Mehrnoosh Saghizadeh

Title(s)Associate Adjunct Professor, Medicine
SchoolMedicine
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    1. MicroRNA and Protein Cargos of Human Limbal Epithelial Cell-Derived Exosomes and Their Regulatory Roles in Limbal Stromal Cells of Diabetic and Non-Diabetic Corneas. Cells. 2023 10 25; 12(21). Verma N, Khare D, Poe AJ, Amador C, Ghiam S, Fealy A, Ebrahimi S, Shadrokh O, Song XY, Santiskulvong C, Mastali M, Parker S, Stotland A, Van Eyk JE, Ljubimov AV, Saghizadeh M. PMID: 37947602; PMCID: PMC10649916.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    2. Reversal of dual epigenetic repression of non-canonical Wnt-5a normalises diabetic corneal epithelial wound healing and stem cells. Diabetologia. 2023 10; 66(10):1943-1958. Shah R, Spektor TM, Weisenberger DJ, Ding H, Patil R, Amador C, Song XY, Chun ST, Inzalaco J, Turjman S, Ghiam S, Jeong-Kim J, Tolstoff S, Yampolsky SV, Sawant OB, Rabinowitz YS, Maguen E, Hamrah P, Svendsen CN, Saghizadeh M, Ljubimova JY, Kramerov AA, Ljubimov AV. PMID: 37460827; PMCID: PMC10474199.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    3. Non-canonical Wnt signaling in the eye. Prog Retin Eye Res. 2023 Jul; 95:101149. Shah R, Amador C, Chun ST, Ghiam S, Saghizadeh M, Kramerov AA, Ljubimov AV. PMID: 36443219; PMCID: PMC10209355.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    4. Regulatory role of miR-146a in corneal epithelial wound healing via its inflammatory targets in human diabetic cornea. Ocul Surf. 2022 07; 25:92-100. Poe AJ, Shah R, Khare D, Kulkarni M, Phan H, Ghiam S, Punj V, Ljubimov AV, Saghizadeh M. PMID: 35690236; PMCID: PMC10200270.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    5. Systemic diseases and the cornea. Exp Eye Res. 2021 03; 204:108455. Shah R, Amador C, Tormanen K, Ghiam S, Saghizadeh M, Arumugaswami V, Kumar A, Kramerov AA, Ljubimov AV. PMID: 33485845; PMCID: PMC7946758.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    6. Novel nanopolymer RNA therapeutics normalize human diabetic corneal wound healing and epithelial stem cells. Nanomedicine. 2021 02; 32:102332. Kramerov AA, Shah R, Ding H, Holler E, Turjman S, Rabinowitz YS, Ghiam S, Maguen E, Svendsen CN, Saghizadeh M, Ljubimova JY, Ljubimov AV. PMID: 33181273; PMCID: PMC8107190.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    7. Integrated Transcriptome and Proteome Analyses Reveal the Regulatory Role of miR-146a in Human Limbal Epithelium via Notch Signaling. Cells. 2020 09 26; 9(10). Poe AJ, Kulkarni M, Leszczynska A, Tang J, Shah R, Jami-Alahmadi Y, Wang J, Kramerov AA, Wohlschlegel J, Punj V, Ljubimov AV, Saghizadeh M. PMID: 32993109; PMCID: PMC7650592.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    8. Exosomes from normal and diabetic human corneolimbal keratocytes differentially regulate migration, proliferation and marker expression of limbal epithelial cells. Sci Rep. 2018 10 11; 8(1):15173. Leszczynska A, Kulkarni M, Ljubimov AV, Saghizadeh M. PMID: 30310159; PMCID: PMC6182003.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    9. Concise Review: Stem Cells for Corneal Wound Healing. Stem Cells. 2017 10; 35(10):2105-2114. Saghizadeh M, Kramerov AA, Svendsen CN, Ljubimov AV. PMID: 28748596; PMCID: PMC5637932.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    10. Genome-wide analysis suggests a differential microRNA signature associated with normal and diabetic human corneal limbus. Sci Rep. 2017 06 14; 7(1):3448. Kulkarni M, Leszczynska A, Wei G, Winkler MA, Tang J, Funari VA, Deng N, Liu Z, Punj V, Deng SX, Ljubimov AV, Saghizadeh M. PMID: 28615632; PMCID: PMC5471258.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    11. Gene expression changes in the retina following subretinal injection of human neural progenitor cells into a rodent model for retinal degeneration. Mol Vis. 2016; 22:472-90. Jones MK, Lu B, Saghizadeh M, Wang S. PMID: 27217715; PMCID: PMC4872275.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    12. Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells. J Vis Exp. 2016 Apr 07; (110):e54058. Kramerov AA, Saghizadeh M, Ljubimov AV. PMID: 27077448; PMCID: PMC4841362.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    13. Persistence of reduced expression of putative stem cell markers and slow wound healing in cultured diabetic limbal epithelial cells. Mol Vis. 2015; 21:1357-67. Kramerov AA, Saghizadeh M, Maguen E, Rabinowitz YS, Ljubimov AV. PMID: 26788028; PMCID: PMC4704770.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    14. Progress in corneal wound healing. Prog Retin Eye Res. 2015 Nov; 49:17-45. Ljubimov AV, Saghizadeh M. PMID: 26197361; PMCID: PMC4651844.
      View in: PubMed   Mentions: 344     Fields:    Translation:HumansAnimalsCells
    15. Targeting miR-146a to treat delayed wound healing in human diabetic organ-cultured corneas. PLoS One. 2014; 9(12):e114692. Winkler MA, Dib C, Ljubimov AV, Saghizadeh M. PMID: 25490205; PMCID: PMC4260878.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    16. Normalization of wound healing and stem cell marker patterns in organ-cultured human diabetic corneas by gene therapy of limbal cells. Exp Eye Res. 2014 Dec; 129:66-73. Saghizadeh M, Dib CM, Brunken WJ, Ljubimov AV. PMID: 25446319; PMCID: PMC4259823.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    17. Differentiation of human limbal-derived induced pluripotent stem cells into limbal-like epithelium. Stem Cells Transl Med. 2014 Sep; 3(9):1002-12. Sareen D, Saghizadeh M, Ornelas L, Winkler MA, Narwani K, Sahabian A, Funari VA, Tang J, Spurka L, Punj V, Maguen E, Rabinowitz YS, Svendsen CN, Ljubimov AV. PMID: 25069777; PMCID: PMC4149305.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    18. Differentially expressed wound healing-related microRNAs in the human diabetic cornea. PLoS One. 2013; 8(12):e84425. Funari VA, Winkler M, Brown J, Dimitrijevich SD, Ljubimov AV, Saghizadeh M. PMID: 24376808; PMCID: PMC3869828.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    19. Enhanced wound healing, kinase and stem cell marker expression in diabetic organ-cultured human corneas upon MMP-10 and cathepsin F gene silencing. Invest Ophthalmol Vis Sci. 2013 Dec 17; 54(13):8172-80. Saghizadeh M, Epifantseva I, Hemmati DM, Ghiam CA, Brunken WJ, Ljubimov AV. PMID: 24255036; PMCID: PMC3867183.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    20. A simple alkaline method for decellularizing human amniotic membrane for cell culture. PLoS One. 2013; 8(11):e79632. Saghizadeh M, Winkler MA, Kramerov AA, Hemmati DM, Ghiam CA, Dimitrijevich SD, Sareen D, Ornelas L, Ghiasi H, Brunken WJ, Maguen E, Rabinowitz YS, Svendsen CN, Jirsova K, Ljubimov AV. PMID: 24236148; PMCID: PMC3827346.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    21. Alterations of epithelial stem cell marker patterns in human diabetic corneas and effects of c-met gene therapy. Mol Vis. 2011; 17:2177-90. Saghizadeh M, Soleymani S, Harounian A, Bhakta B, Troyanovsky SM, Brunken WJ, Pellegrini G, Ljubimov AV. PMID: 21866211; PMCID: PMC3159681.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    22. ZBED4, a cone and Müller cell protein in human retina, has a different cellular expression in mouse. Mol Vis. 2011; 17:2011-8. Saghizadeh M, Gribanova Y, Akhmedov NB, Farber DB. PMID: 21850176; PMCID: PMC3154125.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    23. ZBED4, a novel retinal protein expressed in cones and Müller cells. Adv Exp Med Biol. 2010; 664:79-87. Farber DB, Theendakara VP, Akhmedov NB, Saghizadeh M. PMID: 20238005.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    24. Normalization of wound healing and diabetic markers in organ cultured human diabetic corneas by adenoviral delivery of c-Met gene. Invest Ophthalmol Vis Sci. 2010 Apr; 51(4):1970-80. Saghizadeh M, Kramerov AA, Yu FS, Castro MG, Ljubimov AV. PMID: 19933191; PMCID: PMC2846188.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    25. Adenovirus-driven overexpression of proteinases in organ-cultured normal human corneas leads to diabetic-like changes. Brain Res Bull. 2010 Feb 15; 81(2-3):262-72. Saghizadeh M, Kramerov AA, Yaghoobzadeh Y, Hu J, Ljubimova JY, Black KL, Castro MG, Ljubimov AV. PMID: 19828126; PMCID: PMC2815249.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    26. ZBED4, a BED-type zinc-finger protein in the cones of the human retina. Invest Ophthalmol Vis Sci. 2009 Aug; 50(8):3580-8. Saghizadeh M, Akhmedov NB, Yamashita CK, Gribanova Y, Theendakara V, Mendoza E, Nelson SF, Ljubimov AV, Farber DB. PMID: 19369242; PMCID: PMC2848067.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    27. Different tropism of adenoviruses and adeno-associated viruses to corneal cells: implications for corneal gene therapy. Mol Vis. 2008; 14:2087-96. Liu J, Saghizadeh M, Tuli SS, Kramerov AA, Lewin AS, Bloom DC, Hauswirth WW, Castro MG, Schultz GS, Ljubimov AV. PMID: 19023450; PMCID: PMC2584774.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    28. Inhibition of protein kinase CK2 suppresses angiogenesis and hematopoietic stem cell recruitment to retinal neovascularization sites. Mol Cell Biochem. 2008 Sep; 316(1-2):177-86. Kramerov AA, Saghizadeh M, Caballero S, Shaw LC, Li Calzi S, Bretner M, Montenarh M, Pinna LA, Grant MB, Ljubimov AV. PMID: 18612802; PMCID: PMC2913688.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    29. Alterations of extracellular matrix components and proteinases in human corneal buttons with INTACS for post-laser in situ keratomileusis keratectasia and keratoconus. Cornea. 2008 Jun; 27(5):565-73. Maguen E, Rabinowitz YS, Regev L, Saghizadeh M, Sasaki T, Ljubimov AV. PMID: 18520507; PMCID: PMC2746565.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    30. Identification and characterization of genes expressed in cone photoreceptors. Adv Exp Med Biol. 2008; 613:235-44. Saghizadeh M, Akhmedov NB, Farber DB. PMID: 18188950.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    31. Expression of protein kinase CK2 in astroglial cells of normal and neovascularized retina. Am J Pathol. 2006 May; 168(5):1722-36. Kramerov AA, Saghizadeh M, Pan H, Kabosova A, Montenarh M, Ahmed K, Penn JS, Chan CK, Hinton DR, Grant MB, Ljubimov AV. PMID: 16651637; PMCID: PMC1606582.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    32. Proteinase and growth factor alterations revealed by gene microarray analysis of human diabetic corneas. Invest Ophthalmol Vis Sci. 2005 Oct; 46(10):3604-15. Saghizadeh M, Kramerov AA, Tajbakhsh J, Aoki AM, Wang C, Chai NN, Ljubimova JY, Sasaki T, Sosne G, Carlson MR, Nelson SF, Ljubimov AV. PMID: 16186340; PMCID: PMC1459105.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    33. Increased levels of catalase and cathepsin V/L2 but decreased TIMP-1 in keratoconus corneas: evidence that oxidative stress plays a role in this disorder. Invest Ophthalmol Vis Sci. 2005 Mar; 46(3):823-32. Kenney MC, Chwa M, Atilano SR, Tran A, Carballo M, Saghizadeh M, Vasiliou V, Adachi W, Brown DJ. PMID: 15728537.
      View in: PubMed   Mentions: 85     Fields:    Translation:Humans
    34. Evaluation of techniques using amplified nucleic acid probes for gene expression profiling. Biomol Eng. 2003 Mar; 20(3):97-106. Saghizadeh M, Brown DJ, Tajbakhsh J, Chen Z, Kenney MC, Farber DB, Nelson SF. PMID: 12684071.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    35. Effects of tobacco smoke on the secretion of interleukin-1beta, tumor necrosis factor-alpha, and transforming growth factor-beta from peripheral blood mononuclear cells. Oral Microbiol Immunol. 2002 Dec; 17(6):331-6. Ryder MI, Saghizadeh M, Ding Y, Nguyen N, Soskolne A. PMID: 12485323.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    36. Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas. J Histochem Cytochem. 2001 Nov; 49(11):1341-50. Ljubimov AV, Saghizadeh M, Pytela R, Sheppard D, Kenney MC. PMID: 11668187.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    37. Altered expression of growth factors and cytokines in keratoconus, bullous keratopathy and diabetic human corneas. Exp Eye Res. 2001 Aug; 73(2):179-89. Saghizadeh M, Chwa M, Aoki A, Lin B, Pirouzmanesh A, Brown DJ, Ljubimov AV, Kenney MC. PMID: 11446768.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    38. Overexpression of matrix metalloproteinase-10 and matrix metalloproteinase-3 in human diabetic corneas: a possible mechanism of basement membrane and integrin alterations. Am J Pathol. 2001 Feb; 158(2):723-34. Saghizadeh M, Brown DJ, Castellon R, Chwa M, Huang GH, Ljubimova JY, Rosenberg S, Spirin KS, Stolitenko RB, Adachi W, Kinoshita S, Murphy G, Windsor LJ, Kenney MC, Ljubimov AV. PMID: 11159210; PMCID: PMC1850323.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    39. Basement membrane and growth factor gene expression in normal and diabetic human retinas. Curr Eye Res. 1999 Jun; 18(6):490-9. Spirin KS, Saghizadeh M, Lewin SL, Zardi L, Kenney MC, Ljubimov AV. PMID: 10435836.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    40. Expression of tenascin-C splice variants in normal and bullous keratopathy human corneas. Invest Ophthalmol Vis Sci. 1998 Jun; 39(7):1135-42. Ljubimov AV, Saghizadeh M, Spirin KS, Khin HL, Lewin SL, Zardi L, Bourdon MA, Kenney MC. PMID: 9620072.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    41. Increased expression of fibrillin-1 in human corneas with bullous keratopathy. Cornea. 1998 May; 17(3):309-14. Ljubimov AV, Saghizadeh M, Spirin KS, Mecham RP, Sakai LY, Kenney MC. PMID: 9603388.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    42. Novel splice variants of human tenascin-C mRNA identified in normal and bullous keratopathy corneas. Cornea. 1998 May; 17(3):326-32. Saghizadeh M, Khin HL, Bourdon MA, Kenney MC, Ljubimov AV. PMID: 9603390.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    43. Localization of TIMP-1, TIMP-2, TIMP-3, gelatinase A and gelatinase B in pathological human corneas. Curr Eye Res. 1998 Mar; 17(3):238-46. Kenney MC, Chwa M, Alba A, Saghizadeh M, Huang ZS, Brown DJ. PMID: 9543631.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    44. The expression of TNF alpha by human muscle. Relationship to insulin resistance. J Clin Invest. 1996 Feb 15; 97(4):1111-6. Saghizadeh M, Ong JM, Garvey WT, Henry RR, Kern PA. PMID: 8613535; PMCID: PMC507159.
      View in: PubMed   Mentions: 158     Fields:    Translation:HumansAnimalsCells
    45. Effects of exercise training and feeding on lipoprotein lipase gene expression in adipose tissue, heart, and skeletal muscle of the rat. Metabolism. 1995 Dec; 44(12):1596-605. Ong JM, Simsolo RB, Saghizadeh M, Goers JW, Kern PA. PMID: 8786730.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    46. Effects of acromegaly treatment and growth hormone on adipose tissue lipoprotein lipase. J Clin Endocrinol Metab. 1995 Nov; 80(11):3233-8. Simsolo RB, Ezzat S, Ong JM, Saghizadeh M, Kern PA. PMID: 7593431.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    47. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J Clin Invest. 1995 May; 95(5):2111-9. Kern PA, Saghizadeh M, Ong JM, Bosch RJ, Deem R, Simsolo RB. PMID: 7738178; PMCID: PMC295809.
      View in: PubMed   Mentions: 278     Fields:    Translation:HumansCells
    48. Tissue-specific expression of human lipoprotein lipase. Effect of the 3'-untranslated region on translation. J Biol Chem. 1995 Mar 31; 270(13):7149-55. Ranganathan G, Ong JM, Yukht A, Saghizadeh M, Simsolo RB, Pauer A, Kern PA. PMID: 7706252.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    49. Expression of lipoprotein lipase in rat muscle: regulation by feeding and hypothyroidism. J Lipid Res. 1994 Sep; 35(9):1542-51. Ong JM, Simsolo RB, Saghizadeh M, Pauer A, Kern PA. PMID: 7806968.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
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