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Bennett G Novitch

Title(s)Professor, Neurobiology
SchoolMedicine
Address760 Westwood Plaza 73-210
Los Angeles CA 90024
Phone49339
ORCID ORCID Icon0000-0002-2696-3708 Additional info
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    Collapse Research 
    Collapse Research Activities and Funding
    Integrative Modeling of HIV-Associated Neurocognitive Disorder in Human Brain Organoids
    NIH/NIDA R01DA051897Aug 1, 2020 - May 31, 2025
    Role: Principal Investigator
    Notch-mediated modulation of Sonic hedgehog signaling in neural fate specification and differentiation
    NIH/NINDS R21NS115012Aug 1, 2020 - Jul 31, 2022
    Role: Principal Investigator
    Regulation of neural progenitor functions underlying cortical growth & complexity
    NIH/NINDS R01NS089817Sep 15, 2015 - May 31, 2020
    Role: Principal Investigator
    Molecular Pathways Controlling Respiratory Motor Neuron Formation and Function
    NIH/NINDS R01NS085227May 15, 2015 - Apr 30, 2020
    Role: Principal Investigator
    Transcriptional regulation of neuronal differentiation
    NIH/NINDS R01NS072804Sep 1, 2010 - Aug 31, 2015
    Role: Principal Investigator
    Function of Olig2-Regulated Genes in Spinal Motor Neuron Development
    NIH/NINDS R01NS053976Jan 15, 2006 - Dec 31, 2011
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Foxp1 Regulates Neural Stem Cell Self-Renewal and Bias Toward Deep Layer Cortical Fates. Cell Rep. 2020 Feb 11; 30(6):1964-1981.e3. Pearson CA, Moore DM, Tucker HO, Dekker JD, Hu H, Miquelajáuregui A, Novitch BG. PMID: 32049024.
      View in: PubMed   Mentions: 1     Fields:    
    2. New perspectives on the mechanisms establishing the dorsal-ventral axis of the spinal cord. Curr Top Dev Biol. 2019; 132:417-450. Andrews MG, Kong J, Novitch BG, Butler SJ. PMID: 30797516.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics. PLoS Biol. 2018 02; 16(2):e2003127. Sagner A, Gaber ZB, Delile J, Kong JH, Rousso DL, Pearson CA, Weicksel SE, Melchionda M, Mousavy Gharavy SN, Briscoe J, Novitch BG. PMID: 29389974.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    4. Molecular specification of facial branchial motor neurons in vertebrates. Dev Biol. 2018 04 01; 436(1):5-13. Han AY, Gupta S, Novitch BG. PMID: 29391164.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection. Cell Rep. 2017 Oct 10; 21(2):517-532. Watanabe M, Buth JE, Vishlaghi N, de la Torre-Ubieta L, Taxidis J, Khakh BS, Coppola G, Pearson CA, Yamauchi K, Gong D, Dai X, Damoiseaux R, Aliyari R, Liebscher S, Schenke-Layland K, Caneda C, Huang EJ, Zhang Y, Cheng G, Geschwind DH, Golshani P, Sun R, Novitch BG. PMID: 29020636.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    6. Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS). Proc Natl Acad Sci U S A. 2017 08 15; 114(33):8770-8775. Sangwan S, Zhao A, Adams KL, Jayson CK, Sawaya MR, Guenther EL, Pan AC, Ngo J, Moore DM, Soriaga AB, Do TD, Goldschmidt L, Nelson R, Bowers MT, Koehler CM, Shaw DE, Novitch BG, Eisenberg DS. PMID: 28760994.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    7. Netrin1 Produced by Neural Progenitors, Not Floor Plate Cells, Is Required for Axon Guidance in the Spinal Cord. Neuron. 2017 May 17; 94(4):790-799.e3. Varadarajan SG, Kong JH, Phan KD, Kao TJ, Panaitof SC, Cardin J, Eltzschig H, Kania A, Novitch BG, Butler SJ. PMID: 28434801.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    8. 25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model. Immunity. 2017 03 21; 46(3):446-456. Li C, Deng YQ, Wang S, Ma F, Aliyari R, Huang XY, Zhang NN, Watanabe M, Dong HL, Liu P, Li XF, Ye Q, Tian M, Hong S, Fan J, Zhao H, Li L, Vishlaghi N, Buth JE, Au C, Liu Y, Lu N, Du P, Qin FX, Zhang B, Gong D, Dai X, Sun R, Novitch BG, Xu Z, Qin CF, Cheng G. PMID: 28314593.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    9. Cbx3 maintains lineage specificity during neural differentiation. Genes Dev. 2017 02 01; 31(3):241-246. Huang C, Su T, Xue Y, Cheng C, Lay FD, McKee RA, Li M, Vashisht A, Wohlschlegel J, Novitch BG, Plath K, Kurdistani SK, Carey M. PMID: 28270516.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    10. The splicing regulator PTBP1 controls the activity of the transcription factor Pbx1 during neuronal differentiation. Elife. 2015 Dec 24; 4:e09268. Linares AJ, Lin CH, Damianov A, Adams KL, Novitch BG, Black DL. PMID: 26705333.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    11. Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling. Dev Cell. 2015 May 26; 33(4):373-87. Kong JH, Yang L, Dessaud E, Chuang K, Moore DM, Rohatgi R, Briscoe J, Novitch BG. PMID: 25936505.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    12. Foxp1-mediated programming of limb-innervating motor neurons from mouse and human embryonic stem cells. Nat Commun. 2015 Apr 14; 6:6778. Adams KL, Rousso DL, Umbach JA, Novitch BG. PMID: 25868900.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    13. Neuronal organization: unsticking the cadherin code. Curr Biol. 2014 Dec 01; 24(23):R1127-9. Pearson CA, Butler SJ, Novitch BG. PMID: 25465332.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    14. Gli protein activity is controlled by multisite phosphorylation in vertebrate Hedgehog signaling. Cell Rep. 2014 Jan 16; 6(1):168-181. Niewiadomski P, Kong JH, Ahrends R, Ma Y, Humke EW, Khan S, Teruel MN, Novitch BG, Rohatgi R. PMID: 24373970.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    15. Hox5 interacts with Plzf to restrict Shh expression in the developing forelimb. Proc Natl Acad Sci U S A. 2013 Nov 26; 110(48):19438-43. Xu B, Hrycaj SM, McIntyre DC, Baker NC, Takeuchi JK, Jeannotte L, Gaber ZB, Novitch BG, Wellik DM. PMID: 24218595.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    16. PLZF regulates fibroblast growth factor responsiveness and maintenance of neural progenitors. PLoS Biol. 2013 Oct; 11(10):e1001676. Gaber ZB, Butler SJ, Novitch BG. PMID: 24115909.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    17. My brain told me to do it. Dev Cell. 2013 Jun 10; 25(5):436-8. Kong JH, Butler SJ, Novitch BG. PMID: 23763945.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    18. Retinoid acid specifies neuronal identity through graded expression of Ascl1. Curr Biol. 2013 Mar 04; 23(5):412-8. Jacob J, Kong J, Moore S, Milton C, Sasai N, Gonzalez-Quevedo R, Terriente J, Imayoshi I, Kageyama R, Kageyama R, Wilkinson DG, Novitch BG, Briscoe J. PMID: 23416099.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    19. ERK inhibition rescues defects in fate specification of Nf1-deficient neural progenitors and brain abnormalities. Cell. 2012 Aug 17; 150(4):816-30. Wang Y, Kim E, Wang X, Novitch BG, Yoshikawa K, Chang LS, Zhu Y. PMID: 22901811.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    20. Onecut transcription factors act upstream of Isl1 to regulate spinal motoneuron diversification. Development. 2012 Sep; 139(17):3109-19. Roy A, Francius C, Rousso DL, Seuntjens E, Debruyn J, Luxenhofer G, Huber AB, Huylebroeck D, Novitch BG, Clotman F. PMID: 22833130.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    21. Functional neuromuscular junctions formed by embryonic stem cell-derived motor neurons. PLoS One. 2012; 7(5):e36049. Umbach JA, Adams KL, Gundersen CB, Novitch BG. PMID: 22574134.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    22. Foxp-mediated suppression of N-cadherin regulates neuroepithelial character and progenitor maintenance in the CNS. Neuron. 2012 Apr 26; 74(2):314-30. Rousso DL, Pearson CA, Gaber ZB, Miquelajauregui A, Li S, Portera-Cailliau C, Morrisey EE, Novitch BG. PMID: 22542185.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    23. Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Neuron. 2012 Apr 12; 74(1):79-94. Kang P, Lee HK, Glasgow SM, Finley M, Donti T, Gaber ZB, Graham BH, Foster AE, Novitch BG, Gronostajski RM, Deneen B. PMID: 22500632.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    24. Regulation of spinal interneuron development by the Olig-related protein Bhlhb5 and Notch signaling. Development. 2011 Aug; 138(15):3199-211. Skaggs K, Martin DM, Novitch BG. PMID: 21750031.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    25. All the embryo's a stage, and Olig2 in its time plays many parts. Neuron. 2011 Mar 10; 69(5):833-5. Gaber ZB, Novitch BG. PMID: 21382543.
      View in: PubMed   Mentions: 6     Fields:    
    26. Npn-1 contributes to axon-axon interactions that differentially control sensory and motor innervation of the limb. PLoS Biol. 2011 Feb; 9(2):e1001020. Huettl RE, Soellner H, Bianchi E, Novitch BG, Huber AB. PMID: 21364975.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    27. Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling. PLoS Biol. 2010 Aug 10; 8(8):e1000446. Palmesino E, Rousso DL, Kao TJ, Klar A, Laufer E, Uemura O, Okamoto H, Novitch BG, Kania A. PMID: 20711475.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    28. Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube. Genes Dev. 2010 Jun 01; 24(11):1186-200. Ribes V, Balaskas N, Sasai N, Cruz C, Dessaud E, Cayuso J, Tozer S, Yang LL, Novitch B, Marti E, Briscoe J. PMID: 20516201.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    29. Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog. PLoS Biol. 2010 Jun 01; 8(6):e1000382. Dessaud E, Ribes V, Balaskas N, Yang LL, Pierani A, Kicheva A, Novitch BG, Briscoe J, Sasai N. PMID: 20532235.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    30. Reducing the mystery of neuronal differentiation. Cell. 2009 Sep 18; 138(6):1062-4. Novitch BG, Butler SJ. PMID: 19766560.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    31. Sonic hedgehog signaling controls thalamic progenitor identity and nuclei specification in mice. J Neurosci. 2009 Apr 08; 29(14):4484-97. Vue TY, Bluske K, Alishahi A, Yang LL, Koyano-Nakagawa N, Novitch B, Nakagawa Y. PMID: 19357274.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    32. Directed differentiation of human-induced pluripotent stem cells generates active motor neurons. Stem Cells. 2009 Apr; 27(4):806-11. Karumbayaram S, Novitch BG, Patterson M, Umbach JA, Richter L, Lindgren A, Conway AE, Clark AT, Goldman SA, Plath K, Wiedau-Pazos M, Kornblum HI, Lowry WE. PMID: 19350680.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansCells
    33. Coordinated actions of the forkhead protein Foxp1 and Hox proteins in the columnar organization of spinal motor neurons. Neuron. 2008 Jul 31; 59(2):226-40. Rousso DL, Gaber ZB, Wellik D, Morrisey EE, Novitch BG. PMID: 18667151.
      View in: PubMed   Mentions: 109     Fields:    Translation:AnimalsCells
    34. Regulatory pathways linking progenitor patterning, cell fates and neurogenesis in the ventral neural tube. Philos Trans R Soc Lond B Biol Sci. 2008 Jan 12; 363(1489):57-70. Briscoe J, Novitch BG. PMID: 17282991.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    35. Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism. Nature. 2007 Nov 29; 450(7170):717-20. Dessaud E, Yang LL, Hill K, Cox B, Ulloa F, Ribeiro A, Mynett A, Novitch BG, Briscoe J. PMID: 18046410.
      View in: PubMed   Mentions: 185     Fields:    Translation:AnimalsCells
    36. Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo. Proc Natl Acad Sci U S A. 2006 Jan 31; 103(5):1551-6. Mukouyama YS, Deneen B, Lukaszewicz A, Novitch BG, Wichterle H, Jessell TM, Anderson DJ. PMID: 16432183.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    37. Olig2 directs astrocyte and oligodendrocyte formation in postnatal subventricular zone cells. J Neurosci. 2005 Aug 10; 25(32):7289-98. Marshall CA, Novitch BG, Goldman JE. PMID: 16093378.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    38. PAK4 kinase is essential for embryonic viability and for proper neuronal development. Mol Cell Biol. 2003 Oct; 23(20):7122-33. Qu J, Li X, Novitch BG, Zheng Y, Kohn M, Xie JM, Kozinn S, Bronson R, Beg AA, Minden A. PMID: 14517283.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    39. Vertebrate neurogenesis is counteracted by Sox1-3 activity. Nat Neurosci. 2003 Nov; 6(11):1162-8. Bylund M, Andersson E, Novitch BG, Muhr J. PMID: 14517545.
      View in: PubMed   Mentions: 266     Fields:    Translation:AnimalsCells
    40. A requirement for retinoic acid-mediated transcriptional activation in ventral neural patterning and motor neuron specification. Neuron. 2003 Sep 25; 40(1):81-95. Novitch BG, Wichterle H, Jessell TM, Sockanathan S. PMID: 14527435.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansAnimalsCells
    41. Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2. Neuron. 2001 Sep 13; 31(5):773-89. Novitch BG, Chen AI, Jessell TM. PMID: 11567616.
      View in: PubMed   Mentions: 180     Fields:    Translation:AnimalsCells
    42. pRb is required for MEF2-dependent gene expression as well as cell-cycle arrest during skeletal muscle differentiation. Curr Biol. 1999 May 06; 9(9):449-59. Novitch BG, Spicer DB, Kim PS, Cheung WL, Lassar AB. PMID: 10322110.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    43. Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth. Genes Dev. 1998 Jan 01; 12(1):95-106. Sellers WR, Novitch BG, Miyake S, Heith A, Otterson GA, Kaye FJ, Lassar AB, Kaelin WG. PMID: 9420334.
      View in: PubMed   Mentions: 129     Fields:    Translation:HumansCells
    44. Cyclin-mediated inhibition of muscle gene expression via a mechanism that is independent of pRB hyperphosphorylation. Mol Cell Biol. 1996 Dec; 16(12):7043-53. Skapek SX, Rhee J, Kim PS, Novitch BG, Lassar AB. PMID: 8943359.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    45. Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle. J Cell Biol. 1996 Oct; 135(2):441-56. Novitch BG, Mulligan GJ, Jacks T, Lassar AB. PMID: 8896600.
      View in: PubMed   Mentions: 105     Fields:    Translation:AnimalsCells
    46. Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science. 1995 Feb 17; 267(5200):1018-21. Halevy O, Novitch BG, Spicer DB, Skapek SX, Rhee J, Hannon GJ, Beach D, Lassar AB. PMID: 7863327.
      View in: PubMed   Mentions: 310     Fields:    Translation:HumansAnimalsCells
    47. Regulatory mechanisms that coordinate skeletal muscle differentiation and cell cycle withdrawal. Curr Opin Cell Biol. 1994 Dec; 6(6):788-94. Lassar AB, Skapek SX, Novitch B. PMID: 7880524.
      View in: PubMed   Mentions: 96     Fields:    Translation:AnimalsCells
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