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Mehrnoosh Saghizadeh

Title(s)Assistant Adjunct Professor, Medicine
SchoolMedicine
Address760 Westwood Plaza 32-144
Los Angeles CA 90024
Phone(310) 248-8696
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    1. Exosomes from normal and diabetic human corneolimbal keratocytes differentially regulate migration, proliferation and marker expression of limbal epithelial cells. Sci Rep. 2018 10 11; 8(1):15173. Leszczynska A, Kulkarni M, Ljubimov AV, Saghizadeh M. PMID: 30310159.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    2. Concise Review: Stem Cells for Corneal Wound Healing. Stem Cells. 2017 10; 35(10):2105-2114. Saghizadeh M, Kramerov AA, Svendsen CN, Ljubimov AV. PMID: 28748596.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    3. Genome-wide analysis suggests a differential microRNA signature associated with normal and diabetic human corneal limbus. Sci Rep. 2017 06 14; 7(1):3448. Kulkarni M, Leszczynska A, Wei G, Winkler MA, Tang J, Funari VA, Deng N, Liu Z, Punj V, Deng SX, Ljubimov AV, Saghizadeh M. PMID: 28615632.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    4. Gene expression changes in the retina following subretinal injection of human neural progenitor cells into a rodent model for retinal degeneration. Mol Vis. 2016; 22:472-90. Jones MK, Lu B, Saghizadeh M, Wang S. PMID: 27217715.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    5. Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells. J Vis Exp. 2016 Apr 07; (110):e54058. Kramerov AA, Saghizadeh M, Ljubimov AV. PMID: 27077448.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    6. Persistence of reduced expression of putative stem cell markers and slow wound healing in cultured diabetic limbal epithelial cells. Mol Vis. 2015; 21:1357-67. Kramerov AA, Saghizadeh M, Maguen E, Rabinowitz YS, Ljubimov AV. PMID: 26788028.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. Progress in corneal wound healing. Prog Retin Eye Res. 2015 Nov; 49:17-45. Ljubimov AV, Saghizadeh M. PMID: 26197361.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    8. Targeting miR-146a to treat delayed wound healing in human diabetic organ-cultured corneas. PLoS One. 2014; 9(12):e114692. Winkler MA, Dib C, Ljubimov AV, Saghizadeh M. PMID: 25490205.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    9. Normalization of wound healing and stem cell marker patterns in organ-cultured human diabetic corneas by gene therapy of limbal cells. Exp Eye Res. 2014 Dec; 129:66-73. Saghizadeh M, Dib CM, Brunken WJ, Ljubimov AV. PMID: 25446319.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    10. Differentiation of human limbal-derived induced pluripotent stem cells into limbal-like epithelium. Stem Cells Transl Med. 2014 Sep; 3(9):1002-12. Sareen D, Saghizadeh M, Ornelas L, Winkler MA, Narwani K, Sahabian A, Funari VA, Tang J, Spurka L, Punj V, Maguen E, Rabinowitz YS, Svendsen CN, Ljubimov AV. PMID: 25069777.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    11. Differentially expressed wound healing-related microRNAs in the human diabetic cornea. PLoS One. 2013; 8(12):e84425. Funari VA, Winkler M, Brown J, Dimitrijevich SD, Ljubimov AV, Saghizadeh M. PMID: 24376808.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    12. Enhanced wound healing, kinase and stem cell marker expression in diabetic organ-cultured human corneas upon MMP-10 and cathepsin F gene silencing. Invest Ophthalmol Vis Sci. 2013 Dec 17; 54(13):8172-80. Saghizadeh M, Epifantseva I, Hemmati DM, Ghiam CA, Brunken WJ, Ljubimov AV. PMID: 24255036.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    13. A simple alkaline method for decellularizing human amniotic membrane for cell culture. PLoS One. 2013; 8(11):e79632. Saghizadeh M, Winkler MA, Kramerov AA, Hemmati DM, Ghiam CA, Dimitrijevich SD, Sareen D, Ornelas L, Ghiasi H, Brunken WJ, Maguen E, Rabinowitz YS, Svendsen CN, Jirsova K, Ljubimov AV. PMID: 24236148.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    14. Alterations of epithelial stem cell marker patterns in human diabetic corneas and effects of c-met gene therapy. Mol Vis. 2011; 17:2177-90. Saghizadeh M, Soleymani S, Harounian A, Bhakta B, Troyanovsky SM, Brunken WJ, Pellegrini G, Ljubimov AV. PMID: 21866211.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    15. ZBED4, a cone and Müller cell protein in human retina, has a different cellular expression in mouse. Mol Vis. 2011; 17:2011-8. Saghizadeh M, Gribanova Y, Akhmedov NB, Farber DB. PMID: 21850176.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    16. ZBED4, a novel retinal protein expressed in cones and Müller cells. Adv Exp Med Biol. 2010; 664:79-87. Farber DB, Theendakara VP, Akhmedov NB, Saghizadeh M. PMID: 20238005.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    17. Normalization of wound healing and diabetic markers in organ cultured human diabetic corneas by adenoviral delivery of c-Met gene. Invest Ophthalmol Vis Sci. 2010 Apr; 51(4):1970-80. Saghizadeh M, Kramerov AA, Yu FS, Castro MG, Ljubimov AV. PMID: 19933191.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    18. Adenovirus-driven overexpression of proteinases in organ-cultured normal human corneas leads to diabetic-like changes. Brain Res Bull. 2010 Feb 15; 81(2-3):262-72. Saghizadeh M, Kramerov AA, Yaghoobzadeh Y, Hu J, Ljubimova JY, Black KL, Castro MG, Ljubimov AV. PMID: 19828126.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    19. ZBED4, a BED-type zinc-finger protein in the cones of the human retina. Invest Ophthalmol Vis Sci. 2009 Aug; 50(8):3580-8. Saghizadeh M, Akhmedov NB, Yamashita CK, Gribanova Y, Theendakara V, Mendoza E, Nelson SF, Ljubimov AV, Farber DB. PMID: 19369242.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    20. Different tropism of adenoviruses and adeno-associated viruses to corneal cells: implications for corneal gene therapy. Mol Vis. 2008; 14:2087-96. Liu J, Saghizadeh M, Tuli SS, Kramerov AA, Lewin AS, Bloom DC, Hauswirth WW, Castro MG, Schultz GS, Ljubimov AV. PMID: 19023450.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    21. Inhibition of protein kinase CK2 suppresses angiogenesis and hematopoietic stem cell recruitment to retinal neovascularization sites. Mol Cell Biochem. 2008 Sep; 316(1-2):177-86. Kramerov AA, Saghizadeh M, Caballero S, Shaw LC, Li Calzi S, Bretner M, Montenarh M, Pinna LA, Grant MB, Ljubimov AV. PMID: 18612802.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    22. Alterations of extracellular matrix components and proteinases in human corneal buttons with INTACS for post-laser in situ keratomileusis keratectasia and keratoconus. Cornea. 2008 Jun; 27(5):565-73. Maguen E, Rabinowitz YS, Regev L, Saghizadeh M, Sasaki T, Ljubimov AV. PMID: 18520507.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    23. Identification and characterization of genes expressed in cone photoreceptors. Adv Exp Med Biol. 2008; 613:235-44. Saghizadeh M, Akhmedov NB, Farber DB. PMID: 18188950.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    24. Expression of protein kinase CK2 in astroglial cells of normal and neovascularized retina. Am J Pathol. 2006 May; 168(5):1722-36. Kramerov AA, Saghizadeh M, Pan H, Kabosova A, Montenarh M, Ahmed K, Penn JS, Chan CK, Hinton DR, Grant MB, Ljubimov AV. PMID: 16651637.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    25. Proteinase and growth factor alterations revealed by gene microarray analysis of human diabetic corneas. Invest Ophthalmol Vis Sci. 2005 Oct; 46(10):3604-15. Saghizadeh M, Kramerov AA, Tajbakhsh J, Aoki AM, Wang C, Chai NN, Ljubimova JY, Sasaki T, Sosne G, Carlson MR, Nelson SF, Ljubimov AV. PMID: 16186340.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    26. Increased levels of catalase and cathepsin V/L2 but decreased TIMP-1 in keratoconus corneas: evidence that oxidative stress plays a role in this disorder. Invest Ophthalmol Vis Sci. 2005 Mar; 46(3):823-32. Kenney MC, Chwa M, Atilano SR, Tran A, Carballo M, Saghizadeh M, Vasiliou V, Adachi W, Brown DJ. PMID: 15728537.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    27. Evaluation of techniques using amplified nucleic acid probes for gene expression profiling. Biomol Eng. 2003 Mar; 20(3):97-106. Saghizadeh M, Brown DJ, Tajbakhsh J, Chen Z, Kenney MC, Farber DB, Nelson SF. PMID: 12684071.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    28. Effects of tobacco smoke on the secretion of interleukin-1beta, tumor necrosis factor-alpha, and transforming growth factor-beta from peripheral blood mononuclear cells. Oral Microbiol Immunol. 2002 Dec; 17(6):331-6. Ryder MI, Saghizadeh M, Ding Y, Nguyen N, Soskolne A. PMID: 12485323.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    29. Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas. J Histochem Cytochem. 2001 Nov; 49(11):1341-50. Ljubimov AV, Saghizadeh M, Pytela R, Sheppard D, Kenney MC. PMID: 11668187.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    30. Altered expression of growth factors and cytokines in keratoconus, bullous keratopathy and diabetic human corneas. Exp Eye Res. 2001 Aug; 73(2):179-89. Saghizadeh M, Chwa M, Aoki A, Lin B, Pirouzmanesh A, Brown DJ, Ljubimov AV, Kenney MC. PMID: 11446768.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    31. Overexpression of matrix metalloproteinase-10 and matrix metalloproteinase-3 in human diabetic corneas: a possible mechanism of basement membrane and integrin alterations. Am J Pathol. 2001 Feb; 158(2):723-34. Saghizadeh M, Brown DJ, Castellon R, Chwa M, Huang GH, Ljubimova JY, Rosenberg S, Spirin KS, Stolitenko RB, Adachi W, Kinoshita S, Murphy G, Windsor LJ, Kenney MC, Ljubimov AV. PMID: 11159210.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    32. Basement membrane and growth factor gene expression in normal and diabetic human retinas. Curr Eye Res. 1999 Jun; 18(6):490-9. Spirin KS, Saghizadeh M, Lewin SL, Zardi L, Kenney MC, Ljubimov AV. PMID: 10435836.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    33. Expression of tenascin-C splice variants in normal and bullous keratopathy human corneas. Invest Ophthalmol Vis Sci. 1998 Jun; 39(7):1135-42. Ljubimov AV, Saghizadeh M, Spirin KS, Khin HL, Lewin SL, Zardi L, Bourdon MA, Kenney MC. PMID: 9620072.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    34. Increased expression of fibrillin-1 in human corneas with bullous keratopathy. Cornea. 1998 May; 17(3):309-14. Ljubimov AV, Saghizadeh M, Spirin KS, Mecham RP, Sakai LY, Kenney MC. PMID: 9603388.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    35. Novel splice variants of human tenascin-C mRNA identified in normal and bullous keratopathy corneas. Cornea. 1998 May; 17(3):326-32. Saghizadeh M, Khin HL, Bourdon MA, Kenney MC, Ljubimov AV. PMID: 9603390.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    36. Localization of TIMP-1, TIMP-2, TIMP-3, gelatinase A and gelatinase B in pathological human corneas. Curr Eye Res. 1998 Mar; 17(3):238-46. Kenney MC, Chwa M, Alba A, Saghizadeh M, Huang ZS, Brown DJ. PMID: 9543631.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    37. The expression of TNF alpha by human muscle. Relationship to insulin resistance. J Clin Invest. 1996 Feb 15; 97(4):1111-6. Saghizadeh M, Ong JM, Garvey WT, Henry RR, Kern PA. PMID: 8613535.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansAnimalsCells
    38. Effects of exercise training and feeding on lipoprotein lipase gene expression in adipose tissue, heart, and skeletal muscle of the rat. Metabolism. 1995 Dec; 44(12):1596-605. Ong JM, Simsolo RB, Saghizadeh M, Goers JW, Kern PA. PMID: 8786730.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    39. Effects of acromegaly treatment and growth hormone on adipose tissue lipoprotein lipase. J Clin Endocrinol Metab. 1995 Nov; 80(11):3233-8. Simsolo RB, Ezzat S, Ong JM, Saghizadeh M, Kern PA. PMID: 7593431.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    40. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J Clin Invest. 1995 May; 95(5):2111-9. Kern PA, Saghizadeh M, Ong JM, Bosch RJ, Deem R, Simsolo RB. PMID: 7738178.
      View in: PubMed   Mentions: 204     Fields:    Translation:HumansCells
    41. Tissue-specific expression of human lipoprotein lipase. Effect of the 3'-untranslated region on translation. J Biol Chem. 1995 Mar 31; 270(13):7149-55. Ranganathan G, Ong JM, Yukht A, Saghizadeh M, Simsolo RB, Pauer A, Kern PA. PMID: 7706252.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    42. Expression of lipoprotein lipase in rat muscle: regulation by feeding and hypothyroidism. J Lipid Res. 1994 Sep; 35(9):1542-51. Ong JM, Simsolo RB, Saghizadeh M, Pauer A, Kern PA. PMID: 7806968.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
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