mononuclear cells. Cytokine. 2013 Jul; 63(1):36-42. Gonsky R, Deem RL, Targan SR. PMID: 23642711.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    44. Human monoclonal antibodies against Clostridium difficile toxins A and B inhibit inflammatory and histologic responses to the toxins in human colon and peripheral blood monocytes. Antimicrob Agents Chemother. 2013 Jul; 57(7):3214-23. Koon HW, Shih DQ, Hing TC, Yoo JH, Ho S, Chen X, Kelly CP, Targan SR, Pothoulakis C. PMID: 23629713.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    45. SUSTAINED TL1A (TNFSF15) EXPRESSION ON BOTH LYMPHOID AND MYELOID CELLS LEADS TO MILD SPONTANEOUS INTESTINAL INFLAMMATION AND FIBROSIS. Eur J Microbiol Immunol (Bp). 2013 Mar; 3(1):11-20. Zheng L, Zhang X, Chen J, Ichikawa R, Wallace K, Pothoulakis C, Koon HW, Targan SR, Shih DQ. PMID: 23638306.
      View in: PubMed   Mentions:
    46. HMPL-004 (Andrographis paniculata extract) prevents development of murine colitis by inhibiting T-cell proliferation and TH1/TH17 responses. Inflamm Bowel Dis. 2013 Jan; 19(1):151-64. Michelsen KS, Wong MH, Ko B, Thomas LS, Dhall D, Targan SR. PMID: 23292349.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    47. Surgical outcome of ileal pouch-anal anastomosis when used intentionally for well-defined Crohn's disease. Inflamm Bowel Dis. 2013 Jan; 19(1):30-6. Le Q, Melmed G, Dubinsky M, McGovern D, Vasiliauskas EA, Murrell Z, Ippoliti A, Shih D, Kaur M, Targan S, Fleshner P. PMID: 22467562.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    48. Assessing health status in inflammatory bowel disease using a novel single-item numeric rating scale. Dig Dis Sci. 2013 May; 58(5):1313-21. Surti B, Spiegel B, Ippoliti A, Vasiliauskas EA, Simpson P, Shih DQ, Targan SR, McGovern DP, Melmed GY. PMID: 23250673.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    49. B lymphocyte-induced maturation protein-1 contributes to intestinal mucosa homeostasis by limiting the number of IL-17-producing CD4+ T cells. J Immunol. 2012 Dec 15; 189(12):5682-93. Salehi S, Bankoti R, Benevides L, Willen J, Couse M, Silva JS, Dhall D, Meffre E, Targan S, Martins GA. PMID: 23162130.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    50. Ustekinumab induction and maintenance therapy in refractory Crohn's disease. N Engl J Med. 2012 Oct 18; 367(16):1519-28. Sandborn WJ, Gasink C, Gao LL, Blank MA, Johanns J, Guzzo C, Sands BE, Hanauer SB, Targan S, Rutgeerts P, Ghosh S, de Villiers WJ, Panaccione R, Greenberg G, Schreiber S, Lichtiger S, Feagan BG. PMID: 23075178.
      View in: PubMed   Mentions: 219     Fields:    Translation:HumansCTClinical Trials
    51. The antimicrobial peptide cathelicidin modulates Clostridium difficile-associated colitis and toxin A-mediated enteritis in mice. Gut. 2013 Sep; 62(9):1295-305. Hing TC, Ho S, Shih DQ, Ichikawa R, Cheng M, Chen J, Chen X, Law I, Najarian R, Kelly CP, Gallo RL, Targan SR, Pothoulakis C, Koon HW. PMID: 22760006.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    52. Does preoperative immunosuppression influence unplanned hospital readmission after surgery in patients with Crohn's disease? Dis Colon Rectum. 2012 May; 55(5):563-8. White EC, Melmed GY, Vasiliauskas E, Dubinsky M, Ippoliti A, McGovern D, Targan S, Fleshner P. PMID: 22513435.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    53. Colorectal cancer screening and surveillance in Crohn's colitis. J Crohns Colitis. 2012 Sep; 6(8):824-9. Basseri RJ, Basseri B, Vassilaki ME, Melmed GY, Ippoliti A, Vasiliauskas EA, Fleshner PR, Lechago J, Hu B, Berel D, Targan SR, Papadakis KA. PMID: 22398087.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    54. Constitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces fibrostenosis. Am J Pathol. 2012 Feb; 180(2):636-49. Barrett R, Zhang X, Koon HW, Vu M, Chang JY, Yeager N, Nguyen MA, Michelsen KS, Berel D, Pothoulakis C, Targan SR, Shih DQ. PMID: 22138299.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    55. Substance P induces CCN1 expression via histone deacetylase activity in human colonic epithelial cells. Am J Pathol. 2011 Nov; 179(5):2315-26. Koon HW, Shih DQ, Hing TC, Chen J, Ho S, Zhao D, Targan SR, Pothoulakis C. PMID: 21945803.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    56. Cathelicidin signaling via the Toll-like receptor protects against colitis in mice. Gastroenterology. 2011 Nov; 141(5):1852-63.e1-3. Koon HW, Shih DQ, Chen J, Bakirtzi K, Hing TC, Law I, Ho S, Ichikawa R, Zhao D, Xu H, Gallo R, Dempsey P, Cheng G, Targan SR, Pothoulakis C. PMID: 21762664.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    57. Assessing inflammatory bowel disease-associated antibodies in Caucasian and First Nations cohorts. Can J Gastroenterol. 2011 May; 25(5):269-73. Bernstein CN, El-Gabalawy H, Sargent M, Landers C, Rawsthorne P, Elias B, Targan SR. PMID: 21647462.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    58. Variants in ZNF365 isoform D are associated with Crohn's disease. Gut. 2011 Aug; 60(8):1060-7. Haritunians T, Jones MR, McGovern DP, Shih DQ, Barrett RJ, Derkowski C, Dubinsky MC, Dutridge D, Fleshner PR, Ippoliti A, King L, Leshinsky-Silver E, Levine A, Melmed GY, Mengesha E, Vasilauskas EA, Ziaee S, Rotter JI, Targan SR, Taylor KD. PMID: 21257989.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    59. Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosis. PLoS One. 2011 Jan 11; 6(1):e16090. Shih DQ, Barrett R, Zhang X, Yeager N, Koon HW, Phaosawasdi P, Song Y, Ko B, Wong MH, Michelsen KS, Martins G, Pothoulakis C, Targan SR. PMID: 21264313.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    60. Insights into TL1A and IBD pathogenesis. Adv Exp Med Biol. 2011; 691:279-88. Shih DQ, Michelsen KS, Barrett RJ, Biener-Ramanujan E, Gonsky R, Zhang X, Targan SR. PMID: 21153332.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    61. Distinct IFNG methylation in a subset of ulcerative colitis patients based on reactivity to microbial antigens. Inflamm Bowel Dis. 2011 Jan; 17(1):171-8. Gonsky R, Deem RL, Landers CJ, Derkowski CA, Berel D, McGovern DP, Targan SR. PMID: 20848535.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    62. Introductory words about TL1A/DR3. Adv Exp Med Biol. 2011; 691:271-4. Targan SR. PMID: 21153330.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    63. Genetic predictors of medically refractory ulcerative colitis. Inflamm Bowel Dis. 2010 Nov; 16(11):1830-40. Haritunians T, Taylor KD, Targan SR, Dubinsky M, Ippoliti A, Kwon S, Guo X, Melmed GY, Berel D, Mengesha E, Psaty BM, Glazer NL, Vasiliauskas EA, Rotter JI, Fleshner PR, McGovern DP. PMID: 20848476.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    64. High levels of Crohn's disease-associated anti-microbial antibodies are present and independent of colitis in chronic granulomatous disease. Clin Immunol. 2011 Jan; 138(1):14-22. Yu JE, De Ravin SS, Uzel G, Landers C, Targan S, Malech HL, Holland SM, Cao W, Harpaz N, Mayer L, Cunningham-Rundles C. PMID: 20956091.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    65. Genome wide association (GWA) predictors of anti-TNFalpha therapeutic responsiveness in pediatric inflammatory bowel disease. Inflamm Bowel Dis. 2010 Aug; 16(8):1357-66. Dubinsky MC, Mei L, Friedman M, Dhere T, Haritunians T, Hakonarson H, Kim C, Glessner J, Targan SR, McGovern DP, Taylor KD, Rotter JI. PMID: 20014019.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    66. Combination of innate and adaptive immune alterations increased the likelihood of fibrostenosis in Crohn's disease. Inflamm Bowel Dis. 2010 Aug; 16(8):1279-85. Ippoliti A, Devlin S, Mei L, Yang H, Papadakis KA, Vasiliauskas EA, McGovern DP, Abreu MT, Melmed G, Shaye O, Enayati P, Chen G, Choi J, Taylor K, Landers CJ, Rotter JI, Targan SR. PMID: 20027650.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    67. A prospective analysis of clinical variables, serologic factors, and outcome of ileal pouch-anal anastomosis in patients with backwash ileitis. Dis Colon Rectum. 2010 Jul; 53(7):987-94. White E, Melmed GY, Vasiliauskas EA, Dubinsky M, Berel D, Targan SR, Fleshner PR. PMID: 20551749.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    68. Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease. Hum Mol Genet. 2010 Sep 01; 19(17):3468-76. McGovern DP, Jones MR, Taylor KD, Marciante K, Yan X, Dubinsky M, Ippoliti A, Vasiliauskas E, Berel D, Derkowski C, Dutridge D, Fleshner P, Shih DQ, Melmed G, Mengesha E, King L, Pressman S, Haritunians T, Guo X, Targan SR, Rotter JI. PMID: 20570966.
      View in: PubMed   Mentions: 115     Fields:    Translation:Humans
    69. Functional signaling of membrane-bound TL1A induces IFN-gamma expression. FEBS Lett. 2010 Jun 03; 584(11):2376-80. Biener-Ramanujan E, Gonsky R, Ko B, Targan SR. PMID: 20403353.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    70. TL1A selectively enhances IL-12/IL-18-induced NK cell cytotoxicity against NK-resistant tumor targets. J Clin Immunol. 2010 Jul; 30(4):531-8. Heidemann SC, Chavez V, Landers CJ, Kucharzik T, Prehn JL, Targan SR. PMID: 20349123.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    71. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet. 2010 Apr; 42(4):332-7. McGovern DP, Gardet A, Törkvist L, Goyette P, Essers J, Taylor KD, Neale BM, Ong RT, Lagacé C, Li C, Green T, Stevens CR, Beauchamp C, Fleshner PR, Carlson M, D'Amato M, Halfvarson J, Hibberd ML, Lördal M, Padyukov L, Andriulli A, Colombo E, Latiano A, Palmieri O, Bernard EJ, Deslandres C, Hommes DW, de Jong DJ, Stokkers PC, Weersma RK, Sharma Y, Silverberg MS, Cho JH, Wu J, Roeder K, Brant SR, Schumm LP, Duerr RH, Dubinsky MC, Glazer NL, Haritunians T, Ippoliti A, Melmed GY, Siscovick DS, Vasiliauskas EA, Targan SR, Annese V, Wijmenga C, Pettersson S, Rotter JI, Xavier RJ, Daly MJ, Rioux JD, Seielstad M. PMID: 20228799.
      View in: PubMed   Mentions: 246     Fields:    Translation:Humans
    72. Preoperative wireless capsule endoscopy does not predict outcome after ileal pouch-anal anastomosis. Dis Colon Rectum. 2010 Mar; 53(3):293-300. Murrell Z, Vasiliauskas E, Melmed G, Lo S, Targan S, Fleshner P. PMID: 20173476.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    73. Future biologic targets for IBD: potentials and pitfalls. Nat Rev Gastroenterol Hepatol. 2010 Feb; 7(2):110-7. Melmed GY, Targan SR. PMID: 20134493.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    74. Microbial induction of inflammatory bowel disease associated gene TL1A (TNFSF15) in antigen presenting cells. Eur J Immunol. 2009 Nov; 39(11):3239-50. Shih DQ, Kwan LY, Chavez V, Cohavy O, Gonsky R, Chang EY, Chang C, Elson CO, Targan SR. PMID: 19839006.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    75. Rigorous histopathological assessment of the colectomy specimen in patients with inflammatory bowel disease unclassified does not predict outcome after ileal pouch-anal anastomosis. Am J Gastroenterol. 2010 Jan; 105(1):155-61. Nasseri Y, Melmed G, Wang HL, Targan S, Fleshner P. PMID: 19755970.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    76. Immunosuppression impairs response to pneumococcal polysaccharide vaccination in patients with inflammatory bowel disease. Am J Gastroenterol. 2010 Jan; 105(1):148-54. Melmed GY, Agarwal N, Frenck RW, Ippoliti AF, Ibanez P, Papadakis KA, Simpson P, Barolet-Garcia C, Ward J, Targan SR, Vasiliauskas EA. PMID: 19755964.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    77. TLR8-mediated activation of human monocytes inhibits TL1A expression. Eur J Immunol. 2009 Aug; 39(8):2195-202. Saruta M, Michelsen KS, Thomas LS, Yu QT, Landers CJ, Targan SR. PMID: 19637197.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    78. Distinct Methylation of IFNG in the Gut. J Interferon Cytokine Res. 2009 Jul; 29(7):407-14. Gonsky R, Deem RL, Targan SR. PMID: 19450149.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    79. Genetic epistasis of IL23/IL17 pathway genes in Crohn's disease. Inflamm Bowel Dis. 2009 Jun; 15(6):883-9. McGovern DP, Rotter JI, Mei L, Haritunians T, Landers C, Derkowski C, Dutridge D, Dubinsky M, Ippoliti A, Vasiliauskas E, Mengesha E, King L, Pressman S, Targan SR, Taylor KD. PMID: 19235914.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    80. A prospective evaluation of the long-term outcome of ileal pouch-anal anastomosis in patients with inflammatory bowel disease-unclassified and indeterminate colitis. Dis Colon Rectum. 2009 May; 52(5):872-8. Murrell ZA, Melmed GY, Ippoliti A, Vasiliauskas EA, Dubinsky M, Targan SR, Fleshner PR. PMID: 19502850.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    81. IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein. PLoS One. 2009; 4(3):e4719. Michelsen KS, Thomas LS, Taylor KD, Yu QT, Mei L, Landers CJ, Derkowski C, McGovern DP, Rotter JI, Targan SR. PMID: 19262684.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    82. High-frequency haplotypes in the X chromosome locus TLR8 are associated with both CD and UC in females. Inflamm Bowel Dis. 2009 Mar; 15(3):321-7. Saruta M, Targan SR, Mei L, Ippoliti AF, Taylor KD, Rotter JI. PMID: 18942751.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    83. Transient cytokine-induced liver injury following administration of the humanized anti-CD3 antibody visilizumab (HuM291) in Crohn's disease. Am J Gastroenterol. 2009 Apr; 104(4):868-76. Baumgart DC, Lowder JN, Targan SR, Sandborn WJ, Frankel MB. PMID: 19240707.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    84. MAGI2 genetic variation and inflammatory bowel disease. Inflamm Bowel Dis. 2009 Jan; 15(1):75-83. McGovern DP, Taylor KD, Landers C, Derkowski C, Dutridge D, Dubinsky M, Ippoliti A, Vasiliauskas E, Mei L, Mengesha E, King L, Pressman S, Targan SR, Rotter JI. PMID: 18720471.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    85. Enhanced CBir1-specific innate and adaptive immune responses in Crohn's disease. Inflamm Bowel Dis. 2008 Dec; 14(12):1641-51. Shen C, Landers CJ, Derkowski C, Elson CO, Targan SR. PMID: 18825772.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    86. IL23R haplotypes provide a large population attributable risk for Crohn's disease. Inflamm Bowel Dis. 2008 Sep; 14(9):1185-91. Taylor KD, Targan SR, Mei L, Ippoliti AF, McGovern D, Mengesha E, King L, Rotter JI. PMID: 18470928.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    87. Molecular imaging of murine intestinal inflammation with 2-deoxy-2-[18F]fluoro-D-glucose and positron emission tomography. Gastroenterology. 2008 Sep; 135(3):744-55. Brewer S, McPherson M, Fujiwara D, Turovskaya O, Ziring D, Chen L, Takedatsu H, Targan SR, Wei B, Braun J. PMID: 18639553.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    88. TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation. Gastroenterology. 2008 Aug; 135(2):552-67. Takedatsu H, Michelsen KS, Wei B, Landers CJ, Thomas LS, Dhall D, Braun J, Targan SR. PMID: 18598698.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCells
    89. Both preoperative perinuclear antineutrophil cytoplasmic antibody and anti-CBir1 expression in ulcerative colitis patients influence pouchitis development after ileal pouch-anal anastomosis. Clin Gastroenterol Hepatol. 2008 May; 6(5):561-8. Fleshner P, Ippoliti A, Dubinsky M, Vasiliauskas E, Mei L, Papadakis KA, Rotter JI, Landers C, Targan S. PMID: 18378498.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    90. Family history and serology predict Crohn's disease after ileal pouch-anal anastomosis for ulcerative colitis. Dis Colon Rectum. 2008 Jan; 51(1):100-8. Melmed GY, Fleshner PR, Bardakcioglu O, Ippoliti A, Vasiliauskas EA, Papadakis KA, Dubinsky M, Landers C, Rotter JI, Targan SR. PMID: 18085333.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    91. Does infliximab influence surgical morbidity of ileal pouch-anal anastomosis in patients with ulcerative colitis? Dis Colon Rectum. 2007 Nov; 50(11):1747-53. Schluender SJ, Ippoliti A, Dubinsky M, Vasiliauskas EA, Papadakis KA, Mei L, Targan SR, Fleshner PR. PMID: 17704969.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    92. TNFSF15 is an ethnic-specific IBD gene. Inflamm Bowel Dis. 2007 Nov; 13(11):1333-8. Picornell Y, Mei L, Taylor K, Yang H, Targan SR, Rotter JI. PMID: 17663424.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    93. Inflammatory bowel disease diagnosis, evaluation and classification: state-of-the art approach. Curr Opin Gastroenterol. 2007 Jul; 23(4):390-4. Targan SR, Karp LC. PMID: 17545774.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    94. A prospective multivariate analysis of clinical factors associated with pouchitis after ileal pouch-anal anastomosis. Clin Gastroenterol Hepatol. 2007 Aug; 5(8):952-8; quiz 887. Fleshner P, Ippoliti A, Dubinsky M, Ognibene S, Vasiliauskas E, Chelly M, Mei L, Papadakis KA, Landers C, Targan S. PMID: 17544871.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    95. Anti-flagellin (CBir1) phenotypic and genetic Crohn's disease associations. Inflamm Bowel Dis. 2007 May; 13(5):524-30. Papadakis KA, Yang H, Ippoliti A, Mei L, Elson CO, Hershberg RM, Vasiliauskas EA, Fleshner PR, Abreu MT, Taylor K, Landers CJ, Rotter JI, Targan SR. PMID: 17260364.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimals
    96. Predicting a change in diagnosis from ulcerative colitis to Crohn's disease: a nested, case-control study. Clin Gastroenterol Hepatol. 2007 May; 5(5):602-8; quiz 525. Melmed GY, Elashoff R, Chen GC, Nastaskin I, Papadakis KA, Vasiliauskas EA, Liu W, Landers C, Ippoliti AF, Targan SR. PMID: 17478347.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    97. IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease. Inflamm Bowel Dis. 2007 May; 13(5):511-5. Dubinsky MC, Wang D, Picornell Y, Wrobel I, Katzir L, Quiros A, Dutridge D, Wahbeh G, Silber G, Bahar R, Mengesha E, Targan SR, Taylor KD, Rotter JI. PMID: 17309073.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    98. CD56 marks an effector T cell subset in the human intestine. J Immunol. 2007 May 01; 178(9):5524-32. Cohavy O, Targan SR. PMID: 17442934.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    99. Natalizumab for the treatment of active Crohn's disease: results of the ENCORE Trial. Gastroenterology. 2007 May; 132(5):1672-83. Targan SR, Feagan BG, Fedorak RN, Lashner BA, Panaccione R, Present DH, Spehlmann ME, Rutgeerts PJ, Tulassay Z, Volfova M, Wolf DC, Hernandez C, Bornstein J, Sandborn WJ. PMID: 17484865.
      View in: PubMed   Mentions: 137     Fields:    Translation:Humans
    100. Phenotype and effector function of CC chemokine receptor 9-expressing lymphocytes in small intestinal Crohn's disease. J Immunol. 2007 Mar 01; 178(5):3293-300. Saruta M, Yu QT, Avanesyan A, Fleshner PR, Targan SR, Papadakis KA. PMID: 17312180.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCellsCTClinical Trials
    101. Antibodies to I2 predict clinical response to fecal diversion in Crohn's disease. Inflamm Bowel Dis. 2006 Dec; 12(12):1122-30. Spivak J, Landers CJ, Vasiliauskas EA, Abreu MT, Dubinsky MC, Papadakis KA, Ippoliti A, Targan SR, Fleshner PR. PMID: 17119386.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCellsCTClinical Trials
    102. NOD2 variants and antibody response to microbial antigens in Crohn's disease patients and their unaffected relatives. Gastroenterology. 2007 Feb; 132(2):576-86. Devlin SM, Yang H, Ippoliti A, Taylor KD, Landers CJ, Su X, Abreu MT, Papadakis KA, Vasiliauskas EA, Melmed GY, Fleshner PR, Mei L, Rotter JI, Targan SR. PMID: 17258734.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    103. Case report: evidence for transplacental transfer of maternally administered infliximab to the newborn. Clin Gastroenterol Hepatol. 2006 Oct; 4(10):1255-8. Vasiliauskas EA, Church JA, Silverman N, Barry M, Targan SR, Dubinsky MC. PMID: 17045211.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    104. Current limitations of IBD treatment: where do we go from here? Ann N Y Acad Sci. 2006 Aug; 1072:1-8. Targan SR. PMID: 17057185.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    105. Molecular approaches to the role of the microbiota in inflammatory bowel disease. Ann N Y Acad Sci. 2006 Aug; 1072:39-51. Elson CO, Cong Y, Qi F, Hershberg RM, Targan SR. PMID: 17057189.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    106. Patients with inflammatory bowel disease are at risk for vaccine-preventable illnesses. Am J Gastroenterol. 2006 Aug; 101(8):1834-40. Melmed GY, Ippoliti AF, Papadakis KA, Tran TT, Birt JL, Lee SK, Frenck RW, Targan SR, Vasiliauskas EA. PMID: 16817843.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansPHPublic Health
    107. Immunogenetic phenotypes in inflammatory bowel disease. World J Gastroenterol. 2006 Jun 21; 12(23):3645-50. Dubinsky MC, Taylor K, Targan SR, Rotter JI. PMID: 16773679.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    108. Familial expression of anti-Escherichia coli outer membrane porin C in relatives of patients with Crohn's disease. Gastroenterology. 2006 Apr; 130(4):1078-85. Mei L, Targan SR, Landers CJ, Dutridge D, Ippoliti A, Vasiliauskas EA, Papadakis KA, Fleshner PR, Rotter JI, Yang H. PMID: 16618402.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    109. Serum immune responses predict rapid disease progression among children with Crohn's disease: immune responses predict disease progression. Am J Gastroenterol. 2006 Feb; 101(2):360-7. Dubinsky MC, Lin YC, Dutridge D, Picornell Y, Landers CJ, Farrior S, Wrobel I, Quiros A, Vasiliauskas EA, Grill B, Israel D, Bahar R, Christie D, Wahbeh G, Silber G, Dallazadeh S, Shah P, Thomas D, Kelts D, Hershberg RM, Elson CO, Targan SR, Taylor KD, Rotter JI, Yang H. PMID: 16454844.
      View in: PubMed   Mentions: 78     Fields:    Translation:Humans
    110. Treatment with infliximab is associated with increased markers of bone formation in patients with Crohn's disease. J Clin Gastroenterol. 2006 Jan; 40(1):55-63. Abreu MT, Geller JL, Vasiliauskas EA, Kam LY, Vora P, Martyak LA, Yang H, Hu B, Lin YC, Keenan G, Price J, Landers CJ, Adams JS, Targan SR. PMID: 16340635.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    111. Multiparameter analysis of immunogenetic mechanisms in clinical diagnosis and management of inflammatory bowel disease. Adv Exp Med Biol. 2006; 579:209-18. Braun J, Targan SR. PMID: 16620020.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    112. Elevated platelet count before ileal pouch-anal anastomosis for ulcerative colitis is associated with the development of chronic pouchitis. Am Surg. 2005 Oct; 71(10):821-6. Okon A, Dubinsky M, Vasiliauskas EA, Papadakis KA, Ippoliti A, Targan SR, Fleshner PR. PMID: 16468527.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    113. Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol. 2005 Sep; 19 Suppl A:5A-36A. Silverberg MS, Satsangi J, Ahmad T, Arnott ID, Bernstein CN, Brant SR, Caprilli R, Colombel JF, Gasche C, Geboes K, Jewell DP, Karban A, Loftus EV, Peña AS, Riddell RH, Sachar DB, Schreiber S, Steinhart AH, Targan SR, Vermeire S, Warren BF. PMID: 16151544.
      View in: PubMed   Mentions: 587     Fields:    Translation:Humans
    114. Defects in mucosal immunity leading to ulcerative colitis. Immunol Rev. 2005 Aug; 206:296-305. Targan SR, Karp LC. PMID: 16048556.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimals
    115. Serologic responses in indeterminate colitis patients before ileal pouch-anal anastomosis may determine those at risk for continuous pouch inflammation. Dis Colon Rectum. 2005 Jun; 48(6):1254-62. Hui T, Landers C, Vasiliauskas E, Abreu M, Dubinsky M, Papadakis KA, Price J, Lin YC, Huiying Y, Targan S, Fleshner P. PMID: 15868228.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    116. Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease. Gastroenterology. 2005 Jun; 128(7):2020-8. Targan SR, Landers CJ, Yang H, Lodes MJ, Cong Y, Papadakis KA, Vasiliauskas E, Elson CO, Hershberg RM. PMID: 15940634.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansAnimals
    117. Dominant role for TL1A/DR3 pathway in IL-12 plus IL-18-induced IFN-gamma production by peripheral blood and mucosal CCR9+ T lymphocytes. J Immunol. 2005 Apr 15; 174(8):4985-90. Papadakis KA, Zhu D, Prehn JL, Landers C, Avanesyan A, Lafkas G, Targan SR. PMID: 15814728.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    118. LIGHT is constitutively expressed on T and NK cells in the human gut and can be induced by CD2-mediated signaling. J Immunol. 2005 Jan 15; 174(2):646-53. Cohavy O, Zhou J, Ware CF, Targan SR. PMID: 15634882.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    119. Safety and efficacy of adalimumab (D2E7) in Crohn's disease patients with an attenuated response to infliximab. Am J Gastroenterol. 2005 Jan; 100(1):75-9. Papadakis KA, Shaye OA, Vasiliauskas EA, Ippoliti A, Dubinsky MC, Birt J, Paavola J, Lee SK, Price J, Targan SR, Abreu MT. PMID: 15654784.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    120. Expression and regulation of the chemokine receptor CXCR3 on lymphocytes from normal and inflammatory bowel disease mucosa. Inflamm Bowel Dis. 2004 Nov; 10(6):778-88. Papadakis KA, Prehn J, Zhu D, Landers C, Gaiennie J, Fleshner PR, Targan SR. PMID: 15626897.
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    121. Early hepatic nodular hyperplasia and submicroscopic fibrosis associated with 6-thioguanine therapy in inflammatory bowel disease. Am J Surg Pathol. 2004 Sep; 28(9):1204-11. Geller SA, Dubinsky MC, Poordad FF, Vasiliauskas EA, Cohen AH, Abreu MT, Tran T, Martin P, Vierling JM, Targan SR. PMID: 15316320.
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    122. High-level serum antibodies to bacterial antigens are associated with antibiotic-induced clinical remission in Crohn's disease: a pilot study. Dig Dis Sci. 2004 Aug; 49(7-8):1280-6. Mow WS, Landers CJ, Steinhart AH, Feagan BG, Croitoru K, Seidman E, Greenberg GR, Targan SR. PMID: 15387358.
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    123. The spectrum of gastrointestinal toxicity and effect on disease activity of selective cyclooxygenase-2 inhibitors in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2004 Jul; 10(4):352-6. Matuk R, Crawford J, Abreu MT, Targan SR, Vasiliauskas EA, Papadakis KA. PMID: 15475742.
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    124. LIGHT expression by mucosal T cells may regulate IFN-gamma expression in the intestine. J Immunol. 2004 Jul 01; 173(1):251-8. Cohavy O, Zhou J, Granger SW, Ware CF, Targan SR. PMID: 15210782.
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    125. Potential role for TL1A, the new TNF-family member and potent costimulator of IFN-gamma, in mucosal inflammation. Clin Immunol. 2004 Jul; 112(1):66-77. Prehn JL, Mehdizadeh S, Landers CJ, Luo X, Cha SC, Wei P, Targan SR. PMID: 15207783.
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    126. A pilot study of adalimumab in infliximab-allergic patients. Inflamm Bowel Dis. 2004 Jul; 10(4):333-8. Youdim A, Vasiliauskas EA, Targan SR, Papadakis KA, Ippoliti A, Dubinsky MC, Lechago J, Paavola J, Loane J, Lee SK, Gaiennie J, Smith K, Do J, Abreu MT. PMID: 15475739.
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    127. TL1A synergizes with IL-12 and IL-18 to enhance IFN-gamma production in human T cells and NK cells. J Immunol. 2004 Jun 01; 172(11):7002-7. Papadakis KA, Prehn JL, Landers C, Han Q, Luo X, Cha SC, Wei P, Targan SR. PMID: 15153521.
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    128. High incidence of anergy in inflammatory bowel disease patients limits the usefulness of PPD screening before infliximab therapy. Clin Gastroenterol Hepatol. 2004 Apr; 2(4):309-13. Mow WS, Abreu-Martin MT, Papadakis KA, Pitchon HE, Targan SR, Vasiliauskas EA. PMID: 15067625.
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    129. Association of antibody responses to microbial antigens and complications of small bowel Crohn's disease. Gastroenterology. 2004 Feb; 126(2):414-24. Mow WS, Vasiliauskas EA, Lin YC, Fleshner PR, Papadakis KA, Taylor KD, Landers CJ, Abreu-Martin MT, Rotter JI, Yang H, Targan SR. PMID: 14762777.
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    130. Initial experience with wireless capsule enteroscopy in the diagnosis and management of inflammatory bowel disease. Clin Gastroenterol Hepatol. 2004 Jan; 2(1):31-40. Mow WS, Lo SK, Targan SR, Dubinsky MC, Treyzon L, Abreu-Martin MT, Papadakis KA, Vasiliauskas EA. PMID: 15017630.
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    131. 6-thioguanine can cause serious liver injury in inflammatory bowel disease patients. Gastroenterology. 2003 Aug; 125(2):298-303. Dubinsky MC, Vasiliauskas EA, Singh H, Abreu MT, Papadakis KA, Tran T, Martin P, Vierling JM, Geller SA, Targan SR, Poordad FF. PMID: 12891528.
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    132. CC chemokine receptor 9 expression defines a subset of peripheral blood lymphocytes with mucosal T cell phenotype and Th1 or T-regulatory 1 cytokine profile. J Immunol. 2003 Jul 01; 171(1):159-65. Papadakis KA, Landers C, Prehn J, Kouroumalis EA, Moreno ST, Gutierrez-Ramos JC, Hodge MR, Targan SR. PMID: 12816994.
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    133. Thioguanine: a potential alternate thiopurine for IBD patients allergic to 6-mercaptopurine or azathioprine. Am J Gastroenterol. 2003 May; 98(5):1058-63. Dubinsky MC, Feldman EJ, Abreu MT, Targan SR, Vasiliauskas EA. PMID: 12809828.
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    134. Challenges in IBD Research: updating the scientific agendas. Inflamm Bowel Dis. 2003 May; 9(3):137-53. Elson CO, Sartor RB, Targan SR, Sandborn WJ. PMID: 12792219.
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    135. CD2 mediates activation of the IFN-gamma intronic STAT binding region in mucosal T cells. Eur J Immunol. 2003 May; 33(5):1152-62. Gonsky R, Deem RL, Young HA, Targan SR. PMID: 12731040.
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    136. A novel NOD2/CARD15 haplotype conferring risk for Crohn disease in Ashkenazi Jews. Am J Hum Genet. 2003 Mar; 72(3):509-18. Sugimura K, Taylor KD, Lin YC, Hang T, Wang D, Tang YM, Fischel-Ghodsian N, Targan SR, Rotter JI, Yang H. PMID: 12577202.
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    137. Anti-CD2O chimeric monoclonal antibody (rituximab) treatment of immune-mediated thrombocytopenia associated with Crohn's disease. Gastroenterology. 2003 Feb; 124(2):583. Papadakis KA, Rosenbloom B, Targan SR. PMID: 12557172.
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    138. Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease. Gastroenterology. 2002 Sep; 123(3):679-88. Abreu MT, Taylor KD, Lin YC, Hang T, Gaiennie J, Landers CJ, Vasiliauskas EA, Kam LY, Rojany M, Papadakis KA, Rotter JI, Targan SR, Yang H. PMID: 12198692.
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    139. Selected loss of tolerance evidenced by Crohn's disease-associated immune responses to auto- and microbial antigens. Gastroenterology. 2002 Sep; 123(3):689-99. Landers CJ, Cohavy O, Misra R, Yang H, Lin YC, Braun J, Targan SR. PMID: 12198693.
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    140. Biologic therapy of inflammatory bowel disease. Gastroenterology. 2002 May; 122(6):1592-608. Sandborn WJ, Targan SR. PMID: 12016425.
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    141. 6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease. Gastroenterology. 2002 Apr; 122(4):904-15. Dubinsky MC, Yang H, Hassard PV, Seidman EG, Kam LY, Abreu MT, Targan SR, Vasiliauskas EA. PMID: 11910342.
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    142. Biology of inflammation in Crohn's disease: mechanisms of action of anti-TNF-a therapy. Can J Gastroenterol. 2000 Sep; 14 Suppl C:13C-16C. Targan SR. PMID: 11023555.
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