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Pushkin, Alexander V

Title(s)Adjunct Professor, Medicine
SchoolNephrology
Phone3102066741
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    Collapse Research 
    Collapse Research Activities and Funding
    Biology of Mercapturic Acid Mediated Nephrotoxicity
    NIH/NIEHS R01ES012935Jul 25, 2005 - Apr 30, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kao L, Azimov R, Shao XM, Abuladze N, Newman D, Zhekova H, Noskov S, Pushkin A, Kurtz I. SLC4A11 function: evidence for H+(OH-) and NH3-H+ transport. Am J Physiol Cell Physiol. 2020 Feb 01; 318(2):C392-C405. PMID: 31774702.
      View in: PubMed
    2. Huynh KW, Jiang J, Abuladze N, Tsirulnikov K, Kao L, Shao X, Newman D, Azimov R, Pushkin A, Zhou ZH, Kurtz I. CryoEM structure of the human SLC4A4 sodium-coupled acid-base transporter NBCe1. Nat Commun. 2018 03 02; 9(1):900. PMID: 29500354.
      View in: PubMed
    3. Tsirulnikov K, Duarte S, Ray A, Datta N, Zarrinpar A, Hwang L, Faull K, Pushkin A, Kurtz I. Aminoacylase 3 Is a New Potential Marker and Therapeutic Target in Hepatocellular Carcinoma. J Cancer. 2018; 9(1):1-12. PMID: 29290764.
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    4. Jiang J, Magilnick N, Tsirulnikov K, Abuladze N, Atanasov I, Ge P, Narla M, Pushkin A, Zhou ZH, Kurtz I. Single particle electron microscopy analysis of the bovine anion exchanger 1 reveals a flexible linker connecting the cytoplasmic and membrane domains. PLoS One. 2013; 8(2):e55408. PMID: 23393575.
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    5. Tsirulnikov K, Abuladze N, Vahi R, Hasnain H, Phillips M, Ryan CM, Atanasov I, Faull KF, Kurtz I, Pushkin A. Aminoacylase 3 binds to and cleaves the N-terminus of the hepatitis C virus core protein. FEBS Lett. 2012 Nov 02; 586(21):3799-804. PMID: 23010594.
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    6. Tsirulnikov K, Abuladze N, Bragin A, Faull K, Cascio D, Damoiseaux R, Schibler MJ, Pushkin A. Inhibition of aminoacylase 3 protects rat brain cortex neuronal cells from the toxicity of 4-hydroxy-2-nonenal mercapturate and 4-hydroxy-2-nonenal. Toxicol Appl Pharmacol. 2012 Sep 15; 263(3):303-14. PMID: 22819785.
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    7. Hsieh JM, Tsirulnikov K, Sawaya MR, Magilnick N, Abuladze N, Kurtz I, Abramson J, Pushkin A. Structures of aminoacylase 3 in complex with acetylated substrates. Proc Natl Acad Sci U S A. 2010 Oct 19; 107(42):17962-7. PMID: 20921362.
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    8. Zhu Q, Kao L, Azimov R, Abuladze N, Newman D, Pushkin A, Liu W, Chang C, Kurtz I. Structural and functional characterization of the C-terminal transmembrane region of NBCe1-A. J Biol Chem. 2010 Nov 26; 285(48):37178-87. PMID: 20837482.
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    9. Zhu Q, Kao L, Azimov R, Newman D, Liu W, Pushkin A, Abuladze N, Kurtz I. Topological location and structural importance of the NBCe1-A residues mutated in proximal renal tubular acidosis. J Biol Chem. 2010 Apr 30; 285(18):13416-26. PMID: 20197274.
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    10. Tsirulnikov K, Abuladze N, Koag MC, Newman D, Scholz K, Bondar G, Zhu Q, Avliyakulov NK, Dekant W, Faull K, Kurtz I, Pushkin A. Transport of N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine, a metabolite of trichloroethylene, by mouse multidrug resistance associated protein 2 (Mrp2). Toxicol Appl Pharmacol. 2010 Apr 15; 244(2):218-25. PMID: 20060011.
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    11. Lopez IA, Rosenblatt MI, Kim C, Galbraith GC, Jones SM, Kao L, Newman D, Liu W, Yeh S, Pushkin A, Abuladze N, Kurtz I. Slc4a11 gene disruption in mice: cellular targets of sensorineuronal abnormalities. J Biol Chem. 2009 Sep 25; 284(39):26882-96. PMID: 19586905.
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    12. Tsirulnikov K, Abuladze N, Newman D, Ryazantsev S, Wolak T, Magilnick N, Koag MC, Kurtz I, Pushkin A. Mouse aminoacylase 3: a metalloenzyme activated by cobalt and nickel. Biochim Biophys Acta. 2009 Jul; 1794(7):1049-57. PMID: 19362172.
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    13. Zhu Q, Azimov R, Kao L, Newman D, Liu W, Abuladze N, Pushkin A, Kurtz I. NBCe1-A Transmembrane Segment 1 Lines the Ion Translocation Pathway. J Biol Chem. 2009 Mar 27; 284(13):8918-29. PMID: 19158093.
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    14. Kao L, Sassani P, Azimov R, Pushkin A, Abuladze N, Peti-Peterdi J, Liu W, Newman D, Kurtz I. Oligomeric structure and minimal functional unit of the electrogenic sodium bicarbonate cotransporter NBCe1-A. J Biol Chem. 2008 Sep 26; 283(39):26782-94. PMID: 18658147.
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    15. Azimov R, Abuladze N, Sassani P, Newman D, Kao L, Liu W, Orozco N, Ruchala P, Pushkin A, Kurtz I. G418-mediated ribosomal read-through of a nonsense mutation causing autosomal recessive proximal renal tubular acidosis. Am J Physiol Renal Physiol. 2008 Sep; 295(3):F633-41. PMID: 18614622.
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    16. Pushkin A, Kurtz I. Measurement of aminoacylases. Curr Protoc Toxicol. 2008 Feb; Chapter 6:Unit6.14. PMID: 23045009.
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    17. Ryazantsev S, Abuladze N, Newman D, Bondar G, Kurtz I, Pushkin A. Structural characterization of dimeric murine aminoacylase III. FEBS Lett. 2007 May 01; 581(9):1898-902. PMID: 17434493.
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    18. Newman D, Abuladze N, Scholz K, Dekant W, Tsuprun V, Ryazantsev S, Bondar G, Sassani P, Kurtz I, Pushkin A. Specificity of aminoacylase III-mediated deacetylation of mercapturic acids. Drug Metab Dispos. 2007 Jan; 35(1):43-50. PMID: 17012540.
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    19. Pushkin A, Kurtz I. SLC4 base (HCO3 -, CO3 2-) transporters: classification, function, structure, genetic diseases, and knockout models. Am J Physiol Renal Physiol. 2006 Mar; 290(3):F580-99. PMID: 16461757.
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    20. Abuladze N, Azimov R, Newman D, Sassani P, Liu W, Tatishchev S, Pushkin A, Kurtz I. Critical amino acid residues involved in the electrogenic sodium-bicarbonate cotransporter kNBC1-mediated transport. J Physiol. 2005 Jun 15; 565(Pt 3):717-30. PMID: 15817634.
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    21. Pushkin A, Abuladze N, Gross E, Newman D, Tatishchev S, Lee I, Fedotoff O, Bondar G, Azimov R, Ngyuen M, Kurtz I. Molecular mechanism of kNBC1-carbonic anhydrase II interaction in proximal tubule cells. J Physiol. 2004 Aug 15; 559(Pt 1):55-65. PMID: 15218065.
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    22. Abuladze N, Pushkin A, Tatishchev S, Newman D, Sassani P, Kurtz I. Expression and localization of rat NBC4c in liver and renal uroepithelium. Am J Physiol Cell Physiol. 2004 Sep; 287(3):C781-9. PMID: 15151908.
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    23. Pushkin A, Carpenito G, Abuladze N, Newman D, Tsuprun V, Ryazantsev S, Motemoturu S, Sassani P, Solovieva N, Dukkipati R, Kurtz I. Structural characterization, tissue distribution, and functional expression of murine aminoacylase III. Am J Physiol Cell Physiol. 2004 Apr; 286(4):C848-56. PMID: 14656720.
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    24. Bok D, Galbraith G, Lopez I, Woodruff M, Nusinowitz S, BeltrandelRio H, Huang W, Zhao S, Geske R, Montgomery C, Van Sligtenhorst I, Friddle C, Platt K, Sparks MJ, Pushkin A, Abuladze N, Ishiyama A, Dukkipati R, Liu W, Kurtz I. Blindness and auditory impairment caused by loss of the sodium bicarbonate cotransporter NBC3. Nat Genet. 2003 Jul; 34(3):313-9. PMID: 12808454.
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    25. Tatishchev S, Abuladze N, Pushkin A, Newman D, Liu W, Weeks D, Sachs G, Kurtz I. Identification of membrane topography of the electrogenic sodium bicarbonate cotransporter pNBC1 by in vitro transcription/translation. Biochemistry. 2003 Jan 28; 42(3):755-65. PMID: 12534288.
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    26. Pushkin A, Abuladze N, Newman D, Muronets V, Sassani P, Tatishchev S, Kurtz I. The COOH termini of NBC3 and the 56-kDa H+-ATPase subunit are PDZ motifs involved in their interaction. Am J Physiol Cell Physiol. 2003 Mar; 284(3):C667-73. PMID: 12444018.
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    27. Gross E, Pushkin A, Abuladze N, Fedotoff O, Kurtz I. Regulation of the sodium bicarbonate cotransporter kNBC1 function: role of Asp(986), Asp(988) and kNBC1-carbonic anhydrase II binding. J Physiol. 2002 11 01; 544(3):679-85. PMID: 12411514.
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    28. Park M, Ko SB, Choi JY, Muallem G, Thomas PJ, Pushkin A, Lee MS, Kim JY, Lee MG, Muallem S, Kurtz I. The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3- cotransport isoform 3. J Biol Chem. 2002 Dec 27; 277(52):50503-9. PMID: 12403779.
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    29. Sassani P, Pushkin A, Gross E, Gomer A, Abuladze N, Dukkipati R, Carpenito G, Kurtz I. Functional characterization of NBC4: a new electrogenic sodium-bicarbonate cotransporter. Am J Physiol Cell Physiol. 2002 Feb; 282(2):C408-16. PMID: 11788353.
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    30. Pushkin A, Abuladze N, Newman D, Tatishchev S, Kurtz I. Genomic organization of the DCTN1-SLC4A5 locus encoding both NBC4 and p150(Glued). Cytogenet Cell Genet. 2001; 95(3-4):163-8. PMID: 12063394.
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    31. Pushkin AV, Tsuprun VL, Abuladze NK, Newman D, Kurtz I. Oligomeric structure of bAE3 protein. IUBMB Life. 2000 Dec; 50(6):397-401. PMID: 11327314.
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    32. Pushkin A, Abuladze N, Newman D, Lee I, Xu G, Kurtz I. Two C-terminal variants of NBC4, a new member of the sodium bicarbonate cotransporter family: cloning, characterization, and localization. IUBMB Life. 2000 Jul; 50(1):13-9. PMID: 11087115.
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    33. Tsuprun VL, Boekema EJ, Pushkin AV, Tagunova IV. Electron microscopy and image analysis of the GroEL-like protein and its complexes with glutamine synthetase from pea leaves. Biochim Biophys Acta. 1992 Jan 30; 1099(1):67-73. PMID: 1346750.
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    34. Tsuprun VL, Boekema EJ, Samsonidze TG, Pushkin AV. Electron microscopy of the complexes of ribulose-1,5-bisphosphate carboxylase (Rubisco) and Rubisco subunit-binding protein from pea leaves. FEBS Lett. 1991 Sep 09; 289(2):205-9. PMID: 1915848.
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    35. Pushkin AV, Tsuprun VL, Solov'eva NA, Shubin VV, Evstigneeva ZG. [High molecular weight protein consisting of 14 monomers from pea leaves]. Biokhimiia. 1983 Sep; 48(9):1441-6. PMID: 6626605.
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    36. Evstigneeva ZG, Pushkin AV, Solovieva NA, Golova TV, Kretovich WL. Effect of light on the formation of multiple molecular forms of glutamine synthetase in plants. Mol Cell Biochem. 1981 Oct 30; 40(2):123-5. PMID: 6118828.
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    37. Tsuprun VL, Samsonidze TG, Radukina NA, Pushkin AV, Evstigneeva ZG, Kretovich WL. Electron microscopy of glutamine synthetase from pea leaf chloroplasts. Biochim Biophys Acta. 1980 Nov 20; 626(1):1-4. PMID: 6109548.
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