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Saghizadeh, Mehrnoosh

Title(s)Assistant Adjunct Professor, Medicine
SchoolEndocrinology
Phone(310) 248-8696
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Leszczynska A, Kulkarni M, Ljubimov AV, Saghizadeh M. Exosomes from normal and diabetic human corneolimbal keratocytes differentially regulate migration, proliferation and marker expression of limbal epithelial cells. Sci Rep. 2018 10 11; 8(1):15173. PMID: 30310159.
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    2. Saghizadeh M, Kramerov AA, Svendsen CN, Ljubimov AV. Concise Review: Stem Cells for Corneal Wound Healing. Stem Cells. 2017 10; 35(10):2105-2114. PMID: 28748596.
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    3. Kulkarni M, Leszczynska A, Wei G, Winkler MA, Tang J, Funari VA, Deng N, Liu Z, Punj V, Deng SX, Ljubimov AV, Saghizadeh M. Genome-wide analysis suggests a differential microRNA signature associated with normal and diabetic human corneal limbus. Sci Rep. 2017 06 14; 7(1):3448. PMID: 28615632.
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    4. Jones MK, Lu B, Saghizadeh M, Wang S. Gene expression changes in the retina following subretinal injection of human neural progenitor cells into a rodent model for retinal degeneration. Mol Vis. 2016; 22:472-90. PMID: 27217715.
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    5. Kramerov AA, Saghizadeh M, Ljubimov AV. Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells. J Vis Exp. 2016 Apr 07; (110):e54058. PMID: 27077448.
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    6. Kramerov AA, Saghizadeh M, Maguen E, Rabinowitz YS, Ljubimov AV. Persistence of reduced expression of putative stem cell markers and slow wound healing in cultured diabetic limbal epithelial cells. Mol Vis. 2015; 21:1357-67. PMID: 26788028.
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    7. Ljubimov AV, Saghizadeh M. Progress in corneal wound healing. Prog Retin Eye Res. 2015 Nov; 49:17-45. PMID: 26197361.
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    8. Winkler MA, Dib C, Ljubimov AV, Saghizadeh M. Targeting miR-146a to treat delayed wound healing in human diabetic organ-cultured corneas. PLoS One. 2014; 9(12):e114692. PMID: 25490205.
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    9. Saghizadeh M, Dib CM, Brunken WJ, Ljubimov AV. Normalization of wound healing and stem cell marker patterns in organ-cultured human diabetic corneas by gene therapy of limbal cells. Exp Eye Res. 2014 Dec; 129:66-73. PMID: 25446319.
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    10. Sareen D, Saghizadeh M, Ornelas L, Winkler MA, Narwani K, Sahabian A, Funari VA, Tang J, Spurka L, Punj V, Maguen E, Rabinowitz YS, Svendsen CN, Ljubimov AV. Differentiation of human limbal-derived induced pluripotent stem cells into limbal-like epithelium. Stem Cells Transl Med. 2014 Sep; 3(9):1002-12. PMID: 25069777.
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    11. Funari VA, Winkler M, Brown J, Dimitrijevich SD, Ljubimov AV, Saghizadeh M. Differentially expressed wound healing-related microRNAs in the human diabetic cornea. PLoS One. 2013; 8(12):e84425. PMID: 24376808.
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    12. Saghizadeh M, Epifantseva I, Hemmati DM, Ghiam CA, Brunken WJ, Ljubimov AV. Enhanced wound healing, kinase and stem cell marker expression in diabetic organ-cultured human corneas upon MMP-10 and cathepsin F gene silencing. Invest Ophthalmol Vis Sci. 2013 Dec 17; 54(13):8172-80. PMID: 24255036.
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    13. Saghizadeh M, Winkler MA, Kramerov AA, Hemmati DM, Ghiam CA, Dimitrijevich SD, Sareen D, Ornelas L, Ghiasi H, Brunken WJ, Maguen E, Rabinowitz YS, Svendsen CN, Jirsova K, Ljubimov AV. A simple alkaline method for decellularizing human amniotic membrane for cell culture. PLoS One. 2013; 8(11):e79632. PMID: 24236148.
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    14. Saghizadeh M, Soleymani S, Harounian A, Bhakta B, Troyanovsky SM, Brunken WJ, Pellegrini G, Ljubimov AV. Alterations of epithelial stem cell marker patterns in human diabetic corneas and effects of c-met gene therapy. Mol Vis. 2011; 17:2177-90. PMID: 21866211.
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    15. Saghizadeh M, Gribanova Y, Akhmedov NB, Farber DB. ZBED4, a cone and Müller cell protein in human retina, has a different cellular expression in mouse. Mol Vis. 2011; 17:2011-8. PMID: 21850176.
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    16. Farber DB, Theendakara VP, Akhmedov NB, Saghizadeh M. ZBED4, a novel retinal protein expressed in cones and Müller cells. Adv Exp Med Biol. 2010; 664:79-87. PMID: 20238005.
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    17. Saghizadeh M, Kramerov AA, Yu FS, Castro MG, Ljubimov AV. Normalization of wound healing and diabetic markers in organ cultured human diabetic corneas by adenoviral delivery of c-Met gene. Invest Ophthalmol Vis Sci. 2010 Apr; 51(4):1970-80. PMID: 19933191.
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    18. Saghizadeh M, Kramerov AA, Yaghoobzadeh Y, Hu J, Ljubimova JY, Black KL, Castro MG, Ljubimov AV. Adenovirus-driven overexpression of proteinases in organ-cultured normal human corneas leads to diabetic-like changes. Brain Res Bull. 2010 Feb 15; 81(2-3):262-72. PMID: 19828126.
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    19. Saghizadeh M, Akhmedov NB, Yamashita CK, Gribanova Y, Theendakara V, Mendoza E, Nelson SF, Ljubimov AV, Farber DB. ZBED4, a BED-type zinc-finger protein in the cones of the human retina. Invest Ophthalmol Vis Sci. 2009 Aug; 50(8):3580-8. PMID: 19369242.
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    20. Liu J, Saghizadeh M, Tuli SS, Kramerov AA, Lewin AS, Bloom DC, Hauswirth WW, Castro MG, Schultz GS, Ljubimov AV. Different tropism of adenoviruses and adeno-associated viruses to corneal cells: implications for corneal gene therapy. Mol Vis. 2008; 14:2087-96. PMID: 19023450.
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    21. Kramerov AA, Saghizadeh M, Caballero S, Shaw LC, Li Calzi S, Bretner M, Montenarh M, Pinna LA, Grant MB, Ljubimov AV. Inhibition of protein kinase CK2 suppresses angiogenesis and hematopoietic stem cell recruitment to retinal neovascularization sites. Mol Cell Biochem. 2008 Sep; 316(1-2):177-86. PMID: 18612802.
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    22. Maguen E, Rabinowitz YS, Regev L, Saghizadeh M, Sasaki T, Ljubimov AV. Alterations of extracellular matrix components and proteinases in human corneal buttons with INTACS for post-laser in situ keratomileusis keratectasia and keratoconus. Cornea. 2008 Jun; 27(5):565-73. PMID: 18520507.
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    23. Saghizadeh M, Akhmedov NB, Farber DB. Identification and characterization of genes expressed in cone photoreceptors. Adv Exp Med Biol. 2008; 613:235-44. PMID: 18188950.
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    24. Kramerov AA, Saghizadeh M, Pan H, Kabosova A, Montenarh M, Ahmed K, Penn JS, Chan CK, Hinton DR, Grant MB, Ljubimov AV. Expression of protein kinase CK2 in astroglial cells of normal and neovascularized retina. Am J Pathol. 2006 May; 168(5):1722-36. PMID: 16651637.
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    25. Saghizadeh M, Kramerov AA, Tajbakhsh J, Aoki AM, Wang C, Chai NN, Ljubimova JY, Sasaki T, Sosne G, Carlson MR, Nelson SF, Ljubimov AV. Proteinase and growth factor alterations revealed by gene microarray analysis of human diabetic corneas. Invest Ophthalmol Vis Sci. 2005 Oct; 46(10):3604-15. PMID: 16186340.
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    26. Kenney MC, Chwa M, Atilano SR, Tran A, Carballo M, Saghizadeh M, Vasiliou V, Adachi W, Brown DJ. Increased levels of catalase and cathepsin V/L2 but decreased TIMP-1 in keratoconus corneas: evidence that oxidative stress plays a role in this disorder. Invest Ophthalmol Vis Sci. 2005 Mar; 46(3):823-32. PMID: 15728537.
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    27. Saghizadeh M, Brown DJ, Tajbakhsh J, Chen Z, Kenney MC, Farber DB, Nelson SF. Evaluation of techniques using amplified nucleic acid probes for gene expression profiling. Biomol Eng. 2003 Mar; 20(3):97-106. PMID: 12684071.
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    28. Ryder MI, Saghizadeh M, Ding Y, Nguyen N, Soskolne A. Effects of tobacco smoke on the secretion of interleukin-1beta, tumor necrosis factor-alpha, and transforming growth factor-beta from peripheral blood mononuclear cells. Oral Microbiol Immunol. 2002 Dec; 17(6):331-6. PMID: 12485323.
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    29. Ljubimov AV, Saghizadeh M, Pytela R, Sheppard D, Kenney MC. Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas. J Histochem Cytochem. 2001 Nov; 49(11):1341-50. PMID: 11668187.
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    30. Saghizadeh M, Chwa M, Aoki A, Lin B, Pirouzmanesh A, Brown DJ, Ljubimov AV, Kenney MC. Altered expression of growth factors and cytokines in keratoconus, bullous keratopathy and diabetic human corneas. Exp Eye Res. 2001 Aug; 73(2):179-89. PMID: 11446768.
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    31. Saghizadeh M, Brown DJ, Castellon R, Chwa M, Huang GH, Ljubimova JY, Rosenberg S, Spirin KS, Stolitenko RB, Adachi W, Kinoshita S, Murphy G, Windsor LJ, Kenney MC, Ljubimov AV. Overexpression of matrix metalloproteinase-10 and matrix metalloproteinase-3 in human diabetic corneas: a possible mechanism of basement membrane and integrin alterations. Am J Pathol. 2001 Feb; 158(2):723-34. PMID: 11159210.
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    32. Spirin KS, Saghizadeh M, Lewin SL, Zardi L, Kenney MC, Ljubimov AV. Basement membrane and growth factor gene expression in normal and diabetic human retinas. Curr Eye Res. 1999 Jun; 18(6):490-9. PMID: 10435836.
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    33. Ljubimov AV, Saghizadeh M, Spirin KS, Khin HL, Lewin SL, Zardi L, Bourdon MA, Kenney MC. Expression of tenascin-C splice variants in normal and bullous keratopathy human corneas. Invest Ophthalmol Vis Sci. 1998 Jun; 39(7):1135-42. PMID: 9620072.
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    34. Ljubimov AV, Saghizadeh M, Spirin KS, Mecham RP, Sakai LY, Kenney MC. Increased expression of fibrillin-1 in human corneas with bullous keratopathy. Cornea. 1998 May; 17(3):309-14. PMID: 9603388.
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    35. Saghizadeh M, Khin HL, Bourdon MA, Kenney MC, Ljubimov AV. Novel splice variants of human tenascin-C mRNA identified in normal and bullous keratopathy corneas. Cornea. 1998 May; 17(3):326-32. PMID: 9603390.
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    36. Kenney MC, Chwa M, Alba A, Saghizadeh M, Huang ZS, Brown DJ. Localization of TIMP-1, TIMP-2, TIMP-3, gelatinase A and gelatinase B in pathological human corneas. Curr Eye Res. 1998 Mar; 17(3):238-46. PMID: 9543631.
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    37. Saghizadeh M, Ong JM, Garvey WT, Henry RR, Kern PA. The expression of TNF alpha by human muscle. Relationship to insulin resistance. J Clin Invest. 1996 Feb 15; 97(4):1111-6. PMID: 8613535.
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    38. Ong JM, Simsolo RB, Saghizadeh M, Goers JW, Kern PA. Effects of exercise training and feeding on lipoprotein lipase gene expression in adipose tissue, heart, and skeletal muscle of the rat. Metabolism. 1995 Dec; 44(12):1596-605. PMID: 8786730.
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    39. Simsolo RB, Ezzat S, Ong JM, Saghizadeh M, Kern PA. Effects of acromegaly treatment and growth hormone on adipose tissue lipoprotein lipase. J Clin Endocrinol Metab. 1995 Nov; 80(11):3233-8. PMID: 7593431.
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    40. Kern PA, Saghizadeh M, Ong JM, Bosch RJ, Deem R, Simsolo RB. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J Clin Invest. 1995 May; 95(5):2111-9. PMID: 7738178.
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    41. Ranganathan G, Ong JM, Yukht A, Saghizadeh M, Simsolo RB, Pauer A, Kern PA. Tissue-specific expression of human lipoprotein lipase. Effect of the 3'-untranslated region on translation. J Biol Chem. 1995 Mar 31; 270(13):7149-55. PMID: 7706252.
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    42. Ong JM, Simsolo RB, Saghizadeh M, Pauer A, Kern PA. Expression of lipoprotein lipase in rat muscle: regulation by feeding and hypothyroidism. J Lipid Res. 1994 Sep; 35(9):1542-51. PMID: 7806968.
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