Dean Buonomano

Title(s)Professor, Neurobiology
SchoolMedicine
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    CRCNS: Multiple clocks for the encoding of time in corticostriatal circuits
    NIH R01NS125877Sep 23, 2021 - Aug 31, 2026
    Role: Co-Principal Investigator
    Multiplexing working memory and timing: Encoding retrospective and prospective information in transient neural trajectories.
    NIH R01NS116589Apr 15, 2020 - Mar 31, 2023
    Role: Principal Investigator
    CRCNS: Network mechanisms of the learning and encoding of timed motor responses
    NIH R01NS100050Jul 1, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Abnormal network dynamics and learning in neural circuits from Fmr1-/- mice
    NIH R21MH097093Sep 19, 2012 - Aug 31, 2015
    Role: Principal Investigator
    Learning temporal patterns: computational and experimental studies of timing
    NIH R03NS077340Jul 1, 2012 - Jun 30, 2014
    Role: Principal Investigator
    Computations and Unsupervised Learning in Recurrent Neural Networks
    NIH R03MH076888Jul 3, 2007 - Jun 30, 2010
    Role: Principal Investigator
    TIMING AND LEARNING IN IN VITRO CORTICAL NETWORKS
    NIH R01MH060163Sep 22, 2001 - Aug 31, 2020
    Role: Principal Investigator
    CORTICAL CONDITIONING OF SOMATOTOPIC RECEPTIVE FIELDS
    NIH F32MH010431Jun 23, 1993
    Role: Principal Investigator
    LONG-TERM ASSOCIATIVE NEURAL PLASTICITY IN APLYSIA
    NIH F31MH009895Mar 12, 1990
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Neural population clocks: Encoding time in dynamic patterns of neural activity. Behav Neurosci. 2022 Apr 21. Zhou S, Buonomano DV. PMID: 35446093.
      View in: PubMed   Mentions:
    2. Encoding time in neural dynamic regimes with distinct computational tradeoffs. PLoS Comput Biol. 2022 03; 18(3):e1009271. Zhou S, Masmanidis SC, Buonomano DV. PMID: 35239644; PMCID: PMC8893702.
      View in: PubMed   Mentions:
    3. Differential Excitability of PV and SST Neurons Results in Distinct Functional Roles in Inhibition Stabilization of Up States. J Neurosci. 2021 08 25; 41(34):7182-7196. Romero-Sosa JL, Motanis H, Buonomano DV. PMID: 34253625; PMCID: PMC8387123.
      View in: PubMed   Mentions:    Fields:    
    4. The orbitofrontal cortex in temporal cognition. Behav Neurosci. 2021 Apr; 135(2):154-164. Sosa JLR, Buonomano D, Izquierdo A. PMID: 34060872; PMCID: PMC8171116.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Differential Short-Term Plasticity of PV and SST Neurons Accounts for Adaptation and Facilitation of Cortical Neurons to Auditory Tones. J Neurosci. 2020 11 25; 40(48):9224-9235. Seay MJ, Natan RG, Geffen MN, Buonomano DV. PMID: 33097639; PMCID: PMC7687067.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    6. Neural Sequences as an Optimal Dynamical Regime for the Readout of Time. Neuron. 2020 11 25; 108(4):651-658.e5. Zhou S, Masmanidis SC, Buonomano DV. PMID: 32946745; PMCID: PMC7825362.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    7. Decreased reproducibility and abnormal experience-dependent plasticity of network dynamics in Fragile X circuits. Sci Rep. 2020 09 03; 10(1):14535. Motanis H, Buonomano D. PMID: 32884028; PMCID: PMC7471942.
      View in: PubMed   Mentions:
    8. Musical expertise generalizes to superior temporal scaling in a Morse code tapping task. PLoS One. 2020; 15(1):e0221000. Slayton MA, Romero-Sosa JL, Shore K, Buonomano DV, Viskontas IV. PMID: 31905200; PMCID: PMC6944339.
      View in: PubMed   Mentions:
    9. A model of temporal scaling correctly predicts that motor timing improves with speed. Nat Commun. 2018 11 09; 9(1):4732. Hardy NF, Goudar V, Romero-Sosa JL, Buonomano DV. PMID: 30413692; PMCID: PMC6226482.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    10. Short-Term Synaptic Plasticity as a Mechanism for Sensory Timing. Trends Neurosci. 2018 10; 41(10):701-711. Motanis H, Seay MJ, Buonomano DV. PMID: 30274605; PMCID: PMC6171349.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    11. The Neural Basis of Timing: Distributed Mechanisms for Diverse Functions. Neuron. 2018 05 16; 98(4):687-705. Paton JJ, Buonomano DV. PMID: 29772201; PMCID: PMC5962026.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    12. Encoding sensory and motor patterns as time-invariant trajectories in recurrent neural networks. Elife. 2018 03 14; 7. Goudar V, Buonomano DV. PMID: 29537963; PMCID: PMC5851701.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    13. Encoding Time in Feedforward Trajectories of a Recurrent Neural Network Model. Neural Comput. 2018 02; 30(2):378-396. Hardy NF, Buonomano DV. PMID: 29162002; PMCID: PMC5873300.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    14. Differential Encoding of Time by Prefrontal and Striatal Network Dynamics. J Neurosci. 2017 01 25; 37(4):854-870. Bakhurin KI, Goudar V, Shobe JL, Claar LD, Buonomano DV, Masmanidis SC. PMID: 28123021; PMCID: PMC5296780.
      View in: PubMed   Mentions: 36     Fields:    Translation:Animals
    15. Temporal Interval Learning in Cortical Cultures Is Encoded in Intrinsic Network Dynamics. Neuron. 2016 07 20; 91(2):320-7. Goel A, Buonomano DV. PMID: 27346530; PMCID: PMC4969202.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    16. Neurocomputational Models of Interval and Pattern Timing. Curr Opin Behav Sci. 2016 Apr; 8:250-257. Hardy NF, Buonomano DV. PMID: 27790629; PMCID: PMC5077164.
      View in: PubMed   Mentions: 10  
    17. Time in Cortical Circuits. J Neurosci. 2015 Oct 14; 35(41):13912-6. Finnerty GT, Shadlen MN, Jazayeri M, Nobre AC, Buonomano DV. PMID: 26468192; PMCID: PMC4604229.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    18. Delayed in vitro development of Up states but normal network plasticity in Fragile X circuits. Eur J Neurosci. 2015 Sep; 42(6):2312-21. Motanis H, Buonomano D. PMID: 26138886; PMCID: PMC5873292.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    19. Neural coding: time contraction and dilation in the striatum. Curr Biol. 2015 May 04; 25(9):R374-6. Motanis H, Buonomano DV. PMID: 25942552.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    20. Multifocal fluorescence microscope for fast optical recordings of neuronal action potentials. Biophys J. 2015 Feb 03; 108(3):520-9. Shtrahman M, Aharoni DB, Hardy NF, Buonomano DV, Arisaka K, Otis TS. PMID: 25650920; PMCID: PMC4317551.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    21. A model of order-selectivity based on dynamic changes in the balance of excitation and inhibition produced by short-term synaptic plasticity. J Neurophysiol. 2015 Jan 15; 113(2):509-23. Goudar V, Buonomano DV. PMID: 25339707; PMCID: PMC4297794.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    22. Useful dynamic regimes emerge in recurrent networks. Nat Neurosci. 2014 Apr; 17(4):487-9. Goudar V, Buonomano DV. PMID: 24671063.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    23. Timing as an intrinsic property of neural networks: evidence from in vivo and in vitro experiments. Philos Trans R Soc Lond B Biol Sci. 2014 Mar 05; 369(1637):20120460. Goel A, Buonomano DV. PMID: 24446494; PMCID: PMC3895985.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    24. Neural dynamics based timing in the subsecond to seconds range. Adv Exp Med Biol. 2014; 829:101-17. Buonomano DV. PMID: 25358707.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    25. Neuroscience: Brain projects need stronger foundation. Nature. 2013 Sep 05; 501(7465):33. Buonomano D. PMID: 24005405.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. Robust timing and motor patterns by taming chaos in recurrent neural networks. Nat Neurosci. 2013 Jul; 16(7):925-33. Laje R, Buonomano DV. PMID: 23708144; PMCID: PMC3753043.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansAnimalsCells
    27. Chronic electrical stimulation homeostatically decreases spontaneous activity, but paradoxically increases evoked network activity. J Neurophysiol. 2013 Apr; 109(7):1824-36. Goel A, Buonomano DV. PMID: 23324317; PMCID: PMC3628006.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    28. Unsupervised formation of vocalization-sensitive neurons: a cortical model based on short-term and homeostatic plasticity. Neural Comput. 2012 Oct; 24(10):2579-603. Lee TP, Buonomano DV. PMID: 22845822.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    29. Developmental shift of short-term synaptic plasticity in cortical organotypic slices. Neuroscience. 2012 Jun 28; 213:38-46. Chen WX, Buonomano DV. PMID: 22521823; PMCID: PMC3367122.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    30. Learning of temporal motor patterns: an analysis of continuous versus reset timing. Front Integr Neurosci. 2011; 5:61. Laje R, Cheng K, Buonomano DV. PMID: 22016724; PMCID: PMC3192320.
      View in: PubMed   Mentions: 9  
    31. A novel learning rule for long-term plasticity of short-term synaptic plasticity enhances temporal processing. Front Integr Neurosci. 2011; 5:20. Carvalho TP, Buonomano DV. PMID: 21660100; PMCID: PMC3105243.
      View in: PubMed   Mentions: 17  
    32. Population clocks: motor timing with neural dynamics. Trends Cogn Sci. 2010 Dec; 14(12):520-7. Buonomano DV, Laje R. PMID: 20889368; PMCID: PMC2991437.
      View in: PubMed   Mentions: 56     Fields:    Translation:Humans
    33. Neural dynamics of in vitro cortical networks reflects experienced temporal patterns. Nat Neurosci. 2010 Aug; 13(8):917-9. Johnson HA, Goel A, Buonomano DV. PMID: 20543842; PMCID: PMC2910842.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    34. Embedding multiple trajectories in simulated recurrent neural networks in a self-organizing manner. J Neurosci. 2009 Oct 21; 29(42):13172-81. Liu JK, Buonomano DV. PMID: 19846705; PMCID: PMC6665184.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    35. Harnessing chaos in recurrent neural networks. Neuron. 2009 Aug 27; 63(4):423-5. Buonomano DV. PMID: 19709625; PMCID: PMC5466426.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    36. Influence of the interstimulus interval on temporal processing and learning: testing the state-dependent network model. Philos Trans R Soc Lond B Biol Sci. 2009 Jul 12; 364(1525):1865-73. Buonomano DV, Bramen J, Khodadadifar M. PMID: 19487189; PMCID: PMC2685819.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    37. Differential effects of excitatory and inhibitory plasticity on synaptically driven neuronal input-output functions. Neuron. 2009 Mar 12; 61(5):774-85. Carvalho TP, Buonomano DV. PMID: 19285473; PMCID: PMC2676350.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    38. State-dependent computations: spatiotemporal processing in cortical networks. Nat Rev Neurosci. 2009 Feb; 10(2):113-25. Buonomano DV, Maass W. PMID: 19145235.
      View in: PubMed   Mentions: 268     Fields:    Translation:HumansAnimals
    39. A method for chronic stimulation of cortical organotypic cultures using implanted electrodes. J Neurosci Methods. 2009 Jan 30; 176(2):136-43. Johnson HA, Buonomano DV. PMID: 18835297.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    40. Distortions of subjective time perception within and across senses. PLoS One. 2008 Jan 16; 3(1):e1437. van Wassenhove V, Buonomano DV, Shimojo S, Shams L. PMID: 18197248; PMCID: PMC2174530.
      View in: PubMed   Mentions: 55     Fields:    Translation:Humans
    41. The biology of time across different scales. Nat Chem Biol. 2007 Oct; 3(10):594-7. Buonomano DV. PMID: 17876310.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    42. Development and plasticity of spontaneous activity and Up states in cortical organotypic slices. J Neurosci. 2007 May 30; 27(22):5915-25. Johnson HA, Buonomano DV. PMID: 17537962; PMCID: PMC6672255.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    43. Timing in the absence of clocks: encoding time in neural network states. Neuron. 2007 Feb 01; 53(3):427-38. Karmarkar UR, Buonomano DV. PMID: 17270738; PMCID: PMC1857310.
      View in: PubMed   Mentions: 164     Fields:    Translation:Humans
    44. Different forms of homeostatic plasticity are engaged with distinct temporal profiles. Eur J Neurosci. 2006 Mar; 23(6):1575-84. Karmarkar UR, Buonomano DV. PMID: 16553621.
      View in: PubMed   Mentions: 48     Fields:    Translation:Animals
    45. Time and the brain: how subjective time relates to neural time. J Neurosci. 2005 Nov 09; 25(45):10369-71. Eagleman DM, Tse PU, Buonomano D, Janssen P, Nobre AC, Holcombe AO. PMID: 16280574; PMCID: PMC6725822.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimals
    46. A learning rule for the emergence of stable dynamics and timing in recurrent networks. J Neurophysiol. 2005 Oct; 94(4):2275-83. Buonomano DV. PMID: 16160088.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    47. A technique for repeated recordings in cortical organotypic slices. J Neurosci Methods. 2005 Jul 15; 146(1):69-75. Dong HW, Buonomano DV. PMID: 15935222.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    48. Timing and balance of inhibition enhance the effect of long-term potentiation on cell firing. J Neurosci. 2004 Oct 06; 24(40):8873-84. Marder CP, Buonomano DV. PMID: 15470154; PMCID: PMC6729972.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    49. The neural basis of temporal processing. Annu Rev Neurosci. 2004; 27:307-40. Mauk MD, Buonomano DV. PMID: 15217335.
      View in: PubMed   Mentions: 285     Fields:    Translation:HumansAnimals
    50. Timing of neural responses in cortical organotypic slices. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4897-902. Buonomano DV. PMID: 12668762; PMCID: PMC153652.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    51. Temporal specificity of perceptual learning in an auditory discrimination task. Learn Mem. 2003 Mar-Apr; 10(2):141-7. Karmarkar UR, Buonomano DV. PMID: 12663752; PMCID: PMC196662.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    52. Differential effects of short- and long-term potentiation on cell firing in the CA1 region of the hippocampus. J Neurosci. 2003 Jan 01; 23(1):112-21. Marder CP, Buonomano DV. PMID: 12514207; PMCID: PMC6742129.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    53. Mechanisms and significance of spike-timing dependent plasticity. Biol Cybern. 2002 Dec; 87(5-6):373-82. Karmarkar UR, Najarian MT, Buonomano DV. PMID: 12461627.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    54. A model of spike-timing dependent plasticity: one or two coincidence detectors? J Neurophysiol. 2002 Jul; 88(1):507-13. Karmarkar UR, Buonomano DV. PMID: 12091572.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimals
    55. How do we tell time? Neuroscientist. 2002 Feb; 8(1):42-51. Buonomano DV, Karmarkar UR. PMID: 11843098.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimals
    56. Decoding temporal information: A model based on short-term synaptic plasticity. J Neurosci. 2000 Feb 01; 20(3):1129-41. Buonomano DV. PMID: 10648718; PMCID: PMC6774169.
      View in: PubMed   Mentions: 83     Fields:    Translation:Cells
    57. Distinct functional types of associative long-term potentiation in neocortical and hippocampal pyramidal neurons. J Neurosci. 1999 Aug 15; 19(16):6748-54. Buonomano DV. PMID: 10436032; PMCID: PMC6782844.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    58. A neural network model of temporal code generation and position-invariant pattern recognition. Neural Comput. 1999 Jan 01; 11(1):103-16. Buonomano DV, Merzenich M. PMID: 9950725.
      View in: PubMed   Mentions: 7     Fields:    
    59. Net interaction between different forms of short-term synaptic plasticity and slow-IPSPs in the hippocampus and auditory cortex. J Neurophysiol. 1998 Oct; 80(4):1765-74. Buonomano DV, Merzenich MM. PMID: 9772237.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    60. Cortical plasticity: from synapses to maps. Annu Rev Neurosci. 1998; 21:149-86. Buonomano DV, Merzenich MM. PMID: 9530495.
      View in: PubMed   Mentions: 469     Fields:    Translation:AnimalsCells
    61. Context-sensitive synaptic plasticity and temporal-to-spatial transformations in hippocampal slices. Proc Natl Acad Sci U S A. 1997 Sep 16; 94(19):10403-8. Buonomano DV, Hickmott PW, Merzenich MM. PMID: 9294223; PMCID: PMC23375.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    62. Learning and generalization of auditory temporal-interval discrimination in humans. J Neurosci. 1997 May 15; 17(10):3956-63. Wright BA, Buonomano DV, Mahncke HW, Merzenich MM. PMID: 9133413; PMCID: PMC6573705.
      View in: PubMed   Mentions: 79     Fields:    Translation:Humans
    63. Associative synaptic plasticity in hippocampal CA1 neurons is not sensitive to unpaired presynaptic activity. J Neurophysiol. 1996 Jul; 76(1):631-6. Buonomano DV, Merzenich MM. PMID: 8836251.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    64. Temporal information transformed into a spatial code by a neural network with realistic properties. Science. 1995 Feb 17; 267(5200):1028-30. Buonomano DV, Merzenich MM. PMID: 7863330.
      View in: PubMed   Mentions: 111     Fields:    Translation:Cells
    65. Inhibitory neuron produces heterosynaptic inhibition of the sensory-to-motor neuron synapse in Aplysia. Brain Res. 1992 Apr 10; 577(1):147-50. Buonomano DV, Cleary LJ, Byrne JH. PMID: 1521140.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    66. Neural and molecular bases of nonassociative and associative learning in Aplysia. Ann N Y Acad Sci. 1991; 627:124-49. Byrne JH, Baxter DA, Buonomano DV, Cleary LJ, Eskin A, Goldsmith JR, McClendon E, Nazif FA, Noel F, Scholz KP. PMID: 1679307.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    67. Long-term synaptic changes produced by a cellular analog of classical conditioning in Aplysia. Science. 1990 Jul 27; 249(4967):420-3. Buonomano DV, Byrne JH. PMID: 2165631.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    68. Neuronal and network determinants of simple and higher-order features of associative learning: experimental and modeling approaches. Cold Spring Harb Symp Quant Biol. 1990; 55:175-86. Byrne JH, Baxter DA, Buonomano DV, Raymond JL. PMID: 1983443.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
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