Suraj P Bhat

Title(s)Professor-in-Residence, Ophthalmology
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    Suraj P. Bhat, Ph.D., holds the Oppenheimer Brothers Chair.

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    Childhood Cataractogenesis: Heterogeneity of Gene Expression
    NIH R01EY024929Jan 1, 2015 - Dec 31, 2019
    Role: Principal Investigator
    Cloning the Gene for Blepharophimosis Syndrome
    NIH R01EY011645Mar 1, 1998 - Jul 31, 2006
    Role: Principal Investigator
    Gene Expression in Normal and Cataractous Lens
    NIH R01EY006044Jan 1, 1985 - May 31, 2011
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Transcriptional profiling of single fiber cells in a transgenic paradigm of an inherited childhood cataract reveals absence of molecular heterogeneity. J Biol Chem. 2019 09 13; 294(37):13530-13544. Bhat SP, Gangalum RK, Kim D, Mangul S, Kashyap RK, Zhou X, Elashoff D. PMID: 31243103; PMCID: PMC6746439.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    2. The developing ocular lens: A practical paradigm for probing chromatin landscape and gene expression. Dev Biol. 2019 09 01; 453(1):105-106. Bhat SP. PMID: 31129080.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    3. Spatial Analysis of Single Fiber Cells of the Developing Ocular Lens Reveals Regulated Heterogeneity of Gene Expression. iScience. 2018 Dec 21; 10:66-79. Gangalum RK, Kim D, Kashyap RK, Mangul S, Zhou X, Elashoff D, Bhat SP. PMID: 30508719; PMCID: PMC6277220.
      View in: PubMed   Mentions: 8  
    4. David C. Beebe, 1944-2015, in memoriam. Exp Eye Res. 2017 03; 156:3-4. Piatigorsky J, Bassnett S, McAvoy J, Bhat SP. PMID: 28174024.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Inhibition of the Expression of the Small Heat Shock Protein αB-Crystallin Inhibits Exosome Secretion in Human Retinal Pigment Epithelial Cells in Culture. J Biol Chem. 2016 Jun 17; 291(25):12930-42. Gangalum RK, Bhat AM, Kohan SA, Bhat SP. PMID: 27129211; PMCID: PMC4933212.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    6. Expression of the HSF4 DNA binding domain-EGFP hybrid gene recreates early childhood lamellar cataract in transgenic mice. Invest Ophthalmol Vis Sci. 2014 Aug 28; 55(11):7227-40. Gangalum RK, Jing Z, Bhat AM, Lee J, Nagaoka Y, Deng SX, Jiang M, Bhat SP. PMID: 25168898; PMCID: PMC4231995.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    7. HSF4 mutation p.Arg116His found in age-related cataracts and in normal populations produces childhood lamellar cataract in transgenic mice. Hum Mutat. 2014 Sep; 35(9):1068-71. Jing Z, Gangalum RK, Bhat AM, Nagaoka Y, Jiang M, Bhat SP. PMID: 24975927; PMCID: PMC4134754.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    8. A gene-specific non-enhancer sequence is critical for expression from the promoter of the small heat shock protein gene αB-crystallin. Hum Genomics. 2014 Mar 03; 8:5. Jing Z, Gangalum RK, Mock DC, Bhat SP. PMID: 24589182; PMCID: PMC3975602.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    9. Cell-type-dependent access of HSF1 and HSF4 to αB-crystallin promoter during heat shock. Cell Stress Chaperones. 2013 May; 18(3):377-87. Jing Z, Gangalum RK, Lee JZ, Mock D, Bhat SP. PMID: 23264262; PMCID: PMC3631099.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    10. αA-crystallin and αB-crystallin reside in separate subcellular compartments in the developing ocular lens. J Biol Chem. 2012 Dec 07; 287(50):42407-16. Gangalum RK, Horwitz J, Kohan SA, Bhat SP. PMID: 23071119; PMCID: PMC3516784.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    11. India's science: elitism prevails. Science. 2012 Apr 20; 336(6079):295-6. Bhat SP. PMID: 22517840.
      View in: PubMed   Mentions:    Fields:    
    12. Small heat shock protein αA-crystallin prevents photoreceptor degeneration in experimental autoimmune uveitis. PLoS One. 2012; 7(3):e33582. Rao NA, Saraswathy S, Pararajasegaram G, Bhat SP. PMID: 22479415; PMCID: PMC3316578.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    13. Analysis of the role of ZEB1 in the pathogenesis of posterior polymorphous corneal dystrophy. Invest Ophthalmol Vis Sci. 2012 Jan 25; 53(1):273-8. Yellore VS, Rayner SA, Nguyen CK, Gangalum RK, Jing Z, Bhat SP, Aldave AJ. PMID: 22199242; PMCID: PMC3292363.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    14. Secretion of αB-Crystallin via exosomes: New clues to the function of human retinal pigment epithelium. Commun Integr Biol. 2011 Nov 01; 4(6):739-41. Bhat SP, Gangalum RK. PMID: 22446542; PMCID: PMC3306346.
      View in: PubMed   Mentions: 12  
    15. Purification of BAC DNA for high-efficiency transgenesis. Biotechniques. 2011 Nov; 51(5):335-6, 338. Gangalum RK, Jing Z, Nagaoka Y, Jiang M, Bhat SP, Bhat SP. PMID: 22054546.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    16. AlphaB-crystallin is found in detergent-resistant membrane microdomains and is secreted via exosomes from human retinal pigment epithelial cells. J Biol Chem. 2011 Feb 04; 286(5):3261-9. Gangalum RK, Atanasov IC, Zhou ZH, Bhat SP. PMID: 21097504; PMCID: PMC3030331.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    17. AlphaB-crystallin: a Golgi-associated membrane protein in the developing ocular lens. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3283-90. Gangalum RK, Bhat SP. PMID: 19218604; PMCID: PMC2871768.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    18. Elevated retina-specific expression of the small heat shock protein, alphaA-crystallin, is associated with photoreceptor protection in experimental uveitis. Invest Ophthalmol Vis Sci. 2008 Mar; 49(3):1161-71. Rao NA, Saraswathy S, Wu GS, Katselis GS, Wawrousek EF, Bhat S. PMID: 18326745.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    19. Transparency and non-refractive functions of crystallins--a proposal. Exp Eye Res. 2004 Dec; 79(6):809-16. Bhat SP. PMID: 15642317.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    20. Small heat shock protein alphaB-crystallin is part of cell cycle-dependent Golgi reorganization. J Biol Chem. 2004 Oct 15; 279(42):43374-7. Gangalum RK, Schibler MJ, Bhat SP. PMID: 15339919.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    21. Developmentally dictated expression of heat shock factors: exclusive expression of HSF4 in the postnatal lens and its specific interaction with alphaB-crystallin heat shock promoter. J Biol Chem. 2004 Oct 22; 279(43):44497-503. Somasundaram T, Bhat SP. PMID: 15308659.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    22. Pax-6 expression in posthatch chick retina during and recovery from form-deprivation myopia. Dev Neurosci. 2004; 26(5-6):328-35. Bhat SP, Rayner SA, Chau SC, Ariyasu RG. PMID: 15855761.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    23. Crystallins, genes and cataract. Prog Drug Res. 2003; 60:205-62. Bhat SP. PMID: 12790344.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    24. The ocular lens epithelium. Biosci Rep. 2001 Aug; 21(4):537-63. Bhat SP. PMID: 11900326.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    25. Quantitative estimation of RNA transcripts suggests persistence of Pax-6 expression in the postembryonic chick retina. Dev Neurosci. 1999; 21(2):140-6. Bhat SP, Rayner SA, Huang CM, Ariyasu RG. PMID: 10449986.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
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