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Goodridge, Helen Sara

Title(s)Associate Adjunct Professor, Medicine
SchoolDigestive Diseases
Phone(310) 423-7582
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    Collapse Research 
    Collapse Research Activities and Funding
    Monocyte Production by Bone Marrow Progenitors
    NIH/NIAID R01AI134987May 15, 2018 - Apr 30, 2023
    Role: Principal Investigator
    Effects of Microbial Exposure on Myelopoiesis
    NIH/NIAID R21AI082379Sep 18, 2010 - Aug 31, 2012
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kang S, Moser VA, Svendsen CN, Goodridge HS. Rejuvenating the blood and bone marrow to slow aging-associated cognitive decline and Alzheimer's disease. Commun Biol. 2020 Feb 13; 3(1):69. PMID: 32054965.
      View in: PubMed
    2. Wolf AA, Yáñez A, Barman PK, Goodridge HS. The Ontogeny of Monocyte Subsets. Front Immunol. 2019; 10:1642. PMID: 31379841.
      View in: PubMed
    3. Ehrhardt N, Cui J, Dagdeviren S, Saengnipanthkul S, Goodridge HS, Kim JK, Lantier L, Guo X, Chen YI, Raffel LJ, Buchanan TA, Hsueh WA, Rotter JI, Goodarzi MO, Péterfy M. Adiposity-Independent Effects of Aging on Insulin Sensitivity and Clearance in Mice and Humans. Obesity (Silver Spring). 2019 03; 27(3):434-443. PMID: 30801985.
      View in: PubMed
    4. Das MM, Godoy M, Chen S, Moser VA, Avalos P, Roxas KM, Dang I, Yáñez A, Zhang W, Bresee C, Arditi M, Liu GY, Svendsen CN, Goodridge HS. Young bone marrow transplantation preserves learning and memory in old mice. Commun Biol. 2019; 2:73. PMID: 30820468.
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    5. Saylor J, Ma Z, Goodridge HS, Huang F, Cress AE, Pandol SJ, Shiao SL, Vidal AC, Wu L, Nickols NG, Gertych A, Knudsen BS. Spatial Mapping of Myeloid Cells and Macrophages by Multiplexed Tissue Staining. Front Immunol. 2018; 9:2925. PMID: 30619287.
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    6. Crupi AN, Nunnelee JS, Taylor DJ, Thomas A, Vit JP, Riera CE, Gottlieb RA, Goodridge HS. Oxidative muscles have better mitochondrial homeostasis than glycolytic muscles throughout life and maintain mitochondrial function during aging. Aging (Albany NY). 2018 11 18; 10(11):3327-3352. PMID: 30449736.
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    7. Yáñez A, Goodridge HS. Identification and Isolation of Oligopotent and Lineage-committed Myeloid Progenitors from Mouse Bone Marrow. J Vis Exp. 2018 07 29; (137). PMID: 30102291.
      View in: PubMed
    8. Wolf AA, Goodridge HS. Mast Cells Reveal Their Past Selves. Immunity. 2018 06 19; 48(6):1065-1067. PMID: 29924968.
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    9. McGonigle TA, Dwyer AR, Greenland EL, Scott NM, Carter KW, Keane KN, Newsholme P, Goodridge HS, Pixley FJ, Hart PH. Reticulon-1 and Reduced Migration toward Chemoattractants by Macrophages Differentiated from the Bone Marrow of Ultraviolet-Irradiated and Ultraviolet-Chimeric Mice. J Immunol. 2018 01 01; 200(1):260-270. PMID: 29167231.
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    10. Yáñez A, Coetzee SG, Olsson A, Muench DE, Berman BP, Hazelett DJ, Salomonis N, Grimes HL, Goodridge HS. Granulocyte-Monocyte Progenitors and Monocyte-Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes. Immunity. 2017 11 21; 47(5):890-902.e4. PMID: 29166589.
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    11. McGonigle TA, Dwyer AR, Greenland EL, Scott NM, Keane KN, Newsholme P, Goodridge HS, Zon LI, Pixley FJ, Hart PH. PGE2 pulsing of murine bone marrow cells reduces migration of daughter monocytes/macrophages in vitro and in vivo. Exp Hematol. 2017 12; 56:64-68. PMID: 28822771.
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    12. Yáñez A, Goodridge HS, Grimes HL. Counting the cost of lineage decisions. Nat Immunol. 2017 07 19; 18(8):872-873. PMID: 28722717.
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    13. McGonigle TA, Keane KN, Ghaly S, Carter KW, Anderson D, Scott NM, Goodridge HS, Dwyer A, Greenland E, Pixley FJ, Newsholme P, Hart PH. UV Irradiation of Skin Enhances Glycolytic Flux and Reduces Migration Capabilities in Bone Marrow-Differentiated Dendritic Cells. Am J Pathol. 2017 Sep; 187(9):2046-2059. PMID: 28708972.
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    14. Hassanzadeh-Kiabi N, Yáñez A, Dang I, Martins GA, Underhill DM, Goodridge HS. Autocrine Type I IFN Signaling in Dendritic Cells Stimulated with Fungal ß-Glucans or Lipopolysaccharide Promotes CD8 T Cell Activation. J Immunol. 2017 01 01; 198(1):375-382. PMID: 27872213.
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    15. Goodridge HS, Ahmed SS, Curtis N, Kollmann TR, Levy O, Netea MG, Pollard AJ, van Crevel R, Wilson CB. Harnessing the beneficial heterologous effects of vaccination. Nat Rev Immunol. 2016 06; 16(6):392-400. PMID: 27157064.
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    16. O'Rourke JG, Bogdanik L, Yáñez A, Lall D, Wolf AJ, Muhammad AK, Ho R, Carmona S, Vit JP, Zarrow J, Kim KJ, Bell S, Harms MB, Miller TM, Dangler CA, Underhill DM, Goodridge HS, Lutz CM, Baloh RH. C9orf72 is required for proper macrophage and microglial function in mice. Science. 2016 Mar 18; 351(6279):1324-9. PMID: 26989253.
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    17. Megías J, Martínez A, Yáñez A, Goodridge HS, Gozalbo D, Gil ML. TLR2, TLR4 and Dectin-1 signalling in hematopoietic stem and progenitor cells determines the antifungal phenotype of the macrophages they produce. Microbes Infect. 2016 05; 18(5):354-63. PMID: 26828664.
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    18. Yáñez A, Goodridge HS. Interferon regulatory factor 8 and the regulation of neutrophil, monocyte, and dendritic cell production. Curr Opin Hematol. 2016 Jan; 23(1):11-7. PMID: 26554887.
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    19. Freedman TS, Tan YX, Skrzypczynska KM, Manz BN, Sjaastad FV, Goodridge HS, Lowell CA, Weiss A. LynA regulates an inflammation-sensitive signaling checkpoint in macrophages. Elife. 2015 Oct 30; 4. PMID: 26517880.
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    20. Yáñez A, Ng MY, Hassanzadeh-Kiabi N, Goodridge HS. IRF8 acts in lineage-committed rather than oligopotent progenitors to control neutrophil vs monocyte production. Blood. 2015 Feb 26; 125(9):1452-9. PMID: 25597637.
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    21. Khosravi A, Yáñez A, Price JG, Chow A, Merad M, Goodridge HS, Mazmanian SK. Gut microbiota promote hematopoiesis to control bacterial infection. Cell Host Microbe. 2014 Mar 12; 15(3):374-81. PMID: 24629343.
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    22. Goodridge HS. Editorial: Bone marrow progenitors share their experiences with their offspring. J Leukoc Biol. 2014 Feb; 95(2):201-4. PMID: 24482486.
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    23. Goodridge HS. Induced pluripotent stem cell-derived myeloid phagocytes: disease modeling and therapeutic applications. Drug Discov Today. 2014 Jun; 19(6):774-80. PMID: 24445266.
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    24. Yáñez A, Goodridge HS, Gozalbo D, Gil ML. TLRs control hematopoiesis during infection. Eur J Immunol. 2013 Oct; 43(10):2526-33. PMID: 24122753.
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    25. Yáñez A, Hassanzadeh-Kiabi N, Ng MY, Megías J, Subramanian A, Liu GY, Underhill DM, Gil ML, Goodridge HS. Detection of a TLR2 agonist by hematopoietic stem and progenitor cells impacts the function of the macrophages they produce. Eur J Immunol. 2013 Aug; 43(8):2114-25. PMID: 23661549.
      View in: PubMed
    26. Goodridge HS, Underhill DM, Touret N. Mechanisms of Fc receptor and dectin-1 activation for phagocytosis. Traffic. 2012 Aug; 13(8):1062-71. PMID: 22624959.
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    27. Underhill DM, Goodridge HS. Information processing during phagocytosis. Nat Rev Immunol. 2012 Jun 15; 12(7):492-502. PMID: 22699831.
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    28. Harnett W, Goodridge HS, Allen JM, Harnett M. Receptor usage by the Acanthocheilonema viteae-derived immunomodulator, ES-62. Exp Parasitol. 2012 Sep; 132(1):97-102. PMID: 21925176.
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    29. Goodridge HS, Reyes CN, Becker CA, Katsumoto TR, Ma J, Wolf AJ, Bose N, Chan AS, Magee AS, Danielson ME, Weiss A, Vasilakos JP, Underhill DM. Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. Nature. 2011 Apr 28; 472(7344):471-5. PMID: 21525931.
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    30. Okwan-Duodu D, Datta V, Shen XZ, Goodridge HS, Bernstein EA, Fuchs S, Liu GY, Bernstein KE. Angiotensin-converting enzyme overexpression in mouse myelomonocytic cells augments resistance to Listeria and methicillin-resistant Staphylococcus aureus. J Biol Chem. 2010 Dec 10; 285(50):39051-60. PMID: 20937811.
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    31. Gueller S, Goodridge HS, Niebuhr B, Xing H, Koren-Michowitz M, Serve H, Underhill DM, Brandts CH, Koeffler HP. Adaptor protein Lnk inhibits c-Fms-mediated macrophage function. J Leukoc Biol. 2010 Oct; 88(4):699-706. PMID: 20571037.
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    32. Shimada T, Park BG, Wolf AJ, Brikos C, Goodridge HS, Becker CA, Reyes CN, Miao EA, Aderem A, Götz F, Liu GY, Underhill DM. Staphylococcus aureus evades lysozyme-based peptidoglycan digestion that links phagocytosis, inflammasome activation, and IL-1beta secretion. Cell Host Microbe. 2010 Jan 21; 7(1):38-49. PMID: 20114027.
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    33. Goodridge HS, Wolf AJ, Underhill DM. Beta-glucan recognition by the innate immune system. Immunol Rev. 2009 Jul; 230(1):38-50. PMID: 19594628.
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    34. Goodridge HS, Shimada T, Wolf AJ, Hsu YM, Becker CA, Lin X, Underhill DM. Differential use of CARD9 by dectin-1 in macrophages and dendritic cells. J Immunol. 2009 Jan 15; 182(2):1146-54. PMID: 19124758.
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    35. Krejci P, Salazar L, Goodridge HS, Kashiwada TA, Schibler MJ, Jelinkova P, Thompson LM, Wilcox WR. STAT1 and STAT3 do not participate in FGF-mediated growth arrest in chondrocytes. J Cell Sci. 2008 Feb 01; 121(Pt 3):272-81. PMID: 18198189.
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    36. Goodridge HS, Underhill DM. Fungal Recognition by TLR2 and Dectin-1. Handb Exp Pharmacol. 2008; (183):87-109. PMID: 18071656.
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    37. Goodridge HS, Simmons RM, Underhill DM. Dectin-1 stimulation by Candida albicans yeast or zymosan triggers NFAT activation in macrophages and dendritic cells. J Immunol. 2007 Mar 01; 178(5):3107-15. PMID: 17312158.
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    38. Goodridge HS, McGuiness S, Houston KM, Egan CA, Al-Riyami L, Alcocer MJ, Harnett MM, Harnett W. Phosphorylcholine mimics the effects of ES-62 on macrophages and dendritic cells. Parasite Immunol. 2007 Mar; 29(3):127-37. PMID: 17266740.
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    39. Underhill DM, Goodridge HS. The many faces of ITAMs. Trends Immunol. 2007 Feb; 28(2):66-73. PMID: 17197236.
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    40. Sester DP, Brion K, Trieu A, Goodridge HS, Roberts TL, Dunn J, Hume DA, Stacey KJ, Sweet MJ. CpG DNA activates survival in murine macrophages through TLR9 and the phosphatidylinositol 3-kinase-Akt pathway. J Immunol. 2006 Oct 01; 177(7):4473-80. PMID: 16982883.
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    41. Kean DE, Goodridge HS, McGuinness S, Harnett MM, Alcocer MJ, Harnett W. Differential polarization of immune responses by plant 2S seed albumins, Ber e 1, and SFA8. J Immunol. 2006 Aug 01; 177(3):1561-6. PMID: 16849463.
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    42. Goodridge HS, Stepek G, Harnett W, Harnett MM. Signalling mechanisms underlying subversion of the immune response by the filarial nematode secreted product ES-62. Immunology. 2005 Jul; 115(3):296-304. PMID: 15946247.
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    43. Goodridge HS, Harnett MM. Introduction to immune cell signalling. Parasitology. 2005; 130 Suppl:S3-9. PMID: 16281990.
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    44. Harnett W, Goodridge HS, Harnett MM. Subversion of immune cell signal transduction pathways by the secreted filarial nematode product, ES-62. Parasitology. 2005; 130 Suppl:S63-8. PMID: 16281993.
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    45. Goodridge HS, Marshall FA, Else KJ, Houston KM, Egan C, Al-Riyami L, Liew FY, Harnett W, Harnett MM. Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine-containing secreted product, ES-62. J Immunol. 2005 Jan 01; 174(1):284-93. PMID: 15611251.
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    46. Goodridge HS, Deehan MR, Harnett W, Harnett MM. Subversion of immunological signalling by a filarial nematode phosphorylcholine-containing secreted product. Cell Signal. 2005 Jan; 17(1):11-6. PMID: 15451020.
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    47. Goodridge HS, Marshall FA, Wilson EH, Houston KM, Liew FY, Harnett MM, Harnett W. In vivo exposure of murine dendritic cell and macrophage bone marrow progenitors to the phosphorylcholine-containing filarial nematode glycoprotein ES-62 polarizes their differentiation to an anti-inflammatory phenotype. Immunology. 2004 Dec; 113(4):491-8. PMID: 15554927.
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    48. Stepek G, Houston KM, Goodridge HS, Devaney E, Harnett W. Stage-specific and species-specific differences in the production of the mRNA and protein for the filarial nematode secreted product, ES-62. Parasitology. 2004 Jan; 128(Pt 1):91-8. PMID: 15002908.
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    49. Wilson EH, Katz E, Goodridge HS, Harnett MM, Harnett W. In vivo activation of murine peritoneal B1 cells by the filarial nematode phosphorylcholine-containing glycoprotein ES-62. Parasite Immunol. 2003 Aug-Sep; 25(8-9):463-6. PMID: 14651594.
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    50. Goodridge HS, Harnett W, Liew FY, Harnett MM. Differential regulation of interleukin-12 p40 and p35 induction via Erk mitogen-activated protein kinase-dependent and -independent mechanisms and the implications for bioactive IL-12 and IL-23 responses. Immunology. 2003 Jul; 109(3):415-25. PMID: 12807488.
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    51. Smith RE, Patel V, Seatter SD, Deehan MR, Brown MH, Brooke GP, Goodridge HS, Howard CJ, Rigley KP, Harnett W, Harnett MM. A novel MyD-1 (SIRP-1alpha) signaling pathway that inhibits LPS-induced TNFalpha production by monocytes. Blood. 2003 Oct 01; 102(7):2532-40. PMID: 12805067.
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    52. Deehan MR, Goodridge HS, Blair D, Lochnit G, Dennis RD, Geyer R, Harnett MM, Harnett W. Immunomodulatory properties of Ascaris suum glycosphingolipids - phosphorylcholine and non-phosphorylcholine-dependent effects. Parasite Immunol. 2002 Sep-Oct; 24(9-10):463-9. PMID: 12654088.
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    53. Goodridge HS, Wilson EH, Harnett W, Campbell CC, Harnett MM, Liew FY. Modulation of macrophage cytokine production by ES-62, a secreted product of the filarial nematode Acanthocheilonema viteae. J Immunol. 2001 Jul 15; 167(2):940-5. PMID: 11441102.
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    54. Feng GJ, Goodridge HS, Harnett MM, Wei XQ, Nikolaev AV, Higson AP, Liew FY. Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase. J Immunol. 1999 Dec 15; 163(12):6403-12. PMID: 10586030.
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