Luis De La Torre-Ubieta

Title(s)Assistant Professor-in-Residence, Psychiatry and Biobehavioral Sciences
SchoolMedicine
ORCID ORCID Icon0000-0001-8059-6243 Additional info
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Genetics of cell-type-specific post-transcriptional gene regulation during human neurogenesis. Am J Hum Genet. 2024 Sep 05; 111(9):1877-1898. Aygün N, Vuong C, Krupa O, Mory J, Le BD, Valone JM, Liang D, Shafie B, Zhang P, Salinda A, Wen C, Gandal MJ, Love MI, de la Torre-Ubieta L, Stein JL. PMID: 39168119; PMCID: PMC11393701.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Developmental isoform diversity in the human neocortex informs neuropsychiatric risk mechanisms. Science. 2024 May 24; 384(6698):eadh7688. Patowary A, Zhang P, Jops C, Vuong CK, Ge X, Hou K, Kim M, Gong N, Margolis M, Vo D, Wang X, Liu C, Pasaniuc B, Li JJ, Gandal MJ, de la Torre-Ubieta L. PMID: 38781356.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    3. Developmental isoform diversity in the human neocortex informs neuropsychiatric risk mechanisms. bioRxiv. 2023 Oct 11. Patowary A, Zhang P, Jops C, Vuong CK, Ge X, Hou K, Kim M, Gong N, Margolis M, Vo D, Wang X, Liu C, Pasaniuc B, Li JJ, Gandal MJ, de la Torre-Ubieta L. PMID: 36993726; PMCID: PMC10055310.
      View in: PubMed   Mentions:
    4. MicroRNA-eQTLs in the developing human neocortex link miR-4707-3p expression to brain size. Elife. 2023 Jan 11; 12. Lafferty MJ, Aygün N, Patel NK, Krupa O, Liang D, Wolter JM, Geschwind DH, de la Torre-Ubieta L, Stein JL. PMID: 36629315; PMCID: PMC9859047.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    5. TGFβ superfamily signaling regulates the state of human stem cell pluripotency and capacity to create well-structured telencephalic organoids. Stem Cell Reports. 2022 10 11; 17(10):2220-2238. Watanabe M, Buth JE, Haney JR, Vishlaghi N, Turcios F, Elahi LS, Gu W, Pearson CA, Kurdian A, Baliaouri NV, Collier AJ, Miranda OA, Dunn N, Chen D, Sabri S, Torre-Ubieta L, Clark AT, Plath K, Christofk HR, Kornblum HI, Gandal MJ, Novitch BG. PMID: 36179695; PMCID: PMC9561534.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    6. Defining the evolutionary and gene regulatory logic of vertebrate neuronal diversity. Neuron. 2022 01 05; 110(1):3-5. de la Torre-Ubieta L. PMID: 34990577.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    7. Brain-trait-associated variants impact cell-type-specific gene regulation during neurogenesis. Am J Hum Genet. 2021 09 02; 108(9):1647-1668. Aygün N, Elwell AL, Liang D, Lafferty MJ, Cheek KE, Courtney KP, Mory J, Hadden-Ford E, Krupa O, de la Torre-Ubieta L, Geschwind DH, Love MI, Stein JL. PMID: 34416157; PMCID: PMC8456186.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    8. Cell-type-specific effects of genetic variation on chromatin accessibility during human neuronal differentiation. Nat Neurosci. 2021 07; 24(7):941-953. Liang D, Elwell AL, Aygün N, Krupa O, Wolter JM, Kyere FA, Lafferty MJ, Cheek KE, Courtney KP, Yusupova M, Garrett ME, Ashley-Koch A, Crawford GE, Love MI, de la Torre-Ubieta L, Geschwind DH, Stein JL. PMID: 34017130; PMCID: PMC8254789.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    9. Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia. Nat Neurosci. 2021 06; 24(6):799-809. Kim M, Haney JR, Zhang P, Hernandez LM, Wang LK, Perez-Cano L, Loohuis LMO, de la Torre-Ubieta L, Gandal MJ. PMID: 33958802; PMCID: PMC8178202.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    10. Author Correction: Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders. Nat Commun. 2020 Nov 17; 11(1):5936. Seidlitz J, Nadig A, Liu S, Bethlehem RAI, Vértes PE, Morgan SE, Váša F, Romero-Garcia R, Lalonde FM, Clasen LS, Blumenthal JD, Paquola C, Bernhardt B, Wagstyl K, Polioudakis D, de la Torre-Ubieta L, Geschwind DH, Han JC, Lee NR, Murphy DG, Bullmore ET, Raznahan A. PMID: 33203864; PMCID: PMC7672093.
      View in: PubMed   Mentions: 3     Fields:    
    11. Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders. Nat Commun. 2020 07 03; 11(1):3358. Seidlitz J, Nadig A, Liu S, Bethlehem RAI, Vértes PE, Morgan SE, Váša F, Romero-Garcia R, Lalonde FM, Clasen LS, Blumenthal JD, Paquola C, Bernhardt B, Wagstyl K, Polioudakis D, de la Torre-Ubieta L, Geschwind DH, Han JC, Lee NR, Murphy DG, Bullmore ET, Raznahan A. PMID: 32620757; PMCID: PMC7335069.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansCells
    12. Transcriptomic Insight Into the Polygenic Mechanisms Underlying Psychiatric Disorders. Biol Psychiatry. 2021 01 01; 89(1):54-64. Hernandez LM, Kim M, Hoftman GD, Haney JR, de la Torre-Ubieta L, Pasaniuc B, Gandal MJ. PMID: 32792264; PMCID: PMC7718368.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    13. Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms. Cell. 2020 Apr 30; 181(3):745. Walker RL, Ramaswami G, Hartl C, Mancuso N, Gandal MJ, de la Torre-Ubieta L, Pasaniuc B, Stein JL, Geschwind DH. PMID: 32359439.
      View in: PubMed   Mentions: 10     Fields:    
    14. Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms. Cell. 2019 10 17; 179(3):750-771.e22. Walker RL, Ramaswami G, Hartl C, Mancuso N, Gandal MJ, de la Torre-Ubieta L, Pasaniuc B, Stein JL, Geschwind DH. PMID: 31626773; PMCID: PMC8963725.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansCells
    15. A Single-Cell Transcriptomic Atlas of Human Neocortical Development during Mid-gestation. Neuron. 2019 09 04; 103(5):785-801.e8. Polioudakis D, de la Torre-Ubieta L, Langerman J, Elkins AG, Shi X, Stein JL, Vuong CK, Nichterwitz S, Gevorgian M, Opland CK, Lu D, Connell W, Ruzzo EK, Lowe JK, Hadzic T, Hinz FI, Sabri S, Lowry WE, Gerstein MB, Plath K, Geschwind DH. PMID: 31303374; PMCID: PMC6831089.
      View in: PubMed   Mentions: 210     Fields:    Translation:HumansCells
    16. VOTING-BASED SEGMENTATION OF OVERLAPPING NUCLEI IN CLARITY IMAGES. Proc IEEE Int Symp Biomed Imaging. 2018 Apr; 2018:658-662. Quachtran B, de la Torre Ubieta L, Yusupova M, Geschwind DH, Shattuck DW. PMID: 32038768; PMCID: PMC7007201.
      View in: PubMed   Mentions:
    17. Rbfox1 Regulates Synaptic Transmission through the Inhibitory Neuron-Specific vSNARE Vamp1. Neuron. 2018 04 04; 98(1):127-141.e7. Vuong CK, Wei W, Lee JA, Lin CH, Damianov A, de la Torre-Ubieta L, Halabi R, Otis KO, Martin KC, O'Dell TJ, Black DL. PMID: 29621484; PMCID: PMC5890944.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    18. The Dynamic Landscape of Open Chromatin during Human Cortical Neurogenesis. Cell. 2018 01 11; 172(1-2):289-304.e18. de la Torre-Ubieta L, Stein JL, Won H, Opland CK, Liang D, Lu D, Geschwind DH. PMID: 29307494; PMCID: PMC5924568.
      View in: PubMed   Mentions: 164     Fields:    Translation:HumansCells
    19. Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection. Cell Rep. 2017 Oct 10; 21(2):517-532. Watanabe M, Buth JE, Vishlaghi N, de la Torre-Ubieta L, Taxidis J, Khakh BS, Coppola G, Pearson CA, Yamauchi K, Gong D, Dai X, Damoiseaux R, Aliyari R, Liebscher S, Schenke-Layland K, Caneda C, Huang EJ, Zhang Y, Cheng G, Geschwind DH, Golshani P, Sun R, Novitch BG. PMID: 29020636; PMCID: PMC5637483.
      View in: PubMed   Mentions: 191     Fields:    Translation:HumansCells
    20. Chromosome conformation elucidates regulatory relationships in developing human brain. Nature. 2016 10 27; 538(7626):523-527. Won H, de la Torre-Ubieta L, Stein JL, Parikshak NN, Huang J, Opland CK, Gandal MJ, Sutton GJ, Hormozdiari F, Lu D, Lee C, Eskin E, Voineagu I, Ernst J, Geschwind DH. PMID: 27760116; PMCID: PMC5358922.
      View in: PubMed   Mentions: 297     Fields:    Translation:HumansCells
    21. Advancing the understanding of autism disease mechanisms through genetics. Nat Med. 2016 Apr; 22(4):345-61. de la Torre-Ubieta L, Won H, Stein JL, Geschwind DH. PMID: 27050589; PMCID: PMC5072455.
      View in: PubMed   Mentions: 388     Fields:    Translation:HumansAnimals
    22. Human neural stem cell-derived cultures in three-dimensional substrates form spontaneously functional neuronal networks. J Tissue Eng Regen Med. 2017 04; 11(4):1022-1033. Smith I, Silveirinha V, Stein JL, de la Torre-Ubieta L, Farrimond JA, Williamson EM, Whalley BJ. PMID: 25712225.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    23. A quantitative framework to evaluate modeling of cortical development by neural stem cells. Neuron. 2014 Jul 02; 83(1):69-86. Stein JL, de la Torre-Ubieta L, Tian Y, Parikshak NN, Hernández IA, Marchetto MC, Baker DK, Lu D, Hinman CR, Lowe JK, Wexler EM, Muotri AR, Gage FH, Kosik KS, Geschwind DH. PMID: 24991955; PMCID: PMC4277209.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansCells
    24. A novel Hap1-Tsc1 interaction regulates neuronal mTORC1 signaling and morphogenesis in the brain. J Neurosci. 2013 Nov 13; 33(46):18015-21. Mejia LA, Litterman N, Ikeuchi Y, de la Torre-Ubieta L, Bennett EJ, Zhang C, Harper JW, Bonni A. PMID: 24227713; PMCID: PMC3828457.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    25. The XLID protein PQBP1 and the GTPase Dynamin 2 define a signaling link that orchestrates ciliary morphogenesis in postmitotic neurons. Cell Rep. 2013 Sep 12; 4(5):879-89. Ikeuchi Y, de la Torre-Ubieta L, Matsuda T, Steen H, Okazawa H, Bonni A. PMID: 23994472; PMCID: PMC4013279.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    26. FoxO6 regulates memory consolidation and synaptic function. Genes Dev. 2012 Dec 15; 26(24):2780-801. Salih DA, Rashid AJ, Colas D, de la Torre-Ubieta L, Zhu RP, Morgan AA, Santo EE, Ucar D, Devarajan K, Cole CJ, Madison DV, Shamloo M, Butte AJ, Bonni A, Josselyn SA, Brunet A. PMID: 23222102; PMCID: PMC3533081.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    27. A conserved PTEN/FOXO pathway regulates neuronal morphology during C. elegans development. Development. 2011 Dec; 138(23):5257-67. Christensen R, de la Torre-Ubieta L, Bonni A, Colón-Ramos DA. PMID: 22069193; PMCID: PMC3210501.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    28. Transcriptional regulation of neuronal polarity and morphogenesis in the mammalian brain. Neuron. 2011 Oct 06; 72(1):22-40. de la Torre-Ubieta L, Bonni A. PMID: 21982366; PMCID: PMC3391704.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    29. An isoform-specific SnoN1-FOXO1 repressor complex controls neuronal morphogenesis and positioning in the mammalian brain. Neuron. 2011 Mar 10; 69(5):930-44. Huynh MA, Ikeuchi Y, Netherton S, de la Torre-Ubieta L, Kanadia R, Stegmüller J, Cepko C, Bonni S, Bonni A. PMID: 21382553; PMCID: PMC3073069.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    30. A JIP3-regulated GSK3β/DCX signaling pathway restricts axon branching. J Neurosci. 2010 Dec 15; 30(50):16766-76. Bilimoria PM, de la Torre-Ubieta L, Ikeuchi Y, Becker EB, Reiner O, Bonni A. PMID: 21159948; PMCID: PMC3409248.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    31. A FOXO-Pak1 transcriptional pathway controls neuronal polarity. Genes Dev. 2010 Apr 15; 24(8):799-813. de la Torre-Ubieta L, Gaudillière B, Yang Y, Ikeuchi Y, Yamada T, DiBacco S, Stegmüller J, Schüller U, Salih DA, Rowitch D, Brunet A, Bonni A. PMID: 20395366; PMCID: PMC2854394.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    32. Combinatorial assembly of neurons: from chromatin to dendrites. Trends Cell Biol. 2008 Feb; 18(2):48-51. de la Torre-Ubieta L, Bonni A. PMID: 18222691.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    33. The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell. 2007 Mar 23; 128(6):1077-88. Iwase S, Lan F, Bayliss P, de la Torre-Ubieta L, Huarte M, Qi HH, Whetstine JR, Bonni A, Roberts TM, Shi Y. PMID: 17320160.
      View in: PubMed   Mentions: 346     Fields:    Translation:HumansAnimalsCells
    34. Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth. Nature. 2006 Jul 27; 442(7101):471-4. Lasorella A, Stegmüller J, Guardavaccaro D, Liu G, Carro MS, Rothschild G, de la Torre-Ubieta L, Pagano M, Bonni A, Iavarone A. PMID: 16810178.
      View in: PubMed   Mentions: 145     Fields:    Translation:HumansCells
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