Kate Wassum

Title(s)	Professor, Psychology
School	College of Letters and Science
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Research

Research Activities and Funding

Nucleus accumbens circuits for regulating cue-motivated behavior
NIH R01MH126285Apr 2, 2021 - Jan 31, 2026
Role: Co-Principal Investigator

Epigenetic Regulation Of Striatal Circuit Function For Action And Habit Learning
NIH R01DA046679Apr 1, 2019 - Jan 31, 2024
Role: Principal Investigator

Amygdala-cortical circuitry in reward encoding, expectation, and decision making
NIH R01DA035443May 1, 2013 - Dec 31, 2023
Role: Principal Investigator

Opioid and Glutamate Modulation of Reward Value During Goal-Directed Behavior
NIH F31DA023774Dec 1, 2007 - Nov 30, 2011
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Cognitive representations of intracranial self-stimulation of midbrain dopamine neurons depend on stimulation frequency. Nat Neurosci. 2024 May 13. Millard SJ, Hoang IB, Sherwood S, Taira M, Reyes V, Greer Z, O'Connor SL, Wassum KM, James MH, Barker DJ, Sharpe MJ. PMID: 38741021.

View in: PubMed Mentions: Fields:
Neu Neurology
Translation:Animals Cells
Maximizing Electrochemical Information: A Perspective on Background-Inclusive Fast Voltammetry. Anal Chem. 2024 Apr 10. Movassaghi CS, Alcañiz Fillol M, Kishida KT, McCarty G, Sombers LA, Wassum KM, Andrews AM. PMID: 38597398.

View in: PubMed Mentions: Fields:
Che Chemistry Techniques
Dopamine projections to the basolateral amygdala drive the encoding of identity-specific reward memories. Nat Neurosci. 2024 Apr; 27(4):728-736. Sias AC, Jafar Y, Goodpaster CM, Ramírez-Armenta K, Wrenn TM, Griffin NK, Patel K, Lamparelli AC, Sharpe MJ, Wassum KM. PMID: 38396258; PMCID: PMC11110430.

View in: PubMed Mentions: 1 Fields:
Neu Neurology
Translation:Animals
Anterior cingulate and medial prefrontal cortex alcohol cue reactivity varies as a function of drink preference in alcohol use disorder. Drug Alcohol Depend. 2024 Mar 01; 256:111123. Kirsch DE, Ray LA, Wassum KM, Grodin EN. PMID: 38367535.

View in: PubMed Mentions: Fields:
Sub Substance-Related Disorders
Translation:Humans
A dual-pathway architecture enables chronic stress to promote habit formation. bioRxiv. 2023 Oct 03. Giovanniello JR, Paredes N, Wiener A, Ramírez-Armenta K, Oragwam C, Uwadia HO, Lim K, Nnamdi G, Wang A, Sehgal M, Reis FM, Sias AC, Silva AJ, Adhikari A, Malvaez M, Wassum KM. PMID: 37873076; PMCID: PMC10592885.

View in: PubMed Mentions:
Dorsomedial prefrontal cortex activation disrupts Pavlovian incentive motivation. Front Behav Neurosci. 2022; 16:999320. Halbout B, Hutson C, Wassum KM, Ostlund SB. PMID: 36311857; PMCID: PMC9608868.

View in: PubMed Mentions:
Amygdala-cortical collaboration in reward learning and decision making. Elife. 2022 09 05; 11. Wassum KM. PMID: 36062909; PMCID: PMC9444241.

View in: PubMed Mentions: 11 Fields:
Bio Biology
The Medial Orbitofrontal Cortex-Basolateral Amygdala Circuit Regulates the Influence of Reward Cues on Adaptive Behavior and Choice. J Neurosci. 2021 08 25; 41(34):7267-7277. Lichtenberg NT, Sepe-Forrest L, Pennington ZT, Lamparelli AC, Greenfield VY, Wassum KM. PMID: 34272313; PMCID: PMC8387114.

View in: PubMed Mentions: 14 Fields:
Neu Neurology
Translation:Humans Animals Cells
A bidirectional corticoamygdala circuit for the encoding and retrieval of detailed reward memories. Elife. 2021 06 18; 10. Sias AC, Morse AK, Wang S, Greenfield VY, Goodpaster CM, Wrenn TM, Wikenheiser AM, Holley SM, Cepeda C, Levine MS, Wassum KM. PMID: 34142660; PMCID: PMC8266390.

View in: PubMed Mentions: 17 Fields:
Bio Biology
Translation:Animals
Capturing habitualness of drinking and smoking behavior in humans. Drug Alcohol Depend. 2020 02 01; 207:107738. Ray LA, Du H, Grodin E, Bujarski S, Meredith L, Ho D, Nieto S, Wassum K. PMID: 31816490; PMCID: PMC8063853.

View in: PubMed Mentions: 8 Fields:
Sub Substance-Related Disorders
Translation:Humans
Mesolimbic dopamine projections mediate cue-motivated reward seeking but not reward retrieval in rats. Elife. 2019 05 20; 8. Halbout B, Marshall AT, Azimi A, Liljeholm M, Mahler SV, Wassum KM, Ostlund SB. PMID: 31107241; PMCID: PMC6548499.

View in: PubMed Mentions: 23 Fields:
Bio Biology
Translation:Animals Cells
Distinct cortical-amygdala projections drive reward value encoding and retrieval. Nat Neurosci. 2019 05; 22(5):762-769. Malvaez M, Shieh C, Murphy MD, Greenfield VY, Wassum KM. PMID: 30962632; PMCID: PMC6486448.

View in: PubMed Mentions: 70 Fields:
Neu Neurology
Translation:Animals
Nucleus Accumbens Cholinergic Interneurons Oppose Cue-Motivated Behavior. Biol Psychiatry. 2019 09 01; 86(5):388-396. Collins AL, Aitken TJ, Huang IW, Shieh C, Greenfield VY, Monbouquette HG, Ostlund SB, Wassum KM. PMID: 30955842; PMCID: PMC7003647.

View in: PubMed Mentions: 35 Fields:
Psy Psychiatry Psy Psychophysiology
Translation:Animals Cells
Clarifying punishment. Neuropsychopharmacology. 2018 07; 43(8):1633-1634. Wassum KM. PMID: 29728646; PMCID: PMC6006317.

View in: PubMed Mentions: 1 Fields:
Neu Neurology Psy Psychopharmacology
Translation:Humans
Habits Are Negatively Regulated by Histone Deacetylase 3 in the Dorsal Striatum. Biol Psychiatry. 2018 09 01; 84(5):383-392. Malvaez M, Greenfield VY, Matheos DP, Angelillis NA, Murphy MD, Kennedy PJ, Wood MA, Wassum KM. PMID: 29571524; PMCID: PMC6082729.

View in: PubMed Mentions: 28 Fields:
Psy Psychiatry Psy Psychophysiology
Translation:Animals Cells
Regulation of habit formation in the dorsal striatum. Curr Opin Behav Sci. 2018 Apr; 20:67-74. Malvaez M, Wassum KM. PMID: 29713658; PMCID: PMC5920535.

View in: PubMed Mentions: 32
Basolateral Amygdala to Orbitofrontal Cortex Projections Enable Cue-Triggered Reward Expectations. J Neurosci. 2017 08 30; 37(35):8374-8384. Lichtenberg NT, Pennington ZT, Holley SM, Greenfield VY, Cepeda C, Levine MS, Wassum KM. PMID: 28743727; PMCID: PMC5577854.

View in: PubMed Mentions: 85 Fields:
Neu Neurology
Translation:Animals
Optogenetic excitation of cholinergic inputs to hippocampus primes future contextual fear associations. Sci Rep. 2017 05 24; 7(1):2333. Hersman S, Cushman J, Lemelson N, Wassum K, Lotfipour S, Fanselow MS. PMID: 28539613; PMCID: PMC5443779.

View in: PubMed Mentions: 14 Fields:
Sci Science
Translation:Animals
Amygdala mu-opioid receptors mediate the motivating influence of cue-triggered reward expectations. Eur J Neurosci. 2017 02; 45(3):381-387. Lichtenberg NT, Wassum KM. PMID: 27862489; PMCID: PMC5293612.

View in: PubMed Mentions: 12 Translation:Animals
Modulation of cue-triggered reward seeking by cholinergic signaling in the dorsomedial striatum. Eur J Neurosci. 2017 02; 45(3):358-364. Ostlund SB, Liu AT, Wassum KM, Maidment NT. PMID: 27813263; PMCID: PMC5293608.

View in: PubMed Mentions: 3 Translation:Animals
Nucleus Accumbens Acetylcholine Receptors Modulate Dopamine and Motivation. Neuropsychopharmacology. 2016 11; 41(12):2830-2838. Collins AL, Aitken TJ, Greenfield VY, Ostlund SB, Wassum KM. PMID: 27240658; PMCID: PMC5061892.

View in: PubMed Mentions: 40 Fields:
Neu Neurology Psy Psychopharmacology
Translation:Animals
Corrigendum: Basolateral amygdala rapid glutamate release encodes an outcome-specific representation vital for reward-predictive cues to selectively invigorate reward-seeking actions. Sci Rep. 2016 Feb 15; 6:20891. Malvaez M, Greenfield VY, Wang AS, Yorita AM, Feng L, Linker KE, Monbouquette HG, Wassum KM. PMID: 26876785; PMCID: PMC4753403.

View in: PubMed Mentions: Fields:
Sci Science
Dynamic mesolimbic dopamine signaling during action sequence learning and expectation violation. Sci Rep. 2016 Feb 12; 6:20231. Collins AL, Greenfield VY, Bye JK, Linker KE, Wang AS, Wassum KM. PMID: 26869075; PMCID: PMC4751524.

View in: PubMed Mentions: 50 Fields:
Sci Science
Translation:Animals Cells
Nucleus accumbens core dopamine signaling tracks the need-based motivational value of food-paired cues. J Neurochem. 2016 Mar; 136(5):1026-36. Aitken TJ, Greenfield VY, Wassum KM. PMID: 26715366; PMCID: PMC4819964.

View in: PubMed Mentions: 43 Fields:
Che Chemistry Neu Neurology
Translation:Animals Cells
The Origins and Organization of Vertebrate Pavlovian Conditioning. Cold Spring Harb Perspect Biol. 2015 Nov 09; 8(1):a021717. Fanselow MS, Wassum KM. PMID: 26552417; PMCID: PMC4691796.

View in: PubMed Mentions: 50 Fields:
Bio Biology
Translation:Animals
The basolateral amygdala in reward learning and addiction. Neurosci Biobehav Rev. 2015 Oct; 57:271-83. Wassum KM, Izquierdo A. PMID: 26341938; PMCID: PMC4681295.

View in: PubMed Mentions: 135 Fields:
Beh Behavioral Sciences Neu Neurology
Translation:Humans Animals
Basolateral amygdala rapid glutamate release encodes an outcome-specific representation vital for reward-predictive cues to selectively invigorate reward-seeking actions. Sci Rep. 2015 Jul 27; 5:12511. Malvaez M, Greenfield VY, Wang AS, Yorita AM, Feng L, Linker KE, Monbouquette HG, Wassum KM. PMID: 26212790; PMCID: PMC4648450.

View in: PubMed Mentions: 25 Fields:
Sci Science
Translation:Animals
Probing the neurochemical correlates of motivation and decision making. ACS Chem Neurosci. 2015 Jan 21; 6(1):11-3. Wassum KM, Phillips PE. PMID: 25526380; PMCID: PMC4304500.

View in: PubMed Mentions: 2 Fields:
Neu Neurology
Translation:Humans Animals
Inflated reward value in early opiate withdrawal. Addict Biol. 2016 Mar; 21(2):221-33. Wassum KM, Greenfield VY, Linker KE, Maidment NT, Ostlund SB. PMID: 25081350; PMCID: PMC4312551.

View in: PubMed Mentions: 9 Fields:
Sub Substance-Related Disorders
Translation:Animals
Phasic mesolimbic dopamine signaling encodes the facilitation of incentive motivation produced by repeated cocaine exposure. Neuropsychopharmacology. 2014 Sep; 39(10):2441-9. Ostlund SB, LeBlanc KH, Kosheleff AR, Wassum KM, Maidment NT. PMID: 24804846; PMCID: PMC4138756.

View in: PubMed Mentions: 46 Fields:
Neu Neurology Psy Psychopharmacology
Translation:Animals
Phasic mesolimbic dopamine release tracks reward seeking during expression of Pavlovian-to-instrumental transfer. Biol Psychiatry. 2013 Apr 15; 73(8):747-55. Wassum KM, Ostlund SB, Loewinger GC, Maidment NT. PMID: 23374641; PMCID: PMC3615104.

View in: PubMed Mentions: 47 Fields:
Psy Psychiatry Psy Psychophysiology
Translation:Animals
Electrochemically deposited iridium oxide reference electrode integrated with an electroenzymatic glutamate sensor on a multi-electrode array microprobe. Biosens Bioelectron. 2013 Apr 15; 42:256-60. Tolosa VM, Wassum KM, Maidment NT, Monbouquette HG. PMID: 23208095.

View in: PubMed Mentions: 19 Fields:
Bio Biotechnology
Transient extracellular glutamate events in the basolateral amygdala track reward-seeking actions. J Neurosci. 2012 Feb 22; 32(8):2734-46. Wassum KM, Tolosa VM, Tseng TC, Balleine BW, Monbouquette HG, Maidment NT. PMID: 22357857; PMCID: PMC3548241.

View in: PubMed Mentions: 30 Fields:
Neu Neurology
Translation:Animals Cells
Phasic mesolimbic dopamine signaling precedes and predicts performance of a self-initiated action sequence task. Biol Psychiatry. 2012 May 15; 71(10):846-54. Wassum KM, Ostlund SB, Maidment NT. PMID: 22305286; PMCID: PMC3471807.

View in: PubMed Mentions: 53 Fields:
Psy Psychiatry Psy Psychophysiology
Translation:Animals Cells
Differential dependence of Pavlovian incentive motivation and instrumental incentive learning processes on dopamine signaling. Learn Mem. 2011; 18(7):475-83. Wassum KM, Ostlund SB, Balleine BW, Maidment NT. PMID: 21693635; PMCID: PMC3125614.

View in: PubMed Mentions: 80 Fields:
Neu Neurology
Translation:Animals Cells
Micro-opioid receptor activation in the basolateral amygdala mediates the learning of increases but not decreases in the incentive value of a food reward. J Neurosci. 2011 Feb 02; 31(5):1591-9. Wassum KM, Cely IC, Balleine BW, Maidment NT. PMID: 21289167; PMCID: PMC3081716.

View in: PubMed Mentions: 37 Fields:
Neu Neurology
Translation:Animals
Extracellular dopamine levels in striatal subregions track shifts in motivation and response cost during instrumental conditioning. J Neurosci. 2011 Jan 05; 31(1):200-7. Ostlund SB, Wassum KM, Murphy NP, Balleine BW, Maidment NT. PMID: 21209205; PMCID: PMC3078720.

View in: PubMed Mentions: 45 Fields:
Neu Neurology
Translation:Animals Cells
Disruption of endogenous opioid activity during instrumental learning enhances habit acquisition. Neuroscience. 2009 Oct 20; 163(3):770-80. Wassum KM, Cely IC, Maidment NT, Balleine BW. PMID: 19619616; PMCID: PMC3065789.

View in: PubMed Mentions: 20 Fields:
Neu Neurology
Translation:Animals
Distinct opioid circuits determine the palatability and the desirability of rewarding events. Proc Natl Acad Sci U S A. 2009 Jul 28; 106(30):12512-7. Wassum KM, Ostlund SB, Maidment NT, Balleine BW. PMID: 19597155; PMCID: PMC2718390.

View in: PubMed Mentions: 80 Fields:
Sci Science
Translation:Animals
International Narcotics Research Conference - 39th Annual Meeting. IDrugs. 2008 Sep; 11(9):646-9. Wassum KM, Evans CJ. PMID: 18763214; PMCID: PMC4445826.

View in: PubMed Mentions: Fields:
Pha Pharmacology
Translation:Humans Animals
Silicon Wafer-Based Platinum Microelectrode Array Biosensor for Near Real-Time Measurement of Glutamate in Vivo. Sensors (Basel). 2008; 8(8):5023-5036. Wassum KM, Tolosa VM, Wang J, Walker E, Monbouquette HG, Maidment NT. PMID: 19543440; PMCID: PMC2699285.

View in: PubMed Mentions: 46 Fields:
Bio Biotechnology Tec Technology
Dopamine release is heterogeneous within microenvironments of the rat nucleus accumbens. Eur J Neurosci. 2007 Oct; 26(7):2046-54. Wightman RM, Heien ML, Wassum KM, Sombers LA, Aragona BJ, Khan AS, Ariansen JL, Cheer JF, Phillips PE, Carelli RM. PMID: 17868375.

View in: PubMed Mentions: 111 Translation:Animals Cells
Phasic dopamine release evoked by abused substances requires cannabinoid receptor activation. J Neurosci. 2007 Jan 24; 27(4):791-5. Cheer JF, Wassum KM, Sombers LA, Heien ML, Ariansen JL, Aragona BJ, Phillips PE, Wightman RM. PMID: 17251418; PMCID: PMC6672925.

View in: PubMed Mentions: 187 Fields:
Neu Neurology
Translation:Animals
Cannabinoid modulation of electrically evoked pH and oxygen transients in the nucleus accumbens of awake rats. J Neurochem. 2006 May; 97(4):1145-54. Cheer JF, Wassum KM, Wightman RM. PMID: 16686693.

View in: PubMed Mentions: 13 Fields:
Che Chemistry Neu Neurology
Translation:Animals
Real-time measurement of dopamine fluctuations after cocaine in the brain of behaving rats. Proc Natl Acad Sci U S A. 2005 Jul 19; 102(29):10023-8. Heien ML, Khan AS, Ariansen JL, Cheer JF, Phillips PE, Wassum KM, Wightman RM. PMID: 16006505; PMCID: PMC1177422.

View in: PubMed Mentions: 196 Fields:
Sci Science
Translation:Animals Cells
Cannabinoids enhance subsecond dopamine release in the nucleus accumbens of awake rats. J Neurosci. 2004 May 05; 24(18):4393-400. Cheer JF, Wassum KM, Heien ML, Phillips PE, Wightman RM. PMID: 15128853; PMCID: PMC6729440.

View in: PubMed Mentions: 159 Fields:
Neu Neurology
Translation:Animals Cells