Alicia Izquierdo

Title(s)	Professor, Psychology
School	College of Letters and Science
ORCID	0000-0001-9897-2091
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Neural coding of choice and outcome are modulated by uncertainty in orbitofrontal but not secondary motor cortex. bioRxiv. 2024 Nov 05. Romero-Sosa JL, Wikenheiser AM, Blair HT, Izquierdo A. PMID: 39574574; PMCID: PMC11580916.

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A common stay-on-goal mechanism in anterior cingulate cortex for information and effort choices. bioRxiv. 2024 Oct 23. González VV, Malvaez M, Yeghikian A, Wissing S, Sharpe M, Wassum KM, Izquierdo A. PMID: 39484586; PMCID: PMC11527009.

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A special role for anterior cingulate cortex, but not orbitofrontal cortex or basolateral amygdala, in choices involving information. Cereb Cortex. 2024 Apr 01; 34(4). González VV, Zhang Y, Ashikyan SA, Rickard A, Yassine I, Romero-Sosa JL, Blaisdell AP, Izquierdo A. PMID: 38610085; PMCID: PMC11014886.

View in: PubMed Mentions: 2 Fields:
Bra Brain
Translation:Humans Animals
Dissociable Contributions of Basolateral Amygdala and Ventrolateral Orbitofrontal Cortex to Flexible Learning Under Uncertainty. J Neurosci. 2024 01 10; 44(2). Aguirre CG, Woo JH, Romero-Sosa JL, Rivera ZM, Tejada AN, Munier JJ, Perez J, Goldfarb M, Das K, Gomez M, Ye T, Pannu J, Evans K, O'Neill PR, Spigelman I, Soltani A, Izquierdo A. PMID: 37968116; PMCID: PMC10860573.

View in: PubMed Mentions: 2 Fields:
Neu Neurology
Translation:Animals
A special role for anterior cingulate cortex, but not orbitofrontal cortex or basolateral amygdala, in choices involving information. bioRxiv. 2023 Dec 19. González VV, Ashikyan SA, Zhang Y, Rickard A, Yassine I, Romero-Sosa JL, Blaisdell AP, Izquierdo A. PMID: 37577596; PMCID: PMC10418268.

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Theta oscillations in anterior cingulate cortex and orbitofrontal cortex differentially modulate accuracy and speed in flexible reward learning. Oxf Open Neurosci. 2023; 2. Ye T, Romero-Sosa JL, Rickard A, Aguirre CG, Wikenheiser AM, Blair HT, Izquierdo A. PMID: 37456140; PMCID: PMC10348740.

View in: PubMed Mentions: 4
Mechanisms of adjustments to different types of uncertainty in the reward environment across mice and monkeys. Cogn Affect Behav Neurosci. 2023 06; 23(3):600-619. Woo JH, Aguirre CG, Bari BA, Tsutsui KI, Grabenhorst F, Cohen JY, Schultz W, Izquierdo A, Soltani A. PMID: 36823249; PMCID: PMC10444905.

View in: PubMed Mentions: Fields:
Beh Behavioral Sciences Neu Neurology
Translation:Animals
A hardware system for real-time decoding of in vivo calcium imaging data. Elife. 2023 01 24; 12. Chen Z, Blair GJ, Guo C, Zhou J, Romero-Sosa JL, Izquierdo A, Golshani P, Cong J, Aharoni D, Blair HT. PMID: 36692269; PMCID: PMC9908073.

View in: PubMed Mentions: 2 Fields:
Bio Biology
Translation:Animals
Timing, neural timescales, and temporal cognition. Behav Neurosci. 2022 Oct; 136(5):347-348. Sanabria F, Langdon A, Izquierdo A. PMID: 36222636.

View in: PubMed Mentions: Fields:
Beh Behavioral Sciences Neu Neurology
Introducing Oxford Open Neuroscience. Oxf Open Neurosci. 2022; 1:kvac005. Gilbert S, Ibáñez C, Izquierdo A, Reiner O, Wang H. PMID: 38596703; PMCID: PMC10913827.

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Translational opportunities in animal and human models to study alcohol use disorder. Transl Psychiatry. 2021 09 29; 11(1):496. Nieto SJ, Grodin EN, Aguirre CG, Izquierdo A, Ray LA. PMID: 34588417; PMCID: PMC8481537.

View in: PubMed Mentions: 20 Fields:
Psy Psychiatry
Translation:Humans Animals
Foraging with the frontal cortex: A cross-species evaluation of reward-guided behavior. Neuropsychopharmacology. 2022 01; 47(1):134-146. Rudebeck PH, Izquierdo A. PMID: 34408279; PMCID: PMC8617092.

View in: PubMed Mentions: 18 Fields:
Neu Neurology Psy Psychopharmacology
Translation:Animals
Unique features of stimulus-based probabilistic reversal learning. Behav Neurosci. 2021 Aug; 135(4):550-570. Harris C, Aguirre C, Kolli S, Das K, Izquierdo A, Soltani A. PMID: 34460275; PMCID: PMC9205533.

View in: PubMed Mentions: 14 Fields:
Beh Behavioral Sciences Neu Neurology
Translation:Animals
The orbitofrontal cortex in temporal cognition. Behav Neurosci. 2021 Apr; 135(2):154-164. Sosa JLR, Buonomano D, Izquierdo A. PMID: 34060872; PMCID: PMC8171116.

View in: PubMed Mentions: 12 Fields:
Beh Behavioral Sciences Neu Neurology
Translation:Humans
Touchscreen response technology and the power of stimulus-based approaches in freely behaving animals. Genes Brain Behav. 2021 01; 20(1):e12720. Izquierdo A. PMID: 33295087; PMCID: PMC8015966.

View in: PubMed Mentions: Fields:
Beh Behavioral Sciences Bra Brain Gen Genetics
Translation:Animals
Sex-dependent effects of chronic intermittent voluntary alcohol consumption on attentional, not motivational, measures during probabilistic learning and reversal. PLoS One. 2020; 15(6):e0234729. Aguirre CG, Stolyarova A, Das K, Kolli S, Marty V, Ray L, Spigelman I, Izquierdo A. PMID: 32555668; PMCID: PMC7302450.

View in: PubMed Mentions: 11 Fields:
Med Medicine (General)Sci Science
Translation:Animals
Chemogenetic Modulation and Single-Photon Calcium Imaging in Anterior Cingulate Cortex Reveal a Mechanism for Effort-Based Decisions. J Neurosci. 2020 07 15; 40(29):5628-5643. Hart EE, Blair GJ, O'Dell TJ, Blair HT, Izquierdo A. PMID: 32527984; PMCID: PMC7363467.

View in: PubMed Mentions: 25 Fields:
Neu Neurology
Translation:Animals Cells
Adaptive learning under expected and unexpected uncertainty. Nat Rev Neurosci. 2019 10; 20(10):635-644. Soltani A, Izquierdo A. PMID: 31147631; PMCID: PMC6752962.

View in: PubMed Mentions: 90 Fields:
Neu Neurology
Translation:Humans Animals
Quantity versus quality: Convergent findings in effort-based choice tasks. Behav Processes. 2019 Jul; 164:178-185. Hart EE, Izquierdo A. PMID: 31082477; PMCID: PMC6557689.

View in: PubMed Mentions: 5 Fields:
Beh Behavioral Sciences
Translation:Animals
Rodent Models of Adaptive Value Learning and Decision-Making. Methods Mol Biol. 2019; 2011:105-119. Izquierdo A, Aguirre C, Hart EE, Stolyarova A. PMID: 31273696.

View in: PubMed Mentions: 6 Fields:
Mol Molecular Biology
Translation:Animals
Persistent effect of withdrawal from intravenous methamphetamine self-administration on brain activation and behavioral economic indices involving an effort cost. Neuropharmacology. 2018 09 15; 140:130-138. Hart EE, Gerson JO, Izquierdo A. PMID: 30053443; PMCID: PMC6442736.

View in: PubMed Mentions: 12 Fields:
Neu Neurology Pha Pharmacology
Translation:Animals
Functional Heterogeneity within Rat Orbitofrontal Cortex in Reward Learning and Decision Making. J Neurosci. 2017 11 01; 37(44):10529-10540. Izquierdo A. PMID: 29093055; PMCID: PMC6596524.

View in: PubMed Mentions: 128 Fields:
Neu Neurology
Translation:Animals
Complementary contributions of basolateral amygdala and orbitofrontal cortex to value learning under uncertainty. Elife. 2017 07 06; 6. Stolyarova A, Izquierdo A. PMID: 28682238; PMCID: PMC5533586.

View in: PubMed Mentions: 24 Fields:
Bio Biology
Translation:Animals
Anterior cingulate cortex supports effort allocation towards a qualitatively preferred option. Eur J Neurosci. 2017 Jul; 46(1):1682-1688. Hart EE, Gerson JO, Zoken Y, Garcia M, Izquierdo A. PMID: 28543944; PMCID: PMC6442740.

View in: PubMed Mentions: 16 Translation:Animals
Steep effort discounting of a preferred reward over a freely-available option in prolonged methamphetamine withdrawal in male rats. Psychopharmacology (Berl). 2017 Sep; 234(18):2697-2705. Thompson AB, Gerson J, Stolyarova A, Bugarin A, Hart EE, Jentsch JD, Izquierdo A. PMID: 28584929; PMCID: PMC6441328.

View in: PubMed Mentions: 9 Fields:
Psy Psychopharmacology
Translation:Animals
Basolateral amygdala supports the maintenance of value and effortful choice of a preferred option. Eur J Neurosci. 2017 02; 45(3):388-397. Hart EE, Izquierdo A. PMID: 27977047.

View in: PubMed Mentions: 11 Translation:Animals
Rigid patterns of effortful choice behavior after acute stress in rats. Stress. 2017 01; 20(1):19-28. Hart EE, Stolyarova A, Conoscenti MA, Minor TR, Izquierdo A. PMID: 27820975.

View in: PubMed Mentions: 2 Fields:
Neu Neurology
Translation:Animals
Sex differences, learning flexibility, and striatal dopamine D1 and D2 following adolescent drug exposure in rats. Behav Brain Res. 2016 07 15; 308:104-14. Izquierdo A, Pozos H, Torre Ade L, DeShields S, Cevallos J, Rodriguez J, Stolyarova A. PMID: 27091300; PMCID: PMC4946635.

View in: PubMed Mentions: 13 Fields:
Beh Behavioral Sciences Bra Brain
Translation:Animals
The neural basis of reversal learning: An updated perspective. Neuroscience. 2017 03 14; 345:12-26. Izquierdo A, Brigman JL, Radke AK, Rudebeck PH, Holmes A. PMID: 26979052; PMCID: PMC5018909.

View in: PubMed Mentions: 253 Fields:
Neu Neurology
Translation:Humans Animals Cells
Hijacking translation in addiction. Elife. 2016 Mar 01; 5. Izquierdo A, Silva AJ. PMID: 26929992; PMCID: PMC4786444.

View in: PubMed Mentions: Fields:
Bio Biology
Translation:Humans
The basolateral amygdala in reward learning and addiction. Neurosci Biobehav Rev. 2015 Oct; 57:271-83. Wassum KM, Izquierdo A. PMID: 26341938; PMCID: PMC4681295.

View in: PubMed Mentions: 144 Fields:
Beh Behavioral Sciences Neu Neurology
Translation:Humans Animals
Methamphetamine blocks exercise effects on Bdnf and Drd2 gene expression in frontal cortex and striatum. Neuropharmacology. 2015 Dec; 99:658-64. Thompson AB, Stolyarova A, Ying Z, Zhuang Y, Gómez-Pinilla F, Izquierdo A. PMID: 26334786; PMCID: PMC5352165.

View in: PubMed Mentions: 11 Fields:
Neu Neurology Pha Pharmacology
Translation:Animals Cells
Post-training depletions of basolateral amygdala serotonin fail to disrupt discrimination, retention, or reversal learning. Front Neurosci. 2015; 9:155. Ochoa JG, Stolyarova A, Kaur A, Hart EE, Bugarin A, Izquierdo A. PMID: 26029036; PMCID: PMC4426727.

View in: PubMed Mentions: 4
Distinct patterns of outcome valuation and amygdala-prefrontal cortex synaptic remodeling in adolescence and adulthood. Front Behav Neurosci. 2015; 9:115. Stolyarova A, Izquierdo A. PMID: 25999830; PMCID: PMC4423437.

View in: PubMed Mentions: 10
Reductions in frontocortical cytokine levels are associated with long-lasting alterations in reward valuation after methamphetamine. Neuropsychopharmacology. 2015 Mar 13; 40(5):1234-42. Stolyarova A, Thompson AB, Barrientos RM, Izquierdo A. PMID: 25409594; PMCID: PMC4367468.

View in: PubMed Mentions: 13 Fields:
Neu Neurology Psy Psychopharmacology
Translation:Animals
Positive and negative feedback learning and associated dopamine and serotonin transporter binding after methamphetamine. Behav Brain Res. 2014 Sep 01; 271:195-202. Stolyarova A, O'Dell SJ, Marshall JF, Izquierdo A. PMID: 24959862; PMCID: PMC4232208.

View in: PubMed Mentions: 15 Fields:
Beh Behavioral Sciences Bra Brain
Translation:Animals
Long-term effects of exposure to methamphetamine in adolescent rats. Drug Alcohol Depend. 2014 May 01; 138:17-23. Ye T, Pozos H, Phillips TJ, Izquierdo A. PMID: 24629630; PMCID: PMC4066881.

View in: PubMed Mentions: 11 Fields:
Sub Substance-Related Disorders
Translation:Animals
Basolateral amygdala lesions facilitate reward choices after negative feedback in rats. J Neurosci. 2013 Feb 27; 33(9):4105-9. Izquierdo A, Darling C, Manos N, Pozos H, Kim C, Ostrander S, Cazares V, Stepp H, Rudebeck PH. PMID: 23447618; PMCID: PMC3606920.

View in: PubMed Mentions: 37 Fields:
Neu Neurology
Translation:Animals
Comparison of single-dose and extended methamphetamine administration on reversal learning in rats. Psychopharmacology (Berl). 2012 Dec; 224(3):459-67. Kosheleff AR, Rodriguez D, O'Dell SJ, Marshall JF, Izquierdo A. PMID: 22760483; PMCID: PMC6441327.

View in: PubMed Mentions: 19 Fields:
Psy Psychopharmacology
Translation:Animals
Impaired reward learning and intact motivation after serotonin depletion in rats. Behav Brain Res. 2012 Aug 01; 233(2):494-9. Izquierdo A, Carlos K, Ostrander S, Rodriguez D, McCall-Craddolph A, Yagnik G, Zhou F. PMID: 22652392; PMCID: PMC3402622.

View in: PubMed Mentions: 29 Fields:
Beh Behavioral Sciences Bra Brain
Translation:Animals
Rodent models of adaptive decision making. Methods Mol Biol. 2012; 829:85-101. Izquierdo A, Belcher AM. PMID: 22231808; PMCID: PMC6501796.

View in: PubMed Mentions: 12 Fields:
Mol Molecular Biology
Translation:Animals
Reversal learning as a measure of impulsive and compulsive behavior in addictions. Psychopharmacology (Berl). 2012 Jan; 219(2):607-20. Izquierdo A, Jentsch JD. PMID: 22134477; PMCID: PMC3249486.

View in: PubMed Mentions: 158 Fields:
Psy Psychopharmacology
Translation:Humans
Do GluA1 knockout mice exhibit behavioral abnormalities relevant to the negative or cognitive symptoms of schizophrenia and schizoaffective disorder? Neuropharmacology. 2012 Mar; 62(3):1263-72. Barkus C, Feyder M, Graybeal C, Wright T, Wiedholz L, Izquierdo A, Kiselycznyk C, Schmitt W, Sanderson DJ, Rawlins JN, Saksida LM, Bussey TJ, Sprengel R, Bannerman D, Holmes A. PMID: 21693126; PMCID: PMC3208051.

View in: PubMed Mentions: 49 Fields:
Neu Neurology Pha Pharmacology
Translation:Animals
Work aversion and associated changes in dopamine and serotonin transporter after methamphetamine exposure in rats. Psychopharmacology (Berl). 2012 Jan; 219(2):411-20. Kosheleff AR, Grimes M, O'Dell SJ, Marshall JF, Izquierdo A. PMID: 21643674; PMCID: PMC3182297.

View in: PubMed Mentions: 12 Fields:
Psy Psychopharmacology
Translation:Animals
Orbitofrontal cortex and basolateral amygdala lesions result in suboptimal and dissociable reward choices on cue-guided effort in rats. Behav Neurosci. 2011 Jun; 125(3):350-9. Ostrander S, Cazares VA, Kim C, Cheung S, Gonzalez I, Izquierdo A. PMID: 21639604; PMCID: PMC3111944.

View in: PubMed Mentions: 21 Fields:
Beh Behavioral Sciences Neu Neurology
Translation:Animals
Functional interaction of medial mediodorsal thalamic nucleus but not nucleus accumbens with amygdala and orbital prefrontal cortex is essential for adaptive response selection after reinforcer devaluation. J Neurosci. 2010 Jan 13; 30(2):661-9. Izquierdo A, Murray EA. PMID: 20071531; PMCID: PMC2835504.

View in: PubMed Mentions: 46 Fields:
Neu Neurology
Translation:Animals
Reversal-specific learning impairments after a binge regimen of methamphetamine in rats: possible involvement of striatal dopamine. Neuropsychopharmacology. 2010 Jan; 35(2):505-14. Izquierdo A, Belcher AM, Scott L, Cazares VA, Chen J, O'Dell SJ, Malvaez M, Wu T, Marshall JF. PMID: 19794407; PMCID: PMC2795129.

View in: PubMed Mentions: 57 Fields:
Neu Neurology Psy Psychopharmacology
Translation:Animals Cells
Pharmacological or genetic inactivation of the serotonin transporter improves reversal learning in mice. Cereb Cortex. 2010 Aug; 20(8):1955-63. Brigman JL, Mathur P, Harvey-White J, Izquierdo A, Saksida LM, Bussey TJ, Fox S, Deneris E, Murphy DL, Holmes A. PMID: 20032063; PMCID: PMC2912649.

View in: PubMed Mentions: 98 Fields:
Bra Brain
Translation:Animals Cells
Distinct contributions of the amygdala and hippocampus to fear expression. Eur J Neurosci. 2009 Dec; 30(12):2327-37. Chudasama Y, Izquierdo A, Murray EA. PMID: 20092575; PMCID: PMC2852103.

View in: PubMed Mentions: 46 Translation:Animals
Orbitofrontal cortex and amygdala contributions to affect and action in primates. Ann N Y Acad Sci. 2007 Dec; 1121:273-96. Murray EA, Izquierdo A. PMID: 17846154.

View in: PubMed Mentions: 67 Fields:
Sci Science
Translation:Humans Animals
Genetic modulation of cognitive flexibility and socioemotional behavior in rhesus monkeys. Proc Natl Acad Sci U S A. 2007 Aug 28; 104(35):14128-33. Izquierdo A, Newman TK, Higley JD, Murray EA. PMID: 17715054; PMCID: PMC1950559.

View in: PubMed Mentions: 35 Fields:
Sci Science
Translation:Humans Animals
Selective bilateral amygdala lesions in rhesus monkeys fail to disrupt object reversal learning. J Neurosci. 2007 Jan 31; 27(5):1054-62. Izquierdo A, Murray EA. PMID: 17267559; PMCID: PMC6673199.

View in: PubMed Mentions: 76 Fields:
Neu Neurology
Translation:Animals
Brief uncontrollable stress causes dendritic retraction in infralimbic cortex and resistance to fear extinction in mice. J Neurosci. 2006 May 24; 26(21):5733-8. Izquierdo A, Wellman CL, Holmes A. PMID: 16723530; PMCID: PMC6675270.

View in: PubMed Mentions: 234 Fields:
Neu Neurology
Translation:Animals Cells
Genetic and dopaminergic modulation of reversal learning in a touchscreen-based operant procedure for mice. Behav Brain Res. 2006 Aug 10; 171(2):181-8. Izquierdo A, Wiedholz LM, Millstein RA, Yang RJ, Bussey TJ, Saksida LM, Holmes A. PMID: 16713639.

View in: PubMed Mentions: 69 Fields:
Beh Behavioral Sciences Bra Brain
Translation:Animals
Opposing effects of amygdala and orbital prefrontal cortex lesions on the extinction of instrumental responding in macaque monkeys. Eur J Neurosci. 2005 Nov; 22(9):2341-6. Izquierdo A, Murray EA. PMID: 16262672.

View in: PubMed Mentions: 48 Translation:Animals
Comparison of the effects of bilateral orbital prefrontal cortex lesions and amygdala lesions on emotional responses in rhesus monkeys. J Neurosci. 2005 Sep 14; 25(37):8534-42. Izquierdo A, Suda RK, Murray EA. PMID: 16162935; PMCID: PMC6725674.

View in: PubMed Mentions: 96 Fields:
Neu Neurology
Translation:Animals
Bilateral orbital prefrontal cortex lesions in rhesus monkeys disrupt choices guided by both reward value and reward contingency. J Neurosci. 2004 Aug 25; 24(34):7540-8. Izquierdo A, Suda RK, Murray EA. PMID: 15329401; PMCID: PMC6729636.

View in: PubMed Mentions: 316 Fields:
Neu Neurology
Translation:Animals
Combined unilateral lesions of the amygdala and orbital prefrontal cortex impair affective processing in rhesus monkeys. J Neurophysiol. 2004 May; 91(5):2023-39. Izquierdo A, Murray EA. PMID: 14711973.

View in: PubMed Mentions: 87 Fields:
Neu Neurology Phy Physiology
Translation:Animals