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Suraj P Bhat

Title(s)Professor-in-Residence, Ophthalmology
SchoolMedicine
Phone59543, 59544
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    Collapse Research 
    Collapse Research Activities and Funding
    Childhood Cataractogenesis: Heterogeneity of Gene Expression
    NIH/NEI R01EY024929Jan 1, 2015 - Dec 31, 2019
    Role: Principal Investigator
    Cloning the Gene for Blepharophimosis Syndrome
    NIH/NEI R01EY011645Mar 1, 1998 - Jul 31, 2006
    Role: Principal Investigator
    Gene Expression in Normal and Cataractous Lens
    NIH/NEI R01EY006044Jan 1, 1985 - May 31, 2011
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Bhat SP, Gangalum RK, Kim D, Mangul S, Kashyap RK, Zhou X, Elashoff D. Transcriptional profiling of single fiber cells in a transgenic paradigm of an inherited childhood cataract reveals absence of molecular heterogeneity. J Biol Chem. 2019 09 13; 294(37):13530-13544. PMID: 31243103.
      View in: PubMed
    2. Bhat SP. The developing ocular lens: A practical paradigm for probing chromatin landscape and gene expression. Dev Biol. 2019 Sep 01; 453(1):105-106. PMID: 31129080.
      View in: PubMed
    3. Gangalum RK, Kim D, Kashyap RK, Mangul S, Zhou X, Elashoff D, Bhat SP. Spatial Analysis of Single Fiber Cells of the Developing Ocular Lens Reveals Regulated Heterogeneity of Gene Expression. iScience. 2018 Dec 21; 10:66-79. PMID: 30508719.
      View in: PubMed
    4. Piatigorsky J, Bassnett S, McAvoy J, Bhat SP. David C. Beebe, 1944-2015, in memoriam. Exp Eye Res. 2017 03; 156:3-4. PMID: 28174024.
      View in: PubMed
    5. Gangalum RK, Bhat AM, Kohan SA, Bhat SP. Inhibition of the Expression of the Small Heat Shock Protein aB-Crystallin Inhibits Exosome Secretion in Human Retinal Pigment Epithelial Cells in Culture. J Biol Chem. 2016 Jun 17; 291(25):12930-42. PMID: 27129211.
      View in: PubMed
    6. Gangalum RK, Jing Z, Bhat AM, Lee J, Nagaoka Y, Deng SX, Jiang M, Bhat SP. Expression of the HSF4 DNA binding domain-EGFP hybrid gene recreates early childhood lamellar cataract in transgenic mice. Invest Ophthalmol Vis Sci. 2014 Aug 28; 55(11):7227-40. PMID: 25168898.
      View in: PubMed
    7. Jing Z, Gangalum RK, Bhat AM, Nagaoka Y, Jiang M, Bhat SP. HSF4 mutation p.Arg116His found in age-related cataracts and in normal populations produces childhood lamellar cataract in transgenic mice. Hum Mutat. 2014 Sep; 35(9):1068-71. PMID: 24975927.
      View in: PubMed
    8. Jing Z, Gangalum RK, Mock DC, Bhat SP. A gene-specific non-enhancer sequence is critical for expression from the promoter of the small heat shock protein gene aB-crystallin. Hum Genomics. 2014 Mar 03; 8:5. PMID: 24589182.
      View in: PubMed
    9. Jing Z, Gangalum RK, Lee JZ, Mock D, Bhat SP. Cell-type-dependent access of HSF1 and HSF4 to aB-crystallin promoter during heat shock. Cell Stress Chaperones. 2013 May; 18(3):377-87. PMID: 23264262.
      View in: PubMed
    10. Gangalum RK, Horwitz J, Kohan SA, Bhat SP. aA-crystallin and aB-crystallin reside in separate subcellular compartments in the developing ocular lens. J Biol Chem. 2012 Dec 07; 287(50):42407-16. PMID: 23071119.
      View in: PubMed
    11. Rao NA, Saraswathy S, Pararajasegaram G, Bhat SP. Small heat shock protein aA-crystallin prevents photoreceptor degeneration in experimental autoimmune uveitis. PLoS One. 2012; 7(3):e33582. PMID: 22479415.
      View in: PubMed
    12. Yellore VS, Rayner SA, Nguyen CK, Gangalum RK, Jing Z, Bhat SP, Aldave AJ. Analysis of the role of ZEB1 in the pathogenesis of posterior polymorphous corneal dystrophy. Invest Ophthalmol Vis Sci. 2012 Jan 25; 53(1):273-8. PMID: 22199242.
      View in: PubMed
    13. Gangalum RK, Jing Z, Nagaoka Y, Jiang M, Bhat SP, Bhat SP. Purification of BAC DNA for high-efficiency transgenesis. Biotechniques. 2011 Nov; 51(5):335-6, 338. PMID: 22054546.
      View in: PubMed
    14. Bhat SP, Gangalum RK. Secretion of aB-Crystallin via exosomes: New clues to the function of human retinal pigment epithelium. Commun Integr Biol. 2011 Nov 01; 4(6):739-41. PMID: 22446542.
      View in: PubMed
    15. Gangalum RK, Atanasov IC, Zhou ZH, Bhat SP. AlphaB-crystallin is found in detergent-resistant membrane microdomains and is secreted via exosomes from human retinal pigment epithelial cells. J Biol Chem. 2011 Feb 04; 286(5):3261-9. PMID: 21097504.
      View in: PubMed
    16. Gangalum RK, Bhat SP. AlphaB-crystallin: a Golgi-associated membrane protein in the developing ocular lens. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3283-90. PMID: 19218604.
      View in: PubMed
    17. Rao NA, Saraswathy S, Wu GS, Katselis GS, Wawrousek EF, Bhat S. Elevated retina-specific expression of the small heat shock protein, alphaA-crystallin, is associated with photoreceptor protection in experimental uveitis. Invest Ophthalmol Vis Sci. 2008 Mar; 49(3):1161-71. PMID: 18326745.
      View in: PubMed
    18. Bhat SP. Transparency and non-refractive functions of crystallins--a proposal. Exp Eye Res. 2004 Dec; 79(6):809-16. PMID: 15642317.
      View in: PubMed
    19. Gangalum RK, Schibler MJ, Bhat SP. Small heat shock protein alphaB-crystallin is part of cell cycle-dependent Golgi reorganization. J Biol Chem. 2004 Oct 15; 279(42):43374-7. PMID: 15339919.
      View in: PubMed
    20. Somasundaram T, Bhat SP. Developmentally dictated expression of heat shock factors: exclusive expression of HSF4 in the postnatal lens and its specific interaction with alphaB-crystallin heat shock promoter. J Biol Chem. 2004 Oct 22; 279(43):44497-503. PMID: 15308659.
      View in: PubMed
    21. Bhat SP, Rayner SA, Chau SC, Ariyasu RG. Pax-6 expression in posthatch chick retina during and recovery from form-deprivation myopia. Dev Neurosci. 2004; 26(5-6):328-35. PMID: 15855761.
      View in: PubMed
    22. Bhat SP. Crystallins, genes and cataract. Prog Drug Res. 2003; 60:205-62. PMID: 12790344.
      View in: PubMed
    23. Bhat SP. The ocular lens epithelium. Biosci Rep. 2001 Aug; 21(4):537-63. PMID: 11900326.
      View in: PubMed
    24. Bhat SP, Rayner SA, Huang CM, Ariyasu RG. Quantitative estimation of RNA transcripts suggests persistence of Pax-6 expression in the postembryonic chick retina. Dev Neurosci. 1999; 21(2):140-6. PMID: 10449986.
      View in: PubMed