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Khakh, Baljit S

Title(s)Professor, Physiology
Phone56258, 57185
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    Other Positions
    Title(s)Professor, Neurobiology


    Collapse Research 
    Collapse Research Activities and Funding
    Fundamental astrocyte biology in intact neural circuits
    NIH/NINDS R35NS111583May 1, 2019 - Apr 30, 2027
    Role: Principal Investigator
    New tools to target, identify and characterize astrocytes in the adult nervous system
    NIH/NIDA R01DA047444Sep 15, 2018 - Jun 30, 2021
    Role: Principal Investigator
    A genetically-encoded sensor for imaging extracellular ATP onto astrocytes and other cells
    NIH/NINDS R21NS100525Sep 30, 2016 - Aug 31, 2018
    Role: Principal Investigator
    Building and sharing next generation open-source, wireless, multichannel miniaturized microscopes for imaging activity in freely behaving mice
    NIH/NINDS U01NS094286Sep 30, 2015 - Jun 30, 2018
    Role: Co-Principal Investigator
    Astrocyte branchlet dysfunction as an early step in brain disorders
    NIH/NIMH DP1MH104069Sep 26, 2013 - Aug 31, 2018
    Role: Principal Investigator
    New Optical and Genetic Tools to Study Diverse Calcium Signals in Astrocytes
    NIH/NIMH R01MH099559Jan 15, 2013 - Oct 31, 2017
    Role: Principal Investigator
    Optical reporter mice to study P2X4 receptors in microglia
    NIH/NINDS R21NS073980Jun 1, 2011 - May 31, 2014
    Role: Principal Investigator
    An approach to image calcium in small volumes of astrocytes in vivo
    NIH/NINDS R21NS071292Jul 1, 2010 - Jun 30, 2012
    Role: Principal Investigator
    Tracking transmitter gated P2X cation channel activation in vitro and in vivo.
    NIH/NINDS R21NS063186Jul 1, 2008 - Apr 30, 2011
    Role: Principal Investigator
    Functions of astrocyte calcium signaling in the striatum
    NIH/NINDS R01NS060677Dec 1, 2007 - May 31, 2022
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Badia-Soteras A, Octeau JC, Verheijen MHG, Khakh BS. Assessing Neuron-Astrocyte Spatial Interactions Using the Neuron-Astrocyte Proximity Assay. Curr Protoc Neurosci. 2020 Mar; 91(1):e91. PMID: 32068967.
      View in: PubMed
    2. Yu X, Nagai J, Khakh BS. Improved tools to study astrocytes. Nat Rev Neurosci. 2020 Mar; 21(3):121-138. PMID: 32042146.
      View in: PubMed
    3. Shuman T, Aharoni D, Cai DJ, Lee CR, Chavlis S, Page-Harley L, Vetere LM, Feng Y, Yang CY, Mollinedo-Gajate I, Chen L, Pennington ZT, Taxidis J, Flores SE, Cheng K, Javaherian M, Kaba CC, Rao N, La-Vu M, Pandi I, Shtrahman M, Bakhurin KI, Masmanidis SC, Khakh BS, Poirazi P, Silva AJ, Golshani P. Breakdown of spatial coding and interneuron synchronization in epileptic mice. Nat Neurosci. 2020 Feb; 23(2):229-238. PMID: 31907437.
      View in: PubMed
    4. Diaz-Castro B, Gangwani MR, Yu X, Coppola G, Khakh BS. Astrocyte molecular signatures in Huntington's disease. Sci Transl Med. 2019 Oct 16; 11(514). PMID: 31619545.
      View in: PubMed
    5. Moye SL, Diaz-Castro B, Gangwani MR, Khakh BS. Visualizing Astrocyte Morphology Using Lucifer Yellow Iontophoresis. J Vis Exp. 2019 Sep 14; (151). PMID: 31566622.
      View in: PubMed
    6. Khakh BS. Astrocyte-Neuron Interactions in the Striatum: Insights on Identity, Form, and Function. Trends Neurosci. 2019 Sep; 42(9):617-630. PMID: 31351745.
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    7. Khakh BS, Deneen B. The Emerging Nature of Astrocyte Diversity. Annu Rev Neurosci. 2019 07 08; 42:187-207. PMID: 31283899.
      View in: PubMed
    8. Octeau JC, Gangwani MR, Allam SL, Tran D, Huang S, Hoang-Trong TM, Golshani P, Rumbell TH, Kozloski JR, Khakh BS. Transient, Consequential Increases in Extracellular Potassium Ions Accompany Channelrhodopsin2 Excitation. Cell Rep. 2019 05 21; 27(8):2249-2261.e7. PMID: 31116972.
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    9. Nagai J, Rajbhandari AK, Gangwani MR, Hachisuka A, Coppola G, Masmanidis SC, Fanselow MS, Khakh BS. Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue. Cell. 2019 05 16; 177(5):1280-1292.e20. PMID: 31031006.
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    10. Lobas MA, Tao R, Nagai J, Kronschläger MT, Borden PM, Marvin JS, Looger LL, Khakh BS. A genetically encoded single-wavelength sensor for imaging cytosolic and cell surface ATP. Nat Commun. 2019 02 12; 10(1):711. PMID: 30755613.
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    11. Giovannucci A, Friedrich J, Gunn P, Kalfon J, Brown BL, Koay SA, Taxidis J, Najafi F, Gauthier JL, Zhou P, Khakh BS, Tank DW, Chklovskii DB, Pnevmatikakis EA. CaImAn an open source tool for scalable calcium imaging data analysis. Elife. 2019 01 17; 8. PMID: 30652683.
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    12. Aharoni D, Khakh BS, Silva AJ, Golshani P. All the light that we can see: a new era in miniaturized microscopy. Nat Methods. 2019 Jan; 16(1):11-13. PMID: 30573833.
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    13. Yu X, Taylor AMW, Nagai J, Golshani P, Evans CJ, Coppola G, Khakh BS. Reducing Astrocyte Calcium Signaling In Vivo Alters Striatal Microcircuits and Causes Repetitive Behavior. Neuron. 2018 09 19; 99(6):1170-1187.e9. PMID: 30174118.
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    14. Khennouf L, Gesslein B, Brazhe A, Octeau JC, Kutuzov N, Khakh BS, Lauritzen M. Active role of capillary pericytes during stimulation-induced activity and spreading depolarization. Brain. 2018 07 01; 141(7):2032-2046. PMID: 30053174.
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    15. Octeau JC, Faas G, Mody I, Khakh BS. Making, Testing, and Using Potassium Ion Selective Microelectrodes in Tissue Slices of Adult Brain. J Vis Exp. 2018 05 07; (135). PMID: 29781998.
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    16. Octeau JC, Chai H, Jiang R, Bonanno SL, Martin KC, Khakh BS. An Optical Neuron-Astrocyte Proximity Assay at Synaptic Distance Scales. Neuron. 2018 04 04; 98(1):49-66.e9. PMID: 29621490.
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    17. Watanabe M, Buth JE, Vishlaghi N, de la Torre-Ubieta L, Taxidis J, Khakh BS, Coppola G, Pearson CA, Yamauchi K, Gong D, Dai X, Damoiseaux R, Aliyari R, Liebscher S, Schenke-Layland K, Caneda C, Huang EJ, Zhang Y, Cheng G, Geschwind DH, Golshani P, Sun R, Novitch BG. Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection. Cell Rep. 2017 Oct 10; 21(2):517-532. PMID: 29020636.
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    18. Chai H, Diaz-Castro B, Shigetomi E, Monte E, Octeau JC, Yu X, Cohn W, Rajendran PS, Vondriska TM, Whitelegge JP, Coppola G, Khakh BS. Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence. Neuron. 2017 Aug 02; 95(3):531-549.e9. PMID: 28712653.
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    19. Khakh BS, Beaumont V, Cachope R, Munoz-Sanjuan I, Goldman SA, Grantyn R. Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease. Trends Neurosci. 2017 07; 40(7):422-437. PMID: 28578789.
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    20. Srinivasan R, Lu TY, Chai H, Xu J, Huang BS, Golshani P, Coppola G, Khakh BS. New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In Vivo. Neuron. 2016 Dec 21; 92(6):1181-1195. PMID: 27939582.
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    21. Xu J, Bernstein AM, Wong A, Lu XH, Khoja S, Yang XW, Davies DL, Micevych P, Sofroniew MV, Khakh BS. P2X4 Receptor Reporter Mice: Sparse Brain Expression and Feeding-Related Presynaptic Facilitation in the Arcuate Nucleus. J Neurosci. 2016 08 24; 36(34):8902-20. PMID: 27559172.
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    22. Anderson MA, Burda JE, Ren Y, Ao Y, O'Shea TM, Kawaguchi R, Coppola G, Khakh BS, Deming TJ, Sofroniew MV. Astrocyte scar formation aids central nervous system axon regeneration. Nature. 2016 Apr 14; 532(7598):195-200. PMID: 27027288.
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    23. Jiang R, Diaz-Castro B, Looger LL, Khakh BS. Dysfunctional Calcium and Glutamate Signaling in Striatal Astrocytes from Huntington's Disease Model Mice. J Neurosci. 2016 Mar 23; 36(12):3453-70. PMID: 27013675.
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    24. Akassoglou K, Agalliu D, Chang CJ, Davalos D, Grutzendler J, Hillman EM, Khakh BS, Kleinfeld D, McGavern DB, Nelson SJ, Zlokovic BV. Neurovascular and Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium. Front Neurosci. 2016; 10:46. PMID: 26941593.
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    25. Shigetomi E, Patel S, Khakh BS. Probing the Complexities of Astrocyte Calcium Signaling. Trends Cell Biol. 2016 Apr; 26(4):300-312. PMID: 26896246.
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    26. Olsen ML, Khakh BS, Skatchkov SN, Zhou M, Lee CJ, Rouach N. New Insights on Astrocyte Ion Channels: Critical for Homeostasis and Neuron-Glia Signaling. J Neurosci. 2015 Oct 14; 35(41):13827-35. PMID: 26468182.
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    27. Khakh BS, Sofroniew MV. Diversity of astrocyte functions and phenotypes in neural circuits. Nat Neurosci. 2015 Jul; 18(7):942-52. PMID: 26108722.
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    28. Srinivasan R, Huang BS, Venugopal S, Johnston AD, Chai H, Zeng H, Golshani P, Khakh BS. Ca(2+) signaling in astrocytes from Ip3r2(-/-) mice in brain slices and during startle responses in vivo. Nat Neurosci. 2015 May; 18(5):708-17. PMID: 25894291.
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    29. Khakh BS, McCarthy KD. Astrocyte calcium signaling: from observations to functions and the challenges therein. Cold Spring Harb Perspect Biol. 2015 Jan 20; 7(4):a020404. PMID: 25605709.
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    30. Jiang R, Haustein MD, Sofroniew MV, Khakh BS. Imaging intracellular Ca²? signals in striatal astrocytes from adult mice using genetically-encoded calcium indicators. J Vis Exp. 2014 Nov 19; (93):e51972. PMID: 25490346.
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    31. Burnstock G, Nistri A, Khakh BS, Giniatullin R. ATP-gated P2X receptors in health and disease. Front Cell Neurosci. 2014; 8:204. PMID: 25104924.
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    32. Xu J, Khakh BS. Slow neuromodulation mediated by ATP P2X receptors. Neuron. 2014 Jul 16; 83(2):257-259. PMID: 25033174.
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    33. Xu J, Chai H, Ehinger K, Egan TM, Srinivasan R, Frick M, Khakh BS. Imaging P2X4 receptor subcellular distribution, trafficking, and regulation using P2X4-pHluorin. J Gen Physiol. 2014 Jul; 144(1):81-104. PMID: 24935743.
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    34. Khakh BS, Sofroniew MV. Astrocytes and Huntington's disease. ACS Chem Neurosci. 2014 Jul 16; 5(7):494-6. PMID: 24842291.
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    35. Haustein MD, Kracun S, Lu XH, Shih T, Jackson-Weaver O, Tong X, Xu J, Yang XW, O'Dell TJ, Marvin JS, Ellisman MH, Bushong EA, Looger LL, Khakh BS. Conditions and constraints for astrocyte calcium signaling in the hippocampal mossy fiber pathway. Neuron. 2014 Apr 16; 82(2):413-29. PMID: 24742463.
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    36. Gray EE, Guglietta R, Khakh BS, O'Dell TJ. Inhibitory interactions between phosphorylation sites in the C terminus of a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunits. J Biol Chem. 2014 May 23; 289(21):14600-11. PMID: 24706758.
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    37. Tong X, Ao Y, Faas GC, Nwaobi SE, Xu J, Haustein MD, Anderson MA, Mody I, Olsen ML, Sofroniew MV, Khakh BS. Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice. Nat Neurosci. 2014 May; 17(5):694-703. PMID: 24686787.
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    38. Zhang S, Anderson MA, Ao Y, Khakh BS, Fan J, Deming TJ, Sofroniew MV. Tunable diblock copolypeptide hydrogel depots for local delivery of hydrophobic molecules in healthy and injured central nervous system. Biomaterials. 2014 Feb; 35(6):1989-2000. PMID: 24314556.
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    39. Shigetomi E, Jackson-Weaver O, Huckstepp RT, O'Dell TJ, Khakh BS. TRPA1 channels are regulators of astrocyte basal calcium levels and long-term potentiation via constitutive D-serine release. J Neurosci. 2013 Jun 12; 33(24):10143-53. PMID: 23761909.
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    40. Housley GD, Morton-Jones R, Vlajkovic SM, Telang RS, Paramananthasivam V, Tadros SF, Wong AC, Froud KE, Cederholm JM, Sivakumaran Y, Snguanwongchai P, Khakh BS, Cockayne DA, Thorne PR, Ryan AF. ATP-gated ion channels mediate adaptation to elevated sound levels. Proc Natl Acad Sci U S A. 2013 Apr 30; 110(18):7494-9. PMID: 23592720.
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    41. Shigetomi E, Bushong EA, Haustein MD, Tong X, Jackson-Weaver O, Kracun S, Xu J, Sofroniew MV, Ellisman MH, Khakh BS. Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses. J Gen Physiol. 2013 May; 141(5):633-47. PMID: 23589582.
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    42. Tong X, Shigetomi E, Looger LL, Khakh BS. Genetically encoded calcium indicators and astrocyte calcium microdomains. Neuroscientist. 2013 Jun; 19(3):274-91. PMID: 23264008.
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    43. Hamby ME, Coppola G, Ao Y, Geschwind DH, Khakh BS, Sofroniew MV. Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors. J Neurosci. 2012 Oct 17; 32(42):14489-510. PMID: 23077035.
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    44. Khakh BS, North RA. Neuromodulation by extracellular ATP and P2X receptors in the CNS. Neuron. 2012 Oct 04; 76(1):51-69. PMID: 23040806.
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    45. Akerboom J, Chen TW, Wardill TJ, Tian L, Marvin JS, Mutlu S, Calderón NC, Esposti F, Borghuis BG, Sun XR, Gordus A, Orger MB, Portugues R, Engert F, Macklin JJ, Filosa A, Aggarwal A, Kerr RA, Takagi R, Kracun S, Shigetomi E, Khakh BS, Baier H, Lagnado L, Wang SS, Bargmann CI, Kimmel BE, Jayaraman V, Svoboda K, Kim DS, Schreiter ER, Looger LL. Optimization of a GCaMP calcium indicator for neural activity imaging. J Neurosci. 2012 Oct 03; 32(40):13819-40. PMID: 23035093.
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    46. Toulme E, Khakh BS. Imaging P2X4 receptor lateral mobility in microglia: regulation by calcium and p38 MAPK. J Biol Chem. 2012 Apr 27; 287(18):14734-48. PMID: 22393055.
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    47. Samways DS, Khakh BS, Egan TM. Allosteric modulation of Ca2+ flux in ligand-gated cation channel (P2X4) by actions on lateral portals. J Biol Chem. 2012 Mar 02; 287(10):7594-602. PMID: 22219189.
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    48. Shigetomi E, Tong X, Kwan KY, Corey DP, Khakh BS. TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3. Nat Neurosci. 2011 Dec 11; 15(1):70-80. PMID: 22158513.
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    49. Richler E, Shigetomi E, Khakh BS. Neuronal P2X2 receptors are mobile ATP sensors that explore the plasma membrane when activated. J Neurosci. 2011 Nov 16; 31(46):16716-30. PMID: 22090499.
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    50. Samways DS, Khakh BS, Dutertre S, Egan TM. Preferential use of unobstructed lateral portals as the access route to the pore of human ATP-gated ion channels (P2X receptors). Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13800-5. PMID: 21808018.
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    51. Reeves AM, Shigetomi E, Khakh BS. Bulk loading of calcium indicator dyes to study astrocyte physiology: key limitations and improvements using morphological maps. J Neurosci. 2011 Jun 22; 31(25):9353-8. PMID: 21697385.
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    52. Shigetomi E, Kracun S, Khakh BS. Monitoring astrocyte calcium microdomains with improved membrane targeted GCaMP reporters. Neuron Glia Biol. 2010 Aug; 6(3):183-91. PMID: 21205365.
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    53. Shigetomi E, Kracun S, Sofroniew MV, Khakh BS. A genetically targeted optical sensor to monitor calcium signals in astrocyte processes. Nat Neurosci. 2010 Jun; 13(6):759-66. PMID: 20495558.
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    54. Toulme E, Garcia A, Samways D, Egan TM, Carson MJ, Khakh BS. P2X4 receptors in activated C8-B4 cells of cerebellar microglial origin. J Gen Physiol. 2010 Apr; 135(4):333-53. PMID: 20231374.
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    55. Kracun S, Chaptal V, Abramson J, Khakh BS. Gated access to the pore of a P2X receptor: structural implications for closed-open transitions. J Biol Chem. 2010 Mar 26; 285(13):10110-21. PMID: 20093367.
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    56. Khakh BS, Burnstock G. The double life of ATP. Sci Am. 2009 Dec; 301(6):84-90, 92. PMID: 20058644.
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    57. Singh H, Warburton S, Vondriska TM, Khakh BS. Proteomics to identify proteins interacting with P2X2 ligand-gated cation channels. J Vis Exp. 2009 May 18; (27). PMID: 19455095.
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    58. Shigetomi E, Khakh BS. Measuring near plasma membrane and global intracellular calcium dynamics in astrocytes. J Vis Exp. 2009 Apr 26; (26). PMID: 19396060.
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    59. Chaumont S, Compan V, Toulme E, Richler E, Housley GD, Rassendren F, Khakh BS. Regulation of P2X2 receptors by the neuronal calcium sensor VILIP1. Sci Signal. 2008 Oct 14; 1(41):ra8. PMID: 18922787.
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    60. Samways DS, Khakh BS, Egan TM. Tunable calcium current through TRPV1 receptor channels. J Biol Chem. 2008 Nov 14; 283(46):31274-8. PMID: 18775990.
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    61. Chaumont S, Khakh BS. Patch-clamp coordinated spectroscopy shows P2X2 receptor permeability dynamics require cytosolic domain rearrangements but not Panx-1 channels. Proc Natl Acad Sci U S A. 2008 Aug 19; 105(33):12063-8. PMID: 18689682.
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    62. Young MT, Fisher JA, Fountain SJ, Ford RC, North RA, Khakh BS. Molecular shape, architecture, and size of P2X4 receptors determined using fluorescence resonance energy transfer and electron microscopy. J Biol Chem. 2008 Sep 19; 283(38):26241-51. PMID: 18635539.
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    63. Jarvis MF, Khakh BS. ATP-gated P2X cation-channels. Neuropharmacology. 2009 Jan; 56(1):208-15. PMID: 18657557.
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    64. Shigetomi E, Bowser DN, Sofroniew MV, Khakh BS. Two forms of astrocyte calcium excitability have distinct effects on NMDA receptor-mediated slow inward currents in pyramidal neurons. J Neurosci. 2008 Jun 25; 28(26):6659-63. PMID: 18579739.
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    65. Khakh BS. ATP-gated P2X receptors on excitatory nerve terminals onto interneurons initiate a form of asynchronous glutamate release. Neuropharmacology. 2009 Jan; 56(1):216-22. PMID: 18601937.
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    66. Richler E, Chaumont S, Shigetomi E, Sagasti A, Khakh BS. Tracking transmitter-gated P2X cation channel activation in vitro and in vivo. Nat Methods. 2008 Jan; 5(1):87-93. PMID: 18084300.
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    67. Bowser DN, Khakh BS. Vesicular ATP is the predominant cause of intercellular calcium waves in astrocytes. J Gen Physiol. 2007 Jun; 129(6):485-91. PMID: 17504911.
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    68. Bowser DN, Khakh BS. Two forms of single-vesicle astrocyte exocytosis imaged with total internal reflection fluorescence microscopy. Proc Natl Acad Sci U S A. 2007 Mar 06; 104(10):4212-7. PMID: 17360502.
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    69. Khakh BS, North RA. P2X receptors as cell-surface ATP sensors in health and disease. Nature. 2006 Aug 03; 442(7102):527-32. PMID: 16885977.
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    70. Khakh BS, Fisher JA, Nashmi R, Bowser DN, Lester HA. An angstrom scale interaction between plasma membrane ATP-gated P2X2 and alpha4beta2 nicotinic channels measured with fluorescence resonance energy transfer and total internal reflection fluorescence microscopy. J Neurosci. 2005 Jul 20; 25(29):6911-20. PMID: 16033901.
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    71. Khakh BS, Egan TM. Contribution of transmembrane regions to ATP-gated P2X2 channel permeability dynamics. J Biol Chem. 2005 Feb 18; 280(7):6118-29. PMID: 15556949.
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    72. Fisher JA, Girdler G, Khakh BS. Time-resolved measurement of state-specific P2X2 ion channel cytosolic gating motions. J Neurosci. 2004 Nov 17; 24(46):10475-87. PMID: 15548662.
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    73. Bowser DN, Khakh BS. ATP excites interneurons and astrocytes to increase synaptic inhibition in neuronal networks. J Neurosci. 2004 Sep 29; 24(39):8606-20. PMID: 15456834.
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    74. Egan TM, Khakh BS. Contribution of calcium ions to P2X channel responses. J Neurosci. 2004 Mar 31; 24(13):3413-20. PMID: 15056721.
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    75. Girdler G, Khakh BS. ATP-gated P2X channels. Curr Biol. 2004 Jan 06; 14(1):R6. PMID: 14711422.
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    76. Khakh BS, Gittermann D, Cockayne DA, Jones A. ATP modulation of excitatory synapses onto interneurons. J Neurosci. 2003 Aug 13; 23(19):7426-37. PMID: 12917379.
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    77. Eickhorst AN, Berson A, Cockayne D, Lester HA, Khakh BS. Control of P2X(2) channel permeability by the cytosolic domain. J Gen Physiol. 2002 Aug; 120(2):119-31. PMID: 12149275.
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    78. Khakh BS, Smith WB, Chiu CS, Ju D, Davidson N, Lester HA. Activation-dependent changes in receptor distribution and dendritic morphology in hippocampal neurons expressing P2X2-green fluorescent protein receptors. Proc Natl Acad Sci U S A. 2001 Apr 24; 98(9):5288-93. PMID: 11296257.
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    79. Khakh BS. Molecular physiology of P2X receptors and ATP signalling at synapses. Nat Rev Neurosci. 2001 Mar; 2(3):165-74. PMID: 11256077.
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    80. Khakh BS, Burnstock G, Kennedy C, King BF, North RA, Séguéla P, Voigt M, Humphrey PP. International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits. Pharmacol Rev. 2001 Mar; 53(1):107-18. PMID: 11171941.
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    81. Labarca C, Schwarz J, Deshpande P, Schwarz S, Nowak MW, Fonck C, Nashmi R, Kofuji P, Dang H, Shi W, Fidan M, Khakh BS, Chen Z, Bowers BJ, Boulter J, Wehner JM, Lester HA. Point mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety. Proc Natl Acad Sci U S A. 2001 Feb 27; 98(5):2786-91. PMID: 11226318.
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    82. Patel MK, Khakh BS, Henderson G. Properties of native P2X receptors in rat trigeminal mesencephalic nucleus neurones: lack of correlation with known, heterologously expressed P2X receptors. Neuropharmacology. 2001; 40(1):96-105. PMID: 11077075.
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    83. Khakh BS, Zhou X, Sydes J, Galligan JJ, Lester HA. State-dependent cross-inhibition between transmitter-gated cation channels. Nature. 2000 Jul 27; 406(6794):405-10. PMID: 10935636.
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    84. Khakh BS, Henderson G. Modulation of fast synaptic transmission by presynaptic ligand-gated cation channels. J Auton Nerv Syst. 2000 Jul 03; 81(1-3):110-21. PMID: 10869709.
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    85. Khakh BS, Proctor WR, Dunwiddie TV, Labarca C, Lester HA. Allosteric control of gating and kinetics at P2X(4) receptor channels. J Neurosci. 1999 Sep 01; 19(17):7289-99. PMID: 10460235.
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    86. Khakh BS, Lester HA. Dynamic selectivity filters in ion channels. Neuron. 1999 Aug; 23(4):653-8. PMID: 10482233.
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    87. Khakh BS, Bao XR, Labarca C, Lester HA. Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds. Nat Neurosci. 1999 Apr; 2(4):322-30. PMID: 10204538.
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    88. Khakh BS, Henderson G. ATP receptor-mediated enhancement of fast excitatory neurotransmitter release in the brain. Mol Pharmacol. 1998 Aug; 54(2):372-8. PMID: 9687579.
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    89. Khakh BS, Henderson G. Hyperpolarization-activated cationic currents (Ih) in neurones of the trigeminal mesencephalic nucleus of the rat. J Physiol. 1998 Aug 01; 510 ( Pt 3):695-704. PMID: 9660886.
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    90. Khakh BS, Kennedy C. Adenosine and ATP: progress in their receptors' structures and functions. Trends Pharmacol Sci. 1998 Feb; 19(2):39-41. PMID: 9550938.
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    91. Khakh BS, Humphrey PP, Henderson G. ATP-gated cation channels (P2X purinoceptors) in trigeminal mesencephalic nucleus neurons of the rat. J Physiol. 1997 Feb 01; 498 ( Pt 3):709-15. PMID: 9051582.
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    92. Humphrey PP, Buell G, Kennedy I, Khakh BS, Michel AD, Surprenant A, Trezise DJ. New insights on P2X purinoceptors. Naunyn Schmiedebergs Arch Pharmacol. 1995 Dec; 352(6):585-96. PMID: 9053729.
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    93. Trezise DJ, Michel AD, Grahames CB, Khakh BS, Surprenant A, Humphrey PP. The selective P2X purinoceptor agonist, beta,gamma-methylene-L-adenosine 5'-triphosphate, discriminates between smooth muscle and neuronal P2X purinoceptors. Naunyn Schmiedebergs Arch Pharmacol. 1995 Jun; 351(6):603-9. PMID: 7675118.
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    94. Khakh BS, Surprenant A, Humphrey PP. A study on P2X purinoceptors mediating the electrophysiological and contractile effects of purine nucleotides in rat vas deferens. Br J Pharmacol. 1995 May; 115(1):177-85. PMID: 7647973.
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