Sonal Srikanth

Title(s)Associate Adjunct Professor, Physiology
ORCID ORCID Icon0000-0002-3034-095X Additional info
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    National Center for Biological Sciences, TIFR, IndiaPh.D07/2004Genetics and Biophysics

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    Dr. Srikanth is currently an Adjunct Assistant Professor of Physiology in the David Geffen School of Medicine at UCLA. Dr. Srikanth obtained her Ph.D from NCBS, Bangalore under the guidance of Dr. Gaiti Hasan in characterizing the biophysical properties of the Drosophila melanogaster Inositol 1, 4, 5 trisphosphate receptor (InsP3R). During her Ph.D. she spent a year in Dr. Ilya Bezprozvanny's lab at UT Southwestern Medical center performing lipid bilayer experiments to examine the single channel properties of the Drosophila InsP3R. She then joined Dr. Anjana Rao's laboratory, then at Harvard Medical School and performed a genome-wide Drosophila RNAi screen with Dr. Yousang Gwack, which led to the identification of Orai1 as a critical component of the Ca2+ release-activated Ca2+ (CRAC) channels in immune cells. She further continued her research on Orai proteins in Yousang's lab at UCLA, first as a postdoctoral scholar and subsequently as an Assistant Research Physiologist.
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    Regulation of the STING pathway under sterile conditions
    NIH R01AI146352Aug 13, 2020 - Jul 31, 2024
    Role: Principal Investigator
    Distinct functions of Orai1 and Orai2 in naive and effector helper T cells
    NIH R21AI130653Mar 1, 2017 - Feb 29, 2020
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Orai inhibition modulates pulmonary ILC2 metabolism and alleviates airway hyperreactivity in murine and humanized models. Nat Commun. 2023 Sep 26; 14(1):5989. Howard E, Hurrell BP, Helou DG, Shafiei-Jahani P, Hasiakos S, Painter J, Srikanth S, Gwack Y, Akbari O. PMID: 37752127; PMCID: PMC10522697.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    2. Orai3 Calcium Channel Contributes to Oral/Oropharyngeal Cancer Stemness through the Elevation of ID1 Expression. Cells. 2023 09 07; 12(18). Nguyen A, Sung Y, Lee SH, Martin CE, Srikanth S, Chen W, Kang MK, Kim RH, Park NH, Gwack Y, Kim Y, Shin KH. PMID: 37759448; PMCID: PMC10527097.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Comparative Analysis of Molecular Pathogenic Mechanisms and Antiviral Development Targeting Old and New World Hantaviruses. bioRxiv. 2023 Aug 05. Jeyachandran AV, Irudayam JI, Dubey S, Chakravarty N, Konda B, Shah A, Su B, Wang C, Cui Q, Williams KJ, Srikanth S, Shi Y, Deb A, Damoiseaux R, Stripp BR, Ramaiah A, Arumugaswami V. PMID: 37577539; PMCID: PMC10418258.
      View in: PubMed   Mentions:
    4. Ca2+ Signaling Augmented by ORAI1 Trafficking Regulates the Pathogenic State of Effector T Cells. J Immunol. 2022 03 15; 208(6):1329-1340. Wu B, Woo JS, Sun Z, Srikanth S, Gwack Y. PMID: 35217583; PMCID: PMC8916982.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    5. Biallelic mutations in calcium release activated channel regulator 2A (CRACR2A) cause a primary immunodeficiency disorder. Elife. 2021 12 15; 10. Wu B, Rice L, Shrimpton J, Lawless D, Walker K, Carter C, McKeown L, Anwar R, Doody GM, Srikanth S, Gwack Y, Savic S. PMID: 34908525; PMCID: PMC8673834.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    6. ORAI1 Limits SARS-CoV-2 Infection by Regulating Tonic Type I IFN Signaling. J Immunol. 2022 01 01; 208(1):74-84. Wu B, Ramaiah A, Garcia G, Hasiakos S, Arumugaswami V, Srikanth S. PMID: 34819389; PMCID: PMC8702473.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    7. NKD2 mediates stimulation-dependent ORAI1 trafficking to augment Ca2+ entry in T cells. Cell Rep. 2021 08 24; 36(8):109603. Wu B, Woo JS, Vila P, Jew M, Leung J, Sun Z, Srikanth S, Gwack Y. PMID: 34433025; PMCID: PMC8435239.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    8. ORAI1 establishes resistance to SARS-CoV-2 infection by regulating tonic type I interferon signaling. bioRxiv. 2021 May 04. Wu B, Ramaiah A, Garcia G, Gwack Y, Arumugaswami V, Srikanth S. PMID: 33972946; PMCID: PMC8109209.
      View in: PubMed   Mentions:
    9. Blue light opens the ORAI1 LOC(K). Cell Calcium. 2021 05; 95:102371. Srikanth S, Gwack Y. PMID: 33626404.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    10. The short isoform of extended synaptotagmin-2 controls Ca2+ dynamics in T cells via interaction with STIM1. Sci Rep. 2020 09 02; 10(1):14433. Woo JS, Sun Z, Srikanth S, Gwack Y. PMID: 32879390; PMCID: PMC7468131.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    11. Correction: CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses. J Immunol. 2019 Jul 01; 203(1):293. Woo JS, Srikanth S, Kim KD, Elsaesser H, Lu J, Pellegrini M, Brooks DG, Sun Z, Gwack Y. PMID: 31127031.
      View in: PubMed   Mentions:    Fields:    
    12. A Report of Novel STIM1 Deficiency and 6-Year Follow-Up of Two Previous Cases Associated with Mild Immunological Phenotype. J Clin Immunol. 2019 04; 39(3):249-256. Rice L, Stockdale C, Berry I, O'Riordan S, Pysden K, Anwar R, Rushambuza R, Blyth M, Srikanth S, Gwack Y, El-Sherbiny YM, Carter C, Savic S. PMID: 30949876.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    13. The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum. Nat Immunol. 2019 02; 20(2):152-162. Srikanth S, Woo JS, Wu B, El-Sherbiny YM, Leung J, Chupradit K, Rice L, Seo GJ, Calmettes G, Ramakrishna C, Cantin E, An DS, Sun R, Wu TT, Jung JU, Savic S, Gwack Y. PMID: 30643259; PMCID: PMC6340781.
      View in: PubMed   Mentions: 143     Fields:    Translation:HumansAnimalsCells
    14. CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses. J Immunol. 2018 08 15; 201(4):1174-1185. Woo JS, Srikanth S, Kim KD, Elsaesser H, Lu J, Pellegrini M, Brooks DG, Sun Z, Gwack Y. PMID: 29987160; PMCID: PMC6081249.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    15. Deletion of Orai1 leads to bone loss aggravated with aging and impairs function of osteoblast lineage cells. Bone Rep. 2018 Jun; 8:147-155. Choi H, Srikanth S, Atti E, Pirih FQ, Nervina JM, Gwack Y, Tetradis S. PMID: 29955633; PMCID: PMC6020256.
      View in: PubMed   Mentions: 10  
    16. Laminar flow downregulates Notch activity to promote lymphatic sprouting. J Clin Invest. 2017 Apr 03; 127(4):1225-1240. Choi D, Park E, Jung E, Seong YJ, Yoo J, Lee E, Hong M, Lee S, Ishida H, Burford J, Peti-Peterdi J, Adams RH, Srikanth S, Gwack Y, Chen CS, Vogel HJ, Koh CJ, Wong AK, Hong YK. PMID: 28263185; PMCID: PMC5373895.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    17. ORAI1 Activates Proliferation of Lymphatic Endothelial Cells in Response to Laminar Flow Through Krüppel-Like Factors 2 and 4. Circ Res. 2017 Apr 28; 120(9):1426-1439. Choi D, Park E, Jung E, Seong YJ, Hong M, Lee S, Burford J, Gyarmati G, Peti-Peterdi J, Srikanth S, Gwack Y, Koh CJ, Boriushkin E, Hamik A, Wong AK, Hong YK. PMID: 28167653; PMCID: PMC6300148.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    18. Immunological Disorders: Regulation of Ca2+ Signaling in T Lymphocytes. Adv Exp Med Biol. 2017; 993:397-424. Srikanth S, Woo JS, Sun Z, Gwack Y. PMID: 28900926; PMCID: PMC8957800.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    19. Orai1 promotes tumor progression by enhancing cancer stemness via NFAT signaling in oral/oropharyngeal squamous cell carcinoma. Oncotarget. 2016 Jul 12; 7(28):43239-43255. Lee SH, Rigas NK, Lee CR, Bang A, Srikanth S, Gwack Y, Kang MK, Kim RH, Park NH, Shin KH. PMID: 27259269; PMCID: PMC5190020.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    20. A large Rab GTPase family in a small GTPase world. Small GTPases. 2017 01 02; 8(1):43-48. Srikanth S, Woo JS, Gwack Y. PMID: 27221160; PMCID: PMC5331893.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    21. Orai1 mediates osteogenic differentiation via BMP signaling pathway in bone marrow mesenchymal stem cells. Biochem Biophys Res Commun. 2016 05 13; 473(4):1309-1314. Lee SH, Park Y, Song M, Srikanth S, Kim S, Kang MK, Gwack Y, Park NH, Kim RH, Shin KH. PMID: 27086849; PMCID: PMC4853278.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    22. A large Rab GTPase encoded by CRACR2A is a component of subsynaptic vesicles that transmit T cell activation signals. Sci Signal. 2016 Mar 22; 9(420):ra31. Srikanth S, Kim KD, Gao Y, Woo JS, Ghosh S, Calmettes G, Paz A, Abramson J, Jiang M, Gwack Y. PMID: 27016526; PMCID: PMC5013727.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    23. Junctophilin-4, a component of the endoplasmic reticulum-plasma membrane junctions, regulates Ca2+ dynamics in T cells. Proc Natl Acad Sci U S A. 2016 Mar 08; 113(10):2762-7. Woo JS, Srikanth S, Nishi M, Ping P, Takeshima H, Gwack Y. PMID: 26929330; PMCID: PMC4790987.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    24. Dental enamel cells express functional SOCE channels. Sci Rep. 2015 Oct 30; 5:15803. Nurbaeva MK, Eckstein M, Concepcion AR, Smith CE, Srikanth S, Paine ML, Gwack Y, Hubbard MJ, Feske S, Lacruz RS. PMID: 26515404; PMCID: PMC4626795.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    25. The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4⁺ T cells. Nat Immunol. 2014 Nov; 15(11):1055-1063. Bertin S, Aoki-Nonaka Y, de Jong PR, Nohara LL, Xu H, Stanwood SR, Srikanth S, Lee J, To K, Abramson L, Yu T, Han T, Touma R, Li X, González-Navajas JM, Herdman S, Corr M, Fu G, Dong H, Gwack Y, Franco A, Jefferies WA, Raz E. PMID: 25282159; PMCID: PMC4843825.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
    26. Interplay between the oxidoreductase PDIA6 and microRNA-322 controls the response to disrupted endoplasmic reticulum calcium homeostasis. Sci Signal. 2014 Jun 10; 7(329):ra54. Groenendyk J, Peng Z, Dudek E, Fan X, Mizianty MJ, Dufey E, Urra H, Sepulveda D, Rojas-Rivera D, Lim Y, Kim DH, Baretta K, Srikanth S, Gwack Y, Ahnn J, Kaufman RJ, Lee SK, Hetz C, Kurgan L, Michalak M. PMID: 24917591; PMCID: PMC4984425.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    27. Methods to measure cytoplasmic and mitochondrial Ca(2+) concentration using Ca(2+)-sensitive dyes. Methods Enzymol. 2014; 543:1-20. Srikanth S, Kim KD, Gwack Y. PMID: 24924125.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    28. Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation. J Immunol. 2014 Jan 01; 192(1):110-22. Kim KD, Srikanth S, Tan YV, Yee MK, Jew M, Damoiseaux R, Jung ME, Shimizu S, An DS, Ribalet B, Waschek JA, Gwack Y. PMID: 24307733; PMCID: PMC3874217.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    29. Orai1-NFAT signalling pathway triggered by T cell receptor stimulation. Mol Cells. 2013 Mar; 35(3):182-94. Srikanth S, Gwack Y. PMID: 23483280; PMCID: PMC3887911.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    30. Regulation of CRAC channels by protein interactions and post-translational modification. Channels (Austin). 2013 Sep-Oct; 7(5):354-63. Srikanth S, Ribalet B, Gwack Y. PMID: 23454861; PMCID: PMC3893732.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    31. Measurement of intracellular Ca2+ concentration in single cells using ratiometric calcium dyes. Methods Mol Biol. 2013; 963:3-14. Srikanth S, Gwack Y. PMID: 23296601.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    32. Molecular regulation of the pore component of CRAC channels, Orai1. Curr Top Membr. 2013; 71:181-207. Srikanth S, Gwack Y. PMID: 23890116.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    33. Orai1, STIM1, and their associating partners. J Physiol. 2012 Sep 01; 590(17):4169-77. Srikanth S, Gwack Y. PMID: 22586216; PMCID: PMC3473276.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    34. Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1). Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8682-7. Srikanth S, Jew M, Kim KD, Yee MK, Abramson J, Gwack Y. PMID: 22586105; PMCID: PMC3365170.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    35. ORAI1 deficiency impairs activated T cell death and enhances T cell survival. J Immunol. 2011 Oct 01; 187(7):3620-30. Kim KD, Srikanth S, Yee MK, Mock DC, Lawson GW, Gwack Y. PMID: 21873530; PMCID: PMC3178683.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    36. The third transmembrane segment of orai1 protein modulates Ca2+ release-activated Ca2+ (CRAC) channel gating and permeation properties. J Biol Chem. 2011 Oct 07; 286(40):35318-28. Srikanth S, Yee MK, Gwack Y, Ribalet B. PMID: 21865174; PMCID: PMC3186358.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    37. Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation. J Immunol. 2011 Jan 15; 186(2):940-50. Newton RH, Leverrier S, Srikanth S, Gwack Y, Cahalan MD, Walsh CM. PMID: 21148796; PMCID: PMC3133617.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    38. A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells. Nat Cell Biol. 2010 May; 12(5):436-46. Srikanth S, Jung HJ, Kim KD, Souda P, Whitelegge J, Gwack Y. PMID: 20418871; PMCID: PMC2875865.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansCells
    39. The intracellular loop of Orai1 plays a central role in fast inactivation of Ca2+ release-activated Ca2+ channels. J Biol Chem. 2010 Feb 12; 285(7):5066-75. Srikanth S, Jung HJ, Ribalet B, Gwack Y. PMID: 20007711; PMCID: PMC2836109.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    40. Hair loss and defective T- and B-cell function in mice lacking ORAI1. Mol Cell Biol. 2008 Sep; 28(17):5209-22. Gwack Y, Srikanth S, Oh-Hora M, Hogan PG, Lamperti ED, Yamashita M, Gelinas C, Neems DS, Sasaki Y, Feske S, Prakriya M, Rajewsky K, Rao A. PMID: 18591248; PMCID: PMC2519726.
      View in: PubMed   Mentions: 168     Fields:    Translation:AnimalsCells
    41. Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps. Mol Biol Cell. 2008 Jul; 19(7):2802-17. Barr VA, Bernot KM, Srikanth S, Gwack Y, Balagopalan L, Regan CK, Helman DJ, Sommers CL, Oh-Hora M, Rao A, Samelson LE. PMID: 18448669; PMCID: PMC2441672.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
    42. Signalling to transcription: store-operated Ca2+ entry and NFAT activation in lymphocytes. Cell Calcium. 2007 Aug; 42(2):145-56. Gwack Y, Feske S, Srikanth S, Hogan PG, Rao A. PMID: 17572487.
      View in: PubMed   Mentions: 156     Fields:    Translation:HumansAnimalsCells
    43. Biochemical and functional characterization of Orai proteins. J Biol Chem. 2007 Jun 01; 282(22):16232-43. Gwack Y, Srikanth S, Feske S, Cruz-Guilloty F, Oh-hora M, Neems DS, Hogan PG, Rao A. PMID: 17293345.
      View in: PubMed   Mentions: 202     Fields:    Translation:HumansAnimalsCells
    44. Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components. J Biol Chem. 2007 Mar 23; 282(12):9105-16. Ong HL, Cheng KT, Liu X, Bandyopadhyay BC, Paria BC, Soboloff J, Pani B, Gwack Y, Srikanth S, Singh BB, Gill DL, Gill D, Ambudkar IS. PMID: 17224452; PMCID: PMC3309402.
      View in: PubMed   Mentions: 171     Fields:    Translation:HumansAnimalsCells
    45. Orai1 is an essential pore subunit of the CRAC channel. Nature. 2006 Sep 14; 443(7108):230-3. Prakriya M, Feske S, Gwack Y, Srikanth S, Rao A, Hogan PG. PMID: 16921383.
      View in: PubMed   Mentions: 626     Fields:    Translation:HumansCells
    46. Compensation of inositol 1,4,5-trisphosphate receptor function by altering sarco-endoplasmic reticulum calcium ATPase activity in the Drosophila flight circuit. J Neurosci. 2006 Aug 09; 26(32):8278-88. Banerjee S, Joshi R, Venkiteswaran G, Agrawal N, Srikanth S, Alam F, Hasan G. PMID: 16899722; PMCID: PMC6673814.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    47. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature. 2006 May 11; 441(7090):179-85. Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A. PMID: 16582901.
      View in: PubMed   Mentions: 1060     Fields:    Translation:HumansAnimalsCells
    48. A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT. Nature. 2006 Jun 01; 441(7093):646-50. Gwack Y, Sharma S, Nardone J, Tanasa B, Iuga A, Srikanth S, Okamura H, Bolton D, Feske S, Hogan PG, Rao A. PMID: 16511445.
      View in: PubMed   Mentions: 171     Fields:    Translation:AnimalsCells
    49. Ectopic expression of a Drosophila InsP(3)R channel mutant has dominant-negative effects in vivo. Cell Calcium. 2006 Feb; 39(2):187-96. Srikanth S, Banerjee S, Hasan G. PMID: 16325255.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    50. Functional properties of a pore mutant in the Drosophila melanogaster inositol 1,4,5-trisphosphate receptor. FEBS Lett. 2004 Sep 24; 575(1-3):95-8. Srikanth S, Wang Z, Hasan G, Bezprozvanny I. PMID: 15388340.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    51. Functional properties of the Drosophila melanogaster inositol 1,4,5-trisphosphate receptor mutants. Biophys J. 2004 Jun; 86(6):3634-46. Srikanth S, Wang Z, Tu H, Nair S, Mathew MK, Hasan G, Bezprozvanny I. PMID: 15189860; PMCID: PMC1304265.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
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