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Silva, Alcino Jose

Title(s)Professor, Neurobiology
Phone46345
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    Other Positions
    Title(s)Professor, Psychiatry And Biobehavioral Sciences


    Collapse Research 
    Collapse Research Activities and Funding
    CCR5 Activation and Cognitive Dysfunction Caused by HIV-Proteins
    NIH/NINDS R01NS106969Sep 30, 2017 - May 31, 2022
    Role: Principal Investigator
    Molecular, Cellular and Circuit Mechnisms for Memory-linking deficits in Psychiatric Disorders
    NIH/NIMH R01MH113071Jun 1, 2017 - May 31, 2022
    Role: Principal Investigator
    Building and sharing next generation open-source, wireless, multichannel miniaturized microscopes for imaging activity in freely behaving mice
    NIH/NINDS U01NS094286Sep 30, 2015 - Jun 30, 2018
    Role: Co-Principal Investigator
    Forward Genetic Approaches to Mechanisms of Cortical Plasticity
    NIH/NIMH P50MH077972Apr 1, 2007 - Mar 31, 2012
    Role: Principal Investigator
    Molecular and Cellular Cognition Meeting
    NIH/NIMH R13MH073327Sep 22, 2004 - Jul 31, 2007
    Role: Principal Investigator
    AGE RELATED LEARNING AND MEMORY IMPROVEMENTS
    NIH/NIA R01AG017499Mar 1, 2000 - Feb 28, 2005
    Role: Principal Investigator
    PHENOTYPING THE MOUSE NERVOUS SYSTEM AND BEHAVIOR
    NIH/NIMH R01MH061094Dec 6, 1999 - Nov 30, 2002
    Role: Principal Investigator
    Mechanisms for Cognitive Dysfunction in Noonan Syndrome
    NIH/NIMH R01MH084315Sep 4, 1998 - Nov 30, 2020
    Role: Principal Investigator
    Mechanisms for Neurological Dysfunction in NF1
    NIH/NINDS R01NS038480Sep 4, 1998 - Feb 28, 2003
    Role: Principal Investigator
    Gene Targeting Approaches to Learning and Memory Studies
    NIH/NIA R37AG013622Jul 25, 1995 - Mar 31, 2017
    Role: Principal Investigator
    Molecular, cellular and circuit mechanisms for age-related deficits in memory-linking
    NIH/NIA R01AG013622Jul 25, 1995 - Jun 30, 2000
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Luchetti A, Chowdhury A, Silva AJ. Getting the full picture. Elife. 2019 03 26; 8. PMID: 30912744.
      View in: PubMed
    2. Joy MT, Ben Assayag E, Shabashov-Stone D, Liraz-Zaltsman S, Mazzitelli J, Arenas M, Abduljawad N, Kliper E, Korczyn AD, Thareja NS, Kesner EL, Zhou M, Huang S, Silva TK, Katz N, Bornstein NM, Silva AJ, Shohami E, Carmichael ST. CCR5 Is a Therapeutic Target for Recovery after Stroke and Traumatic Brain Injury. Cell. 2019 02 21; 176(5):1143-1157.e13. PMID: 30794775.
      View in: PubMed
    3. Aharoni D, Khakh BS, Silva AJ, Golshani P. All the light that we can see: a new era in miniaturized microscopy. Nat Methods. 2019 Jan; 16(1):11-13. PMID: 30573833.
      View in: PubMed
    4. Matiasz NJ, Wood J, Doshi P, Speier W, Beckemeyer B, Wang W, Hsu W, Silva AJ. ResearchMaps.org for integrating and planning research. PLoS One. 2018; 13(5):e0195271. PMID: 29723213.
      View in: PubMed
    5. Lisman J, Cooper K, Sehgal M, Silva AJ. Memory formation depends on both synapse-specific modifications of synaptic strength and cell-specific increases in excitability. Nat Neurosci. 2018 03; 21(3):309-314. PMID: 29434376.
      View in: PubMed
    6. Frank AC, Huang S, Zhou M, Gdalyahu A, Kastellakis G, Silva TK, Lu E, Wen X, Poirazi P, Trachtenberg JT, Silva AJ. Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory. Nat Commun. 2018 01 29; 9(1):422. PMID: 29379017.
      View in: PubMed
    7. Silva AJ. Miniaturized two-photon microscope: seeing clearer and deeper into the brain. Light Sci Appl. 2017 Aug; 6(8):e17104. PMID: 30167288.
      View in: PubMed
    8. Jonas RK, Roh E, Montojo CA, Pacheco LA, Rosser T, Silva AJ, Bearden CE. Risky Decision Making in Neurofibromatosis Type 1: An Exploratory Study. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Mar; 2(2):170-179. PMID: 28736755.
      View in: PubMed
    9. Zhou M, Greenhill S, Huang S, Silva TK, Sano Y, Wu S, Cai Y, Nagaoka Y, Sehgal M, Cai DJ, Lee YS, Fox K, Silva AJ. CCR5 is a suppressor for cortical plasticity and hippocampal learning and memory. Elife. 2016 12 20; 5. PMID: 27996938.
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    10. Payne JM, Barton B, Ullrich NJ, Cantor A, Hearps SJ, Cutter G, Rosser T, Walsh KS, Gioia GA, Wolters PL, Tonsgard J, Schorry E, Viskochil D, Klesse L, Fisher M, Gutmann DH, Silva AJ, Hunter SJ, Rey-Casserly C, Cantor NL, Byars AW, Stavinoha PL, Ackerson JD, Armstrong CL, Isenberg J, O'Neil SH, Packer RJ, Korf B, Acosta MT, North KN. Randomized placebo-controlled study of lovastatin in children with neurofibromatosis type 1. Neurology. 2016 Dec 13; 87(24):2575-2584. PMID: 27956565.
      View in: PubMed
    11. Silva AJ, Müller KR. Corrigendum: The need for novel informatics tools for integrating and planning research in molecular and cellular cognition. Learn Mem. 2016 11; 23(11):668. PMID: 27918288.
      View in: PubMed
    12. Rogerson T, Jayaprakash B, Cai DJ, Sano Y, Lee YS, Zhou Y, Bekal P, Deisseroth K, Silva AJ. Molecular and Cellular Mechanisms for Trapping and Activating Emotional Memories. PLoS One. 2016; 11(8):e0161655. PMID: 27579481.
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    13. Cai DJ, Aharoni D, Shuman T, Shobe J, Biane J, Song W, Wei B, Veshkini M, La-Vu M, Lou J, Flores SE, Kim I, Sano Y, Zhou M, Baumgaertel K, Lavi A, Kamata M, Tuszynski M, Mayford M, Golshani P, Silva AJ. A shared neural ensemble links distinct contextual memories encoded close in time. Nature. 2016 06 02; 534(7605):115-8. PMID: 27251287.
      View in: PubMed
    14. Izquierdo A, Silva AJ. Hijacking translation in addiction. Elife. 2016 Mar 01; 5. PMID: 26929992.
      View in: PubMed
    15. Bearden CE, Hellemann GS, Rosser T, Montojo C, Jonas R, Enrique N, Pacheco L, Hussain SA, Wu JY, Ho JS, McGough JJ, Sugar CA, Silva AJ. A randomized placebo-controlled lovastatin trial for neurobehavioral function in neurofibromatosis I. Ann Clin Transl Neurol. 2016 04; 3(4):266-79. PMID: 27081657.
      View in: PubMed
    16. Tomson SN, Schreiner MJ, Narayan M, Rosser T, Enrique N, Silva AJ, Allen GI, Bookheimer SY, Bearden CE. Resting state functional MRI reveals abnormal network connectivity in neurofibromatosis 1. Hum Brain Mapp. 2015 Nov; 36(11):4566-81. PMID: 26304096.
      View in: PubMed
    17. Silva AJ, Müller KR. The need for novel informatics tools for integrating and planning research in molecular and cellular cognition. Learn Mem. 2015 Sep; 22(9):494-8. PMID: 26286658.
      View in: PubMed
    18. Sano Y, Shobe JL, Zhou M, Huang S, Shuman T, Cai DJ, Golshani P, Kamata M, Silva AJ. CREB regulates memory allocation in the insular cortex. Curr Biol. 2014 Dec 01; 24(23):2833-7. PMID: 25454591.
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    19. Lee YS, Ehninger D, Zhou M, Oh JY, Kang M, Kwak C, Ryu HH, Butz D, Araki T, Cai Y, Balaji J, Sano Y, Nam CI, Kim HK, Kaang BK, Burger C, Neel BG, Silva AJ. Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome. Nat Neurosci. 2014 Dec; 17(12):1736-43. PMID: 25383899.
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    20. Le Belle JE, Sperry J, Ngo A, Ghochani Y, Laks DR, López-Aranda M, Silva AJ, Kornblum HI. Maternal inflammation contributes to brain overgrowth and autism-associated behaviors through altered redox signaling in stem and progenitor cells. Stem Cell Reports. 2014 Nov 11; 3(5):725-34. PMID: 25418720.
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    21. Achterberg KG, Buitendijk GH, Kool MJ, Goorden SM, Post L, Slump DE, Silva AJ, van Woerden GM, Kushner SA, Elgersma Y. Temporal and region-specific requirements of aCaMKII in spatial and contextual learning. J Neurosci. 2014 Aug 20; 34(34):11180-7. PMID: 25143599.
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    22. Czajkowski R, Jayaprakash B, Wiltgen B, Rogerson T, Guzman-Karlsson MC, Barth AL, Trachtenberg JT, Silva AJ. Encoding and storage of spatial information in the retrosplenial cortex. Proc Natl Acad Sci U S A. 2014 Jun 10; 111(23):8661-6. PMID: 24912150.
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    23. Rogerson T, Cai DJ, Frank A, Sano Y, Shobe J, Lopez-Aranda MF, Silva AJ. Synaptic tagging during memory allocation. Nat Rev Neurosci. 2014 Mar; 15(3):157-69. PMID: 24496410.
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    24. Landreth A, Silva AJ. The need for research maps to navigate published work and inform experiment planning. Neuron. 2013 Aug 07; 79(3):411-5. PMID: 23931992.
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    25. Zhou M, Li W, Huang S, Song J, Kim JY, Tian X, Kang E, Sano Y, Liu C, Balaji J, Wu S, Zhou Y, Zhou Y, Parivash SN, Ehninger D, He L, Song H, Ming GL, Silva AJ. mTOR Inhibition ameliorates cognitive and affective deficits caused by Disc1 knockdown in adult-born dentate granule neurons. Neuron. 2013 Feb 20; 77(4):647-54. PMID: 23439118.
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    26. Gdalyahu A, Tring E, Polack PO, Gruver R, Golshani P, Fanselow MS, Silva AJ, Trachtenberg JT. Associative fear learning enhances sparse network coding in primary sensory cortex. Neuron. 2012 Jul 12; 75(1):121-32. PMID: 22794266.
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    27. Cho J, Bhatt R, Elgersma Y, Silva AJ. a-Calcium calmodulin kinase II modulates the temporal structure of hippocampal bursting patterns. PLoS One. 2012; 7(2):e31649. PMID: 22363696.
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    28. Silva AJ. Obituary: A career that transformed neuroscience. Brain Res Bull. 2011 Nov 25; 86(5-6):285-6. PMID: 21930192.
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    29. Kaneko M, Cheetham CE, Lee YS, Silva AJ, Stryker MP, Fox K. Constitutively active H-ras accelerates multiple forms of plasticity in developing visual cortex. Proc Natl Acad Sci U S A. 2010 Nov 02; 107(44):19026-31. PMID: 20937865.
      View in: PubMed
    30. Ehninger D, Silva AJ. Increased levels of anxiety-related behaviors in a Tsc2 dominant negative transgenic mouse model of tuberous sclerosis. Behav Genet. 2011 May; 41(3):357-63. PMID: 20882401.
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    31. Wiltgen BJ, Zhou M, Cai Y, Balaji J, Karlsson MG, Parivash SN, Li W, Silva AJ. The hippocampus plays a selective role in the retrieval of detailed contextual memories. Curr Biol. 2010 Aug 10; 20(15):1336-44. PMID: 20637623.
      View in: PubMed
    32. Shilyansky C, Karlsgodt KH, Cummings DM, Sidiropoulou K, Hardt M, James AS, Ehninger D, Bearden CE, Poirazi P, Jentsch JD, Cannon TD, Levine MS, Silva AJ. Neurofibromin regulates corticostriatal inhibitory networks during working memory performance. Proc Natl Acad Sci U S A. 2010 Jul 20; 107(29):13141-6. PMID: 20624961.
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    33. Buard I, Coultrap SJ, Freund RK, Lee YS, Dell'Acqua ML, Silva AJ, Bayer KU. CaMKII "autonomy" is required for initiating but not for maintaining neuronal long-term information storage. J Neurosci. 2010 Jun 16; 30(24):8214-20. PMID: 20554872.
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    34. Matynia A, Ng CH, Dansithong W, Chiang A, Silva AJ, Reddy S. Muscleblind1, but not Dmpk or Six5, contributes to a complex phenotype of muscular and motivational deficits in mouse models of myotonic dystrophy. PLoS One. 2010 Mar 25; 5(3):e9857. PMID: 20360842.
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    35. Feng J, Zhou Y, Campbell SL, Le T, Li E, Sweatt JD, Silva AJ, Fan G. Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. Nat Neurosci. 2010 Apr; 13(4):423-30. PMID: 20228804.
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    36. Silva AJ, Zhou Y, Rogerson T, Shobe J, Balaji J. Molecular and cellular approaches to memory allocation in neural circuits. Science. 2009 Oct 16; 326(5951):391-5. PMID: 19833959.
      View in: PubMed
    37. Zhou Y, Won J, Karlsson MG, Zhou M, Rogerson T, Balaji J, Neve R, Poirazi P, Silva AJ. CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala. Nat Neurosci. 2009 Nov; 12(11):1438-43. PMID: 19783993.
      View in: PubMed
    38. Ehninger D, Silva AJ. Genetics and neuropsychiatric disorders: treatment during adulthood. Nat Med. 2009 Aug; 15(8):849-50. PMID: 19661989.
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    39. Huynh DP, Maalouf M, Silva AJ, Schweizer FE, Pulst SM. Dissociated fear and spatial learning in mice with deficiency of ataxin-2. PLoS One. 2009 Jul 20; 4(7):e6235. PMID: 19617910.
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    40. Silva AJ, Ehninger D. Adult reversal of cognitive phenotypes in neurodevelopmental disorders. J Neurodev Disord. 2009 Jun; 1(2):150-7. PMID: 19812701.
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    41. Hutnick LK, Golshani P, Namihira M, Xue Z, Matynia A, Yang XW, Silva AJ, Schweizer FE, Fan G. DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation. Hum Mol Genet. 2009 Aug 01; 18(15):2875-88. PMID: 19433415.
      View in: PubMed
    42. Lee YS, Silva AJ. The molecular and cellular biology of enhanced cognition. Nat Rev Neurosci. 2009 Feb; 10(2):126-40. PMID: 19153576.
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    43. Ehninger D, Li W, Fox K, Stryker MP, Silva AJ. Reversing neurodevelopmental disorders in adults. Neuron. 2008 Dec 26; 60(6):950-60. PMID: 19109903.
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    44. Cui Y, Costa RM, Murphy GG, Elgersma Y, Zhu Y, Gutmann DH, Parada LF, Mody I, Silva AJ. Neurofibromin regulation of ERK signaling modulates GABA release and learning. Cell. 2008 Oct 31; 135(3):549-60. PMID: 18984165.
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    45. Kimura R, Silva AJ, Ohno M. Autophosphorylation of alphaCaMKII is differentially involved in new learning and unlearning mechanisms of memory extinction. Learn Mem. 2008 Nov; 15(11):837-43. PMID: 18984565.
      View in: PubMed
    46. Ehninger D, Han S, Shilyansky C, Zhou Y, Li W, Kwiatkowski DJ, Ramesh V, Silva AJ. Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis. Nat Med. 2008 Aug; 14(8):843-8. PMID: 18568033.
      View in: PubMed
    47. Matynia A, Anagnostaras SG, Wiltgen BJ, Lacuesta M, Fanselow MS, Silva AJ. A high through-put reverse genetic screen identifies two genes involved in remote memory in mice. PLoS One. 2008 May 07; 3(5):e2121. PMID: 18464936.
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    48. Silva AJ. The science of research: the principles underlying the discovery of cognitive and other biological mechanisms. J Physiol Paris. 2007 Jul-Nov; 101(4-6):203-13. PMID: 18280120.
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    49. Zhou Y, Takahashi E, Li W, Halt A, Wiltgen B, Ehninger D, Li GD, Hell JW, Kennedy MB, Silva AJ. Interactions between the NR2B receptor and CaMKII modulate synaptic plasticity and spatial learning. J Neurosci. 2007 Dec 12; 27(50):13843-53. PMID: 18077696.
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    50. Li W, Zhou Y, Jentsch JD, Brown RA, Tian X, Ehninger D, Hennah W, Peltonen L, Lönnqvist J, Huttunen MO, Kaprio J, Trachtenberg JT, Silva AJ, Cannon TD. Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18280-5. PMID: 17984054.
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    51. Won J, Silva AJ. Molecular and cellular mechanisms of memory allocation in neuronetworks. Neurobiol Learn Mem. 2008 Mar; 89(3):285-92. PMID: 17962049.
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    52. Hojjati MR, van Woerden GM, Tyler WJ, Giese KP, Silva AJ, Pozzo-Miller L, Elgersma Y. Kinase activity is not required for alphaCaMKII-dependent presynaptic plasticity at CA3-CA1 synapses. Nat Neurosci. 2007 Sep; 10(9):1125-7. PMID: 17660813.
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    53. Han JH, Kushner SA, Yiu AP, Cole CJ, Matynia A, Brown RA, Neve RL, Guzowski JF, Silva AJ, Josselyn SA. Neuronal competition and selection during memory formation. Science. 2007 Apr 20; 316(5823):457-60. PMID: 17446403.
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    54. Wiltgen BJ, Silva AJ. Memory for context becomes less specific with time. Learn Mem. 2007 Apr; 14(4):313-7. PMID: 17522020.
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    55. Murphy GG, Rahnama NP, Silva AJ. Investigation of age-related cognitive decline using mice as a model system: behavioral correlates. Am J Geriatr Psychiatry. 2006 Dec; 14(12):1004-11. PMID: 17138807.
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    56. Murphy GG, Shah V, Hell JW, Silva AJ. Investigation of age-related cognitive decline using mice as a model system: neurophysiological correlates. Am J Geriatr Psychiatry. 2006 Dec; 14(12):1012-21. PMID: 17138808.
      View in: PubMed
    57. Frankland PW, Ding HK, Takahashi E, Suzuki A, Kida S, Silva AJ. Stability of recent and remote contextual fear memory. Learn Mem. 2006 Jul-Aug; 13(4):451-7. PMID: 16882861.
      View in: PubMed
    58. Ohno M, Sametsky EA, Silva AJ, Disterhoft JF. Differential effects of alphaCaMKII mutation on hippocampal learning and changes in intrinsic neuronal excitability. Eur J Neurosci. 2006 Apr; 23(8):2235-40. PMID: 16630070.
      View in: PubMed
    59. Nagy V, Bozdagi O, Matynia A, Balcerzyk M, Okulski P, Dzwonek J, Costa RM, Silva AJ, Kaczmarek L, Huntley GW. Matrix metalloproteinase-9 is required for hippocampal late-phase long-term potentiation and memory. J Neurosci. 2006 Feb 15; 26(7):1923-34. PMID: 16481424.
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    60. Chen AP, Ohno M, Giese KP, Kühn R, Chen RL, Silva AJ. Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory. J Neurosci Res. 2006 Jan; 83(1):28-38. PMID: 16342120.
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    61. Li W, Cui Y, Kushner SA, Brown RA, Jentsch JD, Frankland PW, Cannon TD, Silva AJ. The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1. Curr Biol. 2005 Nov 08; 15(21):1961-7. PMID: 16271875.
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    62. Kushner SA, Elgersma Y, Murphy GG, Jaarsma D, van Woerden GM, Hojjati MR, Cui Y, LeBoutillier JC, Marrone DF, Choi ES, De Zeeuw CI, Petit TL, Pozzo-Miller L, Silva AJ. Modulation of presynaptic plasticity and learning by the H-ras/extracellular signal-regulated kinase/synapsin I signaling pathway. J Neurosci. 2005 Oct 19; 25(42):9721-34. PMID: 16237176.
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    63. Costa RM, Drew C, Silva AJ. Notch to remember. Trends Neurosci. 2005 Aug; 28(8):429-35. PMID: 15922461.
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    64. Ohno M, Tseng W, Silva AJ, Disterhoft JF. Trace eyeblink conditioning requires the hippocampus but not autophosphorylation of alphaCaMKII in mice. Learn Mem. 2005 May-Jun; 12(3):211-5. PMID: 15897256.
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    65. Murphy GG, Fedorov NB, Giese KP, Ohno M, Friedman E, Chen R, Silva AJ. Increased neuronal excitability, synaptic plasticity, and learning in aged Kvbeta1.1 knockout mice. Curr Biol. 2004 Nov 09; 14(21):1907-15. PMID: 15530391.
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    66. Wiltgen BJ, Brown RA, Talton LE, Silva AJ. New circuits for old memories: the role of the neocortex in consolidation. Neuron. 2004 Sep 30; 44(1):101-8. PMID: 15450163.
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    67. Israely I, Costa RM, Xie CW, Silva AJ, Kosik KS, Liu X. Deletion of the neuron-specific protein delta-catenin leads to severe cognitive and synaptic dysfunction. Curr Biol. 2004 Sep 21; 14(18):1657-63. PMID: 15380068.
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    68. Suzuki A, Josselyn SA, Frankland PW, Masushige S, Silva AJ, Kida S. Memory reconsolidation and extinction have distinct temporal and biochemical signatures. J Neurosci. 2004 May 19; 24(20):4787-95. PMID: 15152039.
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    69. Frankland PW, Bontempi B, Talton LE, Kaczmarek L, Silva AJ. The involvement of the anterior cingulate cortex in remote contextual fear memory. Science. 2004 May 07; 304(5672):881-3. PMID: 15131309.
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    70. Brown R, Silva AJ. Molecular and cellular cognition; the unraveling of memory retrieval. Cell. 2004 Apr 02; 117(1):3-4. PMID: 15066276.
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    71. Frankland PW, Josselyn SA, Anagnostaras SG, Kogan JH, Takahashi E, Silva AJ. Consolidation of CS and US representations in associative fear conditioning. Hippocampus. 2004; 14(5):557-69. PMID: 15301434.
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    72. Wang J, Ren K, Pérez J, Silva AJ, Peña de Ortiz S. The antimetabolite ara-CTP blocks long-term memory of conditioned taste aversion. Learn Mem. 2003 Nov-Dec; 10(6):503-9. PMID: 14657261.
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    73. Costa RM, Honjo T, Silva AJ. Learning and memory deficits in Notch mutant mice. Curr Biol. 2003 Aug 05; 13(15):1348-54. PMID: 12906797.
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    74. Frankland PW, Ohno M, Takahashi E, Chen AR, Costa RM, Kushner SA, Silva AJ. Pharmacologically regulated induction of silent mutations (PRISM): combined pharmacological and genetic approaches for learning and memory. Neuroscientist. 2003 Apr; 9(2):104-9. PMID: 12708614.
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    75. Dhaka A, Costa RM, Hu H, Irvin DK, Patel A, Kornblum HI, Silva AJ, O'Dell TJ, Colicelli J. The RAS effector RIN1 modulates the formation of aversive memories. J Neurosci. 2003 Feb 01; 23(3):748-57. PMID: 12574403.
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    76. Silva AJ. Molecular and cellular cognitive studies of the role of synaptic plasticity in memory. J Neurobiol. 2003 Jan; 54(1):224-37. PMID: 12486706.
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    77. Anagnostaras SG, Murphy GG, Hamilton SE, Mitchell SL, Rahnama NP, Nathanson NM, Silva AJ. Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice. Nat Neurosci. 2003 Jan; 6(1):51-8. PMID: 12483218.
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    78. Costa RM, Silva AJ. Mouse models of neurofibromatosis type I: bridging the GAP. Trends Mol Med. 2003 Jan; 9(1):19-23. PMID: 12524206.
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    79. Taha S, Hanover JL, Silva AJ, Stryker MP. Autophosphorylation of alphaCaMKII is required for ocular dominance plasticity. Neuron. 2002 Oct 24; 36(3):483-91. PMID: 12408850.
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    80. Elgersma Y, Fedorov NB, Ikonen S, Choi ES, Elgersma M, Carvalho OM, Giese KP, Silva AJ. Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning. Neuron. 2002 Oct 24; 36(3):493-505. PMID: 12408851.
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    81. Matynia A, Kushner SA, Silva AJ. Genetic approaches to molecular and cellular cognition: a focus on LTP and learning and memory. Annu Rev Genet. 2002; 36:687-720. PMID: 12429705.
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    82. Silva AJ, Josselyn SA. The molecules of forgetfulness. Nature. 2002 Aug 29; 418(6901):929-30. PMID: 12198533.
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    83. Costa RM, Silva AJ. Molecular and cellular mechanisms underlying the cognitive deficits associated with neurofibromatosis 1. J Child Neurol. 2002 Aug; 17(8):622-6; discussion 627-9, 646-51. PMID: 12403561.
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    84. Ohno M, Frankland PW, Silva AJ. A pharmacogenetic inducible approach to the study of NMDA/alphaCaMKII signaling in synaptic plasticity. Curr Biol. 2002 Apr 16; 12(8):654-6. PMID: 11967152.
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    85. Kida S, Josselyn SA, Peña de Ortiz S, Kogan JH, Chevere I, Masushige S, Silva AJ. CREB required for the stability of new and reactivated fear memories. Nat Neurosci. 2002 Apr; 5(4):348-55. PMID: 11889468.
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    86. Givogri MI, Costa RM, Schonmann V, Silva AJ, Campagnoni AT, Bongarzone ER. Central nervous system myelination in mice with deficient expression of Notch1 receptor. J Neurosci Res. 2002 Feb 01; 67(3):309-20. PMID: 11813235.
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    87. Costa RM, Federov NB, Kogan JH, Murphy GG, Stern J, Ohno M, Kucherlapati R, Jacks T, Silva AJ. Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1. Nature. 2002 Jan 31; 415(6871):526-30. PMID: 11793011.
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