X. William Yang

Title(s)Professor-in-Residence, Psychiatry and Biobehavioral Sciences
SchoolMedicine
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    Collapse Biography 
    Collapse education and training
    Yale University, New Have, CTB.S.05/1991Molecular Biophysics & Biochemistry
    Yale University , New Have, CTM.S.05/1991Molecular Biophysics & Biochemistry
    Rockefeller University , New York, NYPh.D.06/1998Neuroscience & Molecular Genetics
    Weill Medical College of Cornell University , New York, NYM.D.06/2000Medicine
    New York-Presbyterian Hospital/Cornell Medical Center, New York, NY06/2001Internal Medicine
    Rockefeller University, New York, NY06/2002Neuroscience & Molecular Genetics
    Collapse awards and honors
    Yale University1991Summa cum laude
    Center for Excellence in Education 2013Center for Excellence in Education Outstanding Alumni in STEM and Business
    The McKnight Endowment Fund for Neuroscience2009  - 2012McKnight Neuroscience of Brain Disorders Award
    UCLA2011  - 2016The Carol Moss Spivak Scholar in Neuroscience
    Hereditary Disease Foundation 2014Leslie Gehry Brenner Prize for Innovation in Science
    UCLA2019The Terry Semel Chair in Alzheimer’s Disease Research and Treatment
    American Society for Clinical Investigation 2017Elected Member, American Society for Clinical Investigation

    Collapse Overview 
    Collapse overview
    Dr. X. William Yang is Professor in Psychiatry and holds the Terry Semel Chair in Alzheimer's Disease Research and Treatment. He co-invented a powerful mouse genetic technology to engineer Bacterial Artificial Chromosomes (BACs) and generate BAC transgenic mice. His laboratory at UCLA has made significant contributions to developing a series of BAC transgenic mouse models for human neurodegenerative disorders, including Huntington’s, Parkinson’s, and Alzheimer’s diseases. Using such models, they have elucidated novel disease mechanisms as well as therapeutic targets. The Yang lab has also applied novel genetic and systems biology approaches to study brain gene expression and decipher molecular networks for HD and AD. Furthermore, they investigate the role of basal ganglia circuitry in the generation of normal and pathological behaviors. The Yang lab invented a new mouse genetic tool (MORF mice) for the sparse and bright labelling of thousands of neurons and glial cells to illuminate their exquisite morphology. Dr. Yang is a recipient of the NIH’s BRAIN Initiative awards, the McKnight Foundation’s Brain Disorder Award, and the HDF’s 2014 Leslie Gehry Brenner Prize for Innovation in Science. He is an elected member of the American Society for Clinical Investigation and serves as the Co-Vice Chair of the Scientific Advisory Board for the Hereditary Disease Foundation. Dr. Yang is also an associate editor for Molecular Neurodegeneration and Journal of Huntington's disease.

    Collapse Research 
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    Next-generation MORF Mice for Scalable Brainwide Morphological Mapping and Genetic Perturbation of Single Neurons
    NIH RF1MH128888Sep 10, 2021 - Aug 31, 2024
    Role: Principal Investigator
    Novel mouse genetic models to study modifiers of Huntington?s disease
    NIH R01NS113612Jul 1, 2019 - Jun 30, 2024
    Role: Principal Investigator
    Dendritome mapping of genetically-defined and sparsely-labeled cortical and striatal projection neurons
    NIH U01MH117079Sep 1, 2018 - May 31, 2023
    Role: Principal Investigator
    BAC Transgenic Mouse Models of TREM2 to Study Neuroprotective Mechanisms in AD
    NIH/NIA R01AG056114Apr 1, 2017 - Mar 31, 2022
    Role: Principal Investigator
    BAC Transgenic Mouse Models of TREM2 to Study Neuroprotective Mechanisms in AD
    NIH RF1AG056114Apr 1, 2017 - Mar 31, 2022
    Role: Principal Investigator
    Novel Genetic Strategy for Sparse Labeling and Manipulation of Mammalian Neurons
    NIH U01MH106008Sep 26, 2014 - May 31, 2018
    Role: Principal Investigator
    Complement-Microglia Interaction in Synaptic Loss and Neurodegeneration in HD
    NIH R01NS084298Jul 1, 2014 - Jun 30, 2020
    Role: Principal Investigator
    CHDI-UCLA Collaborative Research on Huntington’s Disease Systems Biology
    CHDI FOUNDATION, INC. CHDIJul 1, 2013 - Jun 30, 2025
    Role: Principle Investigator
    Validating NT17 Dependent Mechanisms in Huntington's Disease Suppression
    NIH R01NS074312Sep 30, 2011 - Jun 30, 2016
    Role: Principal Investigator
    Basal Ganglia Circuitry and Molecules in Pathogenesis of Motor Stereotypy
    NIH R01HD065298Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Conditional Models: non-cell-autonomous Toxicities in HD
    NIH R01NS049501Sep 1, 2004 - May 31, 2016
    Role: Principal Investigator
    Genetic Suppressors of Huntington's Disease in Mice
    NIH R21NS047391Jun 1, 2004 - May 31, 2006
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Featured Content 
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Regulation of Mutant Huntingtin Mitochondrial Toxicity by Phosphomimetic Mutations within Its N-Terminal Region. J Neurosci. 2025 Feb 19; 45(8). Yablonska S, Strohlein CE, Baranov SV, Yeh SM, Patel A, Singh T, Jauhari A, Kim J, Khattar NK, Li F, Wang X, Chang YF, Lee CYD, Yang XW, Carlisle DL, Friedlander RM. PMID: 39779371; PMCID: PMC11841767.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Distinct mismatch-repair complex genes set neuronal CAG-repeat expansion rate to drive selective pathogenesis in HD mice. Cell. 2025 Mar 20; 188(6):1524-1544.e22. Wang N, Zhang S, Langfelder P, Ramanathan L, Gao F, Plascencia M, Vaca R, Gu X, Deng L, Dionisio LE, Vu H, Maciejewski E, Ernst J, Prasad BC, Vogt TF, Horvath S, Aaronson JS, Rosinski J, Yang XW. PMID: 39938516; PMCID: PMC11972609.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Dendritome Mapping Unveils Spatial Organization of Striatal D1/D2-Neuron Morphology. bioRxiv. 2024 Oct 24. Park CS, Yan M, Zhu M, Akram MA, Foster NN, Bennecke A, Choi C, Marrett K, Moradi K, Zhang JY, Magat G, Nanda S, Vaca R, Wijaya K, Zablan JR, Lee S, Song C, Lara MJ, Louie M, Cong J, Kim Y, Ascoli GA, Langfelder P, Tward D, Dong HW, Yang XW. PMID: 39484488; PMCID: PMC11526962.
      View in: PubMed   Mentions:
    4. Gossamer: Scaling Image Processing and Reconstruction to Whole Brains. bioRxiv. 2024 Jul 04. Marrett K, Moradi K, Park CS, Yan M, Choi C, Zhu M, Akram M, Nanda S, Xue Q, Mun HS, Gutierrez AE, Rudd M, Zingg B, Magat G, Wijaya K, Dong H, Yang XW, Cong J. PMID: 38645196; PMCID: PMC11030332.
      View in: PubMed   Mentions:
    5. Integrated platform for multiscale molecular imaging and phenotyping of the human brain. Science. 2024 06 14; 384(6701):eadh9979. Park J, Wang J, Guan W, Gjesteby LA, Pollack D, Kamentsky L, Evans NB, Stirman J, Gu X, Zhao C, Marx S, Kim ME, Choi SW, Snyder M, Chavez D, Su-Arcaro C, Tian Y, Park CS, Zhang Q, Yun DH, Moukheiber M, Feng G, Yang XW, Keene CD, Hof PR, Ghosh SS, Frosch MP, Brattain LJ, Chung K. PMID: 38870291; PMCID: PMC11830150.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    6. Epigenetic predictors of species maximum life span and other life-history traits in mammals. Sci Adv. 2024 Jun 07; 10(23):eadm7273. Li CZ, Haghani A, Yan Q, Lu AT, Zhang J, Fei Z, Ernst J, Yang XW, Gladyshev VN, Robeck TR, Chavez AS, Cook JA, Dunnum JL, Raj K, Seluanov A, Gorbunova V, Horvath S. PMID: 38848365; PMCID: PMC11160467.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    7. m1A in CAG repeat RNA binds to TDP-43 and induces neurodegeneration. Nature. 2023 Nov; 623(7987):580-587. Sun Y, Dai H, Dai X, Yin J, Cui Y, Liu X, Gonzalez G, Yuan J, Tang F, Wang N, Perlegos AE, Bonini NM, Yang XW, Gu W, Wang Y. PMID: 37938769; PMCID: PMC10651481.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    8. Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington's disease. Nat Med. 2023 Nov; 29(11):2866-2884. Wilton DK, Mastro K, Heller MD, Gergits FW, Willing CR, Fahey JB, Frouin A, Daggett A, Gu X, Kim YA, Faull RLM, Jayadev S, Yednock T, Yang XW, Stevens B. PMID: 37814059; PMCID: PMC10667107.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    9. Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington's disease. Mol Ther. 2023 Nov 01; 31(11):3355-3356. O'Reilly D, Belgrad J, Ferguson C, Summers A, Sapp E, McHugh C, Mathews E, Boudi A, Buchwald J, Ly S, Moreno D, Furgal R, Luu E, Kennedy Z, Hariharan V, Monopoli K, Yang XW, Carroll J, DiFiglia M, Aronin N, Khvorova A. PMID: 37751745; PMCID: PMC10638064.
      View in: PubMed   Mentions: 3     Fields:    
    10. DNA methylation networks underlying mammalian traits. Science. 2023 08 11; 381(6658):eabq5693. Haghani A, Li CZ, Robeck TR, Zhang J, Lu AT, Ablaeva J, Acosta-Rodríguez VA, Adams DM, Alagaili AN, Almunia J, Aloysius A, Amor NMS, Ardehali R, Arneson A, Baker CS, Banks G, Belov K, Bennett NC, Black P, Blumstein DT, Bors EK, Breeze CE, Brooke RT, Brown JL, Carter G, Caulton A, Cavin JM, Chakrabarti L, Chatzistamou I, Chavez AS, Chen H, Cheng K, Chiavellini P, Choi OW, Clarke S, Cook JA, Cooper LN, Cossette ML, Day J, DeYoung J, Dirocco S, Dold C, Dunnum JL, Ehmke EE, Emmons CK, Emmrich S, Erbay E, Erlacher-Reid C, Faulkes CG, Fei Z, Ferguson SH, Finno CJ, Flower JE, Gaillard JM, Garde E, Gerber L, Gladyshev VN, Goya RG, Grant MJ, Green CB, Hanson MB, Hart DW, Haulena M, Herrick K, Hogan AN, Hogg CJ, Hore TA, Huang T, Izpisua Belmonte JC, Jasinska AJ, Jones G, Jourdain E, Kashpur O, Katcher H, Katsumata E, Kaza V, Kiaris H, Kobor MS, Kordowitzki P, Koski WR, Krützen M, Kwon SB, Larison B, Lee SG, Lehmann M, Lemaître JF, Levine AJ, Li X, Li C, Lim AR, Lin DTS, Lindemann DM, Liphardt SW, Little TJ, Macoretta N, Maddox D, Matkin CO, Mattison JA, McClure M, Mergl J, Meudt JJ, Montano GA, Mozhui K, Munshi-South J, Murphy WJ, Naderi A, Nagy M, Narayan P, Nathanielsz PW, Nguyen NB, Niehrs C, Nyamsuren B, O'Brien JK, Ginn PO, Odom DT, Ophir AG, Osborn S, Ostrander EA, Parsons KM, Paul KC, Pedersen AB, Pellegrini M, Peters KJ, Petersen JL, Pietersen DW, Pinho GM, Plassais J, Poganik JR, Prado NA, Reddy P, Rey B, Ritz BR, Robbins J, Rodriguez M, Russell J, Rydkina E, Sailer LL, Salmon AB, Sanghavi A, Schachtschneider KM, Schmitt D, Schmitt T, Schomacher L, Schook LB, Sears KE, Seifert AW, Shafer ABA, Shindyapina AV, Simmons M, Singh K, Sinha I, Slone J, Snell RG, Soltanmohammadi E, Spangler ML, Spriggs M, Staggs L, Stedman N, Steinman KJ, Stewart DT, Sugrue VJ, Szladovits B, Takahashi JS, Takasugi M, Teeling EC, Thompson MJ, Van Bonn B, Vernes SC, Villar D, Vinters HV, Vu H, Wallingford MC, Wang N, Wilkinson GS, Williams RW, Yan Q, Yao M, Young BG, Zhang B, Zhang Z, Zhao Y, Zhao P, Zhou W, Zoller JA, Ernst J, Seluanov A, Gorbunova V, Yang XW, Raj K, Horvath S. PMID: 37561875; PMCID: PMC11180965.
      View in: PubMed   Mentions: 45     Fields:    
    11. BAC Transgenic Expression of Human TREM2-R47H Remodels Amyloid Plaques but Unable to Reprogram Plaque-associated Microglial Reactivity in 5xFAD Mice. bioRxiv. 2023 Aug 05. Lee CYD, De La Rocha AJ, Inouye K, Langfelder P, Daggett A, Gu X, Jiang LL, Pamonag Z, Vaca RG, Richman J, Kawaguchi R, Gao F, Xu H, Yang XW. PMID: 37577582; PMCID: PMC10418161.
      View in: PubMed   Mentions:
    12. Unconventional Activation of IRE1 Enhances TH17 Responses and Promotes Neutrophilic Airway Inflammation. bioRxiv. 2023 Jul 08. Wu D, Zhang X, Zimmerly KM, Wang R, Livingston A, Iwawaki T, Kumar A, Wu X, Mandell MA, Liu M, Yang XO. PMID: 37461622; PMCID: PMC10349957.
      View in: PubMed   Mentions:
    13. Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington's disease. Mol Ther. 2023 06 07; 31(6):1661-1674. O'Reilly D, Belgrad J, Ferguson C, Summers A, Sapp E, McHugh C, Mathews E, Boudi A, Buchwald J, Ly S, Moreno D, Furgal R, Luu E, Kennedy Z, Hariharan V, Monopoli K, Yang XW, Carroll J, DiFiglia M, Aronin N, Khvorova A. PMID: 37177784; PMCID: PMC10277892.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    14. Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures. Neuron. 2022 10 19; 110(20):3318-3338.e9. Wang N, Langfelder P, Stricos M, Ramanathan L, Richman JB, Vaca R, Plascencia M, Gu X, Zhang S, Tamai TK, Zhang L, Gao F, Ouk K, Lu X, Ivanov LV, Vogt TF, Lu QR, Morton AJ, Colwell CS, Aaronson JS, Rosinski J, Horvath S, Yang XW. PMID: 36265442; PMCID: PMC9665885.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    15. Group dynamics goes awry: PolyQ-expanded huntingtin gains unwanted partners. Cell Syst. 2022 04 20; 13(4):268-270. Dionisio LE, Yang XW. PMID: 35447076.
      View in: PubMed   Mentions: 1     Fields:    
    16. Uninterrupted CAG repeat drives striatum-selective transcriptionopathy and nuclear pathogenesis in human Huntingtin BAC mice. Neuron. 2022 04 06; 110(7):1173-1192.e7. Gu X, Richman J, Langfelder P, Wang N, Zhang S, Bañez-Coronel M, Wang HB, Yang L, Ramanathan L, Deng L, Park CS, Choi CR, Cantle JP, Gao F, Gray M, Coppola G, Bates GP, Ranum LPW, Horvath S, Colwell CS, Yang XW. PMID: 35114102; PMCID: PMC9462388.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    17. The mouse cortico-basal ganglia-thalamic network. Nature. 2021 10; 598(7879):188-194. Foster NN, Barry J, Korobkova L, Garcia L, Gao L, Becerra M, Sherafat Y, Peng B, Li X, Choi JH, Gou L, Zingg B, Azam S, Lo D, Khanjani N, Zhang B, Stanis J, Bowman I, Cotter K, Cao C, Yamashita S, Tugangui A, Li A, Jiang T, Jia X, Feng Z, Aquino S, Mun HS, Zhu M, Santarelli A, Benavidez NL, Song M, Dan G, Fayzullina M, Ustrell S, Boesen T, Johnson DL, Xu H, Bienkowski MS, Yang XW, Gong H, Levine MS, Wickersham I, Luo Q, Hahn JD, Lim BK, Zhang LI, Cepeda C, Hintiryan H, Dong HW. PMID: 34616074; PMCID: PMC8494639.
      View in: PubMed   Mentions: 102     Fields:    Translation:AnimalsCells
    18. Morphological diversity of single neurons in molecularly defined cell types. Nature. 2021 10; 598(7879):174-181. Peng H, Xie P, Liu L, Kuang X, Wang Y, Qu L, Gong H, Jiang S, Li A, Ruan Z, Ding L, Yao Z, Chen C, Chen M, Daigle TL, Dalley R, Ding Z, Duan Y, Feiner A, He P, Hill C, Hirokawa KE, Hong G, Huang L, Kebede S, Kuo HC, Larsen R, Lesnar P, Li L, Li Q, Li X, Li Y, Li Y, Liu A, Lu D, Mok S, Ng L, Nguyen TN, Ouyang Q, Pan J, Shen E, Song Y, Sunkin SM, Tasic B, Veldman MB, Wakeman W, Wan W, Wang P, Wang Q, Wang T, Wang Y, Xiong F, Xiong W, Xu W, Ye M, Yin L, Yu Y, Yuan J, Yuan J, Yun Z, Zeng S, Zhang S, Zhao S, Zhao Z, Zhou Z, Huang ZJ, Esposito L, Hawrylycz MJ, Sorensen SA, Yang XW, Zheng Y, Gu Z, Xie W, Koch C, Luo Q, Harris JA, Wang Y, Zeng H. PMID: 34616072; PMCID: PMC8494643.
      View in: PubMed   Mentions: 137     Fields:    Translation:HumansCells
    19. Cellular anatomy of the mouse primary motor cortex. Nature. 2021 10; 598(7879):159-166. Muñoz-Castañeda R, Zingg B, Matho KS, Chen X, Wang Q, Foster NN, Li A, Narasimhan A, Hirokawa KE, Huo B, Bannerjee S, Korobkova L, Park CS, Park YG, Bienkowski MS, Chon U, Wheeler DW, Li X, Wang Y, Naeemi M, Xie P, Liu L, Kelly K, An X, Attili SM, Bowman I, Bludova A, Cetin A, Ding L, Drewes R, D'Orazi F, Elowsky C, Fischer S, Galbavy W, Gao L, Gillis J, Groblewski PA, Gou L, Hahn JD, Hatfield JT, Hintiryan H, Huang JJ, Kondo H, Kuang X, Lesnar P, Li X, Li Y, Lin M, Lo D, Mizrachi J, Mok S, Nicovich PR, Palaniswamy R, Palmer J, Qi X, Shen E, Sun YC, Tao HW, Wakemen W, Wang Y, Yao S, Yuan J, Zhan H, Zhu M, Ng L, Zhang LI, Lim BK, Hawrylycz M, Gong H, Gee JC, Kim Y, Chung K, Yang XW, Peng H, Luo Q, Mitra PP, Zador AM, Zeng H, Ascoli GA, Josh Huang Z, Osten P, Harris JA, Dong HW. PMID: 34616071; PMCID: PMC8494646.
      View in: PubMed   Mentions: 96     Fields:    Translation:AnimalsCells
    20. CPEB alteration and aberrant transcriptome-polyadenylation lead to a treatable SLC19A3 deficiency in Huntington's disease. Sci Transl Med. 2021 Sep 29; 13(613):eabe7104. Picó S, Parras A, Santos-Galindo M, Pose-Utrilla J, Castro M, Fraga E, Hernández IH, Elorza A, Anta H, Wang N, Martí-Sánchez L, Belloc E, Garcia-Esparcia P, Garrido JJ, Ferrer I, Macías-García D, Mir P, Artuch R, Pérez B, Hernández F, Navarro P, López-Sendón JL, Iglesias T, Yang XW, Méndez R, Lucas JJ. PMID: 34586830.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    21. RORα is critical for mTORC1 activity in T cell-mediated colitis. Cell Rep. 2021 09 14; 36(11):109682. Chi X, Jin W, Bai X, Zhao X, Shao J, Li J, Sun Q, Su B, Wang X, Yang XO, Dong C. PMID: 34525365.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    22. Castration delays epigenetic aging and feminizes DNA methylation at androgen-regulated loci. Elife. 2021 07 06; 10. Sugrue VJ, Zoller JA, Narayan P, Lu AT, Ortega-Recalde OJ, Grant MJ, Bawden CS, Rudiger SR, Haghani A, Bond DM, Hore RR, Garratt M, Sears KE, Wang N, Yang XW, Snell RG, Hore TA, Horvath S. PMID: 34227937; PMCID: PMC8260231.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    23. Adiponectin restrains ILC2 activation by AMPK-mediated feedback inhibition of IL-33 signaling. J Exp Med. 2021 02 01; 218(2). Wang L, Luo Y, Luo L, Wu D, Ding X, Zheng H, Wu H, Liu B, Yang X, Silva F, Wang C, Zhang X, Zheng X, Chen J, Brigman J, Mandell M, Zhou Z, Liu F, Yang XO, Liu M. PMID: 33104171; PMCID: PMC7590510.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    24. PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington's disease. Proc Natl Acad Sci U S A. 2021 01 26; 118(4). Morozko EL, Smith-Geater C, Monteys AM, Pradhan S, Lim RG, Langfelder P, Kachemov M, Kulkarni JA, Zaifman J, Hill A, Stocksdale JT, Cullis PR, Wu J, Ochaba J, Miramontes R, Chakraborty A, Hazra TK, Lau A, St-Cyr S, Orellana I, Kopan L, Wang KQ, Yeung S, Leavitt BR, Reidling JC, Yang XW, Steffan JS, Davidson BL, Sarkar PS, Thompson LM. PMID: 33468657; PMCID: PMC7848703.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    25. Disease-related Huntingtin seeding activities in cerebrospinal fluids of Huntington's disease patients. Sci Rep. 2020 11 20; 10(1):20295. Lee CYD, Wang N, Shen K, Stricos M, Langfelder P, Cheon KH, Cortés EP, Vinters HV, Vonsattel JP, Wexler NS, Damoiseaux R, Frydman J, Yang XW. PMID: 33219289; PMCID: PMC7679413.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    26. Author Correction: Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment. Nat Immunol. 2020 Nov; 21(11):1467. Yang XO, Angkasekwinai P, Zhu J, Peng J, Liu Z, Nurieva R, Liu X, Chung Y, Chang SH, Sun B, Dong C. PMID: 32884131.
      View in: PubMed   Mentions:    Fields:    
    27. Brainwide Genetic Sparse Cell Labeling to Illuminate the Morphology of Neurons and Glia with Cre-Dependent MORF Mice. Neuron. 2020 10 14; 108(1):111-127.e6. Veldman MB, Park CS, Eyermann CM, Zhang JY, Zuniga-Sanchez E, Hirano AA, Daigle TL, Foster NN, Zhu M, Langfelder P, Lopez IA, Brecha NC, Zipursky SL, Zeng H, Dong HW, Yang XW. PMID: 32795398; PMCID: PMC7572760.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    28. Huntington's Disease: Genome-wide Neuroprotection Screening Goes Viral. Neuron. 2020 04 08; 106(1):4-6. Lee CYD, Yang XW. PMID: 32272066.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    29. Treg expression of CIS suppresses allergic airway inflammation through antagonizing an autonomous TH2 program. Mucosal Immunol. 2020 03; 13(2):293-302. Zheng H, Wu X, Wu D, Jiang RL, Castillo EF, Chock CJ, Zhou Q, Liu M, Dong C, Yang XO. PMID: 31780776; PMCID: PMC7044046.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    30. Clinical and Genetic Profiles in Chinese Patients with Huntington's Disease: A Ten-year Multicenter Study in China. Aging Dis. 2019 Oct; 10(5):1003-1011. Li HL, Li XY, Dong Y, Zhang YB, Cheng HR, Gan SR, Liu ZJ, Ni W, Burgunder JM, Yang XW, Wu ZY. PMID: 31595198; PMCID: PMC6764736.
      View in: PubMed   Mentions: 13     Fields:    
    31. Dosage sensitivity intolerance of VIPR2 microduplication is disease causative to manifest schizophrenia-like phenotypes in a novel BAC transgenic mouse model. Mol Psychiatry. 2019 12; 24(12):1884-1901. Tian X, Richard A, El-Saadi MW, Bhandari A, Latimer B, Van Savage I, Holmes K, Klein RL, Dwyer D, Goeders NE, Yang XW, Lu XH. PMID: 31444475.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    32. Interleukin-17 receptor D constitutes an alternative receptor for interleukin-17A important in psoriasis-like skin inflammation. Sci Immunol. 2019 06 07; 4(36). Su Y, Huang J, Zhao X, Lu H, Wang W, Yang XO, Shi Y, Wang X, Lai Y, Dong C. PMID: 31175175.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    33. Interleukin-17 receptor D constitutes an alternative receptor for interleukin-17A important in psoriasis-like skin inflammation. Sci Immunol. 2019 06 07; 4(36). Su Y, Huang J, Zhao X, Lu H, Wang W, Yang XO, Shi Y, Wang X, Lai Y, Dong C. PMID: 31175175.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    34. Precise segmentation of densely interweaving neuron clusters using G-Cut. Nat Commun. 2019 04 04; 10(1):1549. Li R, Zhu M, Li J, Bienkowski MS, Foster NN, Xu H, Ard T, Bowman I, Zhou C, Veldman MB, Yang XW, Hintiryan H, Zhang J, Dong HW. PMID: 30948706; PMCID: PMC6449501.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    35. Huntington Disease's Glial Progenitor Cells Hit the Pause Button in the Mouse Brain. Cell Stem Cell. 2019 01 03; 24(1):3-4. Wang N, Yang XW. PMID: 30609397.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    36. Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models. Neuron. 2018 03 07; 97(5):1032-1048.e5. Lee CYD, Daggett A, Gu X, Jiang LL, Langfelder P, Li X, Wang N, Zhao Y, Park CS, Cooper Y, Ferando I, Mody I, Coppola G, Xu H, Yang XW. PMID: 29518357; PMCID: PMC5927822.
      View in: PubMed   Mentions: 167     Fields:    Translation:HumansAnimalsCells
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    102. Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice. J Neurosci. 2008 Jun 11; 28(24):6182-95. Gray M, Shirasaki DI, Cepeda C, André VM, Wilburn B, Lu XH, Tao J, Yamazaki I, Li SH, Sun YE, Li XJ, Levine MS, Yang XW. PMID: 18550760; PMCID: PMC2630800.
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    103. Regulation of inflammatory responses by IL-17F. J Exp Med. 2008 May 12; 205(5):1063-75. Yang XO, Chang SH, Park H, Nurieva R, Shah B, Acero L, Wang YH, Schluns KS, Broaddus RR, Zhu Z, Dong C. PMID: 18411338; PMCID: PMC2373839.
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    104. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity. 2008 Jan; 28(1):29-39. Yang XO, Pappu BP, Nurieva R, Akimzhanov A, Kang HS, Chung Y, Ma L, Shah B, Panopoulos AD, Schluns KS, Watowich SS, Tian Q, Jetten AM, Dong C. PMID: 18164222; PMCID: PMC2587175.
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    105. Genetic control of instrumental conditioning by striatopallidal neuron-specific S1P receptor Gpr6. Nat Neurosci. 2007 Nov; 10(11):1395-7. Lobo MK, Cui Y, Ostlund SB, Balleine BW, Yang XW. PMID: 17934457.
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    106. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature. 2007 Jul 26; 448(7152):480-3. Nurieva R, Yang XO, Martinez G, Zhang Y, Panopoulos AD, Ma L, Schluns K, Tian Q, Watowich SS, Jetten AM, Dong C. PMID: 17581589.
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    107. Pathological cell-cell interactions are necessary for striatal pathogenesis in a conditional mouse model of Huntington's disease. Mol Neurodegener. 2007 Apr 30; 2:8. Gu X, André VM, Cepeda C, Li SH, Li XJ, Levine MS, Yang XW. PMID: 17470275; PMCID: PMC1885431.
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    108. Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation. J Biol Chem. 2007 Mar 02; 282(9):5969-72. Akimzhanov AM, Yang XO, Dong C. PMID: 17218320.
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    109. Modified bacterial artificial chromosomes for zebrafish transgenesis. Methods. 2006 Jul; 39(3):183-8. Yang Z, Jiang H, Chaichanasakul T, Chachainasakul T, Gong S, Yang XW, Heintz N, Lin S. PMID: 16828309.
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    110. FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains. Nat Neurosci. 2006 Mar; 9(3):443-52. Lobo MK, Karsten SL, Gray M, Geschwind DH, Yang XW. PMID: 16491081.
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    111. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol. 2005 Nov; 6(11):1133-41. Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, Wang Y, Hood L, Zhu Z, Tian Q, Dong C. PMID: 16200068; PMCID: PMC1618871.
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    112. Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice. Neuron. 2005 May 05; 46(3):433-44. Gu X, Li C, Wei W, Lo V, Gong S, Li SH, Iwasato T, Itohara S, Li XJ, Mody I, Heintz N, Yang XW. PMID: 15882643.
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    113. Modification of bacterial artificial chromosomes (BACs) and preparation of intact BAC DNA for generation of transgenic mice. Curr Protoc Neurosci. 2005 May; Chapter 5:Unit 5.21. Gong S, Yang XW. PMID: 18428623.
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    114. An overview on the generation of BAC transgenic mice for neuroscience research. Curr Protoc Neurosci. 2005 May; Chapter 5:Unit 5.20. Yang XW, Gong S. PMID: 18428622.
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    115. Regulation of T-cell receptor D beta 1 promoter by KLF5 through reiterated GC-rich motifs. Blood. 2003 Jun 01; 101(11):4492-9. Yang XO, Doty RT, Hicks JS, Willerford DM. PMID: 12576331.
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    116. Regulation of T-cell receptor D beta 1 promoter by KLF5 through reiterated GC-rich motifs. Blood. 2003 Jun 01; 101(11):4492-9. Yang XO, Doty RT, Hicks JS, Willerford DM. PMID: 12576331.
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    117. Highly efficient modification of bacterial artificial chromosomes (BACs) using novel shuttle vectors containing the R6Kgamma origin of replication. Genome Res. 2002 Dec; 12(12):1992-8. Gong S, Yang XW, Li C, Heintz N. PMID: 12466304; PMCID: PMC187570.
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    118. JAK2, complemented by a second signal from c-kit or flt-3, triggers extensive self-renewal of primary multipotential hemopoietic cells. EMBO J. 2002 May 01; 21(9):2159-67. Zhao S, Zoller K, Masuko M, Rojnuckarin P, Yang XO, Parganas E, Kaushansky K, Ihle JN, Papayannopoulou T, Willerford DM, Clackson T, Blau CA. PMID: 11980713; PMCID: PMC125991.
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    119. A rapid method for targeted modification and screening of recombinant bacterial artificial chromosome. J Immunol Methods. 2001 Nov 01; 257(1-2):99-105. Misulovin Z, Yang XW, Yu W, Heintz N, Meffre E. PMID: 11687243.
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    120. BAC-mediated gene-dosage analysis reveals a role for Zipro1 (Ru49/Zfp38) in progenitor cell proliferation in cerebellum and skin. Nat Genet. 1999 Aug; 22(4):327-35. Yang XW, Wynder C, Doughty ML, Heintz N. PMID: 10431235.
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    121. Homologous recombination based modification in Escherichia coli and germline transmission in transgenic mice of a bacterial artificial chromosome. Nat Biotechnol. 1997 Sep; 15(9):859-65. Yang XW, Model P, Heintz N. PMID: 9306400.
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    122. Distinct molecular signals for nuclear import of the nucleolar snRNA, U3. Genes Dev. 1992 Jun; 6(6):1120-30. Baserga SJ, Gilmore-Hebert M, Yang XW. PMID: 1592260.
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    123. Three pseudogenes for human U13 snRNA belong to class III. Gene. 1991 Nov 15; 107(2):347-8. Baserga SJ, Yang XD, Steitz JA. PMID: 1748306.
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    124. An intact Box C sequence in the U3 snRNA is required for binding of fibrillarin, the protein common to the major family of nucleolar snRNPs. EMBO J. 1991 Sep; 10(9):2645-51. Baserga SJ, Yang XD, Steitz JA. PMID: 1714385; PMCID: PMC452965.
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