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Abramson, Jeffrey S

Title(s)Professor, Physiology
Phone3108253913
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    Collapse Research 
    Collapse Research Activities and Funding
    Deciphering molecular details of cellular sugar transport and their roles in disease
    NIH/NIGMS R35GM135175Jan 1, 2020 - Dec 31, 2024
    Role: Principal Investigator
    Functional and structural studies of unique pathogenic transporters involved in glycobiology
    NIH/NIGMS R01GM124783Aug 1, 2017 - Apr 30, 2021
    Role: Principal Investigator
    Structural and functional characterization of sugar transporters in health and disease
    NIH/NIGMS R01GM078844Aug 13, 2009 - Sep 19, 2011
    Role: Principal Investigator
    Structure/Function Studies on the Ca2+: Cation Antiporter family of transporters
    NIH/NHLBI R21HL093278Apr 1, 2009 - Mar 31, 2012
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Queralt-Martín M, Bergdoll L, Teijido O, Munshi N, Jacobs D, Kuszak AJ, Protchenko O, Reina S, Magrì A, De Pinto V, Bezrukov SM, Abramson J, Rostovtseva TK. A lower affinity to cytosolic proteins reveals VDAC3 isoform-specific role in mitochondrial biology. J Gen Physiol. 2020 Feb 03; 152(2). PMID: 31935282.
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    2. Althoff T, Abramson J. Protein structure reveals how a malaria parasite imports a wide range of sugars. Nature. 2020 02; 578(7794):220-221. PMID: 32042087.
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    3. Cheng WWL, Budelier MM, Sugasawa Y, Bergdoll L, Queralt-Martín M, Rosencrans W, Rostovtseva TK, Chen ZW, Abramson J, Krishnan K, Covey DF, Whitelegge JP, Evers AS. Multiple neurosteroid and cholesterol binding sites in voltage-dependent anion channel-1 determined by photo-affinity labeling. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 10; 1864(10):1269-1279. PMID: 31176038.
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    4. Pantazis A, Westerberg K, Althoff T, Abramson J, Olcese R. Harnessing photoinduced electron transfer to optically determine protein sub-nanoscale atomic distances. Nat Commun. 2018 11 09; 9(1):4738. PMID: 30413716.
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    5. Queralt-Martín M, Bergdoll L, Jacobs D, Bezrukov SM, Abramson J, Rostovtseva TK. Assessing the role of residue E73 and lipid headgroup charge in VDAC1 voltage gating. Biochim Biophys Acta Bioenerg. 2019 01; 1860(1):22-29. PMID: 30412693.
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    6. Wahlgren WY, Dunevall E, North RA, Paz A, Scalise M, Bisignano P, Bengtsson-Palme J, Goyal P, Claesson E, Caing-Carlsson R, Andersson R, Beis K, Nilsson UJ, Farewell A, Pochini L, Indiveri C, Grabe M, Dobson RCJ, Abramson J, Ramaswamy S, Friemann R. Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site. Nat Commun. 2018 05 01; 9(1):1753. PMID: 29717135.
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    7. Paz A, Claxton DP, Kumar JP, Kazmier K, Bisignano P, Sharma S, Nolte SA, Liwag TM, Nayak V, Wright EM, Grabe M, Mchaourab HS, Abramson J. Conformational transitions of the sodium-dependent sugar transporter, vSGLT. Proc Natl Acad Sci U S A. 2018 03 20; 115(12):E2742-E2751. PMID: 29507231.
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    8. Bergdoll LA, Lerch MT, Patrick JW, Belardo K, Altenbach C, Bisignano P, Laganowsky A, Grabe M, Hubbell WL, Abramson J. Protonation state of glutamate 73 regulates the formation of a specific dimeric association of mVDAC1. Proc Natl Acad Sci U S A. 2018 01 09; 115(2):E172-E179. PMID: 29279396.
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    9. Hoogerheide DP, Noskov SY, Jacobs D, Bergdoll L, Silin V, Worcester DL, Abramson J, Nanda H, Rostovtseva TK, Bezrukov SM. Structural features and lipid binding domain of tubulin on biomimetic mitochondrial membranes. Proc Natl Acad Sci U S A. 2017 05 02; 114(18):E3622-E3631. PMID: 28420794.
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    10. Budelier MM, Cheng WWL, Bergdoll L, Chen ZW, Janetka JW, Abramson J, Krishnan K, Mydock-McGrane L, Covey DF, Whitelegge JP, Evers AS. Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1. J Biol Chem. 2017 06 02; 292(22):9294-9304. PMID: 28396346.
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    11. Budelier MM, Cheng WW, Bergdoll L, Chen ZW, Abramson J, Krishnan K, Qian M, Covey DF, Janetka JW, Evers AS. Click Chemistry Reagent for Identification of Sites of Covalent Ligand Incorporation in Integral Membrane Proteins. Anal Chem. 2017 02 21; 89(4):2636-2644. PMID: 28194953.
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    12. Adelman JL, Ghezzi C, Bisignano P, Loo DD, Choe S, Abramson J, Rosenberg JM, Wright EM, Grabe M. Stochastic steps in secondary active sugar transport. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):E3960-6. PMID: 27325773.
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    13. Srikanth S, Kim KD, Gao Y, Woo JS, Ghosh S, Calmettes G, Paz A, Abramson J, Jiang M, Gwack Y. A large Rab GTPase encoded by CRACR2A is a component of subsynaptic vesicles that transmit T cell activation signals. Sci Signal. 2016 Mar 22; 9(420):ra31. PMID: 27016526.
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    14. Ji J, Lee H, Argiropoulos B, Dorrani N, Mann J, Martinez-Agosto JA, Gomez-Ospina N, Gallant N, Bernstein JA, Hudgins L, Slattery L, Isidor B, Le Caignec C, David A, Obersztyn E, Wisniowiecka-Kowalnik B, Fox M, Deignan JL, Vilain E, Hendricks E, Horton Harr M, Noon SE, Jackson JR, Wilkens A, Mirzaa G, Salamon N, Abramson J, Zackai EH, Krantz I, Innes AM, Nelson SF, Grody WW, Quintero-Rivera F. DYRK1A haploinsufficiency causes a new recognizable syndrome with microcephaly, intellectual disability, speech impairment, and distinct facies. Eur J Hum Genet. 2015 Nov; 23(11):1473-81. PMID: 25944381.
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    15. Li Z, Lee AS, Bracher S, Jung H, Paz A, Kumar JP, Abramson J, Quick M, Shi L. Identification of a second substrate-binding site in solute-sodium symporters. J Biol Chem. 2015 Mar 20; 290(12):7361. PMID: 25795729.
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    16. Li Z, Lee AS, Bracher S, Jung H, Paz A, Kumar JP, Abramson J, Quick M, Shi L. Identification of a second substrate-binding site in solute-sodium symporters. J Biol Chem. 2015 Jan 02; 290(1):127-41. PMID: 25398883.
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    17. Choudhary OP, Paz A, Adelman JL, Colletier JP, Abramson J, Grabe M. Structure-guided simulations illuminate the mechanism of ATP transport through VDAC1. Nat Struct Mol Biol. 2014 Jul; 21(7):626-32. PMID: 24908397.
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    18. Adelman JL, Sheng Y, Choe S, Abramson J, Wright EM, Rosenberg JM, Grabe M. Structural determinants of water permeation through the sodium-galactose transporter vSGLT. Biophys J. 2014 Mar 18; 106(6):1280-9. PMID: 24655503.
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    19. Schredelseker J, Paz A, López CJ, Altenbach C, Leung CS, Drexler MK, Chen JN, Hubbell WL, Abramson J. High resolution structure and double electron-electron resonance of the zebrafish voltage-dependent anion channel 2 reveal an oligomeric population. J Biol Chem. 2014 May 02; 289(18):12566-77. PMID: 24627492.
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    20. Abramson J, Vartanian AS. Biochemistry. Watch water flow. Science. 2013 Jun 14; 340(6138):1294-5. PMID: 23766318.
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    21. Vartanian AS, Paz A, Fortgang EA, Abramson J, Dahlquist FW. Structure of flagellar motor proteins in complex allows for insights into motor structure and switching. J Biol Chem. 2012 Oct 19; 287(43):35779-83. PMID: 22896702.
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    22. Srikanth S, Jew M, Kim KD, Yee MK, Abramson J, Gwack Y. Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1). Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8682-7. PMID: 22586105.
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    23. Abramson J, Paz A, Philipson KD. Structural biology. It's all in the symmetry. Science. 2012 Feb 10; 335(6069):669-70. PMID: 22323810.
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    24. Besserer GM, Nicoll DA, Abramson J, Philipson KD. Characterization and purification of a Na+/Ca2+ exchanger from an archaebacterium. J Biol Chem. 2012 Mar 09; 287(11):8652-9. PMID: 22287543.
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    25. Teijido O, Ujwal R, Hillerdal CO, Kullman L, Rostovtseva TK, Abramson J. Affixing N-terminal a-helix to the wall of the voltage-dependent anion channel does not prevent its voltage gating. J Biol Chem. 2012 Mar 30; 287(14):11437-45. PMID: 22275367.
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    26. Ujwal R, Abramson J. High-throughput crystallization of membrane proteins using the lipidic bicelle method. J Vis Exp. 2012 Jan 09; (59):e3383. PMID: 22257923.
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    27. Sala-Rabanal M, Hirayama BA, Loo DD, Chaptal V, Abramson J, Wright EM. Bridging the gap between structure and kinetics of human SGLT1. Am J Physiol Cell Physiol. 2012 May 01; 302(9):C1293-305. PMID: 22159082.
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    28. Chaptal V, Kwon S, Sawaya MR, Guan L, Kaback HR, Abramson J. Crystal structure of lactose permease in complex with an affinity inactivator yields unique insight into sugar recognition. Proc Natl Acad Sci U S A. 2011 Jun 07; 108(23):9361-6. PMID: 21593407.
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    29. Watanabe A, Choe S, Chaptal V, Rosenberg JM, Wright EM, Grabe M, Abramson J. The mechanism of sodium and substrate release from the binding pocket of vSGLT. Nature. 2010 Dec 16; 468(7326):988-91. PMID: 21131949.
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    30. Choe S, Rosenberg JM, Abramson J, Wright EM, Grabe M. Water permeation through the sodium-dependent galactose cotransporter vSGLT. Biophys J. 2010 Oct 06; 99(7):L56-8. PMID: 20923633.
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    31. Hsieh JM, Tsirulnikov K, Sawaya MR, Magilnick N, Abuladze N, Kurtz I, Abramson J, Pushkin A. Structures of aminoacylase 3 in complex with acetylated substrates. Proc Natl Acad Sci U S A. 2010 Oct 19; 107(42):17962-7. PMID: 20921362.
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    32. Westenhoff S, Malmerberg E, Arnlund D, Johansson L, Nazarenko E, Cammarata M, Davidsson J, Chaptal V, Abramson J, Katona G, Menzel A, Neutze R. Rapid readout detector captures protein time-resolved WAXS. Nat Methods. 2010 Oct; 7(10):775-6. PMID: 20885435.
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    33. Lin MC, Abramson J, Papazian DM. Transfer of ion binding site from ether-a-go-go to Shaker: Mg2+ binds to resting state to modulate channel opening. J Gen Physiol. 2010 May; 135(5):415-31. PMID: 20385745.
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    34. Hsieh JM, Besserer GM, Madej MG, Bui HQ, Kwon S, Abramson J. Bridging the gap: a GFP-based strategy for overexpression and purification of membrane proteins with intra and extracellular C-termini. Protein Sci. 2010 Apr; 19(4):868-80. PMID: 20196076.
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    35. Chaptal V, Ujwal R, Nie Y, Watanabe A, Kwon S, Abramson J. Fluorescence Detection of Heavy Atom Labeling (FD-HAL): a rapid method for identifying covalently modified cysteine residues by phasing atoms. J Struct Biol. 2010 Jul; 171(1):82-7. PMID: 20152903.
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    36. Ryan CM, Souda P, Bassilian S, Ujwal R, Zhang J, Abramson J, Ping P, Durazo A, Bowie JU, Hasan SS, Baniulis D, Cramer WA, Faull KF, Whitelegge JP. Post-translational modifications of integral membrane proteins resolved by top-down Fourier transform mass spectrometry with collisionally activated dissociation. Mol Cell Proteomics. 2010 May; 9(5):791-803. PMID: 20093275.
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    37. Kracun S, Chaptal V, Abramson J, Khakh BS. Gated access to the pore of a P2X receptor: structural implications for closed-open transitions. J Biol Chem. 2010 Mar 26; 285(13):10110-21. PMID: 20093367.
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    38. Choudhary OP, Ujwal R, Kowallis W, Coalson R, Abramson J, Grabe M. The electrostatics of VDAC: implications for selectivity and gating. J Mol Biol. 2010 Feb 26; 396(3):580-92. PMID: 20005234.
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    39. Abramson J, Chaptal V. Keeping an eye on membrane transport by TR-WAXS. Structure. 2009 Sep 09; 17(9):1153-5. PMID: 19748336.
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    40. Abramson J, Wright EM. Structure and function of Na(+)-symporters with inverted repeats. Curr Opin Struct Biol. 2009 Aug; 19(4):425-32. PMID: 19631523.
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    41. Ujwal R, Cascio D, Chaptal V, Ping P, Abramson J. Crystal packing analysis of murine VDAC1 crystals in a lipidic environment reveals novel insights on oligomerization and orientation. Channels (Austin). 2009 May-Jun; 3(3):167-70. PMID: 19574737.
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    42. Chaptal V, Ottolia M, Mercado-Besserer G, Nicoll DA, Philipson KD, Abramson J. Structure and functional analysis of a Ca2+ sensor mutant of the Na+/Ca2+ exchanger. J Biol Chem. 2009 May 29; 284(22):14688-92. PMID: 19332552.
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    43. Ujwal R, Cascio D, Colletier JP, Faham S, Zhang J, Toro L, Ping P, Abramson J. The crystal structure of mouse VDAC1 at 2.3 A resolution reveals mechanistic insights into metabolite gating. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17742-7. PMID: 18988731.
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    44. Faham S, Watanabe A, Besserer GM, Cascio D, Specht A, Hirayama BA, Wright EM, Abramson J. The crystal structure of a sodium galactose transporter reveals mechanistic insights into Na+/sugar symport. Science. 2008 Aug 08; 321(5890):810-4. PMID: 18599740.
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    45. Chaptal V, Besserer GM, Ottolia M, Nicoll DA, Cascio D, Philipson KD, Abramson J. How does regulatory Ca2+ regulate the Na+-Ca2+ exchanger? Channels (Austin). 2007 Nov-Dec; 1(6):397-9. PMID: 18690047.
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    46. Besserer GM, Ottolia M, Nicoll DA, Chaptal V, Cascio D, Philipson KD, Abramson J. The second Ca2+-binding domain of the Na+ Ca2+ exchanger is essential for regulation: crystal structures and mutational analysis. Proc Natl Acad Sci U S A. 2007 Nov 20; 104(47):18467-72. PMID: 17962412.
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    47. Nicoll DA, Ren X, Ottolia M, Phillips M, Paredes AR, Abramson J, Philipson KD. What we know about the structure of NCX1 and how it relates to its function. Ann N Y Acad Sci. 2007 Mar; 1099:1-6. PMID: 17303833.
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    48. Nicoll DA, Sawaya MR, Kwon S, Cascio D, Philipson KD, Abramson J. The crystal structure of the primary Ca2+ sensor of the Na+/Ca2+ exchanger reveals a novel Ca2+ binding motif. J Biol Chem. 2006 Aug 04; 281(31):21577-81. PMID: 16774926.
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    49. Abramson J, Kaback HR, Iwata S. Structural comparison of lactose permease and the glycerol-3-phosphate antiporter: members of the major facilitator superfamily. Curr Opin Struct Biol. 2004 Aug; 14(4):413-9. PMID: 15313234.
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    50. Abramson J, Iwata S, Kaback HR. Lactose permease as a paradigm for membrane transport proteins (Review). Mol Membr Biol. 2004 Jul-Aug; 21(4):227-36. PMID: 15371012.
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    51. Abramson J, Smirnova I, Kasho V, Verner G, Iwata S, Kaback HR. The lactose permease of Escherichia coli: overall structure, the sugar-binding site and the alternating access model for transport. FEBS Lett. 2003 Nov 27; 555(1):96-101. PMID: 14630326.
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    52. Abramson J, Smirnova I, Kasho V, Verner G, Kaback HR, Iwata S. Structure and mechanism of the lactose permease of Escherichia coli. Science. 2003 Aug 01; 301(5633):610-5. PMID: 12893935.
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    53. Iwata M, Abramson J, Byrne B, Iwata S. Structure and function of quinone binding membrane proteins. Adv Protein Chem. 2003; 63:151-76. PMID: 12629970.
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    54. Svensson-Ek M, Abramson J, Larsson G, Törnroth S, Brzezinski P, Iwata S. The X-ray crystal structures of wild-type and EQ(I-286) mutant cytochrome c oxidases from Rhodobacter sphaeroides. J Mol Biol. 2002 Aug 09; 321(2):329-39. PMID: 12144789.
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    55. Jormakka M, Törnroth S, Abramson J, Byrne B, Iwata S. Purification and crystallization of the respiratory complex formate dehydrogenase-N from Escherichia coli. Acta Crystallogr D Biol Crystallogr. 2002 Jan; 58(Pt 1):160-2. PMID: 11752799.
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