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Deng, Sophie X

Title(s)Professor, Ophthalmology
Phone67202
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    Collapse Research 
    Collapse Research Activities and Funding
    Development of small-molecule Wnt mimetics for corneal epithelial cell regeneration
    NIH/NEI R01EY028557Sep 30, 2018 - Aug 31, 2022
    Role: Co-Principal Investigator
    Development of stem cell-based therapies for limbal stem cell deficiency
    NIH/NEI R01EY021797Sep 1, 2012 - Jan 31, 2024
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sun Y, Yung M, Huang L, Tseng C, Deng SX. Limbal Stem Cell Deficiency After Glaucoma Surgery. Cornea. 2020 May; 39(5):566-572. PMID: 31977730.
      View in: PubMed
    2. Le Q, Chauhan T, Yung M, Tseng CH, Deng SX. Outcomes of Limbal Stem Cell Transplant: A Meta-analysis. JAMA Ophthalmol. 2020 Apr 23. PMID: 32324211.
      View in: PubMed
    3. Zhang C, Mei H, Robertson SYT, Lee HJ, Deng SX, Zheng JJ. A Small-Molecule Wnt Mimic Improves Human Limbal Stem Cell Ex Vivo Expansion. iScience. 2020 Apr 18; 23(5):101075. PMID: 32361505.
      View in: PubMed
    4. Liang Q, Le Q, Cordova DW, Tseng CH, Deng SX. Corneal Epithelial Thickness Measured Using AS-OCT as a Diagnostic Parameter for Limbal Stem Cell Deficiency. Am J Ophthalmol. 2020 Apr 10. PMID: 32283095.
      View in: PubMed
    5. Sun Y, Dos Santos A, Balayan A, Deng SX. Evaluation of Cryopreservation Media for the Preservation of Human Corneal Stromal Stem Cells. Tissue Eng Part C Methods. 2020 Jan; 26(1):37-43. PMID: 31686624.
      View in: PubMed
    6. Deng SX, Borderie V, Chan CC, Dana R, Figueiredo FC, Gomes JAP, Pellegrini G, Shimmura S, Kruse FE. Reply. Cornea. 2019 Dec; 38(12):e56-e57. PMID: 31517726.
      View in: PubMed
    7. Pflugfelder SC, Massaro-Giordano M, Perez VL, Hamrah P, Deng SX, Espandar L, Foster CS, Affeldt J, Seedor JA, Afshari NA, Chao W, Allegretti M, Mantelli F, Dana R. Topical Recombinant Human Nerve Growth Factor (Cenegermin) for Neurotrophic Keratopathy: A Multicenter Randomized Vehicle-Controlled Pivotal Trial. Ophthalmology. 2020 01; 127(1):14-26. PMID: 31585826.
      View in: PubMed
    8. González S, Uhm H, Deng SX. Notch Inhibition Prevents Differentiation of Human Limbal Stem/Progenitor Cells in vitro. Sci Rep. 2019 07 17; 9(1):10373. PMID: 31316119.
      View in: PubMed
    9. Le Q, Chauhan T, Deng SX. Diagnostic criteria for limbal stem cell deficiency before surgical intervention-A systematic literature review and analysis. Surv Ophthalmol. 2020 Jan - Feb; 65(1):32-40. PMID: 31276736.
      View in: PubMed
    10. Dos Santos A, Balayan A, Funderburgh ML, Ngo J, Funderburgh JL, Deng SX. Differentiation Capacity of Human Mesenchymal Stem Cells into Keratocyte Lineage. Invest Ophthalmol Vis Sci. 2019 07 01; 60(8):3013-3023. PMID: 31310658.
      View in: PubMed
    11. Lin SR, Prapaipanich P, Yu F, Law SK, Caprioli J, Aldave AJ, Deng SX. Comparison of Endothelial Keratoplasty Techniques in Patients With Prior Glaucoma Surgery: A Case-Matched Study. Am J Ophthalmol. 2019 10; 206:94-101. PMID: 30935848.
      View in: PubMed
    12. Deng SX, Borderie V, Chan CC, Dana R, Figueiredo FC, Gomes JAP, Pellegrini G, Shimmura S, Kruse FE. Global Consensus on Definition, Classification, Diagnosis, and Staging of Limbal Stem Cell Deficiency. Cornea. 2019 Mar; 38(3):364-375. PMID: 30614902.
      View in: PubMed
    13. Le Q, Deng SX. The application of human amniotic membrane in the surgical management of limbal stem cell deficiency. Ocul Surf. 2019 04; 17(2):221-229. PMID: 30633967.
      View in: PubMed
    14. González S, Oh D, Baclagon ER, Zheng JJ, Deng SX. Wnt Signaling Is Required for the Maintenance of Human Limbal Stem/Progenitor Cells In Vitro. Invest Ophthalmol Vis Sci. 2019 01 02; 60(1):107-112. PMID: 30640975.
      View in: PubMed
    15. Aravena C, Bozkurt K, Chuephanich P, Supiyaphun C, Yu F, Deng SX. Classification of Limbal Stem Cell Deficiency Using Clinical and Confocal Grading. Cornea. 2019 Jan; 38(1):1-7. PMID: 30371569.
      View in: PubMed
    16. Le Q, Cordova D, Xu J, Deng SX. In Vivo Evaluation of the Limbus Using Anterior Segment Optical Coherence Tomography. Transl Vis Sci Technol. 2018 Jul; 7(4):12. PMID: 30112250.
      View in: PubMed
    17. Le Q, Samson CM, Deng SX. A Case of Corneal Neovascularization Misdiagnosed as Total Limbal Stem Cell Deficiency. Cornea. 2018 Aug; 37(8):1067-1070. PMID: 29781927.
      View in: PubMed
    18. Sung S, Selvin S, Bajwa N, Chantra S, Nowroozi B, Garritano J, Goell J, Li A, Deng SX, Brown E, Grundfest WS, Taylor ZD. THz imaging system for in vivo human cornea. IEEE Trans Terahertz Sci Technol. 2018 Jan; 8(1):27-37. PMID: 29430335.
      View in: PubMed
    19. Sung S, Dabironezare S, Llombart N, Selvin S, Bajwa N, Chantra S, Nowroozi B, Garritano J, Goell J, Li A, Deng SX, Brown E, Grundfest WS, Taylor ZD. Optical System Design for Noncontact, Normal Incidence, THz Imaging of in vivo Human Cornea. IEEE Trans Terahertz Sci Technol. 2018 Jan; 8(1):1-12. PMID: 29450106.
      View in: PubMed
    20. Le Q, Xu J, Deng SX. The diagnosis of limbal stem cell deficiency. Ocul Surf. 2018 01; 16(1):58-69. PMID: 29113917.
      View in: PubMed
    21. Mei H, González S, Nakatsu MN, Baclagon ER, Chen FV, Deng SX. Human adipose-derived stem cells support the growth of limbal stem/progenitor cells. PLoS One. 2017; 12(10):e0186238. PMID: 29020119.
      View in: PubMed
    22. Deng SX, Lee WB, Hammersmith KM, Kuo AN, Li JY, Shen JF, Weikert MP, Shtein RM. Descemet Membrane Endothelial Keratoplasty: Safety and Outcomes: A Report by the American Academy of Ophthalmology. Ophthalmology. 2018 02; 125(2):295-310. PMID: 28923499.
      View in: PubMed
    23. Kulkarni M, Leszczynska A, Wei G, Winkler MA, Tang J, Funari VA, Deng N, Liu Z, Punj V, Deng SX, Ljubimov AV, Saghizadeh M. Genome-wide analysis suggests a differential microRNA signature associated with normal and diabetic human corneal limbus. Sci Rep. 2017 06 14; 7(1):3448. PMID: 28615632.
      View in: PubMed
    24. González S, Chen L, Deng SX. Comparative Study of Xenobiotic-Free Media for the Cultivation of Human Limbal Epithelial Stem/Progenitor Cells. Tissue Eng Part C Methods. 2017 04; 23(4):219-227. PMID: 28346794.
      View in: PubMed
    25. Aravena C, Yu F, Deng SX. Outcomes of Descemet Membrane Endothelial Keratoplasty in Patients With Previous Glaucoma Surgery. Cornea. 2017 Mar; 36(3):284-289. PMID: 27893525.
      View in: PubMed
    26. Chuephanich P, Supiyaphun C, Aravena C, Bozkurt TK, Yu F, Deng SX. Characterization of the Corneal Subbasal Nerve Plexus in Limbal Stem Cell Deficiency. Cornea. 2017 Mar; 36(3):347-352. PMID: 27941384.
      View in: PubMed
    27. Chan E, Le Q, Codriansky A, Hong J, Xu J, Deng SX. Existence of Normal Limbal Epithelium in Eyes With Clinical Signs of Total Limbal Stem Cell Deficiency. Cornea. 2016 Nov; 35(11):1483-1487. PMID: 27362882.
      View in: PubMed
    28. Le Q, Yang Y, Deng SX, Xu J. Correlation between the existence of the palisades of Vogt and limbal epithelial thickness in limbal stem cell deficiency. Clin Exp Ophthalmol. 2017 Apr; 45(3):224-231. PMID: 27591548.
      View in: PubMed
    29. Wang L, González S, Dai W, Deng S, Lu L. Effect of Hypoxia-regulated Polo-like Kinase 3 (Plk3) on Human Limbal Stem Cell Differentiation. J Biol Chem. 2016 08 05; 291(32):16519-29. PMID: 27281822.
      View in: PubMed
    30. González S, Mei H, Nakatsu MN, Baclagon ER, Deng SX. A 3D culture system enhances the ability of human bone marrow stromal cells to support the growth of limbal stem/progenitor cells. Stem Cell Res. 2016 Mar; 16(2):358-64. PMID: 26896856.
      View in: PubMed
    31. Chen JL, Lin BR, Gee KM, Gee JA, Chung DW, Frausto RF, Deng SX, Aldave AJ. Identification of presumed pathogenic KRT3 and KRT12 gene mutations associated with Meesmann corneal dystrophy. Mol Vis. 2015; 21:1378-86. PMID: 26788030.
      View in: PubMed
    32. Tannan A, Vo RC, Chen JL, Yu F, Deng SX, Aldave AJ. Comparison of ACIOL Retention With IOL Exchange in Patients Undergoing Descemet Stripping Automated Endothelial Keratoplasty. Cornea. 2015 Sep; 34(9):1030-4. PMID: 26147836.
      View in: PubMed
    33. Chan EH, Chen L, Yu F, Deng SX. Epithelial Thinning in Limbal Stem Cell Deficiency. Am J Ophthalmol. 2015 Oct; 160(4):669-77.e4. PMID: 26163009.
      View in: PubMed
    34. Chan EH, Chen L, Rao JY, Yu F, Deng SX. Limbal Basal Cell Density Decreases in Limbal Stem Cell Deficiency. Am J Ophthalmol. 2015 Oct; 160(4):678-84.e4. PMID: 26149968.
      View in: PubMed
    35. Sy ME, Kovoor TA, Tannan A, Choi D, Deng SX, Danesh J, Hamilton DR. Combined astigmatic keratotomy and conductive keratoplasty to correct high corneal astigmatism. J Cataract Refract Surg. 2015 May; 41(5):1050-6. PMID: 25935339.
      View in: PubMed
    36. Taylor ZD, Garritano J, Sung S, Bajwa N, Bennett DB, Nowroozi B, Tewari P, Sayre JW, Hubschman JP, Deng SX, Brown ER, Grundfest WS. THz and mm-Wave Sensing of Corneal Tissue Water Content: In Vivo Sensing and Imaging Results. IEEE Trans Terahertz Sci Technol. 2015 Mar; 5(2):184-196. PMID: 26161292.
      View in: PubMed
    37. Taylor ZD, Garritano J, Sung S, Bajwa N, Bennett DB, Nowroozi B, Tewari P, Sayre J, Hubschman JP, Deng S, Brown ER, Grundfest WS. THz and mm-Wave Sensing of Corneal Tissue Water Content: Electromagnetic Modeling and Analysis. IEEE Trans Terahertz Sci Technol. 2015 Mar; 5(2):170-183. PMID: 26322247.
      View in: PubMed
    38. Sung S, Garritano J, Bajwa N, Deng S, Hubschman JP, Grundfest WS, Taylor ZD. Preliminary results of non-contact THz imaging of cornea. Proc SPIE Int Soc Opt Eng. 2015 Feb 07; 9362. PMID: 26321784.
      View in: PubMed
    39. Deng SX, Sanchez PJ, Chen L. Clinical outcomes of Descemet membrane endothelial keratoplasty using eye bank-prepared tissues. Am J Ophthalmol. 2015 Mar; 159(3):590-6. PMID: 25526945.
      View in: PubMed
    40. Hong J, Le Q, Deng SX, Cao W, Xu J. Pseudomonas aeruginosa keratitis misdiagnosed as fungal keratitis by in vivo confocal microscopy: a case report. BMC Res Notes. 2014 Dec 13; 7:907. PMID: 25495791.
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    41. Hong J, Qian T, Yang Y, Jiang C, Liu Z, Sun X, Deng SX, Xu J. Corneal epithelial thickness map in long-term soft contact lenses wearers. Optom Vis Sci. 2014 Dec; 91(12):1455-61. PMID: 25303838.
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    42. Cui X, Hong J, Wang F, Deng SX, Yang Y, Zhu X, Wu D, Zhao Y, Xu J. Assessment of corneal epithelial thickness in dry eye patients. Optom Vis Sci. 2014 Dec; 91(12):1446-54. PMID: 25279779.
      View in: PubMed
    43. Schlötzer-Schrehardt U, Bachmann BO, Tourtas T, Torricelli AA, Singh A, González S, Mei H, Deng SX, Wilson SE, Kruse FE. Ultrastructure of the posterior corneal stroma. Ophthalmology. 2015 Apr; 122(4):693-9. PMID: 25458195.
      View in: PubMed
    44. Nakatsu MN, González S, Mei H, Deng SX. Human limbal mesenchymal cells support the growth of human corneal epithelial stem/progenitor cells. Invest Ophthalmol Vis Sci. 2014 Oct 02; 55(10):6953-9. PMID: 25277234.
      View in: PubMed
    45. Hong J, Yu Z, Cui X, Qian T, Le Q, Wei A, Liu Z, Sun X, Deng SX, Xu J. Meibomian Gland Alteration in Patients with Primary Chronic Dacryocystitis: An In vivo Confocal Microscopy Study. Curr Eye Res. 2015; 40(8):772-9. PMID: 25266812.
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    46. Gangalum RK, Jing Z, Bhat AM, Lee J, Nagaoka Y, Deng SX, Jiang M, Bhat SP. Expression of the HSF4 DNA binding domain-EGFP hybrid gene recreates early childhood lamellar cataract in transgenic mice. Invest Ophthalmol Vis Sci. 2014 Aug 28; 55(11):7227-40. PMID: 25168898.
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    47. Hong J, Yang Y, Wei A, Deng SX, Kong X, Chen J, Girard MJ, Mari JM, Xu J, Sun X. Schlemm's canal expands after trabeculectomy in patients with primary angle-closure glaucoma. Invest Ophthalmol Vis Sci. 2014 Aug 12; 55(9):5637-42. PMID: 25118266.
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    48. Vo RC, Stafeeva K, Aldave AJ, Stulting RD, Moore Q, Pflugfelder SC, Chungfat NC, Holsclaw DS, Margolis TP, Deng SX. Complications related to a cosmetic eye-whitening procedure. Am J Ophthalmol. 2014 Nov; 158(5):967-73. PMID: 25072832.
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    49. Yang Y, Hong J, Deng SX, Xu J. Age-related changes in human corneal epithelial thickness measured with anterior segment optical coherence tomography. Invest Ophthalmol Vis Sci. 2014 Jul 22; 55(8):5032-8. PMID: 25052994.
      View in: PubMed
    50. Mei H, Nakatsu MN, Baclagon ER, Deng SX. Frizzled 7 maintains the undifferentiated state of human limbal stem/progenitor cells. Stem Cells. 2014 Apr; 32(4):938-45. PMID: 24170316.
      View in: PubMed
    51. Aldave AJ, Chen JL, Zaman AS, Deng SX, Yu F. Outcomes after DSEK in 101 eyes with previous trabeculectomy and tube shunt implantation. Cornea. 2014 Mar; 33(3):223-9. PMID: 24322807.
      View in: PubMed
    52. Mei H, González S, Nakatsu MN, Baclagon ER, Lopes VS, Williams DS, Deng SX. A three-dimensional culture method to expand limbal stem/progenitor cells. Tissue Eng Part C Methods. 2014 May; 20(5):393-400. PMID: 24047104.
      View in: PubMed
    53. González S, Deng SX. Presence of native limbal stromal cells increases the expansion efficiency of limbal stem/progenitor cells in culture. Exp Eye Res. 2013 Nov; 116:169-76. PMID: 24016868.
      View in: PubMed
    54. Nakatsu MN, Vartanyan L, Vu DM, Ng MY, Li X, Deng SX. Preferential biological processes in the human limbus by differential gene profiling. PLoS One. 2013; 8(4):e61833. PMID: 23630617.
      View in: PubMed
    55. Hong J, Xu J, Wei A, Deng SX, Cui X, Yu X, Sun X. A new tonometer--the Corvis ST tonometer: clinical comparison with noncontact and Goldmann applanation tonometers. Invest Ophthalmol Vis Sci. 2013 Jan 23; 54(1):659-65. PMID: 23307970.
      View in: PubMed
    56. Nakatsu MN, Deng SX. Enrichment of human corneal epithelial stem/progenitor cells by magnetic bead sorting using SSEA4 as a negative marker. Methods Mol Biol. 2013; 1014:71-7. PMID: 23690006.
      View in: PubMed
    57. Sejpal K, Bakhtiari P, Deng SX. Presentation, diagnosis and management of limbal stem cell deficiency. Middle East Afr J Ophthalmol. 2013 Jan-Mar; 20(1):5-10. PMID: 23580847.
      View in: PubMed
    58. Mei H, Gonzalez S, Deng SX. Extracellular Matrix is an Important Component of Limbal Stem Cell Niche. J Funct Biomater. 2012 Dec 10; 3(4):879-94. PMID: 24955751.
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    59. Kurbanyan K, Sejpal KD, Aldave AJ, Deng SX. In vivo confocal microscopic findings in Lisch corneal dystrophy. Cornea. 2012 Apr; 31(4):437-41. PMID: 22222997.
      View in: PubMed
    60. Wang L, Deng SX, Lu L. Role of CTCF in EGF-induced migration of immortalized human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2012 Feb; 53(2):946-51. PMID: 22247490.
      View in: PubMed
    61. Deng SX, Sejpal KD, Tang Q, Aldave AJ, Lee OL, Yu F. Characterization of limbal stem cell deficiency by in vivo laser scanning confocal microscopy: a microstructural approach. Arch Ophthalmol. 2012 Apr; 130(4):440-5. PMID: 22159172.
      View in: PubMed
    62. Zarei-Ghanavati S, Ramirez-Miranda A, Deng SX. Limbal lacuna: a novel limbal structure detected by in vivo laser scanning confocal microscopy. Ophthalmic Surg Lasers Imaging. 2011 Dec 08; 42 Online:e129-31. PMID: 22150603.
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    63. Wiaux C, Baghdasaryan E, Lee OL, Bourges JL, Deng SX, Yu F, Aldave AJ. Outcomes after Descemet stripping endothelial keratoplasty in glaucoma patients with previous trabeculectomy and tube shunt implantation. Cornea. 2011 Dec; 30(12):1304-11. PMID: 21963858.
      View in: PubMed
    64. Truong TT, Huynh K, Nakatsu MN, Deng SX. SSEA4 is a potential negative marker for the enrichment of human corneal epithelial stem/progenitor cells. Invest Ophthalmol Vis Sci. 2011 Aug 11; 52(9):6315-20. PMID: 21685344.
      View in: PubMed
    65. Nakatsu MN, Ding Z, Ng MY, Truong TT, Yu F, Deng SX. Wnt/ß-catenin signaling regulates proliferation of human cornea epithelial stem/progenitor cells. Invest Ophthalmol Vis Sci. 2011 Jul 01; 52(7):4734-41. PMID: 21357396.
      View in: PubMed
    66. Ramirez-Miranda A, Nakatsu MN, Zarei-Ghanavati S, Nguyen CV, Deng SX. Keratin 13 is a more specific marker of conjunctival epithelium than keratin 19. Mol Vis. 2011; 17:1652-61. PMID: 21738394.
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    67. Zarei-Ghanavati S, Baghdasaryan E, Ramirez-Miranda A, Nguyen M, Yu F, Lee GJ, Deng SX. Elevated intraocular pressure is a common complication during active microbial keratitis. Am J Ophthalmol. 2011 Oct; 152(4):575-581.e1. PMID: 21683333.
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    68. Hong J, Zheng T, Xu J, Deng SX, Chen L, Sun X, Le Q, Li Y. Assessment of limbus and central cornea in patients with keratolimbal allograft transplantation using in vivo laser scanning confocal microscopy: an observational study. Graefes Arch Clin Exp Ophthalmol. 2011 May; 249(5):701-8. PMID: 21267594.
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    69. Tsui I, Uslan DZ, Hubschman JP, Deng SX. Nocardia farcinica Infection of a Baerveldt implant and endophthalmitis in a patient with a Boston type I keratoprosthesis. J Glaucoma. 2010 Jun-Jul; 19(5):339-40. PMID: 19855295.
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    70. Deng SX, Kamal KM, Hollander DA. The use of voriconazole in the management of post-penetrating keratoplasty Paecilomyces keratitis. J Ocul Pharmacol Ther. 2009 Apr; 25(2):175-7. PMID: 19284327.
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    71. Ding Z, Dong J, Liu J, Deng SX. Preferential gene expression in the limbus of the vervet monkey. Mol Vis. 2008; 14:2031-41. PMID: 18989386.
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    72. Asbell PA, Colby KA, Deng S, McDonnell P, Meisler DM, Raizman MB, Sheppard JD, Sahm DF. Ocular TRUST: nationwide antimicrobial susceptibility patterns in ocular isolates. Am J Ophthalmol. 2008 Jun; 145(6):951-958. PMID: 18374299.
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