Loading...

Helen Sara Goodridge

Title(s)Associate Adjunct Professor, Medicine
SchoolMedicine
Address760 Westwood Plaza 32-144
Los Angeles CA 90024
Phone(310) 423-7582
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Monocyte Production by Bone Marrow Progenitors
    NIH/NIAID R01AI134987May 15, 2018 - Apr 30, 2023
    Role: Principal Investigator
    Effects of Microbial Exposure on Myelopoiesis
    NIH/NIAID R21AI082379Sep 18, 2010 - Aug 31, 2012
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cell type-specific immune dysregulation in severely ill COVID-19 patients. medRxiv. 2020 Jul 24. Yao C, Bora SA, Parimon T, Zaman T, Friedman OA, Palatinus JA, Surapaneni NS, Matusov YP, Cerro Chiang G, Kassar AG, Patel N, Green CE, Aziz AW, Suri H, Suda J, Lopez AA, Martins GA, Stripp BR, Gharib SA, Goodridge HS, Chen P. PMID: 32743611.
      View in: PubMed   Mentions:
    2. TLR2 and Dectin-1 Signaling in Mouse Hematopoietic Stem and Progenitor Cells Impacts the Ability of the Antigen Presenting Cells They Produce to Activate CD4 T Cells. Cells. 2020 May 25; 9(5). Martínez A, Bono C, Gozalbo D, Goodridge HS, Gil ML, Yáñez A. PMID: 32466296.
      View in: PubMed   Mentions:    Fields:    
    3. Immunosuppressive Functions of M2 Macrophages Derived from iPSCs of Patients with ALS and Healthy Controls. iScience. 2020 Jun 26; 23(6):101192. Zhao W, Beers DR, Thonhoff JR, Thome AD, Faridar A, Wang J, Wen S, Ornelas L, Sareen D, Goodridge HS, Svendsen CN, Appel SH. PMID: 32521508.
      View in: PubMed   Mentions:
    4. Rejuvenating the blood and bone marrow to slow aging-associated cognitive decline and Alzheimer's disease. Commun Biol. 2020 02 13; 3(1):69. Kang S, Moser VA, Svendsen CN, Goodridge HS. PMID: 32054965.
      View in: PubMed   Mentions:
    5. The Ontogeny of Monocyte Subsets. Front Immunol. 2019; 10:1642. Wolf AA, Yáñez A, Barman PK, Goodridge HS. PMID: 31379841.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    6. Adiposity-Independent Effects of Aging on Insulin Sensitivity and Clearance in Mice and Humans. Obesity (Silver Spring). 2019 03; 27(3):434-443. Ehrhardt N, Cui J, Dagdeviren S, Saengnipanthkul S, Goodridge HS, Kim JK, Lantier L, Guo X, Chen YI, Raffel LJ, Buchanan TA, Hsueh WA, Rotter JI, Goodarzi MO, Péterfy M. PMID: 30801985.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    7. Young bone marrow transplantation preserves learning and memory in old mice. Commun Biol. 2019; 2:73. Das MM, Godoy M, Chen S, Moser VA, Avalos P, Roxas KM, Dang I, Yáñez A, Zhang W, Bresee C, Arditi M, Liu GY, Svendsen CN, Goodridge HS. PMID: 30820468.
      View in: PubMed   Mentions:
    8. Spatial Mapping of Myeloid Cells and Macrophages by Multiplexed Tissue Staining. Front Immunol. 2018; 9:2925. Saylor J, Ma Z, Goodridge HS, Huang F, Cress AE, Pandol SJ, Shiao SL, Vidal AC, Wu L, Nickols NG, Gertych A, Knudsen BS. PMID: 30619287.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    9. Oxidative muscles have better mitochondrial homeostasis than glycolytic muscles throughout life and maintain mitochondrial function during aging. Aging (Albany NY). 2018 11 18; 10(11):3327-3352. Crupi AN, Nunnelee JS, Taylor DJ, Thomas A, Vit JP, Riera CE, Gottlieb RA, Goodridge HS. PMID: 30449736.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    10. Identification and Isolation of Oligopotent and Lineage-committed Myeloid Progenitors from Mouse Bone Marrow. J Vis Exp. 2018 07 29; (137). Yáñez A, Goodridge HS. PMID: 30102291.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    11. Mast Cells Reveal Their Past Selves. Immunity. 2018 06 19; 48(6):1065-1067. Wolf AA, Goodridge HS. PMID: 29924968.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    12. Reticulon-1 and Reduced Migration toward Chemoattractants by Macrophages Differentiated from the Bone Marrow of Ultraviolet-Irradiated and Ultraviolet-Chimeric Mice. J Immunol. 2018 01 01; 200(1):260-270. McGonigle TA, Dwyer AR, Greenland EL, Scott NM, Carter KW, Keane KN, Newsholme P, Goodridge HS, Pixley FJ, Hart PH. PMID: 29167231.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    13. Granulocyte-Monocyte Progenitors and Monocyte-Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes. Immunity. 2017 11 21; 47(5):890-902.e4. Yáñez A, Coetzee SG, Olsson A, Muench DE, Berman BP, Hazelett DJ, Salomonis N, Grimes HL, Goodridge HS. PMID: 29166589.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    14. PGE2 pulsing of murine bone marrow cells reduces migration of daughter monocytes/macrophages in vitro and in vivo. Exp Hematol. 2017 12; 56:64-68. McGonigle TA, Dwyer AR, Greenland EL, Scott NM, Keane KN, Newsholme P, Goodridge HS, Zon LI, Pixley FJ, Hart PH. PMID: 28822771.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    15. Counting the cost of lineage decisions. Nat Immunol. 2017 07 19; 18(8):872-873. Yáñez A, Goodridge HS, Grimes HL. PMID: 28722717.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    16. UV Irradiation of Skin Enhances Glycolytic Flux and Reduces Migration Capabilities in Bone Marrow-Differentiated Dendritic Cells. Am J Pathol. 2017 Sep; 187(9):2046-2059. McGonigle TA, Keane KN, Ghaly S, Carter KW, Anderson D, Scott NM, Goodridge HS, Dwyer A, Greenland E, Pixley FJ, Newsholme P, Hart PH. PMID: 28708972.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    17. Autocrine Type I IFN Signaling in Dendritic Cells Stimulated with Fungal ß-Glucans or Lipopolysaccharide Promotes CD8 T Cell Activation. J Immunol. 2017 01 01; 198(1):375-382. Hassanzadeh-Kiabi N, Yáñez A, Dang I, Martins GA, Underhill DM, Goodridge HS. PMID: 27872213.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    18. Harnessing the beneficial heterologous effects of vaccination. Nat Rev Immunol. 2016 06; 16(6):392-400. Goodridge HS, Ahmed SS, Curtis N, Kollmann TR, Levy O, Netea MG, Pollard AJ, van Crevel R, Wilson CB. PMID: 27157064.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsPHPublic Health
    19. C9orf72 is required for proper macrophage and microglial function in mice. Science. 2016 Mar 18; 351(6279):1324-9. O'Rourke JG, Bogdanik L, Yáñez A, Lall D, Wolf AJ, Muhammad AK, Ho R, Carmona S, Vit JP, Zarrow J, Kim KJ, Bell S, Harms MB, Miller TM, Dangler CA, Underhill DM, Goodridge HS, Lutz CM, Baloh RH. PMID: 26989253.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansAnimalsCells
    20. TLR2, TLR4 and Dectin-1 signalling in hematopoietic stem and progenitor cells determines the antifungal phenotype of the macrophages they produce. Microbes Infect. 2016 05; 18(5):354-63. Megías J, Martínez A, Yáñez A, Goodridge HS, Gozalbo D, Gil ML. PMID: 26828664.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    21. Interferon regulatory factor 8 and the regulation of neutrophil, monocyte, and dendritic cell production. Curr Opin Hematol. 2016 Jan; 23(1):11-7. Yáñez A, Goodridge HS. PMID: 26554887.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    22. LynA regulates an inflammation-sensitive signaling checkpoint in macrophages. Elife. 2015 Oct 30; 4. Freedman TS, Tan YX, Skrzypczynska KM, Manz BN, Sjaastad FV, Goodridge HS, Lowell CA, Weiss A. PMID: 26517880.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    23. IRF8 acts in lineage-committed rather than oligopotent progenitors to control neutrophil vs monocyte production. Blood. 2015 Feb 26; 125(9):1452-9. Yáñez A, Ng MY, Hassanzadeh-Kiabi N, Goodridge HS. PMID: 25597637.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    24. Gut microbiota promote hematopoiesis to control bacterial infection. . 2014 Mar 12; 15(3):374-81. Khosravi A, Yáñez A, Price JG, Chow A, Merad M, Goodridge HS, Mazmanian SK. PMID: 24629343.
      View in: PubMed   Mentions:
    25. Editorial: Bone marrow progenitors share their experiences with their offspring. J Leukoc Biol. 2014 Feb; 95(2):201-4. Goodridge HS. PMID: 24482486.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    26. Induced pluripotent stem cell-derived myeloid phagocytes: disease modeling and therapeutic applications. Drug Discov Today. 2014 Jun; 19(6):774-80. Goodridge HS. PMID: 24445266.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    27. TLRs control hematopoiesis during infection. Eur J Immunol. 2013 Oct; 43(10):2526-33. Yáñez A, Goodridge HS, Gozalbo D, Gil ML. PMID: 24122753.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    28. Detection of a TLR2 agonist by hematopoietic stem and progenitor cells impacts the function of the macrophages they produce. Eur J Immunol. 2013 Aug; 43(8):2114-25. Yáñez A, Hassanzadeh-Kiabi N, Ng MY, Megías J, Subramanian A, Liu GY, Underhill DM, Gil ML, Goodridge HS. PMID: 23661549.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    29. Mechanisms of Fc receptor and dectin-1 activation for phagocytosis. Traffic. 2012 Aug; 13(8):1062-71. Goodridge HS, Underhill DM, Touret N. PMID: 22624959.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    30. Information processing during phagocytosis. Nat Rev Immunol. 2012 Jun 15; 12(7):492-502. Underhill DM, Goodridge HS. PMID: 22699831.
      View in: PubMed   Mentions: 148     Fields:    Translation:HumansAnimalsCells
    31. Receptor usage by the Acanthocheilonema viteae-derived immunomodulator, ES-62. Exp Parasitol. 2012 Sep; 132(1):97-102. Harnett W, Goodridge HS, Allen JM, Harnett M. PMID: 21925176.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    32. Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. Nature. 2011 Apr 28; 472(7344):471-5. Goodridge HS, Reyes CN, Becker CA, Katsumoto TR, Ma J, Wolf AJ, Bose N, Chan AS, Magee AS, Danielson ME, Weiss A, Vasilakos JP, Underhill DM. PMID: 21525931.
      View in: PubMed   Mentions: 209     Fields:    Translation:HumansAnimalsCells
    33. Angiotensin-converting enzyme overexpression in mouse myelomonocytic cells augments resistance to Listeria and methicillin-resistant Staphylococcus aureus. J Biol Chem. 2010 Dec 10; 285(50):39051-60. Okwan-Duodu D, Datta V, Shen XZ, Goodridge HS, Bernstein EA, Fuchs S, Liu GY, Bernstein KE. PMID: 20937811.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    34. Adaptor protein Lnk inhibits c-Fms-mediated macrophage function. J Leukoc Biol. 2010 Oct; 88(4):699-706. Gueller S, Goodridge HS, Niebuhr B, Xing H, Koren-Michowitz M, Serve H, Underhill DM, Brandts CH, Koeffler HP. PMID: 20571037.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    35. Staphylococcus aureus evades lysozyme-based peptidoglycan digestion that links phagocytosis, inflammasome activation, and IL-1beta secretion. . 2010 Jan 21; 7(1):38-49. Shimada T, Park BG, Wolf AJ, Brikos C, Goodridge HS, Becker CA, Reyes CN, Miao EA, Aderem A, Götz F, Liu GY, Underhill DM. PMID: 20114027.
      View in: PubMed   Mentions:
    36. Beta-glucan recognition by the innate immune system. Immunol Rev. 2009 Jul; 230(1):38-50. Goodridge HS, Wolf AJ, Underhill DM. PMID: 19594628.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    37. Differential use of CARD9 by dectin-1 in macrophages and dendritic cells. J Immunol. 2009 Jan 15; 182(2):1146-54. Goodridge HS, Shimada T, Wolf AJ, Hsu YM, Becker CA, Lin X, Underhill DM. PMID: 19124758.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    38. STAT1 and STAT3 do not participate in FGF-mediated growth arrest in chondrocytes. J Cell Sci. 2008 Feb 01; 121(Pt 3):272-81. Krejci P, Salazar L, Goodridge HS, Kashiwada TA, Schibler MJ, Jelinkova P, Thompson LM, Wilcox WR. PMID: 18198189.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    39. Fungal Recognition by TLR2 and Dectin-1. Handb Exp Pharmacol. 2008; (183):87-109. Goodridge HS, Underhill DM. PMID: 18071656.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimals
    40. Dectin-1 stimulation by Candida albicans yeast or zymosan triggers NFAT activation in macrophages and dendritic cells. J Immunol. 2007 Mar 01; 178(5):3107-15. Goodridge HS, Simmons RM, Underhill DM. PMID: 17312158.
      View in: PubMed   Mentions: 136     Fields:    Translation:AnimalsCells
    41. Phosphorylcholine mimics the effects of ES-62 on macrophages and dendritic cells. Parasite Immunol. 2007 Mar; 29(3):127-37. Goodridge HS, McGuiness S, Houston KM, Egan CA, Al-Riyami L, Alcocer MJ, Harnett MM, Harnett W. PMID: 17266740.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    42. The many faces of ITAMs. Trends Immunol. 2007 Feb; 28(2):66-73. Underhill DM, Goodridge HS. PMID: 17197236.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    43. CpG DNA activates survival in murine macrophages through TLR9 and the phosphatidylinositol 3-kinase-Akt pathway. J Immunol. 2006 Oct 01; 177(7):4473-80. Sester DP, Brion K, Trieu A, Goodridge HS, Roberts TL, Dunn J, Hume DA, Stacey KJ, Sweet MJ. PMID: 16982883.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    44. Differential polarization of immune responses by plant 2S seed albumins, Ber e 1, and SFA8. J Immunol. 2006 Aug 01; 177(3):1561-6. Kean DE, Goodridge HS, McGuinness S, Harnett MM, Alcocer MJ, Harnett W. PMID: 16849463.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    45. Signalling mechanisms underlying subversion of the immune response by the filarial nematode secreted product ES-62. Immunology. 2005 Jul; 115(3):296-304. Goodridge HS, Stepek G, Harnett W, Harnett MM. PMID: 15946247.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    46. Introduction to immune cell signalling. Parasitology. 2005; 130 Suppl:S3-9. Goodridge HS, Harnett MM. PMID: 16281990.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    47. Subversion of immune cell signal transduction pathways by the secreted filarial nematode product, ES-62. Parasitology. 2005; 130 Suppl:S63-8. Harnett W, Goodridge HS, Harnett MM. PMID: 16281993.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    48. Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine-containing secreted product, ES-62. J Immunol. 2005 Jan 01; 174(1):284-93. Goodridge HS, Marshall FA, Else KJ, Houston KM, Egan C, Al-Riyami L, Liew FY, Harnett W, Harnett MM. PMID: 15611251.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells
    49. Subversion of immunological signalling by a filarial nematode phosphorylcholine-containing secreted product. Cell Signal. 2005 Jan; 17(1):11-6. Goodridge HS, Deehan MR, Harnett W, Harnett MM. PMID: 15451020.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    50. In vivo exposure of murine dendritic cell and macrophage bone marrow progenitors to the phosphorylcholine-containing filarial nematode glycoprotein ES-62 polarizes their differentiation to an anti-inflammatory phenotype. Immunology. 2004 Dec; 113(4):491-8. Goodridge HS, Marshall FA, Wilson EH, Houston KM, Liew FY, Harnett MM, Harnett W. PMID: 15554927.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    51. Stage-specific and species-specific differences in the production of the mRNA and protein for the filarial nematode secreted product, ES-62. Parasitology. 2004 Jan; 128(Pt 1):91-8. Stepek G, Houston KM, Goodridge HS, Devaney E, Harnett W. PMID: 15002908.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    52. In vivo activation of murine peritoneal B1 cells by the filarial nematode phosphorylcholine-containing glycoprotein ES-62. Parasite Immunol. 2003 Aug-Sep; 25(8-9):463-6. Wilson EH, Katz E, Goodridge HS, Harnett MM, Harnett W. PMID: 14651594.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    53. Differential regulation of interleukin-12 p40 and p35 induction via Erk mitogen-activated protein kinase-dependent and -independent mechanisms and the implications for bioactive IL-12 and IL-23 responses. Immunology. 2003 Jul; 109(3):415-25. Goodridge HS, Harnett W, Liew FY, Harnett MM. PMID: 12807488.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    54. A novel MyD-1 (SIRP-1alpha) signaling pathway that inhibits LPS-induced TNFalpha production by monocytes. Blood. 2003 Oct 01; 102(7):2532-40. Smith RE, Patel V, Seatter SD, Deehan MR, Brown MH, Brooke GP, Goodridge HS, Howard CJ, Rigley KP, Harnett W, Harnett MM. PMID: 12805067.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    55. Immunomodulatory properties of Ascaris suum glycosphingolipids - phosphorylcholine and non-phosphorylcholine-dependent effects. Parasite Immunol. 2002 Sep-Oct; 24(9-10):463-9. Deehan MR, Goodridge HS, Blair D, Lochnit G, Dennis RD, Geyer R, Harnett MM, Harnett W. PMID: 12654088.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    56. Modulation of macrophage cytokine production by ES-62, a secreted product of the filarial nematode Acanthocheilonema viteae. J Immunol. 2001 Jul 15; 167(2):940-5. Goodridge HS, Wilson EH, Harnett W, Campbell CC, Harnett MM, Liew FY. PMID: 11441102.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    57. Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase. J Immunol. 1999 Dec 15; 163(12):6403-12. Feng GJ, Goodridge HS, Harnett MM, Wei XQ, Nikolaev AV, Higson AP, Liew FY. PMID: 10586030.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    Helen's Networks
    Concepts (312)
    Derived automatically from this person's publications.
    _
    Co-Authors (13)
    People in Profiles who have published with this person.
    _
    Similar People (60)
    People who share similar concepts with this person.
    _
    Same Department
    Search Department
    _